Recombinant host cells comprising phosphoketolases

ABSTRACT

The present invention is related to recombinant host cells comprising: (i) at least one deletion, mutation, and/or substitution in an endogenous gene encoding a polypeptide that converts pyruvate to acetaldehyde, acetyl-phosphate or acetyl-CoA; and (ii) a heterologous polynucleotide encoding a polypeptide having phosphoketolase activity. The present invention is also related to recombinant host cells further comprising (iii) a heterologous polynucleotide encoding a polypeptide having phosphotransacetylase activity.

CROSS-REFERENCE TO RELATED APPLICATIONS

This application is related to and claims the benefit of priority ofU.S. Provisional Patent Application No. 61/356,379, filed on Jun. 18,2010, the entirety of which is herein incorporated by reference.

FIELD OF THE INVENTION

The invention relates generally to the field of industrial microbiology.The invention relates to recombinant host cells comprising (i) amodification in an endogenous gene encoding a polypeptide that convertspyruvate to acetyl-CoA, acetaldehyde or acetyl-phosphate and (ii) aheterologous polynucleotide encoding a polypeptide havingphosphoketolase activity. The invention also relates to recombinant hostcells comprising (i) a modification in an endogenous gene encoding apolypeptide having pyruvate decarboxylase (PDC) activity, or amodification in an endogenous polypeptide having PDC activity, and (ii)a heterologous polynucleotide encoding a polypeptide havingphosphoketolase activity. The invention also relates to recombinant hostcells further comprising (iii) a heterologous polynucleotide encoding apolypeptide having phosphotransacetylase activity. Additionally, theinvention relates to methods of making and using such recombinant hostcells including, for example, methods of increasing cell growth, methodsof reducing or eliminating the requirement of an exogenous carbonsubstrate for cell growth, methods of increasing glucose consumption andmethods of increasing the production of a product of apyruvate-utilizing pathway.

BACKGROUND OF THE INVENTION

Global demand for liquid transportation fuel is projected to strain theability to meet certain environmentally driven goals, for example, theconservation of oil reserves and limitation of green house gasemissions. Such demand has driven the development of technology whichallows utilization of renewable resources to mitigate the depletion ofoil reserves and to minimize green house gas emissions.

Butanol is an important industrial chemical, useful as a fuel additive,as a feedstock chemical in the plastics industry, and as a food gradeextractant in the food and flavor industry. Each year 10 to 12 billionpounds of butanol are produced by petrochemical means and the need forthis commodity chemical will likely increase in the future.

Methods for the chemical synthesis of isobutanol are known, such as oxosynthesis, catalytic hydrogenation of carbon monoxide (Ullmann'sEncyclopedia of Industrial Chemistry, 6th edition, 2003, Wiley-VCHVerlag GmbH and Co., Weinheim, Germany, Vol. 5, pp. 716-719) and Guerbetcondensation of methanol with n-propanol (Carlini et al., J. Molec.Catal. A: Chem. 220:215-220, 2004). These processes use startingmaterials derived from petrochemicals, are generally expensive, and arenot environmentally friendly. The production of isobutanol fromplant-derived raw materials would minimize green house gas emissions andwould represent an advance in the art.

2-Butanone, also referred to as methyl ethyl ketone (MEK), is a widelyused solvent and is the most important commercially produced ketone,after acetone. It is used as a solvent for paints, resins, andadhesives, as well as a selective extractant, activator of oxidativereactions, and it can be chemically converted to 2-butanol by reactingwith hydrogen in the presence of a catalyst (Nystrom, R. F. and Brown,W. G. (J. Am. Chem. Soc. (1947) 69:1198). 2,3-butanediol can be used inthe chemical synthesis of butene and butadiene, important industrialchemicals currently obtained from cracked petroleum, and esters of2,3-butanediol may be used as plasticizers (Voloch et al., “FermentationDerived 2,3-Butanediol,” in Comprehensive Biotechnology, Pergamon PressLtd., England Vol. 2, Section 3:933-947 (1986)).

Microorganisms can be engineered for the expression of biosyntheticpathways that initiate with cellular pyruvate to produce, for example,2,3-butanediol, 2-butanone, 2-butanol and isobutanol. U.S. Pat. No.7,851,188 discloses the engineering of recombinant microorganisms forproduction of isobutanol. U.S. Patent Application Publication Nos. US20070259410 A1 and US 20070292927 A1 disclose the engineering ofrecombinant microorganisms for production of 2-butanone or 2-butanol.Multiple pathways are disclosed for biosynthesis of isobutanol and2-butanol, all of which initiate with cellular pyruvate. Butanediol isan intermediate in the 2-butanol pathway disclosed in U.S. PatentApplication Publication No. US 20070292927 A1.

The disruption of the enzyme pyruvate decarboxylase (PDC) in recombinanthost cells engineered to express a pyruvate-utilizing biosyntheticpathway has been used to increase the availability of pyruvate forproduct formation via the biosynthetic pathway. For example, U.S.Application Publication No. US 20070031950 A1 discloses a yeast strainwith a disruption of one or more pyruvate decarboxylase genes (a PDCknock-out or PDC-KO) and expression of a D-lactate dehydrogenase gene,which is used for production of D-lactic acid. U.S. ApplicationPublication No. US 20050059136 A1 discloses glucose tolerant two-carbonsource-independent (GCSI) yeast strains with no PDC activity, which mayhave an exogenous lactate dehydrogenase gene. Nevoigt and Stahl (Yeast12:1331-1337 (1996)) describe the impact of reduced PDC and increasedNAD-dependent glycerol-3-phosphate dehydrogenase in Saccharomycescerevisiae on glycerol yield. U.S. Application Publication No.20090305363 A1 discloses increased conversion of pyruvate toacetolactate by engineering yeast for expression of a cytosol-localizedacetolactate synthase and substantial elimination of PDC activity.

While PDC-KO recombinant host cells can be used to produce the productsof pyruvate-utilizing biosynthetic pathways, PDC-KO recombinant hostcells require exogenous carbon substrate supplementation (e.g., ethanolor acetate) for their growth (Flikweert et al. 1999. FEMS Microbiol.Lett. 174(1):73-79 “Growth requirements ofpyruvate-decarboxylase-negative Saccharomyces cerevisiae”). A similarauxotrophy is observed in Escherichia coli strains carrying a mutationof one or more genes encoding pyruvate dehydrogenase (Langley and Guest,1977, J. Gen. Microbiol. 99:263-276).

In commercial applications, addition of exogenous carbon substrate inaddition to the substrate converted to a desired product can lead toincreased costs. There remains a need in the art for recombinant hostcells with reduced or eliminated need for exogenous carbon substratesupplementation.

BRIEF SUMMARY OF THE INVENTION

One aspect of the invention relates to a recombinant host cellcomprising (i) at least one deletion, mutation, and/or substitution inan endogenous gene encoding a polypeptide that converts pyruvate toacetaldehyde, acetyl-phosphate, or acetyl-CoA; and (ii) a heterologouspolynucleotide encoding a polypeptide having phosphoketolase activity.Another aspect of the invention relates to such a recombinant host cellfurther comprising (iii) a heterologous polynucleotide encoding apolypeptide having phosphotransacetylase activity. In embodiments, thepolypeptide that converts pyruvate to acetaldehyde, acetyl-phosphate, oracetyl-CoA is pyruvate decarboxylase, pyruvate-formate lyase, pyruvatedehydrogenase, pyruvate oxidase, or pyruvate:ferredoxin oxidoreductase.

One aspect of the invention relates to a recombinant host cellcomprising (i) a modification in an endogenous gene encoding apolypeptide having pyruvate decarboxylase activity or in an endogenouspolypeptide having pyruvate decarboxylase activity; and (ii) aheterologous polynucleotide encoding a polypeptide havingphosphoketolase activity. Another aspect of the invention relates tosuch a recombinant host cell further comprising (iii) a heterologouspolynucleotide encoding a polypeptide having phosphotransacetylaseactivity.

One aspect of the invention relates to a recombinant host cellcomprising (i) at least one deletion, mutation, and/or substitution inan endogenous gene encoding a polypeptide having pyruvate decarboxylaseactivity; and (ii) a heterologous polynucleotide encoding a polypeptidehaving phosphoketolase activity. Another aspect of the invention relatesto a recombinant host cell further comprising: (iii) a heterologouspolynucleotide encoding a polypeptide having phosphotransacetylaseactivity. Another aspect of invention relates to a reduced or eliminatedrequirement of such cells for an exogenous two-carbon substrate for itsgrowth in culture compared to a recombinant eukaryotic host cellcomprising (i) and not (ii) or (iii). Another aspect of the inventionrelates to the growth of such host cells in culture media that is notsupplemented with an exogenous two-carbon substrate, for example, at agrowth rate substantially equivalent to, or greater than, the growthrate of a host cell comprising (i) and not (ii) or (iii) in culturemedia supplemented with an exogenous two-carbon substrate.

In one aspect of the invention, the recombinant host cell is a member ofthe genera Clostridium, Zymomonas, Escherichia, Salmonella, Serratia,Erwinia, Klebsiella, Shigella, Rhodococcus, Pseudomonas, Bacillus,Lactobacillus, Enterococcus, Alcaligenes, Klebsiella, Paenibacillus,Arthrobacter, Corynebacterium, Brevibacterium, Schizosaccharomyces,Kluyveromyces, Yarrowia, Pichia, Candida, Hansenula, or Saccharomyces.In another aspect of the invention, the recombinant host cell is S.cerevisiae.

In another aspect of the invention, the recombinant host cell expressesa pyruvate-utilizing biosynthetic pathway including, for example, abiosynthetic pathway for a product such as 2,3-butanediol, isobutanol,2-butanol, 2-butanone, valine, leucine, alanine, lactic acid, malicacid, fumaric acid, succinic acid, or isoamyl alcohol. Another aspect ofthe invention relates to expression of an isobutanol biosyntheticpathway in the recombinant host cell comprising at least one DNAmolecule encoding a polypeptide that catalyzes a substrate to productconversion selected from the group consisting of (i) pyruvate toacetolactate; (ii) acetolactate to 2,3-dihydroxyisovalerate; (iii)2,3-dihydroxyisovalerate to 2-ketoisovalerate; (iv) 2-ketoisovalerate toisobutyraldehyde; and (v) isobutyraldehyde to isobutanol. Another aspectof the invention relates to expression of a 2-butanone biosyntheticpathway in the recombinant host cell comprising at least one DNAmolecule encoding a polypeptide that catalyzes a substrate to productconversion selected from the group consisting of (i) pyruvate toacetolactate; (ii) acetolactate to acetoin; (iii) acetoin to2,3-butanediol; and (iv) 2,3-butanediol to 2-butanone.

Another aspect of the invention relates to expression of a 2-butanolbiosynthetic pathway in the recombinant host cell comprising at leastone DNA molecule encoding a polypeptide that catalyzes a substrate toproduct conversion selected from the group consisting of (i) pyruvate toacetolactate; (ii) acetolactate to acetoin; (iii) acetoin to2,3-butanediol; (iv) 2,3-butanediol to 2-butanone; and (v) 2-butanone to2-butanol.

One aspect of the invention relates to methods for the production of aproduct selected from the group consisting of 2,3-butanediol,isobutanol, 2-butanol, 2-butanone, valine, leucine, alanine, lacticacid, malic acid, fumaric acid, succinic acid and isoamyl alcoholcomprising growing the recombinant host cells described herein underconditions wherein the product is produced and optionally recovering theproduct. Another aspect of the invention relates to methods of producinga recombinant host cell comprising transforming a host cell comprisingat least one deletion, mutation, and/or substitution in an endogenousgene encoding a polypeptide having pyruvate decarboxylase activity with(i) a heterologous polynucleotide encoding a polypeptide havingphosphoketolase activity; and optionally (ii) a heterologouspolynucleotide encoding a polypeptide having phosphotransacetylaseactivity.

Another aspect of the invention relates to methods of improving thegrowth of a recombinant host cell comprising at least one deletion,mutation or substitution in an endogenous gene encoding a polypeptidehaving pyruvate decarboxylase activity, comprising (i) transforming therecombinant host cell with a heterologous polynucleotide encoding apolypeptide having phosphoketolase activity; and optionally (ii)transforming the recombinant host cell with a heterologouspolynucleotide encoding a polypeptide having phosphotransacetylaseactivity. In embodiments, the methods further comprise growing therecombinant host cell in media containing limited carbon substrate.

Another aspect of the invention relates to methods of reducing therequirement for an exogenous two-carbon substrate for the growth of arecombinant host cell comprising at least one deletion, mutation orsubstitution in an endogenous gene encoding a polypeptide havingpyruvate decarboxylase activity, comprising (i) transforming the hostcell with a heterologous polynucleotide encoding a polypeptide havingphosphoketolase activity; and optionally (ii) transforming the host cellwith a heterologous polynucleotide encoding a polypeptide havingphosphotransacetylase activity.

Another aspect of the invention relates to methods of eliminating therequirement for an exogenous two-carbon substrate for the growth of arecombinant host cell comprising at least one deletion, mutation orsubstitution in an endogenous gene encoding a polypeptide havingpyruvate decarboxylase activity, comprising (i) transforming the hostcell with a heterologous polynucleotide encoding a polypeptide havingphosphoketolase activity; and optionally (ii) transforming the host cellwith a heterologous polynucleotide encoding a polypeptide havingphosphotransacetylase activity.

Still another aspect of the invention relates to methods for increasingthe activity of the phosphoketolase pathway in a recombinant host cellcomprising (i) providing a recombinant host cell of the invention; and(ii) growing the recombinant host cell under conditions whereby theactivity of the phosphoketolase pathway in the recombinant host cell isincreased.

In another aspect, the recombinant host cells comprise a phosphoketolasethat matches the Profile HMM given in Table 6 with an E value of lessthan 7.5E-242. In another aspect, the phosphoketolase has at least about40% identity to at least one of SEQ ID NO: 355, 379, 381, 388, 481, 486,468, or 504. In another aspect, the phosphoketolase has at least about90% identity to at least one of SEQ ID NO: 355, 379, 381, 388, 481, 486,468, or 504. In another aspect, the phosphoketolase matches the ProfileHMMs given in Tables 6, 7, 8, and 9 with E values of less than 7.5E-242,1.1E-124, 2.1E-49, 7.8E-37, respectively. In another aspect, therecombinant host cells further comprise a phosphotransacetylase whichmatches the Profile HMM given in Table 14 with an E value of less than5E-34. In another aspect, the phosphotransacetylase has at least about40% identity to SEQ ID NO: 1475, 1472, 1453, 1422, 1277, 1275, 1206,1200, 1159, or 1129. In another aspect, the phosphotransacetylase has atleast about 90% identity to SEQ ID NO: 1475, 1472, 1453, 1422, 1277,1275, 1206, 1200, 1159, or 1129

BRIEF DESCRIPTION OF THE DRAWINGS/FIGURES AND INCORPORATION OF SEQUENCELISTING AND TABLES

The various embodiments of the invention can be more fully understoodfrom the detailed description, the figures, and the accompanyingsequence descriptions, which form a part of this application.

FIG. 1 depicts a schematic representation of the phosphoketolasepathway, including the phosphoketolase and phosphotransacetylaseenzymes.

FIG. 2 depicts the growth of PDC-KO yeast strains expressingphosphoketolase and phosphotransacetylase without exogenous carbonsubstrate supplementation.

FIG. 3 depicts the growth of PDC-KO yeast strains expressingphosphoketolase and/or phosphotransacetylase in without exogenous carbonsubstrate supplementation.

FIG. 4 depicts a phylogenetic tree of phosphate acetyltransferase (PTA)and phosphate butyryltransferase (PTB) sequences. Multiple sequencealignment was performed with Clustal X using default parameters.Phylogenetic tree was deduced using neighbor joining method and drawnwith Mega 4 software. Marked sequences are as follows: (#, Species, GI#)1, S. enterica, 56412650; 2, E. coli K12, 88192043; 3, V. parvula,227371784; 4, C. kluyveri, 153954015; 5, C. Acetobutylicum, 15895019; 6,C. thermocellum, 196254011; 7, M. thermophile, 88192043; 8, S. pyogenes,48425286; 9, B. subtilis, 58176784; 10, L. fermentum, 227514417; 11, L.plantarum, 28377658; 12, L. sanfranciscensis, 11862872;

FIG. 5 is a plasmid map of pRS426::GPD-xpk1+ADH-eutD map which isdescribed herein.

FIG. 6 depicts the Δpdc1::ilvD(Sm) locus of BP913 after integration of aphosphoketolase pathway vector (described herein).

FIG. 7A shows the growth of an isobutanol-producing strain in theabsence (no ETOH) and presence (+ETOH) of EtOH and the absence andpresence of the phosphoketolase pathway (xpk). ISO1, ISO2 and ISO3 referto replicates.

FIG. 7B shows the growth of a second subculture of strains from FIG. 7A.

Tables 6, 7, 8, 9, and 14 are tables of the Profile HMMs describedherein. Table 6, 7, 8, 9, and 14 are submitted herewith electronicallyand are incorporated herein by reference.

The invention can be more fully understood from the following detaileddescription and the accompanying sequence descriptions which form a partof this application.

The sequence listing provided herewith is herein incorporated byreference and conforms with 37 C.F.R. 1.821-1.825 (“Requirements forPatent Applications Containing Nucleotide Sequences and/or Amino AcidSequence Disclosures—the Sequence Rules”) and is consistent with WorldIntellectual Property Organization (WIPO) Standard ST.25 (2009) and thesequence listing requirements of the EPO and PCT (Rules 5.2 and49.5(a-bis), and Section 208 and Annex C of the AdministrativeInstructions). The symbols and format used for nucleotide and amino acidsequence data comply with the rules set forth in 37 C.F.R. §1.822. Thecontent of the electronically submitted sequence listing Name:20110615_CL4871USNA SeqList.txt; Size: 6.67 MB; and Date ofCreation/Modification: Jun. 9, 2011/Jun. 15, 2011 is incorporated hereinby reference in its entirety.

SEQ ID NOs: 1-20 are sequences of PDC target gene coding regions andproteins.

SEQ ID NOs: 21-638 are phosphoketolase target gene coding regions andproteins.

SEQ ID NOs: 762-1885 are phosphotransacetylase target gene codingregions and proteins.

SEQ ID NOs: 1893-1897 are hybrid promoter sequences.

SEQ ID NOs: 639-642, 644-654, 656-660, 662-701-714, 725-726, 729-740,742-748, and 750-761 are primers.

SEQ ID NO: 643 is the vector pRS426::GPD-xpk1+ADH1-eutD.

SEQ ID NO: 655 is the TEF1p-kan-TEF1t gene.

SEQ ID NO: 661 is vector pLA54.

SEQ ID NO: 715 is vector pRS423::pGAL1-cre.

SEQ ID NO: 716 is the vector pLH468-sadB.

SEQ ID NOs: 717 and 718 are the amino acid and nucleic acid sequencesfor sadB from Achromobacter xylosoxidans.

SEQ ID NO: 719 is the kivD coding region from L. lactis.

SEQ ID NO: 720 is the plasmid pRS425::GPM-sadB.

SEQ ID NO: 721 is the GPM promoter.

SEQ ID NO: 722 is the ADH1 terminator.

SEQ ID NO: 723 is the GPM-sadB-ADHt segment.

SEQ ID NO: 724 is the pUC19-URA3 plasmid.

SEQ ID NO: 741 is the ilvD-FBA1t segment.

SEQ ID NO: 749 is URA3r2 template DNA.

SEQ ID NO: 1886 is the ilvD coding region from S. mutans.

SEQ ID NO: 1888 is vector pLH468.

SEQ ID NO: 1898 is pUC19-URA3::pdc1::GPD-xpk1+ADH1-eutD.

SEQ ID NOs: 1899-1906 are the sequences of modified S. cerevisiae loci.

SEQ ID NO: 1907 is the sequence of pLH702.

SEQ ID NO: 1908 is the sequence of pYZ067DkivDDhADH.

SEQ ID NO: 1909 is the amino acid sequence of ALD6.

SEQ ID NO: 1910 is the amino acid sequence of K9D3.

SEQ ID NO: 1911 is the amino acid sequence of K9G9.

SEQ ID NO: 1912 is the amino acid sequence of YMR226c.

SEQ ID NOs: 1913 and 1914 are the nucleic acid and amino acid sequencesof AFT1.

SEQ ID NOs: 1915 and 1916 are the nucleic acid and amino acid sequencesof AFT2.

SEQ ID NOs: 1917 and 1918 are the nucleic acid and amino acid sequencesof FRA2.

SEQ ID NOs: 1919 and 1920 are the nucleic acid and amino acid sequencesof GRX3.

SEQ ID NOs: 1921 and 1922 are the nucleic acid and amino acid sequencesof CCC1.

SEQ ID NO: 1923 is the amino acid sequence of an alcohol dehydrogenasefrom Beijerinkia indica.

DETAILED DESCRIPTION OF THE INVENTION

Applicants have solved the stated problem by reducing or eliminating theneed for providing two substrates, one of which is converted to adesired product, the other fully or partly into acetyl-CoA byrecombinant host cells requiring such supplementation for growthcomprising the expression of enzymes of the phosphoketolase pathway insuch cells. One such enzyme, phosphoketolase (Enzyme Commission NumberEC 4.1.2.9), catalyzes the conversion of xylulose 5-phosphate intoglyceraldehyde 3-phosphate and acetyl-phosphate (Heath et al., J. Biol.Chem. 231: 1009-29; 1958). Another such enzyme is phosphotransacetylase(Enzyme Commission Number EC 2.3.1.8) which converts acetyl-phosphateinto acetyl-CoA.

Applicants have provided PDC-KO recombinant host cells comprising aheterologous polynucleotide encoding a polypeptide havingphosphoketolase activity, and optionally a heterologous polynucleotideencoding a polypeptide having phosphotransacetylase activity. Such cellsexhibit a reduced or eliminated requirement for exogenous two-carbonsubstrate supplementation for their growth compared to PDC-KO cells.Applicants have also provided methods of making and using suchrecombinant host cells including, for example, methods of increasingcell growth, methods of reducing or eliminating the requirement of anexogenous two-carbon substrate for cell growth, methods of increasingglucose consumption and methods of increasing the production of aproduct of a pyruvate-utilizing pathway.

Unless defined otherwise, all technical and scientific terms used hereinhave the same meaning as commonly understood by one of ordinary skill inthe art to which this invention belongs. In case of conflict, thepresent application including the definitions will control. Unlessotherwise required by context, singular terms shall include pluralitiesand plural terms shall include the singular. All publications, patentsand other references mentioned herein are incorporated by reference intheir entireties for all purposes as if each individual publication orpatent application were specifically and individually indicated to beincorporated by reference, unless only specific sections of patents orpatent publications are indicated to be incorporated by reference.

Although methods and materials similar or equivalent to those describedherein can be used in practice or testing of the present invention,suitable methods and materials are described below. The materials,methods and examples are illustrative only and are not intended to belimiting. Other features and advantages of the invention will beapparent from the detailed description and from the claims.

In order to further define this invention, the following terms,abbreviations and definitions are provided.

As used herein, the terms “comprises,” “comprising,” “includes,”“including,” “has,” “having,” “contains,” or “containing,” or any othervariation thereof, are intended to be non-exclusive or open-ended. Forexample, a composition, a mixture, a process, a method, an article, oran apparatus that comprises a list of elements is not necessarilylimited to only those elements but may include other elements notexpressly listed or inherent to such composition, mixture, process,method, article, or apparatus. Further, unless expressly stated to thecontrary, “or” refers to an inclusive or and not to an exclusive or. Forexample, a condition A or B is satisfied by any one of the following: Ais true (or present) and B is false (or not present), A is false (or notpresent) and B is true (or present), and both A and B are true (orpresent).

Also, the indefinite articles “a” and “an” preceding an element orcomponent of the invention are intended to be nonrestrictive regardingthe number of instances, i.e., occurrences of the element or component.Therefore “a” or “an” should be read to include one or at least one, andthe singular word form of the element or component also includes theplural unless the number is obviously meant to be singular.

The term “invention” or “present invention” as used herein is anon-limiting term and is not intended to refer to any single embodimentof the particular invention but encompasses all possible embodiments asdescribed in the application.

As used herein, the term “about” modifying the quantity of an ingredientor reactant of the invention employed refers to variation in thenumerical quantity that can occur, for example, through typicalmeasuring and liquid handling procedures used for making concentrates oruse solutions in the real world; through inadvertent error in theseprocedures; through differences in the manufacture, source, or purity ofthe ingredients employed to make the compositions or to carry out themethods; and the like. The term “about” also encompasses amounts thatdiffer due to different equilibrium conditions for a compositionresulting from a particular initial mixture. Whether or not modified bythe term “about”, the claims include equivalents to the quantities. Inone embodiment, the term “about” means within 10% of the reportednumerical value, preferably within 5% of the reported numerical value.

The term “butanol” as used herein, refers to 2-butanol, 1-butanol,isobutanol, or mixtures thereof.

The term “pyruvate-utilizing biosynthetic pathway” refers to an enzymepathway to produce a biosynthetic product from pyruvate.

The term “isobutanol biosynthetic pathway” refers to an enzyme pathwayto produce isobutanol from pyruvate.

The term “2-butanol biosynthetic pathway” refers to an enzyme pathway toproduce 2-butanol from pyruvate.

The term “2-butanone biosynthetic pathway” refers to an enzyme pathwayto produce 2-butanone from pyruvate.

The terms “pdc−,” “PDC knock-out,” or “PDC-KO” as used herein refer to acell that has a genetic modification to inactivate or reduce expressionof at least one gene encoding pyruvate decarboxylase (PDC) so that thecell substantially or completely lacks pyruvate decarboxylase enzymeactivity. If the cell has more than one expressed (active) PDC gene,then each of the active PDC genes may be inactivated or have minimalexpression thereby producing a pdc− cell.

The term “carbon substrate” refers to a carbon source capable of beingmetabolized by the recombinant host cells disclosed herein. Non-limitingexamples of carbon substrates are provided herein and include, but arenot limited to, monosaccharides, oligosaccharides, polysaccharides,ethanol, lactate, succinate, glycerol, carbon dioxide, methanol,glucose, fructose, sucrose, xylose, arabinose, dextrose, or mixturesthereof.

The term “exogenous two-carbon substrate” refers to the carbon sourceprovided to be metabolized into acetyl-CoA by a host cell that lacks theability to convert pyruvic acid into acetyl-CoA. The term is used todistinguish from the carbon substrate which is converted into apyruvate-derived product by a pyruvate-utilizing biosynthetic pathway,herein also referred to as the “pathway substrate” which includes, forexample, glucose.

The term “polynucleotide” is intended to encompass a singular nucleicacid as well as plural nucleic acids, and refers to a nucleic acidmolecule or construct, e.g., messenger RNA (mRNA) or plasmid DNA (pDNA).A polynucleotide can contain the nucleotide sequence of the full-lengthcDNA sequence, or a fragment thereof, including the untranslated 5′ and3′ sequences and the coding sequences. The polynucleotide can becomposed of any polyribonucleotide or polydeoxyribonucleotide, which maybe unmodified RNA or DNA or modified RNA or DNA. For example,polynucleotides can be composed of single- and double-stranded DNA, DNAthat is a mixture of single- and double-stranded regions, single- anddouble-stranded RNA, and RNA that is mixture of single- anddouble-stranded regions, hybrid molecules comprising DNA and RNA thatmay be single-stranded or, more typically, double-stranded or a mixtureof single- and double-stranded regions. “Polynucleotide” embraceschemically, enzymatically, or metabolically modified forms.

A polynucleotide sequence may be referred to as “isolated,” in which ithas been removed from its native environment. For example, aheterologous polynucleotide encoding a polypeptide or polypeptidefragment having dihydroxy-acid dehydratase activity contained in avector is considered isolated for the purposes of the present invention.Further examples of an isolated polynucleotide include recombinantpolynucleotides maintained in heterologous host cells or purified(partially or substantially) polynucleotides in solution. Isolatedpolynucleotides or nucleic acids according to the present inventionfurther include such molecules produced synthetically. An isolatedpolynucleotide fragment in the form of a polymer of DNA may be comprisedof one or more segments of cDNA, genomic DNA or synthetic DNA.

The term “gene” refers to a nucleic acid fragment that is capable ofbeing expressed as a specific protein, optionally including regulatorysequences preceding (5′ non-coding sequences) and following (3′non-coding sequences) the coding sequence. “Native gene” refers to agene as found in nature with its own regulatory sequences. “Endogenousgene” refers to a native gene in its natural location in the genome ofan organism. A “heterologous gene” refers to a gene not normally foundin the host organism, but that is introduced into the host organism bygene transfer. “Heterologous gene” includes a native coding region, orportion thereof, that is reintroduced into the source organism in a formthat is different from the corresponding native gene. For example, aheterologous gene may include a native coding region that is a portionof a chimeric gene including non-native regulatory regions that isreintroduced into the native host. Foreign genes can comprise nativegenes inserted into a non-native organism, or chimeric genes.

As used herein the term “coding region” refers to a DNA sequence thatcodes for a specific amino acid sequence. “Suitable regulatorysequences” refer to nucleotide sequences located upstream (5′ non-codingsequences), within, or downstream (3′ non-coding sequences) of a codingsequence, and which influence the transcription, RNA processing orstability, or translation of the associated coding sequence. Regulatorysequences may include promoters, translation leader sequences, introns,polyadenylation recognition sequences, RNA processing site, effectorbinding site and stem-loop structure.

As used herein, the term “polypeptide” is intended to encompass asingular “polypeptide” as well as plural “polypeptides,” and refers to amolecule composed of monomers (amino acids) linearly linked by amidebonds (also known as peptide bonds). The term “polypeptide” refers toany chain or chains of two or more amino acids, and does not refer to aspecific length of the product. Thus, peptides, dipeptides, tripeptides,oligopeptides, “protein,” “amino acid chain,” or any other term used torefer to a chain or chains of two or more amino acids, are includedwithin the definition of “polypeptide,” and the term “polypeptide” maybe used instead of, or interchangeably with any of these terms. Apolypeptide may be derived from a natural biological source or producedby recombinant technology, but is not necessarily translated from adesignated nucleic acid sequence. It may be generated in any manner,including by chemical synthesis.

By an “isolated” polypeptide or a fragment, variant, or derivativethereof is intended a polypeptide that is not in its natural milieu. Noparticular level of purification is required. For example, an isolatedpolypeptide can be removed from its native or natural environment.Recombinantly produced polypeptides and proteins expressed in host cellsare considered isolated for purposed of the invention, as are native orrecombinant polypeptides which have been separated, fractionated, orpartially or substantially purified by any suitable technique.

As used herein, the term “variant” refers to a polypeptide differingfrom a specifically recited polypeptide of the invention by amino acidinsertions, deletions, mutations, and substitutions, created using,e.g., recombinant DNA techniques, such as mutagenesis. Guidance indetermining which amino acid residues may be replaced, added, or deletedwithout abolishing activities of interest, may be found by comparing thesequence of the particular polypeptide with that of homologouspolypeptides, e.g., yeast or bacterial, and minimizing the number ofamino acid sequence changes made in regions of high homology (conservedregions) or by replacing amino acids with consensus sequences.

Alternatively, recombinant polynucleotide variants encoding these sameor similar polypeptides may be synthesized or selected by making use ofthe “redundancy” in the genetic code. Various codon substitutions, suchas silent changes which produce various restriction sites, may beintroduced to optimize cloning into a plasmid or viral vector forexpression. Mutations in the polynucleotide sequence may be reflected inthe polypeptide or domains of other peptides added to the polypeptide tomodify the properties of any part of the polypeptide.

Amino acid “substitutions” may be the result of replacing one amino acidwith another amino acid having similar structural and/or chemicalproperties, i.e., conservative amino acid replacements, or they may bethe result of replacing one amino acid with an amino acid havingdifferent structural and/or chemical properties, i.e., non-conservativeamino acid replacements. “Conservative” amino acid substitutions may bemade on the basis of similarity in polarity, charge, solubility,hydrophobicity, hydrophilicity, or the amphipathic nature of theresidues involved. For example, nonpolar (hydrophobic) amino acidsinclude alanine, leucine, isoleucine, valine, proline, phenylalanine,tryptophan, and methionine; polar neutral amino acids include glycine,serine, threonine, cysteine, tyrosine, asparagine, and glutamine;positively charged (basic) amino acids include arginine, lysine, andhistidine; and negatively charged (acidic) amino acids include asparticacid and glutamic acid. Alternatively, “non-conservative” amino acidsubstitutions may be made by selecting the differences in polarity,charge, solubility, hydrophobicity, hydrophilicity, or the amphipathicnature of any of these amino acids. “Insertions” or “deletions” may bewithin the range of variation as structurally or functionally toleratedby the recombinant proteins. The variation allowed may be experimentallydetermined by systematically making insertions, deletions, orsubstitutions of amino acids in a polypeptide molecule using recombinantDNA techniques and assaying the resulting recombinant variants foractivity.

The term “promoter” refers to a DNA sequence capable of controlling theexpression of a coding sequence or functional RNA. In general, a codingsequence is located 3′ to a promoter sequence. Promoters may be derivedin their entirety from a native gene, or be composed of differentelements derived from different promoters found in nature, or evencomprise synthetic DNA segments. It is understood by those skilled inthe art that different promoters may direct the expression of a gene indifferent tissues or cell types, or at different stages of development,or in response to different environmental or physiological conditions.Promoters which cause a gene to be expressed in most cell types at mosttimes are commonly referred to as “constitutive promoters.” It isfurther recognized that since in most cases the exact boundaries ofregulatory sequences have not been completely defined, DNA fragments ofdifferent lengths may have identical promoter activity. For example, itwill be understood that “FBA1 promoter” can be used to refer to afragment derived from the promoter region of the FBA1 gene.

The term “terminator” as used herein refers to DNA sequences locateddownstream of a coding sequence. This includes polyadenylationrecognition sequences and other sequences encoding regulatory signalscapable of affecting mRNA processing or gene expression. Thepolyadenylation signal is usually characterized by affecting theaddition of polyadenylic acid tracts to the 3′ end of the mRNAprecursor. The 3′ region can influence the transcription, RNA processingor stability, or translation of the associated coding sequence. It isrecognized that since in most cases the exact boundaries of regulatorysequences have not been completely defined, DNA fragments of differentlengths may have identical terminator activity. For example, it will beunderstood that “CYC1 terminator” can be used to refer to a fragmentderived from the terminator region of the CYC1 gene.

The term “operably linked” refers to the association of nucleic acidsequences on a single nucleic acid fragment so that the function of oneis affected by the other. For example, a promoter is operably linkedwith a coding sequence when it is capable of effecting the expression ofthat coding sequence (i.e., that the coding sequence is under thetranscriptional control of the promoter). Coding sequences can beoperably linked to regulatory sequences in sense or antisenseorientation.

The term “expression,” as used herein, refers to the transcription andstable accumulation of sense (mRNA) or antisense RNA derived from thenucleic acid fragment of the invention. Expression may also refer totranslation of mRNA into a polypeptide.

The term “overexpression,” as used herein, refers to expression that ishigher than endogenous expression of the same or related gene. Aheterologous gene is overexpressed if its expression is higher than thatof a comparable endogenous gene.

As used herein the term “transformation” refers to the transfer of anucleic acid fragment into a host organism, resulting in geneticallystable inheritance. Host organisms containing the transformed nucleicacid fragments are referred to as “transgenic” or “recombinant” or“transformed” organisms.

The terms “plasmid” and “vector” as used herein, refer to an extrachromosomal element often carrying genes which are not part of thecentral metabolism of the cell, and usually in the form of circulardouble-stranded DNA molecules. Such elements may be autonomouslyreplicating sequences, genome integrating sequences, phage or nucleotidesequences, linear or circular, of a single- or double-stranded DNA orRNA, derived from any source, in which a number of nucleotide sequenceshave been joined or recombined into a unique construction which iscapable of introducing a promoter fragment and DNA sequence for aselected gene product along with appropriate 3′ untranslated sequenceinto a cell.

As used herein the term “codon degeneracy” refers to the nature in thegenetic code permitting variation of the nucleotide sequence withoutaffecting the amino acid sequence of an encoded polypeptide. The skilledartisan is well aware of the “codon-bias” exhibited by a specific hostcell in usage of nucleotide codons to specify a given amino acid.Therefore, when synthesizing a gene for improved expression in a hostcell, it is desirable to design the gene such that its frequency ofcodon usage approaches the frequency of preferred codon usage of thehost cell.

The term “codon-optimized” as it refers to genes or coding regions ofnucleic acid molecules for transformation of various hosts, refers tothe alteration of codons in the gene or coding regions of the nucleicacid molecules to reflect the typical codon usage of the host organismwithout altering the polypeptide encoded by the DNA. Such optimizationincludes replacing at least one, or more than one, or a significantnumber, of codons with one or more codons that are more frequently usedin the genes of that organism.

Deviations in the nucleotide sequence that comprise the codons encodingthe amino acids of any polypeptide chain allow for variations in thesequence coding for the gene. Since each codon consists of threenucleotides, and the nucleotides comprising DNA are restricted to fourspecific bases, there are 64 possible combinations of nucleotides, 61 ofwhich encode amino acids (the remaining three codons encode signalsending translation). The “genetic code” which shows which codons encodewhich amino acids is reproduced herein as Table 1. As a result, manyamino acids are designated by more than one codon. For example, theamino acids alanine and proline are coded for by four triplets, serineand arginine by six, whereas tryptophan and methionine are coded by justone triplet. This degeneracy allows for DNA base composition to varyover a wide range without altering the amino acid sequence of theproteins encoded by the DNA.

TABLE 1 The Standard Genetic Code T C A G T TTT Phe (F) TCT Ser (S)TAT Tyr (Y) TGT Cys (C) TTC Phe (F) TCC Ser (S) TAC Tyr (Y) TGCTTA Leu (L) TCA Ser (S) TAA Stop TGA Stop TTG Leu (L) TCG Ser (S)TAG Stop TGG Trp (W) C CTT Leu (L) CCT Pro (P) CAT His (H) CGT Arg (R)CTC Leu (L) CCC Pro (P) CAC His (H) CGC Arg (R) CTA Leu (L) CCA Pro (P)CAA Gln (Q) CGA Arg (R) CTG Leu (L) CCG Pro (P) CAG Gln (Q) CGG Arg (R)A ATT Ile (I) ACT Thr (T) AAT Asn (N) AGT Ser (S) ATC Ile (I)ACC Thr (T) AAC Asn (N) AGC Ser (S) ATA Ile (I) ACA Thr (T) AAA Lys (K)AGA Arg (R) ATG Met (M) ACG Thr (T) AAG Lys (K) AGG Arg (R) GGTT Val (V) GCT Ala (A) GAT Asp (D) GGT Gly (G) GTC Val (V) GCC Ala (A)GAC Asp (D) GGC Gly (G) GTA Val (V) GCA Ala (A) GAA Glu (E) GGA Gly (G)GTG Val (V) GCG Ala (A) GAG Glu (E) GGG Gly (G)

Many organisms display a bias for use of particular codons to code forinsertion of a particular amino acid in a growing peptide chain. Codonpreference, or codon bias, differences in codon usage between organisms,is afforded by degeneracy of the genetic code, and is well documentedamong many organisms. Codon bias often correlates with the efficiency oftranslation of messenger RNA (mRNA), which is in turn believed to bedependent on, inter alia, the properties of the codons being translatedand the availability of particular transfer RNA (tRNA) molecules. Thepredominance of selected tRNAs in a cell is generally a reflection ofthe codons used most frequently in peptide synthesis. Accordingly, genescan be tailored for optimal gene expression in a given organism based oncodon optimization.

Given the large number of gene sequences available for a wide variety ofanimal, plant and microbial species, it is possible to calculate therelative frequencies of codon usage. Codon usage tables are readilyavailable, for example, at the “Codon Usage Database” available athttp://www.kazusa.or.jp/codon/ (visited Mar. 20, 2008), and these tablescan be adapted in a number of ways. See Nakamura, Y., et al. Nucl. AcidsRes. 28:292 (2000). Codon usage tables for yeast, calculated fromGenBank Release 128.0 [15 Feb. 2002], are reproduced below as Table 2.This table uses mRNA nomenclature, and so instead of thymine (T) whichis found in DNA, the tables use uracil (U) which is found in RNA. Table2 has been adapted so that frequencies are calculated for each aminoacid, rather than for all 64 codons.

TABLE 2 Codon Usage Table for Saccharomyces cerevisiae Genes Frequencyper Amino Acid Codon Number thousand Phe UUU 170666 26.1 Phe UUC 12051018.4 Leu UUA 170884 26.2 Leu UUG 177573 27.2 Leu CUU 80076 12.3 Leu CUC35545 5.4 Leu CUA 87619 13.4 Leu CUG 68494 10.5 Ile AUU 196893 30.1 IleAUC 112176 17.2 Ile AUA 116254 17.8 Met AUG 136805 20.9 Val GUU 14424322.1 Val GUC 76947 11.8 Val GUA 76927 11.8 Val GUG 70337 10.8 Ser UCU153557 23.5 Ser UCC 92923 14.2 Ser UCA 122028 18.7 Ser UCG 55951 8.6 SerAGU 92466 14.2 Ser AGC 63726 9.8 Pro CCU 88263 13.5 Pro CCC 44309 6.8Pro CCA 119641 18.3 Pro CCG 34597 5.3 Thr ACU 132522 20.3 Thr ACC 8320712.7 Thr ACA 116084 17.8 Thr ACG 52045 8.0 Ala GCU 138358 21.2 Ala GCC82357 12.6 Ala GCA 105910 16.2 Ala GCG 40358 6.2 Tyr UAU 122728 18.8 TyrUAC 96596 14.8 His CAU 89007 13.6 His CAC 50785 7.8 Gln CAA 178251 27.3Gln CAG 79121 12.1 Asn AAU 233124 35.7 Asn AAC 162199 24.8 Lys AAA273618 41.9 Lys AAG 201361 30.8 Asp GAU 245641 37.6 Asp GAC 132048 20.2Glu GAA 297944 45.6 Glu GAG 125717 19.2 Cys UGU 52903 8.1 Cys UGC 310954.8 Trp UGG 67789 10.4 Arg CGU 41791 6.4 Arg CGC 16993 2.6 Arg CGA 195623.0 Arg CGG 11351 1.7 Arg AGA 139081 21.3 Arg AGG 60289 9.2 Gly GGU156109 23.9 Gly GGC 63903 9.8 Gly GGA 71216 10.9 Gly GGG 39359 6.0 StopUAA 6913 1.1 Stop UAG 3312 0.5 Stop UGA 4447 0.7

By utilizing this or similar tables, one of ordinary skill in the artcan apply the frequencies to any given polypeptide sequence, and producea nucleic acid fragment of a codon-optimized coding region which encodesthe polypeptide, but which uses codons optimal for a given species.

Randomly assigning codons at an optimized frequency to encode a givenpolypeptide sequence, can be done manually by calculating codonfrequencies for each amino acid, and then assigning the codons to thepolypeptide sequence randomly. Additionally, various algorithms andcomputer software programs are readily available to those of ordinaryskill in the art. For example, the “EditSeq” function in the LasergenePackage, available from DNAstar, Inc., Madison, Wis., thebacktranslation function in the Vector NTI Suite, available fromInforMax, Inc., Bethesda, Md., and the “backtranslate” function in theGCG-Wisconsin Package, available from Accelrys, Inc., San Diego, Calif.In addition, various resources are publicly available to codon-optimizecoding region sequences, e.g., the “backtranslation” function athttp://www.entelechon.com/bioinformatics/backtranslation.php?lang=eng(visited Apr. 15, 2008) and the “backtranseq” function available athttp://bioinfo.pbi.nrc.ca:8090/EMBOSS/index.html (visited Jul. 9, 2002).Constructing a rudimentary algorithm to assign codons based on a givenfrequency can also easily be accomplished with basic mathematicalfunctions by one of ordinary skill in the art.

Codon-optimized coding regions can be designed by various methods knownto those skilled in the art including software packages such as“synthetic gene designer”(http://phenotype.biosci.umbc.edu/codon/sgd/index.php).

A polynucleotide or nucleic acid fragment is “hybridizable” to anothernucleic acid fragment, such as a cDNA, genomic DNA, or RNA molecule,when a single-stranded form of the nucleic acid fragment can anneal tothe other nucleic acid fragment under the appropriate conditions oftemperature and solution ionic strength. Hybridization and washingconditions are well known and exemplified in Sambrook, J., Fritsch, E.F. and Maniatis, T. Molecular Cloning: A Laboratory Manual, 2^(nd) ed.,Cold Spring Harbor Laboratory: Cold Spring Harbor, N.Y. (1989),particularly Chapter 11 and Table 11.1 therein (entirely incorporatedherein by reference). The conditions of temperature and ionic strengthdetermine the “stringency” of the hybridization. Stringency conditionscan be adjusted to screen for moderately similar fragments (such ashomologous sequences from distantly related organisms), to highlysimilar fragments (such as genes that duplicate functional enzymes fromclosely related organisms). Post-hybridization washes determinestringency conditions. One set of preferred conditions uses a series ofwashes starting with 6×SSC, 0.5% SDS at room temperature for 15 min,then repeated with 2×SSC, 0.5% SDS at 45° C. for 30 min, and thenrepeated twice with 0.2×SSC, 0.5% SDS at 50° C. for 30 min. A morepreferred set of stringent conditions uses higher temperatures in whichthe washes are identical to those above except for the temperature ofthe final two 30 min washes in 0.2×SSC, 0.5% SDS was increased to 60° C.Another preferred set of highly stringent conditions uses two finalwashes in 0.1×SSC, 0.1% SDS at 65° C. An additional set of stringentconditions include hybridization at 0.1×SSC, 0.1% SDS, 65° C. and washeswith 2×SSC, 0.1% SDS followed by 0.1×SSC, 0.1% SDS, for example.

Hybridization requires that the two nucleic acids contain complementarysequences, although depending on the stringency of the hybridization,mismatches between bases are possible. The appropriate stringency forhybridizing nucleic acids depends on the length of the nucleic acids andthe degree of complementation, variables well known in the art. Thegreater the degree of similarity or homology between two nucleotidesequences, the greater the value of Tm for hybrids of nucleic acidshaving those sequences. The relative stability (corresponding to higherTm) of nucleic acid hybridizations decreases in the following order:RNA:RNA, DNA:RNA, DNA:DNA. For hybrids of greater than 100 nucleotidesin length, equations for calculating Tm have been derived (see Sambrooket al., supra, 9.50-9.51). For hybridizations with shorter nucleicacids, i.e., oligonucleotides, the position of mismatches becomes moreimportant, and the length of the oligonucleotide determines itsspecificity (see Sambrook et al., supra, 11.7-11.8). In one embodimentthe length for a hybridizable nucleic acid is at least about 10nucleotides. Preferably a minimum length for a hybridizable nucleic acidis at least about 15 nucleotides; more preferably at least about 20nucleotides; and most preferably the length is at least about 30nucleotides. Furthermore, the skilled artisan will recognize that thetemperature and wash solution salt concentration may be adjusted asnecessary according to factors such as length of the probe.

A “substantial portion” of an amino acid or nucleotide sequence is thatportion comprising enough of the amino acid sequence of a polypeptide orthe nucleotide sequence of a gene to putatively identify thatpolypeptide or gene, either by manual evaluation of the sequence by oneskilled in the art, or by computer-automated sequence comparison andidentification using algorithms such as BLAST (Altschul, S. F., et al.,J. Mol. Biol., 215:403-410 (1993)). In general, a sequence of ten ormore contiguous amino acids or thirty or more nucleotides is necessaryin order to putatively identify a polypeptide or nucleic acid sequenceas homologous to a known protein or gene. Moreover, with respect tonucleotide sequences, gene specific oligonucleotide probes comprising20-30 contiguous nucleotides may be used in sequence-dependent methodsof gene identification (e.g., Southern hybridization) and isolation(e.g., in situ hybridization of bacterial colonies or bacteriophageplaques). In addition, short oligonucleotides of 12-15 bases may be usedas amplification primers in PCR in order to obtain a particular nucleicacid fragment comprising the primers. Accordingly, a “substantialportion” of a nucleotide sequence comprises enough of the sequence tospecifically identify and/or isolate a nucleic acid fragment comprisingthe sequence. The instant specification teaches the complete amino acidand nucleotide sequence encoding particular proteins. The skilledartisan, having the benefit of the sequences as reported herein, may nowuse all or a substantial portion of the disclosed sequences for purposesknown to those skilled in this art. Accordingly, the instant inventioncomprises the complete sequences as reported in the accompanyingSequence Listing, as well as substantial portions of those sequences asdefined above.

The term “complementary” is used to describe the relationship betweennucleotide bases that are capable of hybridizing to one another. Forexample, with respect to DNA, adenosine is complementary to thymine andcytosine is complementary to guanine.

The term “percent identity”, as known in the art, is a relationshipbetween two or more polypeptide sequences or two or more polynucleotidesequences, as determined by comparing the sequences. In the art,“identity” also means the degree of sequence relatedness betweenpolypeptide or polynucleotide sequences, as the case may be, asdetermined by the match between strings of such sequences. “Identity”and “similarity” can be readily calculated by known methods, includingbut not limited to those described in: 1.) Computational MolecularBiology (Lesk, A. M., Ed.) Oxford University: NY (1988); 2.)Biocomputing: Informatics and Genome Projects (Smith, D. W., Ed.)Academic: NY (1993); 3.) Computer Analysis of Sequence Data, Part I(Griffin, A. M., and Griffin, H. G., Eds.) Humania: NJ (1994); 4.)Sequence Analysis in Molecular Biology (von Heinje, G., Ed.) Academic(1987); and 5.) Sequence Analysis Primer (Gribskov, M. and Devereux, J.,Eds.) Stockton: NY (1991).

Preferred methods to determine identity are designed to give the bestmatch between the sequences tested. Methods to determine identity andsimilarity are codified in publicly available computer programs.Sequence alignments and percent identity calculations may be performedusing the MegAlign™ program of the LASERGENE bioinformatics computingsuite (DNASTAR Inc., Madison, Wis.). Multiple alignment of the sequencesis performed using the “Clustal method of alignment” which encompassesseveral varieties of the algorithm including the “Clustal V method ofalignment” corresponding to the alignment method labeled Clustal V(described by Higgins and Sharp, CABIOS. 5:151-153 (1989); Higgins, D.G. et al., Comput. Appl. Biosci., 8:189-191 (1992)) and found in theMegAlign™ program of the LASERGENE bioinformatics computing suite(DNASTAR Inc.). For multiple alignments, the default values correspondto GAP PENALTY=10 and GAP LENGTH PENALTY=10. Default parameters forpairwise alignments and calculation of percent identity of proteinsequences using the Clustal method are KTUPLE=1, GAP PENALTY=3, WINDOW=5and DIAGONALS SAVED=5. For nucleic acids these parameters are KTUPLE=2,GAP PENALTY=5, WINDOW=4 and DIAGONALS SAVED=4. After alignment of thesequences using the Clustal V program, it is possible to obtain a“percent identity” by viewing the “sequence distances” table in the sameprogram. Additionally the “Clustal W method of alignment” is availableand corresponds to the alignment method labeled Clustal W (described byHiggins and Sharp, CABIOS. 5:151-153 (1989); Higgins, D. G. et al.,Comput. Appl. Biosci. 8:189-191 (1992)) and found in the MegAlign™ v6.1program of the LASERGENE bioinformatics computing suite (DNASTAR Inc.).Default parameters for multiple alignment (GAP PENALTY=10, GAP LENGTHPENALTY=0.2, Delay Divergen Seqs (%)=30, DNA Transition Weight=0.5,Protein Weight Matrix=Gonnet Series, DNA Weight Matrix=IUB). Afteralignment of the sequences using the Clustal W program, it is possibleto obtain a “percent identity” by viewing the “sequence distances” tablein the same program.

It is well understood by one skilled in the art that many levels ofsequence identity are useful in identifying polypeptides, such as fromother species, wherein such polypeptides have the same or similarfunction or activity. Useful examples of percent identities include, butare not limited to: 55%, 60%, 65%, 70%, 75%, 80%, 85%, 90%, or 95%, orany integer percentage from 55% to 100% may be useful in describing thepresent invention, such as 55%, 56%, 57%, 58%, 59%, 60%, 61%, 62%, 63%,64%, 65%, 66%, 67%, 68%, 69%, 70%, 71%, 72%, 73%, 74%, 75%, 76%, 77%,78%, 79%, 80%, 81%, 82%, 83%, 84%, 85%, 86%, 87%, 88%, 89%, 90%, 91%,92%, 93%, 94%, 95%, 96%, 97%, 98% or 99%. Suitable nucleic acidfragments not only have the above homologies but typically encode apolypeptide having at least 50 amino acids, preferably at least 100amino acids, more preferably at least 150 amino acids, still morepreferably at least 200 amino acids, and most preferably at least 250amino acids.

The term “sequence analysis software” refers to any computer algorithmor software program that is useful for the analysis of nucleotide oramino acid sequences. “Sequence analysis software” may be commerciallyavailable or independently developed. Typical sequence analysis softwarewill include, but is not limited to: 1.) the GCG suite of programs(Wisconsin Package Version 9.0, Genetics Computer Group (GCG), Madison,Wis.); 2.) BLASTP, BLASTN, BLASTX (Altschul et al., J. Mol. Biol.,215:403-410 (1990)); 3.) DNASTAR (DNASTAR, Inc. Madison, Wis.); 4.)Sequencher (Gene Codes Corporation, Ann Arbor, Mich.); and 5.) the FASTAprogram incorporating the Smith-Waterman algorithm (W. R. Pearson,Comput. Methods Genome Res., [Proc. Int. Symp.] (1994), Meeting Date1992, 111-20. Editor(s): Suhai, Sandor. Plenum: New York, N.Y.). Withinthe context of this application it will be understood that wheresequence analysis software is used for analysis, that the results of theanalysis will be based on the “default values” of the programreferenced, unless otherwise specified. As used herein “default values”will mean any set of values or parameters that originally load with thesoftware when first initialized.

Standard recombinant DNA and molecular cloning techniques used here arewell known in the art and are described by Sambrook, J., Fritsch, E. F.and Maniatis, T., Molecular Cloning: A Laboratory Manual, SecondEdition, Cold Spring Harbor Laboratory Press, Cold Spring Harbor, N.Y.(1989) (hereinafter “Maniatis”); and by Silhavy, T. J., Bennan, M. L.and Enquist, L. W., Experiments with Gene Fusions, Cold Spring HarborLaboratory Press, Cold Spring Harbor, N.Y. (1984); and by Ausubel, F. M.et al., Current Protocols in Molecular Biology, published by GreenePublishing Assoc. and Wiley-Interscience (1987). Additional methods usedhere are in Methods in Enzymology, Volume 194, Guide to Yeast Geneticsand Molecular and Cell Biology (Part A, 2004, Christine Guthrie andGerald R. Fink (Eds.), Elsevier Academic Press, San Diego, Calif.).Other molecular tools and techniques are known in the art and includesplicing by overlapping extension polymerase chain reaction (PCR) (Yu,et al. (2004) Fungal Genet. Biol. 41:973-981), positive selection formutations at the URA3 locus of Saccharomyces cerevisiae (Boeke, J. D. etal. (1984) Mol. Gen. Genet. 197, 345-346; M A Romanos, et al. NucleicAcids Res. 1991 Jan. 11; 19(1): 187), the cre-lox site-specificrecombination system as well as mutant lox sites and FLP substratemutations (Sauer, B. (1987) Mol Cell Biol 7: 2087-2096; Senecoff, et al.(1988) Journal of Molecular Biology, Volume 201, Issue 2, Pages 405-421;Albert, et al. (1995) The Plant Journal. Volume 7, Issue 4, pages649-659), “seamless” gene deletion (Akada, et al. (2006) Yeast;23(5):399-405), andgap repair methodology (Ma et al., Genetics58:201-216; 1981). Applicants have discovered that activation of thephosphoketolase pathway in a recombinant host cell comprising amodification in an endogenous gene encoding a polypeptide havingpyruvate decarboxylase activity or a modification in an endogenouspolypeptide having pyruvate decarboxylase activity, reduces oreliminates the need for an exogenous carbon substrate for the growth ofsuch a cell. In embodiments, the recombinant host cells comprise (i) atleast one deletion, mutation and/or substitution in an endogenous geneencoding a polypeptide having pyruvate decarboxylase activity); (ii) aheterologous polynucleotide encoding a polypeptide havingphosphoketolase activity; and optionally (iii) a heterologouspolynucleotide encoding a polypeptide having phosphotransacetylaseactivity.

The genetic manipulations of the host cells described herein can beperformed using standard genetic techniques and screening and can bemade in any host cell that is suitable to genetic manipulation (Methodsin Yeast Genetics, 2005, Cold Spring Harbor Laboratory Press, ColdSpring Harbor, N.Y., pp. 201-202). In embodiments, the recombinant hostcells disclosed herein can be any bacteria, yeast or fungi host usefulfor genetic modification and recombinant gene expression. In otherembodiments, a recombinant host cell can be a member of the generaClostridium, Zymomonas, Escherichia, Salmonella, Serratia, Erwinia,Klebsiella, Shigella, Rhodococcus, Pseudomonas, Bacillus, Lactobacillus,Enterococcus, Alcaligenes, Klebsiella, Paenibacillus, Arthrobacter,Corynebacterium, Brevibacterium, Schizosaccharomyces, Kluyveromyces,Yarrowia, Pichia, Candida, Hansenula, Issatchenkia, or Saccharomyces. Inother embodiments, the host cell can be Saccharomyces cerevisiae,Schizosaccharomyces pombe, Kluyveromyces lactis, Kluyveromycesthermotolerans, Kluyveromyces marxianus, Candida glabrata, Candidaalbicans, Pichia stipitis, Yarrowia lipolytica, E. coli, or L.plantarum. In still other embodiments, the host cell is a yeast hostcell. In some embodiments, the host cell is a member of the generaSaccharomyces. In some embodiments, the host cell is Kluyveromyceslactis, Candida glabrata or Schizosaccharomyces pombe. In someembodiments, the host cell is Saccharomyces cerevisiae. S. cerevisiaeyeast are known in the art and are available from a variety of sources,including, but not limited to, American Type Culture Collection(Rockville, Md.), Centraalbureau voor Schimmelcultures (CBS) FungalBiodiversity Centre, LeSaffre, Gert Strand AB, Ferm Solutions, NorthAmerican Bioproducts, Martrex, and Lallemand. S. cerevisiae include, butare not limited to, BY4741, CEN.PK 113-7D, Ethanol Red® yeast, Ferm Pro™yeast, Bio-Ferm® XR yeast, Gert Strand Prestige Batch Turbo alcoholyeast, Gert Strand Pot Distillers yeast, Gert Strand Distillers Turboyeast, FerMax™ Green yeast, FerMax™ Gold yeast, Thermosacc® yeast, BG-1,PE-2, CAT-1, CBS7959, CBS7960, and CBS7961.

Sources of Acetyl-CoA

Acetyl-CoA is a major cellular building block, required for thesynthesis of fatty acids, sterols, and lysine. Pyruvate is often a majorcontributor to the acetyl-CoA pool. Pyruvate dehydrogenase catalyzes thedirect conversion of pyruvate to acetyl-CoA (E.C. 1.2.4.1, E.C.1.2.1.51) or acetate (E.C. 1.2.2.2) and is almost ubiquitous in nature.Other enzymes involved in conversion of pyruvate to acetyl-CoA,acetyl-phosphate or acetate include pyruvate-formate lyase (E.C.2.3.1.54), pyruvate oxidase (E.C. 1.2.3.3, E.C. 1.2.3.6),pyruvate-ferredoxin oxidoreductase (E.C. 1.2.7.1), and pyruvatedecarboxylase (E.C. 4.1.1.1). Genetic modifications made to a host cellto conserve the pyruvate pool for a product of interest may includethose that restrict conversion to acetyl-CoA, leading to decreasedgrowth in the absence of an exogenously supplied two-carbon substrate, acarbon substrate that can be readily converted to acetyl-CoA independentof pyruvate (e.g. ethanol or acetate). An example is the documentedauxotrophy observed in pyruvate decarboxylase deficient Saccharomycescerevisiae (Flikweert et al. 1999, supra). Another example is thedocumented auxotrophy observed in pyruvate dehydrogenase deficientEscherichia coli when grown aerobically on glucose (Langley and Guest,1977, J. Gen. Microbiol. 99:2630276).

Modification of Pyruvate Decarboxylase

In embodiments, the recombinant host cells disclosed herein comprise amodification in an endogenous polynucleotide encoding a polypeptidehaving pyruvate decarboxylase (PDC) or a modification in an endogenouspolypeptide having PDC activity. In embodiments, the recombinant hostcells disclosed herein can have a modification or disruption of one ormore polynucleotides, genes or polypeptides encoding PDC. Inembodiments, the recombinant host cell comprises at least one deletion,mutation, and/or substitution in one or more endogenous polynucleotidesor genes encoding a polypeptide having PDC activity, or in one or moreendogenous polypeptides having PDC activity. Such modifications,disruptions, deletions, mutations, and/or substitutions can result inPDC activity that is reduced or eliminated, resulting in a PDC knock-out(PDC-KO) phenotype.

In embodiments, the endogenous pyruvate decarboxylase activity of therecombinant host cells disclosed herein converts pyruvate toacetaldehyde, which can then be converted to ethanol or to acetyl-CoAvia acetate.

In embodiments, the recombinant host cell is Kluyveromyces lactiscontaining one gene encoding pyruvate decarboxylase, Candida glabratacontaining one gene encoding pyruvate decarboxylase, orSchizosaccharomyces pombe containing one gene encoding pyruvatedecarboxylase.

In other embodiments, the recombinant host cell is Saccharomycescerevisiae containing three isozymes of pyruvate decarboxylase encodedby the pdc1, pdc5, and pdc6 genes, as well as a pyruvate decarboxylaseregulatory gene, pdc2. In a non-limiting example in S. cerevisiae, thepdc1 and pdc5 genes, or all three genes, are disrupted. In anothernon-limiting example in S. cerevisiae, pyruvate decarboxylase activitymay be reduced by disrupting the pdc2 regulatory gene. In anothernon-limiting example in S. cerevisiae, polynucleotides or genes encodingpyruvate decarboxylase proteins such as those having about 70% to about75%, about 75% to about 80%, about 80% to about 85%, about 85% to about90%, about 90% to about 95%, about 96%, about 97%, about 98%, or about99% sequence identity to pdc1 or pdc5 can be disrupted.

In embodiments, the polypeptide having PDC activity or thepolynucleotide or gene encoding a polypeptide having PDC activity isassociated with Enzyme Commission Number EC 4.1.1.1. In otherembodiments, a PDC gene of the recombinant host cells disclosed hereinis not active under the fermentation conditions used, and therefore sucha gene would not need to be modified or inactivated.

Examples of recombinant host cells with reduced pyruvate decarboxylaseactivity due to disruption of pyruvate decarboxylase encoding genes havebeen reported, such as for Saccharomyces in Flikweert et al. (Yeast(1996) 12:247-257), for Kluyveromyces in Bianchi et al. (Mol. Microbiol.(1996) 19(1):27-36), and disruption of the regulatory gene in Hohmann(Mol. Gen. Genet. (1993) 241:657-666). Saccharomyces strains having nopyruvate decarboxylase activity are available from the ATCC withAccession #200027 and #200028.

Examples of PDC polynucleotides, genes and polypeptides that can betargeted for modification or inactivation in the recombinant host cellsdisclosed herein include, but are not limited to, those of the followingtable.

TABLE 3 SEQ ID NOs of pyruvate decarboxylase (PDC) target gene codingregions and proteins. SEQ ID NO: SEQ ID NO: Description Nucleic acidAmino acid PDC1 pyruvate decarboxylase 1 2 from Saccharomyces cerevisiaePDC5 pyruvate decarboxylase 3 4 from Saccharomyces cerevisiae PDC6pyruvate decarboxylase 5 6 from Saccharomyces cerevisiae pyruvatedecarboxylase from 7 8 Candida glabrata PDC1 pyruvate decarboxylase 9 10from Pichia stipitis PDC2 pyruvate decarboxylase 11 12 from Pichiastipitis pyruvate decarboxylase from 13 14 Kluyveromyces lactis pyruvatedecarboxylase from 15 16 Yarrowia lipolytica pyruvate decarboxylase from17 18 Schizosaccharomyces pombe pyruvate decarboxylase from 18 20Zygosaccharomyces rouxii

Other examples of PDC polynucleotides, genes and polypeptides that canbe targeted for modification or inactivation in the recombinant hostcells disclosed herein include, but are not limited to, PDCpolynucleotides, genes and/or polypeptides having at least about 70% toabout 75%, about 75% to about 80%, about 80% to about 85%, about 85% toabout 90%, about 90% to about 95%, about 96%, about 97%, about 98%, orabout 99% sequence identity to any one of the sequences of Table 3.

In embodiments, the sequences of other PDC polynucleotides, genes and/orpolypeptides can be identified in the literature and in bioinformaticsdatabases well known to the skilled person using sequences disclosedherein and available in the art. For example, such sequences can beidentified through BLAST (as described above) searching of publiclyavailable databases with known PDC encoding polynucleotide orpolypeptide sequences. In such a method, identities can be based on theClustal W method of alignment using the default parameters of GAPPENALTY=10, GAP LENGTH PENALTY=0.1, and Gonnet 250 series of proteinweight matrix.

Additionally, the PDC polynucleotide or polypeptide sequences describedherein or known the art can be used to identify other PDC homologs innature. For example, each of the PDC encoding nucleic acid fragmentsdescribed herein can be used to isolate genes encoding homologousproteins. Isolation of homologous genes using sequence-dependentprotocols is well known in the art. Examples of sequence-dependentprotocols include, but are not limited to (1) methods of nucleic acidhybridization; (2) methods of DNA and RNA amplification, as exemplifiedby various uses of nucleic acid amplification technologies [e.g.,polymerase chain reaction (PCR), Mullis et al., U.S. Pat. No. 4,683,202;ligase chain reaction (LCR), Tabor, S. et al., Proc. Acad. Sci. USA82:1074 (1985); or strand displacement amplification (SDA), Walker etal., Proc. Natl. Acad. Sci. U.S.A., 89:392 (1992)]; and (3) methods oflibrary construction and screening by complementation.

In embodiments, PDC polynucleotides, genes and/or polypeptides relatedto the recombinant host cells described herein can be modified ordisrupted. Many methods for genetic modification and disruption oftarget genes to reduce or eliminate expression are known to one ofordinary skill in the art and can be used to create the recombinant hostcells described herein. Modifications that can be used include, but arenot limited to, deletion of the entire gene or a portion of the geneencoding a PDC protein, inserting a DNA fragment into the encoding gene(in either the promoter or coding region) so that the protein is notexpressed or expressed at lower levels, introducing a mutation into thecoding region which adds a stop codon or frame shift such that afunctional protein is not expressed, and introducing one or moremutations into the coding region to alter amino acids so that anon-functional or a less active protein is expressed. In otherembodiments, expression of a target gene can be blocked by expression ofan antisense RNA or an interfering RNA, and constructs can be introducedthat result in cosuppression. In other embodiments, the synthesis orstability of the transcript can be lessened by mutation. In embodiments,the efficiency by which a protein is translated from mRNA can bemodulated by mutation. All of these methods can be readily practiced byone skilled in the art making use of the known or identified sequencesencoding target proteins.

In other embodiments, DNA sequences surrounding a target PDC codingsequence are also useful in some modification procedures and areavailable, for example, for yeasts such as Saccharomyces cerevisiae inthe complete genome sequence coordinated by Genome Project ID9518 ofGenome Projects coordinated by NCBI (National Center for BiotechnologyInformation) with identifying GOPID #13838. An additional non-limitingexample of yeast genomic sequences is that of Candida albicans, which isincluded in GPID #10771, #10701 and #16373. Other yeast genomicsequences can be readily found by one of skill in the art in publiclyavailable databases.

In other embodiments, DNA sequences surrounding a target PDC codingsequence can be useful for modification methods using homologousrecombination. In a non-limiting example of this method, PDC geneflanking sequences can be placed bounding a selectable marker gene tomediate homologous recombination whereby the marker gene replaces thePDC gene. In another non-limiting example, partial PDC gene sequencesand PDC gene flanking sequences bounding a selectable marker gene can beused to mediate homologous recombination whereby the marker genereplaces a portion of the target PDC gene. In embodiments, theselectable marker can be bounded by site-specific recombination sites,so that following expression of the corresponding site-specificrecombinase, the resistance gene is excised from the PDC gene withoutreactivating the latter. In embodiments, the site-specific recombinationleaves behind a recombination site which disrupts expression of the PDCprotein. In other embodiments, the homologous recombination vector canbe constructed to also leave a deletion in the PDC gene followingexcision of the selectable marker, as is well known to one skilled inthe art.

In other embodiments, deletions can be made to a PDC target gene usingmitotic recombination as described in Wach et al. (Yeast, 10:1793-1808;1994). Such a method can involve preparing a DNA fragment that containsa selectable marker between genomic regions that can be as short as 20bp, and which bound a target DNA sequence. In other embodiments, thisDNA fragment can be prepared by PCR amplification of the selectablemarker gene using as primers oligonucleotides that hybridize to the endsof the marker gene and that include the genomic regions that canrecombine with the yeast genome. In embodiments, the linear DNA fragmentcan be efficiently transformed into yeast and recombined into the genomeresulting in gene replacement including with deletion of the target DNAsequence ((as described, for example, in Methods in Enzymology, Volume194, Guide to Yeast Genetics and Molecular and Cell Biology (Part A,2004, Christine Guthrie and Gerald R. Fink (Eds.), Elsevier AcademicPress, San Diego, Calif.)).

Moreover, promoter replacement methods can be used to exchange theendogenous transcriptional control elements allowing another means tomodulate expression such as described in Mnaimneh et al. ((2004) Cell118(1):31-44).

In other embodiments, the PDC target gene encoded activity can bedisrupted using random mutagenesis, which can then be followed byscreening to identify strains with dependency on carbon substrates forgrowth. In this type of method, the DNA sequence of the target geneencoding region, or any other region of the genome affecting carbonsubstrate dependency for growth, need not be known. In embodiments, ascreen for cells with reduced PDC activity and/or two-carbon substratedependency, or other mutants having reduced PDC activity and a reducedor eliminated dependency for exogenous two-carbon substrate for growth,can be useful as recombinant host cells of the invention.

Methods for creating genetic mutations are common and well known in theart and can be applied to the exercise of creating mutants. Commonlyused random genetic modification methods (reviewed in Methods in YeastGenetics, 2005, Cold Spring Harbor Laboratory Press, Cold Spring Harbor,N.Y.) include spontaneous mutagenesis, mutagenesis caused by mutatorgenes, chemical mutagenesis, irradiation with UV or X-rays, ortransposon mutagenesis.

Chemical mutagenesis of host cells can involve, but is not limited to,treatment with one of the following DNA mutagens: ethyl methanesulfonate(EMS), nitrous acid, diethyl sulfate, orN-methyl-N′-nitro-N-nitroso-guanidine (MNNG). Such methods ofmutagenesis have been reviewed in Spencer et al. (Mutagenesis in Yeast,1996, Yeast Protocols: Methods in Cell and Molecular Biology. HumanaPress, Totowa, N.J.). In embodiments, chemical mutagenesis with EMS canbe performed as described in Methods in Yeast Genetics, 2005, ColdSpring Harbor Laboratory Press, Cold Spring Harbor, N.Y. Irradiationwith ultraviolet (UV) light or X-rays can also be used to produce randommutagenesis in yeast cells. The primary effect of mutagenesis by UVirradiation is the formation of pyrimidine dimers which disrupt thefidelity of DNA replication. Protocols for UV-mutagenesis of yeast canbe found in Spencer et al. (Mutagenesis in Yeast, 1996, Yeast Protocols:Methods in Cell and Molecular Biology. Humana Press, Totowa, N.J.). Inembodiments, the introduction of a mutator phenotype can also be used togenerate random chromosomal mutations in host cells. In embodiments,common mutator phenotypes can be obtained through disruption of one ormore of the following genes: PMS1, MAG1, RAD18 or RAD51. In otherembodiments, restoration of the non-mutator phenotype can be obtained byinsertion of the wildtype allele. In other embodiments, collections ofmodified cells produced from any of these or other known randommutagenesis processes may be screened for reduced or eliminated PDCactivity.

Genomes have been completely sequenced and annotated and are publiclyavailable for the following yeast strains: Ashbya gossypii ATCC 10895,Candida glabrata CBS138, Kluyveromyces lactis NRRL Y-1140, Pichiastipitis CBS 6054, Saccharomyces cerevisiae S288c, Schizosaccharomycespombe 972h−, and Yarrowia lipolytica CLIB122. Typically BLAST (describedabove) searching of publicly available databases with known PDCpolynucleotide or polypeptide sequences, such as those provided herein,is used to identify PDC-encoding sequences of other host cells, such asyeast cells.

Accordingly, it is within the scope of the invention to provide pyruvatedecarboxylase polynucleotides and polypeptides having at least about 70%to about 75%, about 75% to about 80%, about 80% to about 85%, about 85%to about 90%, about 90% to about 95%, about 96%, about 97%, about 98%,or about 99% sequence identity to any of the PDC polypeptides orpolypeptides disclosed herein (SEQ ID NOs: 1-20). Identities are basedon the Clustal W method of alignment using the default parameters of GAPPENALTY=10, GAP LENGTH PENALTY=0.1, and Gonnet 250 series of proteinweight matrix.

The modification of PDC in the host cells disclosed herein to reduce oreliminate PDC activity can be confirmed using methods known in the art.For example, PCR methods well known in the art can be used to confirmdeletion of PDC. Other suitable methods will be known to those of skillin the art and include, but are not limited to, lack of growth on yeastextract peptone-dextrose medium (YPD).

Introduction of the Phosphoketolase Pathway

Applicants have found that expression of enzymes associated with thephosphoketolase pathway (e.g., phosphoketolase and/orphosphotransacetylase) results in a reduced or eliminated requirementfor exogenous two-carbon substrate supplementation for growth of PDC-KOcells. Phosphoketolases and/or phosphotransacetylases identified asdescribed herein, can be expressed in such cells using methods describedherein.

Enzymes of the phosphoketolase pathway include phosphoketolase andphosphotransacetylase (FIG. 1). Phosphoketolase (Enzyme CommissionNumber EC 4.1.2.9) catalyzes the conversion of xylulose 5-phosphate intoglyceraldehyde 3-phosphate and acetyl-phosphate (Heath et al., J. Biol.Chem. 231: 1009-29; 1958). Phosphoketolase activity has been identifiedin several yeast strains growing with xylose as the sole carbon sourcebut not in yeast strains grown with glucose (Evans and Ratledge, Arch.Microbiol. 139: 48-52; 1984). Inhibitors of phosphoketolase include, butare not limited to, erythrose 4-phosphate and glyceraldehyde3-phosphate. Phosphotransacetylase (Enzyme Commission Number EC 2.3.1.8)converts acetyl-phosphate into acetyl-CoA.

In embodiments, the phosphoketolase pathway is activated in therecombinant host cells disclosed herein by engineering the cells toexpress polynucleotides and/or polypeptides encoding phosphoketolaseand, optionally, phosphotransacetylase. In embodiments, the recombinanthost cells disclosed herein comprise a heterologous polynucleotideencoding a polypeptide having phosphoketolase activity. In otherembodiments, the recombinant host cells disclosed herein comprise aheterologous polynucleotide encoding a polypeptide havingphosphoketolase activity and a heterologous polynucleotide encoding apolypeptide having phosphotransacetylase activity. In other embodiments,the heterologous polynucleotide encoding a polypeptide havingphosphoketolase activity is overexpressed, or expressed at a level thatis higher than endogenous expression of the same or related endogenousgene, if any. In still other embodiments, the heterologouspolynucleotide encoding a polypeptide having phosphotransacetylaseactivity is overexpressed, or expressed at a level that is higher thanendogenous expression of the same or related endogenous gene, if any.

In embodiments, a polypeptide having phosphoketolase activity catalyzesthe conversion of xylulose 5-phosphate into glyceraldehyde-3-phosphateand acetyl-phosphate and/or the conversion of fructose-6-phosphate intoerythrose-4-phosphate and acetyl-phosphate. In embodiments, the activityof a polypeptide having phosphoketolase activity is inhibited byerythrose 4-phosphate and/or glyceraldehyde 3-phosphate. In otherembodiments, a polypeptide having phosphotransacetylase activitycatalyzes the conversion of acetyl-phosphate into acetyl-CoA.

Numerous examples of polynucleotides, genes and polypeptides encodingphosphoketolase activity are known in the art and can be used in therecombinant host cells disclosed herein. In embodiments, such apolynucleotide, gene and/or polypeptide can be the xylulose5-phosphateketolase (XpkA) of Lactobacillus pentosus MD363 (Posthuma etal., Appl. Environ. Microbiol. 68: 831-7; 2002). XpkA is the centralenzyme of the phosphoketolase pathway (PKP) in lactic acid bacteria, andexhibits a specific activity of 4.455 μmol/min/mg (Posthuma et al.,Appl. Environ. Microbiol. 68: 831-7; 2002). In other embodiments, such apolynucleotide, gene and/or polypeptide can be the phosphoketolase ofLeuconostoc mesenteroides which exhibits a specific activity of 9.9μmol/min/mg and is stable at pH above 4.5 (Goldberg et al., MethodsEnzymol. 9: 515-520; 1966). This phosphoketolase exhibits a Km of 4.7 mMfor D-xylulose 5-phosphate and a Km of 29 mM for fructose 6-phosphate(Goldberg et al., Methods Enzymol. 9: 515-520; 1966). In otherembodiments, such a polynucleotide, gene and/or polypeptide can be theD-xylulose 5-phosphate/D-fructose 6-phosphate phosphoketolase gene xfpfrom B. lactis, as described, for example, in a pentose-metabolizing S.cerevisiae strain by Sonderegger et al. (Appl. Environ. Microbiol. 70:2892-7; 2004).

In embodiments, a polynucleotide, gene and/or polypeptide encodingphosphoketolase corresponds to the Enzyme Commission Number EC 4.1.2.9.

In embodiments, host cells comprise a polypeptide having at least about80%, at least about 85%, at least about 90%, or 100% identity to apolypeptide of Table 4 or an active fragment thereof or a polynucleotideencoding such a polypeptide. In other embodiments, a polynucleotide,gene and/or polypeptide encoding phosphoketolase can include, but is notlimited to, a sequence provided in the following tables 4 or 5.

TABLE 4SEQ ID NOs of phosphoketolase target gene coding regions and proteinsSEQ ID SEQ ID NO: NO: Nucleic Amino Description acid acidAmino Acid sequence Xpk1 172 481MTTDYSSPAYLQKVDKYWRAANYLSVGQLYLKDNPLLQRPL phosphoketolase KASDVKVHPIGHWGTIAGQ from NFIYAHLNRVINKYGLKMFYVEGPGHGGQVMVSNSYLDGTYLactobacillus TDIYPEITQDVEGMQKLFK plantarumQFSFPGGVASHAAPETPGSIHEGGELGYSISHGVGAILDNP DEIAAVVVGDGESETGPLATSWQSTKFINPINDGAVLPILNLNGFKISNPTIFGRTSDAK IKEYFESMNWEPIFVEGDDPEKVHPALAKAMDEAVEKIKAIQKHARENNDATLPVWPMIV FRAPKGWTGPKSWDGDKIEGSFRAHQIPIPVDQNDMEHADALVDWLESYQPKELFNEDGS LKDDIKEIIPTGDSRMAANPITNGGVDPKALNLPNFRDYAVDTSKEGANVKQDMIVWSDY LRDVIKKNPDNFRLFGPDETMSNRLYGVFETTNRQWMEDIHPDSDQYEAPAGRVLDAQLS EHQAEGWLEGYVLTGRHGLFASYEAFLRVVDSMLTQHFKWLRKANELDWRKKYPSLNIIA ASTVFQQDHNGYTHQDPGALTHLAEKKPEYIREYLPADANTLLAVGDVIFRSQEKINYVV TSKHPRQQWFSIEEAKQLVDNGLGIIDWASTDQGSEPDIVFAAAGTEPTLETLAAIQLLH DSFPEMKIRFVNVVDILKLRSPEKDPRGLSDAEFDHYFTKDKPVVFAFHGYEDLVRDIFF DRHNHNLYVHGYRENGDITTPFDVRVMNQMDRFDLAKSAIAAQPAMENTGAAFVQSMDNM LAKHNAYIRDAGTDLPEVN DWQWKGLKXpkA 1890 1889 MSTDYSSPAYLQKVDKYWRAANYLSVGQLYLKDNPLLQRPL phosphoketolaseKASDVKVHPIGHWGTIAGQ from NFIYAHLNRVINKYGLKMFYVEGPGHGGQVMVSNSYLDGTYLactobacillus TDIYPEITQDVEGMQKLFK pentosusQFSFPGGVASHAAPETPGSIHEGGELGYSISHGVGAILDNP MD363 DEIAAVVVGDGESETGPLATSWQSTKFINPINDGAVLPILNLNGFKISNPTIFGRTSDEK IKQYFESMNWEPIFVEGDDPEKVHPALAKAMDEAVEKIKAIQKNARENDDATLPVWPMIV FRAPKGWTGPKSWDGDKIEGSFRAHQIPIPVDQTDMEHADALVDWLESYQPKELFNEDGS LKDDIKEIIPTGDARMAANPITNGGVDPKALNLPNFRDYAVDTSKHGANVKQDMIVWSDY LRDVIKKNPDNFRLFGPDETMSNRLYGVFETTNRQWMEDIHPDSDQYEAPAGRVLDAQLS EHQAEGWLEGYVLTGRHGLFASYEAFLRVVDSMLTQHFKWLRKANELDWRKKYPSLNIIA ASTVFQQDHNGYTHQDPGALTHLAEKKPEYIREYLPADANSLLAVGDVIFRSQEKINYVV TSKHPRQQWFSIEEAKQLVDNGLGIIDWASTDQGSEPDIVFAAAGTEPTLETLAAIQLLH DSFPDMKIRFVNVVDILKLRSPEKDPRGLSDAEFDHYFTKDKPVVFAFHGYEDLVRDIFF DRHNHNLHVHGYRENGDITTPFDVRVMNQMDRFDLAKSAIAAQPAMENTGAAFVQDMDNM LAKHNAYIRDAGTDLPEVN DWQWKGLKXpf D-xylulose 79 388 MTNPVIGTPWQKLDRPVSEEAIEGMDKYWRVANYMSIGQIY5-phosphate/D- LRSNPLMKEPFTRDDVKHR fructose 6-LVGHWGTTPGLNFLLAHINRLIADHQQNTVFIMGPGHGGPA phosphate GTAQSYIDGTYTEYYPNITphosphoketolase KDEAGLQKFFRQFSYPGGIPSHFAPETPGSIHEGGELGYAL from B. lactisSHAYGAIMDNPSLFVPCII GDGEAETGPLATGWQSNKLVNPRTDGIVLPILHLNGYKIANPTILARISDEELHDFFRGM GYHPYEFVAGFDNEDHLSIHRRFAELFETIFDEICDIKAAAQTDDMTRPFYPMLIFRTPK GWTCPKFIDGKKTEGSWRAHQVPLASARDTEAHFEVLKGWMESYKPEELFNADGSIKEDV TAFMPKGELRIGANPNANGGRIREDLKLPELDQYEITGVKEYGHGWGQVEAPRSLGAYCR DIIKNNPDSFRVFGPDETASNRLNATYEVTKKQWDNGYLSALVDENMAVTGQVVEQLSEH QCEGFLEAYLLTGRHGIWSSYESFVHVIDSMLNQHAKWLEATVREIPWRKPISSVNLLVS SHVWRQDHNGFSHQDPGVTSVLLNKTFNNDHVTNIYFATDANMLLAIAEKCFKSTNKINA IFAGKQPAATWITLDEARAELEAGAAEWKWASNAKSNDEVQVVLAAAGDVPTQEIMAASD ALNKMGIKFKVVNVVDLIKLQSSKENDEAMSDEDFADLFTADKPVLFAYHSYAQDVRGLI YDRPNHDNFTVVGYKEQGSTTTPFDMVRVNDMDRYALQAKALELIDADKYADKINELNEF RKTAFQFAVDNGYDIPEFTDWVYPDVKVDETSMLSATAATA GDNE

In other embodiments, a polynucleotide, gene and/or polypeptide encodingphosphoketolase can have at least about 70% to about 75%, about 75% toabout 80%, about 80% to about 85%, about 85% to about 90%, about 90% toabout 95%, about 96%, about 97%, about 98%, or about 99% sequenceidentity to that of any one of the sequences of Table 4, wherein thepolynucleotide, gene and/or polypeptide encodes a polypeptide havingphosphoketolase activity.

In other embodiments, a polynucleotide, gene and/or polypeptide encodingphosphoketolase can be used to identify other phosphoketolasepolynucleotide, gene and/or polypeptide sequences or to identifyphosphoketolase homologs in other cells, as described above for PDC.Such phosphoketolase encoding sequences can be identified, for example,in the literature and/or in bioinformatics databases well known to theskilled person. For example, the identification of phosphoketolaseencoding sequences in other cell types using bioinformatics can beaccomplished through BLAST (as described above) searching of publiclyavailable databases with known phosphoketolase encoding DNA andpolypeptide sequences, such as those provided herein. Identities arebased on the Clustal W method of alignment using the default parametersof GAP PENALTY=10, GAP LENGTH PENALTY=0.1, and Gonnet 250 series ofprotein weight matrix.

Additional phosphoketolase target gene coding regions were identifiedusing diversity search, clustering, experimentally verifiedxylulose-5-phosphate/fructose-6-phosphate phosphoketolases and domainarchitecture. Briefly, a BLAST search with the experimentally verifiedsequences with an Evalue cut-off of 0.01 resulted in 595 sequencematches. Clustering with the CD-HIT program at 95% sequence identity and90% length overlap reduced the number to 436. CD-HIT is a program forclustering large protein database at high sequence identity threshold.The program removes redundant sequences and generates a database of onlythe representatives. (Clustering of highly homologous sequences toreduce the size of large protein database, Weizhong Li, LukaszJaroszewski & Adam Godzik Bioinformatics, (2001) 17:282-283)

Xylulose-5-phosphate/fructose-6-phosphate phosphoketolases have threePfam domains: XFP_N; XFP; XFP_C. Although each of these domains may bepresent in several domain architectures, e.g. XFP_N is found in eightarchitectures. The architecture of interest was determined to be XFP_N;XFP; XFP_C. The cumulative length of the three domains is 760 aminoacids.

A structure/function characterization of the phosphoketolases wasperformed using the HMMER software package. The following informationbased on the HMMER software user guide gives some description of the waythat the hmmbuild program prepares a Profile HMM. A Profile HMM iscapable of modeling gapped alignments, e.g. including insertions anddeletions, which lets the software describe a complete conserved domain(rather than just a small ungapped motif). Insertions and deletions aremodeled using insertion (I) states and deletion (D) states. All columnsthat contain more than a certain fraction x of gap characters will beassigned as an insert column. By default, x is set to 0.5. Each matchstate has an I and a D state associated with it. HMMER calls a group ofthree states (M/D/I) at the same consensus position in the alignment a“node”. These states are interconnected with arrows called statetransition probabilities. M and I states are emitters, while D statesare silent. The transitions are arranged so that at each node, eitherthe M state is used (and a residue is aligned and scored) or the D stateis used (and no residue is aligned, resulting in a deletion-gapcharacter, ‘-’). Insertions occur between nodes, and I states have aself-transition, allowing one or more inserted residues to occur betweenconsensus columns.

The scores of residues in a match state (i.e. match state emissionscores), or in an insert state (i.e. insert state emission scores) areproportional to Log_(—)2(p_x)/(null_x). Where p_x is the probability ofan amino acid residue, at a particular position in the alignment,according to the Profile HMM and null_x is the probability according tothe Null model. The Null model is a simple one state probabilistic modelwith pre-calculated set of emission probabilities for each of the 20amino acids derived from the distribution of amino acids in theSWISSPROT release 24. State transition scores are also calculated as logodds parameters and are propotional to Log_(—)2(t_x). Where t_x is theprobability of transiting to an emitter or non-emitter state.

Using a multiple sequence alignment of experimentally verified sequencescontaining the architecture of interest XFP_N; XFP; XFP_C, a profileHidden Markov Model (HMM) was created for representing members of thexylulose-5-phosphate/fructose-6-phosphate phosphoketolases (XPK-XFP). Asstated in the user guide, Profile HMMs are statistical models ofmultiple sequence alignments. They capture position-specific informationabout how conserved each column of the alignment is, and which aminoacid residues are most likely to occur at each position. Thus HMMs havea formal probabilistic basis. Profile HMMs for a large number of proteinfamilies are publicly available in the PFAM database (Janelia FarmResearch Campus, Ashburn, Va.), seeftp://ftp.sanger.ac.uk/pub/databases/Pfam/releases/Pfam24.0/.

Eight xylulose-5-phosphate/fructose-6-phosphate phosphoketolasessequences with experimentally verified function were identified in theBRENDA database:

1. CBF76492.1 from Aspergillus nidulans FGSC A4 (SEQ ID NO: 355)2. AAR98787.1 from Bifidobacterium longum (SEQ ID NO: 379)3. ZP_(—)03646196.1 from Bifidobacterium bifidum NCIMB 41171 (SEQ ID NO:381)4. ZP_(—)02962870.1 from Bifidobacterium animalis subsp. lactis HN019(SEQ ID NO: 388)5. NP_(—)786060.1 from Lactobacillus plantarum WCFS1 (SEQ ID NO: 481)6. ZP_(—)03940142.1 from Lactobacillus brevis subsp. gravesensis ATCC27305 (SEQ ID NO: 486)7. ZP_(—)03073172.1 from Lactobacillus reuteri 100-23 (SEQ ID NO 468)8. YP_(—)818922.1 from Leuconostoc mesenteroides subsp. mesenteroidesATCC 8293 (SEQ ID NO: 504)The BRENDA database is a freely available information system containingbiochemical and molecular information on all classified enzymes as wellas software tools for querying the database and calculating molecularproperties. The database covers information on classification andnomenclature, reaction and specificity, functional parameters,occurrence, enzyme structure and stability, mutants and enzymeengineering, preparation and isolation, the application of enzymes, andligand-related data. (BRENDA, AMENDA and FRENDA the enzyme informationsystem: new content and tools in 2009. Nucleic Acids Res. 2009 January;37 (Database issue):D588-92. Epub 2008 Nov. 4. Chang A, Scheer M, GroteA, Schomburg I, Schomburg D.) The eight sequences were used to build aprofile HMM which is provided herein as Table 6.

To further identify the proteins of interest, the 436 sequences weresearched with four profile HMMs: the generated XPK_XFP_HMM profile HMMprovided in Table 6 as well as the three published profiles for thethree domains XFP_N; XFP; XFP_C (PFAM DATABASE) described in Tables 7,8, and 9, respectively. 309 protein sequences which lengths were between650 amino acids and 900 amino acids, and contained the three domainswere retained.

All 309 sequences are at least 40% identical to an experimentallyverified phosphoketolase, with exception of 12 sequences that are within35% identity distance. However, all 309 sequences have a highlysignificant match to all 4 profile HMMs. The least significant matcheshave Evalues of 7.5E-242, 1.1E-124, 2.1E-49, 7.8E-37 to XFP_XPK HMM,XFP_N, XFP, and XFP_C profile HMMs respectively. The 309 sequences areprovided in Table 5, however, it is understood that anyxylulose-5-phosphate/fructose-6-phosphate phosphoketolase identifiableby the method described may be expressed in host cells as describedherein. Where accession information is given as “complement(NN_NNNNN.N:X. . . Y)”, it should be understood to mean the reverse complement ofnucleotides X to Y of the sequence with Accession number NN_NNNNN.N.Where accession information is given as “join (NNNNNN.N:X . . . Y,NNNNNN.N:Z . . . Q)”, it should be understood to mean the sequenceresulting from joining nucleotides X to Y of NNNNNN.N to nucleotides Zto Q of NNNNNN.N.

TABLE 5 SEQ ID NOs of xylulose-5-phosphate/fructose-6-phosphatephosphoketolase target gene coding regions and proteins. GENBANKNucleotide Nucleic GENBANK Amino Sequence Acid Amino Acid Acid GIAccession SEQ Sequence SEQ Number Information ID NO: Accession No. IDNO: Source Organism 162147402 complement(NC_010125.1: 21 YP_001601863.1330 Gluconacetobacter 1624982 . . . 1627414) diazotrophicus PAl5127512024 complement(NC_009092.1: 22 YP_001093221.1 331 Shewanellaloihica 1256548 . . . 1258914) PV-4 119774052 complement(NC_008700.1: 23YP_926792.1 332 Shewanella 1105589 . . . 1107955) amazonensis SB2B113971300 NC_008321.1: 3541276 . . . 3543642 24 YP_735093.1 333Shewanella sp. MR-4 126173290 complement(NC_009052.1: 25 YP_001049439.1334 Shewanella baltica 1204351 . . . 1206717) OS155 163750647complement(NZ_ABIC01000018.1: 26 ZP_02157884.1 335 Shewanella benthica47875 . . . 50253) KT99 157374325 complement(NC_009831.1: 27YP_001472925.1 336 Shewanella 1410491 . . . 1412857) sediminis HAW- EB3170725643 complement(NC_010506.1: 28 YP_001759669.1 337 Shewanellawoodyi 1624098 . . . 1626464) ATCC 51908 167623058complement(NC_010334.1: 29 YP_001673352.1 338 Shewanella 1364332 . . .1366698) halifaxensis HAW- EB4 91794082 NC_007954.1: 3270590 . . .3272956 30 YP_563733.1 339 Shewanella denitrificans OS217 254498997NZ_ACUL01000224.1: 31 ZP_05111697.1 340 Legionella 8243 . . . 10492drancourtii LLAP12 239607320 join(EQ999973.1: 7995808 . . . 7995885, 32EEQ84307.1 341 Ajellomyces EQ999973.1: 7996059 . . . 7996116,dermatitidis ER-3 EQ999973.1: 7996178 . . . 7996412, EQ999973.1: 7996486. . . 7996638, EQ999973.1: 7996791 . . . 7997016, EQ999973.1: 7997082 .. . 7997548, EQ999973.1: 7997603 . . . 7997705, EQ999973.1: 7997779 . .. 7998604, EQ999973.1: 7998677 . . . 7998717) 261200667 XM_002626688.1:33 XP_002626734.1 342 Ajellomyces 1 . . . 2034 dermatitidis SLH14081154276328 XM_001538959.1: 34 XP_001539009.1 343 Ajellomyces 1 . . . 2421capsulatus NAm1 225555843 join(GG663374.1: 72330 . . . 72492, 35EEH04133.1 344 Ajellomyces GG663374.1: 72695 . . . 72929, capsulatusG186AR GG663374.1: 73005 . . . 73157, GG663374.1: 73216 . . . 74203,GG663374.1: 74274 . . . 75146) 225681974 join(DS544805.1: 2187102 . . .2187264, 36 EEH20258.1 345 Paracoccidioides DS544805.1: 2187353 . . .2187427, brasiliensis Pb03 DS544805.1: 2187521 . . . 2187755,DS544805.1: 2187839 . . . 2187991, DS544805.1: 2188086 . . . 2188395,DS544805.1: 2188462 . . . 2189082, DS544805.1: 2189147 . . . 2189263,DS544805.1: 2189358 . . . 2189973, DS544805.1: 2190044 . . . 2190084)226289140 join(DS572750.1: 3105630 . . . 3105792, 37 EEH44652.1 346Paracoccidioides DS572750.1: 3106049 . . . 3106283, brasiliensis Pb18DS572750.1: 3106367 . . . 3106519, DS572750.1: 3106614 . . . 3106923,DS572750.1: 3107023 . . . 3107610, DS572750.1: 3107675 . . . 3108500,DS572750.1: 3108572 . . . 3108612) 258564014 XM_002582706.1: 38XP_002582752.1 347 Uncinocarpus reesii 1 . . . 2421 1704 240108203join(ACFW01000030.1: 39 EER26377.1 348 Coccidioides 1281918 . . .1282080, posadasii C735 delta ACFW01000030.1: SOWgp 1282133 . . .1282207, ACFW01000030.1: 1282266 . . . 1282500, ACFW01000030.1: 1282551. . . 1282703, ACFW01000030.1: 1282757 . . . 1283066, ACFW01000030.1:1283132 . . . 1283752, ACFW01000030.1: 1283828 . . . 1284653,ACFW01000030.1: 1284726 . . . 1284763) 238838423 join(DS995701.1:2675053 . . . 2675215, 40 EEQ28085.1 349 Microsporum canis DS995701.1:2675278 . . . 2675352, CBS 113480 DS995701.1: 2675424 . . . 2675658,DS995701.1: 2675745 . . . 2675897, DS995701.1: 2675972 . . . 2676281,DS995701.1: 2676341 . . . 2676961, DS995701.1: 2677062 . . . 2677836,DS995701.1: 2677864 . . . 2677933, DS995701.1: 2677998 . . . 2678013)169770631 XM_001819733.1: 41 XP_001819785.1 350 Aspergillus oryzae 1 . .. 2457 RIB40 145232813 XM_001399743.1: 42 XP_001399780.1 351 Aspergillusniger 1 . . . 2421 119491775 XM_001263381.1: 43 XP_001263382.1 352Neosartorya fischeri 1 . . . 2421 NRRL 181 121705634 XM_001271079.1: 44XP_001271080.1 353 Aspergillus clavatus 1 . . . 2421 NRRL 1 115396290XM_001213784.1: 45 XP_001213784.1 354 Aspergillus terreus 1 . . . 2400NIH2624 259482219 join(BN001303.1: 576345 . . . 576507, 46 CBF76492.1355 Aspergillus nidulans BN001303.1: 576696 . . . 576930, FGSC A4BN001303.1: 576981 . . . 577133, BN001303.1: 577185 . . . 577494,BN001303.1: 577544 . . . 578161, BN001303.1: 578210 . . . 579035,BN001303.1: 579091 . . . 579128) 255942289 XM_002561867.1: 47XP_002561913.1 356 Penicillium 1 . . . 2469 chrysogenum Wisconsin54-1255 242784458 XM_002480346.1: 48 XP_002480391.1 357 Talaromyces 69 .. . 2489 stipitatus ATCC 10500 212527714 XM_002143978.1: 49XP_002144014.1 358 Penicillium 139 . . . 2559 marneffei ATCC 1822470999652 XM_749450.1: 1 . . . 2145 50 XP_754543.1 359 Aspergillusfumigatus Af293 154314622 XM_001556585.1: 51 XP_001556635.1 360Botryotinia 1 . . . 2061 fuckeliana B05.10 156053245 XM_001592499.1: 52XP_001592549.1 361 Sclerotinia 1 . . . 2430 sclerotiorum 1980 46124351XM_386729.1: 1 . . . 2418 53 XP_386729.1 362 Gibberella zeae PH-1256733824 complement(join(GG698897.1: 54 EEU47171.1 363 Nectria 220636 .. . 220670, haematococca mpVI GG698897.1: 220723 . . . 221650, 77-13-4GG698897.1: 221704 . . . 222510, GG698897.1: 222576 . . . 222732,GG698897.1: 222783 . . . 223020, GG698897.1: 223072 . . . 223146,GG698897.1: 223199 . . . 223361)) 261354209 join(DS985216.1: 747889 . .. 748126, 55 EEY16637.1 364 Verticillium DS985216.1: 748174 . . .748564, alboatrum VaMs.102 DS985216.1: 748620 . . . 748929, DS985216.1:748985 . . . 749555, DS985216.1: 749607 . . . 749833, DS985216.1: 749946. . . 750572) 85081035 XM_951556.2: 215 . . . 2662 56 XP_956649.1 365Neurospora crassa OR74A 145609083 XM_364271.2: 1 . . . 2442 57XP_364271.2 366 Magnaporthe grisea 70-15 171679277 XM_001904550.1: 58XP_001904585.1 367 Podospora anserine 1 . . . 2316 169859036XM_001836107.1: 59 XP_001836159.1 368 Coprinopsis cinerea 1 . . . 2418okayama7#130 19112755 NM_001021872.1: 60 NP_595963.1 369Schizosaccharomyces 1 . . . 2478 pombe 213405339 XM_002173405.1: 61XP_002173441.1 370 Schizosaccharomyces 1 . . . 2469 japonicus yFS27558267408 XM_570860.1: 39 . . . 2594 62 XP_570860.1 371 Cryptococcusneoformans var. neoformans JEC21 71018661 XM_754468.1: 1 . . . 2682 63XP_759561.1 372 Ustilago maydis 521 254413307 NZ_DS989851.1: 81897 . . .84338 64 ZP_05027078.1 373 Microcoleus chthonoplastes PCC 7420 256377454NC_013093.1: 3941285 . . . 3943633 65 YP_003101114.1 374 Actinosynnemamirum DSM 43827 221195188 NZ_ACFE01000002.1: 66 ZP_03568244.1 375Atopobium rimae 241103 . . . 243577 ATCC 49626 257785020complement(NC_013203.1: 67 YP_003180237.1 376 Atopobium 1365893 . . .1368364) parvulum DSM 20469 227516879 complement(NZ_ACGK01000053.1:213016 . . . 215490) 68 ZP_03946928.1 377 Atopobium vaginae DSM 15829210630184 NZ_ABXJ01000012.1: 69 ZP_03296299.1 378 Collinsella stercoris49466 . . . 51985 DSM 13279 41056825 AY518215.1: 989 . . . 3466 70AAR98787.1 379 Bifidobacterium longum 223467373 NZ_ACCG01000015.1: 71ZP_03618909.1 380 Bifidobacterium 9765 . . . 12350 breve DSM 20213224282874 NZ_ABQP01000009.1: 72 ZP_03646196.1 381 Bifidobacterium 218668. . . 221073 bifidum NCIMB 41171 229817819 complement(NZ_ABYS02000004.1:73 ZP_04448101.1 382 Bifidobacterium 901411 . . . 903888) angulatum DSM20098 212716076 complement(NZ_ABXY01000011.1: 578312 . . . 580789) 74ZP_03324204.1 383 Bifidobacterium catenulatum DSM 16992 41056831AY518218.1: 1430 . . . 3907 75 AAR98790.1 384 Bifidobacterium sp. CFAR172 41056829 AY518217.1: 951 . . . 3428 76 AAR98789.1 385Bifidobacterium pullorum 227507561 NZ_ACGF01000124.1: 77 ZP_03937610.1386 Gardnerella 41655 . . . 44132 vaginalis ATCC 14019 261337317NZ_ABXB03000001.1: 78 ZP_05965201.1 387 Bifidobacterium 154886 . . .157366 gallicum DSM 20093 183601500 complement(NZ_ABOT01000001.1: 194894. . . 197371) 79 ZP_02962870.1 388 Bifidobacterium animalis subsp.lactis HN019 41056827 AY518216.1:988 . . . 3465 80 AAR98788.1 389Bifidobacterium pseudolongum subsp. Globosum 227516469complement(NZ_ACGK01000047.1: 28634 . . . 31102) 81 ZP_03946518.1 390Atopobium vaginae DSM 15829 76556241 AJ509177.1: 1 . . . 2625 82YP_001511171.1 391 Frankia sp. EAN1pec 158318663 NC_009921.1: 8441355 .. . 8443790 83 YP_713678.1 392 Frankia alni ACN14a 111222884complement(NC_008278.1: 84 YP_002778395.1 393 Rhodococcus 3758441 . . .3760909) opacus B4 226360617 complement(NC_012522.1: 85 YP_701466.1 394Rhodococcus jostii 1273076 . . . 1275478) RHA1 111018494complement(NC_008268.1: 86 ZP_04383880.1 395 Rhodococcus 1575800 . . .1578352) erythropolis SK121 229490027 NZ_ACNO01000014.1: 87 YP_947598.1396 Arthrobacter 107516 . . . 109885 aurescens TC1 119962524NC_008711.1: 2018415 . . . 2020796 88 CAD48946.1 397 Propionibacteriumfreudenreichii subsp. Shermanii 28868876 NC_004578.1: 1837381 . . .1839888 89 NP_791495.1 398 Pseudomonas syringae pv. tomato str. DC3000256425339 NC_013132.1: 8027760 . . . 8030123 90 YP_003125992.1 399Chitinophaga pinensis DSM 2588 161075783 EU223897.1: 1 . . . 2430 91ABX56639.1 400 Verrucomicrobiae bacterium V4 218246512complement(NC_011726.1: 92 YP_002371883.1 401 Cyanothece sp. PCC 1758431. . . 1760839) 8801 172055269 NC_010547.1: 390265 . . . 392673 93YP_001806596.1 402 Cyanothece sp. ATCC 51142 126659520complement(NZ_AAXW01000034.1: 5415 . . . 7823) 94 ZP_01730652.1 403Cyanothece sp. CCY0110 258380665 complement(AM990467.1: 95 CAQ48286.1404 Planktothrix 2704 . . . 5112) rubescens NIVA- CYA 98 209527806NZ_ABYK01000067.1: 96 ZP_03276298.1 405 Arthrospira maxima 8063 . . .10480 CS-328 196258744 NZ_ABVE01000007.1: 97 ZP_03157277.1 406Cyanothece sp. PCC 72906 . . . 75314 7822 218440702complement(NC_011729.1: 98 YP_002379031.1 407 Cyanothece sp. PCC 4207741. . . 4210149) 7424 166366228 complement(NC_010296.1: 99 YP_001658501.1408 Microcystis 3156762 . . . 3159182) aeruginosa NIES- 843 119488765NZ_AAVU01000020.1: 100 ZP_01621774.1 409 Lyngbya sp. PCC 110903 . . .113317 8106 17228976 complement(NC_003272.1: 101 NP_485524.1 410 Nostocsp. PCC 1746056 . . . 1748482) 7120 254422632 NZ_DS989904.1: 4613864 . .. 4616290 102 ZP_05036350.1 411 Synechococcus sp. PCC 7335 158333641NC_009925.1: 422232 . . . 424652 103 YP_001514813.1 412 Acaryochlorismarina MBIC11017 254425820 complement(NZ_DS989905.1: 104 ZP_05039537.1413 Synechococcus sp. 71540 . . . 74017) PCC 7335 170695087complement(NZ_ABLD01000020.1: 33972 . . . 36368) 105 ZP_02886235.1 414Burkholderia graminis C4D1M 209515639 complement(NZ_ABYL01000006.1:33232 . . . 35628) 106 ZP_03264503.1 415 Burkholderia sp. H160 87303015NZ_AANO01000008.1: 107 ZP_01085819.1 416 Synechococcus sp. 122233 . . .124656 WH 5701 254431900 complement(NZ_DS990556.1: 108 ZP_05045603.1 417Cyanobium sp. PCC 2146872 . . . 2149313) 7001 88808134NZ_AAOK01000002.1: 109 ZP_01123645.1 418 Synechococcus sp. 342081 . . .344516 WH 7805 148238545 complement(NC_009481.1: 110 YP_001223932.1 419Synechococcus sp. 226771 . . . 229206) WH 7803 87123187NZ_AANP01000001.1: 111 ZP_01079038.1 420 Synechococcus sp. 180603 . . .183032 RS9917 187919971 complement(NC_010676.1: 112 YP_001889002.1 421Burkholderia 1450148 . . . 1452541) phytofirmans PsJN 91778759complement(NC_007952.1: 113 YP_553967.1 422 Burkholderia 1882080 . . .1884473) xenovorans LB400 170690542 NZ_ABLD01000001.1: 114 ZP_02881709.1423 Burkholderia 565487 . . . 567880 graminis C4D1M 209521856NZ_ABYL01000194.1: 115 ZP_03270532.1 424 Burkholderia sp. 6778 . . .9171 H160 186474278 complement(NC_010623.1: 116 YP_001861620.1 425Burkholderia 2647064 . . . 2649448) phymatum STM815 225873826complement(NC_012483.1: 117 YP_002755285.1 426 Acidobacterium 2598033 .. . 2600420) capsulatum ATCC 51196 206602403 DS995260.1: 236338 . . .238704 118 EDZ38884.1 427 Leptospirillum sp. Group II ‘5-way CG’251772639 complement(GG693868.1: 119 EES53204.1 428 Leptospirillum 86578. . . 88956) ferrodiazotrophum 56752022 complement(NC_006576.1: 120YP_172723.1 429 Synechococcus 2156604 . . . 2158994) elongatus PCC 630122298729 complement(NC_004113.1: 121 NP_681976.1 430 Thermosynechococcus1224195 . . . 1226633) elongatus BP-1 53804073 NC_002977.6: 1693459 . .. 1695894 122 YP_114037.1 431 Methylococcus capsulatus str. Bath220907266 NC_011884.1: 1725657 . . . 1728098 123 YP_002482577.1 432Cyanothece sp. PCC 7425 16332268 NC_000911.1: 3500713 . . . 3503178 124NP_442996.1 433 Synechocystis sp. PCC 6803 220907424complement(NC_011884.1: 125 YP_002482735.1 434 Cyanothece sp. PCC1898702 . . . 1901167) 7425 241777601 complement(NZ_ACQQ01000020.1:30393 . . . 32762) 126 ZP_04774866.1 435 Allochromatium vinosum DSM 180114778289 NZ_AATS01000014.1: 127 ZP_01453148.1 436 Mariprofundus 23435 .. . 25801 ferrooxydans PV-1 251827471 complement(NZ_ACSD01000006.1: 128ZP_04830548.1 437 Gallionella 39617 . . . 41986) ferruginea ES-2121712503 XM_001273862.1: 129 XP_001273863.1 438 Aspergillus clavatus 1. . . 2436 NRRL 1 119473535 XM_001258642.1: 130 XP_001258643.1 439Neosartorya fischeri 1 . . . 2439 NRRL 181 169763560 XM_001727628.1: 131XP_001727680.1 440 Aspergillus oryzae 1 . . . 2433 RIB40 145248115XM_001396269.1: 132 XP_001396306.1 441 Aspergillus niger 1 . . . 2448115400974 XM_001216075.1: 133 XP_001216075.1 442 Aspergillus terreus 1 .. . 2457 NIH2624 255952755 XM_002567084.1: 134 XP_002567130.1 443Penicillium 1 . . . 2433 chrysogenum Wisconsin 54-1255 212527388XM_002143815.1: 135 XP_002143851.1 444 Penicillium 98 . . . 2551marneffei ATCC 18224 242783584 XM_002480171.1: 136 XP_002480216.1 445Talaromyces 1 . . . 2448 stipitatus ATCC 10500 154321267 XM_001559899.1:137 XP_001559949.1 446 Botryotinia 1 . . . 2466 fuckeliana B05.10156054348 XM_001593050.1: 138 XP_001593100.1 447 Sclerotinia 1 . . .2499 sclerotiorum 1980 189191706 XM_001932157.1: 139 XP_001932192.1 448Pyrenophora tritici- 1 . . . 2469 repentis Pt-1C-BFP 169600613XM_001793677.1: 140 XP_001793729.1 449 Phaeosphaeria 1 . . . 2466nodorum SN15 58260732 XM_567776.1: 41 . . . 2545 141 XP_567776.1 450Cryptococcus neoformans var. neoformans JEC21 46123901 XM_386504.1: 1 .. . 2460 142 XP_386504.1 451 Gibberella zeae PH-1 256732917complement(join(GG698898.1: 143 EEU46265.1 452 Nectria 321524 . . .322233, haematococca mpVI GG698898.1: 322285 . . . 322489, 77-13-4GG698898.1: 322540 . . . 324081)) 225729111 FJ790496.1: 215 . . . 2677144 ACO24516.1 453 Metarhizium anisopliae 85094948 XM_954892.2: 155 . .. 2638 145 XP_959985.1 454 Neurospora crassa OR74A 171679479XM_001904651.1: 146 XP_001904686.1 455 Podospora anserine 1 . . . 2517198283820 NC_011206.1: 1682860 . . . 1685307 147 YP_002220141.1 456Acidithiobacillus ferrooxidans ATCC 53993 148243889 NC_009468.1: 90683 .. . 93145 148 YP_001220128.1 457 Acidiphilium cryptum JF-5 157364435NC_009828.1: 1658895 . . . 1661258 149 YP_001471202.1 458 Thermotogalettingae TMO 217966781 NC_011661.1: 369050 . . . 371428 150YP_002352287.1 459 Dictyoglomus turgidum DSM 6724 92109503complement(NC_007960.1: 151 YP_571790.1 460 Nitrobacter 14429 . . .16810) hamburgensis X14 87310270 complement(NZ_AANZ01000017.1: 80191 . .. 82560) 152 ZP_01092401.1 461 Blastopirellula marina DSM 3645 152995974NC_009654.1: 2214232 . . . 2216625 153 YP_001340809.1 462 Marinomonassp. MWYL1 32473390 NC_005027.1: 2520925 . . . 2523306 154 NP_866384.1463 Rhodopirellula baltica SH 1 254495580 complement(NZ_ACUL01000002.1:21176 . . . 23557) 155 ZP_05108502.1 464 Legionella drancourtii LLAP12254380451 NZ_DS570384.1: 88623 . . . 90992 156 ZP_04995817.1 465Streptomyces sp. Mg1 227974767 NZ_ACGW01000133.1: 157 ZP_04023055.1 466Lactobacillus reuteri 1172 . . . 3235 SD2112 227530011NZ_ACGV01000134.1: 158 ZP_03960060.1 467 Lactobacillus 2320 . . . 4794vaginalis ATCC 49540 194467185 complement(NZ_AAPZ02000001.1: 159ZP_03073172.1 468 Lactobacillus reuteri 905298 . . . 907709) 100-23256847586 NZ_GG698803.1: 21616 . . . 24015 160 ZP_05553031.1 469Lactobacillus coleohominis 101-4- CHN 260662452complement(NZ_GG704700.1: 161 ZP_05863347.1 470 Lactobacillus 145244 . .. 147643) fermentum 28-3- CHN 227903484 NZ_ACHN01000046.1: 162ZP_04021289.1 471 Lactobacillus 59035 . . . 61452 acidophilus ATCC 4796227877116 NZ_ACKR01000020.1: 163 ZP_03995194.1 472 Lactobacillus 11753 .. . 14191 crispatus JV-V01 227893117 NZ_ACGU01000035.1: 164ZP_04010922.1 473 Lactobacillus 36787 . . . 39186 ultunensis DSM 16047256844475 NZ_GG698762.1: 280846 . . . 283242 165 ZP_05549961.1 474Lactobacillus crispatus 125-2- CHN 227521312complement(NZ_ACG001000008.1: 37191 . . . 39647) 166 ZP_03951361.1 475Lactobacillus gasseri JV-V03 259501613 complement(NZ_ACLN01000019.1:10173 . . . 12569) 167 ZP_05744515.1 476 Lactobacillus iners DSM 13335104773655 NC_008054.1: 449229 . . . 451631 168 YP_618635.1 477Lactobacillus delbrueckii subsp. bulgaricus ATCC 11842 227525868NZ_ACGQ01000037.1: 169 ZP_03955917.1 478 Lactobacillus 36941 . . . 39310jensenii JV-V16 227512366 NZ_ACGH01000107.1: 170 ZP_03942415.1 479Lactobacillus 31655 . . . 34045 buchneri ATCC 11577 118587374complement(NZ_AAUV01000059.1: 59008 . . . 61416) 171 ZP_01544800.1 480Oenococcus oeni ATCC BAA-1163 28379168 complement(NC_004567.1: 172NP_786060.1 481 Lactobacillus 2362936 . . . 2365302) plantarum WCFS121363093 AJ309011.1: 181 . . . 2547 173 Q937F6 482 XPKA_LACPE 81427904NC_007576.1: 286496 . . . 288859 174 YP_394903.1 483 Lactobacillus sakeisubsp. sakei 23K 116492156 NC_008525.1: 398927 . . . 401290 175YP_803891.1 484 Pediococcus pentosaceus ATCC 25745 259648565 AP011548.1:211570 . . . 213957 176 BAI40727.1 485 Lactobacillus rhamnosus GG227510093 complement(NZ_ACGG01000115.1: 64541 . . . 66952) 177ZP_03940142.1 486 Lactobacillus brevis subsp. gravesensis ATCC 27305227891468 complement(NZ_ACGT01000007.1: 44265 . . . 46625) 178ZP_04009273.1 487 Lactobacillus salivarius ATCC 11741 227528594NZ_ACGS01000122.1: 179 ZP_03958643.1 488 Lactobacillus 352 . . . 2721ruminis ATCC 25644 229542373 complement(NZ_AAWV02000001.1: 1384102 . . .1386486) 180 ZP_04431433.1 489 Bacillus coagulans 36D1 238021480complement(NZ_ACJW02000002.1: 913355 . . . 915730) 181 ZP_04601906.1 490Kingella oralis ATCC 51147 259046526 NZ_ACKZ01000008.1: 182ZP_05736927.1 491 Granulicatella 36586 . . . 38955 adiacens ATCC 49175157150221 NC_009785.1: 333239 . . . 335623 183 YP_001449631.1 492Streptococcus gordonii str. Challis substr. CH1 25011879complement(NC_004368.1: 184 NP_736274.1 493 Streptococcus 1900754 . . .1903132) agalactiae NEM316 229555065 complement(NZ_ACCR01000006.1: 74043. . . 76418) 185 ZP_04442854.1 494 Listeria grayi DSM 20601 257866707NZ_GG670386.1: 478278 . . . 480644 186 ZP_05646360.1 495 Enterococcuscasseliflavus EC30 257870669 NZ_GG670289.1: 233512 . . . 235875 187ZP_05650322.1 496 Enterococcus gallinarum EG2 257895654 NZ_GG670306.1:612981 . . . 615353 188 ZP_05675307.1 497 Enterococcus faecium Com12238810139 AP009608.1: 744956 . . . 747334 189 BAH69929.1 498 Mycoplasmafermentans PG18 193216764 NC_011025.1: 384420 . . . 386801 190YP_002000006.1 499 Mycoplasma arthritidis 158L3-1 148377390 NC_009497.1:136795 . . . 139182 191 YP_001256266.1 500 Mycoplasma agalactiae PG2191639669 NC_010999.1: 2885324 . . . 2887711 192 YP_001988835.1 501Lactobacillus casei BL23 28379861 NC_004567.1: 3169067 . . . 3171478 193NP_786753.1 502 Lactobacillus plantarum WCFS1 227892171complement(NZ_ACGT01000037.1: 21330 . . . 23759) 194 ZP_04009976.1 503Lactobacillus salivarius ATCC 11741 116618551 NC_008531.1: 1449343 . . .1451709 195 YP_818922.1 504 Leuconostoc mesenteroides subsp.mesenteroides ATCC 8293 116333142 NC_008497.1: 507704 . . . 510163 196YP_794669.1 505 Lactobacillus brevis ATCC 367 241895257complement(NZ_ACKU01000007.1: 101374 . . . 103833) 197 ZP_04782553.1 506Weissella paramesenteroides ATCC 33313 170016535 NC_010471.1: 181964 . .. 184417 198 YP_001727454.1 507 Leuconostoc citreum KM20 116619034complement(NC_008531.1: 199 YP_819405.1 508 Leuconostoc 1934181 . . .1936622) mesenteroides subsp. mesenteroides ATCC 8293 161702316EU255918.1: 18411 . . . 20879 200 ABX75772.1 509 Lactococcus lactissubsp. Lactis 116491770 complement(NC_008528.1: 201 YP_811314.1 510Oenococcus oeni 1731509 . . . 1733962) PSU-1 182419955complement(NZ_ABDT01000107.2: 13616 . . . 15991) 202 ZP_02951191.1 511Clostridium butyricum 5521 255523324 complement(NZ_ACVI01000003.1: 203ZP_05390294.1 512 Clostridium 55354 . . . 57747) carboxidivorans P715894622 NC_003030.1: 1482782 . . . 1485172 204 NP_347971.1 513Clostridium acetobutylicum ATCC 824 226324778complement(NZ_ABVR01000041.1: 500857 . . . 503232) 205 ZP_03800296.1 514Coprococcus comes ATCC 27758 253580358 NZ_GG696051.1: 158015 . . .160390 206 ZP_04857624.1 515 Ruminococcus sp. 5_1_39B_FAA 257413435NZ_ABYJ02000055.1: 207 ZP_04743029.2 516 Roseburia 10320 . . . 12779intestinalis L1-82 154500233 complement(NZ_AAXG02000041.1: 208ZP_02038271.1 517 Bacteroides 34174 . . . 36609) capillosus ATCC 29799219119570 XM_002180506.1: 209 XP_002180542.1 518 Phaeodactylum 1 . . .2508 tricornutum CCAP 1055/1 91975971 NC_007958.1: 1660408 . . . 1662762210 YP_568630.1 519 Rhodopseudomonas palustris BisB5 86750966complement(NC_007778.1: 211 YP_487462.1 520 Rhodopseudomonas 4411322 . .. 4413676) palustris HaA2 39934743 NC_005296.1: 1858439 . . . 1860790212 NP_947019.1 521 Rhodopseudomonas palustris CGA009 90425290complement(NC_007925.1: 213 YP_533660.1 522 Rhodopseudomonas 4235875 . .. 4238229) palustris BisB18 121583071 NC_008758.1: 65532 . . . 67904 214YP_973512.1 523 Polaromonas naphthalenivorans CJ2 115376972complement(NZ_AAMD01000095.1: 4173 . . . 6533) 215 ZP_01464191.1 524Stigmatella aurantiaca DW4/3-1 148547676 complement(NC_009512.1: 216YP_001267778.1 525 Pseudomonas putida 2807645 . . . 2810020) F1116668711 NC_008541.1: 145493 . . . 147928 217 YP_829644.1 526Arthrobacter sp. FB24 220911083 NC_011886.1: 321712 . . . 324174 218YP_002486392.1 527 Arthrobacter chlorophenolicus A6 260517200complement(NZ_ABUN01000002.1: 92936 . . . 95461) 219 ZP_05816651.1 528Sanguibacter keddieii DSM 10542 229821527 NC_012669.1: 3398743 . . .3401217 220 YP_002883053.1 529 Beutenbergia cavernae DSM 12333 256832813NC_013174.1: 1712156 . . . 1714588 221 YP_003161540.1 530 Jonesiadenitrificans DSM 20603 227428425 complement(NZ_ABVC01000008.1: 152502 .. . 154988) 222 ZP_03911482.1 531 Xylanimonas cellulosilytica DSM 15894165929357 AM182260.1: 1 . . . 2481 223 CAJ57850.1 532 Cellulomonasflavigena 145223927 NC_009338.1: 3525804 . . . 3528275 224YP_001134605.1 533 Mycobacterium gilvum PYR-GCK 120404048 NC_008726.1:3236585 . . . 3239083 225 YP_953877.1 534 Mycobacterium vanbaaleniiPYR-1 257069356 NC_013172.1: 2493744 . . . 2496215 226 YP_003155611.1535 Brachybacterium faecium DSM 4810 256824167 NC_013169.1: 273585 . . .276047 227 YP_003148127.1 536 Kytococcus sedentarius DSM 20547 148271607NC_009480.1: 506602 . . . 509040 228 YP_001221168.1 537 Clavibactermichiganensis subsp. michiganensis NCPPB 382 145594129complement(NC_009380.1: 229 YP_001158426.1 538 Salinispora tropica1798516 . . . 1800918) CNB-440 159037167 complement(NC_009953.1: 230YP_001536420.1 539 Salinispora 1767167 . . . 1769569) arenicola CNS-205238063593 complement(NZ_GG657738.1: 231 ZP_04608302.1 540 Micromonosporasp. 5405062 . . . 5407251) ATCC 39149 118469963 NC_008596.1: 3674267 . .. 3676639 232 YP_887914.1 541 Mycobacterium smegmatis str. MC2 155108799759 NC_008146.1: 2939527 . . . 2941947 233 YP_639956.1 542Mycobacterium sp. MCS 240170498 complement(NZ_ACBV01000039.1: 21 . . .2423) 234 ZP_04749157.1 543 Mycobacterium kansasii ATCC 12478 183982748complement(NC_010612.1: 235 YP_001851039.1 544 Mycobacterium 3341817 . .. 3344219) marinum M 41407671 complement(NC_002944.2: 236 NP_960507.1545 Mycobacterium 1726717 . . . 1729131) avium subsp. paratuberculosisK- 10 254819329 NZ_ABIN01000047.1: 237 ZP_05224330.1 546 Mycobacterium36474 . . . 38837 intracellulare ATCC 13950 169629591complement(NC_010397.1: 238 YP_001703240.1 547 Mycobacterium 2559451 . .. 2561871) abscessus 84496279 complement(NZ_AAMN01000002.1: 433314 . . .435707) 239 ZP_00995133.1 548 Janibacter sp. HTCC2649 72163369NC_007333.1: 3478272 . . . 3480650 240 YP_291026.1 549 Thermobifidafusca YX 227984600 complement(NZ_ABUZ01000013.1: 70531 . . . 72909) 241ZP_04031845.1 550 Thermomonospora curvata DSM 43183 229855558complement(NZ_ABUU01000106.1: 1385 . . . 3700) 242 ZP_04475514.1 551Streptosporangium roseum DSM 43021 229209207 NZ_ABUI01000028.1: 243ZP_04335641.1 552 Nocardiopsis 55841 . . . 58189 dassonvillei subsp.dassonvillei DSM 43111 229862587 NZ_ABUS01000001.1: 244 ZP_04482201.1553 Stackebrandtia 1911934 . . . 1914330 nassauensis DSM 44728 256376052NC_013093.1: 2125566 . . . 2127935 245 YP_003099712.1 554 Actinosynnemamirum DSM 43827 32141117 complement(NC_003888.3: 246 NP_733508.1 555Streptomyces 656319 . . . 658772) coelicolor A3(2) 117164830complement(AM238664.1: 247 CAJ88379.1 556 Streptomyces 846551 . . .849055) ambofaciens ATCC 23877 256811868 complement(NZ_ACFA01000015.1:248 ZP_05536883.1 557 Streptomyces 3377 . . . 5761) griseoflavus Tu4000254405496 complement(NZ_DS570938.1: 249 ZP_05020421.1 558 Streptomyces43288 . . . 45726) sviceus ATCC 29083 260644540 complement(FN554889.1:250 CBG67625.1 559 Streptomyces 480316 . . . 482694) scabiei 87.2229827814 complement(NC_003155.4: 251 NP_822448.1 560 Streptomyces1579336 . . . 1581717) avermitilis MA- 4680 239932594 NZ_ABYA01000503.1:252 ZP_04689547.1 561 Streptomyces 5217 . . . 7595 ghanaensis ATCC 14672256800397 complement(NZ_ACEZ01000048.1: 253 ZP_05530021.1 562Streptomyces 24916 . . . 27303) viridochromogenes DSM 40736 256774038complement(NZ_ACEX01000074.1: 46221 . . . 48614) 254 ZP_05512501.1 563Streptomyces hygroscopicus ATCC 53653 260452518 NZ_ACZH01000001.1: 255ZP_05800927.1 564 Streptomyces 321972 . . . 324359 flavogriseus ATCC33331 182440556 NC_010572.1: 8084439 . . . 8086826 256 YP_001828275.1565 Streptomyces griseus subsp. griseus NBRC 13350 239982969NZ_ABYC01000425.1: 257 ZP_04705493.1 566 Streptomyces albus 13265 . . .15646 J1074 254381599 NZ_DS570386.1: 118817 . . . 121204 258ZP_04996963.1 567 Streptomyces sp. Mg1 256674998 NZ_ACEU01000020.1: 259ZP_05485309.1 568 Streptomyces sp. 1507 . . . 3900 SPB78 227377421NZ_ABUC01000002.1: 260 ZP_03860882.1 569 Kribbella flavida 229225 . . .231603 DSM 17836 54023297 complement(NC_006361.1: 261 YP_117539.1 570Nocardia farcinica 1487629 . . . 1490097) IFM 10152 158313048NC_009921.1: 1426213 . . . 1428621 262 YP_001505556.1 571 Frankia sp.EAN1pec 86742227 complement(NC_007777.1: 263 YP_482627.1 572 Frankia sp.CcI3 4238578 . . . 4240986) 256395329 NC_013131.1: 7133131 . . . 7135533264 YP_003116893.1 573 Catenulispora acidiphila DSM 44928 117927729NC_008578.1: 555555 . . . 557948 265 YP_872280.1 574 Acidothermuscellulolyticus 11B 119717842 complement(NC_008699.1: 266 YP_924807.1 575Nocardioides sp. 3839565 . . . 3841961) JS614 134098496 NC_009142.1:2098116 . . . 2100512 267 YP_001104157.1 576 Saccharopolyspora erythraeaNRRL 2338 209550756 NC_011369.1: 3264963 . . . 3267347 268YP_002282673.1 577 Rhizobium leguminosarum bv. trifolii WSM2304241206160 NC_012850.1: 3503904 . . . 3506288 269 YP_002977256.1 578Rhizobium leguminosarum bv. trifolii WSM1325 190893254 NC_010994.1:3714233 . . . 3716620 270 YP_001979796.1 579 Rhizobium etli CIAT 65286359034 NC_007761.1: 3623921 . . . 3626308 271 YP_470926.1 580Rhizobium etli CFN 42 222081270 complement(NC_011983.1: 272YP_002540633.1 581 Agrobacterium 490969 . . . 493383) radiobacter K84254720555 NZ_ACBQ01000064.1: 273 ZP_05182366.1 582 Brucella sp. 83/13129340 . . . 131718 239835057 complement(NZ_ACQA01000003.1: 10528 . . .13017) 274 ZP_04683384.1 583 Ochrobactrum intermedium LMG 3301 153012043NC_009671.1: 16319 . . . 18706 275 YP_001373254.1 584 Ochrobactrumanthropi ATCC 49188 146339061 complement(NC_009445.1: 276 YP_001204109.1585 Bradyrhizobium sp. 2141749 . . . 2144226) ORS278 148253833complement(NC_009485.1: 277 YP_001238418.1 586 Bradyrhizobium sp.2424642 . . . 2427059) BTAi1 27377629 complement(NC_004463.1: 278NP_769158.1 587 Bradyrhizobium 2749734 . . . 2752139) japonicum USDA 11092117435 complement(NC_007964.1: 279 YP_577164.1 588 Nitrobacter 2109162. . . 2111570) hamburgensis X14 240137143 NC_012808.1: 407982 . . .410417 280 YP_002961612.1 589 Methylobacterium extorquens AM1 110634584complement(NC_008254.1: 281 YP_674792.1 590 Mesorhizobium sp. 2388345 .. . 2390747) BNC1 260467447 NZ_ACZA01000051.1: 282 ZP_05813617.1 591Mesorhizobium 15952 . . . 18360 opportunistum WSM2075 75676138NC_007406.1: 2135469 . . . 2137856 283 YP_318559.1 592 Nitrobacterwinogradskyi Nb- 255 170749020 complement(NC_010505.1: 284YP_001755280.1 593 Methylobacterium 2769888 . . . 2772470) radiotoleransJCM 2831 170746859 complement(NC_010505.1: 285 YP_001753119.1 594Methylobacterium 465997 . . . 468552) radiotolerans JCM 2831 254558916NC_012988.1: 271224 . . . 273809 286 YP_003066011.1 595 Methylobacteriumextorquens DM4 240140298 NC_012808.1: 3931130 . . . 3933676 287YP_002964777.1 596 Methylobacterium extorquens AM1 220925990NC_011894.1: 6291823 . . . 6294321 288 YP_002501292.1 597Methylobacterium nodulans ORS 2060 220919962 complement(NC_011892.1: 289YP_002495265.1 598 Methylobacterium 451339 . . . 453840) nodulans ORS2060 170741732 NC_010511.1: 3988668 . . . 3991166 290 YP_001770387.1 599Methylobacterium sp. 4-46 239815802 complement(NC_012791.1: 291YP_002944712.1 600 Variovorax 2971257 . . . 2973608) paradoxus S11089069402 NZ_AAOT01000017.1: 292 ZP_01156757.1 601 Oceanicola 31124 . . .33460 granulosus HTCC2516 119509641 complement(NZ_AAVW01000007.1: 15878. . . 18259) 293 ZP_01628787.1 602 Nodularia spumigena CCY9414 186682350NC_010628.1: 2389837 . . . 2392218 294 YP_001865546.1 603 Nostocpunctiforme PCC 73102 75906719 complement(NC_007413.1: 295 YP_321015.1604 Anabaena variabilis 617971 . . . 620352) ATCC 29413 225522346NZ_ACIR01000182.1: 296 ZP_03769140.1 605 Nostoc azollae' 0708 624 . . .2756 37520566 NC_005125.1: 1065716 . . . 1068097 297 NP_923943.1 606Gloeobacter violaceus PCC 7421 86608623 NC_007776.1: 1182311 . . .1184686 298 YP_477385.1 607 Synechococcus sp. JA-2-3B′a(2-13) 150398192complement(NC_009636.1: 299 YP_001328659.1 608 Sinorhizobium 3144485 . .. 3146857) medicae WSM419 116249832 complement(NC_008380.1: 300YP_765670.1 609 Rhizobium 82152 . . . 84617) leguminosarum bv. viciae3841 195970218 complement(NC_003047.1: 301 NP_384212.2 610 Sinorhizobium123688 . . . 126141) meliloti 1021 171912985 NZ_ABIZ01000001.1: 302ZP_02928455.1 611 Verrucomicrobium 4370841 . . . 4373354 spinosum DSM4136 163849496 complement(NC_010172.1: 303 YP_001637539.1 612Methylobacterium 46285 . . . 48720) extorquens PA1 85714839NZ_AAMY01000005.1: 304 ZP_01045825.1 613 Nitrobacter sp. Nb- 72844 . . .75210 311A 168704325 complement(NZ_ABGO01000323.1: 57 . . . 2462) 305ZP_02736602.1 614 Gemmata obscuriglobus UQM 2246 256829143complement(NC_013173.1: 306 YP_003157871.1 615 Desulfomicrobium 1530488. . . 1532881) baculatum DSM 4028 223939426complement(NZ_ABOX02000044.1: 41392 . . . 43863) 307 ZP_03631304.1 616bacterium Ellin514 237747078 complement(NZ_GG658151.1: 308 ZP_04577558.1617 Oxalobacter 2005797 . . . 2008190) formigenes HOxBLS 237749232complement(NZ_GG658170.1: 309 ZP_04579712.1 618 Oxalobacter 2042015 . .. 2044411) formigenes OXCC13 116624013 NC_008536.1: 6218168 . . .6220537 310 YP_826169.1 619 Solibacter usitatus Ellin6076 194336959complement(NC_011060.1: 311 YP_002018753.1 620 Pelodictyon 2004498 . . .2006885) phaeoclathratiforme BU-1 194334425 complement(NC_011059.1: 312YP_002016285.1 621 Prosthecochloris 1762093 . . . 1764489) aestuarii DSM271 189346840 complement(NC_010803.1: 313 YP_001943369.1 622 Chlorobium1427679 . . . 1430054) limicola DSM 245 21674344 complement(NC_002932.3:314 NP_662409.1 623 Chlorobium 1423776 . . . 1426289) tepidum TLS110597897 complement(NZ_AASE01000009.1: 315 ZP_01386179.1 624 Chlorobium37756 . . . 40179) ferrooxidans DSM 13031 78187379complement(NC_007512.1: 316 YP_375422.1 625 Chlorobium 1709621 . . .1712050) luteolum DSM 273 71907690 complement(NC_007298.1: 317YP_285277.1 626 Dechloromonas 2220090 . . . 2222456) aromatica RCB74316849 NC_007404.1: 876540 . . . 878978 318 YP_314589.1 627Thiobacillus denitrificans ATCC 25259 91775246 complement(NC_007947.1:319 YP_545002.1 628 Methylobacillus 935825 . . . 938200) flagellatus KT30250069 NC_004757.1: 2318109 . . . 2320481 320 NP_842139.1 629Nitrosomonas europaea ATCC 19718 114332052 NC_008344.1: 2209596 . . .2211971 321 YP_748274.1 630 Nitrosomonas eutropha C91 82702122NC_007614.1: 1152112 . . . 1154535 322 YP_411688.1 631 Nitrosospiramultiformis ATCC 25196 77166175 NC_007484.1: 3082455 . . . 3084869 323YP_344700.1 632 Nitrosococcus oceani ATCC 19707 46445639complement(NC_005861.1: 324 YP_007004.1 633 Candidatus 5907 . . . 8303)Protochlamydia amoebophila UWE25 16263040 complement(NC_003037.1: 325NP_435833.1 634 Sinorhizobium 591065 . . . 593440) meliloti 1021229532493 NZ_ABUV01000006.1: 326 ZP_04421874.1 635 Sulfurospirillum47234 . . . 49585 deleyianum DSM 6946 13475490 NC_002678.2: 5384229 . .. 5386652 327 NP_107054.1 636 Mesorhizobium loti MAFF303099 209885940complement(NC_011386.1: 328 YP_002289797.1 637 Oligotropha 2786353 . . .2788746) carboxidovorans OM5 182679166 NC_010581.1: 2524033 . . .2526420 329 YP_001833312.1 638 Beijerinckia indica subsp. indica ATCC9039

Numerous examples of polynucleotides, genes and/or polypeptides encodingphosphotransacetylase are known in the art and can be used in relationto the recombinant host cells disclosed herein. In embodiments, thephosphotransacetylase can be EutD from Lactobacillus plantarum. Inembodiments, the phosphotransacetylase can be the phosphotransacetylasefrom Bacillus subtilis. This phosphotransacetylase has a specificactivity of 1371 μmol/min/mg and a Km 0.06 mM for acetyl-CoA (Rado andHoch, Biochim. Biophys. Acta. 321: 114-25; 1973). In addition, theequilibrium constant (Keq) of this reaction was found to be 154±14 infavor of the formation of acetyl-CoA according to the following formula:

$\frac{\left\lbrack {{acetyl}\text{-}{CoA}} \right\rbrack \lbrack{Pi}\rbrack}{\lbrack{CoA}\rbrack \left\lbrack {{acetyl}\text{-}P} \right\rbrack} = {Keq}$

In embodiments, host cells comprise a polypeptide having at least about80%, at least about 85%, at least about 90%, or at least about 99%identity to a polypeptide of Table 10 or an active fragment thereof or apolynucleotide encoding such a polypeptide. In embodiments, thephosphotransacetylase can be a polypeptide having at least about 80%, atleast about 85%, at least about 90%, at least about 95%, or at leastabout 99% identity to SEQ ID NO: 1472 or an active fragment thereof. Inother embodiments, a polynucleotide, gene and/or polypeptide encodingphosphotransacetylase can include, but is not limited to, a sequenceprovided in the following tables 10 or 12.

TABLE 10SEQ ID NOs of phosphotransacetylase target gene coding regions and proteins.SEQ ID SEQ ID  NO: NO: Nucleic Amino Description acid acidAmino acid sequence EutD 1111 1472MDLFESLAQKITGKDQTIVFPEGTEPRIVGAAARLAADGLVKPIVLGATDKVQAVANDLNphosphotransacetylaseADLTGVQVLDPATYPAEDKQAMLDALVERRKGKNTPEQAAKMLEDENYFGTMLVYMGKADfrom LactobacillusGMVSGAIHPTGDTVRPALQIIKTKPGSHRISGAFIMQKGEERYVFADCAINIDPDADTLA plantarumEIATQSAATAKVFDIDPKVAMLSFSTKGSAKGEMVTKVQEATAKAQAAEPELAIDGELQFDAAFVEKVGLQKAPGSKVAGHANVFVFPELQSGNIGYKIAQRFGHFEAVGPVLQGLNKPVSDLSRGCSEEDVYKVAIITAAQGLA Phosphotransacetylase 1061 1422MADLFSTVQEKVAGKDVKIVFPEGLDERILEAVSKLAGNKVLNPIVIGNENEIQAKAKELfrom Bacillus subtilisNLTLGGVKIYDPHTYEGMEDLVQAFVERRKGKATEEQARKALLDENYFGTMLVYKGLADGLVSGAAHSTADTVRPALQIIKTKEGVKKTSGVFIMARGEEQYVFADCAINIAPDSQDLAEIAIESANTAKMFDIEPRVAMLSFSTKGSAKSDETEKVADAVKIAKEKAPELTLDGEFQFDAAFVPSVAEKKAPDSEIKGDANVFVFPSLEAGNIGYKIAQRLGNFEAVGPILQGLNMPVNDLSRGCNAEDVYNLALITAAQAL

Additional suitable phosphotransacetylase target gene coding regions andproteins were identified by diversity searching and clustering. A blastsearch of the non redundant GenBank protein database (NR) was performedwith the L. plantarum EutD protein as a query sequence. A blast cut-off(Evalue) of 0.01 was applied. This search resulted in 2124 sequencematches. Redundancy reduction was achieved by clustering proteins withthe CD-HIT program with parameters set at 95% sequence identity and 90%length overlap. The longest seed sequence, representative of eachcluster, is retained for further analysis. Clustering reduced the numberof protein sequences to 1336. Further clean-up of the sequences byremoving sequences <280 amino acids and sequences >795 amino acidsresulted in 1231 seqs.

The Brenda database was queried for experimentally verified phosphateacetyltransferases. Thirteen were found in the following organisms: S.enterica, E. coli K12, V. Parvula, C. Kluyveri, C. Acetobutylicum, C.Thermocellum, M. thermophile, S. pyogenes, B. subtilis, L. fermentum, L.plantarum, L. sanfranciscensis, B. subtilis, L. fermentum, L. plantarum,L. sanfranciscensis, R. palustris, E. coli.

Experimentally verified phosphate acetyltransferases (EC 2.3.1.8) belongto the PTA_PTB pfam family. However, the PTA_PTB domain is present in 13distinct architectures (http://pfam.janelia.org/family/PF01515, Pfamdatabase version 24). The motivation for investigating the domainarchitecture is to determine which of the proteins, that were identifiedby BLAST search, are likely to be phosphate acetyltransferases.

Experimentally verified sequences extracted from the BRENDA database aswell as sequences retained after the CD-HIT clustering and clean-up,were searched against the Pfam database to determine their domainarchitecture. Pfam is a collection of multiple sequence alignments andprofile hidden Markov models (HMMs). Each Pfam HMM represents a proteinfamily or domain. By searching a protein sequence against the Pfamlibrary of HMMs, it is possible to determine which domains it carriesi.e. its domain architecture. (The Pfam protein families database: R. D.Finn, J. Tate, J. Mistry, P. C. Coggill, J. S. Sammut, H. R. Hotz, G.Ceric, K. Forslund, S. R. Eddy, E. L. Sonnhammer and A. Bateman NucleicAcids Research (2008) Database Issue 36:D281-D288)

Twelve of the experimentally verified proteins only contained thePTA_PTB domain. Two sequences, from R. palustris and E. coli, containedtwo domains PTA_PTB and DRTGG, a domain of unknown function. Therefore,from the CD-HIT clustering results, proteins that contained either thePTA_PTB domain only (Group 1: 549 sequences) or a combination ofPTA_PTB+DRTGG domains (Group 2: 201 sequences) were chosen.

Furthermore, the PTA_PTB domain, as the name indicates, is actually notspecific to phosphate acetyltransferases. The domain is also a signaturefor phosphate butyryltransferases (EC 2.3.1.19). Two methods todistinguish between the two subfamilies: acetyltransferases andbutyryltransferases were employed and are as follows:

To further characterize the relationship among the sequences, multiplesequence alignment MSA), phylogenetic analysis, profile HMMs andGroupSim analysis were performed. For this set of analyses, thephosphate acetyltransferases are split in two groups. Group 1 containsphosphate acetyltransferases with the PTA_PTB domain only, while Group 2contains phosphate acetyltransferases with PTA_PTB+DRTGG. The motivationhere is to generate groups with similar lengths.

Clustal X, version 2.0 was used for sequence alignments with defaultparameters. (Thompson J D, et al. The CLUSTAL_X windows interface:flexible strategies for multiple sequence alignment aided by qualityanalysis tools. Nucleic Acids Res. (1997) 25:4876-4882.)

Alignment results were utilized to compute % sequence identities to areference sequence. If the sequence from L. plantarum is taken as areference, % IDs range from as low as 10.5% to 75.6% for the closestsequence. Alignment results also provided the basis for re-constructingphylogenetic trees. The Neighbor Joining method, available in theJalview package version 2.3, was used to produce the trees, and computedtrees were visualized in MEGA 4 (Tamura, Dudley, Nei, and Kumar 2007).The Neighbor Joining method is a method for re-constructing phylogenetictrees, and computing the lengths of the branches of this tree. In eachstage, the two nearest nodes of the tree (the term “nearest nodes” willbe defined in the following paragraphs) are chosen and defined asneighbors in our tree. This is done recursively until all of the nodesare paired together. “The neighbor joining method: a new method forreconstructing phylogenetic trees. Mol Biol Evol. 1987 July;4(4):406-25. Saitou N, Nei M.” Jalview Version 2 is a system forinteractive editing, analysis and annotation of multiple sequencealignments (Waterhouse, A. M., Procter, J. B., Martin, D. M. A, Clamp,M. and Barton, G. J. (2009) “Jalview Version 2—a multiple sequencealignment editor and analysis workbench” Bioinformatics 25 (9)1189-1191). The MEGA software provides tools for exploring, discovering,and analyzing DNA and protein sequences from an evolutionaryperspective. MEGA4 enables the integration of sequence acquisition withevolutionary analysis. It contains an array of input data and multipleresults explorers for visual representation; the handling and editing ofsequence data, sequence alignments, inferred phylogenetic trees; andestimated evolutionary distances. The results explorers allow users tobrowse, edit, summarize, export, and generate publication-qualitycaptions for their results. MEGA 4 also includes distance matrix andphylogeny explorers as well as advanced graphical modules for the visualrepresentation of input data and output results (Tamura K, Dudley J, NeiM & Kumar S (2007) MEGA4: Molecular Evolutionary Genetics Analysis(MEGA) software version 4.0. Molecular Biology and Evolution24:1596-1599).

Taken together, % IDs and the generated tree (FIG. 4) indicated thatpotential phosphate acetyltransferases (PTA_PTB domain only) are dividedin two major subfamilies. Subfamily 1 from 10.5% ID to ˜20% ID (176sequences) and Subfamily 2 from ˜20% ID to 75.6% ID (361 sequences). Thethird Subfamily, of 12 sequences, has % ID ranging from 17% ID to 25% IDwith respect to the L. plantarum sequence.

Based on experimentally verified sequences contained within each of theSubfamilies, Subfamily 1 and Subfamily 2 were determined to representphosphate butyryltransferases (PTB) and phosphate acetylytransferases(PTA) respectively.

Discrimination between Subfamily 1 members and Subfamily 2 members wasalso performed by GroupSim analysis (Capra and Singh (2008)Bioinformatics 24: 1473-1480). The GroupSim method identifies amino acidresidues that determine a protein's functional specificity. In amultiple sequence alignment (MSA) of a protein family whose sequencesare divided into multiple Subfamilies, amino acid residues thatdistinguish between the functional Subfamilies of sequences can beidentified. The method takes a multiple sequence alignment (MSA) andknown specificity groupings as input, and assigns a score to each aminoacid position in the MSA. Higher scores indicate a greater likelihoodthat an amino acid position is a specificity determining position (SDP).

GroupSim analysis performed on the MSA of 537 sequences (divided intoSubfamily 1 and Subfamily 2 by the phylogenetic analysis above)identified highly discriminating positions. Listed in Table 11 arepositions (Pos) having scores greater than to 0.7, where a perfect scoreof 1.0 would indicate that all proteins within the Subfamily have thelisted amino acid in the specified position and between Subfamilies theamino acid would always be different. The “Pattern” columns give theamino acid(s) in single letter code. Numbers between parenthesesindicate frequency of occurrence of each amino acid at the particularposition. The amino acid position number in column 1 is for the PTAprotein sequence from Lactobacillus plantarum, the representativeprotein of group 2 with a GI#28377658 (SEQ ID NO: 1472).

TABLE 11 Highly discriminating amino acid positions for Subfamily 1(PTB) and Subfamily 2 (PTA) from GroupSim analysis. Pos Score PatternPTB Pattern PTA 212 0.980314 Group 1: E(173), D(2), L(1) Group 2:S(360), N(1) 305 0.87236 Group 1: L(152), V(11), Group 2: D(360), Q(1)M(5), I(5), F(3) 242 0.831201 Group 1: A(142), D(15), Group 2: Q(361)S(13), G(4), T(2) 208 0.776954 Group 1: L(130), I(35), V(11) Group 2:S(355), A(6) 125 0.705868 Group 1: K(175), R(1) Group 2: S(215), A(85),G(41), C(14), N(4), T(2)

An alternative structure/function characterization of the PTA and PTBsubfamilies of enzymes was performed using the HMMER software package(the theory behind profile HMMs is described in R. Durbin, S. Eddy, A.Krogh, and G. Mitchison, Biological sequence analysis: probabilisticmodels of proteins and nucleic acids, Cambridge University Press, 1998;Krogh et al., 1994; J. Mol. Biol. 235:1501-1531), following the userguide which is available from HMMER (Janelia Farm Research Campus,Ashburn, Va.).

Using a multiple sequence alignment of the experimentally verifiedsequences (containing the PTA_PTB domain only) in Subfamily 2, a profileHidden Markov Model (HMM) was created for representing Subfamily 2members. The sequences were:

1. BAB19267.1 from Lactobacillus sanfranciscensis (SEQ ID NO: 1475)2. NP_(—)784550.1 from Lactobacillus plantarum WCFS1 (SEQ ID NO: 1472)3. ZP_(—)03944466.1 from Lactobacillus fermentum ATCC 14931 (SEQ ID NO:1453)4. NP_(—)391646.1 from Bacillus subtilis subsp. subtilis str. 168 (SEQID NO: 1422)5. AAA72041.1 from Methanosarcina thermophila (SEQ ID NO: 1277)6. ZP_(—)03152606.1 from Clostridium thermocellum DSM 4150 (SEQ ID NO:1275)7. NP_(—)348368.1 from Clostridium acetobutylicum ATCC 824 (SEQ ID NO:1206)8. YP_(—)001394780.1 from Clostridium kluyveri DSM 555 (SEQ ID NO: 1200)9. ZP_(—)03855267.1 from Veillonella parvula DSM 2008 (SEQ ID NO: 1159)10. YP_(—)149725.1 from Salmonella enterica subsp. enterica serovarParatyphi A str. ATCC 9150 (SEQ ID NO: 1129)

The Profile HMM was built as follows: The 10 seed sequences (sequencesrepresenting experimentally verified function) that are in Subfamily 2were aligned using Clustal X (interface to Clustal W) with defaultparameters. The hmmbuild program was run on each set of the alignedsequences using default parameters. hmmbuild reads the multiple sequencealignment file, builds a new Profile HMM, and saves the Profile HMM tofile. Using this program an un-calibrated profile was generated from themultiple alignment for each set of subunit sequences described above.

The Profile HMM was read using hmmcalibrate which scores a large numberof synthesized random sequences with the Profile (the default number ofsynthetic sequences used is 5,000), fits an extreme value distribution(EVD) to the histogram of those scores, and re-saves the HMM file nowincluding the EVD parameters. These EVD parameters (μ and λ) are used tocalculate the E-values of bit scores when the profile is searchedagainst a protein sequence database. hmmcalibrate writes two parametersinto the HMM file on a line labeled “EVD”: these parameters are the μ(location) and λ (scale) parameters of an extreme value distribution(EVD) that best fits a histogram of scores calculated on randomlygenerated sequences of about the same length and residue composition asSWISS-PROT. This calibration was done once for the Profile HMM.

The calibrated pofile HMM for the Subfamily 2 set is provided as Table14. The

Profile HMM table gives the probability of each amino acid occurring ateach position in the amino acid sequence. The amino acids arerepresented by the one letter code. The first line for each positionreports the match emission scores: probability for each amino acid to bein that state (highest score is highlighted). The second line reportsthe insert emission scores, and the third line reports on statetransition scores: M→M, M→I, M→D; I→M, I→I; D→M, D→D; B→M; M→E. Table 14shows that in the Subfamily 2 profile HMM, methionine has a 3792 ans4481 probability of being in the first two positions.

The Subfamily 2 profile HMM was evaluated using hmmsearch, with the Zparameter set to one billion, for the ability to discriminate Subfamily1 members from those of Subfamily 2. The hmmsearch program takes the hmmfile for the Subfamily 2 profile HMM and all the sequences from bothSubfamilies and assigns an E-value score to each sequence. This E-valuescore is a measure of fit to the Profile HMM, with a lower score being abetter fit. The Profile HMM distinguished Subfamily 2 members fromSubfamily 1 members and there was a large margin of E-value differencebetween the worst scoring Subfamily 2 member (5e-34) and the bestscoring Subfamily 1 member (4.3e-07). This analysis shows that theProfile HMM prepared for Subfamily 2 phosphate acetyltransferases (PTA)distinguishes PTA sequences from phosphate butyryltransferase PTBprotein sequences.

Based on these analyses, 361 phosphate acetyltransferase sequences(PTA_PTB domain only) were identified and are provided in Table 12a.

TABLE 12a SEQ ID NOs of phosphotransacetylase target gene coding regionsand proteins GENBANK Nucleotide Nucleic GENBANK Amino Sequence AcidAmino Acid Acid GI Accession SEQ Sequence SEQ ID Source NumberInformation ID NO: Accession No. NO: Organism 255994631 complement 762ZP_05427766.1 1123 Eubacterium (NZ_ACON01000003.1: saphenum 407639 . . .408607) ATCC 49989 223935781 NZ_ABOX02000007.1: 763 ZP_03627696.1 1124bacterium 10458 . . . 11600 Ellin514 196232920 NZ_ABVL01000018.1: 764ZP_03131770.1 1125 Chthoniobacter 134406 . . . 135449 flavus Ellin428187735919 NC_010655.1: 765 YP_001878031.1 1126 Akkermansia 1714393 . . .1715484 muciniphila ATCC BAA- 835 237732443 complement 766 ZP_04562924.11127 Citrobacter (NZ_GG657366.1: sp. 30_2 2437071 . . . 2438087)157144617 NC_009792.1: 767 YP_001451936.1 1128 Citrobacter 326993 . . .328009 koseri ATCC BAA-895 56412650 NC_006511.1: 768 YP_149725.1 1129Salmonella 473496 . . . 474512 enterica subsp. enterica serovarParatyphi A str. ATCC 9150 161502384 NC_010067.1: 769 YP_001569496.11130 Salmonella 425125 . . . 426141 enterica subsp. arizonae serovar 62:z4, z23: — 16130383 complement 770 NP_416953.1 1131 Escherichia(NC_000913.2: coli str. K-12 2570511 . . . 2571527) substr. MG1655238895918 complement 771 YP_002920654.1 1132 Klebsiella (NC_012731.1:pneumoniae 3863205 . . . 3864221) NTUH-K2044 238794182 complement 772ZP_04637797.1 1133 Yersinia (NZ_AALF02000025.1: intermedia 17041 . . .18039) ATCC 29909 90414632 complement 773 ZP_01222604.1 1134Photobacterium (NZ_AAPH01000046.1: profundum 12550 . . . 13527) 3TCK163749608 complement 774 ZP_02156855.1 1135 Shewanella(NZ_ABIC01000008.1: benthica 73942 . . . 74913) KT99 120554157NC_008740.1: 775 YP_958508.1 1136 Marinobacter 1389827 . . . 1390810aquaeolei VT8 51246887 complement 776 YP_066771.1 1137 Desulfotalea(NC_006138.1: psychrophila 3433697 . . . 3434677) LSv54 226362753complement 777 YP_002780531.1 1138 Rhodococcus (NC_012522.1: opacus B43613049 . . . 3614074) 111020534 complement 778 YP_703506.1 1139Rhodococcus (NC_008268.1: jostii RHA1 3751557 . . . 3752585) 256669010NZ_ACEV01000044.1: 779 ZP_05479963.1 1140 Streptomyces 80096 . . . 81085sp. AA4 226227292 complement 780 YP_002761398.1 1141 Gemmatimonas(NC_012489.1: aurantiaca 2203452 . . . 2204474) T-27 239627158complement 781 ZP_04670189.1 1142 Clostridiales (NZ_DS990260.1:bacterium 924717 . . . 925736) 1_7_47FAA 256753163 complement 782ZP_05493958.1 1143 Clostridium (NZ_ACXX01000001.1: papyrosolvens 167634. . . 168635) DSM 2782 257063834 NC_013165.1: 783 YP_003143506.1 1144Slackia 1278820 . . . 1279818 heliotrinireducens DSM 20476 254477436NZ_DS999054.1: 784 ZP_05090822.1 1145 Ruegeria sp. 3384063 . . . 3384914R11 126732220 complement 785 ZP_01748021.1 1146 Sagittula(NZ_AAYA01000016.1: stellata E-37 68052 . . . 68996) 19704507 complement786 NP_604069.1 1147 Fusobacterium (NC_003454.1: nucleatum 1833702 . . .1834715) subsp. nucleatum ATCC 25586 260494604 NZ_GG704456.1: 787ZP_05814734.1 1148 Fusobacterium 222376 . . . 223389 sp. 3_1_33262067001 complement 788 ZP_06026613.1 1149 Fusobacterium(NZ_ACJY01000064.1: periodonticum 9865 . . . 10869) ATCC 33693 257452333complement 789 ZP_05617632.1 1150 Fusobacterium (NZ_ACDD01000037.1: sp.3_1_5R 1250 . . . 2263) 257463639 NZ_ACDG01000104.1: 790 ZP_05628030.11151 Fusobacterium 17109 . . . 18122 sp. D12 253583748 complement 791ZP_04860946.1 1152 Fusobacterium (NZ_GG696122.1: varium 645905 . . .646912) ATCC 27725 237736963 NZ_GG657909.1: 792 ZP_04567444.1 1153Fusobacterium 489336 . . . 490343 mortiferum ATCC 9817 157736754complement 793 YP_001489437.1 1154 Arcobacter (NC_009850.1: butzleri500921 . . . 501916) RM4018 257125122 NC_013192.1: 794 YP_003163236.11155 Leptotrichia 327731 . . . 328735 buccalis C- 1013-b 260891157NZ_ACVB02000026.1: 795 ZP_05902420.1 1156 Leptotrichia 170989 . . .171993 hofstadii F0254 262037878 complement 796 ZP_06011308.1 1157Leptotrichia (NZ_ADAD01000064.1: goodfellowii 9188 . . . 10195) F0264229859891 NZ_ABUT01000004.1: 797 ZP_04479548.1 1158 Streptobacillus63190 . . . 64215 moniliformis DSM 12112 227371784 NZ_ABVB01000002.1:798 ZP_03855267.1 1159 Veillonella 260421 . . . 261419 parvula DSM 2008227498373 complement 799 ZP_03928523.1 1160 Acidaminococcus(NZ_ACGB01000001.1: sp. D21 109630 . . . 110643) 42525561 NC_002967.9:800 NP_970659.1 1161 Treponema 48816 . . . 49823 denticola ATCC 35405257456313 NZ_ACYH01000011.1: 801 ZP_05621510.1 1162 Treponema 210840 . .. 211847 vincentii ATCC 35580 15639088 NC_000919.1: 802 NP_218534.1 1163Treponema 102879 . . . 103889 pallidum subsp. pallidum str. Nichols228000316 complement 803 ZP_04047318.1 1164 Brachyspira(NZ_ABTG01000001.1: murdochii 1179041 . . . 1180048) DSM 12563 225619252NC_012225.1: 804 YP_002720478.1 1165 Brachyspira 340269 . . . 341276hyodysenteriae WA1 218960931 complement 805 YP_001740706.1 1166Candidatus (NS_000195.1: Cloacamonas 716420 . . . 717424)acidaminovorans 239878221 complement 806 EER05013.1 1167 Perkinsus(join(GG681098.1: marinus 49679 . . . 49966, ATCC 50983 GG681098.1:50017 . . . 50325, GG681098.1: 50380 . . . 50442, GG681098.1: 50494 . .. 50605, GG681098.1: 50656 . . . 50780, GG681098.1: 50826 . . . 50908,GG681098.1: 50958 . . . 51039)) 119953373 NC_008710.1: 807 YP_945582.11168 Borrelia 614125 . . . 615171 turicatae 91E135 187918450NC_010673.1: 808 YP_001884013.1 1169 Borrelia 616784 . . . 617842hermsii DAH 203284493 NC_011229.1: 809 YP_002222233.1 1170 Borrelia622676 . . . 623746 duttonii Ly 224534734 complement 810 ZP_03675306.11171 Borrelia (NZ_ABKB02000009.1: spielmanii 27640 . . . 28677) A14S216263399 NZ_ABCU02000001.1: 811 ZP_03435394.1 1172 Borrelia 172066 . .. 173103 afzelii ACA-1 219685198 NZ_ABPZ02000001.1: 812 ZP_03540018.11173 Borrelia 172004 . . . 173041 garinii Far04 224532296NZ_ABCY02000001.1: 813 ZP_03672928.1 1174 Borrelia 609419 . . . 610456valaisiana VS116 15594934 NC_001318.1: 814 NP_212723.1 1175 Borrelia608020 . . . 609078 burgdorferi B31 189485346 NS_000191.1: 815YP_001956287.1 1176 uncultured 518918 . . . 519919 Termite group 1bacterium phylotype Rs- D17 42560817 NC_005364.2: 816 NP_975268.1 1177Mycoplasma 308545 . . . 309513 mycoides subsp. mycoides SC str. PG183319483 NC_007633.1: 817 YP_424216.1 1178 Mycoplasma 277239 . . .278207 capricolum subsp. capricolum ATCC 27343 50364858 NC_006055.1: 818YP_053283.1 1179 Mesoplasma 58892 . . . 59860 florum L1 110005214complement 819 CAK99540.1 1180 Spiroplasma (AM285317.1: citri 14153 . .. 15130) 12045155 complement 820 NP_072966.1 1181 Mycoplasma(NC_000908.2: genitalium 368733 . . . 369695) G37 13508167 complement821 NP_110116.1 1182 Mycoplasma (NC_000912.1: pneumoniae 515605 . . .516567) M129 31544825 complement 822 NP_853403.1 1183 Mycoplasma(NC_004829.1: gallisepticum R 851083 . . . 852075) 26553955 complement823 NP_757889.1 1184 Mycoplasma (NC_004432.1: penetrans HF-2 640803 . .. 641777) 54020554 complement 824 YP_116016.1 1185 Mycoplasma(NC_006360.1: hyopneumoniae 638554 . . . 639507) 232 240047219NC_012806.1: 825 YP_002960607.1 1186 Mycoplasma 88435 . . . 89406conjunctivae 148377406 NC_009497.1: 826 YP_001256282.1 1187 Mycoplasma159649 . . . 160605 agalactiae PG2 238809713 complement 827 BAH69503.11188 Mycoplasma (AP009608.1: fermentans 242111 . . . 243064) PG1871894663 complement 828 YP_278771.1 1189 Mycoplasma (NC_007294.1:synoviae 53 757812 . . . 758771) 15828708 NC_002771.1: 829 NP_326068.11190 Mycoplasma 274992 . . . 275948 pulmonis UAB CTIP 47459003NC_006908.1: 830 YP_015865.1 1191 Mycoplasma 230100 . . . 231068 mobile163K 148377754 NC_009497.1: 831 YP_001256630.1 1192 Mycoplasma 572993 .. . 573967 agalactiae PG2 116515056 NC_008513.1: 832 YP_802685.1 1193Buchnera 131608 . . . 132594 aphidicola str. Cc (Cinara Cedri) 187934490NC_010674.1: 833 YP_001885432.1 1194 Clostridium 1263289 . . . 1264287botulinum B str. Eklund 17B 150016048 NC_009617.1: 834 YP_001308302.11195 Clostridium 1384403 . . . 1385404 beijerinckii NCIMB 8052 254519224complement 835 ZP_05131280.1 1196 Clostridium (NZ_EQ999773.1: sp.2015491 . . . 2016492) 7_2_43FAA 182417251 NZ_ABDT01000035.2: 836ZP_02948604.1 1197 Clostridium 9769 . . . 10770 butyricum 5521 18310707complement 837 NP_562641.1 1198 Clostridium (NC_003366.1: perfringens2001712 . . . 2002719) str. 13 255524273 complement 838 ZP_05391232.11199 Clostridium (NZ_ACVI01000014.1: carboxidivorans 63543 . . . 64547)P7 153954015 NC_009706.1: 839 YP_001394780.1 1200 Clostridium 1428554 .. . 1429555 kluyveri DSM 555 187778946 NZ_ABKW02000004.1: 840ZP_02995419.1 1201 Clostridium 733017 . . . 734015 sporogenes ATCC 1557928210926 NC_004557.1: 841 NP_781870.1 1202 Clostridium 1326340 . . .1327359 tetani E88 253681395 NZ_ACSJ01000007.1: 842 ZP_04862192.1 1203Clostridium 344343 . . . 345338 botulinum D str. 1873 118444574complement 843 YP_878298.1 1204 Clostridium (NC_008593.1: novyi NT1416375 . . . 1417373) 242260238 NZ_ACPD01000011.1: 844 ZP_04804960.11205 Clostridium 83320 . . . 84318 cellulovorans 743B 15895019NC_003030.1: 845 NP_348368.1 1206 Clostridium 1890289 . . . 1891290acetobutylicum ATCC 824 169247670 EU313773.1: 846 ACA51668.1 1207Thermoanaero 40 . . . 1026 bacterium saccharolyticum 255257449NZ_ACVG01000034.1: 847 ZP_05336886.1 1208 Thermoanaero 8635 . . . 9621bacterium thermosaccharolyticum DSM 571 20807926 complement 848NP_623097.1 1209 Thermoanaero (NC_003869.1: bacter 1451520 . . .1452515) tengcongensis MB4 167040369 complement 849 YP_001663354.1 1210Thermoanaero (NC_010320.1: bacter sp. 1738259 . . . 1739257) X514220931863 NC_011899.1: 850 YP_002508771.1 1211 Halothermothrix 1110901 .. . 1111899 orenii H 168 258514457 complement 851 YP_003190679.1 1212Desulfotomaculum (NC_013216.1: acetoxidans 1194895 . . . 1195899) DSM771 188586231 complement 852 YP_001917776.1 1213 Natranaerobius(NC_010718.1: thermophilus 1692944 . . . 1693942) JW/NM-WN- LF 78044760complement 853 YP_360288.1 1214 Carboxydothermus (NC_007503.1:hydrogenoformans 1302969 . . . 1303973) Z-2901 262295620 complement 854EEY83551.1 1215 Bacteroides (GG705150.1: sp. 2_1_33B 648642 . . .649655) 154494088 complement 855 ZP_02033408.1 1216 Parabacteroides(NZ_AAXE02000107.1: merdae 241237 . . . 242250) ATCC 43184 34540818complement 856 NP_905297.1 1217 Porphyromonas (NC_002950.2: asgingivalis 1149763 . . . 1150773) W83 228471187 complement 857ZP_04056000.1 1218 Porphyromonas (NZ_ACLR01000214.1: uenonis 60-3 23231. . . 24238) 229496164 NZ_ACNN01000020.1: 858 ZP_04389884.1 1219Porphyromonas 205218 . . . 206225 endodontalis ATCC 35406 160887812complement 859 ZP_2068815.1 1220 Bacteroides (NZ_AAYH02000031.1:uniformis 6367 . . . 7386) ATCC 8492 218131945 NZ_ABVO01000052.1: 860ZP_03460749.1 1221 Bacteroides 25694 . . . 26710 eggerthii DSM 20697224536405 complement 861 ZP_03676944.1 1222 Bacteroides(NZ_ACCH01000118.1: cellulosilyticus 1796 . . . 2812) DSM 14838 53711769NC_006347.1: 862 YP_097761.1 1223 Bacteroides 557297 . . . 558316fragilis YCH46 237715344 complement 863 ZP_04545825.1 1224 Bacteroides(NZ_EQ973249.1: sp. D1 217217 . . . 218236) 224025178 NZ_ACBW01000140.1:864 ZP_03643544.1 1225 Bacteroides 3350 . . . 4369 coprophilus DSM 18228198274546 NZ_ABQC02000011.1: 865 ZP_03207078.1 1226 Bacteroides 44269 .. . 45279 plebeius DSM 17135 150003111 NC_009614.1: 866 YP_001297855.11227 Bacteroides 740818 . . . 741831 vulgatus ATCC 8482 258649233complement 867 ZP_05736702.1 1228 Prevotella (NZ_ACIJ02000031.1:tannerae 14596 . . . 15612) ATCC 51259 261881160 NZ_ACKS01000109.1: 868ZP_06007587.1 1229 Prevotella 4227 . . . 5276 bergensis DSM 17361260593477 NZ_ACVA01000073.1: 869 ZP_05858935.1 1230 Prevotella 31053 . .. 32099 veroralis F0319 260910323 complement 870 ZP_05916997.1 1231Prevotella sp. (NZ_ACZS01000043.1: oral taxon 472 34220 . . . 35257)str. F0295 212550465 complement 871 YP_002308782.1 1232 Candidatus(NC_011565.1: Azobacteroides 126538 . . . 127539) pseudotrichonymphaegenomovar. CFP2 114566305 NC_008346.1: 872 YP_753459.1 1233Syntrophomonas 872558 . . . 873550 wolfei subsp. wolfei str. Goettingen139437229 NZ_AAVN02000001.1: 873 ZP_01771389.1 1234 Collinsella 368246 .. . 369226 aerofaciens ATCC 25986 210631306 complement 874 ZP_03296849.11235 Collinsella (NZ_ABXJ01000041.1: stercoris DSM 3328 . . . 4308)13279 229814970 complement 875 ZP_04445308.1 1236 Collinsella(NZ_ABXH02000002.1: intestinalis 65772 . . . 66770) DSM 13280 221194458complement 876 ZP_03567515.1 1237 Atopobium (NZ_ACFE01000001.1: rimaeATCC 86128 . . . 87273) 49626 257784450 complement 877 YP_003179667.11238 Atopobium (NC_013203.1: parvulum 723329 . . . 724309) DSM 20469227516084 complement 878 ZP_03946133.1 1239 Atopobium(NZ_ACGK01000007.1: vaginae DSM 63717 . . . 64691) 15829 227872296NZ_ACKX01000061.1: 879 ZP_03990654.1 1240 Oribacterium 10209 . . . 11261sinus F0268 229824780 NZ_ACIN02000002.1: 880 ZP_04450849.1 1241Abiotrophia 126870 . . . 127931 defectiva ATCC 49176 260443831NZ_ACIQ01000073.1: 881 ZP_05797601.1 1242 Oribacterium 32192 . . . 33196sp. oral taxon 078 str. F0262 225176688 complement 882 ZP_03730247.11243 Clostridium (NZ_ACFX01000006.1: sp. M62/1 113088 . . . 114089)253578981 complement 883 ZP_04856252.1 1244 Ruminococcus (NZ_GG696046.1:sp. 364564 . . . 365595) 5_1_39BFAA 153813664 NZ_AAVO02000036.1: 884ZP_01966332.1 1245 Ruminococcus 4823 . . . 5992 obeum ATCC 29174255281061 complement 885 ZP_05345616.1 1246 Bryantella(NZ_ACCL02000005.1: formatexigens 162813 . . . 163811) DSM 14469225571965 NZ_ACBZ01000008.1: 886 ZP_03780829.1 1247 Blautia 1408 . . .2442 hydrogenotrophica DSM 10507 210612569 NZ_ABWO01000095.2: 887ZP_03289360.1 1248 Clostridium 3132 . . . 4127 nexile DSM 1787 154505354complement 888 ZP_02042092.1 1249 Ruminococcus (NZ_AAYG02000022.1:gnavus 50151 . . . 51146) ATCC 29149 197303064 NZ_ABOU02000039.1: 889ZP_03168112.1 1250 Ruminococcus 71843 . . . 72838 lactaris ATCC 29176153816169 complement 890 ZP_01968837.1 1251 Ruminococcus(NZ_AAVP02000015.1: torques 36559 . . . 37554) ATCC 27756 1677582999complement 891 ZP_02430426.1 1252 Clostridium (NZ_ABFY02000009.1:scindens 238358 . . . 239380) ATCC 35704 225570721 NZ_ABYI02000032.1:892 ZP_03779744.1 1253 Clostridium 3477 . . . 4499 hylemonae DSM 15053166031766 NZ_AAXA02000013.1: 893 ZP_02234595.1 1254 Dorea 54410 . . .55414 formicigenerans ATCC 27755 153853264 complement 894 ZP_01994673.11255 Dorea (NZ_AAXB02000002.1: longicatena 216862 . . . 217857) DSM13814 160879474 NC_010001.1: 895 YP_001558442.1 1256 Clostridium 1657582. . . 1658577 phytofermentans ISDg 239624054 complement 896ZP_04667085.1 1257 Clostridiales (NZ_DS990263.1: bacterium 658578 . . .659573) 1_7_47FAA 160938034 complement 897 ZP_02085391.1 1258Clostridium (NZ_ABCC02000027.1: bolteae ATCC 52316 . . . 53311) BAA-613260437037 complement 898 ZP_05790853.1 1259 Butyrivibrio(NZ_ABWN01000017.1: crossotus 33488 . . . 34483) DSM 2876 154483586complement 899 ZP_02026034.1 1260 Eubacterium (NZ_AAVL02000033.1:ventriosum 74910 . . . 75941) ATCC 27560 238916996 complement 900YP_002930513.1 1261 Eubacterium (NC_012778.1: eligens ATCC 1076225 . . .1077220) 27750 242309058 NZ_DS990446.1: 901 ZP_04808213.1 1262Helicobacter 108718 . . . 109737 pullorum MIT 98-5489 224418114complement 902 ZP_03656120.1 1263 Helicobacter (NZ_ABQS01000024.1:canadensis 18744 . . . 19745) MIT 98-5491 237752737 NZ_GG661974.1: 903ZP_04583217.1 1264 Helicobacter 463241 . . . 464236 winghamensis ATCCBAA- 430 32266808 complement 904 NP_860840.1 1265 Helicobacter(NC_004917.1: hepaticus 1266998 . . . 1267993) ATCC 51449 224436915complement 905 ZP_03657896.1 1266 Helicobacter (NZ_ABQT01000013.1:cinaedi 10506 . . . 11522) CCUG 18818 167745652 complement 906ZP_02417779.1 1267 Anaerostipes (NZ_ABAX03000002.1: caccae DSM 101957 .. . 102961) 14662 167765558 complement 907 ZP_02437622.1 1268Clostridium (NZ_ABGC03000004.1: sp. SS2/1 50807 . . . 51820) 163814038NZ_ABEY02000003.1: 908 ZP_02205430.1 1269 Coprococcus 15727 . . . 16794eutactus ATCC 27759 168334441 complement 909 ZP_02692616.1 1270Epulopiscium (NZ_ABEQ01000029.2: sp. ‘N.t. 21420 . . . 22418) morphotypeB’ 257791476 NC_013204.1: 910 YP_003182082.1 1271 Eggerthella 2035882 .. . 2036880 lenta DSM 2243 256827068 complement 911 YP_003151027.1 1272Cryptobacterium (NC_013170.1: curtum 735166 . . . 736167) DSM 15641257063929 complement 912 YP_003143601.1 1273 Slackia (NC_013165.1:heliotrinireducens 1407526 . . . 1408521) DSM 20476 256757417 complement913 ZP_05498135.1 1274 Clostridium (NZ_ACXX01000078.1: papyrosolvens7706 . . . 8701) DSM 2782 196254011 NZ_ABVG01000076.1: 914 ZP_03152606.11275 Clostridium 9016 . . . 10092 thermocellum JW20 146297046 complement915 YP_001180817.1 1276 Caldicellulosiruptor (NC_009437.1:saccharolyticus 2185773 . . . 2186804) DSM 8903 349833 L23147.1: 207 . .. 1208 916 AAA72041.1 1277 Methanosarcina thermophila 20092407complement 917 NP_618482.1 1278 Methanosarcina (NC_003552.1: acetivorans4448053 . . . 4449054) C2A 73669327 complement 918 YP_305342.1 1279Methanosarcina (NC_007355.1: barkeri str. 2275987 . . . 2276988) Fusaro163734840 NZ_ABIG01000010.1: 919 ZP_02142278.1 1280 Roseobacter 132890 .. . 133867 litoralis Och 149 110678177 complement 920 YP_681184.1 1281Roseobacter (NC_008209.1: denitrificans 803709 . . . 804707) OCh 114159044374 complement 921 YP_001533168.1 1282 Dinoroseobacter(NC_009952.1: shibae DFL 1904769 . . . 1905794) 12 254512869NZ_DS999532.1: 922 ZP_05124935.1 1283 Rhodobacteraceae 435221 . . .436255 bacterium KLH11 260432366 complement 923 ZP_05786337.1 1284Silicibacter (NZ_GG704596.1: lacuscaerulensis 1443685 . . . 1444707)ITI-1157 150376990 NC_009620.1: 924 YP_001313586.1 1285 Sinorhizobium1371590 . . . 1372624 medicae WSM419 16264720 NC_003078.1: 925NP_437512.1 1286 Sinorhizobium 1058537 . . . 1059529 meliloti 1021239833801 complement 926 ZP_04682129.1 1287 Ochrobactrum(NZ_ACQA01000002.1: intermedium 595918 . . . 596886) LMG 3301 153010822complement 927 YP_001372036.1 1288 Ochrobactrum (NC_009668.1: anthropi862920 . . . 863897) ATCC 49188 187919084 complement 928 YP_001888115.11289 Burkholderia (NC_010676.1: phytofirmans 423371 . . . 424405) PsJN91779405 NC_007952.1: 929 YP_554613.1 1290 Burkholderia 2605754 . . .2606791 xenovorans LB400 186470979 NC_010625.1: 930 YP_001862297.1 1291Burkholderia 763673 . . . 764704 phymatum STM815 73537607 complement 931YP_297974.1 1292 Ralstonia (NC_007348.1: eutropha 372720 . . . 373757)JMP134 194292312 NC_010530.1: 932 YP_002008219.1 1293 Cupriavidus1692071 . . . 1693105 taiwanensis 161521061 NC_010086.1: 933YP_001584488.1 1294 Burkholderia 1600765 . . . 1601856 multivorans ATCC17616 206563034 complement 934 YP_002233797.1 1295 Burkholderia(NC_011001.1: cenocepacia 1288493 . . . 1289527) J2315 90412230complement 935 ZP_01220235.1 1296 Photobacterium (NZ_AAPH01000013.1:profundum 616 . . . 1653) 3TCK 224825256 complement 936 ZP_03698361.11297 Lutiella (NZ_ACIS01000005.1: nitroferrum 7593 . . . 8612) 2002148973982 complement 937 ZP_01811515.1 1298 Vibrionales(NZ_AAZW01000001.1: bacterium 115872 . . . 116945) SWAT-3 84385317complement 938 ZP_00988349.1 1299 Vibrio (NZ_AAMR01000001.1: splendidus227808 . . . 228881) 12B01 149187938 NZ_ABCH01000003.1: 939ZP_01866234.1 1300 Vibrio 163877 . . . 164926 shilonii AK1 260776268complement 940 ZP_05885163.1 1301 Vibrio (NZ_ACZN01000015.1:coralliilyticus 316917 . . . 317966) ATCC BAA- 450 45862014 AY498613.1:941 AAS78789.1 1302 Paracoccus 8897 . . . 9853 denitrificans 77404622NC_007488.1: 942 YP_345196.1 1303 Rhodobacter 38175 . . . 39173sphaeroides 2.4.1 23630309 AY134843.1: 943 AAN08490.1 1304Castellaniella 2180 . . . 3148 defragrans 83952615 NZ_AALY01000004.1:944 ZP_00961345.1 1305 Roseovarius 6833 . . . 7819 nubinhibens ISM56698382 complement 945 YP_168755.1 1306 Ruegeria (NC_003911.11:pomeroyi 3772593 . . . 3773606) DSS-3 149912659 NZ_ABCR01000001.1: 946ZP_01901193.1 1307 Roseobacter 262172 . . . 263161 sp. AzwK-3b 126736835complement 947 ZP_01752570.1 1308 Roseobacter (NZ_AAYC01000001.1: sp.SK209-2-6 23010 . . . 24029) 163732628 complement 948 ZP_02140073.1 1309Roseobacter (NZ_ABIG01000003.1: litoralis Och 152433 . . . 153374) 14989055338 NC_007802.1: 949 YP_510789.1 1310 Jannaschia sp. 2864232 . . .2865239 CCS1 254459737 NZ_DS995276.1: 950 ZP_05073153.1 1311Rhodobacterales 713420 . . . 714472 bacterium HTCC2083 116620211NC_008536.1: 951 YP_822367.1 1312 Candidatus 1336713 . . . 1337708Solibacter usitatus Ellin6076 95930364 NZ_AAEW02000012.1: 952ZP_01313101.1 1313 Desulfuromonas 74280 . . . 75281 acetoxidans DSM 68477920135 NC_007498.2: 953 YP_357950.1 1314 Pelobacter 2984046 . . .2985047 carbinolicus DSM 2380 222054722 complement 954 YP_002537084.11315 Geobacter sp. (NC_011979.1: FRC-32 1793784 . . . 1794785) 148265418NC_009483.1: 955 YP_001232124.1 1316 Geobacter 3992460 . . . 3993461uraniireducens Rf4 39997800 NC_002939.4: 956 NP_953751.1 1317 Geobacter2984470 . . . 2985471 sulfurreducens PCA 78222253 complement 957YP_384000.1 1318 Geobacter (NC_007517.1: metallireducens 1150703 . . .1151704) GS-15 118579718 complement 958 YP_900968.1 1319 Pelobacter(NC_008609.1: propionicus 1359173 . . . 1360177) DSM 2379 189424275complement 959 YP_001951452.1 1320 Geobacter (NC_010814.1: lovleyi SZ1256052 . . . 1257053) 255059775 NZ_ACPJ01000030.1: 960 ZP_05311922.11321 Geobacter sp. 50425 . . . 51426 M18 253700569 complement 961YP_003021758.1 1322 Geobacter sp. (NC_012918.1: M21 2257017 . . .2258018) 77920440 complement 962 YP_358255.1 1323 Pelobacter(NC_007498.2: carbinolicus 3332135 . . . 3333136) DSM 2380 227423754NZ_ABTN01000011.1: 963 ZP_03906856.1 1324 Denitrovibrio 41883 . . .42872 acetiphilus DSM 12809 193215894 NC_011026.1: 964 YP_001997093.11325 Chloroherpeton 2629909 . . . 2630916 thalassium ATCC 35110150386298 complement 965 ZP_01924858.1 1326 Victivallis(NZ_ABDE01000122.1: vadensis 6609 . . . 7619) ATCC BAA- 548 217034411NZ_ABSX01000018.1: 966 ZP_03439825.1 1327 Helicobacter 29972 . . . 31570pylori 98-10 254779508 complement 967 YP_003057614.1 1328 Helicobacter(NC_012973.1: pylori B38 876982 . . . 878538) 188527730 complement 968YP_001910417.1 1329 Helicobacter (NC_010698.2: pylori Shi470 936737 . .. 938293) 15611908 complement 969 NP_223559.1 1330 Helicobacter(NC_000921.1: pylori J99 920263 . . . 921822) 109947805 complement 970YP_665033.1 1331 Helicobacter (NC_008229.1: acinonychis 1105678 . . .1107201) str. Sheeba 148926656 NZ_AASY01000008.1: 971 ZP_01810337.1 1332Campylobacter 52243 . . . 53778 jejuni subsp. jejuni CG8486 57167700complement 972 ZP_00366840.1 1333 Campylobacter (NZ_AAFL01000001.1: coli232544 . . . 234046) RM2228 57242590 complement 973 ZP_00370527.1 1334Campylobacter (NZ_AAFJ01000004.1: upsaliensis 6136 . . . 7638) RM3195222823645 NC_012039.1: 974 YP_002575219.1 1335 Campylobacter 612447 . .. 613916 lari RM2100 154148075 complement 975 YP_001406718.1 1336Campylobacter (NC_009714.1: hominis 1098161 . . . 1099597) ATCC BAA- 381257459711 NZ_ACYG01000019.1: 976 ZP_05624820.1 1337 Campylobacter 245785. . . 247383 gracilis RM3268 118475502 complement 977 YP_891988.1 1338Campylobacter (NC_008599.1: fetus subsp. 824533 . . . 825927) fetus82-40 157164211 NC_009802.1: 978 YP_001466901.1 1339 Campylobacter1056736 . . . 1058103 concisus 13826 154173700 complement 979YP_001408221.1 1340 Campylobacter (NC_009715.1: curvus 947742 . . .949112) 525.92 255322202 NZ_ACVQ01000017.1: 980 ZP_05363348.1 1341Campylobacter 43696 . . . 45081 showae RM3277 225351910NZ_ABXX02000003.1: 981 ZP_03742933.1 1342 Bifidobacterium 117844 . . .119514 pseudocatenulatum DSM 20438 171743080 complement 982ZP_02918887.1 1343 Bifidobacterium (NZ_ABIX02000002.1: dentium 2348529 .. . 2350229) ATCC 27678 154487476 complement 983 ZP_02028883.1 1344Bifidobacterium (NZ_AAXD02000028.1: adolescentis 209751 . . . 211442)L2-32 229817818 complement 984 ZP_04448100.1 1345 Bifidobacterium(NZ_ABYS02000004.1: angulatum 899528 . . . 901234) DSM 20098 223467350complement 985 ZP_03618886.1 1346 Bifidobacterium (NZ_ACCG01000014.1:breve DSM 93417 . . . 95159) 20213 227546035 NZ_ACHI01000009.1: 986ZP_03976084.1 1347 Bifidobacterium 13043 . . . 14755 longum subsp.infantis ATCC 55813 213692597 NC_011593.1: 987 YP_002323183.1 1348Bifidobacterium 1898224 . . . 1899936 longum subsp. infantis ATCC 15697224282865 complement 988 ZP_03646187.1 1349 Bifidobacterium(NZ_ABQP01000009.1: bifidum 208984 . . . 210654) NCIMB 41171 227507562NZ_ACGF01000124.1: 989 ZP_03937611.1 1350 Gardnerella 44384 . . . 46048vaginalis ATCC 14019 183601499 complement 990 ZP_02962869.1 1351Bifidobacterium (NZ_ABOT01000001.1: animalis 192971 . . . 194653) subsp.lactis HN019 261337301 complement 991 ZP_05965185.1 1352 Bifidobacterium(NZ_ABXB03000001.1: gallicum 137782 . . . 139455) DSM 20093 154507766NZ_AAYI02000004.1: 992 ZP_02043408.1 1353 Actinomyces 231567 . . .233045 odontolyticus ATCC 17982 227494860 complement 993 ZP_03925176.11354 Actinomyces (NZ_ACFG01000030.1: coleocanis 86700 . . . 88295) DSM15436 19553946 complement 994 NP_601948.1 1355 Corynebacterium(NC_003450.3: glutamicum 2936506 . . . 2937891) ATCC 13032 25029147complement 995 NP_739201.1 1356 Corynebacterium (NC_004369.1: efficiens2758982 . . . 2760496) YS-314 38234612 complement 996 NP_940379.1 1357Corynebacterium (NC_002935.2: diphtheriae 2103677 . . . 2105128) NCTC13129 252124104 complement 997 ZP_04835255.1 1358 Corynebacterium(NZ_ACSH01000003.1: matruchotii 61905 . . . 63305) ATCC 14266 227489285NZ_ABYP01000094.1: 998 ZP_03919601.1 1359 Corynebacterium 61648 . . .63048 glucuronolyticum ATCC 51867 258561950 NZ_ACLJ01000070.1: 999ZP_05708623.1 1360 Corynebacterium 13162 . . . 14523 genitalium ATCC33030 227547861 NZ_ACHJ01000017.1: 1000 ZP_03977910.1 1361Corynebacterium 9541 . . . 10899 lipophiloflavum DSM 44291 227502015NZ_ACGD01000004.1: 1001 ZP_03932064.1 1362 Corynebacterium 82938 . . .84305 accolens ATCC 49725 255325798 NZ_ACVP01000037.1: 1002ZP_05366890.1 1363 Corynebacterium 5746 . . . 7107 tuberculostearicumSK141 227505901 NZ_ACGE01000122.1: 1003 ZP_03935950.1 1364Corynebacterium 37468 . . . 38826 striatum ATCC 6940 227834110complement 1004 YP_002835817.1 1365 Corynebacterium (NC_012590.1:aurimucosum 2492850 . . . 2494214) ATCC 700975 68535315 NC_007164.1:1005 YP_250020.1 1366 Corynebacterium 307337 . . . 308848 jeikeium K411172041418 complement 1006 YP_001801132.1 1367 Corynebacterium(NC_010545.1: urealyticum 2018026 . . . 2019369) DSM 7109 237786249complement 1007 YP_002906954.1 1368 Corynebacterium (NC_012704.1:kroppenstedtii 1975731 . . . 1977287) DSM 44385 213965099 complement1008 ZP_03393297.1 1369 Corynebacterium (NZ_ABZU01000003.1: amycolatum128017 . . . 129543) SK46 225075788 complement 1009 ZP_03718987.1 1370Neisseria (NZ_ACEN01000020.1: flavescens 5387 . . . 6889) NRL30031/H210255067101 NZ_ACKO02000012.1: 1010 ZP_05318956.1 1371 Neisseria 64851 . .. 66353 sicca ATCC 29256 161869564 complement 1011 YP_001598731.1 1372Neisseria (NC_010120.1: meningitidis 603202 . . . 604836) 053442238022551 NZ_ACJW02000003.1: 1012 ZP_04602977.1 1373 Kingella 751672 . .. 753150 oralis ATCC 51147 83592714 complement 1013 YP_426466.1 1374Rhodospirillum (NC_007643.1: rubrum 1625036 . . . 1626802) ATCC 1117032490929 complement 1014 NP_871183.1 1375 Wigglesworthia (NC_004344.2:glossinidia 212680 . . . 214818) endosymbiont of Glossina brevipalpis27904667 NC_004545.1: 1015 NP_777793.1 1376 Buchnera 186377 . . . 188524aphidicola str. Bp (Baizongia pistaciae) 261415723 complement 1016YP_003249406.1 1377 Fibrobacter (NC_013410.1: succinogenes 1639393 . . .1640796) subsp. succinogenes S85 219556226 NZ_ABQH01000061.1: 1017ZP_03535302.1 1378 Mycobacterium <3 . . . 1196 tuberculosis T17228471665 complement 1018 ZP_04056438.1 1379 Capnocytophaga(NZ_ACLQ01000003.1: gingivalis 154599 . . . 155657) ATCC 33624 256370675NC_013123.1: 1019 YP_003108500.1 1380 Candidatus 116952 . . . 117950Sulcia muelleri SMDSEM 6685772 X89084.1: 1009 . . . 199 1020 P77844 1381Corynebacterium glutamicum 227876041 NZ_ACKW01000045.1: 1021ZP_03994160.1 1382 Mobiluncus 33898 . . . 34887 mulieris ATCC 35243227492324 NZ_ACCQ01000004.1: 1022 ZP_03922640.1 1383 Mobiluncus 214416 .. . 215417 curtisii ATCC 43063 225027017 NZ_ACEP01000064.1: 1023ZP_03716209.1 1384 Eubacterium 10650 . . . 11609 hallii DSM 3353225028951 complement 1024 ZP_03718143.1 1385 Eubacterium(NZ_ACEP01000172.1: hallii DSM 22364 . . . 23416) 3353 257438679complement 1025 ZP_05614434.1 1386 Faecalibacterium (NZ_ACOP02000029.1:prausnitzii 99 . . . 1124) A2-165 154496156 complement 1026ZP_02034852.1 1387 Bacteroides (NZ_AAXG02000004.1: capillosus 103391 . .. 104380) ATCC 29799 225376322 NZ_ACFY01000086.1: 1027 ZP_03753543.11388 Roseburia 6940 . . . 7992 inulinivorans DSM 16841 257414121complement 1028 ZP_04745275.2 1389 Roseburia (NZ_ABYJ02000202.1:intestinalis 41125 . . . 42165) L1-82 238923816 NC_012781.1: 1029YP_002937332.1 1390 Eubacterium 1324280 . . . 1325263 rectale ATCC 33656160893459 NZ_AAYW02000007.1: 1030 ZP_02074244.1 1391 Clostridium 63870 .. . 64919 sp. L2-50 229829305 complement 1031 ZP_04455374.1 1392Shuttleworthia (NZ_ACIP02000002.1: satelles 495313 . . . 496299) DSM14600 218282181 complement 1032 ZP_03488480.1 1393 Eubacterium(NZ_ABYT01000061.1: biforme DSM 45 . . . 1016) 3989 160916120 complement1033 ZP_02078327.1 1394 Eubacterium (NZ_ABAW02000025.1: dolichum 71684 .. . 72694) DSM 3991 160915347 NZ_ABAW02000020.1: 1034 ZP_02077559.1 1395Eubacterium 14646 . . . 15638 dolichum DSM 3991 212697404NZ_ABXA01000047.1: 1035 ZP_03305532.1 1396 Anaerococcus 41715 . . .42701 hydrogenalis DSM 7454 256545936 complement 1036 ZP_05473291.1 1397Anaerococcus (NZ_ACXU01000022.1: vaginalis 22101 . . . 23087) ATCC 51170227501001 NZ_ACGC01000115.1: 1037 ZP_03931050.1 1398 Anaerococcus 23122. . . 24108 tetradius ATCC 35098 257067207 complement 1038YP_003153463.1 1399 Anaerococcus (NC_013171.1: prevotii DSM 1868769 . .. 1869752) 20548 227485732 complement 1039 ZP_03916048.1 1400Anaerococcus (NZ_ABYO01000196.1: lactolyticus 43814 . . . 44833) ATCC51172 19746077 NC_003485.1: 1040 NP_607213.1 1401 Streptococcus 903788 .. . 904783 pyogenes MGAS8232 13622266 AE004092.1: 1041 AAK34003.1 1402Streptococcus 923921 . . . 924916 pyogenes M1 GAS 222153008 NC_012004.1:1042 YP_002562185.1 1403 Streptococcus 834034 . . . 835026 uberis 0140J225868503 NC_012470.1: 1043 YP_002744451.1 1404 Streptococcus 1034662 .. . 1035663 equi subsp. Zooepidemicus 254997415 AP010655.1: 1044BAH88016.1 1405 Streptococcus 1031526 . . . 1032521 mutans NN2025171779341 NZ_ABJK02000020.1: 1045 ZP_02920305.1 1406 Streptococcus 38474. . . 39472 infantarius subsp. infantarius ATCC BAA- 102 76787123complement 1046 YP_329798.1 1407 Streptococcus (NC_007432.1: agalactiae1155758 . . . 1156750) A909 228477151 complement 1047 ZP_04061789.1 1408Streptococcus (NZ_ACLO01000062.1: salivarius 54543 . . . 55526) SK12655821439 complement 1048 YP_139881.1 1409 Streptococcus (NC_006448.1:thermophilus 1286014 . . . 1286997) LMG 18311 237650772NZ_ABZC01000093.1: 1049 ZP_04525024.1 1410 Streptococcus 10653 . . .11627 pneumoniae CCRI 1974 262282806 complement 1050 ZP_06060573.1 1411Streptococcus (NZ_GG704941.1: sp. 11119 . . . 12096) 2_1_36FAA 146318711complement 1051 YP_001198423.1 1412 Streptococcus (NC_009442.1: suis1032399 . . . 1033379) 05ZYH33 42518809 NC_005362.1: 1052 NP_964739.11413 Lactobacillus 788505 . . . 789482 johnsonii NCC 533 58337025NC_006814.3: 1053 YP_193610.1 1414 Lactobacillus 698578 . . . 699567acidophilus NCFM 227893214 NZ_ACGU01000037.1: 1054 ZP_04011019.1 1415Lactobacillus 27358 . . . 28347 ultunensis DSM 16047 227877224NZ_ACKR01000025.1: 1055 ZP_03995297.1 1416 Lactobacillus 14947 . . .15936 crispatus JV- V01 260102516 NZ_ACLM01000112.1: 1056 ZP_05752753.11417 Lactobacillus 6924 . . . 7913 helveticus DSM 20075 227525975NZ_ACGQ01000041.1: 1057 ZP_03956024.1 1418 Lactobacillus 59881 . . .60858 jensenii JV- V16 238854857 complement 1058 ZP_04645187.1 1419Lactobacillus (NZ_ACOY01000013.1: jensenii 269-3 251390 . . . 252367)104773739 NC_008054.1: 1059 YP_618719.1 1420 Lactobacillus 547017 . . .548006 delbrueckii subsp. bulgaricus ATCC 11842 259501464NZ_ACLN01000013.1: 1060 ZP_05744366.1 1421 Lactobacillus 15438 . . .16418 iners DSM 13335 16080818 complement 1061 NP_391646.1 1422 Bacillus(NC_000964.3: subtilis subsp. 3865355 . . . 3866326) subtilis str. 168154687884 complement 1062 YP_001423045.1 1423 Bacillus (NC_009725.1:amyloliquefaciens 3590964 . . . 3591935) FZB42 52082282 complement 1063YP_081073.1 1424 Bacillus (NC_006270.3: licheniformis 3821313 . . .3822284) ATCC 14580 194016487 complement 1064 ZP_03055101.1 1425Bacillus (NZ_ABRX01000004.1: pumilus 144981 . . . 145952) ATCC 7061212640578 complement 1065 YP_002317098.1 1426 Anoxybacillus(NC_011567.1: flavithermus 2748264 . . . 2749247) WK1 239828646complement 1066 YP_002951270.1 1427 Geobacillus (NC_012793.1: sp. WCH703393094 . . . 3394068) 138896990 complement 1067 YP_001127443.1 1428Geobacillus (NC_009328.1: thermodenitrificans 3468960 . . . 3469934)NG80-2 56421950 complement 1068 YP_149268.1 1429 Geobacillus(NC_006510.1: kaustophilus 3456185 . . . 3457165) HTA426 149182788NZ_ABCF01000043.1: 1069 ZP_01861251.1 1430 Bacillus sp. 11583 . . .12554 SG-1 205375387 NZ_ABFU01000065.2: 1070 ZP_03228176.1 1431 Bacillus12128 . . . 13099 coahuilensis m4-4 89101108 complement 1071ZP_01173945.1 1432 Bacillus sp. (NZ_AAOX01000058.1: NRRL B- 10738 . . .11715) 14911 23100477 complement 1072 NP_693944.1 1433 Oceanobacillus(NC_004193.1: iheyensis 3134492 . . . 3135466) HTE831 229187615complement 1073 ZP_04314753.1 1434 Bacillus (NZ_ACLU01000117.1: cereusBGSC6E1 31676 . . . 32647) 46908338 complement 1074 YP_014727.1 1435Listeria (NC_002973.6: monocytogenes 2171357 . . . 2172334) str. 4bF2365 229555968 NZ_ACCR01000020.1: 1075 ZP_04443757.1 1436 Listeriagrayi 18426 . . . 19403 DSM 20601 15616385 complement 1076 NP_244690.11437 Bacillus (NC_002570.2: halodurans C- 3947889 . . . 3948881) 12556965668 complement 1077 YP_177402.1 1438 Bacillus (NC_006582.1: clausiiKSM- 4069370 . . . 4070365) K16 229917170 complement 1078 YP_002885816.11439 Exiguobacterium (NC_012673.1: sp. AT1b 1410227 . . . 1411216)172056261 NC_010556.1: 1079 YP_001812721.1 1440 Exiguobacterium 233988 .. . 234974 sibiricum 255-15 163762281 NZ_ABHZ01000002.1: 1080ZP_02169346.1 1441 Bacillus 94480 . . . 95457 selenitireducens MLS10242372812 NZ_ACJB01000048.1: 1081 ZP_04818386.1 1442 Staphylococcus 8122. . . 9111 epidermidis M23864: W1 223042925 complement 1082ZP_03612973.1 1443 Staphylococcus (NZ_ACFR01000002.1: capitis 330954 . .. 331943) SK14 239636796 complement 1083 ZP_04677798.1 1444Staphylococcus (NZ_ACPZ01000027.1: warneri 569915 . . . 570904) L3760327467277 NC_004461.1: 1084 NP_763914.1 1445 Staphylococcus 356818 . . .357807 epidermidis ATCC 12228 258422775 NZ_ACKI01000006.1: 1085ZP_05685678.1 1446 Staphylococcus 980 . . . 1966 aureus A9635 70727403complement 1086 YP_254319.1 1447 Staphylococcus (NC_007168.1:haemolyticus 2403280 . . . 2404269) JCSC1435 228475091NZ_ACLP01000011.1: 1087 ZP_04059818.1 1448 Staphylococcus 16037 . . .17026 hominis SK119 150011041 EF456699.1: 1088 ABR57177.1 1449Staphylococcus 1 . . . 987 xylosus 73663433 complement 1089 YP_302214.11450 Staphylococcus (NC_007350.1: saprophyticus 2190871 . . . 2191857)subsp. saprophyticus ATCC 15305 224475734 NC_012121.1: 1090YP_002633340.1 1451 Staphylococcus 250258 . . . 251247 carnosus subsp.carnosus TM300 222152076 complement 1091 YP_002561236.1 1452 Macrococcus(NC_011999.1: caseolyticus 1968130 . . . 1969119) JCSC5402 227514417NZ_ACGI01000058.1: 1092 ZP_03944466.1 1453 Lactobacillus 71225 . . .72199 fermentum ATCC 14931 256848058 complement 1093 ZP_05553502.1 1454Lactobacillus (NZ_GG698804.1: coleohominis 125094 . . . 126059)101-4-CHN 227529580 NZ_ACGV01000117.1: 1094 ZP_03959629.1 1455Lactobacillus 1634 . . . 2608 vaginalis ATCC 49540 148543634NC_009513.1: 1095 YP_001271004.1 1456 Lactobacillus 451991 . . . 452965reuteri DSM 20016 259502766 NZ_ACLL01000024.1: 1096 ZP_05745668.1 1457Lactobacillus 18101 . . . 19072 antri DSM 16041 116618560 complement1097 YP_818931.1 1458 Leuconostoc (NC_008531.1: mesenteroides 1461235 .. . 1462215) subsp. mesenteroides ATCC 8293 170016912 NC_010471.1: 1098YP_001727831.1 1459 Leuconostoc 577967 . . . 578959 citreum KM20241894748 complement 1099 ZP_04782044.1 1460 Weissella(NZ_ACKU01000002.1: paramesenteroides 15496 . . . 16476) ATCC 33313118587037 NZ_AAUV01000054.1: 1100 ZP_01544468.1 1461 Oenococcus 44038 .. . 45132 oeni ATCC BAA-1163 259046893 complement 1101 ZP_05737294.11462 Granulicatella (NZ_ACKZ01000012.1: adiacens 86436 . . . 87425) ATCC49175 260584167 complement 1102 ZP_05851915.1 1463 Granulicatella(NZ_GG703805.1: elegans 786281 . . . 787264) ATCC 700633 163789527complement 1103 ZP_02183965.1 1464 Carnobacterium (NZ_ABHH01000002.1:sp. AT7 8081 . . . 9061) 257870102 NZ_GG670288.1: 1104 ZP_05649755.11465 Enterococcus 145742 . . . 146725 gallinarum EG2 227517869NZ_ACGL01000051.1: 1105 ZP_03947918.1 1466 Enterococcus 2376 . . . 3401faecalis TX0104 227552175 complement 1106 ZP_03982224.1 1467Enterococcus (NZ_ACHL01000118.1: faecium 1216 . . . 2232) TX133081428954 complement 1107 YP_395954.1 1468 Lactobacillus (NC_007576.1:sakei subsp. 1313600 . . . 1314586) sakei 23K 229823693NZ_ACIL02000007.1: 1108 ZP_04449762.1 1469 Catonella 6499 . . . 7482morbi ATCC 51271 125623617 NC_009004.1: 1109 YP_001032100.1 1470Lactococcus 752099 . . . 753079 lactis subsp. cremoris MG1363 116494500NC_008526.1: 1110 YP_806234.1 1471 Lactobacillus 981403 . . . 982380casei ATCC 334 28377658 NC_004567.1: 1111 NP_784550.1 1472 Lactobacillus748192 . . . 749169 plantarum WCFS1 116333321 NC_008497.1: 1112YP_794848.1 1473 Lactobacillus 702374 . . . 703348 brevis ATCC 367227524782 complement 1113 ZP_03954831.1 1474 Lactobacillus(NZ_ACGP01000192.1: hilgardii 2135 . . . 3112) ATCC 8290 11862872AB035800.1: 1114 BAB19267.1 1475 Lactobacillus 1006 . . . 1992sanfranciscensis 227528239 NZ_ACGS01000093.1: 1115 ZP_03958288.1 1476Lactobacillus 64718 . . . 65695 ruminis ATCC 25644 90962126 complement1116 YP_536042.1 1477 Lactobacillus (NC_007929.1: salivarius 1183945 . .. 1184922) UCC118 259504733 NZ_ACLK01000016.1: 1117 ZP_05747635.1 1478Erysipelothrix 55937 . . . 56917 rhusiopathiae ATCC 19414 116492140NC_008525.1: 1118 YP_803875.1 1479 Pediococcus 385259 . . . 386230pentosaceus ATCC 25745 160946581 NZ_ABEE02000016.1: 1119 ZP_02093784.11480 Parvimonas 72101 . . . 73072 micra ATCC 33270 169825312 complement1120 YP_001692923.1 1481 Finegoldia (NC_010376.1: magna ATCC 1782855 . .. 1783826) 29328 229542439 NZ_AAWV02000001.1: 1121 ZP_04431499.1 1482Bacillus 1452854 . . . 1453825 coagulans 36D1 241888505NZ_ACDZ02000004.1: 1122 ZP_04775813.1 1483 Gemella 11622 . . . 12602haemolysans ATCC 10379

In addition, 201 phosphate acetyltransferase sequences that arecharacterized by two domains (DRTGG and PTA_PTB) are provided in Table12b. MSA and phylogenetic analysis were performed as described above.Percent identity with respect to experimentally verified (or humancurated) sequences is equal to or larger than 40, except for 4 sequencesderived from plant organisms. Furthermore, hmmer search of the 201sequences against the profile HMM of subfamily 2 (Table 14), clearlyindicates that all Group 2 sequences belong to the PTA subfamily (leastsignificant Evalue is 4.1e-93).

TABLE 12b SEQ ID NOs of phosphotransacetylase target gene coding regionsand proteins GENBANK GENBANK Amino Nucleotide Sequence Nucleic AminoAcid Acid GI Accession Acid SEQ Sequence SEQ Source Number InformationID NO: Accession No. ID NO: Organism 152964825 complement(NC_009664.2:1484 YP_001360609.1 1685 Kineococcus 1430885 . . . 1432984)radiotolerans SRS30216 88800302 complement(NZ_AAOE01000024.1: 1485ZP_01115869.1 1686 Reinekea 59450 . . . 61609) blandensis MED297254786809 complement(NC_012997.1: 1486 YP_003074238.1 1687Teredinibacter 3139764 . . . 3141917) turnerae T7901 120554060complement(NC_008740.1: 1487 YP_958411.1 1688 Marinobacter 1283732 . . .1285885) aquaeolei VT8 83647145 NC_007645.1: 4579211 . . . 4581358 1488YP_435580.1 1689 Hahella chejuensis KCTC 2396 146308660 NC_009439.1:4021959 . . . 4024052 1489 YP_001189125.1 1690 Pseudomonas mendocina ymp116048757 NC_008463.1: 4740071 . . . 4742185 1490 YP_792443.1 1691Pseudomonas aeruginosa UCBPP-PA14 28868382 complement(NC_004578.1: 1491NP_791001.1 1692 Pseudomonas 1283902 . . . 1285992) syringae pv. tomatostr. DC3000 70728320 complement(NC_004129.6: 1492 YP_258069.1 1693Pseudomonas 1081214 . . . 1083313) fluorescens Pf-5 104780139complement(NC_008027.1: 1493 YP_606637.1 1694 Pseudomonas 952666 . . .954756) entomophila L48 226945506 complement(NC_012560.1: 1494YP_002800579.1 1695 Azotobacter 3530138 . . . 3532276) vinelandii DJ146281510 complement(NC_009434.1: 1495 YP_001171663.1 1696 Pseudomonas1238536 . . . 1240632) stutzeri A1501 30248315 complement(NC_004757.1:1496 NP_840385.1 1697 Nitrosomonas 326321 . . . 328408) europaea ATCC19718 226946148 NC_012560.1: 4145609 . . . 4147684 1497 YP_002801221.11698 Azotobacter vinelandii DJ 226357371 NC_012526.1: 2779899 . . .2782016 1498 YP_002787111.1 1699 Deinococcus deserti VCD115 94984159complement(NC_008025.1: 1499 YP_603523.1 1700 Deinococcus 46701 . . .48812) geothermalis DSM 11300 15805114 complement(NC_001263.1: 1500NP_293799.1 1701 Deinococcus 69707 . . . 71875) radiodurans R1 89899079complement(NC_007908.1: 1501 YP_521550.1 1702 Rhodoferax 264127 . . .266178) ferrireducens T118 90422592 NC_007925.1: 1181422 . . . 11835721502 YP_530962.1 1703 Rhodopseudomonas palustris BisB18 90423512NC_007925.1: 2183340 . . . 2185475 1503 YP_531882.1 1704Rhodopseudomonas palustris BisB18 115525859 NC_008435.1: 4320999 . . .4323140 1504 YP_782770.1 1705 Rhodopseudomonas palustris BisA53167574473 complement(NZ_ABBG01000507.1: 1505 ZP_02367347.1 1706Burkholderia 7891 . . . 9969) oklahomensis C6786 83594327complement(NC_007643.1: 1506 YP_428079.1 1707 Rhodospirillum 3449832 . .. 3451943) rubrum ATCC 11170 90422165 NC_007925.1: 696325 . . . 6983881507 YP_530535.1 1708 Rhodopseudomonas palustris BisB18 34496985complement(NC_005085.1: 1508 NP_901200.1 1709 Chromobacterium 1636285 .. . 1638366) violaceum ATCC 12472 224825239complement(NZ_ACIS01000004.1: 1509 ZP_03698345.1 1710 Lutiella 398128 .. . 400215) nitroferrum 2002 148652157 complement(NC_009524.1: 1510YP_001279250.1 1711 Psychrobacter 415573 . . . 417720) sp. PRwf-193005047 complement(NC_007969.1: 1511 YP_579484.1 1712 Psychrobacter257926 . . . 260082) cryohalolentis K5 257453691 NZ_ACYI01000010.1: 1512ZP_05618978.1 1713 Enhydrobacter 16653 . . . 18797 aerosaccus SK60255321153 NZ_ACVR01000080.1: 1513 ZP_05362319.1 1714 Acinetobacter 44385. . . 46529 radioresistens SK82 50083778 complement(NC_005966.1: 1514YP_045288.1 1715 Acinetobacter 527524 . . . 529686) sp. ADP1 260549093NZ_GG704496.1: 86045 . . . 88189 1515 ZP_05823314.1 1716 Acinetobactersp. RUH2624 226953952 complement(NZ_ABYN01000201.1: 1516 ZP_03824416.11717 Acinetobacter 23157 . . . 25289) sp. ATCC 27244 153005955NC_009675.1: 3624676 . . . 3626811 1517 YP_001380280.1 1718Anaeromyxobacter sp. Fw109-5 86159318 complement(NC_007760.1: 1518YP_466103.1 1719 Anaeromyxobacter 3267950 . . . 3270094) dehalogenans2CP-C 52425053 complement(NC_006300.1: 1519 YP_088190.1 1720 Mannheimia977458 . . . 979596) succiniciproducens MBEL55E 152979320 NC_009655.1:1823344 . . . 1825485 1520 YP_001344949.1 1721 Actinobacillussuccinogenes 130Z 251792685 NC_012913.1: 968721 . . . 970856 1521YP_003007411.1 1722 Aggregatibacter aphrophilus NJ8700 145633066NZ_AAZF01000004.1: 1522 ZP_01788798.1 1723 Haemophilus 73469 . . . 75604influenzae 3655 113460945 complement(NC_008309.1: 1523 YP_719012.1 1724Haemophilus 873911 . . . 876049) somnus 129PT 15602570 NC_002663.1:821181 . . . 823319 1524 NP_245642.1 1725 Pasteurella multocida subsp.multocida str. Pm70 260913970 complement(NZ_ACZR01000013.1: 1525ZP_05920444.1 1726 Pasteurella 172766 . . . 174904) dagmatis ATCC 4332553729159 complement(NZ_AACK01000004.1: 1526 ZP_00133992.2 1727Actinobacillus 12180 . . . 14318) pleuropneumoniae serovar 1 str. 4074240949203 NZ_ACQL01000097.1: 1527 ZP_04753547.1 1728 Actinobacillus15931 . . . 18069 minor NM305 33152520 NC_002940.2: 1192390 . . .1194528 1528 NP_873873.1 1729 Haemophilus ducreyi 35000HP 254362832NZ_DS264681.1: 4949 . . . 7084 1529 ZP_04978908.1 1730 Mannheimiahaemolytica PHL213 219870647 NC_011852.1: 435431 . . . 437566 1530YP_002475022.1 1731 Haemophilus parasuis SH0165 258637834NZ_ACYJ01000022.1: 1531 ZP_05730581.1 1732 Pantoea sp. At- 41620 . . .43764 9b 188533336 complement(NC_010694.1: 1532 YP_001907133.1 1733Erwinia 1324250 . . . 1326379) tasmaniensis Et1/99 85059585 NC_007712.1:2759501 . . . 2761645 1533 YP_455287.1 1734 Sodalis glossinidius str.‘morsitans’ 258631105 complement(NZ_ACYK01000004.1: 1534 ZP_05723922.11735 Dickeya 104546 . . . 106687) dadantii Ech586 261820783complement(NC_013421.1: 1535 YP_003258889.1 1736 Pectobacterium 1606509. . . 1608647) wasabiae WPP163 242239978 NC_012880.1: 3004583 . . .3006724 1536 YP_002988159.1 1737 Dickeya dadantii Ech703 22125515complement(NC_004088.1: 1537 NP_668938.1 1738 Yersinia pestis 1788905 .. . 1791058) KIM 10 157371554 NC_009832.1: 3673293 . . . 3675482 1538YP_001479543.1 1739 Serratia proteamaculans 568 238920583 NC_012779.1:2589897 . . . 2592035 1539 YP_002934098.1 1740 Edwardsiella ictaluri93-146 197285630 NC_010554.1: 1898593 . . . 1900737 1540 YP_002151502.11741 Proteus mirabilis HI4320 37526984 NC_005126.1: 3612456 . . .3614597 1541 NP_930328.1 1742 Photorhabdus luminescens subsp. laumondiiTTO1 238895817 NC_012731.1: 3763302 . . . 3765449 1542 YP_002920553.11743 Klebsiella pneumoniae NTUH-K2044 146312483 NC_009436.1: 3080629 . .. 3082770 1543 YP_001177557.1 1744 Enterobacter sp. 638 260598715NC_013282.1: 3057676 . . . 3059814 1544 YP_003211286.1 1745 Cronobacterturicensis 601935 D21123.1: 77 . . . 2218 1545 BAA04663.1 1746Escherichia coli 238898722 complement(NC_012751.1: 1546 YP_002924403.11747 Candidatus 1494526 . . . 1496655) Hamiltonella defensa 5AT(Acyrthosiphon pisum) 227114079 NZ_ABVX01000029.1: 1547 ZP_03827735.11748 Pectobacterium 23117 . . . 25261 carotovorum subsp. brasiliensisPBR1692 89072717 complement(NZ_AAOU01000004.1: 1548 ZP_01159282.1 1749Photobacterium 98074 . . . 100221) sp. SKA34 54309953 NC_006370.1:3245262 . . . 3247418 1549 YP_130973.1 1750 Photobacterium profundum SS9262274670 NZ_ADAQ01000011.1: 1550 ZP_06052481.1 1751 Grimontia 496361 .. . 498520 hollisae CIP 101886 260768101 complement(NZ_ACZP01000013.1:1551 ZP_05877035.1 1752 Vibrio furnissii 239301 . . . 241427) CIP 102972260773044 NZ_ACZO01000006.1: 1552 ZP_05881960.1 1753 Vibrio 1066216 . .. 1068360 metschnikovii CIP 69.14 163802859complement(NZ_ABGR01000013.1: 1553 ZP_02196748.1 1754 Vibrio sp. 61871 .. . 64036) AND4 37680318 NC_005139.1: 2144915 . . . 2147059 1554NP_934927.1 1755 Vibrio vulnificus YJ016 149188151complement(NZ_ABCH01000004.1: 1555 ZP_01866446.1 1756 Vibrio shilonii163878 . . . 166022) AK1 218708991 complement(NC_011753.1: 1556YP_002416612.1 1757 Vibrio 1031606 . . . 1033810) splendidus LGP32209695557 NC_011312.1: 2262635 . . . 2264806 1557 YP_002263486.1 1758Aliivibrio salmonicida LFI1238 229525709 complement(NZ_ACHV01000001.1:1558 ZP_04415114.1 1759 Vibrio 2574339 . . . 2576483) cholerae bv.albensis VL426 145300284 NC_009348.1: 3681431 . . . 3683584 1559YP_001143125.1 1760 Aeromonas salmonicida subsp. salmonicida A449237807651 complement(NC_012691.1: 1560 YP_002892091.1 1761 Tolumonas958413 . . . 960569) auensis DSM 9187 90407162complement(NZ_AAPG01000006.1: 1561 ZP_01215350.1 1762 Psychromonas 41954. . . 44116) sp. CNPT3 119946918 NC_008709.1: 4084304 . . . 4086466 1562YP_944598.1 1763 Psychromonas ingrahamii 37 157374843complement(NC_009831.1: 1563 YP_001473443.1 1764 Shewanella 2041698 . .. 2043839) sediminis HAW-EB3 170727231 NC_010506.1: 3531467 . . .3533608 1564 YP_001761257.1 1765 Shewanella woodyi ATCC 51908 127513322NC_009092.1: 2807561 . . . 2809699 1565 YP_001094519.1 1766 Shewanellaloihica PV-4 167624517 NC_010334.1: 3149368 . . . 3151515 1566YP_001674811.1 1767 Shewanella halifaxensis HAW-EB4 117919999complement(NC_008577.1: 1567 YP_869191.1 1768 Shewanella sp. 1806421 . .. 1808574) ANA-3 119774631 complement(NC_008700.1: 1568 YP_927371.1 1769Shewanella 1807689 . . . 1809827) amazonensis SB2B 114563647NC_008345.1: 2956515 . . . 2958662 1569 YP_751160.1 1770 Shewanellafrigidimarina NCIMB 400 91793762 NC_007954.1: 2868611 . . . 2870791 1570YP_563413.1 1771 Shewanella denitrificans OS217 157376672 NC_009831.1:4313346 . . . 4315484 1571 YP_001475272.1 1772 Shewanella sediminisHAW-EB3 167624655 complement(NC_010334.1: 1572 YP_001674949.1 1773Shewanella 3320048 . . . 3322198) halifaxensis HAW-EB4 239996136complement(NZ_ABQB01000564.1: 1573 ZP_04716660.1 1774 Alteromonas 6079 .. . 8301) macleodii ATCC 27126 109898905 NC_008228.1: 3144369 . . .3146513 1574 YP_662160.1 1775 Pseudoalteromonas atlantica T6c 119469286NZ_AAVS01000006.1: 1575 ZP_01612225.1 1776 Alteromonadales 30053 . . .32206 bacterium TW-7 88860001 complement(NZ_AAOH01000005.1: 1576ZP_01134640.1 1777 Pseudoalteromonas 230650 . . . 232797) tunicata D271282469 NC_003910.7: 3309465 . . . 3311585 1577 YP_269873.1 1778Colwellia psychrerythraea 34H 152996332 NC_009654.1: 2608121 . . .2610220 1578 YP_001341167.1 1779 Marinomonas sp. MWYL1 87121463NZ_AANE01000011.1: 1579 ZP_01077352.1 1780 Marinomonas 112021 . . .114096 sp. MED121 146328905 NC_009446.1: 489780 . . . 491837 1580YP_001209362.1 1781 Dichelobacter nodosus VCS1703A 258544959NZ_ACKY01000059.1: 1581 ZP_05705193.1 1782 Cardiobacterium 4448 . . .6562 hominis ATCC 15826 262104765 complement(DS028152.1: 1582 EEY62817.11783 Phytophthora 677306 . . . 679621) infestans T30-4 262104764complement(DS028152.1: 1583 EEY62816.1 1784 Phytophthora 674496 . . .676781) infestans T30-4 159472743 XM_001694452.1: 258 . . . 2636 1584XP_001694504.1 1785 Chlamydomonas reinhardtii 168000833 XM_001753068.1:1 . . . 2367 1585 XP_001753120.1 1786 Physcomitrella patens subsp.Patens 172038009 complement(NC_010546.1: 1586 YP_001804510.1 1787Cyanothece sp. 3214848 . . . 3216944) ATCC 51142 126658068NZ_AAXW01000014.1: 1587 ZP_01729220.1 1788 Cyanothece sp. 79066 . . .81162 CCY0110 257060449 NC_013161.1: 2659296 . . . 2661419 1588YP_003138337.1 1789 Cyanothece sp. PCC 8802 218441705complement(NC_011729.1: 1589 YP_002380034.1 1790 Cyanothece sp. 5341705. . . 5343810) PCC 7424 166368837 NC_010296.1: 5646854 . . . 56489501590 YP_001661110.1 1791 Microcystis aeruginosa NIES-843 220909840NC_011884.1: 4551169 . . . 4553265 1591 YP_002485151.1 1792 Cyanothecesp. PCC 7425 16330299 NC_000911.1: 1250442 . . . 1252535 1592NP_441027.1 1793 Synechocystis sp. PCC 6803 86142732 NZ_AANC01000005.1:1593 ZP_01061171.1 1794 Leeuwenhoekiella 209172 . . . 211268 blandensisMED217 146301271 complement(NC_009441.1: 1594 YP_001195862.1 1795Flavobacterium 4208789 . . . 4210882) johnsoniae UW101 260061847NC_013222.1: 1408358 . . . 1410454 1595 YP_003194927.1 1796Robiginitalea biformata HTCC2501 88713711 complement(NZ_AAOC01000008.1:1596 ZP_01107792.1 1797 Flavobacteriales 22821 . . . 24917) bacteriumHTCC2170 86133149 complement(NZ_CH902588.1: 1597 ZP_01051731.1 1798Polaribacter sp. 146636 . . . 148729) MED152 88803680 NZ_AAOG01000005.1:1598 ZP_01119204.1 1799 Polaribacter 54861 . . . 56951 irgensii 23-P213962668 NZ_ABZV01000006.1: 1599 ZP_03390929.1 1800 Capnocytophaga103363 . . . 105438 sputigena ATCC 33612 256820698complement(NC_013162.1: 1600 YP_003141977.1 1801 Capnocytophaga 2243972. . . 2246047) ochracea DSM 7271 46581432 NC_002937.3: 3152216 . . .3154330 1601 YP_012240.1 1802 Desulfovibrio vulgaris str. Hildenborough218886955 NC_011769.1: 2286534 . . . 2288648 1602 YP_002436276.1 1803Desulfovibrio vulgaris str. ‘Miyazaki F’ 78358281 NC_007519.1: 3235663 .. . 3237822 1603 YP_389730.1 1804 Desulfovibrio desulfuricans subsp.desulfuricans str. G20 242280036 complement(NC_012881.1: 1604YP_002992165.1 1805 Desulfovibrio 2812652 . . . 2814769) salexigens DSM2638 258405159 complement(NC_013223.1: 1605 YP_003197901.1 1806Desulfohalobium 1218708 . . . 1220816) retbaense DSM 5692 256828849NC_013173.1: 1143375 . . . 1145477 1606 YP_003157577.1 1807Desulfomicrobium baculatum DSM 4028 225198782complement(NZ_ACJN01000010.1: 1607 ZP_03737911.1 1808Desulfonatronospira 60728 . . . 62824) thiodismutans ASO3-1 242278203NC_012881.1: 802309 . . . 804414 1608 YP_002990332.1 1809 Desulfovibriosalexigens DSM 2638 212704109 complement(NZ_ABXU01000065.1: 1609ZP_03312237.1 1810 Desulfovibrio 34368 . . . 36470) piger ATCC 29098220903578 complement(NC_011883.1: 1610 YP_002478890.1 1811 Desulfovibrio357004 . . . 359112) desulfuricans subsp. desulfuricans str. ATCC 2777451244410 NC_006138.1: 608983 . . . 611115 1611 YP_064294.1 1812Desulfotalea psychrophila LSv54 94986723 NC_008011.1: 347892 . . .350012 1612 YP_594656.1 1813 Lawsonia intracellularis PHE/MN1-00119488858 complement(NZ_AAVU01000021.1: 1613 ZP_01621820.1 1814 Lyngbyasp. 33384 . . . 35414) PCC 8106 209524350 NZ_ABYK01000010.1: 1614ZP_03272899.1 1815 Arthrospira 35808 . . . 37916 maxima CS- 328116748909 NC_008554.1: 1826816 . . . 1828915 1615 YP_845596.1 1816Syntrophobacter fumaroxidans MPOB 241776655 NZ_ACQQ01000008.1: 1616ZP_04773932.1 1817 Allochromatium 86078 . . . 88198 vinosum DSM 18032476008 NC_005027.1: 5198833 . . . 5200932 1617 NP_869002.1 1818Rhodopirellula baltica SH 1 78776256 NC_007575.1: 60204 . . . 62282 1618YP_392571.1 1819 Sulfurimonas denitrificans DSM 1251 254458291complement(NZ_DS995288.1: 1619 ZP_05071717.1 1820 Campylobacterales173480 . . . 175561) bacterium GD 1 229532518 NZ_ABUV01000006.1: 1620ZP_04421899.1 1821 Sulfurospirillum 73569 . . . 75677 deleyianum DSM6946 152993574 NC_009663.1: 2069625 . . . 2071724 1621 YP_001359295.11822 Sulfurovum sp. NBC37-1 120401715 NC_008726.1: 740616 . . . 7426941622 YP_951544.1 1823 Mycobacterium vanbaalenii PYR-1 145220810complement(NC_009338.1: 1623 YP_001131488.1 1824 Mycobacterium 189392 .. . 191515) gilvum PYR-GCK 108797517 NC_008146.1: 594117 . . . 5962311624 YP_637714.1 1825 Mycobacterium sp. MCS 118473540 NC_008596.1:867578 . . . 869656 1625 YP_885188.1 1826 Mycobacterium smegmatis str.MC2 155 169631304 complement(NC_010397.1: 1626 YP_001704953.1 1827Mycobacterium 4294451 . . . 4296532) abscessus 240168870NZ_ACBV01000011.1: 1627 ZP_04747529.1 1828 Mycobacterium 33884 . . .35974 kansasii ATCC 12478 183980733 NC_010612.1: 853987 . . . 8560711628 YP_001849024.1 1829 Mycobacterium marinum M 15607549 NC_000962.2:491786 . . . 493858 1629 NP_214922.1 1830 Mycobacterium tuberculosisH37Rv 41409983 NC_002944.2: 4345845 . . . 4347932 1630 NP_962819.1 1831Mycobacterium avium subsp. paratuberculosis K-10 254818871complement(NZ_ABIN01000026.1: 1631 ZP_05223872.1 1832 Mycobacterium 2280. . . 4439) intracellulare ATCC 13950 226304961 NC_012490.1: 1605870 . .. 1607948 1632 YP_002764919.1 1833 Rhodococcus erythropolis PR4111019190 complement(NC_008268.1: 1633 YP_702162.1 1834 Rhodococcus2308925 . . . 2311045) jostii RHA1 54027320 complement(NC_006361.1: 1634YP_121562.1 1835 Nocardia 5652808 . . . 5654895) farcinica IFM 10152227978095 NZ_ABVA01000001.1: 1635 ZP_04025361.1 1836 Tsukamurella 785441. . . 787570 paurometabola DSM 20162 262204223 complement(NC_013441.1:1636 YP_003275431.1 1837 Gordonia 4704088 . . . 4706208) bronchialis DSM43247 256831883 complement(NC_013174.1: 1637 YP_003160610.1 1838 Jonesia683848 . . . 685947) denitrificans DSM 20603 260517199complement(NZ_ABUN01000002.1: 1638 ZP_05816650.1 1839 Sanguibacter 90744. . . 92939) keddieii DSM 10542 229243856 complement(NZ_ABTJ01000131.1:1639 ZP_04368027.1 1840 Cellulomonas 4381 . . . 6468) flavigena DSM20109 229821528 NC_012669.1: 3401218 . . . 3403323 1640 YP_002883054.11841 Beutenbergia cavernae DSM 12333 227428424complement(NZ_ABVC01000008.1: 1641 ZP_03911481.1 1842 Xylanimonas 150308. . . 152407) cellulosilytica DSM 15894 119717178complement(NC_008699.1: 1642 YP_924143.1 1843 Nocardioides 3139954 . . .3142044) sp. JS614 227381337 complement(NZ_ABUC01000011.1: 1643ZP_03864789.1 1844 Kribbella 233655 . . . 235784) flavida DSM 1783688856399 NZ_AAOB01000010.1: 1644 ZP_01131057.1 1845 marine 2970 . . .5138 actinobacterium PHSC20C1 170780609 NC_010407.1: 179995 . . . 1821121645 YP_001708941.1 1846 Clavibacter michiganensis subsp. Sepedonicus50954174 NC_006087.1: 335128 . . . 337257 1646 YP_061462.1 1847Leifsonia xyli subsp. xyli str. CTCB07 114331961 complement(NC_008344.1:1647 YP_748183.1 1848 Nitrosomonas 2107910 . . . 2110039) eutropha C91256395328 complement(NC_013131.1: 1648 YP_003116892.1 1849 Catenulispora7130890 . . . 7133034) acidiphila DSM 44928 258650827 NC_013235.1:639398 . . . 641491 1649 YP_003199983.1 1850 Nakamurella multipartitaDSM 44233 257068066 complement(NC_013172.1: 1650 YP_003154321.1 1851Brachybacterium 995592 . . . 997667) faecium DSM 4810 227497260complement(NZ_ACFH01000109.1: 1651 ZP_03927492.1 1852 Actinomyces 3054 .. . 5108) urogenitalis DSM 15434 256824971 NC_013169.1: 1149994 . . .1152081 1652 YP_003148931.1 1853 Kytococcus sedentarius DSM 20547260455562 NZ_ACZH01000022.1: 1653 ZP_05803950.1 1854 Streptomyces 9845 .. . 11917 flavogriseus ATCC 33331 182435904 NC_010572.1: 2506931 . . .2509012 1654 YP_001823623.1 1855 Streptomyces griseus subsp. griseusNBRC 13350 254387454 NZ_DS570624.1: 26512 . . . 28596 1655 ZP_05002693.11856 Streptomyces clavuligerus ATCC 27064 254400535 NZ_DS570905.1:178100 . . . 180199 1656 ZP_05015493.1 1857 Streptomyces sviceus ATCC29083 256813645 NZ_ACFA01000303.1: 1657 ZP_05538660.1 1858 Streptomyces9482 . . . 11584 griseoflavus Tu4000 239928836 NZ_ABYA01000185.1: 1658ZP_04685789.1 1859 Streptomyces 2180 . . . 4282 ghanaensis ATCC 14672256804684 complement(NZ_ACEZ01000169.1: 1659 ZP_05534308.1 1860Streptomyces 8822 . . . 10924) viridochromogenes DSM 40736 256785123NZ_ACEY01000098.1: 1660 ZP_05523554.1 1861 Streptomyces 97187 . . .99280 lividans TK24 29829365 NC_003155.4: 3467325 . . . 3469415 1661NP_823999.1 1862 Streptomyces avermitilis MA-4680 260646824 FN554889.1:3224239 . . . 3226344 1662 CBG69921.1 1863 Streptomyces scabiei 87.22239982381 complement(NZ_ABYC01000362.1: 1663 ZP_04704905.1 1864Streptomyces 40088 . . . 42163) albus J1074 254382385complement(NZ_DS570390.1: 1664 ZP_04997745.1 1865 Streptomyces 111950 .. . 114034) sp. Mg1 256769973 complement(NZ_ACEW01000403.1: 1665ZP_05509147.1 1866 Streptomyces 16454 . . . 18541) sp. C 256776255NZ_ACEX01000277.1: 1666 ZP_05514718.1 1867 Streptomyces 2545 . . . 4641hygroscopicus ATCC 53653 254378850 NZ_DS570550.1: 40417 . . . 42507 1667ZP_04994290.1 1868 Streptomyces sp. SPB74 229854086complement(NZ_ABUU01000066.1: 1668 ZP_04474082.1 1869 Streptosporangium39364 . . . 41415) roseum DSM 43021 145596204 NC_009380.1: 4234932 . . .4237007 1669 YP_001160501.1 1870 Salinispora tropica CNB- 440 159039600NC_009953.1: 4631907 . . . 4633976 1670 YP_001538853.1 1871 Salinisporaarenicola CNS- 205 238060866 NZ_GG657738.1: 2330097 . . . 2332163 1671ZP_04605575.1 1872 Micromonospora sp. ATCC 39149 116671783complement(NC_008541.1: 1672 YP_832716.1 1873 Arthrobacter 3648900 . . .3651011) sp. FB24 148807608 complement(EF601880.1: 1673 ABR13603.1 1874Arthrobacter 72 . . . 2150) oxydans 239916738 complement(NC_012803.1:1674 YP_002956296.1 1875 Micrococcus 190981 . . . 193056) luteus NCTC2665 255326162 NZ_ACVO01000004.1: 1675 ZP_05367249.1 1876 Rothia 127571. . . 129661 mucilaginosa ATCC 25296 184199797 complement(NC_010617.1:1676 YP_001854004.1 1877 Kocuria 164688 . . . 166781) rhizophila DC2201254368446 NZ_DS264133.1: 69966 . . . 72062 1677 ZP_04984463.1 1878Francisella tularensis subsp. holarctica FSC022 167626922complement(NC_010336.1: 1678 YP_001677422.1 1879 Francisella 741506 . .. 743602) philomiragia subsp. philomiragia ATCC 25017 94676965NC_007984.1: 392877 . . . 395012 1679 YP_588827.1 1880 Baumanniacicadellinicola str. Hc (Homalodisca coagulata) P57273 BA000003.2:189582 . . . 191708 1680 NP_240007.1 1881 Buchnera aphidicola str. APS(Acyrthosiphon pisum) 254444018 NZ_DS990592.1: 1298899 . . . 13010101681 ZP_05057494.1 1882 Verrucomicrobiae bacterium DG1235 171914782NZ_ABIZ01000001.1: 1682 ZP_02930252.1 1883 Verrucomicrobium 6593044 . .. 6595128 spinosum DSM 4136 114777389 NZ_AATS01000006.1: 1683ZP_01452386.1 1884 Mariprofundus 50467 . . . 52602 ferrooxydans PV-194500866 NZ_AAQH01000011.1: 1684 ZP_01307392.1 1885 Bermanella 33324 . .. 35456 marisrubri

In other embodiments, a polynucleotide, gene and/or polypeptide encodingphosphotransacetylase can have at least about 70% to about 75%, about80% to about 85%, about 85% to about 90%, about 90% to about 95%, about96%, about 97%, about 98%, or about 99% sequence identity to any one ofthe sequences of Tables 10 or 12a or 12b, wherein the polynucleotide,gene and/or polypeptide encodes a polypeptide havingphosphotransacetylase activity.

In embodiments, a polynucleotide, gene and/or polypeptide encodingphosphotransacetylase corresponds to the Enzyme Commission Number EC2.3.1.8.

In other embodiments, the phosphotransacetylase polynucleotide, geneand/or polypeptide sequences described herein or those recited in theart can be used to identify phosphotransacetylase sequences orphosphotransacetylase homologs in other cells, as described above forPDC.

Methods for gene expression in recombinant host cells, including, butnot limited to, yeast cells are known in the art (see, for example,Methods in Enzymology, Volume 194, Guide to Yeast Genetics and Molecularand Cell Biology (Part A, 2004, Christine Guthrie and Gerald R. Fink(Eds.), Elsevier Academic Press, San Diego, Calif.). In embodiments, thecoding region for the phosphoketolase and/or phosphotransacetylase genesto be expressed can be codon optimized for the target host cell, as wellknown to one skilled in the art. Expression of genes in recombinant hostcells, including but not limited to yeast cells, can require a promoteroperably linked to a coding region of interest, and a transcriptionalterminator. A number of promoters can be used in constructing expressioncassettes for genes, including, but not limited to, the followingconstitutive promoters suitable for use in yeast: FBA1, TDH3 (GPD),ADH1, and GPM1; and the following inducible promoters suitable for usein yeast: GAL1, GAL10 and CUP1. Other yeast promoters include hybridpromoters UAS(PGK1)-FBA1p (SEQ ID NO: 1893), UAS(PGK1)-ENO2p (SEQ ID NO:1894), UAS(FBA1)-PDC1p (SEQ ID NO: 1895), UAS(PGK1)-PDC1p (SEQ ID NO:1896), and UAS(PGK)-OLE1p (SEQ ID NO: 1897). Suitable transcriptionalterminators that can be used in a chimeric gene construct for expressioninclude, but are not limited to, FBA1t, TDH3t, GPM1t, ERG10t, GAL1t,CYC1t, and ADH1t.

Recombinant polynucleotides are typically cloned for expression usingthe coding sequence as part of a chimeric gene used for transformation,which includes a promoter operably linked to the coding sequence as wellas a ribosome binding site and a termination control region. The codingregion may be from the host cell for transformation and combined withregulatory sequences that are not native to the natural gene encodingphosphoketolase and/or phosphotransacetylase. Alternatively, the codingregion may be from another host cell.

Vectors useful for the transformation of a variety of host cells arecommon and described in the literature. Typically the vector contains aselectable marker and sequences allowing autonomous replication orchromosomal integration in the desired host. In addition, suitablevectors can comprise a promoter region which harbors transcriptionalinitiation controls and a transcriptional termination control region,between which a coding region DNA fragment may be inserted, to provideexpression of the inserted coding region. Both control regions can bederived from genes homologous to the transformed host cell, although itis to be understood that such control regions can also be derived fromgenes that are not native to the specific species chosen as a productionhost.

In embodiments, suitable promoters, transcriptional terminators, andphosphoketolase and/or phosphotransacetylase coding regions can becloned into E. coli-yeast shuttle vectors, and transformed into yeastcells. Such vectors allow strain propagation in both E. coli and yeaststrains, and can contain a selectable marker and sequences allowingautonomous replication or chromosomal integration in the desired host.Typically used plasmids in yeast include, but are not limited to,shuttle vectors pRS423, pRS424, pRS425, and pRS426 (American TypeCulture Collection, Rockville, Md.), which contain an E. colireplication origin (e.g., pMB1), a yeast 2-micron origin of replication,and a marker for nutritional selection. The selection markers for thesefour vectors are HIS3 (vector pRS423), TRP1 (vector pRS424), LEU2(vector pRS425) and URA3 (vector pRS426).

In embodiments, construction of expression vectors with a chimeric geneencoding the described phosphoketolases and/or phosphotransacetylasescan be performed by the gap repair recombination method in yeast. Inembodiments, a yeast vector DNA is digested (e.g., in its multiplecloning site) to create a “gap” in its sequence. A number of insert DNAsof interest are generated that contain an approximately 21 bp sequenceat both the 5′ and the 3′ ends that sequentially overlap with eachother, and with the 5′ and 3′ terminus of the vector DNA. For example,to construct a yeast expression vector for “Gene X,” a yeast promoterand a yeast terminator are selected for the expression cassette. Thepromoter and terminator are amplified from the yeast genomic DNA, andGene X is either PCR amplified from its source organism or obtained froma cloning vector comprising Gene X sequence. There is at least a 21 bpoverlapping sequence between the 5′ end of the linearized vector and thepromoter sequence, between the promoter and Gene X, between Gene X andthe terminator sequence, and between the terminator and the 3′ end ofthe linearized vector. The “gapped” vector and the insert DNAs are thenco-transformed into a yeast strain and plated on the medium containingthe appropriate compound mixtures that allow complementation of thenutritional selection markers on the plasmids. The presence of correctinsert combinations can be confirmed by PCR mapping using plasmid DNAprepared from the selected cells. The plasmid DNA isolated from yeast(usually low in concentration) can then be transformed into an E. colistrain, e.g. TOP10, followed by mini preps and restriction mapping tofurther verify the plasmid construct. Finally the construct can beverified by sequence analysis.

Like the gap repair technique, integration into the yeast genome alsotakes advantage of the homologous recombination system in yeast. Inembodiments, a cassette containing a coding region plus control elements(promoter and terminator) and auxotrophic marker is PCR-amplified with ahigh-fidelity DNA polymerase using primers that hybridize to thecassette and contain 40-70 base pairs of sequence homology to theregions 5′ and 3′ of the genomic area where insertion is desired. ThePCR product is then transformed into yeast and plated on mediumcontaining the appropriate compound mixtures that allow selection forthe integrated auxotrophic marker. For example, to integrate “Gene X”into chromosomal location “Y”, the promoter-coding region X-terminatorconstruct is PCR amplified from a plasmid DNA construct and joined to anautotrophic marker (such as URA3) by either SOE PCR or by commonrestriction digests and cloning. The full cassette, containing thepromoter-coding regionX-terminator-URA3 region, is PCR amplified withprimer sequences that contain 40-70 bp of homology to the regions 5′ and3′ of location “Y” on the yeast chromosome. The PCR product istransformed into yeast and selected on growth media lacking uracil.Transformants can be verified either by colony PCR or by directsequencing of chromosomal DNA.

The presence of phosphoketolase and phosphotransacetylase activity inthe recombinant host cells disclosed herein can be confirmed usingroutine methods known in the art. In a non-limiting example, and asdescribed in the Examples herein, transformants can be screened by PCRusing primers for the phosphoketolase and phosphotransacetylase genes.In embodiments, and as described in the Examples herein, transformantscan be screened by PCR with primers N1039 and N1040 (SEQ ID NOs: 639 and640) to confirm integration of the xpk1 gene, and primers N1041 andN1042 (SEQ ID NOs: 641 and 642) can be used to confirm integration ofthe eutD gene. In another non-limiting example, and as described in theExamples herein, transformants can be screened for integration ofphosphoketolase constructs and/or phosphotransacetylase constructs atthe Δpdc1::ilvD(Sm) locus by the loss of ilvD(Sm) in the host cells.

In another non-limiting example, and as described in the examplesherein, phosphoketolase activity can be assayed by expressingphosphoketolase identifiable by the methods disclosed herein in arecombinant host cell disclosed herein that lacks endogenousphosphoketolase activity. If phosphoketolase activity is present, suchcells exhibit a reduced or eliminated requirement for exogenoustwo-carbon substrate supplementation for growth in culture.

In another non-limiting example, and as described in the examplesherein, phosphoketolase and phosphotransacetylase activity can beassayed by expressing phosphoketolase and phosphotransacetylase activityidentifiable by the methods disclosed herein in a recombinant host celldisclosed herein that lacks endogenous phosphoketolase andphosphotransacetylase activity. If phosphoketolase activity andphosphoketolase activity are present, such cells exhibit a reduced oreliminated requirement for exogenous two-carbon substratesupplementation for growth in culture.

In another non-limiting example, phosphoketolase and/orphosphotransacetylase activity can be confirmed by more indirectmethods, such as by assaying for a downstream product in a pathwayrequiring phosphoketolase activity. For example, a polypeptide havingphosphoketolase activity can catalyze the conversion ofxylulose-5-phosphate into glyceraldehyde-3-phosphate andacetyl-phosphate and/or the conversion of fructose-6-phosphate intoerythrose-4-phosphate and acetyl-phosphate. Also, a polypeptide havingphosphotransacetylase activity can catalyze the conversion ofacetyl-phosphate into acetyl-CoA.

Suitable Pathway Carbon Substrates and Exogenous Two-Carbon SubstrateSupplementation

PDC-KO cells fail to grow in glucose-containing media (e.g., 2%glucose), but PDC-KO cells carrying a functional butanediol biosyntheticpathway have been shown to grow on glucose supplemented with exogenoustwo-carbon substrates such as ethanol (see for example, US PatentApplication Publication No. 20090305363, herein incorporated byreference). In embodiments, the host cells disclosed herein can be grownin fermentation media which contains a suitable pathway carbon substrateand two-substrate supplement, including combinations of suitable pathwaycarbon substrates with C2-substrate supplement. Non-limiting examples ofsuitable pathway carbon substrates include, but are not limited to,monosaccharides such as fructose, oligosaccharides such as lactosemaltose, galactose, or sucrose, polysaccharides such as starch orcellulose or mixtures thereof and unpurified mixtures from renewablefeedstocks such as cheese whey permeate, cornsteep liquor, sugar beetmolasses, and barley malt, including any combinations thereof. In otherembodiments, the suitable pathway carbon substrates can include lactate,glycerol, or combinations thereof.

In embodiments, a suitable carbon substrate can be a one-carbonsubstrate such as carbon dioxide, or methanol for which metabolicconversion into key biochemical intermediates has been demonstrated, orcombinations thereof. In other embodiments related to methylotrophicorganisms, the carbon substrate can be carbon containing compounds suchas methylamine, glucosamine and a variety of amino acids for metabolicactivity. In a non-limiting example, methylotrophic yeasts are known toutilize the carbon from methylamine to form trehalose or glycerol(Bellion et al., Microb. Growth C1 Compd., [Int. Symp.], 7th (1993),415-32, Editor(s): Murrell, J. Collin; Kelly, Don P. Publisher:Intercept, Andover, UK). In another non-limiting example, variousspecies of Candida can metabolize alanine (Sulter et al., Arch.Microbiol. 153:485-489 (1990)). Hence it is contemplated that the sourceof carbon utilized in the present invention can encompass a wide varietyof carbon containing substrates and will only be limited by the choiceof organism.

In other embodiments, the suitable pathway carbon substrate can beglucose, fructose, and sucrose, or mixtures of these with five-carbon(C5) sugars such as xylose and/or arabinose for yeasts cells modified touse C5 sugars. In embodiments, sucrose can be derived from renewablesugar sources such as sugar cane, sugar beets, cassava, sweet sorghum,and mixtures thereof. In other embodiment, glucose and dextrose canderived from renewable grain sources through saccharification of starchbased feedstocks including grains such as corn, wheat, rye, barley,oats, and mixtures thereof. In embodiments, the pathway carbonsubstrates can be derived from renewable cellulosic or lignocellulosicbiomass through processes of pretreatment and saccharification, asdescribed, for example, in U.S. Patent Application Publication No. US20070031918 A1, which is herein incorporated by reference.

As used herein, “biomass” refers to any cellulosic or lignocellulosicmaterial and includes, but is not limited to, materials comprisingcellulose, and optionally further comprising hemicellulose, lignin,starch, oligosaccharides and/or monosaccharides. In embodiments, biomasscan also comprise additional components, such as protein and/or lipid.In other embodiments, biomass can be derived from a single source, orbiomass can comprise a mixture derived from more than one source; forexample, biomass can comprise a mixture of corn cobs and corn stover, ora mixture of grass and leaves. Biomass includes, but is not limited to,bioenergy crops, agricultural residues, municipal solid waste,industrial solid waste, sludge from paper manufacture, yard waste, woodand forestry waste. Other non-limiting examples of biomass include, butare not limited to, corn grain, corn cobs, crop residues such as cornhusks, corn stover, grasses, wheat, wheat straw, barley, barley straw,hay, rice straw, switchgrass, waste paper, sugar cane bagasse, sorghum,soy, components obtained from milling of grains, trees, branches, roots,leaves, wood chips, sawdust, shrubs and bushes, vegetables, fruits,flowers, animal manure, and mixtures thereof.

The recombinant host cells described herein can be cultured usingstandard laboratory techniques known in the art (see, e.g., Methods inYeast Genetics, 2005, Cold Spring Harbor Laboratory Press, Cold SpringHarbor, N.Y., pp. 201-202). In embodiments related to media supplementedwith exogenous two-carbon substrates, and as described in the Examples,recombinant host cells can be grown in synthetic complete mediumsupplemented with one or more exogenous two-carbon substrates asdescribed herein at a concentration of about 0.01%, about 0.05%, about0.1%, about 0.5%, about 1.0%, about 1.5%, about 1.5% or about 2% (v/v)of the media. In embodiments, the recombinant host cells can be grown insynthetic complete culture without uracil or histidine, supplementedwith 0.5% (v/v) ethanol. In embodiments related to growth in media thatis not supplemented with exogenous two-carbon substrates, therecombinant host cells described herein can be first grown in culturemedium comprising an exogenous two-carbon substrate and then diluted(e.g., starting OD=0.1, 20 ml medium in a 125 ml vented flask) intomedia that is not supplemented with exogenous two-carbon substrate.

The growth of the recombinant host cells described herein can bemeasured by methods known in the art (see, e.g., Methods in YeastGenetics, 2005, Cold Spring Harbor Laboratory Press, Cold Spring Harbor,N.Y., pp. 201-202). In a non-limiting example, the growth of therecombinant host cells described herein can be determined by measuringthe optical density (OD) of cell cultures over time. For example, the ODat 600 nm for a yeast culture is proportional to yeast cell number. Inanother non-limiting example, the growth of the recombinant host cellsdescribed herein can be determined by counting viable cells in a sampleof the culture over time.

Applicants have provided cells that have a reduced or eliminatedrequirement for two-carbon substrate supplementation for growth. Inembodiments, such cells comprise (i) a deletion, mutation, and/orsubstitution in an endogenous gene encoding a polypeptide that convertspyruvate to acetaldehyde, acetyl-phosphate or acetyl-CoA that results ina requirement for exogenous two-carbon substrate supplementation foroptimal growth; (ii) a heterologous polynucleotide encoding apolypeptide having phosphoketolase activity; and optionally (iii) aheterologous polynucleotide encoding a polypeptide havingphosphotransacetylase activity. In embodiments, such cells comprise (i)a modification in an endogenous polypeptide having PDC activity whichresults in reduced or eliminated PDC activity; (ii) a heterologouspolynucleotide encoding a polypeptide having phosphoketolase activity;and optionally (iii) a heterologous polynucleotide encoding apolypeptide having phosphotransacetylase activity. As such, Applicantshave also provided methods of improving the growth of a recombinant hostcell comprising at least one modification in an endogenous polypeptidethat converts pyruvate to acetaldehyde, acetyl-phosphate or acetyl-CoAthat results in a requirement for exogenous two-carbon substratesupplementation for optimal growth comprising transforming the host cellwith a heterologous polynucleotide encoding a polypeptide havingphosphoketolase activity. Applicants have also provided methods ofimproving the growth of a recombinant host cell comprising at least onemodification in an endogenous polypeptide having pyruvate decarboxylaseactivity (e.g., having at least one deletion, mutation or substitutionin an endogenous gene encoding a polypeptide having PDC activity thatresults in reduced or eliminated PDC activity) comprising transformingthe host cell with a heterologous polynucleotide encoding a polypeptidehaving phosphoketolase activity. In other embodiments, the methodfurther comprises transforming a recombinant host cell described hereinwith a heterologous polynucleotide encoding a polypeptide havingphosphotransacetylase activity.

Applicants have also provided methods of reducing or eliminating therequirement for an exogenous two-carbon substrate for the growth of arecombinant host cell comprising at least one modification in anendogenous activity that converts pyruvate to acetaldehyde,acetyl-phosphate or acetyl-CoA that results in a requirement forexogenous two-carbon substrate supplementation for optimal growthcomprising transforming the host cell with a heterologous polynucleotideencoding a polypeptide having phosphoketolase activity comprisingtransforming the recombinant host cell with a heterologouspolynucleotide encoding a polypeptide having phosphoketolase activity.In other embodiments, the method further comprises transforming therecombinant host cell with a heterologous polynucleotide encoding apolypeptide having phosphotransacetylase activity.

Applicants have also provided methods of reducing the requirement for anexogenous two-carbon substrate for the growth of a recombinant host cellcomprising at least one modification in an endogenous polypeptide havingPDC activity (e.g., having at least one deletion, mutation orsubstitution in an endogenous gene encoding a polypeptide havingpyruvate decarboxylase activity) comprising transforming the recombinanthost cell with a heterologous polynucleotide encoding a polypeptidehaving phosphoketolase activity. In other embodiments, the methodfurther comprises transforming the recombinant host cell with aheterologous polynucleotide encoding a polypeptide havingphosphotransacetylase activity.

In addition, Applicants have provided methods of eliminating therequirement for an exogenous two-carbon substrate for the growth of arecombinant host cell comprising at least one modification in anendogenous polypeptide having PDC activity (e.g., having at least onedeletion, mutation or substitution in an endogenous gene encoding apolypeptide having PDC activity that results in reduced or eliminatedPDC activity) comprising transforming the recombinant host cell with aheterologous polynucleotide encoding a polypeptide havingphosphoketolase activity. In other embodiments, the method furthercomprises transforming the recombinant host cell with a heterologouspolynucleotide encoding a polypeptide having phosphotransacetylaseactivity.

In embodiments, a reduced requirement for exogenous two-carbon substratesupplementation can be a growth rate of the recombinant host cellsdescribed herein in media that is not supplemented with an exogenoustwo-carbon substrate that is the same or substantially equivalent to thegrowth rate of a recombinant host cell comprising a modification in anendogenous activity that converts pyruvate to acetaldehyde,acetyl-phosphate or acetyl-CoA grown in media that is supplemented withan exogenous two-carbon substrate. In embodiments, such a growth ratecan be at least about 70%, at least about 75%, at least about 80%, atleast about 85%, at least about 90%, at least about 95%, at least about96%, at least about 97%, at least about 98%, or at least about 99% ofthe growth rate of a recombinant host cell comprising a modification inan endogenous activity that converts pyruvate to acetaldehyde,acetyl-phosphate or acetyl-CoA grown in media that is supplemented withan exogenous two-carbon substrate.

In embodiments, a reduced requirement for exogenous two-carbon substratesupplementation can be a growth rate of the recombinant host cellsdescribed herein in media that is not supplemented with an exogenoustwo-carbon substrate that is the same or substantially equivalent to thegrowth rate of a recombinant host cell comprising a modification in anendogenous PDC activity grown in media that is supplemented with anexogenous two-carbon substrate. In embodiments, such a growth rate canbe at least about 70%, at least about 75%, at least about 80%, at leastabout 85%, at least about 90%, at least about 95%, at least about 96%,at least about 97%, at least about 98%, or at least about 99% of thegrowth rate of a recombinant host cell comprising a modification in anendogenous PDC activity grown in media that is supplemented with anexogenous two-carbon substrate.

In other embodiments, the recombinant host cells described herein have agrowth rate in media that is not supplemented with an exogenoustwo-carbon substrate that is greater than the growth rate of arecombinant host cell comprising a modification in an endogenousactivity that converts pyruvate to acetaldehyde, acetyl-phosphate oracetyl-CoA in media that is not supplemented with an exogenoustwo-carbon substrate.

In other embodiments, the recombinant host cells described herein have agrowth rate in media that is not supplemented with an exogenoustwo-carbon substrate that is greater than the growth rate of arecombinant host cell comprising a modification in an endogenous PDCactivity in media that is not supplemented with an exogenous two-carbonsubstrate.

In other embodiments, the recombinant host cells described herein canhave an increased glucose consumption compared to a recombinant hostcell comprising a modification in an endogenous polypeptide thatconverts pyruvate to acetaldehyde, acetyl-phosphate or acetyl-CoA.

In other embodiments, the recombinant host cells described herein canhave an increased glucose consumption compared to a recombinant hostcell comprising a modification in an endogenous polypeptide having PDCactivity (e.g., at least one deletion, mutation, and/or substitution inan endogenous gene encoding a polypeptide having PDC activity thatreduces or eliminates PDC activity).

Glucose consumption of the recombinant host cells described herein canbe measured by methods known in the art (see, e.g., Methods in YeastGenetics, 2005, Cold Spring Harbor Laboratory Press, Cold Spring Harbor,N.Y., pp. 201-202). In a non-limiting example, glucose consumption canbe measured by quantitating the amount of glucose in culture media byHPLC or with a YSI Biochemistry Analyzer (YSI, Inc., Yellow Springs,Ohio).

In other embodiments, methods of producing a recombinant host cell areprovided comprising transforming a recombinant host cell comprising amodification in an endogenous polynucleotide, gene or polypeptideencoding pyruvate decarboxylase (e.g., at least one deletion, mutation,and/or substitution in an endogenous gene encoding a polypeptide havingpyruvate decarboxylase activity) with a heterologous polynucleotideencoding a polypeptide having phosphoketolase activity. In otherembodiments, the method further comprises transforming the recombinanthost cell with a heterologous polynucleotide encoding a polypeptidehaving phosphotransacetylase activity.

In other embodiments, methods for the conversion of xylulose 5-phosphateor fructose 6-phosphate into acetyl-phosphate are provided comprising(i) providing a recombinant host cell as described herein, orcombinations thereof; and (ii) growing the recombinant host cell underconditions wherein xylulose 5-phosphate or fructose-6-phosphate isconverted into acetyl-phosphate. In other embodiments, methods for theconversion of xylulose 5-phosphate or fructose-6-phosphate intoacetyl-CoA are provided comprising (i) providing a recombinant host cellas described herein, or combinations thereof; and (ii) growing therecombinant host cell under conditions where xylulose 5-phosphate orfructose-6-phosphate is converted into acetyl-CoA.

In other embodiments, methods for the conversion of acetyl-phosphate toacetyl-CoA are provided comprising (i) providing a recombinant host cellas described herein, or combinations thereof; and (ii) growing therecombinant host cell under conditions where acetyl-phosphate isconverted into acetyl-CoA. In other embodiments, methods for increasingthe specific activity of a heterologous polypeptide havingphosphoketolase activity in a recombinant host cell are providedcomprising (i) providing a recombinant host cell as described herein, orcombinations thereof; and (ii) growing the recombinant host cell underconditions wherein the heterologous polypeptide having phosphoketolaseactivity is expressed in functional form having a specific activitygreater than the same recombinant host cell lacking the heterologouspolypeptide having phosphoketolase activity.

In other embodiments, methods for increasing the specific activity of aheterologous polypeptide having phosphotransacetylase activity in arecombinant host cell are provided comprising (i) providing arecombinant host cell described herein, or combinations thereof; and(ii) growing the recombinant host cell under conditions whereby theheterologous polypeptide having phosphotransacetylase activity isexpressed in functional form having a specific activity greater than thesame recombinant host cell lacking a heterologous polypeptide havingphosphotransacetylase activity.

In still other embodiments, methods for increasing the activity of thephosphoketolase pathway in a recombinant host cell are providedcomprising (i) providing a recombinant host cell as described herein, orcombinations thereof; and (ii) growing the host cell under conditionswhereby the activity of the phosphoketolase pathway in the host cell isincreased.

Threonine aldolase (E.C. number 4.1.2.5) catalyzes cleavage of threonineto produce glycine and acetaldehyde. Plasmid-based overexpression of agene encoding this enzyme in S. cerevisiae PDC-KO strains was shown toeliminate the requirement for exogenous C2 supplementation (van Maris etal, Appl Environ Microbiol. 2003 April; 69(4):2094-9). In embodiments,recombinant host cells comprise (i) a deletion, mutation, and/orsubstitution in an endogenous gene encoding a polypeptide that convertspyruvate to acetaldehyde, acetyl-phosphate or acetyl-CoA that results ina requirement for exogenous two-carbon substrate supplementation foroptimal growth; and (ii) a heterologous polynucleotide encoding apolypeptide having threonine aldolase activity.

Engineered Biosynthetic Pathways Using Pyruvate

In embodiments, the recombinant host cells described herein can beengineered to have a biosynthetic pathway for production of a productfrom pyruvate. A product from such a pyruvate-utilizing biosyntheticpathway includes, but is not limited to, 2,3-butanediol, isobutanol,2-butanol, 2-butanone, valine, leucine, alanine, lactic acid, malicacid, fumaric acid, succinic acid and isoamyl alcohol. The features ofany pyruvate-utilizing biosynthetic pathway may be engineered in therecombinant host cells described herein in any order. Any product madeusing a biosynthetic pathway that has pyruvate as the initial substratecan be produced with greater effectiveness in a recombinant host celldisclosed herein having a modification in an endogenous polypeptide thatconverts pyruvate to acetaldehyde, acetyl-phosphate or acetyl-CoA (suchas pyruvate decarboxylase, pyruvate formate lyase, pyruvatedehydrogenase, pyruvate oxidase, or pyruvate:ferredoxin oxioreductase)and having heterologous phosphoketolase and/or phosphotransacetylaseactivity, compared to a recombinant host cell having a modification inan endogenous polypeptide that converts pyruvate to acetaldehyde,acetyl-phosphate or acetyl-CoA (such as pyruvate decarboxylase, pyruvateformate lyase, pyruvate dehydrogenase, pyruvate oxidase, orpyruvate:ferredoxin oxioreductase). Any product made using abiosynthetic pathway that has pyruvate as the initial substrate can beproduced with greater effectiveness in a recombinant host cell disclosedherein having a modification in an endogenous polypeptide having PDCactivity that reduces or eliminates PDC activity and having heterologousphosphoketolase and/or phosphotransacetylase activity, compared to arecombinant host cell having a modification in an endogenous polypeptidehaving PDC activity that reduces or eliminates PDC activity.

The biosynthetic pathway of the recombinant host cells described hereincan be any pathway that utilizes pyruvate and produces a desiredproduct. The pathway genes may include endogenous genes and/orheterologous genes. Typically at least one gene in the biosyntheticpathway is a heterologous gene. Suitable biosynthetic pathways forproduction of butanol are known in the art, and certain suitablepathways are described herein. In some embodiments, the butanolbiosynthetic pathway comprises at least one gene that is heterologous tothe host cell. In some embodiments, the butanol biosynthetic pathwaycomprises more than one gene that is heterologous to the host cell. Insome embodiments, the butanol biosynthetic pathway comprisesheterologous genes encoding polypeptides corresponding to every step ofa biosynthetic pathway.

Genes and polypeptides that can be used for substrate to productconversions described herein as well as methods of identifying suchgenes and polypeptides, are described herein and/or in the art, forexample, for isobutanol, in the Examples and in U.S. Pat. No. 7,851,188.Ketol-acid reductoisomerase (KARI) enzymes are described in U.S. PatentAppl. Pub. Nos. 20080261230 A1, 20090163376 A1, 20100197519 A1, and PCTAppl. Pub. No. WO/2011/041415. Examples of KARIs disclosed therein arethose from Lactococcus lactis, Vibrio cholera, Pseudomonas aeruginosaPAO1, and Pseudomonas fluorescens PF5 mutants. KARIs includeAnaerostipes caccae KARI variants “K9G9” and “K9D3” (SEQ ID NOs: 1911and 1910, respectively). US Appl. Pub. No. 20100081154 A1, and U.S. Pat.No. 7,851,188 describe dihydroxyacid dehydratases (DHADs), including aDHAD from Streptococcus mutans. U.S. Patent Appl. Publ. No. 20090269823A1 describes SadB, an alcohol dehydrogenase (ADH) from Achromobacterxylosoxidans. Alcohol dehydrogenases also include horse liver ADH andBeijerinkia indica ADH (protein SEQ ID NO: 1923).

An example of a biosynthetic pathway for producing 2,3-butanediol can beengineered in the recombinant host cells described herein, as describedin U.S. Patent Application No. 20090305363, which is herein incorporatedby reference. The 2,3-butanediol pathway is a portion of the 2-butanolbiosynthetic pathway that is disclosed in U.S. Patent ApplicationPublication No. US 20070292927 A1, which is herein incorporated byreference. Such pathway steps include, but are not limited to,conversion of pyruvate to acetolactate by acetolactate synthase,conversion of acetolactate to acetoin by acetolactate decarboxylase, andconversion of acetoin to 2,3-butanediol by butanediol dehydrogenase. Theskilled person will appreciate that polypeptides having the activity ofsuch pathway steps can be isolated from a variety of sources can be usedin the recombinant host cells described herein.

In addition, examples of biosynthetic pathways for production of2-butanone or 2-butanol that can be engineered in the recombinant hostcells described herein are disclosed in U.S. Patent ApplicationPublication Nos. US 20070292927 A1 and US 20070259410 A1, which areherein incorporated by reference. The pathway in U.S. Patent ApplicationPublication No. US 20070292927 A1 is the same as described forbutanediol production with the addition of the following steps:

-   -   2,3-butanediol to 2-butanone as catalyzed for example by diol        dehydratase or glycerol dehydratase; and    -   2-butanone to 2-butanol as catalyzed for example by butanol        dehydrogenase.

Described in U.S. Patent Application Publication No. US 20090155870 A1,which is herein incorporated by reference, is the construction ofchimeric genes and genetic engineering of yeast for 2-butanol productionusing the U.S. Patent Application Publication No. US 20070292927 A1disclosed biosynthetic pathway. Further description for geneconstruction and expression related to these pathways can be found, forexample, in International Publication No. WO 2009046370 (e.g.,butanediol dehydratases); and U.S. Patent Application Publication No. US20090269823 A1 (e.g., butanol dehydrogenase) and U.S. Patent ApplicationPublication No. US 20070259410 A1 which are herein incorporated byreference. The skilled person will appreciate that polypeptides havingthe activity of such pathway steps can be isolated from a variety ofsources can be used in the recombinant host cells described herein.

Biosynthetic pathways for the production of isobutanol that may be usedinclude those described in U.S. Pat. No. 7,851,188 and PCT PublicationWO 2007050671, incorporated herein by reference. One isobutanolbiosynthetic pathway comprises the following substrate to productconversions:

-   -   pyruvate to acetolactate, which may be catalyzed, for example,        by acetolactate synthase;    -   acetolactate to 2,3-dihydroxyisovalerate, which may be        catalyzed, for example, by acetohydroxy acid reductoisomerase;    -   2,3-dihydroxyisovalerate to a-ketoisovalerate, which may be        catalyzed, for example, by acetohydroxy acid dehydratase;    -   α-ketoisovalerate to isobutyraldehyde, which may be catalyzed,        for example, by a branched-chain keto acid decarboxylase; and    -   isobutyraldehyde to isobutanol, which may be catalyzed, for        example, by a branched-chain alcohol dehydrogenase. In some        embodiments, the isobutanol biosynthetic pathway comprises at        least one gene, at least two genes, at least three genes, or at        least four genes that is/are heterologous to the yeast cell. In        embodiments, each substrate to product conversion of an        isobutanol biosynthetic pathway in a recombinant host cell is        catalyzed by a heterologous polypeptide. In embodiments, the        polypeptide catalyzing the substrate to product conversions of        acetolactate to 2,3-dihydroxyisovalerate and/or the polypeptide        catalyzing the substrate to product conversion of        isobutyraldehyde to isobutanol are capable of utilizing NADH as        a cofactor.

An example of a biosynthetic pathway for production of valine that canbe engineered in the recombinant host cells described herein includesthe steps of acetolactate conversion to 2,3-dihydroxy-isovalerate byacetohydroxyacid reductoisomerase (ILV5), conversion of2,3-dihydroxy-isovalerate to 2-keto-isovalerate by dihydroxy-aciddehydratase (ILV3), and conversion of 2-keto-isovalerate to valine bybranched-chain amino acid transaminase (BAT2) and branched-chain aminoacid aminotransferase (BAT1). Biosynthesis of leucine includes the samesteps to 2-keto-isovalerate, followed by conversion of2-keto-isovalerate to alpha-isopropylmalate by alpha-isopropylmalatesynthase (LEU9, LEU4), conversion of alpha-isopropylmalate tobeta-isopropylmalate by isopropylmalate isomerase (LEU1), conversion ofbeta-isopropylmalate to alpha-ketoisocaproate by beta-IPM dehydrogenase(LEU2), and finally conversion of alpha-ketoisocaproate to leucine bybranched-chain amino acid transaminase (BAT2) and branched-chain aminoacid aminotransferase (BAT1). It is desired for production of valine orleucine to overexpress at least one of the enzymes in these describedpathways.

An example of a biosynthetic pathway for production of isoamyl alcoholthat can be engineered in the recombinant host cells described hereinincludes the steps of leucine conversion to alpha-ketoisocaproate bybranched-chain amino acid transaminase (BAT2) and branched-chain aminoacid aminotransferase (BAT1), conversion of alpha-ketoisocaproate to3-methylbutanal by ketoisocaproate decarboxylase (THI3) or decarboxylaseARO10, and finally conversion of 3-methylbutanal to isoamyl alcohol byan alcohol dehydrogenase such as ADH1 or SFA1. Production of isoamylalcohol benefits from increased production of leucine or thealpha-ketoisocaproate intermediate by overexpression of one or moreenzymes in biosynthetic pathways for these chemicals. In addition, oneor both enzymes for the final two steps can be overexpressed.

An example of a biosynthetic pathway for production of lactic acid thatcan be engineered in the recombinant host cells described hereinincludes pyruvate conversion to lactic acid by lactate dehydrogenase.Engineering yeast for lactic acid production using lactatedehydrogenase, known as EC 1.1.1.27, is well known in the art such as inIshida et al. (Appl. Environ. Microbiol. 71:1964-70 (2005)).

An example of a biosynthetic pathway for production of alanine that canbe engineered in the recombinant host cells described herein includespyruvate conversion to alanine by aminotransferase.

An example of a biosynthetic pathway for production of malate that canbe engineered in the recombinant host cells described herein includespyruvate conversion to oxaloacetate by pyruvate carboxylase, andconversion of oxaloacetate to malate by malate dehydrogenase asdescribed in Zelle et al. (Applied and Environmental Microbiology74:2766-77 (2008)). In addition, a malate transporter can be expressed.

An example of a biosynthetic pathway for production of fumarate that canbe engineered in the recombinant host cells described herein includespyruvate conversion to oxaloacetate by pyruvate carboxylase, andconversion of oxaloacetate to malate by malate dehydrogenase asdescribed in Zelle et al. (Applied and Environmental Microbiology74:2766-77 (2008)). In addition, a fumarase and a fumarate transportercan be expressed. Favorable production conditions and engineering offungi for fumarate production is well known in the art, described e.g.by Goldberg et al. (Journal of Chemical Technology and Biotechnology81:1601-1611 (2006)).

An example of a biosynthetic pathway for production of succinate thatcan be engineered in the recombinant host cells described hereinincludes pyruvate conversion to oxaloacetate by pyruvate carboxylase,and conversion of oxaloacetate to malate by malate dehydrogenase asdescribed in Zelle et al. (Applied and Environmental Microbiology74:2766-77 (2008)). In addition, a fumarase, a succinate dehydrogenaseand a succinate transporter can be expressed.

The skilled person will appreciate that polypeptides having activitiesof the above-mentioned biosynthetic pathways can be isolated from avariety of sources can be used in the recombinant host cells describedherein.

It will be appreciated that host cells comprising a butanol biosyntheticpathway such as an isobutanol biosynthetic pathway as provided hereinmay further comprise one or more additional modifications. U.S. Appl.Pub. No. 20090305363 (incorporated by reference) discloses increasedconversion of pyruvate to acetolactate by engineering yeast forexpression of a cytosol-localized acetolactate synthase and substantialelimination of pyruvate decarboxylase activity. Modifications to reduceglycerol-3-phosphate dehydrogenase activity and/or disruption in atleast one gene encoding a polypeptide having pyruvate decarboxylaseactivity or a disruption in at least one gene encoding a regulatoryelement controlling pyruvate decarboxylase gene expression as describedin U.S. Patent Appl. Pub. No. 20090305363 (incorporated herein byreference), modifications to a host cell that provide for increasedcarbon flux through an Entner-Doudoroff Pathway or reducing equivalentsbalance as described in U.S. Patent Appl. Pub. No. 20100120105(incorporated herein by reference). Other modifications includeintegration of at least one polynucleotide encoding a polypeptide thatcatalyzes a step in a pyruvate-utilizing biosynthetic pathway. Othermodifications include at least one deletion, mutation, and/orsubstitution in an endogenous polynucleotide encoding a polypeptidehaving acetolactate reductase activity. In embodiments, the polypeptidehaving acetolactate reductase activity is YMR226c (SEQ ID NO: 1912) ofSaccharomyces cerevisae or a homolog thereof. Additional modificationsinclude a deletion, mutation, and/or substitution in an endogenouspolynucleotide encoding a polypeptide having aldehyde dehydrogenaseand/or aldehyde oxidase activity. In embodiments, the polypeptide havingaldehyde dehydrogenase activity is ALD6 (SEQ ID NO: 1909) fromSaccharomyces cerevisiae or a homolog thereof. A genetic modificationwhich has the effect of reducing glucose repression wherein the yeastproduction host cell is pdc− is described in U.S. Appl. Publication No.20110124060, incorporated herein by reference.

Recombinant host cells may further comprise (a) at least oneheterologous polynucleotide encoding a polypeptide having dihydroxy-aciddehydratase activity; and (b)(i) at least one deletion, mutation, and/orsubstitution in an endogenous gene encoding a polypeptide affecting Fe—Scluster biosynthesis; and/or (ii) at least one heterologouspolynucleotide encoding a polypeptide affecting Fe—S clusterbiosynthesis. In embodiments, the polypeptide affecting Fe—S clusterbiosynthesis is encoded by AFT1 (nucleic acid SEQ ID NO: 1913, aminoacid SEQ ID NO: 1914), AFT2 (SEQ ID NOs: 1915 and 1916), FRA2 (SEQ IDNOs: 1917 and 1918), GRX3 (SEQ ID NOs: 1919 and 1920), or CCC1 (SEQ IDNOs: 1921 and 1922). In embodiments, the polypeptide affecting Fe—Scluster biosynthesis is constitutive mutant AFT1 L99A, AFT1 L102A, AFT1C291F, or AFT1 C293F.

Fermentation Media

The recombinant host cells disclosed herein can be grown in fermentationmedia for production of a product utilizing pyruvate. For maximalproduction of some products, such as 2,3-butanediol, isobutanol,2-butanone, or 2-butanol, the recombinant host cells disclosed hereinused as production hosts preferably have enhanced tolerance to theproduced chemical, and have a high rate of carbohydrate utilization.These characteristics can be conferred by mutagenesis and selection,genetic engineering, or can be natural.

Fermentation media for production of the products disclosed herein maycontain glucose. Additional carbon substrates for product productionpathways can include but are not limited to those described above. It iscontemplated that the source of carbon utilized can encompass a widevariety of carbon containing substrates and will only be limited by thechoice of organism.

In addition to an appropriate carbon source, fermentation media cancontain suitable minerals, salts, cofactors, buffers and othercomponents, known to those skilled in the art, suitable for the growthof the cultures and promotion of the enzymatic pathway necessary forproduction of the desired product.

Culture Conditions

Typically cells are grown at a temperature in the range of about 20° C.to about 37° C. in an appropriate medium. Suitable growth media for therecombinant host cells described herein are common commercially preparedmedia such as broth that includes yeast nitrogen base, ammonium sulfate,and dextrose as the carbon/energy source) or YPD Medium, a blend ofpeptone, yeast extract, and dextrose in optimal proportions for growingmost Saccharomyces cerevisiae strains. Other defined or synthetic growthmedia may also be used and the appropriate medium for growth of theparticular microorganism will be known by one skilled in the art ofmicrobiology or fermentation science.

Suitable pH ranges for the fermentation are between pH 3.0 to pH 7.5,where pH 4.5 to pH 6.5 is preferred as the initial condition.

Fermentations can be performed under aerobic or anaerobic conditions,where anaerobic or microaerobic conditions are preferred.

The amount of product in the fermentation medium can be determined usinga number of methods known in the art, for example, high performanceliquid chromatography (HPLC) or gas chromatography (GC).

Industrial Batch and Continuous Fermentations

A batch method of fermentation can be used with the recombinant hostcells described herein. A classical batch fermentation is a closedsystem where the composition of the medium is set at the beginning ofthe fermentation and not subject to artificial alterations during thefermentation. Thus, at the beginning of the fermentation the medium isinoculated with the desired organism or organisms, and fermentation ispermitted to occur without adding anything to the system. Typically,however, a “batch” fermentation is batch with respect to the addition ofcarbon source and attempts are often made at controlling factors such aspH and oxygen concentration. In batch systems the metabolite and biomasscompositions of the system change constantly up to the time thefermentation is stopped. Within batch cultures cells progress through astatic lag phase to a high growth log phase and finally to a stationaryphase where growth rate is diminished or halted. If untreated, cells inthe stationary phase will eventually die. Cells in log phase generallyare responsible for the bulk of production of end product orintermediate.

A Fed-Batch system can also be used with the recombinant host cellsdescribed herein. A Fed-Batch system is similar to a typical batchsystem with the exception that the carbon source substrate is added inincrements as the fermentation progresses. Fed-Batch systems are usefulwhen catabolite repression (e.g. glucose repression) is apt to inhibitthe metabolism of the cells and where it is desirable to have limitedamounts of substrate in the media. Measurement of the actual substrateconcentration in Fed-Batch systems is difficult and is thereforeestimated on the basis of the changes of measurable factors such as pH,dissolved oxygen and the partial pressure of waste gases such as CO₂.Batch and Fed-Batch fermentations are common and well known in the artand examples may be found in Thomas D. Brock in Biotechnology: ATextbook of Industrial Microbiology, Second Edition (1989) SinauerAssociates, Inc., Sunderland, Mass., or Deshpande, Mukund V., Appl.Biochem. Biotechnol., 36:227, (1992), herein incorporated by reference.

Although a batch mode can be performed, it is also contemplated thatcontinuous fermentation methods could also be performed with therecombinant host cells described herein. Continuous fermentation is anopen system where a defined fermentation medium is added continuously toa bioreactor and an equal amount of conditioned media is removedsimultaneously for processing. Continuous fermentation generallymaintains the cultures at a constant high density where cells areprimarily in log phase growth.

Continuous fermentation allows for the modulation of one factor or anynumber of factors that affect cell growth or end product concentration.For example, one method will maintain a limiting nutrient such as thecarbon source or nitrogen level at a fixed rate and allow all otherparameters to vary. In other systems a number of factors affectinggrowth can be altered continuously while the cell concentration,measured by media turbidity, is kept constant. Continuous systems striveto maintain steady state growth conditions and thus the cell loss due tothe medium being drawn off must be balanced against the cell growth ratein the fermentation. Methods of modulating nutrients and growth factorsfor continuous fermentation processes as well as techniques formaximizing the rate of product formation are well known in the art ofindustrial microbiology and a variety of methods are detailed by Brock,supra.

It is contemplated that the present invention can be practiced usingeither batch, fed-batch or continuous processes and that any known modeof fermentation would be suitable. Additionally, it is contemplated thatcells can be immobilized on a substrate as whole cell catalysts andsubjected to fermentation conditions for production.

Product Isolation from Fermentation Medium

Products can be isolated from the fermentation medium by methods knownto one skilled in the art. For example, bioproduced isobutanol may beisolated from the fermentation medium using methods known in the art forABE fermentations (see, e.g., Durre, Appl. Microbiol. Biotechnol.49:639-648 (1998), Groot et al., Process. Biochem. 27:61-75 (1992), andreferences therein). For example, solids may be removed from thefermentation medium by centrifugation, filtration, decantation, or thelike. Then, the isobutanol may be isolated from the fermentation mediumusing methods such as distillation, azeotropic distillation,liquid-liquid extraction, adsorption, gas stripping, membraneevaporation, pervaporation or vacuum flash fermentation (see e.g., U.S.Pub. No. 20090171129 A1, and International Pub. No. WO2010/151832 A1,both incorporated herein by reference in their entirety).

Because butanol forms a low boiling point, azeotropic mixture withwater, distillation can be used to separate the mixture up to itsazeotropic composition. Distillation may be used in combination withanother separation method to obtain separation around the azeotrope.Methods that may be used in combination with distillation to isolate andpurify butanol include, but are not limited to, decantation,liquid-liquid extraction, adsorption, and membrane-based techniques.Additionally, butanol may be isolated using azeotropic distillationusing an entrainer (see, e.g., Doherty and Malone, Conceptual Design ofDistillation Systems, McGraw Hill, New York, 2001).

The butanol-water mixture forms a heterogeneous azeotrope so thatdistillation may be used in combination with decantation to isolate andpurify the isobutanol. In this method, the isobutanol containingfermentation broth is distilled to near the azeotropic composition.Then, the azeotropic mixture is condensed, and the isobutanol isseparated from the fermentation medium by decantation. The decantedaqueous phase may be returned to the first distillation column asreflux. The isobutanol-rich decanted organic phase may be furtherpurified by distillation in a second distillation column.

The butanol can also be isolated from the fermentation medium usingliquid-liquid extraction in combination with distillation. In thismethod, the isobutanol is extracted from the fermentation broth usingliquid-liquid extraction with a suitable solvent. Theisobutanol-containing organic phase is then distilled to separate thebutanol from the solvent.

Distillation in combination with adsorption can also be used to isolateisobutanol from the fermentation medium. In this method, thefermentation broth containing the isobutanol is distilled to near theazeotropic composition and then the remaining water is removed by use ofan adsorbent, such as molecular sieves (Aden et al., LignocellulosicBiomass to Ethanol Process Design and Economics Utilizing Co-CurrentDilute Acid Prehydrolysis and Enzymatic Hydrolysis for Corn Stover,Report NREL/TP-510-32438, National Renewable Energy Laboratory, June2002).

Additionally, distillation in combination with pervaporation may be usedto isolate and purify the isobutanol from the fermentation medium. Inthis method, the fermentation broth containing the isobutanol isdistilled to near the azeotropic composition, and then the remainingwater is removed by pervaporation through a hydrophilic membrane (Guo etal., J. Membr. Sci. 245, 199-210 (2004)).

In situ product removal (ISPR) (also referred to as extractivefermentation) can be used to remove butanol (or other fermentativealcohol) from the fermentation vessel as it is produced, therebyallowing the microorganism to produce butanol at high yields. One methodfor ISPR for removing fermentative alcohol that has been described inthe art is liquid-liquid extraction. In general, with regard to butanolfermentation, for example, the fermentation medium, which includes themicroorganism, is contacted with an organic extractant at a time beforethe butanol concentration reaches a toxic level. The organic extractantand the fermentation medium form a biphasic mixture. The butanolpartitions into the organic extractant phase, decreasing theconcentration in the aqueous phase containing the microorganism, therebylimiting the exposure of the microorganism to the inhibitory butanol.

Liquid-liquid extraction can be performed, for example, according to theprocesses described in U.S. Patent Appl. Pub. No. 20090305370, thedisclosure of which is hereby incorporated in its entirety. U.S. PatentAppl. Pub. No. 20090305370 describes methods for producing andrecovering butanol from a fermentation broth using liquid-liquidextraction, the methods comprising the step of contacting thefermentation broth with a water immiscible extractant to form atwo-phase mixture comprising an aqueous phase and an organic phase.Typically, the extractant can be an organic extractant selected from thegroup consisting of saturated, mono-unsaturated, poly-unsaturated (andmixtures thereof) C₁₂ to C₂₂ fatty alcohols, C₁₂ to C₂₂ fatty acids,esters of C₁₂ to C₂₂ fatty acids, C₁₂ to C₂₂ fatty aldehydes, andmixtures thereof. The extractant(s) for ISPR can be non-alcoholextractants. The ISPR extractant can be an exogenous organic extractantsuch as oleyl alcohol, behenyl alcohol, cetyl alcohol, lauryl alcohol,myristyl alcohol, stearyl alcohol, 1-undecanol, oleic acid, lauric acid,myristic acid, stearic acid, methyl myristate, methyl oleate, undecanal,lauric aldehyde, 20-methylundecanal, and mixtures thereof.

In some embodiments, the alcohol can be esterfied by contacting thealcohol in a fermentation medium with an organic acid (e.g., fattyacids) and a catalyst (e.g. enzyme such as a lipase) capable ofesterfiying the alcohol with the organic acid. In such embodiments, theorganic acid can serve as an ISPR extractant into which the alcoholesters partition. The organic acid can be supplied to the fermentationvessel and/or derived from the biomass supplying fermentable carbon fedto the fermentation vessel. Lipids present in the feedstock can becatalytically hydrolyzed to organic acid, and the same catalyst (e.g.,enzymes) can esterify the organic acid with the alcohol. The catalystcan be supplied to the feedstock prior to fermentation, or can besupplied to the fermentation vessel before or contemporaneously with thesupplying of the feedstock. When the catalyst is supplied to thefermentation vessel, alcohol esters can be obtained by hydrolysis of thelipids into organic acid and substantially simultaneous esterificationof the organic acid with butanol present in the fermentation vessel.Organic acid and/or native oil not derived from the feedstock can alsobe fed to the fermentation vessel, with the native oil being hydrolyzedinto organic acid. Any organic acid not esterified with the alcohol canserve as part of the ISPR extractant. The extractant containing alcoholesters can be separated from the fermentation medium, and the alcoholcan be recovered from the extractant. The extractant can be recycled tothe fermentation vessel. Thus, in the case of butanol production, forexample, the conversion of the butanol to an ester reduces the freebutanol concentration in the fermentation medium, shielding themicroorganism from the toxic effect of increasing butanol concentration.In addition, unfractionated grain can be used as feedstock withoutseparation of lipids therein, since the lipids can be catalyticallyhydrolyzed to organic acid, thereby decreasing the rate of build-up oflipids in the ISPR extractant.

In situ product removal can be carried out in a batch mode or acontinuous mode. In a continuous mode of in situ product removal,product is continually removed from the reactor. In a batchwise mode ofin situ product removal, a volume of organic extractant is added to thefermentation vessel and the extractant is not removed during theprocess. For in situ product removal, the organic extractant can contactthe fermentation medium at the start of the fermentation forming abiphasic fermentation medium. Alternatively, the organic extractant cancontact the fermentation medium after the microorganism has achieved adesired amount of growth, which can be determined by measuring theoptical density of the culture. Further, the organic extractant cancontact the fermentation medium at a time at which the product alcohollevel in the fermentation medium reaches a preselected level. In thecase of butanol production according to some embodiments of the presentinvention, the organic acid extractant can contact the fermentationmedium at a time before the butanol concentration reaches a toxic level,so as to esterify the butanol with the organic acid to produce butanolesters and consequently reduce the concentration of butanol in thefermentation vessel. The ester-containing organic phase can then beremoved from the fermentation vessel (and separated from thefermentation broth which constitutes the aqueous phase) after a desiredeffective titer of the butanol esters is achieved. In some embodiments,the ester-containing organic phase is separated from the aqueous phaseafter fermentation of the available fermentable sugar in thefermentation vessel is substantially complete.

EXAMPLES

The meaning of abbreviations used is as follows: “min” means minute(s),“h” means hour(s), “sec” means second(s), “μl” means microliter(s), “ml”means milliliter(s), “L” means liter(s), “nm” means nanometer(s), “mm”means millimeter(s), “cm” means centimeter(s), “μm” means micrometer(s),“mM” means millimolar, “M” means molar, “mmol” means millimole(s),“μmole” means micromole(s), “g” means gram(s), “μg” means microgram(s),“mg” means milligram(s), “rpm” means revolutions per minute, “w/v” meansweight/volume, “v/v” means volume/volume, “OD” means optical density,“bp” means base pair(s), and “PCR” means polymerase chain reaction.

General Methods:

Standard recombinant DNA and molecular cloning techniques used in theExamples are well known in the art and are described by Sambrook, J.,Fritsch, E. F. and Maniatis, T., Molecular Cloning: A Laboratory Manual,Cold Spring Harbor Laboratory Press, Cold Spring Harbor, N.Y., 1989, byT. J. Silhavy, M. L. Bennan, and L. W. Enquist, Experiments with GeneFusions, Cold Spring Harbor Laboratory, Cold Spring Harbor, N.Y., 1984,and by Ausubel, F. M. et al., Current Protocols in Molecular Biology,Greene Publishing Assoc. and Wiley-Interscience, N.Y., 1987. Phusion® HFMaster Mix (NEB Cat. No. F-531) and HotStarTaq® Master Mix (Qiagen Cat.No. 203443) were used for PCR in gene cloning and clone screening,respectively.

Materials and methods suitable for the maintenance and growth ofbacterial cultures are also well known in the art. Techniques suitablefor use in the following Examples may be found in Manual of Methods forGeneral Bacteriology, Phillipp Gerhardt, R. G. E. Murray, Ralph N.Costilow, Eugene W. Nester, Willis A. Wood, Noel R. Krieg and G. BriggsPhillips, eds., American Society for Microbiology, Washington, D.C.,1994, or by Thomas D. Brock in Biotechnology: A Textbook of IndustrialMicrobiology, Second Edition, Sinauer Associates, Inc., Sunderland,Mass., 1989. All reagents, restriction enzymes and materials used forthe growth and maintenance of bacterial cells were obtained from AldrichChemicals (Milwaukee, Wis.), BD Diagnostic Systems (Sparks, Md.), LifeTechnologies (Rockville, Md.), or Sigma Chemical Company (St. Louis,Mo.), unless otherwise specified.

HPLC

Analysis for fermentation by-product composition is well known to thoseskilled in the art. For example, one high performance liquidchromatography (HPLC) method utilizes a Shodex SH-1011 column with aShodex SH-G guard column (both available from Waters Corporation,Milford, Mass.), with refractive index (RI) detection. Chromatographicseparation is achieved using 0.01 M H₂SO₄ as the mobile phase with aflow rate of 0.5 mL/min and a column temperature of 50° C. Isobutanolretention time is 47.6 minutes. For butanediol, meso-butanediol elutedat 26.0 min and 2R,3R-butanediol eluted at 27.7 min.

Example 1 Construction of Phosphoketolase/PhosphotransacetylaseExpression Cassette

The xpk1 and eutD genes (GenBank GI numbers 28379168 (SEQ ID NO: 172)and 28377658 (SEQ ID NO: 1111), respectively) were obtained fromLactobacillus plantarum (ATCC No. BAA-793) via polymerase chain reaction(PCR) using primers N1039 and N1040 (for xpk1) and N1041 and N1042 (foreutD). The primer sequences of N1039, N1040, N1041 and N1042 correspondto SEQ ID Nos. 639-642, respectively.

The xpk1 and eutD genes were fused to a DNA fragment containing opposingyeast terminator sequences (CYC and ADH terminators, obtained from Paddigestion of pRS423::CUP1-alsS+FBA-budA, described in U.S. PatentApplication Publication No. 20090155870, herein incorporated byreference) by overlap PCR method (Yu et al., Fungal Genet. Biol. 41:973-981; 2003). The resulting PCR product was cloned into an E.coli-yeast shuttle vector using gap repair methodology (Ma et al.,Genetics 58:201-216; 1981). The shuttle vector was based on pRS426 (ATCCNo. 77107) and contained both GPD (also known as TDH3) and ADH1promoters. The resulting vector contained xpk1 under control of the GPDpromoter and eutD under control of the ADH1 promoter in opposingorientation. The sequence of the resulting vector(pRS426::GPD-xpk1+ADH1-eutD) is provided as SEQ ID No: 643 (see FIG. 5for a map of this vector).

Example 2 Construction of Phosphoketolase/PhosphotransacetylaseIntegration Vector

An expression cassette of the pRS426::GPD-xpk1+ADH1-eutD vector(GPD-xpk1+ADH1-eutD) was prepared by digestion with EcoRI and Sadrestriction enzymes. The resulting cassette was ligated into the yeastintegration vector pUC19-URA3-MCS which was also prepared by digestionwith EcoRI and Sad restriction enzymes.

Vector pUC19-URA3MCS is pUC19-based and contains the sequence of theURA3 gene from Saccaromyces cerevisiae situated within a multiplecloning site (MCS). pUC19 (American Type Culture Collection, Manassas,Va.; ATCC#37254) contains the pMB 1 replicon and a gene coding forbeta-lactamase for replication and selection in Escherichia coli. Inaddition to the coding sequence for URA3, the sequences from upstreamand downstream of this gene are included for expression of the URA3 genein yeast. The vector can be used for cloning purposes and can be used asa yeast integration vector.

The DNA encompassing the URA3 coding region along with 250 bp upstreamand 150 bp downstream of the URA3 coding region from Saccaromycescerevisiae CEN.PK 113-7D (CBS 8340; Centraalbureau voor Schimmelcultures(CBS) Fungal Biodiversity Centre, Netherlands) genomic DNA was amplifiedwith primers oBP438 (SEQ ID NO: 644), containing BamHI, AscI, PmeI, andFseI restriction sites, and oBP439 (SEQ ID NO: 645), containing XbaI,PacI, and NotI restriction sites. Genomic DNA was prepared using aGentra Puregene Yeast/Bact kit (Qiagen). The PCR product and pUC19 wereligated with T4 DNA ligase after digestion with BamHI and XbaI to createvector pUC19-URA3MCS. The vector was confirmed by PCR and sequencingwith primers oBP264 (SEQ ID NO:646) and oBP265 (SEQ ID NO:647).

The ligation reaction was transformed into E. coli Stbl3 cells,according to the manufacturer's instructions (Invitrogen, Carlsbad,Calif., Cat. No. C7373). Transformants were screened by polymerase chainreaction (PCR) to detect the eutD gene using the primers N1041 and N1042(SEQ ID NOs: 641 and 642, respectively). Positive clones for eutD geneexpression detected by PCR were further confirmed for eutD geneincorporation by digestion of the vector with SacII restriction enzyme.

Two confirmed clones were selected and an integration targeting sequencewas added to the clones as follows. PCR was used to amplify regions ofthe genome of S. cerevisiae strain BY4700 (ATCC No. 200866) both 5′ and3′ of the PDC1 gene using the following primers: N1049 and N1050 (5′)and N1047 and N1048 (3′) (SEQ ID NOs: 648-651, respectively). PrimerN1049 enables the 3′ end of the 161-bp PDC1 3′ sequence to be fused tothe 5′ end of the 237 bp PDC1 5′ sequence via PCR. This pdc13′-5′-fusion fragment (368 bp in length) was cloned into the pCRII-BluntTOPO vector according to the manufacturer's instructions (Invitrogen,Carlsbad, Calif., Cat. No. K2800).

Transformants were screened by PCR to detect the pdc1 3′-5′-fusionfragment using primers N1047 and N1050. The pdc1 3′-5′-fusion fragmentwas isolated from positive clones and released from the vector bydigestion with EcoRI enzyme, and ligated into apUC19-URA3::GPD-xpk1+ADH-eutD vector that had been linearized bydigestion with EcoRI restriction enzyme to generate the “phosphoketolasepathway” vector. Additionally, the pdc1 3′-5′-fusion fragment wasligated with pUC19-URA3-MCS digested with EcoRI restriction enzyme togenerate the control vector. Both ligation reactions were transformedinto E. coli Stbl3 cells according to the manufacturer's instructions(Invitrogen, Carlsbad, Calif., Cat. No. C7373). The resultingtransformants were screened by PCR to detect the pdc1 3′-5′-fusionfragment using primers N1047 and N1050. Positive clones containing thepdc1 3′-5′-fusion fragment were identified and the vectors were digestedwith either NcoI restriction enzyme (control vector) or BsgI restrictionenzyme (phosphoketolase pathway vector) to confirm cloning orientation.One control clone (=pUC19-URA3::pdc1) and one phosphoketolase pathwayclone (=pUC19-URA3::pdc1::GPD-xpk1+ADH1-eutD; SEQ ID NO: 1898) wereselected for integration.

Example 3 Construction of Pyruvate Decarboxylase Knockout (PDC-KO) YeastStrain Containing Phosphoketolase and Phosphotransacetylase Genes

The control and phosphoketolase pathway vectors described in Example 2were linearized with AIM restriction enzyme and transformed into strainBP913 (CEN.PK113-7D Δura3::loxP Δhis3 Δpdc6 Δpdc1::ilvD(Sm) Δpdc5::sadB)to form control and phosphoketolase pathway strains. Strain BP913 isfurther described in Example 10.

Transformed cells were plated on synthetic complete medium withouturacil containing ethanol as the sole carbon source (1% vol/vol) andscreened by PCR using primers N238 and oBP264 (SEQ ID Nos. 652 and 646,respectively to confirm integration at the pdc1 locus. Integration atthe Δpdc1::ilvD(Sm) locus resulted in the loss of ilvD(Sm).

Example 4 Introduction of Phosphoketolase and PhosphotransacetylaseAllows Growth of PDC-KO Cells Without Exogenous Two-Carbon SubstrateSupplementation

Pyruvate decarboxylase knockout (PDC-KO) yeast strains are unable togrow in media containing 2% glucose as the sole carbon source, but cangrow in 2% glucose supplemented with ethanol as shown with a straintransformed with one or more plasmids encoding members of the butanediolpathway (described in U.S. Patent Application Publication No.20090305363, herein incorporated by reference). To test whether theintroduction of the phosphoketolase and phosphotransacetylase genescould support growth of PDC-KO cells, PDC-KO yeast were transformed withthe phosphoketolase and phosphotransacetylase gene (as described inExample 3) and with the vector pRS423::CUP1-alsS+FBA-budA (described inU.S. Patent Application Publication No. 20090155870, herein incorporatedby reference) encoding members of the butanediol pathway. Aftercultivation in media containing 2% glucose (synthetic complete minus hisand ura) supplemented with 0.05% v/v ethanol, cultures were diluted intothe same media lacking ethanol (starting OD=0.1, 20 ml medium in a 125ml vented flask). For comparison, a control PDC-KO strain withoutintroduction of the phosphoketolase and phosphotransacetylase genes wasalso diluted into medium supplemented with ethanol (0.05% vol/vol). Theoptical density at 600 nm was measured during growth (results shown inFIG. 2 and Table 13).

TABLE 13 Condition Strain 0 h OD 16 h OD 22 h OD 41.3 h OD xpk A 0.12.07 5.63 9.64 xpk B 0.1 2.44 5.93 9.78 xpk C 0.1 2.26 5.83 9.96 controlA 0.1 0.47 0.5 0.822 control B 0.1 0.45 0.51 0.849 control C 0.1 0.50.52 0.879 cont A w/EtOH 0.1 2.01 5.49 11.44 cont B w/EtOH 0.1 2.16 5.711.5 cont C w/EtOH 0.1 2.12 5.76 11.76

The growth of PDC-KO yeast transformed with phosphoketolase andphosphotransacetylase in media that was not supplemented with ethanol(xpkA-xpkC, representing n=3 results) was indistinguishable from thegrowth of PDC-KO yeast strains grown in media containing 2% glucose thatwas supplemented with ethanol (cont A-cont C w/EtOH, representing n=3results). The average growth rate of the phosphoketolase- andphosphotransacetylase-transformed strains under these conditions was0.19 h⁻¹. A growth rate of 0.23 h⁻¹ for the phosphoketolase- andphosphotransacetylase-transformed strains was observed upon culturingunder the same conditions with higher aeration (data not shown). PDC-KOyeast strains grown in media containing 2% glucose that was notsupplemented with ethanol showed some growth in the first 16 hours, butthen grew at a rate of only 0.01 h⁻¹ (control A-control C, representingn=3 results).

Example 5 Construction of Pyruvate Decarboxylase Knockout (PDC-KO) YeastStrains Containing Either Phosphoketolase or Phosphotransacetylase Genes

The integration vector described above(pUC19-URA3::pdc1::GPD-xpk1+ADH1-eutD) was modified to eliminate eitherthe xpk1 phosphoketolase gene or the eutD phosphotransacetylase gene.Specifically, to remove eutD, the integration vector was digested withthe ClaI and SpeI restriction enzymes to remove a 0.6 kb region from theeutD coding sequence, forming the vector pUC19-URA3::pdc1::GPD-xpk1. Toremove xpk1, the integration vector was digested with the SpeI and KpnIrestriction enzymes to remove the 3.4 kb region from SpeI to KpnI,forming the vector pUC19-URA3::pdc1::ADH-eutD. The resulting vectors,were linearized with digestion with the AflII restriction enzyme andtransformed into BP913/pRS423::CUP1-alsS+FBA-budA cells (described inExample 3). Transformed cells were screened by PCR to confirmintegration at the pdc1 locus and cultured, as described above.

Example 6 Introduction of Phosphoketolase Allows Growth of PDC-KO CellsWithout Exogenous Two-Carbon Substrate Supplementation

To test whether the introduction of either the phosphoketolase orphosphotransacetylase genes could support the growth of PDC-KO cells,PDC-KO yeast were transformed with either the phosphoketolase orphosphotransacetylase genes (as described in Example 5) and with thevector pRS423::CUP1-alsS+FBA-budA encoding members of the butanediolpathway (as described in Example 4). After cultivation in mediacontaining 2% glucose (synthetic complete minus his and ura)supplemented with 0.05% v/v ethanol, cultures were diluted into the samemedia lacking ethanol (starting OD=0.1, 20 ml medium in a 125 ml ventedflask). For comparison, a PDC-KO strain without introduction of thephosphoketolase or phosphotransacetylase genes were grown under the sameconditions. The optical density at 600 nm was measured during growth(results shown in FIG. 3 and Table 15).

TABLE 15 Strain 0 h OD 24 h OD xpk1 + eutD 0.1 7.48 none (control) 0.10.575 eutD only 0.1 0.338 eutD only 0.1 0.28 xpk1 only 0.1 6.74 xpk1only 0.1 7.26

The growth of PDC-KO yeast transformed with phosphoketolase in mediathat was not supplemented with exogenous carbon substrate (xpk1, FIG. 3)was indistinguishable from the growth of PDC-KO yeast transformed withphosphoketolase and phosphotransacetylase grown in media containing 2%glucose that was supplemented with ethanol (xpk1+eutD, FIG. 3). Thegrowth of PDC-KO yeast transformed with phosphotransacetylase (eutD,FIG. 3) was not significantly improved compared to PDC-KO yeast strainsin media that was not supplemented with exogenous two-carbon substrate(none, FIG. 3).

Example 7 Introduction of Phosphoketolase to PDC-KO Cells IncreasesGlucose Consumption and Butanediol Yield

To test the effects of introduction of phosphoketolase into PDC-KO cellson glucose consumption and butanediol yield, PDC-KO yeast weretransformed with either (1) phosphoketolase and phosphotransacetylase(as described in Example 4) and the vector pRS423::CUP1-alsS+FBA-budAencoding members of the butanediol (BDO) pathway (as described inExample 4) (“Xpk” in Table 16 below); or with (2) the vectorpRS423::CUP1-alsS+FBA-budA encoding members of the butanediol pathway(“Control” in Table 6 below).

After cultivation in medium containing 2% glucose (synthetic completeminus histidine and uracil) supplemented with 0.05% ethanol, Xpk andControl cultures were diluted into medium without ethanol (startingOD=0.1, 20 ml medium in a 125 ml vented flask). Glucose consumption andbutanediol yield of Xpk and Control cultures were measured by HPLCanalysis of culture media for amount of glucose and butanediol as shownin the Table below.

TABLE 16 Introduction of Phosphoketolase Increases Glucose Consumptionand Butanediol Yield of PDC-KO Cells. Glucose Butanediol consumed MolarStrains (mM) Yield Xpk (n = 3) 73.9 ± 2.4 0.475 ± 0.001 Control 48.3 ±0.6 0.359 ± 0.003 (n = 3)

The glucose consumption of Xpk cells (n=3) was nearly twice the amountof glucose consumption of control strains (n=3). In addition, thebutanediol molar yield of Xpk cells was increased compared to thebutanediol molar yield of Control cells.

Example 8 Construction of an Additional Phosphoketolase PathwayIntegration Vector

A phosphoketolase/phosphotransacetylase integration vector similar tothe one described in Example 2 was constructed. In this case the xpk1and eutD gene constructs were cloned so that they would be integratedimmediately downstream of the Δpdc1::ilvD(Sm) locus of BP913. To dothis, the intergenic region between ilvD(Sm) and TRX1 was amplified fromBP913 genomic DNA using primers N1110 and N1111 (SEQ ID Nos. 653 and654). This was cloned into pUC19-URA3-MCS at the PmeI site, as follows.The ilvD-TRX1 PCR product was phosphorylated with polynucleotide kinase(NEB Cat. No. M0201), the vector was prepared by digesting with PmeI andtreating with calf intestinal phosphatase, the two fragments wereligated overnight and cloned into E. coli Stbl3 cells. Clones werescreened by PCR (using N1110 and N1111 primers) and then digested withBsgI to determine the orientation of the ilvD-TRX1 insertion. One clonefrom each orientation (pUC19-URA3::ilvD-TRX1 A and B) was carried overto the next step: addition of the xpk1/eutD expression cassette. Thexpk1/eutD expression cassette from pRS426::GPD-xpk1+ADH1-eutD wasobtained by digestion with B gill and EcoRV. The 5′ overhanging DNA wasfilled in using Klenow Fragment. pUC19-URA3::ilvD-TRX1 was linearizedwith AflII and the 5′ overhanging DNA was filled in using Klenowfragment. This vector was then ligated with the prepared xpk1/eutDcassette. Ligation reactions were transformed into E. coli Stbl3 cells.Clones were screened using primers for eutD (N1041 and N1042) and thendigested with BamHI to determine orientation of the xpk1/eutD cassetterelative to the ilvD-TRX1 DNA sequence.

The URA3 marker gene was then replaced with a geneticin resistancemarker as follows. A chimeric geneticin resistance gene was constructedthat contained the Kluyveromyces lactis TEF1 promoter and terminator(TEF1p-kan-TEF1t gene, provided as SEQ ID No. 655). This gene wasmaintained in a pUC19 vector (cloned at the SmaI site). The kan gene wasisolated from pUC19 by first digesting with KpnI, removal of 3′overhanging DNA using Klenow Fragment (NEB, Cat. No. M212), digestingwith HincII and then gel purifying the 1.8 kb gene fragment (Zymoclean™Gel DNA Recovery Kit, Cat. No. D4001, Zymo Research, Orange, Calif.).The URA3 marker was removed frompUC19-URA3::ilvD::GPD-xpk1+ADH1-eutD::TRX1 (paragraph above) using NsiIand NaeI (the 3′ overhanging DNA from NsiI digestion was removed withKlenow fragment). The vector and kan gene were ligated overnight andtransformed into E. coli Stbl3 cells. Clones were screened by PCR usingprimers BK468 and either N1090 or N1113 (SEQ ID Nos. 656, 657, and 658,respectively)—positive PCR results indicate presence and orientation ofkan gene. Clones in both orientations were digested with PmeI andtransformed into BP913 with selection on yeast extract-peptone mediumsupplied with 1% (v/v) ethanol as carbon source and 200 μg/ml geneticin(G418). A single transformant was obtained, as confirmed by PCR (primersN886 and oBP264 for the 5′ end N1090 and oBP512 for the 3′ end, SEQ IDNos. 659, 646, 657, and 660, respectively). FIG. 6 depicts the locusafter integration of the plasmid.

Example 9 Construction of an Isobutanol-Producing Strain Carrying thePhosphoketolase Pathway

The strain described in Example 8 was transformed with 2 plasmidscontaining genes for an isobutanol pathway pYZ090 and pYZ067 (SEQ IDNOs: 1892 and 1891).

pYZ090 was constructed to contain a chimeric gene having the codingregion of the alsS gene from Bacillus subtilis (nt position 457-2172)expressed from the yeast CUP1 promoter (nt 2-449) and followed by theCYC1 terminator (nt 2181-2430) for expression of ALS, and a chimericgene having the coding region of the ilvC gene from Lactococcus lactis(nt 3634-4656) expressed from the yeast ILV5 promoter (2433-3626) andfollowed by the ILV5 terminator (nt 4682-5304) for expression of KARI.

pYZ067 was constructed to contain the following chimeric genes: 1) thecoding region of the ilvD gene from S. mutans UA159 with a C-terminalLumio tag (nt 2260-3972) expressed from the yeast FBA1 promoter (nt1661-2250) followed by the FBA1 terminator (nt 40005-4317) forexpression of dihydroxy acid dehydratase, 2) the coding region for horseliver ADH (nt 4680-5807) expressed from the yeast GPM1 promoter (nt5819-6575) followed by the ADH1 terminator (nt 4356-4671) for expressionof alcohol dehydrogenase, and 3) the coding region of the kivD gene fromLactococcus lactis (nt 7175-8821) expressed from the yeast TDH3 promoter(nt 8830-9493) followed by the TDH3 terminator (nt 6582-7161) forexpression of ketoisovalerate decarboxylase.

Transformants were obtained on synthetic complete medium lacking uraciland histidine with 1% (v/v) ethanol as carbon source and 100 μg/mlgeneticin. Control strains (BP913) were also transformed with the sameplasmids and plated without geneticin. A number of transformants werethen patched to the same medium containing 2% glucose as carbon sourceand supplemented with 0.05% (v/v) ethanol. After 36 hours, patches wereused to inoculate liquid medium (same composition as the plates). After48 hours, ODs for both phosphoketolase pathway and control strains weresimilar (ca. 4-50D) and all were subcultured into medium lacking ethanol(i.e. no exogenous two-carbon substrate source). The phosphoketolasecultures grew without ethanol supplementation, similar to ethanolsupplemented control strains. Results are shown in FIG. 7A (and Table17A). These were subcultured again to confirm growth rates, and resultsare shown in FIG. 7B (and Table 17B). Phosphoketolase strains appearedto have a decreased lag phase compared to controls, but the exponentialgrowth rates were not statistically different (average rate of 0.16h⁻¹).

TABLE 17A Condition Strain 0 h OD 18.3 h OD xpk ISO 1 0.1 2.3 xpk ISO 20.1 2.2 xpk ISO 3 0.1 2.2 ISO (no EtOH) 1 0.1 0.48 ISO (no EtOH) 2 0.10.41 ISO (no EtOH) 3 0.1 0.47 ISO (+EtOH) 1 0.1 2.5 ISO (+EtOH) 2 0.12.6 ISO (+EtOH) 3 0.1 2.4

TABLE 17B Condition 0 h 6.5 h 23 h 27 h 48 h Strain OD OD OD OD OD xpkISO 1 0.1 0.18 2.91 4 4.4 xpk ISO 2 0.1 0.14 1.54 2.88 4.6 xpk ISO 3 0.10.16 2.15 3.54 4.3 ISO (+EtOH) 1 0.1 0.14 2.21 3.46 4.4 ISO (+EtOH) 20.1 0.11 1.13 2.18 4.2 ISO (+EtOH) 3 0.1 0.1 0.84 1.6 4.4

Example 10 Construction of Saccharomyces cerevisiae Strain BP913

The purpose of this example is to describe the construction ofSaccharomyces cerevisiae strain BP913. The strain was derived fromCEN.PK 113-7D (CBS 8340; Centraalbureau voor Schimmelcultures (CBS)Fungal Biodiversity Centre, Netherlands) and contains deletions of thefollowing genes: URA3, HIS3, PDC1, PDC5, and PDC6.

Deletions, which completely removed the entire coding sequence, werecreated by homologous recombination with PCR fragments containingregions of homology upstream and downstream of the target gene andeither a G418 resistance marker or URA3 gene for selection oftransformants. The G418 resistance marker, flanked by loxP sites, wasremoved using Cre recombinase. The URA3 gene was removed by homologousrecombination to create a scarless deletion.

In general, the PCR cassette for each scarless deletion was made bycombining four fragments, A-B-U-C, by overlapping PCR. The PCR cassettecontained a selectable/counter-selectable marker, URA3 (Fragment U),consisting of the native CEN.PK 113-7D URA3 gene, along with thepromoter (250 bp upstream of the URA3 gene) and terminator (150 bpdownstream of the URA3 gene). Fragments A and C, each 500 bp long,corresponded to the 500 bp immediately upstream of the target gene(Fragment A) and the 3′ 500 bp of the target gene (Fragment C).Fragments A and C were used for integration of the cassette into thechromosome by homologous recombination. Fragment B (500 bp long)corresponded to the 500 bp immediately downstream of the target gene andwas used for excision of the URA3 marker and Fragment C from thechromosome by homologous recombination, as a direct repeat of thesequence corresponding to Fragment B was created upon integration of thecassette into the chromosome. Using the PCR product ABUC cassette, theURA3 marker was first integrated into and then excised from thechromosome by homologous recombination. The initial integration deletedthe gene, excluding the 3′ 500 bp. Upon excision, the 3′ 500 bp regionof the gene was also deleted. For integration of genes using thismethod, the gene to be integrated was included in the PCR cassettebetween fragments A and B.

URA3 Deletion

To delete the endogenous URA3 coding region, a ura3::loxP-kanMX-loxPcassette was PCR-amplified from pLA54 template DNA (SEQ ID NO: 661).pLA54 contains the K. lactis TEF 1 promoter and kanMX marker, and isflanked by loxP sites to allow recombination with Cre recombinase andremoval of the marker. PCR was done using Phusion DNA polymerase andprimers BK505 and BK506 (SEQ ID NOs:662 and 663). The URA3 portion ofeach primer was derived from the 5′ region upstream of the URA3 promoterand 3′ region downstream of the coding region such that integration ofthe loxP-kanMX-loxP marker resulted in replacement of the URA3 codingregion. The PCR product was transformed into CEN.PK 113-7D usingstandard genetic techniques (Methods in Yeast Genetics, 2005, ColdSpring Harbor Laboratory Press, Cold Spring Harbor, N.Y., pp. 201-202)and transformants were selected on YPD containing G418 (100 μg/ml) at 30C. Transformants were screened to verify correct integration by PCRusing primers LA468 and LA492 (SEQ ID NOs:664 and 665) and designatedCEN.PK 113-7D Δura3::kanMX.

HIS3 Deletion

The four fragments for the PCR cassette for the scarless HIS3 deletionwere amplified using Phusion High Fidelity PCR Master Mix (New EnglandBioLabs) and CEN.PK 113-7D genomic DNA as template, prepared with aGentra Puregene Yeast/Bact kit (Qiagen; Valencia, Calif.). HIS3 FragmentA was amplified with primer oBP452 (SEQ ID NO: 666) and primer oBP453(SEQ ID NO: 667), containing a 5′ tail with homology to the 5′ end ofHIS3 Fragment B. HIS3 Fragment B was amplified with primer oBP454 (SEQID NO: 668), containing a 5′ tail with homology to the 3′ end of HIS3Fragment A, and primer oBP455 (SEQ ID NO: 669), containing a 5′ tailwith homology to the 5′ end of HIS3 Fragment U. HIS3 Fragment U wasamplified with primer oBP456 (SEQ ID NO: 670), containing a 5′ tail withhomology to the 3′ end of HIS3 Fragment B, and primer oBP457 (SEQ ID NO:671), containing a 5′ tail with homology to the 5′ end of HIS3 FragmentC. HIS3 Fragment C was amplified with primer oBP458 (SEQ ID NO: 672),containing a 5′ tail with homology to the 3′ end of HIS3 Fragment U, andprimer oBP459 (SEQ ID NO: 673). PCR products were purified with a PCRPurification kit (Qiagen, Valencia, Calif.). HIS3 Fragment AB wascreated by overlapping PCR by mixing HIS3 Fragment A and HIS3 Fragment Band amplifying with primers oBP452 (SEQ ID NO: 666) and oBP455 (SEQ IDNO: 669). HIS3 Fragment UC was created by overlapping PCR by mixing HIS3Fragment U and HIS3 Fragment C and amplifying with primers oBP456 (SEQID NO: 670) and oBP459 (SEQ ID NO: 673). The resulting PCR products werepurified on an agarose gel followed by a Gel Extraction kit (Qiagen,Valencia, Calif.). The HIS3 ABUC cassette was created by overlapping PCRby mixing HIS3 Fragment AB and HIS3 Fragment UC and amplifying withprimers oBP452 (SEQ ID NO: 666) and oBP459 (SEQ ID NO: 673). The PCRproduct was purified with a PCR Purification kit (Qiagen, Valencia,Calif.).

Competent cells of CEN.PK 113-7D Δura3::kanMX were made and transformedwith the HIS3 ABUC PCR cassette using a Frozen-EZ Yeast TransformationII kit (Zymo Research, Orange, Calif.). Transformation mixtures wereplated on synthetic complete media lacking uracil supplemented with 2%glucose at 30 C. Transformants with a his3 knockout were screened for byPCR with primers oBP460 (SEQ ID NO: 674) and oBP461 (SEQ ID NO: 671)using genomic DNA prepared with a Gentra Puregene Yeast/Bact kit(Qiagen). A correct transformant was selected as strain CEN.PK 113-7DΔura3::kanMX Δhis3::URA3.

KanMX Marker Removal from the Δura3 Site and URA3 Marker Removal fromthe Δhis3 Site

The KanMX marker was removed by transforming CEN.PK 113-7D Δura3::kanMXΔhis3::URA3 with pRS423::PGAL1-cre (SEQ ID NO: 715) using a Frozen-EZYeast Transformation II kit (Zymo Research, Orange, Calif.) and platingon synthetic complete medium lacking histidine and uracil supplementedwith 2% glucose at 30 C. Transformants were grown in YP supplementedwith 1% galactose at 30 C for ˜6 hours to induce the Cre recombinase andKanMX marker excision and plated onto YPD (2% glucose) plates at 30 Cfor recovery. An isolate was grown overnight in YPD and plated onsynthetic complete medium containing 5-fluoro-orotic acid (0.1%) at 30 Cto select for isolates that lost the URA3 marker. 5-FOA resistantisolates were grown in and plated on YPD for removal of thepRS423::PGAL1-cre plasmid. Isolates were checked for loss of the KanMXmarker, URA3 marker, and pRS423::PGAL1-cre plasmid by assaying growth onYPD+G418 plates, synthetic complete medium lacking uracil plates, andsynthetic complete medium lacking histidine plates. A correct isolatethat was sensitive to G418 and auxotrophic for uracil and histidine wasselected as strain CEN.PK 113-7D Δura3::loxP Δhis3 and designated asBP857. The deletions and marker removal were confirmed by PCR andsequencing with primers oBP450 (SEQ ID NO: 676) and oBP451 (SEQ ID NO:677) for Δura3 and primers oBP460 (SEQ ID NO: 674) and oBP461 (SEQ IDNO: 675) for Δhis3 using genomic DNA prepared with a Gentra PuregeneYeast/Bact kit (Qiagen, Valencia, Calif.).

PDC6 Deletion

The four fragments for the PCR cassette for the scarless PDC6 deletionwere amplified using Phusion High Fidelity PCR Master Mix (New EnglandBioLabs, Ipswich, Mass.) and CEN.PK 113-7D genomic DNA as template,prepared with a Gentra Puregene Yeast/Bact kit (Qiagen). PDC6 Fragment Awas amplified with primer oBP440 (SEQ ID NO: 670) and primer oBP441 (SEQID NO: 679), containing a 5′ tail with homology to the 5′ end of PDC6Fragment B. PDC6 Fragment B was amplified with primer oBP442 (SEQ ID NO:680), containing a 5′ tail with homology to the 3′ end of PDC6 FragmentA, and primer oBP443 (SEQ ID NO: 681), containing a 5′ tail withhomology to the 5′ end of PDC6 Fragment U. PDC6 Fragment U was amplifiedwith primer oBP444 (SEQ ID NO: 682), containing a 5′ tail with homologyto the 3′ end of PDC6 Fragment B, and primer oBP445 (SEQ ID NO: 683),containing a 5′ tail with homology to the 5′ end of PDC6 Fragment C.PDC6 Fragment C was amplified with primer oBP446 (SEQ ID NO: 684),containing a 5′ tail with homology to the 3′ end of PDC6 Fragment U, andprimer oBP447 (SEQ ID NO: 685). PCR products were purified with a PCRPurification kit (Qiagen). PDC6 Fragment AB was created by overlappingPCR by mixing PDC6 Fragment A and PDC6 Fragment B and amplifying withprimers oBP440 (SEQ ID NO: 678) and oBP443 (SEQ ID NO: 681). PDC6Fragment UC was created by overlapping PCR by mixing PDC6 Fragment U andPDC6 Fragment C and amplifying with primers oBP444 (SEQ ID NO: 682) andoBP447 (SEQ ID NO: 685). The resulting PCR products were purified on anagarose gel followed by a Gel Extraction kit (Qiagen). The PDC6 ABUCcassette was created by overlapping PCR by mixing PDC6 Fragment AB andPDC6 Fragment UC and amplifying with primers oBP440 (SEQ ID NO: 678) andoBP447 (SEQ ID NO: 685). The PCR product was purified with a PCRPurification kit (Qiagen).

Competent cells of CEN.PK 113-7D Δura3::loxP Δhis3 were made andtransformed with the PDC6 ABUC PCR cassette using a Frozen-EZ YeastTransformation II kit (Zymo Research). Transformation mixtures wereplated on synthetic complete media lacking uracil supplemented with 2%glucose at 30 C. Transformants with a pdc6 knockout were screened for byPCR with primers oBP448 (SEQ ID NO: 686) and oBP449 (SEQ ID NO: 687)using genomic DNA prepared with a Gentra Puregene Yeast/Bact kit(Qiagen). A correct transformant was selected as strain CEN.PK 113-7DΔura3::loxP Δhis3 Δpdc6::URA3.

CEN.PK 113-7D Δura3::loxP Δhis3 Δpdc6::URA3 was grown overnight in YPDand plated on synthetic complete medium containing 5-fluoro-orotic acid(0.1%) at 30 C to select for isolates that lost the URA3 marker. Thedeletion and marker removal were confirmed by PCR and sequencing withprimers oBP448 (SEQ ID NO: 686) and oBP449 (SEQ ID NO: 687) usinggenomic DNA prepared with a Gentra Puregene Yeast/Bact kit (Qiagen). Theabsence of the PDC6 gene from the isolate was demonstrated by a negativePCR result using primers specific for the coding sequence of PDC6,oBP554 (SEQ ID NO: 688) and oBP555 (SEQ ID NO: 689). The correct isolatewas selected as strain CEN.PK 113-7D Δura3::loxP Δhis3 Δpdc6 anddesignated as BP891.

PDC1 Deletion ilvDSm Integration

The PDC1 gene was deleted and replaced with the ilvD coding region fromStreptococcus mutans ATCC #700610 (SEQ ID NO: 1886). The A fragmentfollowed by the ilvD coding region from Streptococcus mutans for the PCRcassette for the PDC 1 deletion-ilvDSm integration was amplified usingPhusion High Fidelity PCR Master Mix (New England BioLabs) and NYLA83genomic DNA as template (construction of strain NYLA83 is described inU.S. Application Pub. No. 20110124060 A1, incorporated herein byreference), prepared with a Gentra Puregene Yeast/Bact kit (Qiagen).PDC1 Fragment A-ilvDSm was amplified with primer oBP513 (SEQ ID NO: 690)and primer oBP515 (SEQ ID NO: 691), containing a 5′ tail with homologyto the 5′ end of PDC1 Fragment B. The B, U, and C fragments for the PCRcassette for the PDC1 deletion-ilvDSm integration were amplified usingPhusion High Fidelity PCR Master Mix (New England BioLabs) and CEN.PK113-7D genomic DNA as template, prepared with a Gentra PuregeneYeast/Bact kit (Qiagen). PDC1 Fragment B was amplified with primeroBP516 (SEQ ID NO: 692), containing a 5′ tail with homology to the 3′end of PDC1 Fragment A-ilvDSm, and primer oBP517 (SEQ ID NO: 693),containing a 5′ tail with homology to the 5′ end of PDC1 Fragment U.PDC1 Fragment U was amplified with primer oBP518 (SEQ ID NO: 694),containing a 5′ tail with homology to the 3′ end of PDC1 Fragment B, andprimer oBP519 (SEQ ID NO: 695), containing a 5′ tail with homology tothe 5′ end of PDC1 Fragment C. PDC1 Fragment C was amplified with primeroBP520 (SEQ ID NO: 696), containing a 5′ tail with homology to the 3′end of PDC1 Fragment U, and primer oBP521 (SEQ ID NO: 697). PCR productswere purified with a PCR Purification kit (Qiagen). PDC1 FragmentA-ilvDSm-B was created by overlapping PCR by mixing PDC1 FragmentA-ilvDSm and PDC1 Fragment B and amplifying with primers oBP513 (SEQ IDNO: 690) and oBP517 (SEQ ID NO: 693). PDC1 Fragment UC was created byoverlapping PCR by mixing PDC1 Fragment U and PDC1 Fragment C andamplifying with primers oBP518 (SEQ ID NO: 694) and oBP521 (SEQ ID NO:697). The resulting PCR products were purified on an agarose gelfollowed by a Gel Extraction kit (Qiagen). The PDC1 A-ilvDSm-BUCcassette was created by overlapping PCR by mixing PDC1 FragmentA-ilvDSm-B and PDC1 Fragment UC and amplifying with primers oBP513 (SEQID NO: 690) and oBP521 (SEQ ID NO: 697). The PCR product was purifiedwith a PCR Purification kit (Qiagen).

Competent cells of CEN.PK 113-7D Δura3::loxP Δhis3 Δpdc6 were made andtransformed with the PDC1 A-ilvDSm-BUC PCR cassette using a Frozen-EZYeast Transformation II kit (Zymo Research). Transformation mixtureswere plated on synthetic complete media lacking uracil supplemented with2% glucose at 30 C. Transformants with a pdc1 knockout ilvDSmintegration were screened for by PCR with primers oBP511 (SEQ ID NO:698) and oBP512 (SEQ ID NO: 699) using genomic DNA prepared with aGentra Puregene Yeast/Bact kit (Qiagen). The absence of the PDC1 genefrom the isolate was demonstrated by a negative PCR result using primersspecific for the coding sequence of PDC1, oBP550 (SEQ ID NO: 700) andoBP551 (SEQ ID NO: 701). A correct transformant was selected as strainCEN.PK 113-7D Δura3::loxP Δhis3 Δpdc6 Δpdc1::ilvDSm-URA3.

CEN.PK 113-7D Δura3::loxP Δhis3 Δpdc6 Δpdc1::ilvDSm-URA3 was grownovernight in YPD and plated on synthetic complete medium containing5-fluoro-orotic acid (0.1%) at 30 C to select for isolates that lost theURA3 marker. The deletion of PDC1, integration of ilvDSm, and markerremoval were confirmed by PCR and sequencing with primers oBP511 (SEQ IDNO: 698) and oBP512 (SEQ ID NO: 699) using genomic DNA prepared with aGentra Puregene Yeast/Bact kit (Qiagen). The correct isolate wasselected as strain CEN.PK 113-7D Δura3::loxP Δhis3 Δpdc6 Δpdc1::ilvDSmand designated as BP907.

PDC5 Deletion sadB Integration

The PDC5 gene was deleted and replaced with the sadB coding region fromAchromobacter xylosoxidans. A segment of the PCR cassette for the PDC5deletion-sadB integration was first cloned into plasmid pUC19-URA3MCS(described in Example 2). The coding sequence of sadB (SEQ ID NO: 718)and PDC5 Fragment B were cloned into pUC19-URA3MCS to create the sadB-BUportion of the PDC5 A-sadB-BUC PCR cassette. The coding sequence of sadBwas amplified using pLH468-sadB (SEQ ID NO: 716) as template with primeroBP530 (SEQ ID NO: 702), containing an AscI restriction site, and primeroBP531 (SEQ ID NO: 703), containing a 5′ tail with homology to the 5′end of PDC5 Fragment B. PDC5 Fragment B was amplified from CEN.PK 113-7Dgenomic DNA with primer oBP532 (SEQ ID NO: 704), containing a 5′ tailwith homology to the 3′ end of sadB, and primer oBP533 (SEQ ID NO: 705),containing a PmeI restriction site. PCR products were purified with aPCR Purification kit (Qiagen). sadB-PDC5 Fragment B was created byoverlapping PCR by mixing the sadB and PDC5 Fragment B PCR products andamplifying with primers oBP530 (SEQ ID NO: 702) and oBP533 (SEQ ID NO:705). The resulting PCR product was digested with AscI and PmeI andligated with T4 DNA ligase into the corresponding sites of pUC19-URA3MCSafter digestion with the appropriate enzymes. The resulting plasmid wasused as a template for amplification of sadB-Fragment B-Fragment U usingprimers oBP536 (SEQ ID NO: 706) and oBP546 (SEQ ID NO: 707), containinga 5′ tail with homology to the 5′ end of PDC5 Fragment C. PDC5 FragmentC was amplified from CEN.PK 113-7D genomic DNA with primer oBP547 (SEQID NO: 708), containing a 5′ tail with homology to the 3′ end of PDC5sadB-Fragment B-Fragment U, and primer oBP539 (SEQ ID NO: 709). PCRproducts were purified with a PCR Purification kit (Qiagen). PDC5sadB-Fragment B-Fragment U-Fragment C was created by overlapping PCR bymixing PDC5 sadB-Fragment B-Fragment U and PDC5 Fragment C andamplifying with primers oBP536 (SEQ ID NO: 706) and oBP539 (SEQ ID NO:709). The resulting PCR product was purified on an agarose gel followedby a Gel Extraction kit (Qiagen). The PDC5 A-sadB-BUC cassette wascreated by amplifying PDC5 sadB-Fragment B-Fragment U-Fragment C withprimers oBP542 (SEQ ID NO: 710) containing a 5′ tail with homology tothe 50 nucleotides immediately upstream of the native PDC5 codingsequence, and oBP539 (SEQ ID NO: 709). The PCR product was purified witha PCR Purification kit (Qiagen).

Competent cells of CEN.PK 113-7D Δura3::loxP Δhis3 Δpdc6 Δpdc1::ilvDSmwere made and transformed with the PDC5 A-sadB-BUC PCR cassette using aFrozen-EZ Yeast Transformation II kit (Zymo Research). Transformationmixtures were plated on synthetic complete media lacking uracilsupplemented with 1% ethanol (no glucose) at 30 C. Transformants with apdc5 knockout sadB integration were screened for by PCR with primersoBP540 (SEQ ID NO: 711) and oBP541 (SEQ ID NO: 712) using genomic DNAprepared with a Gentra Puregene Yeast/Bact kit (Qiagen). The absence ofthe PDC5 gene from the isolate was demonstrated by a negative PCR resultusing primers specific for the coding sequence of PDC5, oBP552 (SEQ IDNO: 713) and oBP553 (SEQ ID NO: 714). A correct transformant wasselected as strain CEN.PK 113-7D Δura3::loxP Δhis3 Δpdc6 Δpdc1::ilvDSmΔpdc5::sadB-URA3.

CEN.PK 113-7D Δura3::loxP Δhis3 Δpdc6 Δpdc1::ilvDSm Δpdc5::sadB-URA3 wasgrown overnight in YPE (1% ethanol) and plated on synthetic completemedium supplemented with ethanol (no glucose) and containing5-fluoro-orotic acid (0.1%) at 30 C to select for isolates that lost theURA3 marker. The deletion of PDC5, integration of sadB, and markerremoval were confirmed by PCR with primers oBP540 (SEQ ID NO: 711) andoBP541 (SEQ ID NO: 712) using genomic DNA prepared with a GentraPuregene Yeast/Bact kit (Qiagen). The correct isolate was selected asstrain CEN.PK 113-7D Δura3::loxP Δhis3 Δpdc6 Δpdc1::ilvDSm Δpdc5::sadBand designated as BP913.

Example 11 Construction of Strain NYLA83

This example describes insertion-inactivation of endogenous PDC1 andPDC6 genes of S. cerevisiae. PDC1, PDC5, and PDC6 genes encode the threemajor isozymes of pyruvate decarboxylase. The resulting strain was usedas described in Example 10.

Construction of pRS425::GPM-sadB

A DNA fragment encoding a butanol dehydrogenase (SEQ ID NO: 717) fromAchromobacter xylosoxidans (disclosed in US Patent ApplicationPublication No. US20090269823) was cloned. The coding region of thisgene called sadB for secondary alcohol dehydrogenase (SEQ ID NO: 718)was amplified using standard conditions from A. xylosoxidans genomicDNA, prepared using a Gentra Puregene kit (Gentra Systems, Inc.,Minneapolis, Minn.; catalog number D-5500A) following the recommendedprotocol for gram negative organisms using forward and reverse primersN473 and N469 (SEQ ID NOs:725 and 726), respectively. The PCR productwas TOPO-Blunt cloned into pCR4 BLUNT (Invitrogen) to producepCR4Blunt::sadB, which was transformed into E. coli Mach-1 cells.Plasmid was subsequently isolated from four clones, and the sequenceverified.

The sadB coding region was PCR amplified from pCR4Blunt::sadB. PCRprimers contained additional 5′ sequences that would overlap with theyeast GPM1 promoter and the ADH1 terminator (N583 and N584, provided asSEQ ID NOs:727 and 728). The PCR product was then cloned using “gaprepair” methodology in Saccharomyces cerevisiae (Ma et al. ibid) asfollows. The yeast-E. coli shuttle vector pRS425::GPM::kivD::ADH whichcontains the GPM1 promoter (SEQ ID NO:721), kivD coding region fromLactococcus lactis (SEQ D NO:719), and ADH1 terminator (SEQ ID NO:722)(described in U.S. Pat. No. 7,851,188, Example 17) was digested withBbvCI and Pad restriction enzymes to release the kivD coding region.Approximately 1 μg of the remaining vector fragment was transformed intoS. cerevisiae strain BY4741 along with 1 μg of sadB PCR product.Transformants were selected on synthetic complete medium lackingleucine. The proper recombination event, generating pRS425::GPM-sadB,was confirmed by PCR using primers N142 and N459 (SEQ ID NOs:729 and730).

Construction of pdc6:: P_(GPM1)-sadB Integration Cassette and PDC6Deletion:

A pdc6::P_(GPM1)-sadB-ADH1t-URA3r integration cassette was made byjoining the GPM-sadB-ADHt segment (SEQ ID NO:723) from pRS425::GPM-sadB(SEQ ID NO: 720) to the URA3r gene from pUC19-URA3r. pUC19-URA3r (SEQ IDNO:724) contains the URA3 marker from pRS426 (ATCC #77107) flanked by 75bp homologous repeat sequences to allow homologous recombination in vivoand removal of the URA3 marker. The two DNA segments were joined by SOEPCR (as described by Horton et al. (1989) Gene 77:61-68) using astemplate pRS425::GPM-sadB and pUC19-URA3r plasmid DNAs, with Phusion DNApolymerase (New England Biolabs Inc., Beverly, Mass.; catalog no.F-5405) and primers 114117-11A through 114117-11D (SEQ ID NOs:731, 732,733 and 734), and 114117-13A and 114117-13B (SEQ ID NOs:735 and 736).

The outer primers for the SOE PCR (114117-13A and 114117-13B) contained5′ and 3′ ˜50 bp regions homologous to regions upstream and downstreamof the PDC6 promoter and terminator, respectively. The completedcassette PCR fragment was transformed into BY4700 (ATCC #200866) andtransformants were maintained on synthetic complete media lacking uraciland supplemented with 2% glucose at 30° C. using standard genetictechniques (Methods in Yeast Genetics, 2005, Cold Spring HarborLaboratory Press, Cold Spring Harbor, N.Y., pp. 201-202). Transformantswere screened by PCR using primers 112590-34G and 112590-34H (SEQ IDNOs:737 and 738), and 112590-34F and 112590-49E (SEQ ID NOs: 739 and740) to verify integration at the PDC6 locus with deletion of the PDC6coding region. The URA3r marker was recycled by plating on syntheticcomplete media supplemented with 2% glucose and 5-FOA at 30° C.following standard protocols. Marker removal was confirmed by patchingcolonies from the 5-FOA plates onto SD −URA media to verify the absenceof growth. The resulting identified strain has the genotype: BY4700pdc6::P_(GPM1)-sadB-ADH1t.

Construction of pdc1::P_(PDC1)-ilvD Integration Cassette and PDC1Deletion:

A pdc1:: P_(PDC1)-ilvD-FBA1t-URA3r integration cassette was made byjoining the ilvD-FBA1t segment (SEQ ID NO:741) from pLH468 (SEQ ID NO:1888) to the URA3r gene from pUC19-URA3r by SOE PCR (as described byHorton et al. (1989) Gene 77:61-68) using as template pLH468 andpUC19-URA3r plasmid DNAs, with Phusion DNA polymerase (New EnglandBiolabs Inc., Beverly, Mass.; catalog no. F-540S) and primers 114117-27Athrough 114117-27D (SEQ ID NOs:742, 743, 744 and 745).

The outer primers for the SOE PCR (114117-27A and 114117-27D) contained5′ and 3′ ˜50 bp regions homologous to regions downstream of the PDC1promoter and downstream of the PDC1 coding sequence. The completedcassette PCR fragment was transformed into BY4700pdc6::P_(GPM1)-sadB-ADH1t and transformants were maintained on syntheticcomplete media lacking uracil and supplemented with 2% glucose at 30° C.using standard genetic techniques (Methods in Yeast Genetics, 2005, ColdSpring Harbor Laboratory Press, Cold Spring Harbor, N.Y., pp. 201-202).Transformants were screened by PCR using primers 114117-36D and 135 (SEQID NOs 746 and 747), and primers 112590-49E and 112590-30F (SEQ ID NOs740 and 748) to verify integration at the PDC1 locus with deletion ofthe PDC1 coding sequence. The URA3r marker was recycled by plating onsynthetic complete media supplemented with 2% glucose and 5-FOA at 30°C. following standard protocols. Marker removal was confirmed bypatching colonies from the 5-FOA plates onto SD −URA media to verify theabsence of growth. The resulting identified strain “NYLA67” has thegenotype: BY4700 pdc6:: P_(GPM1)-sadB-ADH1t pdc1::_P_(PDC1)-ilvD-FBA1t.

HIS3 Deletion

To delete the endogenous HIS3 coding region, a his3::URA3r2 cassette wasPCR-amplified from URA3r2 template DNA (SEQ ID NO: 749). URA3r2 containsthe URA3 marker from pRS426 (ATCC #77107) flanked by 500 bp homologousrepeat sequences to allow homologous recombination in vivo and removalof the URA3 marker. PCR was done using Phusion DNA polymerase andprimers 114117-45A and 114117-45B (SEQ ID NOs:750 and 751) whichgenerated a ˜2.3 kb PCR product. The HIS3 portion of each primer wasderived from the 5′ region upstream of the HIS3 promoter and 3′ regiondownstream of the coding region such that integration of the URA3r2marker results in replacement of the HIS3 coding region. The PCR productwas transformed into NYLA67 using standard genetic techniques (Methodsin Yeast Genetics, 2005, Cold Spring Harbor Laboratory Press, ColdSpring Harbor, N.Y., pp. 201-202) and transformants were selected onsynthetic complete media lacking uracil and supplemented with 2% glucoseat 30° C. Transformants were screened to verify correct integration byreplica plating of transformants onto synthetic complete media lackinghistidine and supplemented with 2% glucose at 30° C. The URA3r markerwas recycled by plating on synthetic complete media supplemented with 2%glucose and 5-FOA at 30° C. following standard protocols. Marker removalwas confirmed by patching colonies from the 5-FOA plates onto SD −URAmedia to verify the absence of growth. The resulting identified strain,called NYLA73, has the genotype: BY4700 pdc6:: P_(GPM1)-sadB-ADH1tpdc1:: P_(PDC1)-ilvD-FBA1t Δhis3.

Construction of pdc5::kanMX Integration Cassette and PDC5 Deletion:

A pdc5::kanMX4 cassette was PCR-amplified from strain YLR134Wchromosomal DNA (ATCC No. 4034091) using Phusion DNA polymerase andprimers PDC5::KanMXF and PDC5::KanMXR (SEQ ID NOs:752 and 753) whichgenerated a ˜2.2 kb PCR product. The PDC5 portion of each primer wasderived from the 5′ region upstream of the PDC5 promoter and 3′ regiondownstream of the coding region such that integration of the kanMX4marker results in replacement of the PDC5 coding region. The PCR productwas transformed into NYLA73 using standard genetic techniques (Methodsin Yeast Genetics, 2005, Cold Spring Harbor Laboratory Press, ColdSpring Harbor, N.Y., pp. 201-202) and transformants were selected on YPmedia supplemented with 1% ethanol and geneticin (200 μg/ml) at 30° C.Transformants were screened by PCR to verify correct integration at thePDC locus with replacement of the PDC5 coding region using primersPDC5kofor and N175 (SEQ ID NOs: 754 and 755). The identified correcttransformants have the genotype: BY4700 pdc6:: P_(GPM1)-sadB-ADH1tpdc1:: P_(PDC1)-ilvD-FBA1t Δhis3 pdc5::kanMX4. The strain was namedNYLA74.

Deletion of HXK2 (Hexokinase II):

A hxk2::URA3r cassette was PCR-amplified from URA3r2 template (describedabove) using Phusion DNA polymerase and primers 384 and 385 (SEQ IDNOs:756 and 757) which generated a ˜2.3 kb PCR product. The HXK2 portionof each primer was derived from the 5′ region upstream of the HXK2promoter and 3′ region downstream of the coding region such thatintegration of the URA3r2 marker results in replacement of the HXK2coding region. The PCR product was transformed into NYLA73 usingstandard genetic techniques (Methods in Yeast Genetics, 2005, ColdSpring Harbor Laboratory Press, Cold Spring Harbor, N.Y., pp. 201-202)and transformants were selected on synthetic complete media lackinguracil and supplemented with 2% glucose at 30° C. Transformants werescreened by PCR to verify correct integration at the HXK2 locus withreplacement of the HXK2 coding region using primers N869 and N871 (SEQID NOs:758 and 759). The URA3r2 marker was recycled by plating onsynthetic complete media supplemented with 2% glucose and 5-FOA at 30°C. following standard protocols. Marker removal was confirmed bypatching colonies from the 5-FOA plates onto SD −URA media to verify theabsence of growth, and by PCR to verify correct marker removal usingprimers N946 and N947 (SEQ ID NOs:760 and 761). The resulting identifiedstrain named NYLA83 has the genotype: BY4700 pdc6:: P_(GPM1)-sadB-ADH1tpdc1:: P_(PDC1)-ilvD-FBA1t Δhis3 Δhxk2.

Example 12 Construction of Saccharomyces cerevisiae Strain PNY2257

Strain PNY2242 was constructed in several steps from BP913 (describedabove). First, the native GPD2 gene on Chromsome XV was deleted. Thecoding region was deleted using CRE-lox mediated marker removal(methodology described above), so the resulting locus contains one loxPsite. The sequence of the modified locus is provided as SEQ ID NO: 1899(Upstream region=nt 1-500; loxP site=nt 531-564; Downstream region=nt616-1115). Second, the native FRA2 gene on Chromosome VII was deleted.Elimination of FRA2 was a scarless deletion of only the coding region.The sequence of the modified locus is provided as SEQ ID NO: 1900(Upstream region=nt 1-501; Downstream region=nt 526-1025). Next, theADH1 gene on Chromosome XV was deleted along with insertion of achimeric gene comprised of the UAS(PGK1)—FBA1 promoter and the kivDcoding region. The native ADH1 terminator was used to complete the gene.The sequence of the modified locus is provided as SEQ ID No. 1901(Upstream region=nt 1-500; UAS(PGK1)FBA promoter=nt 509-1233; kivDcoding region=nt 1242-2888; Downstream region (includes terminator)=nt2889-3388). Next, a chimeric gene comprised of the FBA1 promoter, thealsS coding region and the CYC1 terminator was integrated intoChromosome XII, upstream of the TRX1 gene. The sequence of the modifiedlocus is provided as SEQ ID No. 1902(Upstream region=nt 1-154; FBA1promoter=nt 155-802; alsS CDS=nt 810-2525; CYC1 terminator=nt 2534-2788;Downstream region=nt 2790-3015). Next, two copies of a gene encodinghorse liver alcohol dehydrogenase were integrated into Chromsomes VIIand XVI. On Chromosome VII, a chimeric gene comprised of the PDC1promoter, the hADH coding region and the ADH1 terminator were placedinto the fra2Δ locus (the original deletion of FRA2 is described above).The sequence of the modified locus is provided as SEQ ID No. 1903(Upstream region=nt 1-300; PDC1 promoter=nt 309-1178; hADH codingregion=nt 1179-2306; ADH1 terminator=nt 2315-2630; Downstream region=nt2639-2900). On Chromosome XVI, a chimeric gene comprised of the PDC5promoter, the hADH coding region and the ADH1 terminator were integratedin the region formerly occupied by the long term repeat elementYPRCdelta15. The sequence of the modified locus is provided as SEQ IDNo. 1904 (Upstream region=nt 1-150; PDC5 promoter=nt 159-696; hADHcoding region=nt 697-1824; ADH1 terminator=nt 1833-2148; Downstreamregion=nt 2157-2656). Then the native genes YMR226c and ALD6 weredeleted. Elimination of YMR226c was a scarless deletion of only thecoding region. The sequence of the modified locus is provided as SEQ IDNo. 1905 (Upstream region=nt 1-250; Downstream region=nt 251-451). TheALD6 coding region plus 700 bp of upstream sequence were deleted usingCRE-lox mediated marker removal, so the resulting locus contains oneloxP site. The sequence of the modified locus is provided as SEQ ID No.1906(Upstream region=nt 1-500; loxP site=nt 551-584; Downstreamregion=nt 678-1128). The geneticin-selectable phosphoketolase expressionvector described in Example 8 was transformed into the strain andconfirmed as described above (the locus is depicted in FIG. 6). Finally,plasmids were introduced into the strain for expression of KARI (pLH702,plasmid SEQ ID. No. 1907) and DHAD (pYZ067DkivDDhADH, SEQ ID. No. 1908),resulting in the strain named PNY2257. A control strain containing allof the elements above except for the phosphoketolase pathway constructis called PNY2242.

Growth rates were assessed as described in previous examples. Over a 24hour period, PNY2257 displayed growth rates without ethanol or othertwo-carbon supplement similar to those growth rates observed for PNY2242with supplementation.

TABLE 6 HMMER2.0 [2.2g] NAME XFP_XPK_exp_seqs LENG 845 ALPH Amino RF noCS no MAP yes COM /app/public/hmmer/current/bin/hmmbuild XFP_XPK_HMMXFP_XPK_exp_seqs.aln COM /app/public/hmmer/current/bin/hmmcalibrate--mean 800 XFP_XPK_HMM NSEQ 8 DATE Fri Dec 4 15:29:49 2009 CKSUM 6589 XT−8455 −4 −1000 −1000 −8455 −4 −8455 −4 NULT −4 −8455 NULE 595 −1558 85338 −294 453 −1158 197 249 902 −1085 −142 −21 −313 45 531 201 384 −1998−644 EVD −614.573792 0.077043 A C D E F G H I K HMM m->m m->i m->d i->mi->i d->m d->d b->m m->e L M N P Q R S T V W Y −476 * −1831  1(M) −579−646 −1823 −1279 −241 −1949 −816 340 −991 1145 2778 −1234 1286 −828−1131 −1025 −537 205 −1033 −696 11 — −149 −500 233 43 −381 399 106 −626210 −466 −720 275 394 45 96 359 117 −369 −294 −249 — −25 −6428 −7470−894 −1115 −701 −1378 −476 *  2(W) −424 −1143 −649 −112 −1118 −1430 −73−944 1343 −1091 −364 −285 1428 217 174 −480 −363 −730 3083 −756 12 —−149 −500 233 43 −381 399 106 −626 210 −466 −720 275 394 45 96 359 117−369 −294 −249 — −25 −6428 −7470 −894 −1115 −701 −1378 * *  3(Q) −411−1812 202 1278 −2120 997 53 −1844 1011 −1806 −940 170 −1370 1483 39 −277−358 −1435 −1985 −1327 13 — −149 −500 233 43 −381 399 106 −626 210 −466−720 275 394 45 96 359 117 −369 −294 −249 — −25 −6428 −7470 −894 −1115−701 −1378 * *  4(M) −554 −1770 −500 1294 −2084 −1496 −45 −1741 1490−1726 2375 −163 −1571 384 1179 −467 −467 −1393 −1906 −1358 14 — −149−500 233 43 −381 399 106 −626 210 −466 −720 275 394 45 96 359 117 −369−294 −249 — −19 −6836 −7878 −894 −1115 −701 −1378 * *  5(V) 582 −614−1167 546 −657 −1623 −419 −47 −453 583 188 −696 −1707 −324 −741 −630 7731221 −1069 −649 15 — −149 −500 233 43 −381 399 106 −626 210 −466 −720275 394 45 96 359 117 −369 −294 −249 — −19 −6836 −7878 −894 −1115 −701−1378 * *  6(M) −388 −632 233 −716 −648 −1697 −471 1170 −550 −499 1779218 −1768 −407 −821 −698 1278 799 −1059 −646 16 — −149 −500 233 43 −381399 106 −626 210 −466 −720 275 394 45 96 359 117 −369 −294 −249 — −17−7025 −8067 −894 −1115 −701 −1378 * *  7(D) 54 −2137 2020 1380 −2436−1385 −196 −2201 126 −2144 −1250 1219 −1583 239 702 −471 −581 −1750−2320 −1600 17 — −149 −500 233 43 −381 399 106 −626 210 −466 −720 275394 45 96 359 117 −369 −294 −249 — −17 −7025 −8067 −894 −1115 −701−1378 * *  8(Y) −508 −822 −1280 −702 −673 −1748 −430 832 −332 −675 −3−776 809 −344 1190 −762 −446 −274 −1076 2458 18 — −149 −500 233 43 −381399 106 −626 210 −466 −720 275 394 45 96 359 117 −369 −294 −249 — −17−7025 −8067 −894 −1115 −701 −1378 * *  9(D) −469 −1542 1605 42 −1969−1375 −320 −1627 −36 −1747 −919 −219 1080 65 −522 1153 −479 670 −2048−1444 19 — −149 −500 233 43 −381 399 106 −626 210 −466 −720 275 394 4596 359 117 −369 −294 −249 — −17 −7025 −8067 −894 −1115 −701 −1378 * * 10(S) −586 −1385 −736 −829 −2829 −1309 −1317 −2735 −1241 −2859 −20471835 −1910 −1051 −1602 2833 −881 −1997 −2969 −2410 20 — −149 −500 233 43−381 399 106 −626 210 −466 −720 275 394 45 96 359 117 −369 −294 −249 —−17 −7025 −8067 −894 −1115 −701 −1378 * *  11(P) −526 −1890 −212 1174−2213 −1420 −120 −1928 1548 −1905 −1024 −80 1551 317 −111 −415 763 −1521−2093 −1450 21 — −149 −500 233 43 −381 399 106 −626 210 −466 −720 275394 45 96 359 117 −369 −294 −249 — −17 −7025 −8067 −894 −1115 −701−1378 * *  12(D) 1339 −2192 1728 1307 −2485 −1401 −248 −2248 996 −2199−1317 −28 −1622 180 −495 −529 −648 −1804 −2382 −1658 22 — −149 −500 23343 −381 399 106 −626 210 −466 −720 275 394 45 96 359 117 −369 −294 −249— −17 −7025 −8067 −894 −1115 −701 −1378 * *  13(Y) 984 −983 −1421 −1092−837 −1586 −819 −1015 −973 −1266 −608 −1029 1341 −855 −1218 −770 −660−790 −1317 3268 23 — −149 −500 233 43 −381 399 106 −626 210 −466 −720275 394 45 96 359 117 −369 −294 −249 — −17 −7025 −8067 −894 −1115 −701−1378 * *  14(L) −877 −775 −2589 −1991 1160 −2382 −1170 1029 960 1849533 −1790 −2366 −1386 −1652 −1454 −810 77 −1124 −783 24 — −149 −500 23343 −381 399 106 −626 210 −466 −720 275 394 45 96 359 117 −369 −294 −249— −17 −7025 −8067 −894 −1115 −701 −1378 * *  15(N) −730 −2232 123 1772−2530 −1420 −275 −2293 34 −2239 −1364 1865 1127 1325 −496 −569 −693−1850 −2418 −1697 25 — −149 −500 233 43 −381 399 106 −626 210 −466 −720275 394 45 96 359 117 −369 −294 −249 — −17 −7025 −8067 −894 −1115 −701−1378 * *  16(S) −406 −1619 −309 191 −1903 406 −102 −1593 986 −317 −7891064 −1504 317 −181 1301 −358 −1237 −1903 −1286 26 — −149 −500 233 43−381 399 106 −626 210 −466 −720 275 394 45 96 359 117 −369 −294 −249 —−17 −7025 −8067 −894 −1115 −701 −1378 * *  17(M) −675 −566 −2528 −1928−364 −2184 2126 218 −1592 743 2772 −1654 −2210 −1313 −1560 −1256 −6141711 −990 −635 27 — −149 −500 233 43 −381 399 106 −626 210 −466 −720 275394 45 96 359 117 −369 −294 −249 — −16 −7108 −8150 −894 −1115 −701−1378 * *  18(D) −749 −1575 2786 −299 −2062 −1566 −768 −1153 −635 −1769−1097 −535 −1902 −450 −1112 −799 731 1070 −2328 −1751 28 — −149 −500 23343 −381 399 106 −626 210 −466 −720 275 394 45 96 359 117 −369 −294 −249— −16 −7108 −8150 −894 −1115 −701 −1378 * *  19(K) 1232 −1674 −736 −295−2360 −1534 −473 −2014 2326 −2058 −1228 −486 1165 −74 −221 −634 −677−1596 −2264 −1735 29 — −149 −500 233 43 −381 399 106 −626 210 −466 −720275 394 45 96 359 117 −369 −294 −249 — −16 −7108 −8150 −894 −1115 −701−1378 * *  20(Y) −2075 −2643 1686 −985 −266 −2358 −869 −2644 −1801 −2467−2120 −1177 −2732 −1384 −2229 −1931 −2114 −2488 −905 4141 30 — −149 −500233 43 −381 399 106 −626 210 −466 −720 275 394 45 96 359 117 −369 −294−249 — −16 −7108 −8150 −894 −1115 −701 −1378 * *  21(W) −2473 −2122−3795 −3534 136 −3469 −1296 −944 −2887 1176 −449 −2889 −3469 −2568 −2708−2895 −2429 −1317 5419 316 31 — −149 −500 233 43 −381 399 106 −626 210−466 −720 275 394 45 96 359 117 −369 −294 −249 — −16 −7108 −8150 −894−1115 −701 −1378 * *  22(R) −1335 −1772 −2246 −1513 −2127 −2222 −955−1242 35 −1675 −1197 −1424 −2426 −659 3303 −1507 −1331 1211 −2220 −186832 — −149 −500 233 43 −381 399 106 −626 210 −466 −720 275 394 45 96 359117 −369 −294 −249 — −16 −7108 −8150 −894 −1115 −701 −1378 * *  23(A)1948 −1167 −891 1114 −1539 −1605 −710 −688 −551 −1278 −608 −703 −1861−451 −928 −724 −609 1295 −1870 −1386 33 — −149 −500 233 43 −381 399 106−626 210 −466 −720 275 394 45 96 359 117 −369 −294 −249 — −16 −7108−8150 −894 −1115 −701 −1378 * *  24(A) 2275 −1339 −993 −558 −2142 −1451−682 −1733 1352 −1909 −1113 −663 −1785 −334 −564 −587 928 −1336 −2220−1732 34 — −149 −500 233 43 −381 399 106 −626 210 −466 −720 275 394 4596 359 117 −369 −294 −249 — −16 −7108 −8150 −894 −1115 −701 −1378 * * 25(N) −1216 −1775 −1072 −1034 −1473 −1967 −1153 −1429 −1009 767 −11653461 −2339 −1043 −1259 −1335 −1316 −1331 −1982 −1273 35 — −149 −500 23343 −381 399 106 −626 210 −466 −720 275 394 45 96 359 117 −369 −294 −249— −16 −7108 −8150 −894 −1115 −701 −1378 * *  26(Y) −2131 −1808 −3471−3249 538 −3299 −814 1516 −2817 −864 −742 −2495 −3305 −2356 −2649 −2520−2091 −784 −205 4093 36 — −149 −500 233 43 −381 399 106 −626 210 −466−720 275 394 45 96 359 117 −369 −294 −249 — −16 −7108 −8150 −894 −1115−701 −1378 * *  27(L) −2321 −1872 −4652 −4075 −539 −4266 −3092 2178−3803 2345 2067 −3915 −3747 −2978 −3487 −3494 −2215 −175 −2130 −2157 37— −149 −500 233 43 −381 399 106 −626 210 −466 −720 275 394 45 96 359 117−369 −294 −249 — −16 −7108 −8150 −894 −1115 −701 −1378 * *  28(S) −482−1136 −1858 −1915 −3072 −1315 −1996 −2905 −2045 −3106 −2272 −1475 1651−1840 −2205 3016 −873 −2011 −3242 −2908 38 — −149 −500 233 43 −381 399106 −626 210 −466 −720 275 394 45 96 359 117 −369 −294 −249 — −16 −7108−8150 −894 −1115 −701 −1378 * *  29(V) 845 −1090 −3817 −3373 −1522 −3377−2794 2147 −3161 −649 −421 −3056 −3362 −2955 −3177 −2598 −1419 2690−2606 −2197 39 — −149 −500 233 43 −381 399 106 −626 210 −466 −720 275394 45 96 359 117 −369 −294 −249 — −16 −7108 −8150 −894 −1115 −701−1378 * *  30(G) −1283 −2067 −837 −965 −3177 3042 −1462 −3119 −1171−3141 −2429 −1111 −2331 2005 −1448 −1320 −1499 −2538 −3099 −2665 40 —−149 −500 233 43 −381 399 106 −626 210 −466 −720 275 394 45 96 359 117−369 −294 −249 — −16 −7108 −8150 −894 −1115 −701 −1378 * *  31(Q) −974−2142 −780 −270 −2589 −1791 −328 −2217 1581 −2142 −1329 −487 −1903 3083262 −876 671 −1860 −2250 −1764 41 — −149 −500 233 43 −381 399 106 −626210 −466 −720 275 394 45 96 359 117 −369 −294 −249 — −16 −7108 −8150−894 −1115 −701 −1378 * *  32(L) −1375 −1127 −3503 −2949 −697 −3071−2054 1887 −2629 2035 342 −2656 −2990 −2251 −2534 −2214 1157 428 −1759−1511 42 — −149 −500 233 43 −381 399 106 −626 210 −466 −720 275 394 4596 359 117 −369 −294 −249 — −16 −7108 −8150 −894 −1115 −701 −1378 * * 33(Y) −1937 −2273 −1926 −1563 −232 −2608 −650 −2164 1538 −2035 −1599−1501 −2740 −960 −541 −1929 −1851 −2048 −794 4044 43 — −149 −500 233 43−381 399 106 −626 210 −466 −720 275 394 45 96 359 117 −369 −294 −249 —−16 −7108 −8150 −894 −1115 −701 −1378 * *  34(L) −2871 −2457 −4231 −4103−1033 −3803 −3165 −541 −3734 3130 −31 −3935 −3797 −3286 −3484 −3713−2869 −1136 −2394 −2220 44 — −149 −500 233 43 −381 399 106 −626 210 −466−720 275 394 45 96 359 117 −369 −294 −249 — −16 −7108 −8150 −894 −1115−701 −1378 * *  35(K) −565 −1769 −542 1150 −2042 −1544 −133 −1707 1529−200 1362 −220 −1622 291 1492 −490 −487 −1367 −1948 −1377 45 — −149 −500233 43 −381 399 106 −626 210 −466 −720 275 394 45 96 359 117 −369 −294−249 — −16 −7108 −8150 −894 −1115 −701 −1378 * *  36(D) −733 −2199 2095230 −2550 256 −327 −2314 1307 −2269 −1390 −100 −1681 97 −574 1114 −708−1861 −2454 −1735 46 — −149 −500 233 43 −381 399 106 −626 210 −466 −720275 394 45 96 359 117 −369 −294 −249 — −16 −7108 −8150 −894 −1115 −701−1378 * *  37(N) −1190 −2662 1381 127 −3153 −1520 −768 −2990 −757 −2945−2156 3138 −1961 −405 −1416 1061 −1253 −2479 −3137 −2313 47 — −149 −500233 43 −381 399 106 −626 210 −466 −720 275 394 45 96 359 117 −369 −294−249 — −16 −7108 −8150 −894 −1115 −701 −1378 * *  38(P) −1777 −2801 1868−561 −3633 −1918 −1524 −3634 −1721 −3620 −2978 −881 3543 −1257 −2350−1648 −1944 −3091 −3510 −2972 48 — −149 −500 233 43 −381 399 106 −626210 −466 −720 275 394 45 96 359 117 −369 −294 −249 — −16 −7108 −8150−894 −1115 −701 −1378 * *  39(C) −1617 2940 −3806 −3389 −788 −2963 −2369−4 −2967 2637 197 −2927 −3094 −2569 −2799 −2284 −1672 −278 −1950 −168049 — −149 −500 233 43 −381 399 106 −626 210 −466 −720 275 394 45 96 359117 −369 −294 −249 — −16 −7108 −8150 −894 −1115 −701 −1378 * *  40(M)−1138 −1232 1092 −1546 −625 −2468 −1290 −56 −1453 1974 2682 −1610 −2481−1228 −1655 −1558 −1079 −283 −1540 −1223 50 — −149 −500 233 43 −381 399106 −626 210 −466 −720 275 394 45 96 359 117 −369 −294 −249 — −16 −7108−8150 −894 −1115 −701 −1378 * *  41(H) −30 439 11 363 −394 −739 699 −414463 −757 501 286 −577 639 165 −23 111 −312 697 −25 51 — −149 −500 233 43−381 399 106 −626 210 −466 −720 275 394 45 96 359 117 −369 −294 −249 —−16 −7108 −8150 −894 −1115 −701 −1378 * *  42(K) 784 −2190 −977 −302−2645 −1847 −256 −2259 2452 −2136 −1309 −504 −1900 1339 1312 −874 −863−1897 −2202 −1742 52 — −149 −500 233 43 −381 399 106 −626 210 −466 −720275 394 45 96 359 117 −369 −294 −249 — −16 −7108 −8150 −894 −1115 −701−1378 * *  43(E) −648 −1915 −516 1778 −2222 −1578 −162 −1899 439 163−1023 −238 −1667 1297 1557 −552 −568 −1536 −2057 −1482 53 — −149 −500233 43 −381 399 106 −626 210 −466 −720 275 394 45 96 359 117 −369 −294−249 — −16 −7108 −8150 −894 −1115 −701 −1378 * *  44(P) −1091 −2157 −710−354 −2472 −1828 2409 −2236 1296 −2195 −1418 −568 2737 −72 88 −1007−1021 −1903 −2268 −1751 54 — −149 −500 233 43 −381 399 106 −626 210 −466−720 275 394 45 96 359 117 −369 −294 −249 — −16 −7108 −8150 −894 −1115−701 −1378 * *  45(L) −1149 −1110 −2516 −1945 1939 −2543 −1114 −128 10511953 309 −1805 −2527 −1346 −1480 −1629 −1078 −306 −1080 −509 55 — −149−500 233 43 −381 399 106 −626 210 −466 −720 275 394 45 96 359 117 −369−294 −249 — −16 −7108 −8150 −894 −1115 −701 −1378 * *  46(T) −695 −1464−884 −358 −1467 −1703 −361 −1272 1547 −1430 −690 −543 −1822 −57 −149−739 2166 −1045 −1654 1676 56 — −149 −500 233 43 −381 399 106 −626 210−466 −720 275 394 45 96 359 117 −369 −294 −249 — −16 −7108 −8150 −894−1115 −701 −1378 * *  47(R) 1626 −2138 −1332 −620 −2693 −1985 −403 −22491356 −2167 −1392 −747 −2067 11 2526 −1100 −1051 −1929 −2243 −1870 57 —−149 −500 233 43 −381 399 106 −626 210 −466 −720 275 394 45 96 359 117−369 −294 −249 — −16 −7108 −8150 −894 −1115 −701 −1378 * *  48(E) 378−1941 703 1824 −2252 −1386 −100 −2000 289 −1956 −1046 −24 −1516 349 1172476 −427 −1561 −2134 −1447 58 — −149 −500 233 43 −381 399 106 −626 210−466 −720 275 394 45 96 359 117 −369 −294 −249 — −16 −7108 −8150 −894−1115 −701 −1378 * *  49(D) 923 −2559 2894 160 −2929 −1519 −635 −2712−524 −2688 −1882 −189 −1895 1449 −1131 −904 −1111 −2258 −2898 −2120 59 —−149 −500 233 43 −381 399 106 −626 210 −466 −720 275 394 45 96 359 117−369 −294 −249 — −16 −7108 −8150 −894 −1115 −701 −1378 * *  50(V) 1091−1040 −3230 −3029 −1839 −2191 −2521 453 −2807 −1107 −816 −2387 −2674−2598 −2801 −1506 −1141 3085 −2726 −2349 60 — −149 −500 233 43 −381 399106 −626 210 −466 −720 275 394 45 96 359 117 −369 −294 −249 — −16 −7108−8150 −894 −1115 −701 −1378 * *  51(K) 1016 −1925 −1252 −838 −2825 −1834−758 −2369 3094 −2408 −1667 −917 −2126 −380 −14 −1094 −1125 −1973 −2524−2145 61 — −149 −500 233 43 −381 399 106 −626 210 −466 −720 275 394 4596 359 117 −369 −294 −249 — −16 −7108 −8150 −894 −1115 −701 −1378 * * 52(H) −477 −400 −2258 −1664 1050 −1948 2313 1043 −1367 −239 404 −1388365 −1083 −1355 −1008 −417 915 −715 1744 62 — −149 −500 233 43 −381 399106 −626 210 −466 −720 275 394 45 96 359 117 −369 −294 −249 — −16 −7108−8150 −894 −1115 −701 −1378 * *  53(H) −1023 −1918 −1234 −509 −2208−1943 3152 947 1315 −1817 −1055 −662 −1981 64 1825 −993 −895 −1542 −1997−1584 63 — −149 −500 233 43 −381 399 106 −626 210 −466 −720 275 394 4596 359 117 −369 −294 −249 — −16 −7108 −8150 −894 −1115 −701 −1378 * * 54(P) 1113 −913 −1858 −1496 −1358 −1604 −1238 −756 −1296 958 −503 −13062592 −1174 −1479 −817 −686 −602 −1858 −1474 64 — −149 −500 233 43 −381399 106 −626 210 −466 −720 275 394 45 96 359 117 −369 −294 −249 — −16−7108 −8150 −894 −1115 −701 −1378 * *  55(I) 846 −1093 −3818 −3374 −1512−3374 −2792 2798 −3161 −633 −411 −3056 −3360 −2951 −3174 −2596 −14222077 −2600 −2195 65 — −149 −500 233 43 −381 399 106 −626 210 −466 −720275 394 45 96 359 117 −369 −294 −249 — −16 −7108 −8150 −894 −1115 −701−1378 * *  56(G) −2594 −2690 −3304 −3623 −4328 3747 −3462 −4761 −3953−4671 −4212 −3320 −3352 −3748 −3779 −2839 −2981 −4004 −3668 −4222 66 —−149 −500 233 43 −381 399 106 −626 210 −466 −720 275 394 45 96 359 117−369 −294 −249 — −16 −7108 −8150 −894 −1115 −701 −1378 * *  57(H) −3205−3079 −2723 −2890 −2110 −3046 5295 −4135 −2617 −3813 −3561 −2886 −3482−2833 −2620 −3291 −3356 −3895 −2397 −1681 67 — −149 −500 233 43 −381 399106 −626 210 −466 −720 275 394 45 96 359 117 −369 −294 −249 — −16 −7108−8150 −894 −1115 −701 −1378 * *  58(W) −4114 −3274 −4214 −4453 −1722−3496 −2681 −4109 −4149 −3619 −3615 −4044 −3885 −4032 −3816 −4355 −4248−4133 6191 −1329 68 — −149 −500 233 43 −381 399 106 −626 210 −466 −720275 394 45 96 359 117 −369 −294 −249 — −16 −7108 −8150 −894 −1115 −701−1378 * *  59(G) −2594 −2690 −3304 −3623 −4328 3747 −3462 −4761 −3953−4671 −4212 −3320 −3352 −3748 −3779 −2839 −2981 −4004 −3668 −4222 69 —−149 −500 233 43 −381 399 106 −626 210 −466 −720 275 394 45 96 359 117−369 −294 −249 — −16 −7108 −8150 −894 −1115 −701 −1378 * *  60(T) −1213−1674 −2755 −2906 −3163 −1922 −2659 −2698 −2788 −3105 −2612 −2311 −2600−2708 −2753 −1463 3819 −2197 −3286 −3156 70 — −149 −500 233 43 −381 399106 −626 210 −466 −720 275 394 45 96 359 117 −369 −294 −249 — −16 −7108−8150 −894 −1115 −701 −1378 * *  61(C) −859 2735 −3125 −2633 −1043 −2353−1765 2619 −2314 −561 −137 −2173 −2560 −2046 −2258 −1540 1442 680 −1746−1384 71 — −149 −500 233 43 −381 399 106 −626 210 −466 −720 275 394 4596 359 117 −369 −294 −249 — −16 −7108 −8150 −894 −1115 −701 −1378 * * 62(P) 1490 −891 −2212 −1956 −2077 −1371 −1689 −1274 −1796 −1861 −1203−1479 2954 −1611 −1936 −653 −684 816 −2478 −2131 72 — −149 −500 233 43−381 399 106 −626 210 −466 −720 275 394 45 96 359 117 −369 −294 −249 —−16 −7108 −8150 −894 −1115 −701 −1378 * *  63(G) −382 −1055 −1768 −1819−3131 2891 −1951 −2904 −2042 −3099 −2224 −1384 1043 −1771 −2236 1022−775 −1958 −3301 −2980 73 — −149 −500 233 43 −381 399 106 −626 210 −466−720 275 394 45 96 359 117 −369 −294 −249 — −16 −7108 −8150 −894 −1115−701 −1378 * *  64(Q) −1532 −1831 −1845 −1487 −1032 −2520 −1248 −707−794 1863 −184 −1573 −2625 2991 −924 −1768 −1488 −990 −1859 −1397 74 —−149 −500 233 43 −381 399 106 −626 210 −466 −720 275 394 45 96 359 117−369 −294 −249 — −16 −7108 −8150 −894 −1115 −701 −1378 * *  65(N) −1040−1491 −1193 −1126 −1577 −1932 −1248 1438 −1138 −1433 −1011 3384 −2307−1120 −1396 −1256 −1150 −579 −2101 −1473 75 — −149 −500 233 43 −381 399106 −626 210 −466 −720 275 394 45 96 359 117 −369 −294 −249 — −16 −7108−8150 −894 −1115 −701 −1378 * *  66(F) −2629 −2152 −4261 −4009 3717−3972 −1470 −438 −3655 1364 94 −3253 −3712 −2829 −3311 −3250 −2543 −971−709 261 76 — −149 −500 233 43 −381 399 106 −626 210 −466 −720 275 39445 96 359 117 −369 −294 −249 — −16 −7108 −8150 −894 −1115 −701 −1378 * * 67(I) −1794 −1354 −4306 −3856 −1267 −3968 −3273 2808 −3666 1262 −89−3607 −3721 −3300 −3605 −3222 −1758 1880 −2695 −2428 77 — −149 −500 23343 −381 399 106 −626 210 −466 −720 275 394 45 96 359 117 −369 −294 −249— −16 −7108 −8150 −894 −1115 −701 −1378 * *  68(Y) −1692 −1412 −3458−3020 258 −3136 −1081 1186 −2630 646 −31 −2459 −3064 −2167 −2476 −2272−1624 −329 −544 3829 78 — −149 −500 233 43 −381 399 106 −626 210 −466−720 275 394 45 96 359 117 −369 −294 −249 — −16 −7108 −8150 −894 −1115−701 −1378 * *  69(A) 2378 −934 −2147 −1885 −2779 826 −1775 −2485 −1781−2703 −1842 −1381 −1860 −1577 −1989 1353 1040 −1689 −2983 −2654 79 —−149 −500 233 43 −381 399 106 −626 210 −466 −720 275 394 45 96 359 117−369 −294 −249 — −16 −7108 −8150 −894 −1115 −701 −1378 * *  70(H) −3205−3079 −2723 −2890 −2110 −3046 5295 −4135 −2617 −3813 −3561 −2886 −3482−2833 −2620 −3291 −3356 −3895 −2397 −1681 80 — −149 −500 233 43 −381 399106 −626 210 −466 −720 275 394 45 96 359 117 −369 −294 −249 — −16 −7108−8150 −894 −1115 −701 −1378 * *  71(L) −2379 −1915 −4669 −4151 −621−4360 −3248 1934 −3862 2632 553 −4017 −3845 −3099 −3585 −3641 −2289 −24−2250 −2225 81 — −149 −500 233 43 −381 399 106 −626 210 −466 −720 275394 45 96 359 117 −369 −294 −249 — −16 −7108 −8150 −894 −1115 −701−1378 * *  72(N) −2171 −2655 −1458 −1748 −3334 −2364 −2267 −3943 −2365−3936 −3437 4205 −2932 −2205 −2608 −2224 −2439 −3392 −3253 −2909 82 —−149 −500 233 43 −381 399 106 −626 210 −466 −720 275 394 45 96 359 117−369 −294 −249 — −16 −7108 −8150 −894 −1115 −701 −1378 * *  73(R) −1929−2343 −2336 −1600 −825 −2607 −677 −2317 45 −2153 −1653 −1506 −2681 −6793382 −1922 −1792 −2176 −1232 2267 83 — −149 −500 233 43 −381 399 106−626 210 −466 −720 275 394 45 96 359 117 −369 −294 −249 — −16 −7108−8150 −894 −1115 −701 −1378 * *  74(V) 503 −701 −3099 −2506 1199 −2516−1425 486 −2168 1370 379 −2113 −2515 −1800 −2039 −1621 −848 2021 −1247−916 84 — −149 −500 233 43 −381 399 106 −626 210 −466 −720 275 394 45 96359 117 −369 −294 −249 — −16 −7108 −8150 −894 −1115 −701 −1378 * * 75(I) −2091 −1746 −3971 −3840 −1676 −3532 −3289 3684 −3581 −659 −693−3562 −3674 −3445 −3521 −3194 −2146 449 −2877 −2493 85 — −149 −500 23343 −381 399 106 −626 210 −466 −720 275 394 45 96 359 117 −369 −294 −249— −16 −7108 −8150 −894 −1115 −701 −1378 * *  76(K) 1051 −1939 −439 −69−2445 −1557 −349 −2132 2202 −2116 −1268 1786 −1753 70 −141 −646 −704−1719 −2284 −1701 86 — −149 −500 233 43 −381 399 106 −626 210 −466 −720275 394 45 96 359 117 −369 −294 −249 — −16 −7108 −8150 −894 −1115 −701−1378 * *  77(K) −1384 −2800 1892 −69 −3174 −1733 −742 −2966 2973 −2873−2105 −400 −2087 −365 −775 −1179 −1372 −2535 −2949 −2288 87 — −149 −500233 43 −381 399 106 −626 210 −466 −720 275 394 45 96 359 117 −369 −294−249 — −16 −7108 −8150 −894 −1115 −701 −1378 * *  78(Y) −2118 −2084−2592 −2218 1983 −3049 2937 −1851 −1966 −1662 −1339 −1862 −3049 1795−2085 −2125 −2036 −1809 122 3287 88 — −149 −500 233 43 −381 399 106 −626210 −466 −720 275 394 45 96 359 117 −369 −294 −249 — −16 −7108 −8150−894 −1115 −701 −1378 * *  79(N) −1107 −2701 1326 223 −2992 1724 −586−2799 −472 −2733 −1910 2292 −1876 1179 −1098 −894 −1109 −2331 −2923−2116 89 — −149 −500 233 43 −381 399 106 −626 210 −466 −720 275 394 4596 359 117 −369 −294 −249 — −16 −7108 −8150 −894 −1115 −701 −1378 * * 80(L) −1690 −1806 −2247 −1903 −837 −2782 −1536 −464 −1204 2489 81 −1939−2835 1986 −1289 −2052 −1642 −850 −1841 −1451 90 — −149 −500 233 43 −381399 106 −626 210 −466 −720 275 394 45 96 359 117 −369 −294 −249 — −16−7108 −8150 −894 −1115 −701 −1378 * *  81(D) −1292 −2956 2598 202 −3213−1558 −693 −3045 851 −2958 −2170 2502 −1967 −318 −1262 −1043 −1304 −2569−3134 −2291 91 — −149 −500 233 43 −381 399 106 −626 210 −466 −720 275394 45 96 359 117 −369 −294 −249 — −16 −7108 −8150 −894 −1115 −701−1378 * *  82(M) −866 −1094 −2548 −2220 −1176 −1993 −1696 −374 −1810−470 4232 −1867 −2385 −1729 −1855 −1260 1587 −400 −1960 −1618 92 — −149−500 233 43 −381 399 106 −626 210 −466 −720 275 394 45 96 359 117 −369−294 −249 — −16 −7108 −8150 −894 −1115 −701 −1378 * *  83(F) −1725 −1400−3934 −3394 2962 −3436 −2055 325 −3076 1369 437 −3005 −3243 −2505 −2863−2595 −1653 1644 −1488 −995 93 — −149 −500 233 43 −381 399 106 −626 210−466 −720 275 394 45 96 359 117 −369 −294 −249 — −16 −7108 −8150 −894−1115 −701 −1378 * *  84(Y) −2852 −2251 −3961 −3935 2281 −3735 −476 168−3538 −1379 −1299 −2630 −3641 −2627 −3134 −2925 −2756 −1840 233 4154 94— −149 −500 233 43 −381 399 106 −626 210 −466 −720 275 394 45 96 359 117−369 −294 −249 — −16 −7108 −8150 −894 −1115 −701 −1378 * *  85(I) −1759−1305 −4328 −3965 −1743 −4047 −3735 3086 −3833 −588 −522 −3726 −3872−3681 −3903 −3364 −1752 2354 −3250 −2813 95 — −149 −500 233 43 −381 399106 −626 210 −466 −720 275 394 45 96 359 117 −369 −294 −249 — −16 −7108−8150 −894 −1115 −701 −1378 * *  86(M) −700 −1108 −1144 2046 −1106 −1894−710 −177 −572 −648 2421 −857 −1997 −497 −908 −934 −657 1171 −1602 −115596 — −149 −500 233 43 −381 399 106 −626 210 −466 −720 275 394 45 96 359117 −369 −294 −249 — −16 −7108 −8150 −894 −1115 −701 −1378 * *  87(G)−2594 −2690 −3304 −3623 −4328 3747 −3462 −4761 −3953 −4671 −4212 −3320−3352 −3748 −3779 −2839 −2981 −4004 −3668 −4222 97 — −149 −500 233 43−381 399 106 −626 210 −466 −720 275 394 45 96 359 117 −369 −294 −249 —−16 −7108 −8150 −894 −1115 −701 −1378 * *  88(P) −526 −1169 −1848 −1957−3095 −1343 −2052 −2946 −2123 −3152 −2333 −1513 3407 −1917 −2261 1632−922 −2053 −3267 −2938 98 — −149 −500 233 43 −381 399 106 −626 210 −466−720 275 394 45 96 359 117 −369 −294 −249 — −16 −7108 −8150 −894 −1115−701 −1378 * *  89(G) −2594 −2690 −3304 −3623 −4328 3747 −3462 −4761−3953 −4671 −4212 −3320 −3352 −3748 −3779 −2839 −2981 −4004 −3668 −422299 — −149 −500 233 43 −381 399 106 −626 210 −466 −720 275 394 45 96 359117 −369 −294 −249 — −16 −7108 −8150 −894 −1115 −701 −1378 * *  90(H)−3205 −3079 −2723 −2890 −2110 −3046 5295 −4135 −2617 −3813 −3561 −2886−3482 −2833 −2620 −3291 −3356 −3895 −2397 −1681 100 — −149 −500 233 43−381 399 106 −626 210 −466 −720 275 394 45 96 359 117 −369 −294 −249 —−16 −7108 −8150 −894 −1115 −701 −1378 * *  91(G) −2594 −2690 −3304 −3623−4328 3747 −3462 −4761 −3953 −4671 −4212 −3320 −3352 −3748 −3779 −2839−2981 −4004 −3668 −4222 101 — −149 −500 233 43 −381 399 106 −626 210−466 −720 275 394 45 96 359 117 −369 −294 −249 — −16 −7108 −8150 −894−1115 −701 −1378 * *  92(H) −30 439 11 363 −394 −739 699 −414 463 −757501 286 −577 639 165 −23 111 −312 697 −25 102 — −149 −500 233 43 −381399 106 −626 210 −466 −720 275 394 45 96 359 117 −369 −294 −249 — −16−7108 −8150 −894 −1115 −701 −1378 * *  93(G) 1432 −1081 −2340 −2519−3309 3113 −2408 −3041 −2687 −3327 −2482 −1740 −2062 −2353 −2689 −702−903 −2058 −3476 −3301 103 — −149 −500 233 43 −381 399 106 −626 210 −466−720 275 394 45 96 359 117 −369 −294 −249 — −16 −7108 −8150 −894 −1115−701 −1378 * *  94(Q) −1326 −2187 −825 −789 −2878 −1884 −1131 −2784 −631−2752 −2063 −977 2646 3194 −881 −1313 −1428 −2357 −2787 −2310 104 — −149−500 233 43 −381 399 106 −626 210 −466 −720 275 394 45 96 359 117 −369−294 −249 — −16 −7108 −8150 −894 −1115 −701 −1378 * *  95(V) 1470 −815−2475 −2234 −1874 1135 −1780 −892 −2064 −1657 −1016 −1624 −2020 −1814−2121 −717 −687 2477 −2329 −1999 105 — −149 −500 233 43 −381 399 106−626 210 −466 −720 275 394 45 96 359 117 −369 −294 −249 — −16 −7108−8150 −894 −1115 −701 −1378 * *  96(M) −883 −899 −2454 −1951 −595 991−1285 −31 −1626 1077 3599 −1754 −2362 −1420 −1669 −1376 −878 −131 −1359−1024 106 — −149 −500 233 43 −381 399 106 −626 210 −466 −720 275 394 4596 359 117 −369 −294 −249 — −16 −7108 −8150 −894 −1115 −701 −1378 * * 97(V) −1205 −914 −3493 −2955 −1023 −3025 −2085 1649 −2672 917 −32 −2617−2982 −2375 −2606 −2169 1373 2267 −1903 −1552 107 — −149 −500 233 43−381 399 106 −626 210 −466 −720 275 394 45 96 359 117 −369 −294 −249 —−16 −7108 −8150 −894 −1115 −701 −1378 * *  98(S) 1719 −1145 −1296 −1130−2738 −1260 −1357 −2461 −1234 −2624 −1769 1171 −1844 −1070 1576 2383−686 −1744 −2874 −2423 108 — −149 −500 233 43 −381 399 106 −626 210 −466−720 275 394 45 96 359 117 −369 −294 −249 — −16 −7108 −8150 −894 −1115−701 −1378 * *  99(N) −809 −2086 −98 33 −2593 −1494 −488 −2361 −147−2346 −1503 2681 −1787 1970 −607 984 −825 −1908 −2521 −1851 109 — −149−500 233 43 −381 399 106 −626 210 −466 −720 275 394 45 96 359 117 −369−294 −249 — −16 −7108 −8150 −894 −1115 −701 −1378 * * 100(S) 878 −890−1818 −1458 −1679 −1418 −1269 −1166 −1293 665 −837 −1224 −1904 −1156−1509 2469 −610 −869 −2068 −1669 110 — −149 −500 233 43 −381 399 106−626 210 −466 −720 275 394 45 96 359 117 −369 −294 −249 — −16 −7108−8150 −894 −1115 −701 −1378 * * 101(Y −3588 −2709 −4120 −4323 1034 −3994−419 −2613 −3834 −2031 −2055 −2741 −3905 −2826 −3349 −3280 −3472 −27363673 4312 111 — −149 −500 233 43 −381 399 106 −626 210 −466 −720 275 39445 96 359 117 −369 −294 −249 — −16 −7108 −8150 −894 −1115 −701 −1378 * *102(L) −2496 −2027 −4721 −4202 −560 −4432 −3262 1210 −3887 2852 611−4095 −3876 −3086 −3587 −3729 −2397 −232 −2211 −2201 112 — −149 −500 23343 −381 399 106 −626 210 −466 −720 275 394 45 96 359 117 −369 −294 −249— −16 −7108 −8150 −894 −1115 −701 −1378 * * 103(D −1791 −3663 3414 1659−3853 −1647 −1043 −3807 −1343 −3679 −3054 −251 −2201 −725 −2227 −1438−1872 −3282 −3836 −2831 113 — −149 −500 233 43 −381 399 106 −626 210−466 −720 275 394 45 96 359 117 −369 −294 −249 — −16 −7108 −8150 −894−1115 −701 −1378 * * 104(G −2594 −2690 −3304 −3623 −4328 3747 −3462−4761 −3953 −4671 −4212 −3320 −3352 −3748 −3779 −2839 −2981 −4004 −3668−4222 114 — −149 −500 233 43 −381 399 106 −626 210 −466 −720 275 394 4596 359 117 −369 −294 −249 — −16 −7108 −8150 −894 −1115 −701 −1378 * *105(S) −342 −976 −2177 −2128 −2921 −1229 −2008 −2606 −2073 −2888 −2058−1512 −1936 −1871 −2189 2669 2327 −1779 −3151 −2842 115 — −149 −500 23343 −381 399 106 −626 210 −466 −720 275 394 45 96 359 117 −369 −294 −249— −16 −7108 −8150 −894 −1115 −701 −1378 * * 106(Y −2652 −2206 −3673−3556 726 −3580 −692 −1359 −3066 982 −936 −2620 −3538 −2500 −2832 −2837−2587 −1595 −24 4185 116 — −149 −500 233 43 −381 399 106 −626 210 −466−720 275 394 45 96 359 117 −369 −294 −249 — −16 −7108 −8150 −894 −1115−701 −1378 * * 107(T) −502 −1110 −2201 −2282 −3095 1340 −2204 −2779−2341 −3075 −2268 −1660 −2066 −2111 −2412 −729 3346 −1945 −3276 −3043117 — −149 −500 233 43 −381 399 106 −626 210 −466 −720 275 394 45 96 359117 −369 −294 −249 — −16 −7108 −8150 −894 −1115 −701 −1378 * * 108(E)−1163 −2811 1893 2460 −3072 −1535 −594 −2884 1337 −2797 −1978 −140 −1898−203 −1072 −933 −1159 −2412 −2972 −2157 118 — −149 −500 233 43 −381 399106 −626 210 −466 −720 275 394 45 96 359 117 −369 −294 −249 — −16 −7108−8150 −894 −1115 −701 −1378 * * 109(I) 561 −338 −2506 −1896 1485 −1980−829 1917 −1557 −155 470 −1524 −2033 −1236 −1465 −1055 777 309 −776 1058119 — −149 −500 233 43 −381 399 106 −626 210 −466 −720 275 394 45 96 359117 −369 −294 −249 — −16 −7108 −8150 −894 −1115 −701 −1378 * * 110(Y−3611 −2705 −4166 −4409 2531 −4042 −397 −2533 −3989 −1938 −1983 −2747−3929 −2851 −3444 −3294 −3491 −2684 345 4289 120 — −149 −500 233 43 −381399 106 −626 210 −466 −720 275 394 45 96 359 117 −369 −294 −249 — −16−7108 −8150 −894 −1115 −701 −1378 * * 111(P) −2931 −2878 −3420 −3706−4181 −2925 −3468 −4621 −3859 −4490 −4165 −3491 4225 −3781 −3695 −3182−3279 −4087 −3594 −4064 121 — −149 −500 233 43 −381 399 106 −626 210−466 −720 275 394 45 96 359 117 −369 −294 −249 — −16 −7108 −8150 −894−1115 −701 −1378 * * 112(E) −785 −2281 −2 1960 −2596 −1496 −297 −2348660 −2275 −1399 1934 −1705 1721 −381 −626 −738 −1906 −2432 −1737 122 —−149 −500 233 43 −381 399 106 −626 210 −466 −720 275 394 45 96 359 117−369 −294 −249 — −16 −7108 −8150 −894 −1115 −701 −1378 * * 113(I) −1722−1438 −3424 −3080 131 −3150 −1169 2917 −2681 −503 −344 −2513 −3144 −2305−2554 −2347 −1683 −39 −645 2880 123 — −149 −500 233 43 −381 399 106 −626210 −466 −720 275 394 45 96 359 117 −369 −294 −249 — −16 −7108 −8150−894 −1115 −701 −1378 * * 114(T) −1213 −1674 −2755 −2906 −3163 −1922−2659 −2698 −2788 −3105 −2612 −2311 −2600 −2708 −2753 −1463 3819 −2197−3286 −3156 124 — −149 −500 233 43 −381 399 106 −626 210 −466 −720 275394 45 96 359 117 −369 −294 −249 — −16 −7108 −8150 −894 −1115 −701−1378 * * 115(Q −1609 −2594 −1354 −790 −3182 −2213 −519 −2737 2527 −2514−1787 −903 −2297 3031 525 −1483 −1437 −2432 −2460 −2150 125 — −149 −500233 43 −381 399 106 −626 210 −466 −720 275 394 45 96 359 117 −369 −294−249 — −16 −7108 −8150 −894 −1115 −701 −1378 * * 116(D −2784 −3432 4016−1200 −4140 −2466 −2197 −4505 −2621 −4365 −3956 −1551 −3014 −2039 −3232−2593 −2938 −4046 −3710 −3552 126 — −149 −500 233 43 −381 399 106 −626210 −466 −720 275 394 45 96 359 117 −369 −294 −249 — −16 −7108 −8150−894 −1115 −701 −1378 * * 117(E) −495 −1766 −320 2020 −2044 −1449 −133−1708 1298 −1759 −898 −124 −1562 295 −155 −410 632 108 −1998 −1374 127 —−149 −500 233 43 −381 399 106 −626 210 −466 −720 275 394 45 96 359 117−369 −294 −249 — −16 −7108 −8150 −894 −1115 −701 −1378 * * 118(E) 1485−2051 −202 1709 −2406 −1511 −270 −2112 1557 −2089 −1228 −183 −1688 156−234 −586 −657 −1706 −2272 −1633 128 — −149 −500 233 43 −381 399 106−626 210 −466 −720 275 394 45 96 359 117 −369 −294 −249 — −16 −7108−8150 −894 −1115 −701 −1378 * * 119(G −2594 −2690 −3304 −3623 −4328 3747−3462 −4761 −3953 −4671 −4212 −3320 −3352 −3748 −3779 −2839 −2981 −4004−3668 −4222 129 — −149 −500 233 43 −381 399 106 −626 210 −466 −720 275394 45 96 359 117 −369 −294 −249 — −16 −7108 −8150 −894 −1115 −701−1378 * * 120(M −2568 −2113 −4714 −4154 −462 −4418 −3155 99 −3799 24693538 −4062 −3833 −2972 −3479 −3691 −2450 −587 −2108 −2139 130 — −149−500 233 43 −381 399 106 −626 210 −466 −720 275 394 45 96 359 117 −369−294 −249 — −16 −7108 −8150 −894 −1115 −701 −1378 * * 121(Q 447 −1907−448 −115 −2176 −1605 2296 −1980 143 −2000 −1194 −367 −1799 3046 −194−715 −752 −1626 −2150 −1543 131 — −149 −500 233 43 −381 399 106 −626 210−466 −720 275 394 45 96 359 117 −369 −294 −249 — −16 −7108 −8150 −894−1115 −701 −1378 * * 122(K −1448 −2495 −1440 −709 −3095 −2161 −406 −26162874 −2399 −1636 1544 −2197 22 1483 −1326 −1270 −2295 −2364 −2043 132 —−149 −500 233 43 −381 399 106 −626 210 −466 −720 275 394 45 96 359 117−369 −294 −249 — −16 −7108 −8150 −894 −1115 −701 −1378 * * 123(L) −2430−1987 −4659 −4071 2109 −4260 −2828 67 −3779 2463 2382 −3869 −3717 −2880−3418 −3473 −2306 −623 −1874 −1724 133 — −149 −500 233 43 −381 399 106−626 210 −466 −720 275 394 45 96 359 117 −369 −294 −249 — −16 −7108−8150 −894 −1115 −701 −1378 * * 124(F) −2144 −1762 −4034 −3706 3638−3656 −1587 1655 −3381 102 23 −3073 −3507 −2734 −3134 −2896 −2093 −241−906 16 134 — −149 −500 233 43 −381 399 106 −626 210 −466 −720 275 39445 96 359 117 −369 −294 −249 — −16 −7108 −8150 −894 −1115 −701 −1378 * *125(K −1297 −2351 −1405 −643 −2938 −2076 −377 −2482 2603 −2306 −1527−768 −2120 51 1973 899 −1147 −2149 −2307 −1957 135 — −149 −500 233 43−381 399 106 −626 210 −466 −720 275 394 45 96 359 117 −369 −294 −249 —−16 −7108 −8150 −894 −1115 −701 −1378 * * 126(Q −753 −1991 −692 −91−2345 −1670 1700 −2009 519 −1957 −1111 −334 −1745 2315 1728 −656 1061−1645 −2095 −1558 136 — −149 −500 233 43 −381 399 106 −626 210 −466 −720275 394 45 96 359 117 −369 −294 −249 — −16 −7108 −8150 −894 −1115 −701−1378 * * 127(F) −3342 −2776 −4026 −4232 4354 −3545 −1431 −2315 −4038−1801 −1900 −3299 −3780 −3350 −3645 −3490 −3420 −2566 −739 349 137 —−149 −500 233 43 −381 399 106 −626 210 −466 −720 275 394 45 96 359 117−369 −294 −249 — −16 −7108 −8150 −894 −1115 −701 −1378 * * 128(S) −897−1462 −2333 −2543 −3185 −1640 −2474 −3294 −2686 −3497 −2780 −1973 −2360−2483 −2703 3465 −1316 −2413 −3310 −3025 138 — −149 −500 233 43 −381 399106 −626 210 −466 −720 275 394 45 96 359 117 −369 −294 −249 — −16 −7108−8150 −894 −1115 −701 −1378 * * 129(F) −1908 −1643 −3261 −2963 3263−3050 −509 −1219 −2636 −1197 −851 −2199 −3071 −2085 −2476 −2189 1297−1211 77 2811 139 — −149 −500 233 43 −381 399 106 −626 210 −466 −720 275394 45 96 359 117 −369 −294 −249 — −16 −7108 −8150 −894 −1115 −701−1378 * * 130(P) −540 −1180 −1850 −1974 −3103 −1352 −2072 −2962 −2149−3170 −2355 −1527 3509 −1943 −2279 1382 −938 −2068 −3276 −2949 140 —−149 −500 233 43 −381 399 106 −626 210 −466 −720 275 394 45 96 359 117−369 −294 −249 — −16 −7108 −8150 −894 −1115 −701 −1378 * * 131(G 1432−1081 −2340 −2519 −3309 3113 −2408 −3041 −2687 −3327 −2482 −1740 −2062−2353 −2689 −702 −903 −2058 −3476 −3301 141 — −149 −500 233 43 −381 399106 −626 210 −466 −720 275 394 45 96 359 117 −369 −294 −249 — −16 −7108−8150 −894 −1115 −701 −1378 * * 132(G −2594 −2690 −3304 −3623 −4328 3747−3462 −4761 −3953 −4671 −4212 −3320 −3352 −3748 −3779 −2839 −2981 −4004−3668 −4222 142 — −149 −500 233 43 −381 399 106 −626 210 −466 −720 275394 45 96 359 117 −369 −294 −249 — −16 −7108 −8150 −894 −1115 −701−1378 * * 133(V −1322 −992 −3697 −3181 −1158 −3230 −2353 2069 −2914 914−126 −2840 −3160 −2624 −2849 −2396 641 2352 −2122 −1765 143 — −149 −500233 43 −381 399 106 −626 210 −466 −720 275 394 45 96 359 117 −369 −294−249 — −16 −7108 −8150 −894 −1115 −701 −1378 * * 134(P) 2498 −1088 −2250−2290 −3023 −1338 −2177 −2668 −2306 −2970 −2190 −1656 2760 −2080 −2382−710 −882 −1878 −3231 −2984 144 — −149 −500 233 43 −381 399 106 −626 210−466 −720 275 394 45 96 359 117 −369 −294 −249 — −16 −7108 −8150 −894−1115 −701 −1378 * * 135(S) −897 −1462 −2333 −2543 −3185 −1640 −2474−3294 −2686 −3497 −2780 −1973 −2360 −2483 −2703 3465 −1316 −2413 −3310−3025 145 — −149 −500 233 43 −381 399 106 −626 210 −466 −720 275 394 4596 359 117 −369 −294 −249 — −16 −7108 −8150 −894 −1115 −701 −1378 * *136(H −3205 −3079 −2723 −2890 −2110 −3046 5295 −4135 −2617 −3813 −3561−2886 −3482 −2833 −2620 −3291 −3356 −3895 −2397 −1681 146 — −149 −500233 43 −381 399 106 −626 210 −466 −720 275 394 45 96 359 117 −369 −294−249 — −16 −7108 −8150 −894 −1115 −701 −1378 * * 137(A 1947 −745 −2823−2285 1846 −2348 −1328 1572 −1988 −154 207 −1942 −2439 −1677 −1944 −1473−836 359 −1231 −781 147 — −149 −500 233 43 −381 399 106 −626 210 −466−720 275 394 45 96 359 117 −369 −294 −249 — −16 −7108 −8150 −894 −1115−701 −1378 * * 138(A 2029 −2389 1954 92 −2936 −1492 −703 −2716 −623−2715 −1906 1712 −1898 −331 −1237 −881 −1089 −2229 −2931 −2168 148 —−149 −500 233 43 −381 399 106 −626 210 −466 −720 275 394 45 96 359 117−369 −294 −249 — −16 −7108 −8150 −894 −1115 −701 −1378 * * 139(P) 1935−1116 −2232 −2301 −3058 −1358 −2206 −2705 −2336 −3009 −2238 −1674 3272−2114 −2406 −739 −914 −1913 −3260 −3019 149 — −149 −500 233 43 −381 399106 −626 210 −466 −720 275 394 45 96 359 117 −369 −294 −249 — −16 −7108−8150 −894 −1115 −701 −1378 * * 140(E) −1349 −2706 −162 2827 −3109 −1785−624 −2820 1799 −2704 −1931 −437 −2073 −230 −334 −1160 −1298 −2421 −2774−2189 150 — −149 −500 233 43 −381 399 106 −626 210 −466 −720 275 394 4596 359 117 −369 −294 −249 — −16 −7108 −8150 −894 −1115 −701 −1378 * *141(T) −645 −1000 −2671 −2474 −1925 −1699 −2057 −385 −2200 −1416 −1020−1885 −2274 −2057 −2247 −1011 3256 1160 −2570 −2205 151 — −149 −500 23343 −381 399 106 −626 210 −466 −720 275 394 45 96 359 117 −369 −294 −249— −16 −7108 −8150 −894 −1115 −701 −1378 * * 142(P) −2931 −2878 −3420−3706 −4181 −2925 −3468 −4621 −3859 −4490 −4165 −3491 4225 −3781 −3695−3182 −3279 −4087 −3594 −4064 152 — −149 −500 233 43 −381 399 106 −626210 −466 −720 275 394 45 96 359 117 −369 −294 −249 — −16 −7108 −8150−894 −1115 −701 −1378 * * 143(H −30 439 11 363 −394 −739 699 −414 463−757 501 286 −577 639 165 −23 111 −312 697 −25 153 — −149 −500 233 43−381 399 106 −626 210 −466 −720 275 394 45 96 359 117 −369 −294 −249 —−16 −7108 −8150 −894 −1115 −701 −1378 * * 144(G −2594 −2690 −3304 −3623−4328 3747 −3462 −4761 −3953 −4671 −4212 −3320 −3352 −3748 −3779 −2839−2981 −4004 −3668 −4222 154 — −149 −500 233 43 −381 399 106 −626 210−466 −720 275 394 45 96 359 117 −369 −294 −249 — −16 −7108 −8150 −894−1115 −701 −1378 * * 145(S) 1426 −949 −2380 −2419 −3107 −1201 −2226−2819 −2411 −3105 −2246 −1618 −1944 −2131 −2456 3026 −742 −1874 −3336−3080 155 — −149 −500 233 43 −381 399 106 −626 210 −466 −720 275 394 4596 359 117 −369 −294 −249 — −16 −7108 −8150 −894 −1115 −701 −1378 * *146(I) −2091 −1746 −3971 −3840 −1676 −3532 −3289 3684 −3581 −659 −693−3562 −3674 −3445 −3521 −3194 −2146 449 −2877 −2493 156 — −149 −500 23343 −381 399 106 −626 210 −466 −720 275 394 45 96 359 117 −369 −294 −249— −16 −7108 −8150 −894 −1115 −701 −1378 * * 147(H −3205 −3079 −2723−2890 −2110 −3046 5295 −4135 −2617 −3813 −3561 −2886 −3482 −2833 −2620−3291 −3356 −3895 −2397 −1681 157 — −149 −500 233 43 −381 399 106 −626210 −466 −720 275 394 45 96 359 117 −369 −294 −249 — −16 −7108 −8150−894 −1115 −701 −1378 * * 148(E) −2641 −3308 −896 3732 −3966 −2458 −2043−4105 −2128 −4016 −3555 −1531 −2959 −1842 −2560 −2479 −2750 −3722 −3563−3385 158 — −149 −500 233 43 −381 399 106 −626 210 −466 −720 275 394 4596 359 117 −369 −294 −249 — −16 −7108 −8150 −894 −1115 −701 −1378 * *149(G −2594 −2690 −3304 −3623 −4328 3747 −3462 −4761 −3953 −4671 −4212−3320 −3352 −3748 −3779 −2839 −2981 −4004 −3668 −4222 159 — −149 −500233 43 −381 399 106 −626 210 −466 −720 275 394 45 96 359 117 −369 −294−249 — −16 −7108 −8150 −894 −1115 −701 −1378 * * 150(G −2594 −2690 −3304−3623 −4328 3747 −3462 −4761 −3953 −4671 −4212 −3320 −3352 −3748 −3779−2839 −2981 −4004 −3668 −4222 160 — −149 −500 233 43 −381 399 106 −626210 −466 −720 275 394 45 96 359 117 −369 −294 −249 — −16 −7108 −8150−894 −1115 −701 −1378 * * 151(E) 669 −2323 −22 3133 −3044 −1600 −954−2706 −853 −2824 −2095 −473 −2059 −614 −1376 −1068 −1279 −2254 −3056−2376 161 — −149 −500 233 43 −381 399 106 −626 210 −466 −720 275 394 4596 359 117 −369 −294 −249 — −16 −7108 −8150 −894 −1115 −701 −1378 * *152(L) −2871 −2457 −4231 −4103 −1033 −3803 −3165 −541 −3734 3130 −31−3935 −3797 −3286 −3484 −3713 −2869 −1136 −2394 −2220 162 — −149 −500233 43 −381 399 106 −626 210 −466 −720 275 394 45 96 359 117 −369 −294−249 — −16 −7108 −8150 −894 −1115 −701 −1378 * * 153(G −2594 −2690 −3304−3623 −4328 3747 −3462 −4761 −3953 −4671 −4212 −3320 −3352 −3748 −3779−2839 −2981 −4004 −3668 −4222 163 — −149 −500 233 43 −381 399 106 −626210 −466 −720 275 394 45 96 359 117 −369 −294 −249 — −16 −7108 −8150−894 −1115 −701 −1378 * * 154(Y −3482 −2868 −3701 −3919 238 −3552 −1112−3000 −3638 −2516 −2526 −3027 −3772 −3101 −3341 −3418 −3527 −3071 −4414711 164 — −149 −500 233 43 −381 399 106 −626 210 −466 −720 275 394 4596 359 117 −369 −294 −249 — −16 −7108 −8150 −894 −1115 −701 −1378 * *155(S) 2313 −937 −2414 −2419 −3070 −1197 −2205 −2774 −2385 −3059 −2200−1614 −1936 −2106 −2436 2518 −728 −1846 −3302 −3046 165 — −149 −500 23343 −381 399 106 −626 210 −466 −720 275 394 45 96 359 117 −369 −294 −249— −16 −7108 −8150 −894 −1115 −701 −1378 * * 156(L) −2364 −1901 −4660−4144 −630 −4349 −3246 2015 −3856 2597 544 −4006 −3841 −3101 −3583 −3629−2275 2 −2255 −2227 166 — −149 −500 233 43 −381 399 106 −626 210 −466−720 275 394 45 96 359 117 −369 −294 −249 — −16 −7108 −8150 −894 −1115−701 −1378 * * 157(S) −643 −1153 −1942 −1769 −1726 −1574 −1553 −1424−1560 381 −1167 −1475 −2124 −1504 −1711 2968 −911 −1168 −2234 −1683 167— −149 −500 233 43 −381 399 106 −626 210 −466 −720 275 394 45 96 359 117−369 −294 −249 — −16 −7108 −8150 −894 −1115 −701 −1378 * * 158(H −1208−1519 −1818 −1600 −796 −2137 4436 −1042 −1134 −1422 −996 −1514 −2459−1277 −1260 −1442 −1296 1290 −1367 −527 168 — −149 −500 233 43 −381 399106 −626 210 −466 −720 275 394 45 96 359 117 −369 −294 −249 — −16 −7108−8150 −894 −1115 −701 −1378 * * 159(G 1625 −934 −2312 −2287 −3120 2515−2142 −2866 −2304 −3096 −2206 −1553 −1910 −2010 −2401 1405 −705 −1884−3324 −3069 169 — −149 −500 233 43 −381 399 106 −626 210 −466 −720 275394 45 96 359 117 −369 −294 −249 — −16 −7108 −8150 −894 −1115 −701−1378 * * 160(Y 553 −516 −2670 −2093 1648 −2153 −831 125 −1753 −275 301−1673 −2204 −1407 −1649 −1238 −604 1878 −648 2121 170 — −149 −500 233 43−381 399 106 −626 210 −466 −720 275 394 45 96 359 117 −369 −294 −249 —−16 −7108 −8150 −894 −1115 −701 −1378 * * 161(G −2594 −2690 −3304 −3623−4328 3747 −3462 −4761 −3953 −4671 −4212 −3320 −3352 −3748 −3779 −2839−2981 −4004 −3668 −4222 171 — −149 −500 233 43 −381 399 106 −626 210−466 −720 275 394 45 96 359 117 −369 −294 −249 — −16 −7108 −8150 −894−1115 −701 −1378 * * 162(A 3438 −1472 −2846 −3040 −3287 −1726 −2735−2840 −3028 −3257 −2662 −2236 −2447 −2798 −2944 −1216 −1387 −2183 −3405−3320 172 — −149 −500 233 43 −381 399 106 −626 210 −466 −720 275 394 4596 359 117 −369 −294 −249 — −16 −7108 −8150 −894 −1115 −701 −1378 * *163(I) −1759 −1304 −4329 −3967 −1748 −4050 −3739 3054 −3836 −593 −525−3728 −3874 −3686 −3907 −3367 −1751 2401 −3255 −2817 173 — −149 −500 23343 −381 399 106 −626 210 −466 −720 275 394 45 96 359 117 −369 −294 −249— −16 −7108 −8150 −894 −1115 −701 −1378 * * 164(M −2389 −1957 −4609−4018 1345 −4211 −2821 78 −3724 2123 3673 −3822 −3688 −2852 −3378 −3418−2267 −598 −1888 −1767 174 — −149 −500 233 43 −381 399 106 −626 210 −466−720 275 394 45 96 359 117 −369 −294 −249 — −16 −7108 −8150 −894 −1115−701 −1378 * * 165(D −2784 −3432 4016 −1200 −4140 −2466 −2197 −4505−2621 −4365 −3956 −1551 −3014 −2039 −3232 −2593 −2938 −4046 −3710 −3552175 — −149 −500 233 43 −381 399 106 −626 210 −466 −720 275 394 45 96 359117 −369 −294 −249 — −16 −7108 −8150 −894 −1115 −701 −1378 * * 166(N−2171 −2655 −1458 −1748 −3334 −2364 −2267 −3943 −2365 −3936 −3437 4205−2932 −2205 −2608 −2224 −2439 −3392 −3253 −2909 176 — −149 −500 233 43−381 399 106 −626 210 −466 −720 275 394 45 96 359 117 −369 −294 −249 —−16 −7108 −8150 −894 −1115 −701 −1378 * * 167(P) −2931 −2878 −3420 −3706−4181 −2925 −3468 −4621 −3859 −4490 −4165 −3491 4225 −3781 −3695 −3182−3279 −4087 −3594 −4064 177 — −149 −500 233 43 −381 399 106 −626 210−466 −720 275 394 45 96 359 117 −369 −294 −249 — −16 −7108 −8150 −894−1115 −701 −1378 * * 168(D −1220 −2896 2608 1191 −3149 −1530 −651 −2978−602 −2895 −2089 1257 −1925 −269 −1273 1237 −1229 −2498 −3083 −2233 178— −149 −500 233 43 −381 399 106 −626 210 −466 −720 275 394 45 96 359 117−369 −294 −249 — −16 −7108 −8150 −894 −1115 −701 −1378 * * 169(L) −1037−975 −2376 275 −735 −2518 −1412 367 −1669 2017 219 −1835 −2540 −1484−1766 −1625 −988 1640 −1541 −1207 179 — −149 −500 233 43 −381 399 106−626 210 −466 −720 275 394 45 96 359 117 −369 −294 −249 — −16 −7108−8150 −894 −1115 −701 −1378 * * 170(I) −1918 −1539 −4076 −3666 2083−3676 −2142 3117 −3379 145 94 −3221 −3504 −2843 −3198 −2911 −1872 334−1508 −773 180 — −149 −500 233 43 −381 399 106 −626 210 −466 −720 275394 45 96 359 117 −369 −294 −249 — −16 −7108 −8150 −894 −1115 −701−1378 * * 171(V 2267 −970 −2988 −2782 −1867 −1873 −2265 74 −2556 −1277−903 −2107 −2419 −2332 −2560 −1182 −982 2421 −2604 −2249 181 — −149 −500233 43 −381 399 106 −626 210 −466 −720 275 394 45 96 359 117 −369 −294−249 — −16 −7108 −8150 −894 −1115 −701 −1378 * * 172(A 2401 −935 −2092−1865 −2596 −1235 −1739 −2211 −1758 −2497 −1687 −1386 1817 −1571 −1946−528 1549 −1545 −2846 −2512 182 — −149 −500 233 43 −381 399 106 −626 210−466 −720 275 394 45 96 359 117 −369 −294 −249 — −16 −7108 −8150 −894−1115 −701 −1378 * * 173(C 152 3737 −3346 −3008 −1521 −2075 −2187 405−2700 −983 −575 −2269 −2516 −2413 −2614 −1349 −959 2580 −2260 −1908 183— −149 −500 233 43 −381 399 106 −626 210 −466 −720 275 394 45 96 359 117−369 −294 −249 — −16 −7108 −8150 −894 −1115 −701 −1378 * * 174(V −1189−1030 −2667 1142 −1294 −2870 −1904 1998 −2055 −599 −276 −2175 −2880−1914 −2228 −1998 −1157 2462 −2134 −1721 184 — −149 −500 233 43 −381 399106 −626 210 −466 −720 275 394 45 96 359 117 −369 −294 −249 — −16 −7108−8150 −894 −1115 −701 −1378 * * 175(V −1753 −1297 −4327 −3965 −1769−4049 −3747 2530 −3837 −621 −545 −3725 −3875 −3695 −3913 −3366 −17452911 −3274 −2827 185 — −149 −500 233 43 −381 399 106 −626 210 −466 −720275 394 45 96 359 117 −369 −294 −249 — −16 −7108 −8150 −894 −1115 −701−1378 * * 176(G −2594 −2690 −3304 −3623 −4328 3747 −3462 −4761 −3953−4671 −4212 −3320 −3352 −3748 −3779 −2839 −2981 −4004 −3668 −4222 186 —−149 −500 233 43 −381 399 106 −626 210 −466 −720 275 394 45 96 359 117−369 −294 −249 — −16 −7108 −8150 −894 −1115 −701 −1378 * * 177(D −2784−3432 4016 −1200 −4140 −2466 −2197 −4505 −2621 −4365 −3956 −1551 −3014−2039 −3232 −2593 −2938 −4046 −3710 −3552 187 — −149 −500 233 43 −381399 106 −626 210 −466 −720 275 394 45 96 359 117 −369 −294 −249 — −16−7108 −8150 −894 −1115 −701 −1378 * * 178(G −2594 −2690 −3304 −3623−4328 3747 −3462 −4761 −3953 −4671 −4212 −3320 −3352 −3748 −3779 −2839−2981 −4004 −3668 −4222 188 — −149 −500 233 43 −381 399 106 −626 210−466 −720 275 394 45 96 359 117 −369 −294 −249 — −16 −7108 −8150 −894−1115 −701 −1378 * * 179(E) −2641 −3308 −896 3732 −3966 −2458 −2043−4105 −2128 −4016 −3555 −1531 −2959 −1842 −2560 −2479 −2750 −3722 −3563−3385 189 — −149 −500 233 43 −381 399 106 −626 210 −466 −720 275 394 4596 359 117 −369 −294 −249 — −16 −7108 −8150 −894 −1115 −701 −1378 * *180(A 3124 −934 −2490 −2562 −3082 −1203 −2297 −2766 −2535 −3081 −2234−1670 −1954 −2236 −2534 920 −746 −1844 −3332 −3091 190 — −149 −500 23343 −381 399 106 −626 210 −466 −720 275 394 45 96 359 117 −369 −294 −249— −16 −7108 −8150 −894 −1115 −701 −1378 * * 181(E) −2641 −3308 −896 3732−3966 −2458 −2043 −4105 −2128 −4016 −3555 −1531 −2959 −1842 −2560 −2479−2750 −3722 −3563 −3385 191 — −149 −500 233 43 −381 399 106 −626 210−466 −720 275 394 45 96 359 117 −369 −294 −249 — −16 −7108 −8150 −894−1115 −701 −1378 * * 182(T) −1213 −1674 −2755 −2906 −3163 −1922 −2659−2698 −2788 −3105 −2612 −2311 −2600 −2708 −2753 −1463 3819 −2197 −3286−3156 192 — −149 −500 233 43 −381 399 106 −626 210 −466 −720 275 394 4596 359 117 −369 −294 −249 — −16 −7108 −8150 −894 −1115 −701 −1378 * *183(G 1080 −1108 −2311 −2509 −3336 3223 −2424 −3074 −2706 −3361 −2521−1751 −2082 −2372 −2708 −729 −932 −2089 −3493 −3324 193 — −149 −500 23343 −381 399 106 −626 210 −466 −720 275 394 45 96 359 117 −369 −294 −249— −16 −7108 −8150 −894 −1115 −701 −1378 * * 184(P) −2931 −2878 −3420−3706 −4181 −2925 −3468 −4621 −3859 −4490 −4165 −3491 4225 −3781 −3695−3182 −3279 −4087 −3594 −4064 194 — −149 −500 233 43 −381 399 106 −626210 −466 −720 275 394 45 96 359 117 −369 −294 −249 — −16 −7108 −8150−894 −1115 −701 −1378 * * 185(L) −1369 −1384 −3092 −2737 −825 −2649−2073 −44 −2334 2571 187 −2437 −2847 −2125 −2306 −1915 1278 −290 −1941−1678 195 — −149 −500 233 43 −381 399 106 −626 210 −466 −720 275 394 4596 359 117 −369 −294 −249 — −16 −7108 −8150 −894 −1115 −701 −1378 * *186(A 2912 −1000 −2422 −2157 −1636 −1634 −1753 −816 −1876 −1128 1988−1694 −2169 −1741 −1956 −923 −861 −675 −2256 −1899 196 — −149 −500 23343 −381 399 106 −626 210 −466 −720 275 394 45 96 359 117 −369 −294 −249— −16 −7108 −8150 −894 −1115 −701 −1378 * * 187(T) 973 −953 −2483 −2484−2838 −1268 −2195 −2209 −2352 −2704 −1971 −1675 −1991 −2131 −2373 −6173427 −1554 −3148 −2888 197 — −149 −500 233 43 −381 399 106 −626 210 −466−720 275 394 45 96 359 117 −369 −294 −249 — −16 −7108 −8150 −894 −1115−701 −1378 * * 188(S) −437 −1083 −2006 −2144 −3262 1583 −2197 −3097−2380 −3307 −2434 −1562 −2008 −2077 −2485 2965 −857 −2074 −3426 −3160198 — −149 −500 233 43 −381 399 106 −626 210 −466 −720 275 394 45 96 359117 −369 −294 −249 — −16 −7108 −8150 −894 −1115 −701 −1378 * * 189(W−4114 −3274 −4214 −4453 −1722 −3496 −2681 −4109 −4149 −3619 −3615 −4044−3885 −4032 −3816 −4355 −4248 −4133 6191 −1329 199 — −149 −500 233 43−381 399 106 −626 210 −466 −720 275 394 45 96 359 117 −369 −294 −249 —−16 −7108 −8150 −894 −1115 −701 −1378 * * 190(H −1323 −1832 −1402 −9942149 −2268 3183 −1595 −684 −1541 −1023 −1062 −2358 2478 −951 −1335 −1257−1461 −476 569 200 — −149 −500 233 43 −381 399 106 −626 210 −466 −720275 394 45 96 359 117 −369 −294 −249 — −16 −7108 −8150 −894 −1115 −701−1378 * * 191(S) 1326 −873 −2274 −2002 −2263 −1287 −1735 −1644 −1844−2124 −1388 −1463 −1915 −1637 −1990 2623 −646 880 −2605 −2269 201 — −149−500 233 43 −381 399 106 −626 210 −466 −720 275 394 45 96 359 117 −369−294 −249 — −16 −7108 −8150 −894 −1115 −701 −1378 * * 192(N −573 −1630864 62 −1860 −1478 −310 843 −39 −1634 −837 2440 −1658 65 −526 −537 638−1154 −1980 −1380 202 — −149 −500 233 43 −381 399 106 −626 210 −466 −720275 394 45 96 359 117 −369 −294 −249 — −16 −7108 −8150 −894 −1115 −701−1378 * * 193(K −1324 −1987 −1657 −1059 −2437 −2134 −750 −1568 3217−1940 −1374 −1107 −2304 −391 150 −1379 −1277 548 −2320 −1952 203 — −149−500 233 43 −381 399 106 −626 210 −466 −720 275 394 45 96 359 117 −369−294 −249 — −16 −7108 −8150 −894 −1115 −701 −1378 * * 194(H −30 439 11363 −394 −739 699 −414 463 −757 501 286 −577 639 165 −23 111 −312 697−25 204 — −149 −500 233 43 −381 399 106 −626 210 −466 −720 275 394 45 96359 117 −369 −294 −249 — −16 −7108 −8150 −894 −1115 −701 −1378 * *195(F) −2721 −2160 −3990 −3906 3360 −3716 −572 −1433 −3510 1177 −922−2674 −3597 −2614 −3108 −2899 −2622 −1671 137 2722 205 — −149 −500 23343 −381 399 106 −626 210 −466 −720 275 394 45 96 359 117 −369 −294 −249— −16 −7108 −8150 −894 −1115 −701 −1378 * * 196(I) −1769 −1321 −4308−3881 −1430 −3998 −3403 2941 −3713 744 −240 −3637 −3769 −3419 −3696−3267 −1740 2073 −2864 −2543 206 — −149 −500 233 43 −381 399 106 −626210 −466 −720 275 394 45 96 359 117 −369 −294 −249 — −16 −7108 −8150−894 −1115 −701 −1378 * * 197(N −1660 −3287 1909 69 −3610 −1646 −1046−3616 −1275 −3528 −2867 3539 −2186 −731 −2069 −1373 −1757 −3086 −3624−2697 207 — −149 −500 233 43 −381 399 106 −626 210 −466 −720 275 394 4596 359 117 −369 −294 −249 — −16 −7108 −8150 −894 −1115 −701 −1378 * *198(P) −2931 −2878 −3420 −3706 −4181 −2925 −3468 −4621 −3859 −4490 −4165−3491 4225 −3781 −3695 −3182 −3279 −4087 −3594 −4064 208 — −149 −500 23343 −381 399 106 −626 210 −466 −720 275 394 45 96 359 117 −369 −294 −249— −16 −7108 −8150 −894 −1115 −701 −1378 * * 199(R 780 −954 −1042 −463−1021 −1681 −388 1232 838 −838 −132 −612 −1756 −173 1322 −665 −418 574−1339 −893 209 — −149 −500 233 43 −381 399 106 −626 210 −466 −720 275394 45 96 359 117 −369 −294 −249 — −16 −7108 −8150 −894 −1115 −701−1378 * * 200(N −622 −2053 −110 1285 −2366 −1450 −199 −2102 1009 −2062−1176 2124 −1614 238 −276 −491 1247 −1677 −2241 −1566 210 — −149 −500233 43 −381 399 106 −626 210 −466 −720 275 394 45 96 359 117 −369 −294−249 — −16 −7108 −8150 −894 −1115 −701 −1378 * * 201(D −1369 −2674 3374−58 −3453 −1571 −1095 −3380 −1289 −3368 −2659 −394 −2124 −784 −2016 1149−1529 −2785 −3505 −2662 211 — −149 −500 233 43 −381 399 106 −626 210−466 −720 275 394 45 96 359 117 −369 −294 −249 — −16 −7108 −8150 −894−1115 −701 −1378 * * 202(G −2594 −2690 −3304 −3623 −4328 3747 −3462−4761 −3953 −4671 −4212 −3320 −3352 −3748 −3779 −2839 −2981 −4004 −3668−4222 212 — −149 −500 233 43 −381 399 106 −626 210 −466 −720 275 394 4596 359 117 −369 −294 −249 — −16 −7108 −8150 −894 −1115 −701 −1378 * *203(A 2246 −790 −2416 −1988 −1270 −1821 −1490 1726 −1755 −905 −386 −1651−2194 −1557 −1854 −1027 949 146 −1839 −1474 213 — −149 −500 233 43 −381399 106 −626 210 −466 −720 275 394 45 96 359 117 −369 −294 −249 — −16−7108 −8150 −894 −1115 −701 −1378 * * 204(V −1771 −1603 −3750 −3689−2037 −3050 −3231 403 −3479 −1154 −1076 −3246 −3399 −3383 −3437 −2628−1917 3536 −3074 −2677 214 — −149 −500 233 43 −381 399 106 −626 210 −466−720 275 394 45 96 359 117 −369 −294 −249 — −16 −7108 −8150 −894 −1115−701 −1378 * * 205(L) −2871 −2457 −4231 −4103 −1033 −3803 −3165 −541−3734 3130 −31 −3935 −3797 −3286 −3484 −3713 −2869 −1136 −2394 −2220 215— −149 −500 233 43 −381 399 106 −626 210 −466 −720 275 394 45 96 359 117−369 −294 −249 — −16 −7108 −8150 −894 −1115 −701 −1378 * * 206(P) −2931−2878 −3420 −3706 −4181 −2925 −3468 −4621 −3859 −4490 −4165 −3491 4225−3781 −3695 −3182 −3279 −4087 −3594 −4064 216 — −149 −500 233 43 −381399 106 −626 210 −466 −720 275 394 45 96 359 117 −369 −294 −249 — −16−7108 −8150 −894 −1115 −701 −1378 * * 207(I) −2091 −1746 −3971 −3840−1676 −3532 −3289 3684 −3581 −659 −693 −3562 −3674 −3445 −3521 −3194−2146 449 −2877 −2493 217 — −149 −500 233 43 −381 399 106 −626 210 −466−720 275 394 45 96 359 117 −369 −294 −249 — −16 −7108 −8150 −894 −1115−701 −1378 * * 208(L) −2475 −2006 −4716 −4195 −570 −4423 −3262 1353−3887 2819 603 −4084 −3871 −3089 −3590 −3715 −2377 −194 −2218 −2208 218— −149 −500 233 43 −381 399 106 −626 210 −466 −720 275 394 45 96 359 117−369 −294 −249 — −16 −7108 −8150 −894 −1115 −701 −1378 * * 209(H −1047−2367 −130 −12 −2443 −1653 3422 −2425 11 −2366 −1567 2352 −1902 1348−351 −897 −1003 −2040 −2389 −1693 219 — −149 −500 233 43 −381 399 106−626 210 −466 −720 275 394 45 96 359 117 −369 −294 −249 — −16 −7108−8150 −894 −1115 −701 −1378 * * 210(L) −1968 −1597 −4244 −3772 −812−3841 −2955 582 −3473 2391 322 −3529 −3600 −2960 −3315 −3097 −1926 2070−2269 −2100 220 — −149 −500 233 43 −381 399 106 −626 210 −466 −720 275394 45 96 359 117 −369 −294 −249 — −16 −7108 −8150 −894 −1115 −701−1378 * * 211(N −2171 −2655 −1458 −1748 −3334 −2364 −2267 −3943 −2365−3936 −3437 4205 −2932 −2205 −2608 −2224 −2439 −3392 −3253 −2909 221 —−149 −500 233 43 −381 399 106 −626 210 −466 −720 275 394 45 96 359 117−369 −294 −249 — −16 −7108 −8150 −894 −1115 −701 −1378 * * 212(G −2594−2690 −3304 −3623 −4328 3747 −3462 −4761 −3953 −4671 −4212 −3320 −3352−3748 −3779 −2839 −2981 −4004 −3668 −4222 222 — −149 −500 233 43 −381399 106 −626 210 −466 −720 275 394 45 96 359 117 −369 −294 −249 — −16−7108 −8150 −894 −1115 −701 −1378 * * 213(F) −3581 −2688 −4165 −44013865 −4034 −401 −2491 −3981 −1903 −1944 −2746 −3921 −2847 −3438 −3284−3462 −2647 341 3054 223 — −149 −500 233 43 −381 399 106 −626 210 −466−720 275 394 45 96 359 117 −369 −294 −249 — −16 −7108 −8150 −894 −1115−701 −1378 * * 214(K −2620 −2961 −2461 −2046 −3743 −2791 −1570 −36033784 −3387 −2839 −2048 −3039 −1260 −465 −2604 −2536 −3331 −3001 −2988224 — −149 −500 233 43 −381 399 106 −626 210 −466 −720 275 394 45 96 359117 −369 −294 −249 — −16 −7108 −8150 −894 −1115 −701 −1378 * * 215(I)−2091 −1746 −3971 −3840 −1676 −3532 −3289 3684 −3581 −659 −693 −3562−3674 −3445 −3521 −3194 −2146 449 −2877 −2493 225 — −149 −500 233 43−381 399 106 −626 210 −466 −720 275 394 45 96 359 117 −369 −294 −249 —−16 −7108 −8150 −894 −1115 −701 −1378 * * 216(A 2478 −935 −2423 −2429−3066 −1197 −2208 −2769 −2392 −3055 −2196 −1617 −1936 −2112 −2440 2351−728 −1843 −3300 −3045 226 — −149 −500 233 43 −381 399 106 −626 210 −466−720 275 394 45 96 359 117 −369 −294 −249 — −16 −7108 −8150 −894 −1115−701 −1378 * * 217(N −1558 −3098 310 1592 −3431 −1657 −945 −3340 −959−3271 −2572 3495 −2146 −611 −1578 −1301 −1621 −2860 −3383 −2547 227 —−149 −500 233 43 −381 399 106 −626 210 −466 −720 275 394 45 96 359 117−369 −294 −249 — −16 −7108 −8150 −894 −1115 −701 −1378 * * 218(P) −1664−2231 −2030 −1695 −3192 −2240 −1444 −3029 −556 −2975 −2319 −1668 3549−1149 1833 −1745 −1774 −2613 −2848 −2650 228 — −149 −500 233 43 −381 399106 −626 210 −466 −720 275 394 45 96 359 117 −369 −294 −249 — −16 −7108−8150 −894 −1115 −701 −1378 * * 219(T) −1213 −1674 −2755 −2906 −3163−1922 −2659 −2698 −2788 −3105 −2612 −2311 −2600 −2708 −2753 −1463 3819−2197 −3286 −3156 229 — −149 −500 233 43 −381 399 106 −626 210 −466 −720275 394 45 96 359 117 −369 −294 −249 — −16 −7108 −8150 −894 −1115 −701−1378 * * 220(I) −1764 −1326 −4294 −3932 −1658 −3987 −3644 3354 −3776−498 −454 −3684 −3833 −3599 −3826 −3303 −1760 1799 −3153 −2738 230 —−149 −500 233 43 −381 399 106 −626 210 −466 −720 275 394 45 96 359 117−369 −294 −249 — −16 −7108 −8150 −894 −1115 −701 −1378 * * 221(F) −2604−2127 −4552 −4135 2542 −4236 −2203 −115 −3820 2542 500 −3692 −3785 −2927−3457 −3508 −2493 −769 −1337 −643 231 — −149 −500 233 43 −381 399 106−626 210 −466 −720 275 394 45 96 359 117 −369 −294 −249 — −16 −7108−8150 −894 −1115 −701 −1378 * * 222(S) 846 −947 −2243 −2217 −3137 1905−2112 −2888 −2254 −3112 −2218 −1528 −1909 −1968 −2369 2545 −708 −1899−3331 −3067 232 — −149 −500 233 43 −381 399 106 −626 210 −466 −720 275394 45 96 359 117 −369 −294 −249 — −16 −7108 −8150 −894 −1115 −701−1378 * * 223(R −1454 3144 −2763 −2070 −2728 −2193 −1414 −2383 −460−2518 −1907 −1827 −2567 −1160 3510 −1626 −1582 −2068 −2596 −2366 233 —−149 −500 233 43 −381 399 106 −626 210 −466 −720 275 394 45 96 359 117−369 −294 −249 — −16 −7108 −8150 −894 −1115 −701 −1378 * * 224(M −434−912 −967 653 −960 −1640 −368 1179 682 −787 2592 −569 −1718 −161 −575−617 633 −341 −1294 −841 234 — −149 −500 233 43 −381 399 106 −626 210−466 −720 275 394 45 96 359 117 −369 −294 −249 — −16 −7108 −8150 −894−1115 −701 −1378 * * 225(S) −1102 −2199 1764 −235 −3206 −1518 −1117−3089 −1203 −3129 −2368 −513 −2060 −804 −1816 2841 −1292 −2470 −3271−2541 235 — −149 −500 233 43 −381 399 106 −626 210 −466 −720 275 394 4596 359 117 −369 −294 −249 — −16 −7108 −8150 −894 −1115 −701 −1378 * *226(D −1724 −3448 3411 103 −3726 −1642 −1058 −3734 −1342 −3628 −29911884 −2196 −745 −2191 −1408 −1822 −3197 −3743 −2768 236 — −149 −500 23343 −381 399 106 −626 210 −466 −720 275 394 45 96 359 117 −369 −294 −249— −16 −7108 −8150 −894 −1115 −701 −1378 * * 227(E) 391 −2060 −303 2460−2453 −1565 −312 −2145 213 −2119 −1272 −258 −1745 110 1394 −657 −720−1747 −2290 −1683 237 — −149 −500 233 43 −381 399 106 −626 210 −466 −720275 394 45 96 359 117 −369 −294 −249 — −16 −7108 −8150 −894 −1115 −701−1378 * * 228(E) −843 −2213 −113 2617 −2562 −1553 −357 −2268 1012 −2237−1392 −212 −1769 60 −324 −706 776 −1863 −2412 −1764 238 — −149 −500 23343 −381 399 106 −626 210 −466 −720 275 394 45 96 359 117 −369 −294 −249— −16 −7108 −8150 −894 −1115 −701 −1378 * * 229(L) −2324 −1864 −4634−4121 −657 −4319 −3239 2224 −3838 2493 517 −3975 −3830 −3106 −3578 −3596−2239 73 −2272 −2231 239 — −149 −500 233 43 −381 399 106 −626 210 −466−720 275 394 45 96 359 117 −369 −294 −249 — −16 −7108 −8150 −894 −1115−701 −1378 * * 230(H −505 −1236 −775 −228 −1373 −1593 2318 −963 872−1178 −425 −432 −1693 14 −290 −578 1743 825 −1578 −1083 240 — −149 −500233 43 −381 399 106 −626 210 −466 −720 275 394 45 96 359 117 −369 −294−249 — −16 −7108 −8150 −894 −1115 −701 −1378 * * 231(C −561 2259 14491476 −2294 −1417 −164 −2034 1472 −2003 −1111 −57 −1572 275 −300 −433−510 −1609 −2194 −1510 241 — −149 −500 233 43 −381 399 106 −626 210 −466−720 275 394 45 96 359 117 −369 −294 −249 — −16 −7108 −8150 −894 −1115−701 −1378 * * 232(Y −2882 −2267 −4018 −3995 2580 −3778 −511 −1658 −3593923 −1152 −2675 −3663 −2654 −3169 −2969 −2779 −1865 205 3751 242 — −149−500 233 43 −381 399 106 −626 210 −466 −720 275 394 45 96 359 117 −369−294 −249 — −16 −7108 −8150 −894 −1115 −701 −1378 * * 233(F) −3342 −2776−4026 −4232 4354 −3545 −1431 −2315 −4038 −1801 −1900 −3299 −3780 −3350−3645 −3490 −3420 −2566 −739 349 243 — −149 −500 233 43 −381 399 106−626 210 −466 −720 275 394 45 96 359 117 −369 −294 −249 — −16 −7108−8150 −894 −1115 −701 −1378 * * 234(H −559 −1906 −319 1741 −2211 −14782491 −1923 355 −1899 −1021 −132 −1591 303 791 −452 1019 −1527 −2083−1454 244 — −149 −500 233 43 −381 399 106 −626 210 −466 −720 275 394 4596 359 117 −369 −294 −249 — −16 −7108 −8150 −894 −1115 −701 −1378 * *235(G −456 −1098 −1993 −2173 −3296 2968 −2244 −3141 −2461 −3355 −2485−1583 −2025 −2139 −2549 1723 −881 −2104 −3461 −3203 245 — −149 −500 23343 −381 399 106 −626 210 −466 −720 275 394 45 96 359 117 −369 −294 −249— −16 −7108 −8150 −894 −1115 −701 −1378 * * 236(M −1532 −1301 −3405−2864 −57 −3050 −1438 −56 −2477 1096 3967 −2484 −2939 −2042 −2342 −2169−1455 −370 −989 2079 246 — −149 −500 233 43 −381 399 106 −626 210 −466−720 275 394 45 96 359 117 −369 −294 −249 — −16 −7108 −8150 −894 −1115−701 −1378 * * 237(G −1038 −1765 −926 −1191 −3372 3233 −1826 −3379 −1926−3481 −2725 1285 −2271 −1628 −2264 −1145 −1377 −2554 −3401 −2980 247 —−149 −500 233 43 −381 399 106 −626 210 −466 −720 275 394 45 96 359 117−369 −294 −249 — −16 −7108 −8150 −894 −1115 −701 −1378 * * 238(W −3553−2695 −4100 −4288 1022 −3972 −428 −2592 −3792 −2021 −2038 −2737 −3890−2815 −3323 −3265 −3440 −2712 4944 3677 248 — −149 −500 233 43 −381 399106 −626 210 −466 −720 275 394 45 96 359 117 −369 −294 −249 — −16 −7108−8150 −894 −1115 −701 −1378 * * 239(H −693 −2112 −279 1837 −2456 −15342434 −2176 1108 −2098 −1217 −167 −1666 1691 −39 −560 −624 −1753 −2235−1604 249 — −149 −500 233 43 −381 399 106 −626 210 −466 −720 275 394 4596 359 117 −369 −294 −249 — −16 −7108 −8150 −894 −1115 −701 −1378 * *240(P) −853 −1252 −2460 −2393 −2139 −1784 −2109 −974 −2210 −1748 −1364−1924 3453 −2108 −2271 −1167 −1152 1448 −2678 −2307 250 — −149 −500 23343 −381 399 106 −626 210 −466 −720 275 394 45 96 359 117 −369 −294 −249— −812 −7108 −1241 −894 −1115 −701 −1378 * * 241(Y −906 −1365 −1255 −688−4 −1806 −48 −1150 314 −1157 −604 −702 −1897 −107 2106 −965 −822 −1011−491 2916 251 — −149 −500 233 43 −381 399 106 −626 210 −466 −720 275 39445 96 359 117 −369 −294 −249 — −27 −6323 −7365 −894 −1115 −292 −2448 * *242(Y −476 −775 −1198 1077 −755 −1738 −505 1586 −528 −626 43 −777 −1822−410 −817 −751 649 −143 −1165 1945 252 — −149 −500 233 43 −381 399 106−626 210 −466 −720 275 394 45 96 359 117 −369 −294 −249 — −16 −7108−8150 −894 −1115 −701 −1378 * * 243(F) −1857 −1592 −3755 −3460 3638−3255 −1454 −16 −3144 −214 −206 −2800 −3287 −2604 −2951 −2505 −1863 1480−853 99 253 — −149 −500 233 43 −381 399 106 −626 210 −466 −720 275 39445 96 359 117 −369 −294 −249 — −16 −7108 −8150 −894 −1115 −701 −1378 * *244(V −1203 −1434 −1278 1166 −1756 −2236 −1499 75 −1412 −1192 −819 −1390−2525 −1332 −1696 −1574 −1248 2962 −2384 −1907 254 — −149 −500 233 43−381 399 106 −626 210 −466 −720 275 394 45 96 359 117 −369 −294 −249 —−16 −7108 −8150 −894 −1115 −701 −1378 * * 245(H −30 439 11 363 −394 −739699 −414 463 −757 501 286 −577 639 165 −23 111 −312 697 −25 255 — −149−500 233 43 −381 399 106 −626 210 −466 −720 275 394 45 96 359 117 −369−294 −249 — −16 −7108 −8150 −894 −1115 −701 −1378 * * 246(E) 1028 −22301464 1545 −2560 −1444 −343 −2324 −77 −2285 −1411 −93 −1690 78 −635 1220−730 −1876 −2478 −1750 256 — −149 −500 233 43 −381 399 106 −626 210 −466−720 275 394 45 96 359 117 −369 −294 −249 — −16 −7108 −8150 −894 −1115−701 −1378 * * 247(G 802 −892 −1664 −1291 −1774 2148 −1181 −1363 −1177617 −906 −1109 −1839 −1027 −1436 836 −560 −1000 −2098 −1700 257 — −149−500 233 43 −381 399 106 −626 210 −466 −720 275 394 45 96 359 117 −369−294 −249 — −16 −7108 −8150 −894 −1115 −701 −1378 * * 248(F) −737 −17101482 1223 2205 −1628 −301 −1513 −202 −1603 −865 −339 −1790 −72 −681 −695−688 −1259 −1410 1271 258 — −149 −500 233 43 −381 399 106 −626 210 −466−720 275 394 45 96 359 117 −369 −294 −249 — −16 −7108 −8150 −894 −1115−701 −1378 * * 249(D −1662 −3241 3494 12 −3550 −1708 −991 −3449 907−3360 −2675 −360 −2197 −658 −1631 −1384 −1715 −2975 −3451 −2636 259 —−149 −500 233 43 −381 399 106 −626 210 −466 −720 275 394 45 96 359 117−369 −294 −249 — −16 −7108 −8150 −894 −1115 −701 −1378 * * 250(K 374−1824 783 927 −2121 −1368 −40 525 1057 −1830 −920 824 249 411 −141 −290−342 −1433 −2020 −1349 260 — −149 −500 233 43 −381 399 106 −626 210 −466−720 275 394 45 96 359 117 −369 −294 −249 — −16 −7108 −8150 −894 −1115−701 −1378 * * 251(E) 424 −2247 1450 1906 −2557 209 −314 −2325 −37 −2276−1395 −75 659 111 −595 −584 −710 −1874 −2461 −1729 261 — −149 −500 23343 −381 399 106 −626 210 −466 −720 275 394 45 96 359 117 −369 −294 −249— −570 −7108 −1648 −894 −1115 −701 −1378 * * 252(D −1129 −2752 2889 513−3030 −1216 −532 −2959 −669 −2896 −2188 2229 −1714 −198 −1413 −860 −1196−2465 −3041 −2140 262 — −149 −500 233 43 −379 399 105 −627 212 −466 −721275 394 45 96 359 117 −370 −295 −248 — −754 −2619 −2035 −2949 −200 −992−1008 * * 253(H −696 −961 −1261 −873 −178 −1785 3652 1381 −427 −516 −92−889 −1934 −521 −602 −945 −673 −203 −756 22 273 — −149 −500 233 43 −381399 106 −626 210 −466 −720 275 394 45 96 359 117 −369 −294 −249 — −25−6457 −7499 −894 −1115 −1666 −546 * * 254(M −1561 −1309 −3310 −2786 −99−3163 −1984 569 −2364 1604 3948 −2656 −2936 −1983 −2284 −2361 −1493 116−1472 −1272 274 — −149 −500 233 43 −381 399 106 −626 210 −466 −720 275394 45 96 359 117 −369 −294 −249 — −25 −6457 −7499 −894 −1115 −777−1263 * * 255(K −475 −1891 −137 1054 −2221 −1359 −30 −1946 1632 −1890−999 2 −1483 1488 30 1135 −411 −1523 −2049 −1403 275 — −149 −500 233 43−381 399 106 −626 210 −466 −720 275 394 45 96 359 117 −369 −294 −249 —−19 −6850 −7893 −894 −1115 −1215 −813 * * 256(V −1531 −1105 −4020 −3576−1227 −3695 −3034 2323 −3387 793 −62 −3320 −3500 −3101 −3368 −2941 −15012608 −2576 −2243 276 — −149 −500 233 43 −381 399 106 −626 210 −466 −720275 394 45 96 359 117 −369 −294 −249 — −19 −6850 −7893 −894 −1115 −1215−813 * * 257(H −1244 −2186 −246 −319 −1501 −1694 4400 −2492 −417 −2436−1795 1396 −2075 −501 −711 −1152 −1294 −2140 −1842 −960 277 — −149 −500233 43 −381 399 106 −626 210 −466 −720 275 394 45 96 359 117 −369 −294−249 — −19 −6850 −7893 −894 −1115 −1215 −813 * * 258(R −675 −1969 −2421673 −2340 −1479 −164 −2032 420 −1985 −1141 −153 1471 261 1760 −560 −613−1643 −2136 −1550 278 — −149 −500 233 43 −381 399 106 −626 210 −466 −720275 394 45 96 359 117 −369 −294 −249 — −19 −6850 −7893 −894 −1115 −453−1893 * * 259(E) 377 −1835 1113 1421 −2128 −1382 −69 −1857 329 −1840−939 −29 −1493 377 1329 −322 −374 19 −2039 −1371 279 — −149 −500 233 43−381 399 106 −626 210 −466 −720 275 394 45 96 359 117 −369 −294 −249 —−16 −7108 −8150 −894 −1115 −701 −1378 * * 260(M −2315 −1899 −4526 −39412102 −4105 −2681 70 −3638 1954 1509 −3704 −3629 −2798 −3304 −3301 −2198−582 −1802 −1604 280 — −149 −500 233 43 −381 399 106 −626 210 −466 −720275 394 45 96 359 117 −369 −294 −249 — −16 −7108 −8150 −894 −1115 −701−1378 * * 261(A 2818 −1372 −1321 −1214 −2015 −1557 2623 −2096 −1108−2284 −1581 −1154 −2074 −1121 −1340 −881 −964 −1649 −2321 −1711 281 —−149 −500 233 43 −381 399 106 −626 210 −466 −720 275 394 45 96 359 117−369 −294 −249 — −16 −7108 −8150 −894 −1115 −701 −1378 * * 262(K −793−2177 −220 1469 −2548 −1561 −289 −2263 2325 −2196 −1334 −214 −1738 141−150 898 −737 −1844 −2341 −1711 282 — −149 −500 233 43 −381 399 106 −626210 −466 −720 275 394 45 96 359 117 −369 −294 −249 — −16 −7108 −8150−894 −1115 −701 −1378 * * 263(A 1931 −776 −2058 −1612 −1165 −1647 −1206−433 −1382 945 −310 −1370 −2014 −1216 −1530 −832 1640 −293 −1672 −1305283 — −149 −500 233 43 −381 399 106 −626 210 −466 −720 275 394 45 96 359117 −369 −294 −249 — −16 −7108 −8150 −894 −1115 −701 −1378 * * 264(M−1519 −1247 −3637 −3077 1725 −3081 −1493 −37 −2718 1089 3901 −2600 −2950−2153 −2487 −2201 −1437 −379 1806 −356 284 — −149 −500 233 43 −381 399106 −626 210 −466 −720 275 394 45 96 359 117 −369 −294 −249 — −16 −7108−8150 −894 −1115 −701 −1378 * * 265(D −1378 −3094 2801 1763 −3349 −1556−771 −3202 −821 −3114 −2349 −164 −2006 −409 −1544 1050 −1411 −2709 −3307−2411 285 — −149 −500 233 43 −381 399 106 −626 210 −466 −720 275 394 4596 359 117 −369 −294 −249 — −16 −7108 −8150 −894 −1115 −701 −1378 * *266(W −426 −1591 −384 832 −1812 −1435 −111 −1488 966 −1565 −720 −131−1532 300 −184 757 1423 −1162 2539 −1242 286 — −149 −500 233 43 −381 399106 −626 210 −466 −720 275 394 45 96 359 117 −369 −294 −249 — −16 −7108−8150 −894 −1115 −701 −1378 * * 267(V 1401 −623 −2516 −1981 −808 −2086−1255 1461 −1718 −518 36 −1694 −2253 −1472 −1752 293 −658 1939 −1375−1008 287 — −149 −500 233 43 −381 399 106 −626 210 −466 −720 275 394 4596 359 117 −369 −294 −249 — −16 −7108 −8150 −894 −1115 −701 −1378 * *268(W −857 −644 −3104 −2515 1895 −2435 −1142 1168 −2142 −39 357 −2021−2440 −1737 −1961 −1534 −797 2161 2512 −335 288 — −149 −500 233 43 −381399 106 −626 210 −466 −720 275 394 45 96 359 117 −369 −294 −249 — −16−7108 −8150 −894 −1115 −701 −1378 * * 269(E) −1213 −2845 1928 2618 −3115−1534 −660 −2926 −607 −2864 −2064 −150 −1929 −281 −1267 −980 833 −2457−3061 −2225 289 — −149 −500 233 43 −381 399 106 −626 210 −466 −720 275394 45 96 359 117 −369 −294 −249 — −16 −7108 −8150 −894 −1115 −701−1378 * * 270(E) −1357 −2719 −146 2868 −3119 −1782 −634 −2833 1719 −2718−1948 −434 −2077 −242 −361 −1166 −1309 −2433 −2790 −2201 290 — −149 −500233 43 −381 399 106 −626 210 −466 −720 275 394 45 96 359 117 −369 −294−249 — −16 −7108 −8150 −894 −1115 −701 −1378 * * 271(I) −2091 −1746−3971 −3840 −1676 −3532 −3289 3684 −3581 −659 −693 −3562 −3674 −3445−3521 −3194 −2146 449 −2877 −2493 291 — −149 −500 233 43 −381 399 106−626 210 −466 −720 275 394 45 96 359 117 −369 −294 −249 — −16 −7108−8150 −894 −1115 −701 −1378 * * 272(C −1095 2832 −1254 −506 −2502 −19691775 −2085 2238 −2024 −1241 −660 −2004 96 1706 −1025 −959 −1790 −2126−1723 292 — −149 −500 233 43 −381 399 106 −626 210 −466 −720 275 394 4596 359 117 −369 −294 −249 — −16 −7108 −8150 −894 −1115 −701 −1378 * *273(D 1682 −2499 2383 115 −3011 −1503 −717 −2803 −660 −2789 −1985 1727−1918 −347 −1292 −922 −1145 −2313 −2999 −2214 293 — −149 −500 233 43−381 399 106 −626 210 −466 −720 275 394 45 96 359 117 −369 −294 −249 —−16 −7108 −8150 −894 −1115 −701 −1378 * * 274(I) −2091 −1746 −3971 −3840−1676 −3532 −3289 3684 −3581 −659 −693 −3562 −3674 −3445 −3521 −3194−2146 449 −2877 −2493 294 — −149 −500 233 43 −381 399 106 −626 210 −466−720 275 394 45 96 359 117 −369 −294 −249 — −16 −7108 −8150 −894 −1115−701 −1378 * * 275(Q −1627 −2584 −1823 −913 −3248 −2312 −430 −2707 1993−2449 −1710 −969 −2306 3139 1660 −1504 −1407 −2413 −2377 −2126 295 —−149 −500 233 43 −381 399 106 −626 210 −466 −720 275 394 45 96 359 117−369 −294 −249 — −16 −7108 −8150 −894 −1115 −701 −1378 * * 276(K 949−2020 −181 1024 −2347 −1460 −176 −2077 2067 −2031 −1143 996 −1606 264−187 −477 −547 −1653 −2203 −1543 296 — −149 −500 233 43 −381 399 106−626 210 −466 −720 275 394 45 96 359 117 −369 −294 −249 — −16 −7108−8150 −894 −1115 −701 −1378 * * 277(H 1280 −1815 −274 261 −2114 −13921493 −1840 1076 −1818 −916 946 −1489 1230 −102 −316 245 −1427 −2010−1354 297 — −149 −500 233 43 −381 399 106 −626 210 −466 −720 275 394 4596 359 117 −369 −294 −249 — −16 −7108 −8150 −894 −1115 −701 −1378 * *278(A 3438 −1472 −2846 −3040 −3287 −1726 −2735 −2840 −3028 −3257 −2662−2236 −2447 −2798 −2944 −1216 −1387 −2183 −3405 −3320 298 — −149 −500233 43 −381 399 106 −626 210 −466 −720 275 394 45 96 359 117 −369 −294−249 — −16 −7108 −8150 −894 −1115 −701 −1378 * * 279(R −836 −1922 −846−238 −2255 −1752 −261 −1878 494 −1879 −1072 484 −1828 1594 2601 −770−741 369 −2053 −1564 299 — −149 −500 233 43 −381 399 106 −626 210 −466−720 275 394 45 96 359 117 −369 −294 −249 — −16 −7108 −8150 −894 −1115−701 −1378 * * 280(E) −531 −1917 −152 1776 −2240 −1412 −166 −1971 212−1955 −1067 −76 −1565 1351 −287 854 1223 −1553 −2155 −1485 300 — −149−500 233 43 −381 399 106 −626 210 −466 −720 275 394 45 96 359 117 −369−294 −249 — −16 −7108 −8150 −894 −1115 −701 −1378 * * 281(N −756 −22771639 264 −2584 735 −320 −2357 −45 −2301 −1420 1764 −1681 1399 −604 499−725 −1902 −2482 −1746 301 — −149 −500 233 43 −381 399 106 −626 210 −466−720 275 394 45 96 359 117 −369 −294 −249 — −1243 −7108 −811 −894 −1115−701 −1378 * * 282(T) 391 −254 −749 −541 −1519 −523 −582 −1080 −464−1400 −646 −345 −1090 −368 −718 1584 1914 −580 −1775 −1351 302 — −149−500 233 43 −381 399 106 −626 210 −466 −720 275 394 45 96 359 117 −369−294 −249 — −36 −5902 −6944 −894 −1115 −2014 −410 * * 283(N 1419 −678−16 71 −1606 −696 −281 −1227 −86 −1488 −735 2022 −1167 9 −450 17 −79−791 −1790 −1251 303 — −149 −500 233 43 −381 399 106 −626 210 −466 −720275 394 45 96 359 117 −369 −294 −249 — −36 −5902 −6944 −894 −1115 −655−1455 * * 284(N −690 −2252 1313 1338 −2538 −1300 −208 −2319 1491 −2250−1381 1988 −1564 211 −512 −509 −660 −1861 −2424 −1672 304 — −149 −500233 43 −381 399 106 −626 210 −466 −720 275 394 45 96 359 117 −369 −294−249 — −20 −6788 −7830 −894 −1115 −421 −1984 * * 285(D −1304 −3019 26801285 −3255 −1544 −705 −3097 −703 −3006 −2219 1388 1348 −331 −1399 −1044−1321 −2611 −3195 −2320 305 — −149 −500 233 43 −381 399 106 −626 210−466 −720 275 394 45 96 359 117 −369 −294 −249 — −16 −7108 −8150 −894−1115 −701 −1378 * * 286(H −30 439 11 363 −394 −739 699 −414 463 −757501 286 −577 639 165 −23 111 −312 697 −25 306 — −149 −500 233 43 −381399 106 −626 210 −466 −720 275 394 45 96 359 117 −369 −294 −249 — −16−7108 −8150 −894 −1115 −701 −1378 * * 287(M 1003 −593 321 −1362 −615−2007 −849 1868 −1149 −373 2071 −1286 −2064 −949 −1296 −1049 −514 769−1128 −747 307 — −149 −500 233 43 −381 399 106 −626 210 −466 −720 275394 45 96 359 117 −369 −294 −249 — −16 −7108 −8150 −894 −1115 −701−1378 * * 288(M −426 −945 −995 −468 −1082 −1580 1667 −681 −299 −938 2081−605 −1724 −229 −641 445 2054 −498 −1403 −940 308 — −149 −500 233 43−381 399 106 −626 210 −466 −720 275 394 45 96 359 117 −369 −294 −249 —−16 −7108 −8150 −894 −1115 −701 −1378 * * 289(R −1619 −2365 −2075 −1064−2835 −2363 −469 −2305 1823 763 −1488 −1073 −2345 −67 2817 −1563 −1402−2096 −2243 −1997 309 — −149 −500 233 43 −381 399 106 −626 210 −466 −720275 394 45 96 359 117 −369 −294 −249 — −16 −7108 −8150 −894 −1115 −701−1378 * * 290(P) −2931 −2878 −3420 −3706 −4181 −2925 −3468 −4621 −3859−4490 −4165 −3491 4225 −3781 −3695 −3182 −3279 −4087 −3594 −4064 310 —−149 −500 233 43 −381 399 106 −626 210 −466 −720 275 394 45 96 359 117−369 −294 −249 — −16 −7108 −8150 −894 −1115 −701 −1378 * * 291(Q −802−740 −2393 −1814 1799 −2272 −1035 123 −1529 790 401 −1638 −2287 2034−1573 −1335 −740 1456 −1046 −619 311 — −149 −500 233 43 −381 399 106−626 210 −466 −720 275 394 45 96 359 117 −369 −294 −249 — −16 −7108−8150 −894 −1115 −701 −1378 * * 292(W −3500 −2678 −4063 −4226 995 −3934−449 −2563 −3717 −2009 −2016 −2732 −3866 −2798 −3276 −3242 −3394 −26815405 3043 312 — −149 −500 233 43 −381 399 106 −626 210 −466 −720 275 39445 96 359 117 −369 −294 −249 — −16 −7108 −8150 −894 −1115 −701 −1378 * *293(P) −2931 −2878 −3420 −3706 −4181 −2925 −3468 −4621 −3859 −4490 −4165−3491 4225 −3781 −3695 −3182 −3279 −4087 −3594 −4064 313 — −149 −500 23343 −381 399 106 −626 210 −466 −720 275 394 45 96 359 117 −369 −294 −249— −16 −7108 −8150 −894 −1115 −701 −1378 * * 294(M −2406 −2296 −3638−3594 −1525 −3105 −2824 −1047 −3121 −596 5043 −3293 −3425 −3046 −2996−2911 −2552 −1398 −2513 −2207 314 — −149 −500 233 43 −381 399 106 −626210 −466 −720 275 394 45 96 359 117 −369 −294 −249 — −16 −7108 −8150−894 −1115 −701 −1378 * * 295(I) −2034 −1595 −4395 −3950 −974 −4099−3249 3261 −3681 1202 174 −3748 −3784 −3212 −3556 −3388 −1988 627 −2497−2285 315 — −149 −500 233 43 −381 399 106 −626 210 −466 −720 275 394 4596 359 117 −369 −294 −249 — −16 −7108 −8150 −894 −1115 −701 −1378 * *296(I) −1757 −1299 −4333 −3971 −1766 −4057 −3755 2831 −3844 −614 −541−3733 −3880 −3700 −3920 −3375 −1749 2665 −3275 −2830 316 — −149 −500 23343 −381 399 106 −626 210 −466 −720 275 394 45 96 359 117 −369 −294 −249— −16 −7108 −8150 −894 −1115 −701 −1378 * * 297(F) −2590 −2117 −4458−4084 3096 −4144 −1957 −191 −3757 2203 405 −3544 −3752 −2887 −3401 −3410−2485 −812 −1135 −337 317 — −149 −500 233 43 −381 399 106 −626 210 −466−720 275 394 45 96 359 117 −369 −294 −249 — −16 −7108 −8150 −894 −1115−701 −1378 * * 298(R −2957 −3022 −3318 −2735 −3796 −2998 −1968 −3912−846 −3631 −3157 −2611 −3280 −1724 4056 −3026 −2913 −3650 −3096 −3185318 — −149 −500 233 43 −381 399 106 −626 210 −466 −720 275 394 45 96 359117 −369 −294 −249 — −16 −7108 −8150 −894 −1115 −701 −1378 * * 299(T)2050 −905 −2305 −2099 −2720 −1206 −1895 −2371 −1974 −2648 −1815 −1479−1888 −1753 −2118 1016 2546 −1624 −2968 −2665 319 — −149 −500 233 43−381 399 106 −626 210 −466 −720 275 394 45 96 359 117 −369 −294 −249 —−16 −7108 −8150 −894 −1115 −701 −1378 * * 300(P) −2931 −2878 −3420 −3706−4181 −2925 −3468 −4621 −3859 −4490 −4165 −3491 4225 −3781 −3695 −3182−3279 −4087 −3594 −4064 320 — −149 −500 233 43 −381 399 106 −626 210−466 −720 275 394 45 96 359 117 −369 −294 −249 — −16 −7108 −8150 −894−1115 −701 −1378 * * 301(K −2620 −2961 −2461 −2046 −3743 −2791 −1570−3603 3784 −3387 −2839 −2048 −3039 −1260 −465 −2604 −2536 −3331 −3001−2988 321 — −149 −500 233 43 −381 399 106 −626 210 −466 −720 275 394 4596 359 117 −369 −294 −249 — −16 −7108 −8150 −894 −1115 −701 −1378 * *302(G −2594 −2690 −3304 −3623 −4328 3747 −3462 −4761 −3953 −4671 −4212−3320 −3352 −3748 −3779 −2839 −2981 −4004 −3668 −4222 322 — −149 −500233 43 −381 399 106 −626 210 −466 −720 275 394 45 96 359 117 −369 −294−249 — −16 −7108 −8150 −894 −1115 −701 −1378 * * 303(W −4114 −3274 −4214−4453 −1722 −3496 −2681 −4109 −4149 −3619 −3615 −4044 −3885 −4032 −3816−4355 −4248 −4133 6191 −1329 323 — −149 −500 233 43 −381 399 106 −626210 −466 −720 275 394 45 96 359 117 −369 −294 −249 — −16 −7108 −8150−894 −1115 −701 −1378 * * 304(T) −353 −974 −2215 −2202 −2896 −1238 −2053−2560 −2141 −2867 −2052 −1547 −1951 −1940 −2229 1380 3291 −1759 −3143−2840 324 — −149 −500 233 43 −381 399 106 −626 210 −466 −720 275 394 4596 359 117 −369 −294 −249 — −16 −7108 −8150 −894 −1115 −701 −1378 * *305(C −845 3595 −3279 −3420 −3342 3140 −2815 −3103 −3232 −3426 −2671−2300 −2379 −2934 −3057 −1107 −1278 −2270 −3401 −3393 325 — −149 −500233 43 −381 399 106 −626 210 −466 −720 275 394 45 96 359 117 −369 −294−249 — −16 −7108 −8150 −894 −1115 −701 −1378 * * 306(P) −2931 −2878−3420 −3706 −4181 −2925 −3468 −4621 −3859 −4490 −4165 −3491 4225 −3781−3695 −3182 −3279 −4087 −3594 −4064 326 — −149 −500 233 43 −381 399 106−626 210 −466 −720 275 394 45 96 359 117 −369 −294 −249 — −16 −7108−8150 −894 −1115 −701 −1378 * * 307(K −2620 −2961 −2461 −2046 −3743−2791 −1570 −3603 3784 −3387 −2839 −2048 −3039 −1260 −465 −2604 −2536−3331 −3001 −2988 327 — −149 −500 233 43 −381 399 106 −626 210 −466 −720275 394 45 96 359 117 −369 −294 −249 — −16 −7108 −8150 −894 −1115 −701−1378 * * 308(M −402 −813 −1034 898 582 −1639 −381 −420 −330 −698 1526−611 −1715 −218 −668 337 1310 −272 −1195 1104 328 — −149 −500 234 43−381 399 106 −626 210 −466 −720 275 394 45 96 359 117 −369 −294 −249 —−176 −3166 −8150 −310 −2369 −701 −1378 * * 309(W −1600 −1315 −3759 −3181−295 −3243 −1874 1788 −2803 1756 538 −2802 −3074 −2285 −2600 −2379 −1521−139 4106 −936 330 — −149 −500 233 43 −381 399 106 −626 210 −466 −720275 394 45 96 359 117 −369 −294 −249 — −16 −7108 −8150 −894 −1115 −701−1378 * * 310(D −1718 −3250 3403 −27 −3066 −1736 2667 −3486 −1211 −3381−2732 −400 −2240 −752 −1917 −1439 −1784 −3023 −3204 −2299 331 — −149−500 233 43 −381 399 106 −626 210 −466 −720 275 394 45 96 359 117 −369−294 −249 — −16 −7108 −8150 −894 −1115 −701 −1378 * * 311(G −1708 −26671499 −644 −3784 3218 −1636 −3799 −1910 −3782 −3127 −941 −2466 −1384−2554 −1618 −1929 −3151 −3633 −3136 332 — −149 −500 233 43 −381 399 106−626 210 −466 −720 275 394 45 96 359 117 −369 −294 −249 — −16 −7108−8150 −894 −1115 −701 −1378 * * 312(K −708 −2195 956 221 −2514 −1474−242 −2264 2240 −2194 −1308 1084 −1658 1697 −314 −557 −656 −1821 −2352−1662 333 — −149 −500 233 43 −381 399 106 −626 210 −466 −720 275 394 4596 359 117 −369 −294 −249 — −16 −7108 −8150 −894 −1115 −701 −1378 * *313(P) −762 −1504 −940 −454 1424 −1749 −441 −1317 1946 −1439 −747 −6291988 −176 −300 −813 −723 −1105 −1603 −967 334 — −149 −500 233 43 −381399 106 −626 210 −466 −720 275 394 45 96 359 117 −369 −294 −249 — −16−7108 −8150 −894 −1115 −701 −1378 * * 314(I) −1232 −1121 −3291 −2953−1431 −2753 −2412 3122 −2652 −599 −404 −2590 −2982 −2506 −2674 −20201485 773 −2421 −2034 335 — −149 −500 233 43 −381 399 106 −626 210 −466−720 275 394 45 96 359 117 −369 −294 −249 — −16 −7108 −8150 −894 −1115−701 −1378 * * 315(E) −2641 −3308 −896 3732 −3966 −2458 −2043 −4105−2128 −4016 −3555 −1531 −2959 −1842 −2560 −2479 −2750 −3722 −3563 −3385336 — −149 −500 233 43 −381 399 106 −626 210 −466 −720 275 394 45 96 359117 −369 −294 −249 — −16 −7108 −8150 −894 −1115 −701 −1378 * * 316(G)−1046 −1820 −755 −1003 −3341 2933 −1683 −3325 −1756 −3410 −2651 2259−2235 −1456 −2142 −1125 −1359 −2537 −3369 −2897 337 — −149 −500 233 43−381 399 106 −626 210 −466 −720 275 394 45 96 359 117 −369 −294 −249 —−16 −7108 −8150 −894 −1115 −701 −1378 * * 317(S) −897 −1462 −2333 −2543−3185 −1640 −2474 −3294 −2686 −3497 −2780 −1973 −2360 −2483 −2703 3465−1316 −2413 −3310 −3025 338 — −149 −500 233 43 −381 399 106 −626 210−466 −720 275 394 45 96 359 117 −369 −294 −249 — −16 −7108 −8150 −894−1115 −701 −1378 * * 318(W −3425 −2618 −4155 −4330 3859 −3949 −484 −2303−3894 −1728 −1759 −2779 −3865 −2847 −3389 −3247 −3323 −2490 3919 1426339 — −149 −500 233 43 −381 399 106 −626 210 −466 −720 275 394 45 96 359117 −369 −294 −249 — −16 −7108 −8150 −894 −1115 −701 −1378 * * 319(R−1940 −2623 −2163 −1317 −2718 −2498 2633 −2821 557 −2576 −1920 −1294−2549 −305 3406 −1859 −1734 −2575 −2279 −1885 340 — −149 −500 233 43−381 399 106 −626 210 −466 −720 275 394 45 96 359 117 −369 −294 −249 —−16 −7108 −8150 −894 −1115 −701 −1378 * * 320(A 2865 −932 −2456 −2481−3066 −1198 −2239 −2763 −2443 −3058 −2203 −1637 −1941 −2156 −2474 1737−732 −1840 −3307 −3058 341 — −149 −500 233 43 −381 399 106 −626 210 −466−720 275 394 45 96 359 117 −369 −294 −249 — −16 −7108 −8150 −894 −1115−701 −1378 * * 321(H −3205 −3079 −2723 −2890 −2110 −3046 5295 −4135−2617 −3813 −3561 −2886 −3482 −2833 −2620 −3291 −3356 −3895 −2397 −1681342 — −149 −500 233 43 −381 399 106 −626 210 −466 −720 275 394 45 96 359117 −369 −294 −249 — −16 −7108 −8150 −894 −1115 −701 −1378 * * 322(Q−2562 −2904 −1886 −1971 −3251 −2661 −2079 −3690 −1565 −3469 −3081 −2107−3091 4371 −1665 −2585 −2674 −3411 −3077 −2821 343 — −149 −500 233 43−381 399 106 −626 210 −466 −720 275 394 45 96 359 117 −369 −294 −249 —−16 −7108 −8150 −894 −1115 −701 −1378 * * 323(I) −1757 −1300 −4333 −3971−1764 −4057 −3754 2871 −3843 −611 −539 −3733 −3880 −3699 −3919 −3375−1749 2625 −3273 −2829 344 — −149 −500 233 43 −381 399 106 −626 210 −466−720 275 394 45 96 359 117 −369 −294 −249 — −16 −7108 −8150 −894 −1115−701 −1378 * * 324(P) −2931 −2878 −3420 −3706 −4181 −2925 −3468 −4621−3859 −4490 −4165 −3491 4225 −3781 −3695 −3182 −3279 −4087 −3594 −4064345 — −149 −500 233 43 −381 399 106 −626 210 −466 −720 275 394 45 96 359117 −369 −294 −249 — −16 −7108 −8150 −894 −1115 −701 −1378 * * 325(I)−1899 −1466 −4358 −3871 −1002 −3993 −3149 2479 −3652 1948 170 −3634−3690 −3153 −3516 −3233 −1847 1460 −2466 −2295 346 — −149 −500 233 43−381 399 106 −626 210 −466 −720 275 394 45 96 359 117 −369 −294 −249 —−16 −7108 −8150 −894 −1115 −701 −1378 * * 326(P) 1615 −1136 −2222 −2310−3082 −1373 −2227 −2731 −2358 −3036 −2272 −1689 3445 −2139 −2424 −761−938 −1937 −3279 −3042 347 — −149 −500 233 43 −381 399 106 −626 210 −466−720 275 394 45 96 359 117 −369 −294 −249 — −16 −7108 −8150 −894 −1115−701 −1378 * * 327(V 776 −978 −1248 −821 −1609 −1418 −840 −1138 −733−1453 −710 1478 −1781 −614 −1074 1249 −508 1777 −1905 −1460 348 — −149−500 233 43 −381 399 106 −626 210 −466 −720 275 394 45 96 359 117 −369−294 −249 — −16 −7108 −8150 −894 −1115 −701 −1378 * * 328(D 1973 −17932321 −222 −2801 −1401 −864 −2543 −758 −2614 −1785 −457 −1858 −510 −1294684 −896 −1978 −2851 −2198 349 — −149 −500 233 43 −381 399 106 −626 210−466 −720 275 394 45 96 359 117 −369 −294 −249 — −16 −7108 −8150 −894−1115 −701 −1378 * * 329(Q −1008 −2231 −986 −310 −2701 −1861 −258 −23151642 −2173 −1344 −511 −1911 2494 1827 403 −883 −1946 −2224 −1767 350 —−149 −500 233 43 −381 399 106 −626 210 −466 −720 275 394 45 96 359 117−369 −294 −249 — −16 −7108 −8150 −894 −1115 −701 −1378 * * 330(D −1037−2659 2253 1117 −2928 −1504 −509 −2731 1324 −2651 −1807 1958 −1830 −106−940 −826 −1023 −2261 −2827 −2032 351 — −149 −500 233 43 −381 399 106−626 210 −466 −720 275 394 45 96 359 117 −369 −294 −249 — −16 −7108−8150 −894 −1115 −701 −1378 * * 331(H −935 −2308 2421 146 −2574 −15082726 −2388 −331 −2395 −1577 −187 −1822 −135 −890 −787 1407 −1976 −2588−1852 352 — −149 −500 233 43 −381 399 106 −626 210 −466 −720 275 394 4596 359 117 −369 −294 −249 — −16 −7108 −8150 −894 −1115 −701 −1378 * *332(M −650 −1996 1349 1466 −2242 −1448 −264 −1958 34 −1982 2809 −101 597150 −493 −533 −608 −1580 −2227 −1552 353 — −149 −500 233 43 −381 399 106−626 210 −466 −720 275 394 45 96 359 117 −369 −294 −249 — −16 −7108−8150 −894 −1115 −701 −1378 * * 333(E) 1263 −2196 −74 2930 −2933 −1571−907 −2588 −778 −2712 −1962 −469 −2014 −562 −1290 −991 −1179 −2137 −2954−2290 354 — −149 −500 233 43 −381 399 106 −626 210 −466 −720 275 394 4596 359 117 −369 −294 −249 — −16 −7108 −8150 −894 −1115 −701 −1378 * *334(H −1082 −2079 −440 1291 −845 −1821 3880 −1961 −281 −1944 −1264 −509−2017 −267 −666 −989 −1031 −1699 −1298 1603 355 — −149 −500 233 43 −381399 106 −626 210 −466 −720 275 394 45 96 359 117 −369 −294 −249 — −16−7108 −8150 −894 −1115 −701 −1378 * * 335(F) 1005 −431 −2207 −1610 1664−1966 −799 1077 332 809 427 −1386 −2016 −1061 −1337 −1023 −432 229 −879−519 356 — −149 −500 233 43 −381 399 106 −626 210 −466 −720 275 394 4596 359 117 −369 −294 −249 — −16 −7108 −8150 −894 −1115 −701 −1378 * *336(H −30 439 11 363 −394 −739 699 −414 463 −757 501 286 −577 639 165−23 111 −312 697 −25 357 — −149 −500 233 43 −381 399 106 −626 210 −466−720 275 394 45 96 359 117 −369 −294 −249 — −16 −7108 −8150 −894 −1115−701 −1378 * * 337(D −996 −2602 2234 1640 −2872 −1493 −484 −2671 −308−2598 −1748 −104 783 1779 −913 −792 −980 −2205 −2778 −1990 358 — −149−500 233 43 −381 399 106 −626 210 −466 −720 275 394 45 96 359 117 −369−294 −249 — −16 −7108 −8150 −894 −1115 −701 −1378 * * 338(A 1659 −679−1813 −1259 −745 −1962 −855 1055 −1039 −483 101 −1222 −2054 1021 −1227−1014 −543 1478 −1248 −857 359 — −149 −500 233 43 −381 399 106 −626 210−466 −720 275 394 45 96 359 117 −369 −294 −249 — −16 −7108 −8150 −894−1115 −701 −1378 * * 339(L) −2871 −2457 −4231 −4103 −1033 −3803 −3165−541 −3734 3130 −31 −3935 −3797 −3286 −3484 −3713 −2869 −1136 −2394−2220 360 — −149 −500 233 43 −381 399 106 −626 210 −466 −720 275 394 4596 359 117 −369 −294 −249 — −16 −7108 −8150 −894 −1115 −701 −1378 * *340(V −891 −1677 −1034 −464 −1912 −1849 −400 −1350 1652 −1575 −859 −635−1938 1706 124 −916 −803 2029 −1916 −1472 361 — −149 −500 233 43 −381399 106 −626 210 −466 −720 275 394 45 96 359 117 −369 −294 −249 — −16−7108 −8150 −894 −1115 −701 −1378 * * 341(D −869 −2445 2202 1077 −2729120 −389 −2516 1310 −2445 −1574 1245 −1739 29 −730 −684 −841 −2053 −2620−1858 362 — −149 −500 233 43 −381 399 106 −626 210 −466 −720 275 394 4596 359 117 −369 −294 −249 — −16 −7108 −8150 −894 −1115 −701 −1378 * *342(W −4114 −3274 −4214 −4453 −1722 −3496 −2681 −4109 −4149 −3619 −3615−4044 −3885 −4032 −3816 −4355 −4248 −4133 6191 −1329 363 — −149 −500 23343 −381 399 106 −626 210 −466 −720 275 394 45 96 359 117 −369 −294 −249— −16 −7108 −8150 −894 −1115 −701 −1378 * * 343(L) −2642 −2168 −4788−4235 −465 −4513 −3241 96 −3878 2891 2122 −4166 −3888 −3023 −3544 −3807−2521 −607 −2140 −2183 364 — −149 −500 233 43 −381 399 106 −626 210 −466−720 275 394 45 96 359 117 −369 −294 −249 — −16 −7108 −8150 −894 −1115−701 −1378 * * 344(E) −588 −2030 −204 1763 −2360 −1459 −147 −2094 1522−2032 −1135 −95 −1592 1372 −129 847 −526 −1661 −2190 −1529 365 — −149−500 233 43 −381 399 106 −626 210 −466 −720 275 394 45 96 359 117 −369−294 −249 — −16 −7108 −8150 −894 −1115 −701 −1378 * * 345(S) −897 −1462−2333 −2543 −3185 −1640 −2474 −3294 −2686 −3497 −2780 −1973 −2360 −2483−2703 3465 −1316 −2413 −3310 −3025 366 — −149 −500 233 43 −381 399 106−626 210 −466 −720 275 394 45 96 359 117 −369 −294 −249 — −16 −7108−8150 −894 −1115 −701 −1378 * * 346(Y −3482 −2868 −3701 −3919 238 −3552−1112 −3000 −3638 −2516 −2526 −3027 −3772 −3101 −3341 −3418 −3527 −3071−441 4711 367 — −149 −500 233 43 −381 399 106 −626 210 −466 −720 275 39445 96 359 117 −369 −294 −249 — −16 −7108 −8150 −894 −1115 −701 −1378 * *347(K −1779 −2672 −1588 −963 −3316 −2329 −561 −2833 3294 −2578 −1879−1030 −2399 1424 589 −1653 −1579 −2550 −2489 −2237 368 — −149 −500 23343 −381 399 106 −626 210 −466 −720 275 394 45 96 359 117 −369 −294 −249— −16 −7108 −8150 −894 −1115 −701 −1378 * * 348(P) −2931 −2878 −3420−3706 −4181 −2925 −3468 −4621 −3859 −4490 −4165 −3491 4225 −3781 −3695−3182 −3279 −4087 −3594 −4064 369 — −149 −500 233 43 −381 399 106 −626210 −466 −720 275 394 45 96 359 117 −369 −294 −249 — −16 −7108 −8150−894 −1115 −701 −1378 * * 349(E) −1283 −2980 2293 2465 −3222 −1551 −680−3054 846 −2961 −2167 −151 −1956 −302 −1278 −1029 −1292 −2574 −3140−2287 370 — −149 −500 233 43 −381 399 106 −626 210 −466 −720 275 394 4596 359 117 −369 −294 −249 — −16 −7108 −8150 −894 −1115 −701 −1378 * *350(E) −2641 −3308 −896 3732 −3966 −2458 −2043 −4105 −2128 −4016 −3555−1531 −2959 −1842 −2560 −2479 −2750 −3722 −3563 −3385 371 — −149 −500233 43 −381 399 106 −626 210 −466 −720 275 394 45 96 359 117 −369 −294−249 — −16 −7108 −8150 −894 −1115 −701 −1378 * * 351(L) −2871 −2457−4231 −4103 −1033 −3803 −3165 −541 −3734 3130 −31 −3935 −3797 −3286−3484 −3713 −2869 −1136 −2394 −2220 372 — −149 −500 233 43 −381 399 106−626 210 −466 −720 275 394 45 96 359 117 −369 −294 −249 — −16 −7108−8150 −894 −1115 −701 −1378 * * 352(F) −3342 −2776 −4026 −4232 4354−3545 −1431 −2315 −4038 −1801 −1900 −3299 −3780 −3350 −3645 −3490 −3420−2566 −739 349 373 — −149 −500 233 43 −381 399 106 −626 210 −466 −720275 394 45 96 359 117 −369 −294 −249 — −16 −7108 −8150 −894 −1115 −701−1378 * * 353(D −1170 −2662 2768 152 −3076 −1523 −716 −2882 −677 −2851−2058 1883 −1940 −347 −1326 −973 1251 −2402 −3056 −2245 374 — −149 −500233 43 −381 399 106 −626 210 −466 −720 275 394 45 96 359 117 −369 −294−249 — −16 −7108 −8150 −894 −1115 −701 −1378 * * 354(E) 1031 −2152 −912416 −2507 −1517 −346 −2220 982 −2201 −1350 −188 −1736 71 −388 −657 −752−1810 −2390 −1731 375 — −149 −500 233 43 −381 399 106 −626 210 −466 −720275 394 45 96 359 117 −369 −294 −249 — −16 −7108 −8150 −894 −1115 −701−1378 * * 355(N −1247 −2802 2354 164 −3217 −1531 −760 −3060 −767 −2997−2213 2573 −1971 −395 −1447 1055 −1298 −2553 −3188 −2339 376 — −149 −500233 43 −381 399 106 −626 210 −466 −720 275 394 45 96 359 117 −369 −294−249 — −16 −7108 −8150 −894 −1115 −701 −1378 * * 356(G −2594 −2690 −3304−3623 −4328 3747 −3462 −4761 −3953 −4671 −4212 −3320 −3352 −3748 −3779−2839 −2981 −4004 −3668 −4222 377 — −149 −500 233 43 −381 399 106 −626210 −466 −720 275 394 45 96 359 117 −369 −294 −249 — −16 −7108 −8150−894 −1115 −701 −1378 * * 357(H 969 −1896 1173 279 −2199 −1387 1573−1938 276 −1912 −1011 −34 −1518 1339 −236 939 −421 −1513 −2105 −1426 378— −149 −500 233 43 −381 399 106 −626 210 −466 −720 275 394 45 96 359 117−369 −294 −249 — −16 −7108 −8150 −894 −1115 −701 −1378 * * 358(V −1097−861 −3273 −2702 −715 −2790 −1749 1319 −2390 1604 246 −2365 510 −2047−2299 −1909 −1047 2041 −1564 −1253 379 — −149 −500 233 43 −381 399 106−626 210 −466 −720 275 394 45 96 359 117 −369 −294 −249 — −16 −7108−8150 −894 −1115 −701 −1378 * * 359(K −627 −934 −1396 −826 −1049 −1906−680 1291 2041 −745 −142 −930 −1983 −512 −793 −921 762 912 −1475 −1045380 — −149 −500 233 43 −381 399 106 −626 210 −466 −720 275 394 45 96 359117 −369 −294 −249 — −16 −7108 −8150 −894 −1115 −701 −1378 * * 360(D 417−2242 2268 951 −2534 −1439 −289 −2301 2 −2249 −1365 −64 475 1392 −551−566 −688 −1853 −2431 −1702 381 — −149 −500 233 43 −381 399 106 −626 210−466 −720 275 394 45 96 359 117 −369 −294 −249 — −16 −7108 −8150 −894−1115 −701 −1378 * * 361(D −756 −2213 2042 1784 −2484 −1455 −327 −2233−59 −287 −1351 −90 −1688 90 −612 609 −722 −1813 −2423 −1705 382 — −149−500 233 43 −381 399 106 −626 210 −466 −720 275 394 45 96 359 117 −369−294 −249 — −16 −7108 −8150 −894 −1115 −701 −1378 * * 362(I) −1758 −1302−4331 −3969 −1754 −4053 −3745 3003 −3839 −600 −530 −3730 −3876 −3691−3912 −3370 −1751 2469 −3262 −2822 383 — −149 −500 233 43 −381 399 106−626 210 −466 −720 275 394 45 96 359 117 −369 −294 −249 — −16 −7108−8150 −894 −1115 −701 −1378 * * 363(K −489 −1736 −399 869 −1996 −1468−108 −1679 1463 680 −849 −140 −1560 1326 −65 −410 492 −1326 −1942 −1336384 — −149 −500 233 43 −381 399 106 −626 210 −466 −720 275 394 45 96 359117 −369 −294 −249 — −16 −7108 −8150 −894 −1115 −701 −1378 * * 364(E)1607 −1738 −268 2001 −2459 −1405 −567 −2171 −308 −2231 −1384 −339 −1737−179 −802 1027 −695 −1699 −2473 −1839 385 — −149 −500 233 43 −381 399106 −626 210 −466 −720 275 394 45 96 359 117 −369 −294 −249 — −16 −7108−8150 −894 −1115 −701 −1378 * * 365(I) −521 −410 −2443 −1845 1682 −2040−909 1831 −1536 −217 389 581 −2091 −1245 −1495 −1112 673 1143 −913 −551386 — −149 −500 233 43 −381 399 106 −626 210 −466 −720 275 394 45 96 359117 −369 −294 −249 — −16 −7108 −8150 −894 −1115 −701 −1378 * * 366(M−1028 −781 −3313 −2728 −655 −2725 −1667 2105 −2396 791 2636 −2332 −2694−2027 −2260 −1840 662 1307 −1459 −1146 387 — −149 −500 233 43 −381 399106 −626 210 −466 −720 275 394 45 96 359 117 −369 −294 −249 — −16 −7108−8150 −894 −1115 −701 −1378 * * 367(P) −2931 −2878 −3420 −3706 −4181−2925 −3468 −4621 −3859 −4490 −4165 −3491 4225 −3781 −3695 −3182 −3279−4087 −3594 −4064 388 — −149 −500 233 43 −381 399 106 −626 210 −466 −720275 394 45 96 359 117 −369 −294 −249 — −16 −7108 −8150 −894 −1115 −701−1378 * * 368(K −420 −1711 −319 889 −1985 −1406 −81 −1683 1799 −1711−835 −80 −1506 351 −148 802 593 66 −1944 −1311 389 — −149 −500 233 43−381 399 106 −626 210 −466 −720 275 394 45 96 359 117 −369 −294 −249 —−16 −7108 −8150 −894 −1115 −701 −1378 * * 369(G −1210 −2695 1728 114−3097 2436 −713 −2899 1005 −2848 −2055 −236 −1965 −340 −1178 −1009 −1238−2429 −3026 −2250 390 — −149 −500 233 43 −381 399 106 −626 210 −466 −720275 394 45 96 359 117 −369 −294 −249 — −16 −7108 −8150 −894 −1115 −701−1378 * * 370(D −1173 −2847 2185 2156 −3091 −1523 1843 −2917 −527 −2832−2014 1280 −1899 −221 −1180 −937 −1174 −2440 −3014 −2176 391 — −149 −500233 43 −381 399 106 −626 210 −466 −720 275 394 45 96 359 117 −369 −294−249 — −16 −7108 −8150 −894 −1115 −701 −1378 * * 371(K −733 −1639 −900−275 −1870 −1727 −272 −1476 1449 1052 −793 −476 −1798 105 1100 1022 −645−1222 −1849 −1373 392 — −149 −500 233 43 −381 399 106 −626 210 −466 −720275 394 45 96 359 117 −369 −294 −249 — −16 −7108 −8150 −894 −1115 −701−1378 * * 372(R −2124 −2788 −2710 −1449 −3624 −2637 −576 −2974 1929−2640 −1977 −1344 −2596 −161 3417 −2010 −1819 −2745 −2479 −2379 393 —−149 −500 233 43 −381 399 106 −626 210 −466 −720 275 394 45 96 359 117−369 −294 −249 — −16 −7108 −8150 −894 −1115 −701 −1378 * * 373(M −2186−1770 −4484 −3908 −547 −4083 −2924 1892 −3619 1562 3822 −3715 −3642−2876 −3343 −3290 −2088 −106 −2072 −2052 394 — −149 −500 233 43 −381 399106 −626 210 −466 −720 275 394 45 96 359 117 −369 −294 −249 — −16 −7108−8150 −894 −1115 −701 −1378 * * 374(A 2525 −1036 −2401 −2529 −3239 2375−2366 −2958 −2629 −3244 −2393 −1719 −2028 −2303 −2639 −657 −852 −1993−3425 −3237 395 — −149 −500 233 43 −381 399 106 −626 210 −466 −720 275394 45 96 359 117 −369 −294 −249 — −16 −7108 −8150 −894 −1115 −701−1378 * * 375(M 1980 −959 −1279 −892 −1385 −1524 −842 −905 −763 −12112928 1065 −1852 −673 −1053 −675 −559 −683 −1743 −1304 396 — −149 −500233 43 −381 399 106 −626 210 −466 −720 275 394 45 96 359 117 −369 −294−249 — −16 −7108 −8150 −894 −1115 −701 −1378 * * 376(N −1426 −2353 −948−735 −2920 −1991 −796 −2769 68 −2666 −1942 3441 −2268 −432 1742 −1361−1415 −2383 −2592 −2147 397 — −149 −500 233 43 −381 399 106 −626 210−466 −720 275 394 45 96 359 117 −369 −294 −249 — −16 −7108 −8150 −894−1115 −701 −1378 * * 377(P) −566 −1202 −1850 −1997 −3117 −1371 −2101−2989 −2185 −3198 −2391 −1549 3625 −1982 −2305 1013 −967 −2094 −3288−2963 398 — −149 −500 233 43 −381 399 106 −626 210 −466 −720 275 394 4596 359 117 −369 −294 −249 — −276 −7108 −2582 −894 −1115 −701 −1378 * *378(I) −820 −759 −2281 −1810 −939 −2345 −1389 2404 −1595 −425 −18 1689−2430 −1447 −1742 −1465 −804 1594 −1641 −1225 399 — −149 −500 233 43−381 399 106 −626 210 −466 −720 275 394 45 96 359 117 −369 −294 −249 —−19 −6850 −7893 −894 −1115 −1215 −813 * * 379(T) 1785 −732 −2107 −1994−2428 −1065 −1767 −1811 −1860 −2282 −1548 −1351 −1750 −1665 −1956 −3902954 −1225 −2740 −2439 400 — −149 −500 233 43 −381 399 106 −626 210 −466−720 275 394 45 96 359 117 −369 −294 −249 — −19 −6850 −7893 −894 −1115−453 −1893 * * 380(N −1558 −3098 310 1592 −3431 −1657 −945 −3340 −959−3271 −2572 3495 −2146 −611 −1578 −1301 −1621 −2860 −3383 −2547 401 —−149 −500 233 43 −381 399 106 −626 210 −466 −720 275 394 45 96 359 117−369 −294 −249 — −16 −7108 −8150 −894 −1115 −701 −1378 * * 381(G 2030−1051 −2376 −2525 −3268 2820 −2382 −2992 −2652 −3277 −2428 −1726 −2039−2322 −2659 −672 −869 −2018 −3447 −3263 402 — −149 −500 233 43 −381 399106 −626 210 −466 −720 275 394 45 96 359 117 −369 −294 −249 — −16 −7108−8150 −894 −1115 −701 −1378 * * 382(G −1587 −1953 −2017 −2080 −898 3122−1483 −2565 −2178 −2576 −2101 −1908 −2727 −2015 −2307 −1743 −1817 −2251−1457 2463 403 — −149 −500 233 43 −381 399 106 −626 210 −466 −720 275394 45 96 359 117 −369 −294 −249 — −195 −7108 −3069 −894 −1115 −701−1378 * * 383(K −585 −1070 −1140 −510 −1174 −1742 −358 751 1799 −916−239 −641 −1802 −103 873 −754 −507 1342 −1431 −1005 404 — −149 −500 23343 −381 399 106 −626 210 −466 −720 275 394 45 96 359 117 −369 −294 −249— −18 −6931 −7973 −894 −1115 −505 −1760 * * 384(I) −732 −1273 1962 −516−1501 −1754 −770 1970 −673 −1163 −572 −718 −1976 −522 −1082 −902 1162−263 −1908 −1404 405 — −149 −500 233 43 −381 399 106 −626 210 −466 −720275 394 45 96 359 117 −369 −294 −249 — −16 −7108 −8150 −894 −1115 −701−1378 * * 385(H −542 −1652 −558 18 −1880 −1542 2080 339 360 −1605 −778−241 1147 1217 1461 −492 −468 −1229 −1864 −1303 406 — −149 −500 233 43−381 399 106 −626 210 −466 −720 275 394 45 96 359 117 −369 −294 −249 —−16 −7108 −8150 −894 −1115 −701 −1378 * * 386(K −682 −1971 −580 740−2315 −1607 −158 −1989 2284 162 −1077 529 −1686 280 734 −578 −595 −1611−2087 −1523 407 — −149 −500 233 43 −381 399 106 −626 210 −466 −720 275394 45 96 359 117 −369 −294 −249 — −16 −7108 −8150 −894 −1115 −701−1378 * * 387(H −30 439 11 363 −394 −739 699 −414 463 −757 501 286 −577639 165 −23 111 −312 697 −25 408 — −149 −500 233 43 −381 399 106 −626210 −466 −720 275 394 45 96 359 117 −369 −294 −249 — −16 −7108 −8150−894 −1115 −701 −1378 * * 388(P) 415 −2181 1668 189 −2543 −1458 −400−2293 −146 −2281 −1425 −138 2240 1274 −694 −643 −769 −1860 −2492 −1780409 — −149 −500 233 43 −381 399 106 −626 210 −466 −720 275 394 45 96 359117 −369 −294 −249 — −16 −7108 −8150 −894 −1115 −701 −1378 * * 389(L)−1646 −1694 −2904 −2680 −1050 −2701 −2138 −547 −2336 2673 −123 −24791513 −2198 −2336 −2107 −1735 −860 −2077 −1777 410 — −149 −500 233 43−381 399 106 −626 210 −466 −720 275 394 45 96 359 117 −369 −294 −249 —−16 −7108 −8150 −894 −1115 −701 −1378 * * 390(D −430 −1571 1536 153−1777 −1435 −129 307 1131 −1533 −700 889 −1538 275 −255 −380 −371 598−1838 −1235 411 — −149 −500 233 43 −381 399 106 −626 210 −466 −720 275394 45 96 359 117 −369 −294 −249 — −16 −7108 −8150 −894 −1115 −701−1378 * * 391(L) −2871 −2457 −4231 −4103 −1033 −3803 −3165 −541 −37343130 −31 −3935 −3797 −3286 −3484 −3713 −2869 −1136 −2394 −2220 412 —−149 −500 233 43 −381 399 106 −626 210 −466 −720 275 394 45 96 359 117−369 −294 −249 — −16 −7108 −8150 −894 −1115 −701 −1378 * * 392(P) −2931−2878 −3420 −3706 −4181 −2925 −3468 −4621 −3859 −4490 −4165 −3491 4225−3781 −3695 −3182 −3279 −4087 −3594 −4064 413 — −149 −500 233 43 −381399 106 −626 210 −466 −720 275 394 45 96 359 117 −369 −294 −249 — −16−7108 −8150 −894 −1115 −701 −1378 * * 393(D −123 −3021 2652 1083 −3262−1545 −715 −3102 −722 −3016 −2232 2288 −1970 −344 −1422 −1053 −1333−2618 −3208 −2331 414 — −149 −500 233 43 −381 399 106 −626 210 −466 −720275 394 45 96 359 117 −369 −294 −249 — −16 −7108 −8150 −894 −1115 −701−1378 * * 394(W −1183 −940 −3255 −2753 1534 −2632 −772 1086 −2365 113271 −2086 −2628 −1856 −2132 −1737 −1115 −336 3856 1849 415 — −149 −500233 43 −381 399 106 −626 210 −466 −720 275 394 45 96 359 117 −369 −294−249 — −16 −7108 −8150 −894 −1115 −701 −1378 * * 395(R −1025 −2540 17751142 −2847 −1561 −472 −2610 −136 −2532 −1695 −183 −1846 −64 2638 −837−993 −2170 −2686 −1970 416 — −149 −500 233 43 −381 399 106 −626 210 −466−720 275 394 45 96 359 117 −369 −294 −249 — −16 −7108 −8150 −894 −1115−701 −1378 * * 396(D −1284 −2963 2433 216 −3207 −1549 −693 −3050 −653−2963 −2174 2058 −1961 2341 −1315 −1034 −1299 −2571 −3142 −2286 417 —−149 −500 233 43 −381 399 106 −626 210 −466 −720 275 394 45 96 359 117−369 −294 −249 — −16 −7108 −8150 −894 −1115 −701 −1378 * * 397(Y −3621−2707 −4176 −4424 2970 −4050 −394 −2539 −4003 −1942 −1987 −2749 −3933−2855 −3451 −3299 −3499 −2690 349 4083 418 — −149 −500 233 43 −381 399106 −626 210 −466 −720 275 394 45 96 359 117 −369 −294 −249 — −16 −7108−8150 −894 −1115 −701 −1378 * * 398(C 1443 2403 −1117 1144 −997 −1629−520 −480 −452 234 −131 −706 −1773 −348 −779 −656 −418 −324 −1362 −922419 — −149 −500 233 43 −381 399 106 −626 210 −466 −720 275 394 45 96 359117 −369 −294 −249 — −16 −7108 −8150 −894 −1115 −701 −1378 * * 399(V−1742 −1294 −4287 −3868 −1507 −3983 −3425 2151 −3706 586 −316 −3621−3770 −3449 −3709 −3254 −1716 2871 −2925 −2571 420 — −149 −500 233 43−381 399 106 −626 210 −466 −720 275 394 45 96 359 117 −369 −294 −249 —−16 −7108 −8150 −894 −1115 −701 −1378 * * 400(D −730 −2244 2028 1115−2543 −1450 −283 −2307 1800 −2248 −1364 −74 −1665 147 −498 −571 502−1859 −2424 −1702 421 — −149 −500 233 43 −381 399 106 −626 210 −466 −720275 394 45 96 359 117 −369 −294 −249 — −16 −7108 −8150 −894 −1115 −701−1378 * * 401(N −410 −1793 −248 958 −2083 −143 −54 −1808 1270 −1797 −8981557 −1482 391 −146 −306 586 53 −2000 −1340 422 — −149 −500 233 43 −381399 106 −626 210 −466 −720 275 394 45 96 359 117 −369 −294 −249 — −16−7108 −8150 −894 −1115 −701 −1378 * * 402(Q −430 −1511 −419 58 −1825 563−219 −1494 116 −1597 −764 1033 −1570 1217 −353 1025 −404 892 −1898 −1308423 — −149 −500 233 43 −381 399 106 −626 210 −466 −720 275 394 45 96 359117 −369 −294 −249 — −16 −7108 −8150 −894 −1115 −701 −1378 * * 403(K 42−2025 1238 279 −2338 −1408 −138 −2090 1948 −2034 −1127 1026 −1554 1361−253 −410 −491 −1645 −2204 −1512 424 — −149 −500 233 43 −381 399 106−626 210 −466 −720 275 394 45 96 359 117 −369 −294 −249 — −16 −7108−8150 −894 −1115 −701 −1378 * * 404(E) −625 −2031 −279 1765 −2367 −1499−161 −2087 353 −2026 −1140 −139 1309 1668 922 −500 −559 −1667 −2180−1544 425 — −149 −500 233 43 −381 399 106 −626 210 −466 −720 275 394 4596 359 117 −369 −294 −249 — −1300 −7108 −769 −894 −1115 −701 −1378 * *405(Y −1580 −1211 −2445 −2254 2497 −2497 449 −742 −1944 −476 −322 −1430−2471 −1343 −1796 −1668 −1507 −820 1088 3543 426 — −149 −500 233 43 −381399 106 −626 210 −466 −720 275 394 45 96 359 117 −369 −294 −249 — −38−5845 −6888 −894 −1115 −560 −1636 * * 406(G −1371 −2394 1717 −285 −33913003 −1248 −3345 −1454 −3349 −2666 −589 −2148 −975 −2092 −1270 −1563−2745 −3295 −2730 427 — −149 −500 233 43 −381 399 106 −626 210 −466 −720275 394 45 96 359 117 −369 −294 −249 — −19 −6850 −7893 −894 −1115 −1215−813 * * 407(H 1177 −1467 −267 124 −1912 −1286 2549 −1618 132 −1695 −8521230 −1499 193 −333 681 −372 −1236 −1957 −1349 428 — −149 −500 233 43−381 399 106 −626 210 −466 −720 275 394 45 96 359 117 −369 −294 −249 —−19 −6850 −7893 −894 −1115 −1215 −813 * * 408(N −352 −1085 −738 −561−1975 1933 −822 −1555 −672 −1841 −1078 2120 −1685 −547 −1041 −473 −532758 −2198 −1695 429 — −149 −500 233 43 −381 399 106 −626 210 −466 −720275 394 45 96 359 117 −369 −294 −249 — −725 −6850 −1371 −894 −1115 −1215−813 * * 409(W −643 −1210 −455 1427 −532 −1453 −184 −970 −26 −1073 −478−390 −1652 −90 −302 −705 −607 −812 4240 −180 430 — −149 −500 233 43 −381399 106 −626 210 −466 −720 275 394 45 96 359 117 −369 −294 −249 — −348−6155 −2320 −894 −1115 −1881 −457 * * 410(G −461 −838 −976 −1119 −21203148 −1219 −2101 −1326 −2273 −1700 −986 −1505 −1212 −1430 −653 −781−1558 −1923 −1928 431 — −149 −500 233 43 −381 399 106 −626 210 −466 −720275 394 45 96 359 117 −369 −294 −249 — −38 −5845 −6888 −894 −1115 −560−1636 * * 411(Q −389 −1056 −645 768 −1124 −1508 −222 −612 34 219 −187−343 −1598 1815 −346 −489 −329 1199 −1410 −918 432 — −149 −500 233 43−381 399 106 −626 210 −466 −720 275 394 45 96 359 117 −369 −294 −249 —−19 −6850 −7893 −894 −1115 −453 −1893 * * 412(F) 523 −749 −1182 −6121262 −1690 −436 −327 1202 257 75 −713 −1761 −315 572 −681 −361 558 −1146−721 433 — −149 −500 233 43 −381 399 106 −626 210 −466 −720 275 394 4596 359 117 −369 −294 −249 — −16 −7108 −8150 −894 −1115 −701 −1378 * *413(Q −838 −2270 27 1546 −2609 −1503 −383 −2361 −43 −2318 −1463 −158−1752 2803 −531 937 −810 −1929 −2497 −1800 434 — −149 −500 233 43 −381399 106 −626 210 −466 −720 275 394 45 96 359 117 −369 −294 −249 — −16−7108 −8150 −894 −1115 −701 −1378 * * 414(D 2081 −2191 2846 −271 −3192−1547 −1150 −2913 −1247 −3052 −2319 −548 −2085 −840 −1860 −1066 −1314−2364 −3266 −2572 435 — −149 −500 233 43 −381 399 106 −626 210 −466 −720275 394 45 96 359 117 −369 −294 −249 — −16 −7108 −8150 −894 −1115 −701−1378 * * 415(M 746 −729 −1725 −1241 −1091 −1556 −930 −594 −1043 −9223667 −1111 404 −891 −1250 −698 914 −410 −1509 −1123 436 — −149 −500 23343 −381 399 106 −626 210 −466 −720 275 394 45 96 359 117 −369 −294 −249— −16 −7108 −8150 −894 −1115 −701 −1378 * * 416(I) −556 −796 −1468 −861−813 −1848 −559 1435 1067 271 42 −912 −1905 −460 1342 −865 −488 747−1213 −814 437 — −149 −500 233 43 −381 399 106 −626 210 −466 −720 275394 45 96 359 117 −369 −294 −249 — −16 −7108 −8150 −894 −1115 −701−1378 * * 417(E) 738 −1306 −528 1243 −1448 −1471 −165 −1079 130 −90 −452−231 −1559 192 330 328 268 267 −1616 −1069 438 — −149 −500 233 43 −381399 106 −626 210 −466 −720 275 394 45 96 359 117 −369 −294 −249 — −16−7108 −8150 −894 −1115 −701 −1378 * * 418(W −1686 −1388 −3865 −3280 −313−3346 −1998 1605 −2910 2183 589 −2918 −3142 −2351 −2689 −2486 −1602 −2163506 −1080 439 — −149 −500 233 43 −381 399 106 −626 210 −466 −720 275394 45 96 359 117 −369 −294 −249 — −16 −7108 −8150 −894 −1115 −701−1378 * * 419(G −497 −1132 −1973 −2195 −3328 3237 −2289 −3194 −2532−3410 −2549 −1611 −2057 −2201 −2603 897 −926 −2151 −3487 −3237 440 —−149 −500 233 43 −381 399 106 −626 210 −466 −720 275 394 45 96 359 117−369 −294 −249 — −16 −7108 −8150 −894 −1115 −701 −1378 * * 420(K 632−1777 1362 250 −2087 −1381 −86 −1807 1431 −1808 −914 −51 −1497 355 −193817 −369 −425 −2019 −1362 441 — −149 −500 233 43 −381 399 106 −626 210−466 −720 275 394 45 96 359 117 −369 −294 −249 — −16 −7108 −8150 −894−1115 −701 −1378 * * 421(Y −3621 −2707 −4176 −4424 2953 −4049 −394 −2539−4002 −1942 −1987 −2749 −3933 −2854 −3451 −3299 −3499 −2690 349 4093 442— −149 −500 233 43 −381 399 106 −626 210 −466 −720 275 394 45 96 359 117−369 −294 −249 — −16 −7108 −8150 −894 −1115 −701 −1378 * * 422(C −6421771 −2908 −2287 1063 −2214 −1093 1477 −1913 1497 494 −1833 −2239 −1538−1745 −1304 765 369 −942 −612 443 — −149 −500 233 43 −381 399 106 −626210 −466 −720 275 394 45 96 359 117 −369 −294 −249 — −16 −7108 −8150−894 −1115 −701 −1378 * * 423(R −1005 −2443 1533 92 −2784 −1584 −463−2543 −57 −2471 −1639 1177 −1853 −56 2770 −836 −972 −2113 −2612 −1931444 — −149 −500 233 43 −381 399 106 −626 210 −466 −720 275 394 45 96 359117 −369 −294 −249 — −16 −7108 −8150 −894 −1115 −701 −1378 * * 424(D−1148 −2724 2898 174 −3006 −1564 −566 −2796 951 −2711 −1895 −178 −19031815 −851 −933 −1132 −2344 −2872 −2108 445 — −149 −500 233 43 −381 399106 −626 210 −466 −720 275 394 45 96 359 117 −369 −294 −249 — −16 −7108−8150 −894 −1115 −701 −1378 * * 425(V −1646 −1230 −4148 −3696 −1391−3782 −3103 2535 −3497 −323 1927 −3416 −3609 −3214 −3466 −3018 −16162552 −2681 −2340 446 — −149 −500 233 43 −381 399 106 −626 210 −466 −720275 394 45 96 359 117 −369 −294 −249 — −16 −7108 −8150 −894 −1115 −701−1378 * * 426(I) 401 −900 −3283 −2756 1640 −2752 −1735 2834 −2451 −121132 −2375 −2775 −2110 −2360 −1897 −1085 615 −1519 −1079 447 — −149 −500233 43 −381 399 106 −626 210 −466 −720 275 394 45 96 359 117 −369 −294−249 — −16 −7108 −8150 −894 −1115 −701 −1378 * * 427(K −834 −1941 −615845 −2257 −1704 −312 −1778 2586 −1890 −1101 −402 −1823 95 65 −764 −756788 −2124 −1599 448 — −149 −500 233 43 −381 399 106 −626 210 −466 −720275 394 45 96 359 117 −369 −294 −249 — −16 −7108 −8150 −894 −1115 −701−1378 * * 428(N −857 −1859 −733 −254 −2082 −1745 −340 −1726 1897 679−1022 2134 −1861 45 77 −813 −778 −1455 −2024 −1510 449 — −149 −500 23343 −381 399 106 −626 210 −466 −720 275 394 45 96 359 117 −369 −294 −249— −16 −7108 −8150 −894 −1115 −701 −1378 * * 429(N −2171 −2655 −1458−1748 −3334 −2364 −2267 −3943 −2365 −3936 −3437 4205 −2932 −2205 −2608−2224 −2439 −3392 −3253 −2909 450 — −149 −500 233 43 −381 399 106 −626210 −466 −720 275 394 45 96 359 117 −369 −294 −249 — −16 −7108 −8150−894 −1115 −701 −1378 * * 430(P) −1140 −1553 −2272 −2156 −1935 −1979−1912 −1526 −1824 −1503 1339 −1897 3724 −1871 −1917 −1397 −1391 −1428−2485 −2072 451 — −149 −500 233 43 −381 399 106 −626 210 −466 −720 275394 45 96 359 117 −369 −294 −249 — −16 −7108 −8150 −894 −1115 −701−1378 * * 431(H −464 −1881 1234 255 −2190 −1407 2368 −1921 1008 −1884−981 −50 −1513 375 482 −349 1263 −1498 −2063 −1403 452 — −149 −500 23343 −381 399 106 −626 210 −466 −720 275 394 45 96 359 117 −369 −294 −249— −16 −7108 −8150 −894 −1115 −701 −1378 * * 432(N −761 −2121 1175 150−2581 −1441 −443 −2337 −205 −2327 −1467 2649 −1731 −36 −757 420 1163−1879 −2535 −1825 453 — −149 −500 233 43 −381 399 106 −626 210 −466 −720275 394 45 96 359 117 −369 −294 −249 — −16 −7108 −8150 −894 −1115 −701−1378 * * 433(F) −1857 −1592 −3755 −3460 3638 −3255 −1454 −16 −3144 −214−206 −2800 −3287 −2604 −2951 −2505 −1863 1480 −853 99 454 — −149 −500233 43 −381 399 106 −626 210 −466 −720 275 394 45 96 359 117 −369 −294−249 — −16 −7108 −8150 −894 −1115 −701 −1378 * * 434(R −2957 −3022 −3318−2735 −3796 −2998 −1968 −3912 −846 −3631 −3157 −2611 −3280 −1724 4056−3026 −2913 −3650 −3096 −3185 455 — −149 −500 233 43 −381 399 106 −626210 −466 −720 275 394 45 96 359 117 −369 −294 −249 — −16 −7108 −8150−894 −1115 −701 −1378 * * 435(L) −886 −722 −2913 −2339 −608 1022 −14231356 −2029 1682 294 −2025 −2497 −1718 −1972 −1579 −842 1130 −1337 −1008456 — −149 −500 233 43 −381 399 106 −626 210 −466 −720 275 394 45 96 359117 −369 −294 −249 — −16 −7108 −8150 −894 −1115 −701 −1378 * * 436(F)−3342 −2776 −4026 −4232 4354 −3545 −1431 −2315 −4038 −1801 −1900 −3299−3780 −3350 −3645 −3490 −3420 −2566 −739 349 457 — −149 −500 233 43 −381399 106 −626 210 −466 −720 275 394 45 96 359 117 −369 −294 −249 — −16−7108 −8150 −894 −1115 −701 −1378 * * 437(G −468 −1108 −1987 −2183 −33073093 −2261 −3159 −2489 −3374 −2507 −1593 −2035 −2163 −2570 1410 −895−2119 −3471 −3217 458 — −149 −500 233 43 −381 399 106 −626 210 −466 −720275 394 45 96 359 117 −369 −294 −249 — −16 −7108 −8150 −894 −1115 −701−1378 * * 438(H −30 439 11 363 −394 −739 699 −414 463 −757 501 286 −577639 165 −23 111 −312 697 −25 459 — −149 −500 233 43 −381 399 106 −626210 −466 −720 275 394 45 96 359 117 −369 −294 −249 — −16 −7108 −8150−894 −1115 −701 −1378 * * 439(P) −2931 −2878 −3420 −3706 −4181 −2925−3468 −4621 −3859 −4490 −4165 −3491 4225 −3781 −3695 −3182 −3279 −4087−3594 −4064 460 — −149 −500 233 43 −381 399 106 −626 210 −466 −720 275394 45 96 359 117 −369 −294 −249 — −16 −7108 −8150 −894 −1115 −701−1378 * * 440(D −2784 −3432 4016 −1200 −4140 −2466 −2197 −4505 −2621−4365 −3956 −1551 −3014 −2039 −3232 −2593 −2938 −4046 −3710 −3552 461 —−149 −500 233 43 −381 399 106 −626 210 −466 −720 275 394 45 96 359 117−369 −294 −249 — −16 −7108 −8150 −894 −1115 −701 −1378 * * 441(E) −2641−3308 −896 3732 −3966 −2458 −2043 −4105 −2128 −4016 −3555 −1531 −2959−1842 −2560 −2479 −2750 −3722 −3563 −3385 462 — −149 −500 233 43 −381399 106 −626 210 −466 −720 275 394 45 96 359 117 −369 −294 −249 — −16−7108 −8150 −894 −1115 −701 −1378 * * 442(T) −439 −840 −1804 −1403 −1361−1523 −1133 −816 −1185 681 −536 −1214 −1931 −1069 −1378 642 2718 −603−1788 −1389 463 — −149 −500 233 43 −381 399 106 −626 210 −466 −720 275394 45 96 359 117 −369 −294 −249 — −16 −7108 −8150 −894 −1115 −701−1378 * * 443(A 1657 −1594 −404 1150 −1818 −1465 −154 −1471 969 −15661309 −173 −1572 248 −202 −422 −412 −1160 −1861 −1272 464 — −149 −500 23343 −381 399 106 −626 210 −466 −720 275 394 45 96 359 117 −369 −294 −249— −16 −7108 −8150 −894 −1115 −701 −1378 * * 444(S) −897 −1462 −2333−2543 −3185 −1640 −2474 −3294 −2686 −3497 −2780 −1973 −2360 −2483 −27033465 −1316 −2413 −3310 −3025 465 — −149 −500 233 43 −381 399 106 −626210 −466 −720 275 394 45 96 359 117 −369 −294 −249 — −16 −7108 −8150−894 −1115 −701 −1378 * * 445(N −2171 −2655 −1458 −1748 −3334 −2364−2267 −3943 −2365 −3936 −3437 4205 −2932 −2205 −2608 −2224 −2439 −3392−3253 −2909 466 — −149 −500 233 43 −381 399 106 −626 210 −466 −720 275394 45 96 359 117 −369 −294 −249 — −16 −7108 −8150 −894 −1115 −701−1378 * * 446(R −1905 −2715 −2334 −1200 −3487 −2506 −485 −2858 1904−2546 −1846 −1167 −2464 1439 3148 −1780 −1627 −2602 −2423 −2263 467 —−149 −500 233 43 −381 399 106 −626 210 −466 −720 275 394 45 96 359 117−369 −294 −249 — −16 −7108 −8150 −894 −1115 −701 −1378 * * 447(L) −2639−2158 −4642 −4194 1586 −4340 −2490 −51 −3890 2827 573 −3860 −3832 −2979−3524 −3629 −2524 −732 −1565 −1006 468 — −149 −500 233 43 −381 399 106−626 210 −466 −720 275 394 45 96 359 117 −369 −294 −249 — −16 −7108−8150 −894 −1115 −701 −1378 * * 448(Q −549 −1725 −324 98 −1793 −1481−198 −1668 163 −1723 −892 839 −1618 2328 −290 843 −499 −1331 −1882 1794469 — −149 −500 233 43 −381 399 106 −626 210 −466 −720 275 394 45 96 359117 −369 −294 −249 — −16 −7108 −8150 −894 −1115 −701 −1378 * * 449(A2109 −2374 1307 1077 −2738 326 −514 −2505 −344 −2485 −1647 −151 −1804−118 −934 −766 −932 −2058 −2698 −1950 470 — −149 −500 233 43 −381 399106 −626 210 −466 −720 275 394 45 96 359 117 −369 −294 −249 — −16 −7108−8150 −894 −1115 −701 −1378 * * 450(A 1280 −376 −2219 −1624 1011 −1905−779 1073 −1336 −235 411 −1368 −1975 −1065 −1339 339 580 955 −851 −492471 — −149 −500 233 43 −381 399 106 −626 210 −466 −720 275 394 45 96 359117 −369 −294 −249 — −16 −7108 −8150 −894 −1115 −701 −1378 * * 451(F)−2619 −2089 −3969 −3846 3011 −3673 −612 −1304 −3453 1530 −788 −2671−3552 −2584 −3066 −2851 −2522 −1556 92 2879 472 — −149 −500 233 43 −381399 106 −626 210 −466 −720 275 394 45 96 359 117 −369 −294 −249 — −16−7108 −8150 −894 −1115 −701 −1378 * * 452(E) 400 −2342 1163 2306 −2664−1461 −401 −2438 −168 −2392 −1527 −102 −1735 14 −743 947 −818 −1984−2583 −1837 473 — −149 −500 233 43 −381 399 106 −626 210 −466 −720 275394 45 96 359 117 −369 −294 −249 — −16 −7108 −8150 −894 −1115 −701−1378 * * 453(H −424 −834 −1231 −741 −1039 183 2171 −588 −582 −902 −199−797 −1793 −479 −878 −660 1442 1664 −1404 −972 474 — −149 −500 233 43−381 399 106 −626 210 −466 −720 275 394 45 96 359 117 −369 −294 −249 —−16 −7108 −8150 −894 −1115 −701 −1378 * * 454(T) −825 −1543 −1050 −931−2411 −1607 −1105 −2069 −661 −2229 −1555 −978 −2065 1333 −881 −930 3234−1676 −2544 −2072 475 — −149 −500 233 43 −381 399 106 −626 210 −466 −720275 394 45 96 359 117 −369 −294 −249 — −16 −7108 −8150 −894 −1115 −701−1378 * * 455(N −948 −2217 −192 −59 −2753 871 −516 −2480 1579 −2431−1604 2747 −1874 −115 −403 −831 −947 −2039 −2574 −1954 476 — −149 −500233 43 −381 399 106 −626 210 −466 −720 275 394 45 96 359 117 −369 −294−249 — −16 −7108 −8150 −894 −1115 −701 −1378 * * 456(R −2118 −2789 −2710−1441 −3626 −2635 −569 −2972 2088 −2636 −1971 −1337 −2591 −153 3343−2003 −1811 −2743 −2476 −2375 477 — −149 −500 233 43 −381 399 106 −626210 −466 −720 275 394 45 96 359 117 −369 −294 −249 — −276 −7108 −2582−894 −1115 −701 −1378 * * 457(Q −2077 −2533 −1425 −1467 −2808 −2285−1598 −3134 −1059 −2958 −2537 −1616 −2694 4251 −1184 −2087 −2168 −2871−2703 −2369 478 — −149 −500 233 43 −381 399 106 −626 210 −466 −720 275394 45 96 359 117 −369 −294 −249 — −19 −6850 −7893 −894 −1115 −1215−813 * * 458(W −3599 −2878 −3805 −3989 −1220 −3156 −2211 −3491 −3618−3057 −3027 −3568 −3532 −3525 −3338 −3829 −3720 −3529 6135 −830 479 —−149 −500 233 43 −381 399 106 −626 210 −466 −720 275 394 45 96 359 117−369 −294 −249 — −19 −6850 −7893 −894 −1115 −1215 −813 * * 459(M −718−1070 1476 −726 −732 −1903 −713 −152 −681 774 3189 −882 −1991 −541 −1003−968 −669 −221 −1408 −983 480 — −149 −500 233 43 −381 399 106 −626 210−466 −720 275 394 45 96 359 117 −369 −294 −249 — −19 −6850 −7893 −894−1115 −1215 −813 * * 460(E) 598 −1592 −123 1874 −1828 −1337 −104 −1490228 −43 −755 967 −1490 296 −254 −355 −375 −1164 −1876 −1258 481 — −149−500 233 43 −381 399 106 −626 210 −466 −720 275 394 45 96 359 117 −369−294 −249 — −19 −6850 −7893 −894 −1115 −1215 −813 * * 461(P) −556 −17441230 129 −2482 1292 −454 −2234 −252 −2255 −1403 −147 1758 −66 −790 781−633 −1727 −2476 −1801 482 — −149 −500 233 43 −381 399 106 −626 210 −466−720 275 394 45 96 359 117 −369 −294 −249 — −1043 −6850 −983 −894 −1115−1215 −813 * * 462(Y −1345 −1235 −1689 −1605 1266 −1964 117 −925 −1303−775 −592 −1236 −2169 −1119 −1309 −1450 −1367 −939 590 3938 483 — −149−500 233 43 −381 399 106 −626 210 −466 −720 275 394 45 96 359 117 −369−294 −249 — −38 −5845 −6888 −894 −1115 −560 −1636 * * 463(I) −1578 −1151−4046 −3597 −1151 −3733 −3046 3001 −3402 771 18 −3355 −3517 −3085 −3372−2981 −1545 1808 −2540 −2237 484 — −149 −500 233 43 −381 399 106 −626210 −466 −720 275 394 45 96 359 117 −369 −294 −249 — −19 −6850 −7893−894 −1115 −453 −1893 * * 464(H −620 −1972 −273 140 −2293 −1493 2910−2020 1123 −1988 −1114 1414 −1632 244 −127 1037 −563 −1615 −2160 −1523485 — −149 −500 233 43 −381 399 106 −626 210 −466 −720 275 394 45 96 359117 −369 −294 −249 — −16 −7108 −8150 −894 −1115 −701 −1378 * * 465(E)290 −1861 861 1446 981 −1390 −101 −1871 273 −1861 −968 953 303 339 −239−355 −411 −1463 −2069 −1398 486 — −149 −500 233 43 −381 399 106 −626 210−466 −720 275 394 45 96 359 117 −369 −294 −249 — −16 −7108 −8150 −894−1115 −701 −1378 * * 466(P) −546 −1977 862 1025 −2262 −1409 −155 −2002204 −546 −1086 −48 1748 1636 −313 −420 −495 −1582 −2175 −1489 487 — −149−500 233 43 −381 399 106 −626 210 −466 −720 275 394 45 96 359 117 −369−294 −249 — −16 −7108 −8150 −894 −1115 −701 −1378 * * 467(W −477 −661−1479 −920 −458 −1795 −520 −227 −729 −529 143 1513 −1868 −571 −958 304−420 1257 2766 1177 488 — −149 −500 233 43 −381 399 106 −626 210 −466−720 275 394 45 96 359 117 −369 −294 −249 — −16 −7108 −8150 −894 −1115−701 −1378 * * 468(D −2784 −3432 4016 −1200 −4140 −2466 −2197 −4505−2621 −4365 −3956 −1551 −3014 −2039 −3232 −2593 −2938 −4046 −3710 −3552489 — −149 −500 233 43 −381 399 106 −626 210 −466 −720 275 394 45 96 359117 −369 −294 −249 — −16 −7108 −8150 −894 −1115 −701 −1378 * * 469(Q−1336 −2814 130 2632 −3112 −1670 −702 −2921 −403 −2830 −2067 −313 −20372655 −853 −1120 −1328 −2494 −2954 −2238 490 — −149 −500 233 43 −381 399106 −626 210 −466 −720 275 394 45 96 359 117 −369 −294 −249 — −16 −7108−8150 −894 −1115 −701 −1378 * * 470(W −1164 −1540 661 −1080 2483 −22571994 −1245 −947 −1304 −742 745 −2310 −770 −1263 −1253 −1097 −1115 25551863 491 — −149 −500 233 43 −381 399 106 −626 210 −466 −720 275 394 4596 359 117 −369 −294 −249 — −16 −7108 −8150 −894 −1115 −701 −1378 * *471(M −459 −840 −1110 504 −907 −1674 −501 −397 −456 −727 3234 −715 −1788−352 −771 770 −419 680 −1288 −853 492 — −149 −500 233 43 −381 399 106−626 210 −466 −720 275 394 45 96 359 117 −369 −294 −249 — −16 −7108−8150 −894 −1115 −701 −1378 * * 472(H 1702 −1846 −317 119 −2155 −14801717 −1860 1008 −1870 −1009 1392 −1616 236 −157 −482 −520 −1482 −2080−1459 493 — −149 −500 233 43 −381 399 106 −626 210 −466 −720 275 394 4596 359 117 −369 −294 −249 — −16 −7108 −8150 −894 −1115 −701 −1378 * *473(P) 1735 −849 −2213 −1898 −1800 −1446 −1575 −902 −1724 −1568 −933−1474 2335 −1533 −1863 −706 −666 1535 −2237 −1882 494 — −149 −500 233 43−381 399 106 −626 210 −466 −720 275 394 45 96 359 117 −369 −294 −249 —−16 −7108 −8150 −894 −1115 −701 −1378 * * 474(K 373 −1864 703 990 −2179−1360 −29 −1928 1276 −1877 −955 4 −1460 1260 −124 542 486 −1483 −2049−1367 495 — −149 −500 233 43 −381 399 106 −626 210 −466 −720 275 394 4596 359 117 −369 −294 −249 — −16 −7108 −8150 −894 −1115 −701 −1378 * *475(G −2594 −2690 −3304 −3623 −4328 3747 −3462 −4761 −3953 −4671 −4212−3320 −3352 −3748 −3779 −2839 −2981 −4004 −3668 −4222 496 — −149 −500233 43 −381 399 106 −626 210 −466 −720 275 394 45 96 359 117 −369 −294−249 — −16 −7108 −8150 −894 −1115 −701 −1378 * * 476(R −1165 −2238 −1063−503 −2794 820 −418 −2401 526 −2281 −1492 −670 −2047 2040 2681 −1075−1064 −2048 −2328 −1916 497 — −149 −500 233 43 −381 399 106 −626 210−466 −720 275 394 45 96 359 117 −369 −294 −249 — −16 −7108 −8150 −894−1115 −701 −1378 * * 477(V −823 −660 −2789 −2196 −638 −2422 −1317 1842−1836 −191 1866 −1913 −2436 −1596 1039 −1512 −768 2028 −1296 −949 498 —−149 −500 233 43 −381 399 106 −626 210 −466 −720 275 394 45 96 359 117−369 −294 −249 — −16 −7108 −8150 −894 −1115 −701 −1378 * * 478(V −1748−1297 −4301 −3885 −1515 −3999 −3451 2579 −3726 585 −321 −3638 −3782−3470 −3730 −3273 −1722 2581 −2943 −2589 499 — −149 −500 233 43 −381 399106 −626 210 −466 −720 275 394 45 96 359 117 −369 −294 −249 — −16 −7108−8150 −894 −1115 −701 −1378 * * 479(D −1067 −2475 2632 1644 −2683 −1544−584 1013 −469 −2422 −1654 −180 −1882 −209 −1071 −894 −1059 −1933 −2725−1977 500 — −149 −500 233 43 −381 399 106 −626 210 −466 −720 275 394 4596 359 117 −369 −294 −249 — −340 −7108 −2304 −894 −1115 −701 −1378 * *480(S) 717 −1527 −107 1500 −2213 −1229 −377 −1911 −112 −1988 −1149 −164−1554 7 −597 1919 −503 −1461 −2242 −1620 501 — −149 −500 233 43 −381 399106 −626 210 −466 −720 275 394 45 96 359 117 −369 −294 −249 — −20 −6788−7830 −894 −1115 −421 −1984 * * 481(Q −790 −1076 −1563 −1026 −923 −2037−834 −178 −669 −369 1897 −1109 −2120 2919 −906 −1087 −746 1186 −1510−1104 502 — −149 −500 233 43 −381 399 106 −626 210 −466 −720 275 394 4596 359 117 −369 −294 −249 — −16 −7108 −8150 −894 −1115 −701 −1378 * *482(L) −2871 −2457 −4231 −4103 −1033 −3803 −3165 −541 −3734 3130 −31−3935 −3797 −3286 −3484 −3713 −2869 −1136 −2394 −2220 503 — −149 −500233 43 −381 399 106 −626 210 −466 −720 275 394 45 96 359 117 −369 −294−249 — −16 −7108 −8150 −894 −1115 −701 −1378 * * 483(S) −897 −1462 −2333−2543 −3185 −1640 −2474 −3294 −2686 −3497 −2780 −1973 −2360 −2483 −27033465 −1316 −2413 −3310 −3025 504 — −149 −500 233 43 −381 399 106 −626210 −466 −720 275 394 45 96 359 117 −369 −294 −249 — −16 −7108 −8150−894 −1115 −701 −1378 * * 484(E) −2641 −3308 −896 3732 −3966 −2458 −2043−4105 −2128 −4016 −3555 −1531 −2959 −1842 −2560 −2479 −2750 −3722 −3563−3385 505 — −149 −500 233 43 −381 399 106 −626 210 −466 −720 275 394 4596 359 117 −369 −294 −249 — −16 −7108 −8150 −894 −1115 −701 −1378 * *485(H −3205 −3079 −2723 −2890 −2110 −3046 5295 −4135 −2617 −3813 −3561−2886 −3482 −2833 −2620 −3291 −3356 −3895 −2397 −1681 506 — −149 −500233 43 −381 399 106 −626 210 −466 −720 275 394 45 96 359 117 −369 −294−249 — −16 −7108 −8150 −894 −1115 −701 −1378 * * 486(Q −1064 −1426 −1517−1022 −242 −2170 −535 −884 −583 715 −396 −1085 −2235 −3051 −804 −1225−994 −864 −835 1693 507 — −149 −500 233 43 −381 399 106 −626 210 −466−720 275 394 45 96 359 117 −369 −294 −249 — −16 −7108 −8150 −894 −1115−701 −1378 * * 487(C 1096 3020 1354 −606 −1109 −1571 −566 −613 −497 −9391724 −707 −1762 −380 −838 −622 −428 −433 −1460 −1015 508 — −149 −500 23343 −381 399 106 −626 210 −466 −720 275 394 45 96 359 117 −369 −294 −249— −16 −7108 −8150 −894 −1115 −701 −1378 * * 488(E) −1401 −2897 169 3007−3185 −1677 −753 −3009 −498 −2916 −2170 −319 −2069 1880 −966 −1173 −1402−2580 −3040 −2307 509 — −149 −500 233 43 −381 399 106 −626 210 −466 −720275 394 45 96 359 117 −369 −294 −249 — −16 −7108 −8150 −894 −1115 −701−1378 * * 489(H −30 439 11 363 −394 −739 699 −414 463 −757 501 286 −577639 165 −23 111 −312 697 −25 510 — −149 −500 233 43 −381 399 106 −626210 −466 −720 275 394 45 96 359 117 −369 −294 −249 — −16 −7108 −8150−894 −1115 −701 −1378 * * 490(G −2594 −2690 −3304 −3623 −4328 3747 −3462−4761 −3953 −4671 −4212 −3320 −3352 −3748 −3779 −2839 −2981 −4004 −3668−4222 511 — −149 −500 233 43 −381 399 106 −626 210 −466 −720 275 394 4596 359 117 −369 −294 −249 — −16 −7108 −8150 −894 −1115 −701 −1378 * *491(W −2172 −1773 −3771 −3493 3388 −3396 −717 −939 −3099 −528 2179 −2555−3307 −2387 −2796 −2550 −2089 −1165 3733 1010 512 — −149 −500 233 43−381 399 106 −626 210 −466 −720 275 394 45 96 359 117 −369 −294 −249 —−16 −7108 −8150 −894 −1115 −701 −1378 * * 492(L) −2620 −2150 −4778 −4218−461 −4493 −3219 96 −3870 2765 2758 −4143 −3872 −3009 −3534 −3777 −2498−607 −2129 −2177 513 — −149 −500 233 43 −381 399 106 −626 210 −466 −720275 394 45 96 359 117 −369 −294 −249 — −16 −7108 −8150 −894 −1115 −701−1378 * * 493(E) −1401 −2897 169 3007 −3185 −1677 −753 −3009 −498 −2916−2170 −319 −2069 1880 −966 −1173 −1402 −2580 −3040 −2307 514 — −149 −500233 43 −381 399 106 −626 210 −466 −720 275 394 45 96 359 117 −369 −294−249 — −16 −7108 −8150 −894 −1115 −701 −1378 * * 494(G 2172 −1046 −2384−2525 −3259 2719 −2377 −2982 −2644 −3267 −2417 −1723 −2035 −2315 −2652−666 −864 −2010 −3440 −3255 515 — −149 −500 233 43 −381 399 106 −626 210−466 −720 275 394 45 96 359 117 −369 −294 −249 — −16 −7108 −8150 −894−1115 −701 −1378 * * 495(Y −3482 −2868 −3701 −3919 238 −3552 −1112 −3000−3638 −2516 −2526 −3027 −3772 −3101 −3341 −3418 −3527 −3071 −441 4711516 — −149 −500 233 43 −381 399 106 −626 210 −466 −720 275 394 45 96 359117 −369 −294 −249 — −16 −7108 −8150 −894 −1115 −701 −1378 * * 496(T)−971 −915 −2809 −2296 −857 −2442 −1626 433 −1998 1151 92 −2043 −2569−1769 −2033 −1592 2524 1200 −1666 −1332 517 — −149 −500 233 43 −381 399106 −626 210 −466 −720 275 394 45 96 359 117 −369 −294 −249 — −16 −7108−8150 −894 −1115 −701 −1378 * * 497(L) −2871 −2457 −4231 −4103 −1033−3803 −3165 −541 −3734 3130 −31 −3935 −3797 −3286 −3484 −3713 −2869−1136 −2394 −2220 518 — −149 −500 233 43 −381 399 106 −626 210 −466 −720275 394 45 96 359 117 −369 −294 −249 — −16 −7108 −8150 −894 −1115 −701−1378 * * 498(T) −1213 −1674 −2755 −2906 −3163 −1922 −2659 −2698 −2788−3105 −2612 −2311 −2600 −2708 −2753 −1463 3819 −2197 −3286 −3156 519 —−149 −500 233 43 −381 399 106 −626 210 −466 −720 275 394 45 96 359 117−369 −294 −249 — −16 −7108 −8150 −894 −1115 −701 −1378 * * 499(G −2594−2690 −3304 −3623 −4328 3747 −3462 −4761 −3953 −4671 −4212 −3320 −3352−3748 −3779 −2839 −2981 −4004 −3668 −4222 520 — −149 −500 233 43 −381399 106 −626 210 −466 −720 275 394 45 96 359 117 −369 −294 −249 — −16−7108 −8150 −894 −1115 −701 −1378 * * 500(R −2957 −3022 −3318 −2735−3796 −2998 −1968 −3912 −846 −3631 −3157 −2611 −3280 −1724 4056 −3026−2913 −3650 −3096 −3185 521 — −149 −500 233 43 −381 399 106 −626 210−466 −720 275 394 45 96 359 117 −369 −294 −249 — −16 −7108 −8150 −894−1115 −701 −1378 * * 501(H −999 −1647 −1206 −1105 −1780 −1755 4476 −2154−805 −2276 −1630 −1129 −2202 −979 −999 −1106 1428 −1786 −2106 −1395 522— −149 −500 233 43 −381 399 106 −626 210 −466 −720 275 394 45 96 359 117−369 −294 −249 — −16 −7108 −8150 −894 −1115 −701 −1378 * * 502(G −2594−2690 −3304 −3623 −4328 3747 −3462 −4761 −3953 −4671 −4212 −3320 −3352−3748 −3779 −2839 −2981 −4004 −3668 −4222 523 — −149 −500 233 43 −381399 106 −626 210 −466 −720 275 394 45 96 359 117 −369 −294 −249 — −16−7108 −8150 −894 −1115 −701 −1378 * * 503(I) −1567 −1223 −3950 −33992055 −3419 −2370 2527 −3104 944 309 −3048 −3245 −2620 −2927 −2582 −15071309 −1899 −1632 524 — −149 −500 233 43 −381 399 106 −626 210 −466 −720275 394 45 96 359 117 −369 −294 −249 — −16 −7108 −8150 −894 −1115 −701−1378 * * 504(W −3425 −2618 −4155 −4330 3859 −3949 −484 −2303 −3894−1728 −1759 −2779 −3865 −2847 −3389 −3247 −3323 −2490 3919 1426 525 —−149 −500 233 43 −381 399 106 −626 210 −466 −720 275 394 45 96 359 117−369 −294 −249 — −16 −7108 −8150 −894 −1115 −701 −1378 * * 505(A 2014−983 −1788 −1434 −2527 −1231 −1430 −2209 −1330 −2413 −1572 −1164 1491−1179 −1621 1494 990 −1548 −2719 −2324 526 — −149 −500 233 43 −381 399106 −626 210 −466 −720 275 394 45 96 359 117 −369 −294 −249 — −16 −7108−8150 −894 −1115 −701 −1378 * * 506(S) −352 −985 −2207 −2221 −3013 −1228−2099 −2715 −2192 −3001 −2167 −1553 −1952 −1978 −2279 3131 1106 −1840−3241 −2944 527 — −149 −500 233 43 −381 399 106 −626 210 −466 −720 275394 45 96 359 117 −369 −294 −249 — −16 −7108 −8150 −894 −1115 −701−1378 * * 507(Y −3482 −2868 −3701 −3919 238 −3552 −1112 −3000 −3638−2516 −2526 −3027 −3772 −3101 −3341 −3418 −3527 −3071 −441 4711 528 —−149 −500 233 43 −381 399 106 −626 210 −466 −720 275 394 45 96 359 117−369 −294 −249 — −16 −7108 −8150 −894 −1115 −701 −1378 * * 508(E) −2641−3308 −896 3732 −3966 −2458 −2043 −4105 −2128 −4016 −3555 −1531 −2959−1842 −2560 −2479 −2750 −3722 −3563 −3385 529 — −149 −500 233 43 −381399 106 −626 210 −466 −720 275 394 45 96 359 117 −369 −294 −249 — −16−7108 −8150 −894 −1115 −701 −1378 * * 509(S) 1981 −864 −2260 −1969 −2205−1291 −1697 −1605 −1808 −2070 −1333 −1448 −1910 −1601 −1958 2200 −636877 −2550 −2211 530 — −149 −500 233 43 −381 399 106 −626 210 −466 −720275 394 45 96 359 117 −369 −294 −249 — −16 −7108 −8150 −894 −1115 −701−1378 * * 510(F) −3342 −2776 −4026 −4232 4354 −3545 −1431 −2315 −4038−1801 −1900 −3299 −3780 −3350 −3645 −3490 −3420 −2566 −739 349 531 —−149 −500 233 43 −381 399 106 −626 210 −466 −720 275 394 45 96 359 117−369 −294 −249 — −16 −7108 −8150 −894 −1115 −701 −1378 * * 511(V −929−722 −3094 −2519 −671 72 −1536 1450 −2197 1669 235 −2159 −2584 −1873−2107 −1688 −882 1742 −1406 −1072 532 — −149 −500 233 43 −381 399 106−626 210 −466 −720 275 394 45 96 359 117 −369 −294 −249 — −16 −7108−8150 −894 −1115 −701 −1378 * * 512(R −1152 −2148 −1103 −556 −2568 8412681 −2297 448 −2220 −1446 −714 −2063 −63 2686 −1086 −1067 −1962 −2250−1802 533 — −149 −500 233 43 −381 399 106 −626 210 −466 −720 275 394 4596 359 117 −369 −294 −249 — −16 −7108 −8150 −894 −1115 −701 −1378 * *513(V −1261 −1032 −2990 401 −1324 −3032 −2128 1904 −2354 −591 −293 −2430−3023 −2199 −2472 −2185 −1232 2780 −2221 −1813 534 — −149 −500 233 43−381 399 106 −626 210 −466 −720 275 394 45 96 359 117 −369 −294 −249 —−16 −7108 −8150 −894 −1115 −701 −1378 * * 514(V −1755 −1298 −4332 −3970−1769 −4057 −3755 2730 −3843 −618 −544 −3732 −3880 −3701 −3920 −3374−1748 2759 −3277 −2831 535 — −149 −500 233 43 −381 399 106 −626 210 −466−720 275 394 45 96 359 117 −369 −294 −249 — −16 −7108 −8150 −894 −1115−701 −1378 * * 515(D −1718 −3250 3403 −27 −3066 −1736 2667 −3486 −1211−3381 −2732 −400 −2240 −752 −1917 −1439 −1784 −3023 −3204 −2299 536 —−149 −500 233 43 −381 399 106 −626 210 −466 −720 275 394 45 96 359 117−369 −294 −249 — −16 −7108 −8150 −894 −1115 −701 −1378 * * 516(S) −635−1657 1163 −252 −2614 −1382 −780 −2338 −601 −2421 −1582 −466 −1801 −415−1101 2397 1307 −1804 −2665 −2044 537 — −149 −500 233 43 −381 399 106−626 210 −466 −720 275 394 45 96 359 117 −369 −294 −249 — −16 −7108−8150 −894 −1115 −701 −1378 * * 517(M −2406 −2296 −3638 −3594 −1525−3105 −2824 −1047 −3121 −596 5043 −3293 −3425 −3046 −2996 −2911 −2552−1398 −2513 −2207 538 — −149 −500 233 43 −381 399 106 −626 210 −466 −720275 394 45 96 359 117 −369 −294 −249 — −16 −7108 −8150 −894 −1115 −701−1378 * * 518(M −2437 −1975 −4738 −4148 −487 −4369 −3139 1386 −3872 25242731 −4019 −3789 −2984 −3525 −3603 −2318 −374 −2113 −2174 539 — −149−500 233 43 −381 399 106 −626 210 −466 −720 275 394 45 96 359 117 −369−294 −249 — −16 −7108 −8150 −894 −1115 −701 −1378 * * 519(T) −504 −959−1413 −1049 −1473 −1580 −994 −629 −943 −1256 −601 1702 −1931 −837 −1224−750 1993 1780 −1865 −1432 540 — −149 −500 233 43 −381 399 106 −626 210−466 −720 275 394 45 96 359 117 −369 −294 −249 — −16 −7108 −8150 −894−1115 −701 −1378 * * 520(Q −2562 −2904 −1886 −1971 −3251 −2661 −2079−3690 −1565 −3469 −3081 −2107 −3091 4371 −1665 −2585 −2674 −3411 −3077−2821 541 — −149 −500 233 43 −381 399 106 −626 210 −466 −720 275 394 4596 359 117 −369 −294 −249 — −16 −7108 −8150 −894 −1115 −701 −1378 * *521(H −2992 −2589 −3064 −3043 863 −3512 4371 −2521 −2584 −2051 −1961−2327 −3545 −2255 −2492 −2815 −2919 −2563 158 3265 542 — −149 −500 23343 −381 399 106 −626 210 −466 −720 275 394 45 96 359 117 −369 −294 −249— −16 −7108 −8150 −894 −1115 −701 −1378 * * 522(F) 1777 −758 −2605 −20692426 −2201 −1138 17 −1776 −51 1943 −1762 −2314 −1474 −1762 −1320 −786−23 −1063 −575 543 — −149 −500 233 43 −381 399 106 −626 210 −466 −720275 394 45 96 359 117 −369 −294 −249 — −16 −7108 −8150 −894 −1115 −701−1378 * * 523(K −2620 −2961 −2461 −2046 −3743 −2791 −1570 −3603 3784−3387 −2839 −2048 −3039 −1260 −465 −2604 −2536 −3331 −3001 −2988 544 —−149 −500 233 43 −381 399 106 −626 210 −466 −720 275 394 45 96 359 117−369 −294 −249 — −16 −7108 −8150 −894 −1115 −701 −1378 * * 524(W −3358−2599 −4116 −4259 2442 −3892 −536 −2247 −3821 −1683 −1712 −2792 −3835−2843 −3352 −3227 −3271 −2441 5485 1363 545 — −149 −500 233 43 −381 399106 −626 210 −466 −720 275 394 45 96 359 117 −369 −294 −249 — −16 −7108−8150 −894 −1115 −701 −1378 * * 525(L) 841 −1175 −3469 −2926 −668 −3037−2058 1328 −2615 2287 379 −2642 −2978 −2226 −2526 −2188 −1355 301 −1760−1526 546 — −149 −500 233 43 −381 399 106 −626 210 −466 −720 275 394 4596 359 117 −369 −294 −249 — −16 −7108 −8150 −894 −1115 −701 −1378 * *526(R −837 −2176 −602 1392 −2587 −1688 −216 −2257 1534 −2141 −1281 1107−1779 227 −2109 −709 −741 −1854 −2229 −1683 547 — −149 −500 233 43 −381399 106 −626 210 −466 −720 275 394 45 96 359 117 −369 −294 −249 — −16−7108 −8150 −894 −1115 −701 −1378 * * 527(M 888 −1677 −357 850 −1922−1428 1639 −1611 1435 −1654 1807 −103 −1521 338 −129 −358 −369 −1259−1902 −1285 548 — −149 −500 233 43 −381 399 106 −626 210 −466 −720 275394 45 96 359 117 −369 −294 −249 — −16 −7108 −8150 −894 −1115 −701−1378 * * 528(A 2576 −902 −2349 −2158 −2756 −1202 −1937 −2410 −2031−2688 −1852 −1502 −1892 −1801 −2162 1022 1811 −1644 −3004 −2709 549 —−149 −500 233 43 −381 399 106 −626 210 −466 −720 275 394 45 96 359 117−369 −294 −249 — −16 −7108 −8150 −894 −1115 −701 −1378 * * 529(K −583−1746 −490 34 −1989 −1543 1732 −1666 1763 −1714 −880 1553 −1641 238 −31−516 −513 875 −1945 −1367 550 — −149 −500 233 43 −381 399 106 −626 210−466 −720 275 394 45 96 359 117 −369 −294 −249 — −1300 −7108 −769 −894−1115 −701 −1378 * * 530(R −915 −1387 −1141 −641 −1786 −1421 −246 −1638712 −1598 −1052 −657 −1663 43 3215 −962 −890 −1418 −1542 −1280 551 —−149 −500 233 43 −381 399 106 −626 210 −466 −720 275 394 45 96 359 117−369 −294 −249 — −38 −5845 −6888 −894 −1115 −238 −2716 * * 531(E) −1710−3547 2209 3007 −3749 −1634 −990 −3679 −1227 −3559 −2898 −238 −2166 −662−2065 −1376 −1779 −3163 −3720 −2744 552 — −149 −500 233 43 −381 399 106−626 210 −466 −720 275 394 45 96 359 117 −369 −294 −249 — −16 −7108−8150 −894 −1115 −701 −1378 * * 532(I) −599 −507 −2385 −1791 −457 −2112−969 1604 −1499 1009 366 −1553 −2152 765 −1506 −1178 1103 1145 −1019−667 553 — −149 −500 233 43 −381 399 106 −626 210 −466 −720 275 394 4596 359 117 −369 −294 −249 — −16 −7108 −8150 −894 −1115 −701 −1378 * *533(P) 787 −1572 724 108 −1851 −1418 −201 −1534 126 −1626 −789 −169 1640198 −358 575 −413 −1199 −1916 922 554 — −149 −500 233 43 −381 399 106−626 210 −466 −720 275 394 45 96 359 117 −369 −294 −249 — −16 −7108−8150 −894 −1115 −701 −1378 * * 534(W −4114 −3274 −4214 −4453 −1722−3496 −2681 −4109 −4149 −3619 −3615 −4044 −3885 −4032 −3816 −4355 −4248−4133 6191 −1329 555 — −149 −500 233 43 −381 399 106 −626 210 −466 −720275 394 45 96 359 117 −369 −294 −249 — −16 −7108 −8150 −894 −1115 −701−1378 * * 535(R −1940 −2623 −2163 −1317 −2718 −2498 2633 −2821 557 −2576−1920 −1294 −2549 −305 3406 −1859 −1734 −2575 −2279 −1885 556 — −149−500 233 43 −381 399 106 −626 210 −466 −720 275 394 45 96 359 117 −369−294 −249 — −16 −7108 −8150 −894 −1115 −701 −1378 * * 536(H −1345 −2440−1207 −576 −2915 −2072 3063 −2527 2588 −2343 −1569 −727 −2129 1381 532−1222 −1187 −2200 −2324 −1939 557 — −149 −500 233 43 −381 399 106 −626210 −466 −720 275 394 45 96 359 117 −369 −294 −249 — −16 −7108 −8150−894 −1115 −701 −1378 * * 537(D −695 −2182 1890 241 −2491 −1456 −249−2246 1496 −2187 −1300 −85 1264 1306 −385 −545 −648 −1804 −2357 −1656558 — −149 −500 233 43 −381 399 106 −626 210 −466 −720 275 394 45 96 359117 −369 −294 −249 — −16 −7108 −8150 −894 −1115 −701 −1378 * * 538(Y−1138 −876 −3345 −2810 −645 −2852 −1674 1928 −2488 −317 10 −2411 −2835−2166 −2393 −1984 −1094 2117 −1423 2681 559 — −149 −500 233 43 −381 399106 −626 210 −466 −720 275 394 45 96 359 117 −369 −294 −249 — −16 −7108−8150 −894 −1115 −701 −1378 * * 539(P) 1031 −974 −2031 −1918 −2925 −1207−1878 −2641 −1913 −2865 −2004 −1407 2879 −1695 −2096 1838 −694 −1790−3123 −2802 560 — −149 −500 233 43 −381 399 106 −626 210 −466 −720 275394 45 96 359 117 −369 −294 −249 — −16 −7108 −8150 −894 −1115 −701−1378 * * 540(H −30 439 11 363 −394 −739 699 −414 463 −757 501 286 −577639 165 −23 111 −312 697 −25 561 — −149 −500 233 43 −381 399 106 −626210 −466 −720 275 394 45 96 359 117 −369 −294 −249 — −16 −7108 −8150−894 −1115 −701 −1378 * * 541(S) 1737 −944 −2392 −2415 −3092 −1199 −2214−2801 −2395 −3086 −2226 −1614 −1940 −2116 −2445 2898 −735 −1863 −3322−3065 562 — −149 −500 233 43 −381 399 106 −626 210 −466 −720 275 394 4596 359 117 −369 −294 −249 — −16 −7108 −8150 −894 −1115 −701 −1378 * *542(M −1968 −1576 −4331 −3761 −611 −3859 −2765 1741 −3480 2227 2250−3502 −3515 −2812 −3229 −3049 −1885 1013 −2038 −1963 563 — −149 −500 23343 −381 399 106 −626 210 −466 −720 275 394 45 96 359 117 −369 −294 −249— −16 −7108 −8150 −894 −1115 −701 −1378 * * 543(N −2171 −2655 −1458−1748 −3334 −2364 −2267 −3943 −2365 −3936 −3437 4205 −2932 −2205 −2608−2224 −2439 −3392 −3253 −2909 564 — −149 −500 233 43 −381 399 106 −626210 −466 −720 275 394 45 96 359 117 −369 −294 −249 — −16 −7108 −8150−894 −1115 −701 −1378 * * 544(I) −1257 −1007 −3424 −2868 1397 −2811−1254 2188 −2500 1333 382 −2341 −2749 −1996 −2283 −1922 −1186 −115 −8152061 565 — −149 −500 233 43 −381 399 106 −626 210 −466 −720 275 394 4596 359 117 −369 −294 −249 — −16 −7108 −8150 −894 −1115 −701 −1378 * *545(I) −1831 −1391 −4327 −3871 −1200 −3991 −3265 2941 −3675 1302 −22−3631 −3727 −3275 −3598 −3245 −1791 1578 −2650 −2410 566 — −149 −500 23343 −381 399 106 −626 210 −466 −720 275 394 45 96 359 117 −369 −294 −249— −16 −7108 −8150 −894 −1115 −701 −1378 * * 546(E) 999 −1712 787 1203−1974 −1412 −152 −1661 194 −1721 −863 −101 −1546 266 −305 466 −419 822−1983 −1349 567 — −149 −500 233 43 −381 399 106 −626 210 −466 −720 275394 45 96 359 117 −369 −294 −249 — −16 −7108 −8150 −894 −1115 −701−1378 * * 547(T) 590 −1479 974 −206 −2293 −1346 −555 −1995 −272 −2077−1218 −407 −1671 −167 −745 1655 1771 −1514 −2333 −1741 568 — −149 −500233 43 −381 399 106 −626 210 −466 −720 275 394 45 96 359 117 −369 −294−249 — −16 −7108 −8150 −894 −1115 −701 −1378 * * 548(S) −897 −1462 −2333−2543 −3185 −1640 −2474 −3294 −2686 −3497 −2780 −1973 −2360 −2483 −27033465 −1316 −2413 −3310 −3025 569 — −149 −500 233 43 −381 399 106 −626210 −466 −720 275 394 45 96 359 117 −369 −294 −249 — −16 −7108 −8150−894 −1115 −701 −1378 * * 549(T) −866 −1511 −1211 −1054 −1813 −1680 2857−1969 −793 −2130 −1455 −1074 −2117 −914 −1013 −989 3041 −1609 −2119−1469 570 — −149 −500 233 43 −381 399 106 −626 210 −466 −720 275 394 4596 359 117 −369 −294 −249 — −16 −7108 −8150 −894 −1115 −701 −1378 * *550(W −587 −608 −2405 −1898 −479 −1928 −993 −42 −1552 −528 62 −1554−2129 −1332 −1550 365 −609 2511 3028 −502 571 — −149 −500 233 43 −381399 106 −626 210 −466 −720 275 394 45 96 359 117 −369 −294 −249 — −16−7108 −8150 −894 −1115 −701 −1378 * * 551(W 947 −1346 −3135 −2759 3172−2759 −620 −882 −2412 −912 −526 −2088 −2831 −1938 −2273 −1901 −1498 −8703648 929 572 — −149 −500 233 43 −381 399 106 −626 210 −466 −720 275 39445 96 359 117 −369 −294 −249 — −16 −7108 −8150 −894 −1115 −701 −1378 * *552(Q −1772 −2604 −1870 −1079 −3217 −2374 −569 −2777 660 −2529 −1835−1110 −2420 3075 2723 −1671 −1571 −2504 −2437 −2192 573 — −149 −500 23343 −381 399 106 −626 210 −466 −720 275 394 45 96 359 117 −369 −294 −249— −16 −7108 −8150 −894 −1115 −701 −1378 * * 553(Q −2562 −2904 −1886−1971 −3251 −2661 −2079 −3690 −1565 −3469 −3081 −2107 −3091 4371 −1665−2585 −2674 −3411 −3077 −2821 574 — −149 −500 233 43 −381 399 106 −626210 −466 −720 275 394 45 96 359 117 −369 −294 −249 — −16 −7108 −8150−894 −1115 −701 −1378 * * 554(D −1791 −3663 3414 1659 −3853 −1647 −1043−3807 −1343 −3679 −3054 −251 −2201 −725 −2227 −1438 −1872 −3282 −3836−2831 575 — −149 −500 233 43 −381 399 106 −626 210 −466 −720 275 394 4596 359 117 −369 −294 −249 — −16 −7108 −8150 −894 −1115 −701 −1378 * *555(H −3205 −3079 −2723 −2890 −2110 −3046 5295 −4135 −2617 −3813 −3561−2886 −3482 −2833 −2620 −3291 −3356 −3895 −2397 −1681 576 — −149 −500233 43 −381 399 106 −626 210 −466 −720 275 394 45 96 359 117 −369 −294−249 — −16 −7108 −8150 −894 −1115 −701 −1378 * * 556(N −2171 −2655 −1458−1748 −3334 −2364 −2267 −3943 −2365 −3936 −3437 4205 −2932 −2205 −2608−2224 −2439 −3392 −3253 −2909 577 — −149 −500 233 43 −381 399 106 −626210 −466 −720 275 394 45 96 359 117 −369 −294 −249 — −16 −7108 −8150−894 −1115 −701 −1378 * * 557(G −2594 −2690 −3304 −3623 −4328 3747 −3462−4761 −3953 −4671 −4212 −3320 −3352 −3748 −3779 −2839 −2981 −4004 −3668−4222 578 — −149 −500 233 43 −381 399 106 −626 210 −466 −720 275 394 4596 359 117 −369 −294 −249 — −16 −7108 −8150 −894 −1115 −701 −1378 * *558(Y −3620 −2706 −4179 −4428 3303 −4051 −393 −2536 −4005 −1939 −1984−2749 −3933 −2855 −3452 −3299 −3498 −2688 350 3843 579 — −149 −500 23343 −381 399 106 −626 210 −466 −720 275 394 45 96 359 117 −369 −294 −249— −16 −7108 −8150 −894 −1115 −701 −1378 * * 559(S) −344 −978 −2187 −2155−2953 −1227 −2035 −2643 −2108 −2926 −2093 −1523 −1940 −1902 −2216 29071859 −1800 −3181 −2875 580 — −149 −500 233 43 −381 399 106 −626 210 −466−720 275 394 45 96 359 117 −369 −294 −249 — −16 −7108 −8150 −894 −1115−701 −1378 * * 560(H −3205 −3079 −2723 −2890 −2110 −3046 5295 −4135−2617 −3813 −3561 −2886 −3482 −2833 −2620 −3291 −3356 −3895 −2397 −1681581 — −149 −500 233 43 −381 399 106 −626 210 −466 −720 275 394 45 96 359117 −369 −294 −249 — −16 −7108 −8150 −894 −1115 −701 −1378 * * 561(Q−2562 −2904 −1886 −1971 −3251 −2661 −2079 −3690 −1565 −3469 −3081 −2107−3091 4371 −1665 −2585 −2674 −3411 −3077 −2821 582 — −149 −500 233 43−381 399 106 −626 210 −466 −720 275 394 45 96 359 117 −369 −294 −249 —−16 −7108 −8150 −894 −1115 −701 −1378 * * 562(D −1724 −3448 3411 103−3726 −1642 −1058 −3734 −1342 −3628 −2991 1884 −2196 −745 −2191 −1408−1822 −3197 −3743 −2768 583 — −149 −500 233 43 −381 399 106 −626 210−466 −720 275 394 45 96 359 117 −369 −294 −249 — −16 −7108 −8150 −894−1115 −701 −1378 * * 563(P) −2931 −2878 −3420 −3706 −4181 −2925 −3468−4621 −3859 −4490 −4165 −3491 4225 −3781 −3695 −3182 −3279 −4087 −3594−4064 584 — −149 −500 233 43 −381 399 106 −626 210 −466 −720 275 394 4596 359 117 −369 −294 −249 — −16 −7108 −8150 −894 −1115 −701 −1378 * *564(G −468 −1108 −1987 −2183 −3307 3093 −2261 −3159 −2489 −3374 −2507−1593 −2035 −2163 −2570 1410 −895 −2119 −3471 −3217 585 — −149 −500 23343 −381 399 106 −626 210 −466 −720 275 394 45 96 359 117 −369 −294 −249— −16 −7108 −8150 −894 −1115 −701 −1378 * * 565(V 371 −671 −3209 −26181562 −2580 −1515 1368 −2275 648 269 −2195 −2574 −1917 −2132 −1689 −8522127 −1337 −1001 586 — −149 −500 233 43 −381 399 106 −626 210 −466 −720275 394 45 96 359 117 −369 −294 −249 — −16 −7108 −8150 −894 −1115 −701−1378 * * 566(T) −1238 −1032 −3270 −2717 −705 −2883 −1871 1700 −24011666 301 −2442 −2848 −2072 −2345 −2015 1957 452 −1675 −1395 587 — −149−500 233 43 −381 399 106 −626 210 −466 −720 275 394 45 96 359 117 −369−294 −249 — −16 −7108 −8150 −894 −1115 −701 −1378 * * 567(T) −307 −965−2051 −1918 −2899 1272 −1866 −2617 −1903 −2838 −1975 −1405 −1889 −1683−2089 1577 2739 −1773 −3100 −2780 588 — −149 −500 233 43 −381 399 106−626 210 −466 −720 275 394 45 96 359 117 −369 −294 −249 — −16 −7108−8150 −894 −1115 −701 −1378 * * 568(H 837 −578 −1703 −1139 −579 −18222864 −45 −902 −418 1836 −1086 −1915 −740 −1071 −867 −423 1342 −1041 −648589 — −149 −500 233 43 −381 399 106 −626 210 −466 −720 275 394 45 96 359117 −369 −294 −249 — −16 −7108 −8150 −894 −1115 −701 −1378 * * 569(L)−2092 −1719 −4323 −3846 −712 −3925 −2989 451 −3531 2641 428 −3624 −3640−2952 −3339 −3191 −2044 1542 −2221 −2096 590 — −149 −500 233 43 −381 399106 −626 210 −466 −720 275 394 45 96 359 117 −369 −294 −249 — −16 −7108−8150 −894 −1115 −701 −1378 * * 570(L) 1056 −648 −2733 −2160 1291 −2277−874 5 −1827 1649 341 −1760 −2303 −1464 −1729 −1359 −733 −2 −647 1605591 — −149 −500 233 43 −381 399 106 −626 210 −466 −720 275 394 45 96 359117 −369 −294 −249 — −16 −7108 −8150 −894 −1115 −701 −1378 * * 571(E)−994 −2497 67 2352 −2818 −1564 −437 −2572 1391 −2487 −1645 1818 −1831−24 −503 −812 −956 −2133 −2633 −1933 592 — −149 −500 233 43 −381 399 106−626 210 −466 −720 275 394 45 96 359 117 −369 −294 −249 — −16 −7108−8150 −894 −1115 −701 −1378 * * 572(K −1592 −2196 −1883 −1179 −2203−2360 −733 −1718 3129 666 −1212 −1218 −2435 −383 258 −1621 −1460 −1669−2199 −1837 593 — −149 −500 233 43 −381 399 106 −626 210 −466 −720 275394 45 96 359 117 −369 −294 −249 — −971 −7108 −1051 −894 −1115 −701−1378 * * 573(C −39 2488 −473 1144 −1043 −1085 −142 −526 67 −851 −125−185 −1325 126 −296 −170 1058 −295 −1316 −837 594 — −149 −500 233 43−381 399 106 −626 210 −466 −720 275 394 45 96 359 117 −369 −294 −249 —−360 −6167 −2274 −894 −1115 −1874 −459 * * 574(F) −1315 −1110 −2234−2129 3522 −2099 −247 −203 −1900 58 60 −1632 −2283 −1510 −1804 −1624−1357 −396 303 1334 595 — −149 −500 233 43 −381 399 106 −626 210 −466−720 275 394 45 96 359 117 −369 −294 −249 — −38 −5845 −6888 −894 −1115−2039 −402 * * 575(H −354 −1360 326 436 −1031 −1026 2689 −1410 436 −1450−724 1667 −1303 383 89 −286 −351 −1096 −1280 −501 596 — −149 −500 233 43−381 399 106 −626 210 −466 −720 275 394 45 96 359 117 −369 −294 −249 —−38 −5845 −6888 −894 −1115 −238 −2716 * * 576(K −1086 −2304 −1032 −362−2797 −1910 −283 −2399 2361 −2235 −1413 1695 −1959 1479 1362 −963 −952−2031 −2264 −1826 597 — −149 −500 233 43 −381 399 106 −626 210 −466 −720275 394 45 96 359 117 −369 −294 −249 — −16 −7108 −8150 −894 −1115 −701−1378 * * 577(P) −1766 −2832 2091 −503 −3634 −1897 −1480 −3629 −1677−3608 −2962 −830 3445 −1206 −2322 −1624 −1926 −3087 −3516 −2951 598 —−149 −500 233 43 −381 399 106 −626 210 −466 −720 275 394 45 96 359 117−369 −294 −249 — −16 −7108 −8150 −894 −1115 −701 −1378 * * 578(H −480−1902 1434 926 −2176 −1399 2271 −1932 300 −1903 −1004 −39 −1521 347 782−362 −423 −1511 −2083 1389 599 — −149 −500 233 43 −381 399 106 −626 210−466 −720 275 394 45 96 359 117 −369 −294 −249 — −16 −7108 −8150 −894−1115 −701 −1378 * * 579(Y 839 −383 −2642 −2032 1206 −2056 −863 223−1678 569 461 −1617 −2100 −1333 −1555 −1135 −472 1465 −747 1987 600 —−149 −500 233 43 −381 399 106 −626 210 −466 −720 275 394 45 96 359 117−369 −294 −249 — −16 −7108 −8150 −894 −1115 −701 −1378 * * 580(I) 865−836 −3163 −2646 −1108 −2692 −1893 2677 −2382 −556 −157 −2324 −2771−2135 −2380 −1845 504 1519 −1868 −1491 601 — −149 −500 233 43 −381 399106 −626 210 −466 −720 275 394 45 96 359 117 −369 −294 −249 — −16 −7108−8150 −894 −1115 −701 −1378 * * 581(R −1066 −2251 −943 −347 −2740 308−313 −2349 1342 −2216 −1401 854 −1954 119 2761 −953 −949 −1986 −2272−1823 602 — −149 −500 233 43 −381 399 106 −626 210 −466 −720 275 394 4596 359 117 −369 −294 −249 — −16 −7108 −8150 −894 −1115 −701 −1378 * *582(E) −370 −640 −961 1875 −770 −1558 −279 900 −284 −670 84 −547 −1598−160 −606 −577 −301 965 −907 −668 603 — −149 −500 233 43 −381 399 106−626 210 −466 −720 275 394 45 96 359 117 −369 −294 −249 — −16 −7108−8150 −894 −1115 −701 −1378 * * 583(Y −3618 −2707 −4172 −4418 2748 −4047−395 −2537 −3997 −1940 −1986 −2748 −3932 −2853 −3448 −3297 −3496 −2688348 4199 604 — −149 −500 233 43 −381 399 106 −626 210 −466 −720 275 39445 96 359 117 −369 −294 −249 — −16 −7108 −8150 −894 −1115 −701 −1378 * *584(F) −2597 −2122 −4519 −4116 2769 −4202 −2114 −140 −3797 2428 469−3639 −3772 −2912 −3436 −3471 −2488 −783 −1265 −532 605 — −149 −500 23343 −381 399 106 −626 210 −466 −720 275 394 45 96 359 117 −369 −294 −249— −16 −7108 −8150 −894 −1115 −701 −1378 * * 585(P) 1615 −1136 −2222−2310 −3082 −1373 −2227 −2731 −2358 −3036 −2272 −1689 3445 −2139 −2424−761 −938 −1937 −3279 −3042 606 — −149 −500 233 43 −381 399 106 −626 210−466 −720 275 394 45 96 359 117 −369 −294 −249 — −16 −7108 −8150 −894−1115 −701 −1378 * * 586(A 2397 −935 −2082 −1846 −2575 −1236 −1722 −2190−1737 −2475 −1666 −1377 1554 −1552 −1929 −527 1772 −1532 −2826 −2490 607— −149 −500 233 43 −381 399 106 −626 210 −466 −720 275 394 45 96 359 117−369 −294 −249 — −16 −7108 −8150 −894 −1115 −701 −1378 * * 587(D −2784−3432 4016 −1200 −4140 −2466 −2197 −4505 −2621 −4365 −3956 −1551 −3014−2039 −3232 −2593 −2938 −4046 −3710 −3552 608 — −149 −500 233 43 −381399 106 −626 210 −466 −720 275 394 45 96 359 117 −369 −294 −249 — −16−7108 −8150 −894 −1115 −701 −1378 * * 588(A 3098 −930 −2580 −2583 −2894−1243 −2249 −2309 −2448 −2781 −2022 −1697 −1976 −2194 −2449 −591 1113−1602 −3196 −2952 609 — −149 −500 233 43 −381 399 106 −626 210 −466 −720275 394 45 96 359 117 −369 −294 −249 — −16 −7108 −8150 −894 −1115 −701−1378 * * 589(N −2171 −2655 −1458 −1748 −3334 −2364 −2267 −3943 −2365−3936 −3437 4205 −2932 −2205 −2608 −2224 −2439 −3392 −3253 −2909 610 —−149 −500 233 43 −381 399 106 −626 210 −466 −720 275 394 45 96 359 117−369 −294 −249 — −16 −7108 −8150 −894 −1115 −701 −1378 * * 590(M −387−854 −1643 −1199 −1437 −1461 −1020 −962 −1012 −1269 2610 −1075 −1857−895 −1259 1806 1865 −709 −1810 −1406 611 — −149 −500 233 43 −381 399106 −626 210 −466 −720 275 394 45 96 359 117 −369 −294 −249 — −16 −7108−8150 −894 −1115 −701 −1378 * * 591(H −30 439 11 363 −394 −739 699 −414463 −757 501 286 −577 639 165 −23 111 −312 697 −25 612 — −149 −500 23343 −381 399 106 −626 210 −466 −720 275 394 45 96 359 117 −369 −294 −249— −16 −7108 −8150 −894 −1115 −701 −1378 * * 592(L) −2625 −2145 −4613−4174 1968 −4304 −2386 −72 −3866 2741 551 −3801 −3814 −2959 −3500 −3585−2511 −745 −1483 −874 613 — −149 −500 233 43 −381 399 106 −626 210 −466−720 275 394 45 96 359 117 −369 −294 −249 — −16 −7108 −8150 −894 −1115−701 −1378 * * 593(L) −2193 −1789 −4457 −3877 −523 −4057 −2894 279 −35842588 2231 −3689 −3624 −2841 −3310 −3261 −2096 1093 −2048 −2035 614 —−149 −500 233 43 −381 399 106 −626 210 −466 −720 275 394 45 96 359 117−369 −294 −249 — −16 −7108 −8150 −894 −1115 −701 −1378 * * 594(A 2970−925 −2555 −2528 −2849 −1243 −2202 −2276 −2388 −2737 −1975 −1675 −1968−2140 −2406 −585 1607 −1581 −3151 −2898 615 — −149 −500 233 43 −381 399106 −626 210 −466 −720 275 394 45 96 359 117 −369 −294 −249 — −16 −7108−8150 −894 −1115 −701 −1378 * * 595(V −1334 −1034 −3629 −3155 −1390−3214 −2516 2107 −2918 −591 −331 −2852 −3211 −2701 −2928 −2407 1824 2364−2380 −1985 616 — −149 −500 233 43 −381 399 106 −626 210 −466 −720 275394 45 96 359 117 −369 −294 −249 — −16 −7108 −8150 −894 −1115 −701−1378 * * 596(M 998 −406 −1988 −1399 1077 −46 −692 73 −1142 733 1731−1227 −1918 −903 −1209 286 −359 167 −855 −487 617 — −149 −500 233 43−381 399 106 −626 210 −466 −720 275 394 45 96 359 117 −369 −294 −249 —−16 −7108 −8150 −894 −1115 −701 −1378 * * 597(H −1095 −2732 1291 2125−2985 −1512 3032 −2799 −427 −2721 −1890 1256 −1861 −159 −1055 −875 −1088−2329 −2902 −2089 618 — −149 −500 233 43 −381 399 106 −626 210 −466 −720275 394 45 96 359 117 −369 −294 −249 — −16 −7108 −8150 −894 −1115 −701−1378 * * 598(H −971 −1917 −1026 −424 −2119 −1866 2995 −1811 2402 −1852−1093 −602 −1947 34 266 −932 −871 294 −1999 −1507 619 — −149 −500 233 43−381 399 106 −626 210 −466 −720 275 394 45 96 359 117 −369 −294 −249 —−16 −7108 −8150 −894 −1115 −701 −1378 * * 599(C 1836 3931 −2905 −2499−1252 −1823 −1705 1152 −2189 −888 −389 −1893 −2246 −1917 −2150 −1063−756 157 −1855 −1509 620 — −149 −500 233 43 −381 399 106 −626 210 −466−720 275 394 45 96 359 117 −369 −294 −249 — −16 −7108 −8150 −894 −1115−701 −1378 * * 600(F) 528 −777 −2899 −2354 2441 −2415 −823 −127 −20081363 215 −1876 −2433 −1604 −1876 −1506 −889 −142 −490 1736 621 — −149−500 233 43 −381 399 106 −626 210 −466 −720 275 394 45 96 359 117 −369−294 −249 — −16 −7108 −8150 −894 −1115 −701 −1378 * * 601(K −1239 −2390−1266 −522 −2934 −2031 −324 −2495 2422 −2300 −1501 979 −2062 1504 1964−1116 −1081 −2146 −2296 −1915 622 — −149 −500 233 43 −381 399 106 −626210 −466 −720 275 394 45 96 359 117 −369 −294 −249 — −16 −7108 −8150−894 −1115 −701 −1378 * * 602(S) 699 −1151 −903 −440 −1699 −1408 −579−1323 −350 −1526 1574 974 −1694 −269 −750 2107 −464 −1002 −1909 −1408623 — −149 −500 233 43 −381 399 106 −626 210 −466 −720 275 394 45 96 359117 −369 −294 −249 — −16 −7108 −8150 −894 −1115 −701 −1378 * * 603(Q−873 −2060 −736 −198 −2478 −1732 −282 −2118 1944 −2060 −1235 −426 −18361968 230 −780 1853 −1758 −2189 −1681 624 — −149 −500 233 43 −381 399 106−626 210 −466 −720 275 394 45 96 359 117 −369 −294 −249 — −16 −7108−8150 −894 −1115 −701 −1378 * * 604(N −1080 −2639 214 1668 −2924 −1545−527 −2711 −282 −2635 −1807 2572 −1867 2104 −814 −876 −1062 −2261 −2801−2043 625 — −149 −500 233 43 −381 399 106 −626 210 −466 −720 275 394 4596 359 117 −369 −294 −249 — −16 −7108 −8150 −894 −1115 −701 −1378 * *605(K −457 1622 −593 −29 −1532 −1520 −184 −1170 1745 −1320 −528 −275−1605 1259 −206 −467 609 −916 −1665 1434 626 — −149 −500 233 43 −381 399106 −626 210 −466 −720 275 394 45 96 359 117 −369 −294 −249 — −16 −7108−8150 −894 −1115 −701 −1378 * * 606(I) −1995 −1561 −4353 −3926 −1045−4065 −3261 3346 −3652 924 94 −3716 −3783 −3240 −3554 −3362 −1957 705−2551 −2295 627 — −149 −500 233 43 −381 399 106 −626 210 −466 −720 275394 45 96 359 117 −369 −294 −249 — −16 −7108 −8150 −894 −1115 −701−1378 * * 607(N −2171 −2655 −1458 −1748 −3334 −2364 −2267 −3943 −2365−3936 −3437 4205 −2932 −2205 −2608 −2224 −2439 −3392 −3253 −2909 628 —−149 −500 233 43 −381 399 106 −626 210 −466 −720 275 394 45 96 359 117−369 −294 −249 — −16 −7108 −8150 −894 −1115 −701 −1378 * * 608(Y 1025−487 −2483 −1892 −336 −2087 −935 224 −1576 1270 403 −1587 −2140 −1281−1535 −1165 −537 999 −908 2074 629 — −149 −500 233 43 −381 399 106 −626210 −466 −720 275 394 45 96 359 117 −369 −294 −249 — −16 −7108 −8150−894 −1115 −701 −1378 * * 609(M −797 −587 −3073 −2468 1091 −2423 −13292169 −2112 −34 2364 −2036 −2429 −1745 −1959 −1522 645 1209 −1165 −836630 — −149 −500 233 43 −381 399 106 −626 210 −466 −720 275 394 45 96 359117 −369 −294 −249 — −16 −7108 −8150 −894 −1115 −701 −1378 * * 610(V−1573 −1179 −4043 −3576 867 −3627 −2822 2175 −3353 −312 −198 −3256 −3486−3047 −3296 −2841 −1540 2804 −2430 −2026 631 — −149 −500 233 43 −381 399106 −626 210 −466 −720 275 394 45 96 359 117 −369 −294 −249 — −16 −7108−8150 −894 −1115 −701 −1378 * * 611(A 2440 −912 −2339 −2201 −2840 1287−1997 −2505 −2116 −2780 −1935 −1522 −1901 −1868 −2234 −517 1851 −1699−3081 −2799 632 — −149 −500 233 43 −381 399 106 −626 210 −466 −720 275394 45 96 359 117 −369 −294 −249 — −16 −7108 −8150 −894 −1115 −701−1378 * * 612(S) −437 −1083 −2006 −2144 −3262 1583 −2197 −3097 −2380−3307 −2434 −1562 −2008 −2077 −2485 2965 −857 −2074 −3426 −3160 633 —−149 −500 233 43 −381 399 106 −626 210 −466 −720 275 394 45 96 359 117−369 −294 −249 — −16 −7108 −8150 −894 −1115 −701 −1378 * * 613(K −2620−2961 −2461 −2046 −3743 −2791 −1570 −3603 3784 −3387 −2839 −2048 −3039−1260 −465 −2604 −2536 −3331 −3001 −2988 634 — −149 −500 233 43 −381 399106 −626 210 −466 −720 275 394 45 96 359 117 −369 −294 −249 — −16 −7108−8150 −894 −1115 −701 −1378 * * 614(H −1501 −2478 −747 −589 −1969 −20333845 −2617 −5 −2483 −1816 −796 −2272 2881 −187 −1387 −1442 −2314 −2088−1345 635 — −149 −500 233 43 −381 399 106 −626 210 −466 −720 275 394 4596 359 117 −369 −294 −249 — −16 −7108 −8150 −894 −1115 −701 −1378 * *615(P) −2931 −2878 −3420 −3706 −4181 −2925 −3468 −4621 −3859 −4490 −4165−3491 4225 −3781 −3695 −3182 −3279 −4087 −3594 −4064 636 — −149 −500 23343 −381 399 106 −626 210 −466 −720 275 394 45 96 359 117 −369 −294 −249— −16 −7108 −8150 −894 −1115 −701 −1378 * * 616(R 1242 −1347 −1254 −731−2201 −1510 −719 −1792 −153 −1944 −1159 −782 −1844 −375 2580 −656 1294−1393 −2232 −1788 637 — −149 −500 233 43 −381 399 106 −626 210 −466 −720275 394 45 96 359 117 −369 −294 −249 — −16 −7108 −8150 −894 −1115 −701−1378 * * 617(P) 1448 −1164 −798 −305 −1387 −1533 −406 −980 −151 81 −453−488 1572 1113 −529 −556 −448 −759 −1638 −1144 638 — −149 −500 233 43−381 399 106 −626 210 −466 −720 275 394 45 96 359 117 −369 −294 −249 —−16 −7108 −8150 −894 −1115 −701 −1378 * * 618(Q −557 −1175 −1028 −563−1488 −1618 −611 −820 −317 −1222 −557 −696 −1835 2724 −638 −698 13781031 −1782 −1308 639 — −149 −500 233 43 −381 399 106 −626 210 −466 −720275 394 45 96 359 117 −369 −294 −249 — −16 −7108 −8150 −894 −1115 −701−1378 * * 619(W −3603 −2685 −4198 −4439 2092 −4053 −373 −2561 −4004−1981 −2004 −2736 −3927 −2842 −3443 −3284 −3472 −2688 5224 2885 640 —−149 −500 233 43 −381 399 106 −626 210 −466 −720 275 394 45 96 359 117−369 −294 −249 — −16 −7108 −8150 −894 −1115 −701 −1378 * * 620(F) −1507−1226 −3587 −3073 2681 −3022 −1217 950 −2707 1659 313 −2490 −2927 −2137−2464 −2143 −1430 −380 −687 1671 641 — −149 −500 233 43 −381 399 106−626 210 −466 −720 275 394 45 96 359 117 −369 −294 −249 — −16 −7108−8150 −894 −1115 −701 −1378 * * 621(S) −344 −978 −2188 −2158 −2955 −1227−2038 −2646 −2111 −2929 −2096 −1524 −1940 −1904 −2218 2919 1829 −1801−3183 −2878 642 — −149 −500 233 43 −381 399 106 −626 210 −466 −720 275394 45 96 359 117 −369 −294 −249 — −16 −7108 −8150 −894 −1115 −701−1378 * * 622(I) −1092 −874 −3179 −2611 −721 −2765 −1721 1891 −2310 1192241 −2311 1836 −1986 −2249 −1880 −1042 1298 −1570 −1257 643 — −149 −500233 43 −381 399 106 −626 210 −466 −720 275 394 45 96 359 117 −369 −294−249 — −16 −7108 −8150 −894 −1115 −701 −1378 * * 623(D −891 −2456 21611856 −2735 −1474 −410 −2519 −186 −2456 −1593 −91 −1753 1291 −767 −707782 −2062 −2639 −1876 644 — −149 −500 233 43 −381 399 106 −626 210 −466−720 275 394 45 96 359 117 −369 −294 −249 — −16 −7108 −8150 −894 −1115−701 −1378 * * 624(E) −2641 −3308 −896 3732 −3966 −2458 −2043 −4105−2128 −4016 −3555 −1531 −2959 −1842 −2560 −2479 −2750 −3722 −3563 −3385645 — −149 −500 233 43 −381 399 106 −626 210 −466 −720 275 394 45 96 359117 −369 −294 −249 — −16 −7108 −8150 −894 −1115 −701 −1378 * * 625(A3438 −1472 −2846 −3040 −3287 −1726 −2735 −2840 −3028 −3257 −2662 −2236−2447 −2798 −2944 −1216 −1387 −2183 −3405 −3320 646 — −149 −500 233 43−381 399 106 −626 210 −466 −720 275 394 45 96 359 117 −369 −294 −249 —−16 −7108 −8150 −894 −1115 −701 −1378 * * 626(K −719 −2060 −577 1623−2444 −1622 −164 −2125 1699 −2035 −1164 −266 −1703 282 1624 −601 634−1722 −2150 −1583 647 — −149 −500 233 43 −381 399 106 −626 210 −466 −720275 394 45 96 359 117 −369 −294 −249 — −16 −7108 −8150 −894 −1115 −701−1378 * * 627(Q 1243 −1432 −728 −405 −2358 −1377 −690 −2055 −351 −2150−1310 −555 −1744 2880 −751 1081 −618 −1561 −2401 −1849 648 — −149 −500233 43 −381 399 106 −626 210 −466 −720 275 394 45 96 359 117 −369 −294−249 — −16 −7108 −8150 −894 −1115 −701 −1378 * * 628(H −780 −1536 −5551361 −1393 −1709 2249 −1189 −144 1529 −640 −494 −1865 −169 −489 −816−724 −1022 −1690 −1099 649 — −149 −500 233 43 −381 399 106 −626 210 −466−720 275 394 45 96 359 117 −369 −294 −249 — −16 −7108 −8150 −894 −1115−701 −1378 * * 629(C 456 2634 −3043 −2479 −719 −2386 −1463 624 −21481022 146 −2055 −2467 −1831 −2047 −1515 −777 2135 −1370 −1020 650 — −149−500 233 43 −381 399 106 −626 210 −466 −720 275 394 45 96 359 117 −369−294 −249 — −16 −7108 −8150 −894 −1115 −701 −1378 * * 630(D 59 −19471795 1154 −2254 −1392 −111 −1999 273 −1959 −1053 −30 −1526 335 1177 −370709 −1564 −2142 −1456 651 — −149 −500 233 43 −381 399 106 −626 210 −466−720 275 394 45 96 359 117 −369 −294 −249 — −16 −7108 −8150 −894 −1115−701 −1378 * * 631(Q 1161 −1938 −287 164 −2274 −1471 −154 −1990 1104−1956 −1072 1604 −1598 1906 −101 −461 −513 −1579 −2132 −1496 652 — −149−500 233 43 −381 399 106 −626 210 −466 −720 275 394 45 96 359 117 −369−294 −249 — −16 −7108 −8150 −894 −1115 −701 −1378 * * 632(G −2594 −2690−3304 −3623 −4328 3747 −3462 −4761 −3953 −4671 −4212 −3320 −3352 −3748−3779 −2839 −2981 −4004 −3668 −4222 653 — −149 −500 233 43 −381 399 106−626 210 −466 −720 275 394 45 96 359 117 −369 −294 −249 — −16 −7108−8150 −894 −1115 −701 −1378 * * 633(L) 2002 −1175 −2785 −2475 −1055−2185 −1898 −221 −2172 2054 −104 −2097 −2542 −1964 −2186 −1458 −1162−325 −1982 −1669 654 — −149 −500 233 43 −381 399 106 −626 210 −466 −720275 394 45 96 359 117 −369 −294 −249 — −16 −7108 −8150 −894 −1115 −701−1378 * * 634(K 943 −1709 −403 133 −2096 781 −142 −1801 994 −1811 −930−144 −1543 292 938 844 −405 −1399 −2023 −1402 655 — −149 −500 233 43−381 399 106 −626 210 −466 −720 275 394 45 96 359 117 −369 −294 −249 —−16 −7108 −8150 −894 −1115 −701 −1378 * * 635(I) 525 −452 −2111 23 −445−1963 −805 1776 −1266 −283 345 −1346 −2019 −1026 −1323 −1017 −436 1518−942 1179 656 — −149 −500 233 43 −381 399 106 −626 210 −466 −720 275 39445 96 359 117 −369 −294 −249 — −16 −7108 −8150 −894 −1115 −701 −1378 * *636(W −1626 −1321 −3570 −3141 2053 −3057 −937 2580 −2760 −226 −54 −2426−2999 −2185 −2514 −2189 −1555 −448 3586 581 657 — −149 −500 233 43 −381399 106 −626 210 −466 −720 275 394 45 96 359 117 −369 −294 −249 — −16−7108 −8150 −894 −1115 −701 −1378 * * 637(D −1498 −3029 3115 17 −3354−1691 −852 −3199 1912 −3109 −2371 −341 −2120 −495 −1230 −1252 −1519−2742 −3208 −2450 658 — −149 −500 233 43 −381 399 106 −626 210 −466 −720275 394 45 96 359 117 −369 −294 −249 — −16 −7108 −8150 −894 −1115 −701−1378 * * 638(W −3358 −2599 −4116 −4259 2442 −3892 −536 −2247 −3821−1683 −1712 −2792 −3835 −2843 −3352 −3227 −3271 −2441 5485 1363 659 —−149 −500 233 43 −381 399 106 −626 210 −466 −720 275 394 45 96 359 117−369 −294 −249 — −16 −7108 −8150 −894 −1115 −701 −1378 * * 639(C 30043179 −3175 −3184 −2750 −1300 −2459 −2082 −2872 −2641 −1933 −1922 −2041−2538 −2722 −657 −796 −1473 −3106 −2895 660 — −149 −500 233 43 −381 399106 −626 210 −466 −720 275 394 45 96 359 117 −369 −294 −249 — −16 −7108−8150 −894 −1115 −701 −1378 * * 640(S) −897 −1462 −2333 −2543 −3185−1640 −2474 −3294 −2686 −3497 −2780 −1973 −2360 −2483 −2703 3465 −1316−2413 −3310 −3025 661 — −149 −500 233 43 −381 399 106 −626 210 −466 −720275 394 45 96 359 117 −369 −294 −249 — −16 −7108 −8150 −894 −1115 −701−1378 * * 641(T) −638 −1323 −1200 −1263 −2717 −1420 −1550 −2421 −1436−2697 −1948 1009 −2035 −1340 −1682 −796 3384 −1817 −2917 −2452 662 —−149 −500 233 43 −381 399 106 −626 210 −466 −720 275 394 45 96 359 117−369 −294 −249 — −16 −7108 −8150 −894 −1115 −701 −1378 * * 642(H −30 43911 363 −394 −739 699 −414 463 −757 501 286 −577 639 165 −23 111 −312 697−25 663 — −149 −500 233 43 −381 399 106 −626 210 −466 −720 275 394 45 96359 117 −369 −294 −249 — −16 −7108 −8150 −894 −1115 −701 −1378 * * 643(D1256 −1810 2828 −193 −2711 −1421 −825 −2377 −710 −2507 −1697 −438 −1858−471 −1243 −735 787 −1875 −2779 −2131 664 — −149 −500 233 43 −381 399106 −626 210 −466 −720 275 394 45 96 359 117 −369 −294 −249 — −16 −7108−8150 −894 −1115 −701 −1378 * * 644(K −1038 −2259 −689 −253 −2738 777−360 −2382 2468 −2269 −1451 −481 −1931 2027 226 −921 −949 −2002 −2343−1850 665 — −149 −500 233 43 −381 398 106 −626 210 −466 −721 276 395 4596 360 118 −369 −294 −249 — −535 −1708 −8150 −140 −3430 −701 −1378 * *645(G −1044 −1813 −773 −1023 −3345 2987 −1699 −3331 −1775 −3418 −26592131 −2239 −1475 −2156 −1127 −1361 −2539 −3373 −2907 667 — −149 −500 23343 −381 399 106 −626 210 −466 −720 275 394 45 96 359 117 −369 −294 −249— −16 −7108 −8150 −894 −1115 −701 −1378 * * 646(E) −488 −1836 1360 1439−2104 −1403 −131 −1820 229 87 −955 −60 −1537 301 −280 469 631 −1431−2061 −1399 668 — −149 −500 233 43 −381 399 106 −626 210 −466 −720 275394 45 96 359 117 −369 −294 −249 — −16 −7108 −8150 −894 −1115 −701−1378 * * 647(E) −1127 −2366 −800 2480 −2838 −1878 −336 −2455 1396 −2301−1488 −522 −1975 95 1670 −993 −1007 −2085 −2343 −1881 669 — −149 −500233 43 −381 399 106 −626 210 −466 −720 275 394 45 96 359 117 −369 −294−249 — −16 −7108 −8150 −894 −1115 −701 −1378 * * 648(P) 955 −915 −2251−2048 −2204 −1361 −1790 −1375 −1894 −1974 −1329 −1523 3265 −1711 −2016−660 −714 631 −2606 −2267 670 — −149 −500 233 43 −381 399 106 −626 210−466 −720 275 394 45 96 359 117 −369 −294 −249 — −16 −7108 −8150 −894−1115 −701 −1378 * * 649(D −1535 −3339 3248 856 −3535 −1586 −853 −3417−967 −3307 −2587 −180 −2074 1731 −1720 −1229 −1578 −2919 −3496 −2555 671— −149 −500 233 43 −381 399 106 −626 210 −466 −720 275 394 45 96 359 117−369 −294 −249 — −16 −7108 −8150 −894 −1115 −701 −1378 * * 650(V −1754−1297 −4329 −3968 −1770 −4053 −3752 2602 −3840 −621 −545 −3728 −3878−3699 −3917 −3370 −1746 2861 −3276 −2829 672 — −149 −500 233 43 −381 399106 −626 210 −466 −720 275 394 45 96 359 117 −369 −294 −249 — −16 −7108−8150 −894 −1115 −701 −1378 * * 651(V −1736 −1298 −4275 −3915 −1733−3969 −3654 1867 −3766 −598 −525 −3663 −3828 −3619 −3833 −3283 −17333222 −3208 −2763 673 — −149 −500 233 43 −381 399 106 −626 210 −466 −720275 394 45 96 359 117 −369 −294 −249 — −16 −7108 −8150 −894 −1115 −701−1378 * * 652(M −2158 −1763 −4466 −3857 2098 −3961 −2711 1339 −3551 21942215 −3609 −3535 −2747 −3220 −3143 −2048 −438 −1879 −1836 674 — −149−500 233 43 −381 399 106 −626 210 −466 −720 275 394 45 96 359 117 −369−294 −249 — −16 −7108 −8150 −894 −1115 −701 −1378 * * 653(A 2500 −821−2504 −2171 −1756 −1515 −1719 −589 −1953 −1465 −872 −1633 −2062 −1734−2039 −780 1073 1394 −2251 −1909 675 — −149 −500 233 43 −381 399 106−626 210 −466 −720 275 394 45 96 359 117 −369 −294 −249 — −16 −7108−8150 −894 −1115 −701 −1378 * * 654(A 2412 −931 −2308 −2228 −3059 1309−2079 −2797 −2207 −3025 −2139 −1529 −1901 −1934 −2326 1722 −691 −1849−3263 −2994 676 — −149 −500 233 43 −381 399 106 −626 210 −466 −720 275394 45 96 359 117 −369 −294 −249 — −16 −7108 −8150 −894 −1115 −701−1378 * * 655(A 2464 −791 −2155 −1787 −1514 −1500 −1408 1386 −1595 −1309−672 −1424 −1982 −1405 −1732 688 −624 −473 −1963 −1596 677 — −149 −500233 43 −381 399 106 −626 210 −466 −720 275 394 45 96 359 117 −369 −294−249 — −16 −7108 −8150 −894 −1115 −701 −1378 * * 656(G −2594 −2690 −3304−3623 −4328 3747 −3462 −4761 −3953 −4671 −4212 −3320 −3352 −3748 −3779−2839 −2981 −4004 −3668 −4222 678 — −149 −500 233 43 −381 399 106 −626210 −466 −720 275 394 45 96 359 117 −369 −294 −249 — −16 −7108 −8150−894 −1115 −701 −1378 * * 657(T) −457 −1344 1397 −166 −1749 −1438 −424−1324 −173 −1546 −757 −384 −1663 −77 −623 628 1799 847 −1920 −1372 679 —−149 −500 233 43 −381 399 106 −626 210 −466 −720 275 394 45 96 359 117−369 −294 −249 — −16 −7108 −8150 −894 −1115 −701 −1378 * * 658(E) −1108−1855 −497 2835 −2161 −1834 −982 −964 −783 −1744 −1237 −739 −2163 −677−1197 −1164 −1148 1427 −2502 −1927 680 — −149 −500 233 43 −381 399 106−626 210 −466 −720 275 394 45 96 359 117 −369 −294 −249 — −16 −7108−8150 −894 −1115 −701 −1378 * * 659(P) −853 −1252 −2460 −2393 −2139−1784 −2109 −974 −2210 −1748 −1364 −1924 3453 −2108 −2271 −1167 −11521448 −2678 −2307 681 — −149 −500 233 43 −381 399 106 −626 210 −466 −720275 394 45 96 359 117 −369 −294 −249 — −16 −7108 −8150 −894 −1115 −701−1378 * * 660(T) −495 −998 −1197 −789 −1334 −1567 −751 −851 −618 −11532261 892 −1849 −564 −910 −695 2581 −648 −1684 −1235 682 — −149 −500 23343 −381 399 106 −626 210 −466 −720 275 394 45 96 359 117 −369 −294 −249— −16 −7108 −8150 −894 −1115 −701 −1378 * * 661(Q −425 −1001 −831 6291174 −1595 −316 −637 −152 579 −150 −476 −1677 1648 −532 −563 735 −470−1354 −875 683 — −149 −500 233 43 −381 399 106 −626 210 −466 −720 275394 45 96 359 117 −369 −294 −249 — −16 −7108 −8150 −894 −1115 −701−1378 * * 662(E) −2641 −3308 −896 3732 −3966 −2458 −2043 −4105 −2128−4016 −3555 −1531 −2959 −1842 −2560 −2479 −2750 −3722 −3563 −3385 684 —−149 −500 233 43 −381 399 106 −626 210 −466 −720 275 394 45 96 359 117−369 −294 −249 — −16 −7108 −8150 −894 −1115 −701 −1378 * * 663(I) 525−535 −2111 −1551 −638 −1888 −920 1560 −1309 −455 170 −1362 −2031 −1084−1399 1061 708 1332 −1134 −763 685 — −149 −500 233 43 −381 399 106 −626210 −466 −720 275 394 45 96 359 117 −369 −294 −249 — −16 −7108 −8150−894 −1115 −701 −1378 * * 664(M −2362 −1913 −4673 −4086 −501 −4285 −30771692 −3808 2336 2939 −3933 −3746 −2955 −3477 −3510 −2250 −300 −2098−2139 686 — −149 −500 233 43 −381 399 106 −626 210 −466 −720 275 394 4596 359 117 −369 −294 −249 — −16 −7108 −8150 −894 −1115 −701 −1378 * *665(A 2734 −1554 −1235 −966 −2607 −1620 −1015 −2163 1487 −2343 −1601−988 −2045 −691 −583 −903 −969 −1725 −2578 −2168 687 — −149 −500 233 43−381 399 106 −626 210 −466 −720 275 394 45 96 359 117 −369 −294 −249 —−16 −7108 −8150 −894 −1115 −701 −1378 * * 666(A 3438 −1472 −2846 −3040−3287 −1726 −2735 −2840 −3028 −3257 −2662 −2236 −2447 −2798 −2944 −1216−1387 −2183 −3405 −3320 688 — −149 −500 233 43 −381 399 106 −626 210−466 −720 275 394 45 96 359 117 −369 −294 −249 — −16 −7108 −8150 −894−1115 −701 −1378 * * 667(I) 1114 −756 −2253 −1864 −1305 −1646 −1394 2517−1656 −1054 −461 −1512 −2066 −1454 −1761 1262 −650 −138 −1806 −1439 689— −149 −500 233 43 −381 399 106 −626 210 −466 −720 275 394 45 96 359 117−369 −294 −249 — −16 −7108 −8150 −894 −1115 −701 −1378 * * 668(D 900−2457 2570 175 −2815 −1502 −553 −2590 −386 −2564 −1737 −168 −1841 2095−969 −821 −1001 −2141 −2768 −2010 690 — −149 −500 233 43 −381 399 106−626 210 −466 −720 275 394 45 96 359 117 −369 −294 −249 — −16 −7108−8150 −894 −1115 −701 −1378 * * 669(I) 292 −707 −2167 −1590 −719 −2180−1027 2540 537 441 146 −1486 −2230 −1118 −1321 −1247 −668 405 −1287 −917691 — −149 −500 233 43 −381 399 106 −626 210 −466 −720 275 394 45 96 359117 −369 −294 −249 — −16 −7108 −8150 −894 −1115 −701 −1378 * * 670(L)−2871 −2457 −4231 −4103 −1033 −3803 −3165 −541 −3734 3130 −31 −3935−3797 −3286 −3484 −3713 −2869 −1136 −2394 −2220 692 — −149 −500 233 43−381 399 106 −626 210 −466 −720 275 394 45 96 359 117 −369 −294 −249 —−16 −7108 −8150 −894 −1115 −701 −1378 * * 671(H −1177 −2326 −1134 −457−2809 −1977 3593 −2401 1445 −2244 −1443 844 −2024 111 1735 −1061 −1033−2058 −2268 −1857 693 — −149 −500 233 43 −381 399 106 −626 210 −466 −720275 394 45 96 359 117 −369 −294 −249 — −16 −7108 −8150 −894 −1115 −701−1378 * * 672(E) 15 −2170 1563 1959 −2472 −1425 −226 −2237 855 −2177−1280 −49 −1617 1268 −431 −502 −609 −1785 −2349 −1631 694 — −149 −500233 43 −381 399 106 −626 210 −466 −720 275 394 45 96 359 117 −369 −294−249 — −16 −7108 −8150 −894 −1115 −701 −1378 * * 673(H −403 −1628 −358195 −1861 −1414 1618 −1548 320 −279 1074 912 −1503 1197 1139 446 −340−1203 −1863 −1247 695 — −149 −500 233 43 −381 399 106 −626 210 −466 −720275 394 45 96 359 117 −369 −294 −249 — −16 −7108 −8150 −894 −1115 −701−1378 * * 674(C −513 2550 −2600 −2019 2246 845 −943 1137 −1680 −244 350−1605 −2090 −1357 −1587 −1083 −488 249 −881 −474 696 — −149 −500 233 43−381 399 106 −626 210 −466 −720 275 394 45 96 359 117 −369 −294 −249 —−340 −7108 −2304 −894 −1115 −701 −1378 * * 675(P) −2312 −2374 −2796−3036 −3591 −2432 −2883 −3881 −3157 −3835 −3473 −2848 4156 −3101 −3072−2546 −2648 −3391 −3143 −3459 697 — −149 −500 233 43 −381 399 106 −626210 −466 −720 275 394 45 96 359 117 −369 −294 −249 — −20 −6788 −7830−894 −1115 −1306 −747 * * 676(E) −985 −2607 1546 2542 −2883 −1323 −441−2699 −378 −2634 −1828 58 −1713 −60 −1032 869 −997 −2229 −2828 −1997 698— −149 −500 233 43 −381 399 106 −626 210 −466 −720 275 394 45 96 359 117−369 −294 −249 — −20 −6788 −7830 −894 −1115 −421 −1984 * * 677(L) −2103−1693 −4449 −3873 −568 −4003 −2874 1606 −3596 2406 2166 −3648 −3596−2862 −3318 −3203 −2010 674 −2059 −2029 699 — −149 −500 233 43 −381 399106 −626 210 −466 −720 275 394 45 96 359 117 −369 −294 −249 — −16 −7108−8150 −894 −1115 −701 −1378 * * 678(K −2059 −2767 −2575 −1375 −3583−2596 −558 −2947 3236 −2620 −1947 −1295 −2560 −141 2026 −1942 −1766−2709 −2469 −2350 700 — −149 −500 233 43 −381 399 106 −626 210 −466 −720275 394 45 96 359 117 −369 −294 −249 — −16 −7108 −8150 −894 −1115 −701−1378 * * 679(I) −1544 −1176 −3965 −3470 1894 −3502 −2556 2750 −3215−120 −27 −3124 −3366 −2846 −3113 −2694 −1504 1816 −2142 −1735 701 — −149−500 233 43 −381 399 106 −626 210 −466 −720 275 394 45 96 359 117 −369−294 −249 — −16 −7108 −8150 −894 −1115 −701 −1378 * * 680(R −2118 −2789−2710 −1441 −3626 −2635 −569 −2972 2088 −2636 −1971 −1337 −2591 −1533343 −2003 −1811 −2743 −2476 −2375 702 — −149 −500 233 43 −381 399 106−626 210 −466 −720 275 394 45 96 359 117 −369 −294 −249 — −16 −7108−8150 −894 −1115 −701 −1378 * * 681(Y −1738 −1421 −3486 −3138 2368 −3054−658 −643 −2769 −827 −509 −2313 −3036 −2175 −2527 −2188 −1672 2239 −692812 703 — −149 −500 233 43 −381 399 106 −626 210 −466 −720 275 394 4596 359 117 −369 −294 −249 — −16 −7108 −8150 −894 −1115 −701 −1378 * *682(V −1754 −1297 −4329 −3968 −1770 −4053 −3752 2614 −3840 −621 −545−3729 −3878 −3699 −3917 −3370 −1746 2852 −3276 −2830 704 — −149 −500 23343 −381 399 106 −626 210 −466 −720 275 394 45 96 359 117 −369 −294 −249— −16 −7108 −8150 −894 −1115 −701 −1378 * * 683(N −2171 −2655 −1458−1748 −3334 −2364 −2267 −3943 −2365 −3936 −3437 4205 −2932 −2205 −2608−2224 −2439 −3392 −3253 −2909 705 — −149 −500 233 43 −381 399 106 −626210 −466 −720 275 394 45 96 359 117 −369 −294 −249 — −16 −7108 −8150−894 −1115 −701 −1378 * * 684(V −1733 −1299 −4267 −3907 −1727 −3955−3640 1809 −3755 −594 −523 −3653 −3820 −3608 −3821 −3270 −1732 3240−3198 −2753 706 — −149 −500 233 43 −381 399 106 −626 210 −466 −720 275394 45 96 359 117 −369 −294 −249 — −16 −7108 −8150 −894 −1115 −701−1378 * * 685(V 484 −646 −2970 −2395 −744 −2499 −1461 1423 −2091 572 130−2055 −2521 −1798 −2031 −1603 1127 2072 −1395 −1034 707 — −149 −500 23343 −381 399 106 −626 210 −466 −720 275 394 45 96 359 117 −369 −294 −249— −16 −7108 −8150 −894 −1115 −701 −1378 * * 686(D −1820 −3681 3540 1270−3878 −1659 −1068 −3841 −1383 −3714 −3101 −268 −2218 −754 −2274 −1465−1906 −3315 −3861 −2859 708 — −149 −500 233 43 −381 399 106 −626 210−466 −720 275 394 45 96 359 117 −369 −294 −249 — −16 −7108 −8150 −894−1115 −701 −1378 * * 687(L) −2374 −1911 −4667 −4149 −624 −4356 −32481959 −3860 2621 550 −4014 −3844 −3100 −3584 −3637 −2284 −16 −2252 −2226709 — −149 −500 233 43 −381 399 106 −626 210 −466 −720 275 394 45 96 359117 −369 −294 −249 — −16 −7108 −8150 −894 −1115 −701 −1378 * * 688(F)−2145 −1754 −4444 −3835 2481 −3940 −2678 1114 −3528 2066 2253 −3582−3521 −2731 −3201 −3119 −2036 −444 −1859 −1796 710 — −149 −500 233 43−381 399 106 −626 210 −466 −720 275 394 45 96 359 117 −369 −294 −249 —−16 −7108 −8150 −894 −1115 −701 −1378 * * 689(K −770 −1778 −879 −243−2063 −1733 −251 850 2294 −1721 −926 −452 −1801 148 1146 500 −677 −1382−1948 −1464 711 — −149 −500 233 43 −381 399 106 −626 210 −466 −720 275394 45 96 359 117 −369 −294 −249 — −16 −7108 −8150 −894 −1115 −701−1378 * * 690(L) −2871 −2457 −4231 −4103 −1033 −3803 −3165 −541 −37343130 −31 −3935 −3797 −3286 −3484 −3713 −2869 −1136 −2394 −2220 712 —−149 −500 233 43 −381 399 106 −626 210 −466 −720 275 394 45 96 359 117−369 −294 −249 — −16 −7108 −8150 −894 −1115 −701 −1378 * * 691(Q −506−1867 −390 1178 −2181 −1467 1538 −1890 436 −1856 1294 −116 −1554 17901511 −401 −435 −1488 −2030 −1407 713 — −149 −500 233 43 −381 399 106−626 210 −466 −720 275 394 45 96 359 117 −369 −294 −249 — −16 −7108−8150 −894 −1115 −701 −1378 * * 692( ) −30 439 11 363 −394 −739 699 −414463 −757 501 286 −577 639 165 −23 111 −312 697 −25 714 — −149 −500 23343 −381 399 106 −626 210 −466 −720 275 394 45 96 359 117 −369 −294 −249— −16 −7108 −8150 −894 −1115 −701 −1378 * * 693(N 911 −1243 −1049 −908−2750 −1283 −1224 −2483 −1070 −2619 −1762 2307 −1836 −911 −1451 2263−707 −1785 −2854 −2361 715 — −149 −500 233 43 −381 399 106 −626 210 −466−720 275 394 45 96 359 117 −369 −294 −249 — −16 −7108 −8150 −894 −1115−701 −1378 * * 694(E) 462 −1884 883 1229 −2200 −1380 −99 −1941 284 −1912−1007 −31 1086 347 −229 391 628 −1510 −2102 −1423 716 — −149 −500 233 43−381 399 106 −626 210 −466 −720 275 394 45 96 359 117 −369 −294 −249 —−16 −7108 −8150 −894 −1115 −701 −1378 * * 695(K 472 −1945 816 942 −2258507 −83 −2010 1429 −1957 −1042 −12 −1504 1244 −204 −340 −412 −1564 −2129−1439 717 — −149 −500 233 43 −381 399 106 −626 210 −466 −720 275 394 4596 359 117 −369 −294 −249 — −16 −7108 −8150 −894 −1115 −701 −1378 * *696(K 725 −1680 −306 1306 355 −1399 −79 −1633 1414 −1671 −800 −73 −1499350 −177 548 −349 −1268 −1917 −1284 718 — −149 −500 233 43 −381 399 106−626 210 −466 −720 275 394 45 96 359 117 −369 −294 −249 — −195 −7108−3069 −894 −1115 −701 −1378 * * 697(H −1103 −2714 2043 320 −2881 −14292588 −2787 −470 −2720 −1925 2549 −1819 −164 −1109 −872 −1112 −2328 −2864−2024 719 — −149 −500 233 43 −381 399 106 −626 210 −466 −720 275 394 4596 359 117 −369 −294 −249 — −18 −6931 −7973 −894 −1115 −1083 −922 * *698(P) −1509 −2622 2222 −258 −3351 −1688 −1206 −3299 −1351 −3294 −2623−586 3242 −916 −1988 −1364 −1649 −2782 −3270 −2663 720 — −149 −500 23343 −381 399 106 −626 210 −466 −720 275 394 45 96 359 117 −369 −294 −249— −18 −6931 −7973 −894 −1115 −505 −1760 * * 699(H −601 −1891 −436 1733−2050 −1535 2121 −1882 387 −1862 −1003 −192 −1631 281 1501 −502 −527−1509 −1978 1072 721 — −149 −500 233 43 −381 399 106 −626 210 −466 −720275 394 45 96 359 117 −369 −294 −249 — −16 −7108 −8150 −894 −1115 −701−1378 * * 700(G 2344 −1041 −2392 −2527 −3249 2572 −2371 −2970 −2636−3255 −2405 −1721 −2031 −2309 −2645 −661 −858 −2002 −3433 −3246 722 —−149 −500 233 43 −381 399 106 −626 210 −466 −720 275 394 45 96 359 117−369 −294 −249 — −16 −7108 −8150 −894 −1115 −701 −1378 * * 701(L) −2642−2168 −4788 −4235 −465 −4513 −3241 96 −3878 2891 2122 −4166 −3888 −3023−3544 −3807 −2521 −607 −2140 −2183 723 — −149 −500 233 43 −381 399 106−626 210 −466 −720 275 394 45 96 359 117 −369 −294 −249 — −16 −7108−8150 −894 −1115 −701 −1378 * * 702(S) −532 −1511 −753 −320 −2262 −1447−524 −1930 1366 −2008 −1173 −494 −1732 −137 −413 1983 1524 −1495 −2248−1710 724 — −149 −500 233 43 −381 399 106 −626 210 −466 −720 275 394 4596 359 117 −369 −294 −249 — −16 −7108 −8150 −894 −1115 −701 −1378 * *703(D −1718 −3250 3403 −27 −3066 −1736 2667 −3486 −1211 −3381 −2732 −400−2240 −752 −1917 −1439 −1784 −3023 −3204 −2299 725 — −149 −500 233 43−381 399 106 −626 210 −466 −720 275 394 45 96 359 117 −369 −294 −249 —−16 −7108 −8150 −894 −1115 −701 −1378 * * 704(E) 1165 −2746 1435 2588−3046 −1525 −639 −2845 −567 −2796 −1988 −154 −1909 −258 −1213 −943 −1174−2380 −2996 −2179 726 — −149 −500 233 43 −381 399 106 −626 210 −466 −720275 394 45 96 359 117 −369 −294 −249 — −16 −7108 −8150 −894 −1115 −701−1378 * * 705(E) 921 −2774 1237 2767 −3077 −1530 −662 −2877 −603 −2830−2029 −161 −1924 −284 −1256 −967 −1205 −2412 −3032 −2209 727 — −149 −500233 43 −381 399 106 −626 210 −466 −720 275 394 45 96 359 117 −369 −294−249 — −16 −7108 −8150 −894 −1115 −701 −1378 * * 706(F) −3342 −2776−4026 −4232 4354 −3545 −1431 −2315 −4038 −1801 −1900 −3299 −3780 −3350−3645 −3490 −3420 −2566 −739 349 728 — −149 −500 233 43 −381 399 106−626 210 −466 −720 275 394 45 96 359 117 −369 −294 −249 — −16 −7108−8150 −894 −1115 −701 −1378 * * 707(D 1198 −2653 2928 116 −3164 −1523−794 −2975 −806 −2952 −2173 1307 −1973 −435 −1474 −1014 −1273 −2473−3161 −2340 729 — −149 −500 233 43 −381 399 106 −626 210 −466 −720 275394 45 96 359 117 −369 −294 −249 — −16 −7108 −8150 −894 −1115 −701−1378 * * 708(N 497 −2045 1492 265 −2357 −1412 1608 −2108 128 −2074−1183 1928 −1592 229 −403 517 −553 −1673 −2265 −1565 730 — −149 −500 23343 −381 399 106 −626 210 −466 −720 275 394 45 96 359 117 −369 −294 −249— −16 −7108 −8150 −894 −1115 −701 −1378 * * 709(Y −1550 −1282 −3519−3004 −2 −3093 −1385 1232 −2635 1579 299 −2537 −2990 −2153 −2464 −2220−1477 −195 −891 3290 731 — −149 −500 233 43 −381 399 106 −626 210 −466−720 275 394 45 96 359 117 −369 −294 −249 — −16 −7108 −8150 −894 −1115−701 −1378 * * 710(F) −3342 −2776 −4026 −4232 4354 −3545 −1431 −2315−4038 −1801 −1900 −3299 −3780 −3350 −3645 −3490 −3420 −2566 −739 349 732— −149 −500 233 43 −381 399 106 −626 210 −466 −720 275 394 45 96 359 117−369 −294 −249 — −16 −7108 −8150 −894 −1115 −701 −1378 * * 711(T) −1213−1674 −2755 −2906 −3163 −1922 −2659 −2698 −2788 −3105 −2612 −2311 −2600−2708 −2753 −1463 3819 −2197 −3286 −3156 733 — −149 −500 233 43 −381 399106 −626 210 −466 −720 275 394 45 96 359 117 −369 −294 −249 — −16 −7108−8150 −894 −1115 −701 −1378 * * 712(K 921 −1810 −280 1204 −2126 −1422−125 −1835 1451 −1838 −956 −97 −1544 311 −168 −386 1295 −1438 −2048−1407 734 — −149 −500 233 43 −381 399 106 −626 210 −466 −720 275 394 4596 359 117 −369 −294 −249 — −16 −7108 −8150 −894 −1115 −701 −1378 * *713(D −2784 −3432 4016 −1200 −4140 −2466 −2197 −4505 −2621 −4365 −3956−1551 −3014 −2039 −3232 −2593 −2938 −4046 −3710 −3552 735 — −149 −500233 43 −381 399 106 −626 210 −466 −720 275 394 45 96 359 117 −369 −294−249 — −16 −7108 −8150 −894 −1115 −701 −1378 * * 714(K −1441 −2413 −1657−802 −3025 −2193 −410 −2523 2846 −2335 −1581 −885 −2213 14 1863 −1343790 −2218 −2320 −2022 736 — −149 −500 233 43 −381 399 106 −626 210 −466−720 275 394 45 96 359 117 −369 −294 −249 — −16 −7108 −8150 −894 −1115−701 −1378 * * 715(P) −540 −1180 −1850 −1974 −3103 −1352 −2072 −2962−2149 −3170 −2355 −1527 3509 −1943 −2279 1382 −938 −2068 −3276 −2949 737— −149 −500 233 43 −381 399 106 −626 210 −466 −720 275 394 45 96 359 117−369 −294 −249 — −16 −7108 −8150 −894 −1115 −701 −1378 * * 716(V −1751−1297 −4323 −3962 −1768 −4044 −3741 2446 −3832 −620 −545 −3721 −3872−3691 −3908 −3361 −1744 2965 −3270 −2823 738 — −149 −500 233 43 −381 399106 −626 210 −466 −720 275 394 45 96 359 117 −369 −294 −249 — −16 −7108−8150 −894 −1115 −701 −1378 * * 717(H −792 −632 −2808 −2210 −439 −23602159 1209 −1870 1529 409 −1883 −2368 −1554 −1794 −1446 −733 1579 −1121−776 739 — −149 −500 233 43 −381 399 106 −626 210 −466 −720 275 394 4596 359 117 −369 −294 −249 — −16 −7108 −8150 −894 −1115 −701 −1378 * *718(F) −3342 −2776 −4026 −4232 4354 −3545 −1431 −2315 −4038 −1801 −1900−3299 −3780 −3350 −3645 −3490 −3420 −2566 −739 349 740 — −149 −500 23343 −381 399 106 −626 210 −466 −720 275 394 45 96 359 117 −369 −294 −249— −16 −7108 −8150 −894 −1115 −701 −1378 * * 719(A 2895 −1250 −1253 −1325−2863 −1348 −1637 −2577 −1616 −2833 −2042 1775 −1991 −1424 −1888 −716−888 −1873 −3053 −2611 741 — −149 −500 233 43 −381 399 106 −626 210 −466−720 275 394 45 96 359 117 −369 −294 −249 — −16 −7108 −8150 −894 −1115−701 −1378 * * 720(Y −3687 −2724 −4232 −4508 3154 −4089 −368 −2628 −4071−2023 −2062 −2751 −3956 −2869 −3483 −3324 −3551 −2761 3099 3684 742 —−149 −500 233 43 −381 399 106 −626 210 −466 −720 275 394 45 96 359 117−369 −294 −249 — −16 −7108 −8150 −894 −1115 −701 −1378 * * 721(H −3205−3079 −2723 −2890 −2110 −3046 5295 −4135 −2617 −3813 −3561 −2886 −3482−2833 −2620 −3291 −3356 −3895 −2397 −1681 743 — −149 −500 233 43 −381399 106 −626 210 −466 −720 275 394 45 96 359 117 −369 −294 −249 — −16−7108 −8150 −894 −1115 −701 −1378 * * 722(G −459 −1100 −1991 −2176 −32993009 −2249 −3146 −2470 −3360 −2491 −1586 −2028 −2146 −2555 1630 −885−2108 −3464 −3207 744 — −149 −500 233 43 −381 399 106 −626 210 −466 −720275 394 45 96 359 117 −369 −294 −249 — −16 −7108 −8150 −894 −1115 −701−1378 * * 723(Y −3590 −2700 −4146 −4380 2110 −4028 −403 −2517 −3963−1928 −1973 −2744 −3921 −2844 −3431 −3284 −3474 −2669 338 4419 745 —−149 −500 233 43 −381 399 106 −626 210 −466 −720 275 394 45 96 359 117−369 −294 −249 — −16 −7108 −8150 −894 −1115 −701 −1378 * * 724(E) 930−1529 −450 1712 −1762 −1469 −180 −1376 198 −1516 −699 −206 −1582 213 806−430 −409 672 −1834 −1256 746 — −149 −500 233 43 −381 399 106 −626 210−466 −720 275 394 45 96 359 117 −369 −294 −249 — −16 −7108 −8150 −894−1115 −701 −1378 * * 725(D −696 −2211 2006 276 −2503 −1435 1781 −2271 47−2216 −1327 1502 621 1163 −498 −540 −655 −1822 −2394 −1669 747 — −149−500 233 43 −381 399 106 −626 210 −466 −720 275 394 45 96 359 117 −369−294 −249 — −16 −7108 −8150 −894 −1115 −701 −1378 * * 726(M −522 −14631325 1144 −1558 −1519 −266 −1159 3 493 2326 −260 −1645 90 −458 −522 −468−941 −1762 −1204 748 — −149 −500 233 43 −381 399 106 −626 210 −466 −720275 394 45 96 359 117 −369 −294 −249 — −16 −7108 −8150 −894 −1115 −701−1378 * * 727(I) −1755 −1312 −4289 −3853 −1390 −3961 −3331 2559 −36771028 −208 −3600 −3736 −3367 −3647 −3222 −1724 2382 −2800 −2488 749 —−149 −500 233 43 −381 399 106 −626 210 −466 −720 275 394 45 96 359 117−369 −294 −249 — −16 −7108 −8150 −894 −1115 −701 −1378 * * 728(Q −1019−2299 −664 1508 −2732 −1794 −307 −2378 502 −2248 −1420 −437 −1902 23052189 −887 −914 −1997 −2316 −1812 750 — −149 −500 233 43 −381 399 106−626 210 −466 −720 275 394 45 96 359 117 −369 −294 −249 — −16 −7108−8150 −894 −1115 −701 −1378 * * 729(G 676 −1581 1006 −319 −2686 1982−822 −2430 −639 −2491 −1630 −507 −1785 −454 −1135 1417 −738 −1837 −2718−2108 751 — −149 −500 233 43 −381 399 106 −626 210 −466 −720 275 394 4596 359 117 −369 −294 −249 — −16 −7108 −8150 −894 −1115 −701 −1378 * *730(L) −2364 −1901 −4660 −4144 −630 −4349 −3246 2015 −3856 2597 544−4006 −3841 −3101 −3583 −3629 −2275 2 −2255 −2227 752 — −149 −500 233 43−381 399 106 −626 210 −466 −720 275 394 45 96 359 117 −369 −294 −249 —−16 −7108 −8150 −894 −1115 −701 −1378 * * 731(F) −2056 −1668 −4299 −37523006 −3840 −2396 1861 −3446 1502 554 −3415 −3499 −2733 −3168 −3023 −1964−161 −1660 −1259 753 — −149 −500 233 43 −381 399 106 −626 210 −466 −720275 394 45 96 359 117 −369 −294 −249 — −16 −7108 −8150 −894 −1115 −701−1378 * * 732(F) −3581 −2688 −4165 −4401 3865 −4034 −401 −2491 −3981−1903 −1944 −2746 −3921 −2847 −3438 −3284 −3462 −2647 341 3054 754 —−149 −500 233 43 −381 399 106 −626 210 −466 −720 275 394 45 96 359 117−369 −294 −249 — −16 −7108 −8150 −894 −1115 −701 −1378 * * 733(D −1066−2664 2593 230 −2949 899 −545 −2751 996 −2680 −1846 1209 −1852 −148−1001 −857 −1060 −2284 −2863 −2068 755 — −149 −500 233 43 −381 399 106−626 210 −466 −720 275 394 45 96 359 117 −369 −294 −249 — −16 −7108−8150 −894 −1115 −701 −1378 * * 734(R −2957 −3022 −3318 −2735 −3796−2998 −1968 −3912 −846 −3631 −3157 −2611 −3280 −1724 4056 −3026 −2913−3650 −3096 −3185 756 — −149 −500 233 43 −381 399 106 −626 210 −466 −720275 394 45 96 359 117 −369 −294 −249 — −16 −7108 −8150 −894 −1115 −701−1378 * * 735(H 673 −1400 −855 −643 −2108 −1470 3344 −1923 −596 −2073−1302 −744 2404 −583 −931 −699 −761 −1503 −2291 −1733 757 — −149 −500233 43 −381 399 106 −626 210 −466 −720 275 394 45 96 359 117 −369 −294−249 — −16 −7108 −8150 −894 −1115 −701 −1378 * * 736(N −1426 −2353 −948−735 −2920 −1991 −796 −2769 68 −2666 −1942 3441 −2268 −432 1742 −1361−1415 −2383 −2592 −2147 758 — −149 −500 233 43 −381 399 106 −626 210−466 −720 275 394 45 96 359 117 −369 −294 −249 — −16 −7108 −8150 −894−1115 −701 −1378 * * 737(H −1168 −1729 −1567 −889 −1360 −2118 3917 −1446284 543 −865 −957 −2175 −247 1258 −1239 −1055 −1304 −1577 −976 759 —−149 −500 233 43 −381 399 106 −626 210 −466 −720 275 394 45 96 359 117−369 −294 −249 — −16 −7108 −8150 −894 −1115 −701 −1378 * * 738(D −1353−3032 2615 202 −3188 −1564 2079 −3118 −756 −3034 −2267 2486 −1998 −383−1443 −1092 −1377 −2642 −3178 −2294 760 — −149 −500 233 43 −381 399 106−626 210 −466 −720 275 394 45 96 359 117 −369 −294 −249 — −812 −7108−1241 −894 −1115 −701 −1378 * * 739(N −667 −1675 −384 −20 −2103 −1394−82 −1850 715 −1813 −1049 2293 −1591 303 2121 −603 −621 −1504 −1871−1383 761 — −149 −500 233 43 −381 399 106 −626 210 −466 −720 275 394 4596 359 117 −369 −294 −249 — −27 −6323 −7365 −894 −1115 −292 −2448 * *740(F) 835 −719 −3036 −2438 1835 −2475 −1354 332 −2101 1627 473 −2059−2472 −1719 −1973 −1574 −844 1081 −1167 −839 762 — −149 −500 233 43 −381399 106 −626 210 −466 −720 275 394 45 96 359 117 −369 −294 −249 — −16−7108 −8150 −894 −1115 −701 −1378 * * 741(H 501 −1345 −519 3 −1474 −14782277 −1148 102 −1306 −513 945 −1582 159 −343 −433 1418 −890 −1646 876763 — −149 −500 233 43 −381 399 106 −626 210 −466 −720 275 394 45 96 359117 −369 −294 −249 — −16 −7108 −8150 −894 −1115 −701 −1378 * * 742(V−1752 −1297 −4324 −3962 −1768 −4045 −3742 2459 −3833 −621 −545 −3722−3873 −3691 −3909 −3362 −1744 2956 −3271 −2823 764 — −149 −500 233 43−381 399 106 −626 210 −466 −720 275 394 45 96 359 117 −369 −294 −249 —−16 −7108 −8150 −894 −1115 −701 −1378 * * 743( ) −30 439 11 363 −394−739 699 −414 463 −757 501 286 −577 639 165 −23 111 −312 697 −25 765 —−149 −500 233 43 −381 399 106 −626 210 −466 −720 275 394 45 96 359 117−369 −294 −249 — −16 −7108 −8150 −894 −1115 −701 −1378 * * 744(H −991−1830 −1052 −504 −1930 −1886 3890 −1681 1542 −1767 −1038 −666 −1989 −60176 −985 −903 206 −1921 −1408 766 — −149 −500 233 43 −381 399 106 −626210 −466 −720 275 394 45 96 359 117 −369 −294 −249 — −16 −7108 −8150−894 −1115 −701 −1378 * * 745(G −494 −1130 −1974 −2194 −3326 3228 −2287−3191 −2529 −3407 −2546 −1609 −2055 −2198 −2601 938 −923 −2148 −3486−3235 767 — −149 −500 233 43 −381 399 106 −626 210 −466 −720 275 394 4596 359 117 −369 −294 −249 — −16 −7108 −8150 −894 −1115 −701 −1378 * *746(Y −3482 −2868 −3701 −3919 238 −3552 −1112 −3000 −3638 −2516 −2526−3027 −3772 −3101 −3341 −3418 −3527 −3071 −441 4711 768 — −149 −500 23343 −381 399 106 −626 210 −466 −720 275 394 45 96 359 117 −369 −294 −249— −16 −7108 −8150 −894 −1115 −701 −1378 * * 747(R −1317 −2448 −1232 1501−3004 −2062 −362 −2555 2088 −2353 −1567 −710 −2107 70 2409 −1189 −1156−2213 −2342 −1973 769 — −149 −500 233 43 −381 399 106 −626 210 −466 −720275 394 45 96 359 117 −369 −294 −249 — −16 −7108 −8150 −894 −1115 −701−1378 * * 748(E) −2641 −3308 −896 3732 −3966 −2458 −2043 −4105 −2128−4016 −3555 −1531 −2959 −1842 −2560 −2479 −2750 −3722 −3563 −3385 770 —−149 −500 233 43 −381 399 106 −626 210 −466 −720 275 394 45 96 359 117−369 −294 −249 — −16 −7108 −8150 −894 −1115 −701 −1378 * * 749(E) −603−2088 932 1740 −2382 −1414 −194 −2138 145 −2093 −1197 1660 −1589 1157−389 −462 −556 226 −2276 −1569 771 — −149 −500 233 43 −381 399 106 −626210 −466 −720 275 394 45 96 359 117 −369 −294 −249 — −16 −7108 −8150−894 −1115 −701 −1378 * * 750(G −2594 −2690 −3304 −3623 −4328 3747 −3462−4761 −3953 −4671 −4212 −3320 −3352 −3748 −3779 −2839 −2981 −4004 −3668−4222 772 — −149 −500 233 43 −381 399 106 −626 210 −466 −720 275 394 4596 359 117 −369 −294 −249 — −16 −7108 −8150 −894 −1115 −701 −1378 * *751(D −1242 −2482 2856 −92 −3324 −1544 −1056 −3220 −1180 −3222 −2479−411 −2078 −735 −1856 2119 −1401 −2625 −3370 −2572 773 — −149 −500 23343 −381 399 106 −626 210 −466 −720 275 394 45 96 359 117 −369 −294 −249— −16 −7108 −8150 −894 −1115 −701 −1378 * * 752(I) −1125 −1077 −3099−2749 −1383 −2564 −2209 2720 −2446 −620 −388 −2395 −2828 −2300 −2481−1819 2258 661 −2292 −1909 774 — −149 −500 233 43 −381 399 106 −626 210−466 −720 275 394 45 96 359 117 −369 −294 −249 — −16 −7108 −8150 −894−1115 −701 −1378 * * 753(T) −1213 −1674 −2755 −2906 −3163 −1922 −2659−2698 −2788 −3105 −2612 −2311 −2600 −2708 −2753 −1463 3819 −2197 −3286−3156 775 — −149 −500 233 43 −381 399 106 −626 210 −466 −720 275 394 4596 359 117 −369 −294 −249 — −16 −7108 −8150 −894 −1115 −701 −1378 * *754(T) −1213 −1674 −2755 −2906 −3163 −1922 −2659 −2698 −2788 −3105 −2612−2311 −2600 −2708 −2753 −1463 3819 −2197 −3286 −3156 776 — −149 −500 23343 −381 399 106 −626 210 −466 −720 275 394 45 96 359 117 −369 −294 −249— −16 −7108 −8150 −894 −1115 −701 −1378 * * 755(P) −2931 −2878 −3420−3706 −4181 −2925 −3468 −4621 −3859 −4490 −4165 −3491 4225 −3781 −3695−3182 −3279 −4087 −3594 −4064 777 — −149 −500 233 43 −381 399 106 −626210 −466 −720 275 394 45 96 359 117 −369 −294 −249 — −16 −7108 −8150−894 −1115 −701 −1378 * * 756(F) −3533 −2667 −4143 −4362 4034 −4011 −413−2435 −3947 −1856 −1895 −2743 −3904 −2837 −3418 −3264 −3419 −2596 3272564 778 — −149 −500 233 43 −381 399 106 −626 210 −466 −720 275 394 4596 359 117 −369 −294 −249 — −16 −7108 −8150 −894 −1115 −701 −1378 * *757(D −2784 −3432 4016 −1200 −4140 −2466 −2197 −4505 −2621 −4365 −3956−1551 −3014 −2039 −3232 −2593 −2938 −4046 −3710 −3552 779 — −149 −500233 43 −381 399 106 −626 210 −466 −720 275 394 45 96 359 117 −369 −294−249 — −16 −7108 −8150 −894 −1115 −701 −1378 * * 758(M −1664 −1479 −3731−3304 −822 −3209 −2514 381 −2903 307 4447 −2987 −3235 −2579 −2815 −2469−1688 1155 −2108 −1854 780 — −149 −500 233 43 −381 399 106 −626 210 −466−720 275 394 45 96 359 117 −369 −294 −249 — −16 −7108 −8150 −894 −1115−701 −1378 * * 759(R −841 −995 −1971 −1321 −932 −2129 −856 −136 −533−467 2304 −1291 −2194 −758 2401 −1211 −783 1416 −1446 −1079 781 — −149−500 233 43 −381 399 106 −626 210 −466 −720 275 394 45 96 359 117 −369−294 −249 — −16 −7108 −8150 −894 −1115 −701 −1378 * * 760(V −954 −916−2489 −1863 −806 −2402 −1212 292 −1157 906 98 −1725 −2437 −1258 1435−1506 −901 2327 −1472 −1115 782 — −149 −500 233 43 −381 399 106 −626 210−466 −720 275 394 45 96 359 117 −369 −294 −249 — −16 −7108 −8150 −894−1115 −701 −1378 * * 761(V −1831 −1468 −4142 −3585 −674 −3694 −2641 526−3292 1920 2093 −3318 −3425 −2728 −3099 −2876 −1760 2327 −2028 −1893 783— −149 −500 233 43 −381 399 106 −626 210 −466 −720 275 394 45 96 359 117−369 −294 −249 — −16 −7108 −8150 −894 −1115 −701 −1378 * * 762(N −2171−2655 −1458 −1748 −3334 −2364 −2267 −3943 −2365 −3936 −3437 4205 −2932−2205 −2608 −2224 −2439 −3392 −3253 −2909 784 — −149 −500 233 43 −381399 106 −626 210 −466 −720 275 394 45 96 359 117 −369 −294 −249 — −16−7108 −8150 −894 −1115 −701 −1378 * * 763(E) −447 −1916 638 1762 −2239−1385 1510 −1986 1083 −1928 −1009 −19 −1493 1244 466 −323 −386 −1540−2092 −1413 785 — −149 −500 233 43 −381 399 106 −626 210 −466 −720 275394 45 96 359 117 −369 −294 −249 — −16 −7108 −8150 −894 −1115 −701−1378 * * 764(M −1749 −1382 −4134 −3576 −706 −3632 −2595 1821 −3291 17052738 −3271 −3384 −2732 −3086 −2809 −1680 1590 −2012 −1860 786 — −149−500 233 43 −381 399 106 −626 210 −466 −720 275 394 45 96 359 117 −369−294 −249 — −16 −7108 −8150 −894 −1115 −701 −1378 * * 765(D −1369 −26743374 −58 −3453 −1571 −1095 −3380 −1289 −3368 −2659 −394 −2124 −784 −20161149 −1529 −2785 −3505 −2662 787 — −149 −500 233 43 −381 399 106 −626210 −466 −720 275 394 45 96 359 117 −369 −294 −249 — −16 −7108 −8150−894 −1115 −701 −1378 * * 766(R −2957 −3022 −3318 −2735 −3796 −2998−1968 −3912 −846 −3631 −3157 −2611 −3280 −1724 4056 −3026 −2913 −3650−3096 −3185 788 — −149 −500 233 43 −381 399 106 −626 210 −466 −720 275394 45 96 359 117 −369 −294 −249 — −16 −7108 −8150 −894 −1115 −701−1378 * * 767(Y −3616 −2704 −4178 −4426 3471 −4049 −394 −2531 −4004−1934 −1979 −2749 −3932 −2854 −3451 −3298 −3493 −2683 349 3677 789 —−149 −500 233 43 −381 399 106 −626 210 −466 −720 275 394 45 96 359 117−369 −294 −249 — −16 −7108 −8150 −894 −1115 −701 −1378 * * 768(H 274−2294 1079 1119 −2578 −1451 3282 −2348 −50 −2296 −1419 1227 −1687 101−610 −606 −736 −1901 −2481 −1745 790 — −149 −500 233 43 −381 399 106−626 210 −466 −720 275 394 45 96 359 117 −369 −294 −249 — −16 −7108−8150 −894 −1115 −701 −1378 * * 769(L) −2092 −1719 −4323 −3846 −712−3925 −2989 451 −3531 2641 428 −3624 −3640 −2952 −3339 −3191 −2044 1542−2221 −2096 791 — −149 −500 233 43 −381 399 106 −626 210 −466 −720 275394 45 96 359 117 −369 −294 −249 — −16 −7108 −8150 −894 −1115 −701−1378 * * 770(A 2058 −944 −1182 −683 −1304 −1522 −653 −783 −528 −1127−414 −754 −1773 942 −860 −602 852 724 −1630 −1185 792 — −149 −500 233 43−381 399 106 −626 210 −466 −720 275 394 45 96 359 117 −369 −294 −249 —−16 −7108 −8150 −894 −1115 −701 −1378 * * 771(K 1238 −1887 −1224 −813−2786 −1805 −755 −2335 3008 −2384 −1637 −897 −2102 −378 −48 −1055 −1089−1935 −2512 −2122 793 — −149 −500 233 43 −381 399 106 −626 210 −466 −720275 394 45 96 359 117 −369 −294 −249 — −169 −7108 −3273 −894 −1115 −701−1378 * * 772(A 1327 −1917 950 1094 −2220 −1330 −74 −1968 946 −1930−1028 32 −1480 369 −228 547 −411 −1533 −2115 −1424 794 — −149 −500 23343 −381 399 106 −626 210 −466 −720 275 394 45 96 359 117 −369 −294 −249— −17 −6956 −7998 −894 −1115 −1036 −964 * * 773(A 3386 −1299 −2601 −2766−3046 −1559 −2499 −2553 −2749 −2990 −2405 −2021 −2272 −2539 −2697 −1037−1201 −1940 −3200 −3073 795 — −149 −500 233 43 −381 399 106 −626 210−466 −720 275 394 45 96 359 117 −369 −294 −249 — −17 −6956 −7998 −894−1115 −525 −1714 * * 774(I) −1087 −861 −3107 161 −882 −2803 −1771 2342−2281 1091 78 −2300 −2777 −2009 −2269 −1916 −1039 1702 −1691 −1345 796 —−149 −500 233 43 −381 399 106 −626 210 −466 −720 275 394 45 96 359 117−369 −294 −249 — −16 −7108 −8150 −894 −1115 −701 −1378 * * 775(Q 375−1755 −273 815 −2036 −1376 −39 −1756 367 −1753 −857 1007 −1469 1244 843−290 959 12 −1964 −1309 797 — −149 −500 233 43 −381 399 106 −626 210−466 −720 275 394 45 96 359 117 −369 −294 −249 — −16 −7108 −8150 −894−1115 −701 −1378 * * 776(M 1052 −610 −1546 −994 −696 582 −640 −244 −804810 1789 −967 −1833 −639 −1021 395 −384 −113 −1120 −726 798 — −149 −500233 43 −381 399 106 −626 210 −466 −720 275 394 45 96 359 117 −369 −294−249 — −16 −7108 −8150 −894 −1115 −701 −1378 * * 777(I) −416 −776 −1113474 −802 469 −424 1231 −400 255 48 −674 −1747 951 −718 −659 −357 665−1177 −745 799 — −149 −500 233 43 −381 399 106 −626 210 −466 −720 275394 45 96 359 117 −369 −294 −249 — −16 −7108 −8150 −894 −1115 −701−1378 * * 778(D 1034 −2035 2294 −106 −2869 −1459 −830 −2614 −751 −2671−1863 −387 2260 −474 −1320 −825 −1014 −2092 −2906 −2215 800 — −149 −500233 43 −381 399 106 −626 210 −466 −720 275 394 45 96 359 117 −369 −294−249 — −16 −7108 −8150 −894 −1115 −701 −1378 * * 779(A 1299 −1548 −409909 −1800 43 −141 −1467 231 −1558 −718 −156 −1540 264 1153 −374 −369 158−1848 −1253 801 — −149 −500 233 43 −381 399 106 −626 210 −466 −720 275394 45 96 359 117 −369 −294 −249 — −1040 −7108 −981 −894 −1115 −701−1378 * * 780(F) −585 −915 −883 −659 2573 −1541 −52 −591 −624 −695 −2331803 −1767 −468 −869 −739 −609 −487 −70 917 802 — −149 −500 233 43 −381399 106 −626 210 −466 −720 275 394 45 96 359 117 −369 −294 −249 — −424−6099 −2060 −894 −1115 −1914 −445 * * 781(N −313 −1042 254 152 −1409−814 −286 −1511 −122 −1692 −1083 3011 −1287 −82 −434 −340 −474 −1140−1574 −976 803 — −149 −500 233 43 −381 399 106 −626 210 −466 −720 275394 45 96 359 117 −369 −294 −249 — −41 −5717 −6759 −894 −1115 −2091−386 * * 782(E) −647 −1563 589 2680 −1901 −941 −188 −1630 4 −1762 −1176156 −1345 101 −395 −544 −693 −1348 −1863 −1374 804 — −149 −500 233 43−381 399 106 −626 210 −466 −720 275 394 45 96 359 117 −369 −294 −249 —−41 −5717 −6759 −894 −1115 −2091 −386 * * 783(K −682 −1365 −434 −118−1773 −1231 −19 −1449 2744 −1499 −893 −244 −1470 310 740 −670 −643 −1208−1538 −1198 805 — −149 −500 233 43 −381 399 106 −626 210 −466 −720 275394 45 96 359 117 −369 −294 −249 — −41 −5717 −6759 −894 −1115 −612−1532 * * 784(Y −620 −433 −2763 −2164 −265 −2214 −1076 1484 −1822 1442036 −1779 −2223 −1475 −1707 −1306 −562 1635 −935 2216 806 — −149 −500233 43 −381 399 106 −626 210 −466 −720 275 394 45 96 359 117 −369 −294−249 — −20 −6788 −7830 −894 −1115 −1306 −747 * * 785(K −540 −1908 −2861554 −2271 235 −21 −1969 1597 −1892 −1016 −65 −1527 423 1275 −418 −461−1559 −2023 −1427 807 — −149 −500 233 43 −381 399 106 −626 210 −466 −720275 394 45 96 359 117 −369 −294 −249 — −20 −6788 −7830 −894 −1115 −421−1984 * * 786(D −495 −1834 1772 243 −2095 −1409 −135 −1811 226 93 −952959 −1543 1255 −279 −392 713 −1426 −2056 −1398 808 — −149 −500 233 43−381 399 106 −626 210 −466 −720 275 394 45 96 359 117 −369 −294 −249 —−16 −7108 −8150 −894 −1115 −701 −1378 * * 787(K −1474 −2433 −1703 −833−3058 −2216 −418 −2547 2890 −2352 −1602 −908 −2233 6 1874 −1375 633−2246 −2329 −2042 809 — −149 −500 233 43 −381 399 106 −626 210 −466 −720275 394 45 96 359 117 −369 −294 −249 — −16 −7108 −8150 −894 −1115 −701−1378 * * 788(H −451 −1596 −374 131 −1721 4 2032 −1490 223 −1570 −735−150 −1554 1294 −242 993 −394 −1170 −1803 1657 810 — −149 −500 233 43−381 399 106 −626 210 −466 −720 275 394 45 96 359 117 −369 −294 −249 —−16 −7108 −8150 −894 −1115 −701 −1378 * * 789(A 2417 −1302 −925 −642−2356 −1358 −885 −2038 −600 −2179 −1358 −718 −1792 1772 −969 686 −646−1531 −2461 −1952 811 — −149 −500 233 43 −381 399 106 −626 210 −466 −720275 394 45 96 359 117 −369 −294 −249 — −16 −7108 −8150 −894 −1115 −701−1378 * * 790(E) 1699 −2717 1896 1966 −3018 −1521 −628 −2814 −547 −2768−1958 −152 −1900 −245 −1190 −928 −1153 −2352 −2970 −2159 812 — −149 −500233 43 −381 399 106 −626 210 −466 −720 275 394 45 96 359 117 −369 −294−249 — −16 −7108 −8150 −894 −1115 −701 −1378 * * 791(F) −576 −843 −135118 2111 −1835 −543 −341 927 1121 58 −880 −1903 −468 −730 −859 −511 −255−1145 −680 813 — −149 −500 233 43 −381 399 106 −626 210 −466 −720 275394 45 96 359 117 −369 −294 −249 — −16 −7108 −8150 −894 −1115 −701−1378 * * 792(C −1112 2697 −3476 −2950 −1103 −2900 −2047 2026 −2659 −523−143 −2556 −2914 −2378 −2583 −2056 623 2331 −1900 −1524 814 — −149 −500233 43 −381 399 106 −626 210 −466 −720 275 394 45 96 359 117 −369 −294−249 — −16 −7108 −8150 −894 −1115 −701 −1378 * * 793(Q 419 −1959 511 264−2287 −1397 −160 −2033 201 −2001 −1102 892 −1555 2127 −318 1297 −485−1597 −2190 −1503 815 — −149 −500 233 43 −381 399 106 −626 210 −466 −720275 394 45 96 359 117 −369 −294 −249 — −16 −7108 −8150 −894 −1115 −701−1378 * * 794( ) −30 439 11 363 −394 −739 699 −414 463 −757 501 286 −577639 165 −23 111 −312 697 −25 816 — −149 −500 233 43 −381 399 106 −626210 −466 −720 275 394 45 96 359 117 −369 −294 −249 — −16 −7108 −8150−894 −1115 −701 −1378 * * 795(E) −617 −2049 −177 2132 −2369 −1467 1606−2104 1334 −2049 −1159 −104 −1611 267 −171 468 −558 −1677 −2212 −1550817 — −149 −500 233 43 −381 399 106 −626 210 −466 −720 275 394 45 96 359117 −369 −294 −249 — −16 −7108 −8150 −894 −1115 −701 −1378 * * 796(M−2288 −1880 −4481 −3899 1874 −4066 −2635 72 −3594 1748 3848 −3656 −3608−2775 −3272 −3259 −2174 −566 −1778 −1555 818 — −149 −500 233 43 −381 399106 −626 210 −466 −720 275 394 45 96 359 117 −369 −294 −249 — −16 −7108−8150 −894 −1115 −701 −1378 * * 797(D −1194 −2847 2837 1238 −3100 −1527−634 −2920 −571 −2845 −2036 1124 −1913 −251 −1231 −958 827 −2447 −3037−2200 819 — −149 −500 233 43 −381 399 106 −626 210 −466 −720 275 394 4596 359 117 −369 −294 −249 — −16 −7108 −8150 −894 −1115 −701 −1378 * *798(H −831 −2392 1999 980 −2678 −1463 2287 −2459 551 −2391 −1516 1798−1718 62 −667 −653 −799 −2000 −2566 −1815 820 — −149 −500 233 43 −381399 106 −626 210 −466 −720 275 394 45 96 359 117 −369 −294 −249 — −16−7108 −8150 −894 −1115 −701 −1378 * * 799(M −496 −1070 −899 −350 1464−1648 −334 −716 1384 −934 2286 1246 −1730 −100 −455 −629 −434 −548 −1346−826 821 — −149 −500 233 43 −381 399 106 −626 210 −466 −720 275 394 4596 359 117 −369 −294 −249 — −16 −7108 −8150 −894 −1115 −701 −1378 * *800(I) −1200 −1080 −2894 −2252 −618 −2712 −1476 2020 −1547 1701 361−2078 −2664 −1554 1445 −1820 −1129 84 −1503 −1217 822 — −149 −500 233 43−381 399 106 −626 210 −466 −720 275 394 45 96 359 117 −369 −294 −249 —−16 −7108 −8150 −894 −1115 −701 −1378 * * 801(Q 1195 −1999 1275 287−2307 −1399 −132 −2058 888 −2010 −1104 1022 −1544 1594 −271 −396 −475−1616 −2187 −1494 823 — −149 −500 233 43 −381 399 106 −626 210 −466 −720275 394 45 96 359 117 −369 −294 −249 — −16 −7108 −8150 −894 −1115 −701−1378 * * 802(E) −464 −1834 −313 1601 −2133 −1426 −72 −1849 1475 −301−936 −76 −1522 1237 −64 −359 488 −1446 −2019 −1377 824 — −149 −500 23343 −381 399 106 −626 210 −466 −720 275 394 45 96 359 117 −369 −294 −249— −16 −7108 −8150 −894 −1115 −701 −1378 * * 803(H 1285 −1168 −1100 −753−1895 −1421 3671 −1567 −616 −1783 −1019 −796 −1815 −585 −942 −599 1325−1196 −2122 −1628 825 — −149 −500 233 43 −381 399 106 −626 210 −466 −720275 394 45 96 359 117 −369 −294 −249 — −16 −7108 −8150 −894 −1115 −701−1378 * * 804(H −457 −1111 −796 −240 1415 −1595 1499 −796 −56 −1014 −2751464 −1677 −16 1113 −558 −395 539 −1363 −816 826 — −149 −500 233 43 −381399 106 −626 210 −466 −720 275 394 45 96 359 117 −369 −294 −249 — −16−7108 −8150 −894 −1115 −701 −1378 * * 805(Q 961 −1898 742 284 −2209−1388 1553 −1951 1291 −1907 −995 −26 −1499 1771 −144 −331 −392 −1516−2082 −1407 827 — −149 −500 233 43 −381 399 106 −626 210 −466 −720 275394 45 96 359 117 −369 −294 −249 — −16 −7108 −8150 −894 −1115 −701−1378 * * 806(Y −3616 −2706 −4170 −4415 2670 −4045 −396 −2536 −3994−1940 −1985 −2748 −3931 −2852 −3447 −3296 −3495 −2687 347 4234 828 —−149 −500 233 43 −381 399 106 −626 210 −466 −720 275 394 45 96 359 117−369 −294 −249 — −16 −7108 −8150 −894 −1115 −701 −1378 * * 807(I) 1201−821 −2746 −2313 −1223 −2126 −1705 2731 −2058 −749 −304 −1944 −2428−1844 −2105 −1330 893 505 −1890 −1524 829 — −149 −500 233 43 −381 399106 −626 210 −466 −720 275 394 45 96 359 117 −369 −294 −249 — −16 −7108−8150 −894 −1115 −701 −1378 * * 808(R −841 −995 −1971 −1321 −932 −2129−856 −136 −533 −467 2304 −1291 −2194 −758 2401 −1211 −783 1416 −1446−1079 830 — −149 −500 233 43 −381 399 106 −626 210 −466 −720 275 394 4596 359 117 −369 −294 −249 — −16 −7108 −8150 −894 −1115 −701 −1378 * *809(D −1157 −2811 2313 1149 −3071 −1519 −606 −2891 −523 −2811 −1992 1715−1893 −218 −1175 1334 −1159 −2414 −2998 −2166 831 — −149 −500 233 43−381 399 106 −626 210 −466 −720 275 394 45 96 359 117 −369 −294 −249 —−16 −7108 −8150 −894 −1115 −701 −1378 * * 810(N 377 −1890 −201 941 −2201−1398 −93 −1936 1328 −1904 −1001 1972 −1518 353 −173 −356 594 −1511−2089 −1420 832 — −149 −500 233 43 −381 399 106 −626 210 −466 −720 275394 45 96 359 117 −369 −294 −249 — −16 −7108 −8150 −894 −1115 −701−1378 * * 811(G −1501 −2131 −1258 −1392 −2600 3138 2851 −3219 −1608−3233 −2576 −1477 −2541 −1589 −1850 −1578 −1737 −2674 −2756 −2168 833 —−149 −500 233 43 −381 399 106 −626 210 −466 −720 275 394 45 96 359 117−369 −294 −249 — −16 −7108 −8150 −894 −1115 −701 −1378 * * 812(Y 385−1523 −449 96 −1722 −1461 −132 −1384 959 −1486 −659 −175 −1554 1557 −186−399 1250 −1083 −1786 1631 834 — −149 −500 233 43 −381 399 106 −626 210−466 −720 275 394 45 96 359 117 −369 −294 −249 — −16 −7108 −8150 −894−1115 −701 −1378 * * 813(D −2784 −3432 4016 −1200 −4140 −2466 −2197−4505 −2621 −4365 −3956 −1551 −3014 −2039 −3232 −2593 −2938 −4046 −3710−3552 835 — −149 −500 233 43 −381 399 106 −626 210 −466 −720 275 394 4596 359 117 −369 −294 −249 — −16 −7108 −8150 −894 −1115 −701 −1378 * *814(L) −587 −625 −1931 −1364 −454 −1983 1655 818 −1068 1666 322 −1268955 −903 −1182 −1033 −529 21 −1001 −599 836 — −149 −500 233 43 −381 399106 −626 210 −466 −720 275 394 45 96 359 117 −369 −294 −249 — −16 −7108−8150 −894 −1115 −701 −1378 * * 815(P) −1667 −2676 −329 1564 −3405 −1913−1351 −3268 −1273 −3276 −2612 −852 3489 −1057 −1736 −1555 −1787 −2810−3275 −2761 837 — −149 −500 233 43 −381 399 106 −626 210 −466 −720 275394 45 96 359 117 −369 −294 −249 — −16 −7108 −8150 −894 −1115 −701−1378 * * 816(E) −1715 −3562 2447 2878 −3759 −1632 −991 −3691 −1235−3569 −2910 −235 −2166 −663 −2079 −1378 −1784 −3173 −3732 −2750 838 —−149 −500 233 43 −381 399 106 −626 210 −466 −720 275 394 45 96 359 117−369 −294 −249 — −16 −7108 −8150 −894 −1115 −701 −1378 * * 817(V −537−374 −2717 −2103 914 −2090 −949 1111 −1742 −147 443 −1675 −2132 −1398−1608 −1173 1109 1932 −845 1322 839 — −149 −500 233 43 −381 399 106 −626210 −466 −720 275 394 45 96 359 117 −369 −294 −249 — −16 −7108 −8150−894 −1115 −701 −1378 * * 818(T) −442 −1699 −325 943 −1942 −1425 −95−1640 311 −1680 −816 906 −1525 330 784 −363 1592 −1283 −1922 1369 840 —−149 −500 233 43 −381 399 106 −626 210 −466 −720 275 394 45 96 359 117−369 −294 −249 — −16 −7108 −8150 −894 −1115 −701 −1378 * * 819(D −1684−3395 2909 109 −3677 −1635 −1030 −3669 −1283 −3567 −2912 2851 −2178 −713−2110 −1377 −1776 −3137 −3688 −2726 841 — −149 −500 233 43 −381 399 106−626 210 −466 −720 275 394 45 96 359 117 −369 −294 −249 — −16 −7108−8150 −894 −1115 −701 −1378 * * 820(W −2023 −1815 −3480 −3119 26 −3133−1280 −780 −2462 −329 2687 −2604 −3188 −2264 −2350 −2462 −2001 −10675349 158 842 — −149 −500 233 43 −381 399 106 −626 210 −466 −720 275 39445 96 359 117 −369 −294 −249 — −16 −7108 −8150 −894 −1115 −701 −1378 * *821(Q −408 −1655 −342 851 −1897 −1411 −76 −1588 323 −1635 −770 −87 7851202 869 −334 619 752 −1887 −1265 843 — −149 −500 233 43 −381 399 106−626 210 −466 −720 275 394 45 96 359 117 −369 −294 −249 — −16 −7108−8150 −894 −1115 −701 −1378 * * 822(W −2077 −1892 −3023 −2742 805 −3065−450 −1653 −2397 −1546 −1211 −2106 −3118 −1977 −2345 1002 −2038 −16144785 2862 844 — −149 −500 233 43 −381 399 106 −626 210 −466 −720 275 39445 96 359 117 −369 −294 −249 — −16 −7108 −8150 −894 −1115 −701 −1378 * *823(K −479 −1638 −472 91 1024 −1483 −125 −1548 1811 −1610 −769 −180 147288 950 516 −413 −1222 −1868 −1282 845 — −149 −500 233 43 −381 399 106−626 210 −466 −720 275 394 45 96 359 117 −369 −294 −249 — −16 −7108−8150 −894 −1115 −701 −1378 * * 824(G −736 −2137 965 180 −2586 1581 −401−2350 −145 −2321 −1448 1563 712 15 −699 528 −738 −1882 −2516 −1799 846 —−149 −500 233 43 −381 399 106 −626 210 −466 −720 275 394 45 96 359 117−369 −294 −249 — −276 −7108 −2582 −894 −1115 −701 −1378 * * 825(L) −1714−1375 −3901 −3421 −618 −3530 −2616 734 −3109 2342 497 −3185 −3329 −2647−2982 −2766 −1674 1950 −2019 −1825 847 — −149 −500 233 43 −381 399 106−626 210 −466 −720 275 394 45 96 359 117 −369 −294 −249 — −19 −6850−7893 −894 −1115 −1215 −813 * * 826(K −1321 −2321 −787 −481 −2892 −1879−447 −2552 3186 −2406 −1676 717 −2074 −54 419 −1212 −1230 −2209 −2369−1979 848 — −149 −500 233 43 −381 399 106 −626 210 −466 −720 275 394 4596 359 117 −369 −294 −249 — −1043 −6850 −983 −894 −1115 −1215 −813 * *827(V 11 −281 −1388 −1014 −772 −1145 −782 672 −779 −271 145 −834 −1527−694 −967 −363 1648 1687 −1388 −977 849 — −149 −500 233 43 −381 399 106−626 210 −466 −720 275 394 45 96 359 117 −369 −294 −249 — −38 −5845−6888 −894 −1115 −2039 −402 * * 828(D −878 −1818 3239 428 −2222 −972−438 −2180 −575 −2276 −1711 95 −1458 −189 −1148 −733 −979 −1822 −2152−1652 850 — −149 −500 233 43 −381 399 106 −626 210 −466 −720 275 394 4596 359 117 −369 −294 −249 — −38 −5845 −6888 −894 −1115 −2039 −402 * *829(K −453 −1667 328 1484 −2007 −1088 173 −1659 1862 −1641 −861 236−1304 570 510 −325 −390 −1317 −1793 −1239 851 — −149 −500 233 43 −381399 106 −626 210 −466 −720 275 394 45 96 359 117 −369 −294 −249 — −38−5845 −6888 −894 −1115 −2039 −402 * * 830(K −207 −1058 −256 150 −1533−1073 83 −1043 1817 −1222 −493 −14 −1295 442 505 −228 1229 −760 −1520−1048 852 — −149 −500 233 43 −381 399 106 −626 210 −466 −720 275 394 4596 359 117 −369 −294 −249 — −38 −5845 −6888 −894 −1115 −2039 −402 * *831(G 414 −272 −462 −426 −1782 1704 −635 −1518 −577 −1737 −936 −257−1039 −416 −850 1592 98 −853 −1974 −1547 853 — −149 −500 233 43 −381 399106 −626 210 −466 −720 275 394 45 96 359 117 −369 −294 −249 — −38 −5845−6888 −894 −1115 −2039 −402 * * 832(M 1337 −339 −1188 −761 −497 −1179−525 361 −511 26 2356 −679 −1477 −431 −716 −350 −116 415 −1109 −709 854— −149 −500 233 43 −381 399 106 −626 210 −466 −720 275 394 45 96 359 117−369 −294 −249 — −38 −5845 −6888 −894 −1115 −2039 −402 * * 833(V −753−590 −2446 −1973 −226 −2358 −1433 1299 −1657 1429 779 −1837 −2356 −1469−1726 −1538 −740 2084 −1336 −966 855 — −149 −500 233 43 −381 399 106−626 210 −466 −720 275 394 45 96 359 117 −369 −294 −249 — −38 −5845−6888 −894 −1115 −2039 −402 * * 834(T) 413 −229 −707 −500 −1469 −500−543 −1022 −421 −1349 −599 −312 −1063 −330 −674 1483 1911 −534 −1729−1303 856 — −149 −500 233 43 −381 399 106 −626 210 −466 −720 275 394 4596 359 117 −369 −294 −249 — −38 −5845 −6888 −894 −1115 −2039 −402 * *835(A 2597 −310 −1033 −1004 −1499 −618 −950 −768 −944 −1290 −768 −669−1235 −852 −1081 −19 −107 −412 −1828 −1482 857 — −149 −500 233 43 −381399 106 −626 210 −466 −720 275 394 45 96 359 117 −369 −294 −249 — −38−5845 −6888 −894 −1115 −2039 −402 * * 836(T) 93 −414 −954 −868 −1353−741 −817 −616 −701 −1116 −632 −643 −1304 −696 −854 −136 2822 −336 −1700−1317 858 — −149 −500 233 43 −381 399 106 −626 210 −466 −720 275 394 4596 359 117 −369 −294 −249 — −38 −5845 −6888 −894 −1115 −2039 −402 * *837(A 2597 −310 −1033 −1004 −1499 −618 −950 −768 −944 −1290 −768 −669−1235 −852 −1081 −19 −107 −412 −1828 −1482 859 — −149 −500 233 43 −381399 106 −626 210 −466 −720 275 394 45 96 359 117 −369 −294 −249 — −38−5845 −6888 −894 −1115 −2039 −402 * * 838(A 2597 −310 −1033 −1004 −1499−618 −950 −768 −944 −1290 −768 −669 −1235 −852 −1081 −19 −107 −412 −1828−1482 860 — −149 −500 233 43 −381 399 106 −626 210 −466 −720 275 394 4596 359 117 −369 −294 −249 — −38 −5845 −6888 −894 −1115 −2039 −402 * *839(T) 93 −414 −954 −868 −1353 −741 −817 −616 −701 −1116 −632 −643 −1304−696 −854 −136 2822 −336 −1700 −1317 861 — −149 −500 233 43 −381 399 106−626 210 −466 −720 275 394 45 96 359 117 −369 −294 −249 — −38 −5845−6888 −894 −1115 −2039 −402 * * 840(A 2597 −310 −1033 −1004 −1499 −618−950 −768 −944 −1290 −768 −669 −1235 −852 −1081 −19 −107 −412 −1828−1482 862 — −149 −500 233 43 −381 399 106 −626 210 −466 −720 275 394 4596 359 117 −369 −294 −249 — −38 −5845 −6888 −894 −1115 −2039 −402 * *841(G −461 −838 −976 −1119 −2120 3148 −1219 −2101 −1326 −2273 −1700 −986−1505 −1212 −1430 −653 −781 −1558 −1923 −1928 863 — −149 −500 233 43−381 399 106 −626 210 −466 −720 275 394 45 96 359 117 −369 −294 −249 —−38 −5845 −6888 −894 −1115 −2039 −402 * * 842(D −878 −1818 3239 428−2222 −972 −438 −2180 −575 −2276 −1711 95 −1458 −189 −1148 −733 −979−1822 −2152 −1652 864 — −149 −500 233 43 −381 399 106 −626 210 −466 −720275 394 45 96 359 117 −369 −294 −249 — −38 −5845 −6888 −894 −1115 −2039−402 * * 843(N −431 −1158 164 47 −1545 −910 −407 −1680 −257 −1848 −12423201 −1391 −207 −570 −456 −599 −1296 −1696 −1106 865 — −149 −500 233 43−381 399 106 −626 210 −466 −720 275 394 45 96 359 117 −369 −294 −249 —−38 −5845 −6888 −894 −1115 −2039 −402 * * 844(E) −771 −1700 518 2837−2056 −1033 −298 −1811 −123 −1925 −1338 65 −1445 −9 −532 −658 −819 −1519−1994 −1511 866 — −149 −500 233 43 −381 399 106 −626 210 −466 −720 275394 45 96 359 117 −369 −294 −249 — −38 −5845 −6888 −894 −1115 −238−2716 * * 845( ) −30 439 11 363 −394 −739 699 −414 463 −757 501 286 −577639 165 −23 111 −312 697 −25 867— * * * * * * * * * * * * * * * * * * * * — * * * * * * * * 0

Table 7

TABLE 7 HMMER2.0 ┌2.3.2┐ NAME XFP N ACC PF09364.1 DESC XFP N-terminaldomain LENG 396 ALPH Amino RF no CS no MAP yes COM hmmbuild -f -F HMMfs.ann SEED.ann COM hmmcalibrate --seed 0 HMM fs.ann NSEQ 6 DATE Thu May3 17:57:17 2007 CKSUM 7893 GA 15.1 15.1 TC 15.1 15.1 NC 14.6 14.6 XT−8455 −4 −1000 −1000 −8455 −4 −8455 −4 NULT −4 −8455 NULE 595 −1558 85338 −294 453 −1158 197 249 902 −1085 −142 −21 −313 45 531 201 384 −1998−644 EVD −10.948357 0.672333 A C D E F G H I K HMM m->m m->i m->d i->mi->i d->m d->d b->m m->e L M N P Q R S T V W Y −193 * −3000  1(K) −1968−2951 −2155 −1320 −3390 −2747 −966 −3007 2330 −2844 −2086 −1422 2165−549 1590 −1872 −1791 −2712 −2821 1937 1 — −149 −500 233 43 −381 399 106−626 210 −466 −720 275 394 45 96 359 117 −369 −294 −249 — −11 −7944−8986 −894 −1115 −701 −1378 −1193 −9626  2(I) −1769 −1476 −4090 −3550−1526 −3579 −2618 2387 −3249 1441 −544 1396 −3532 −2933 −3155 −2723−1726 1550 −2406 −2063 2 — −149 −500 233 43 −381 399 106 −626 210 −466−720 275 394 45 96 359 117 −369 −294 −249 — −11 −7944 −8986 −894 −1115−701 −1378 −9818 −9624  3(S) −1378 −2318 1402 −1145 −3726 −2032 −1821−3503 −1805 −3583 −2748 −1309 −2587 −1497 −2321 2452 2280 −2794 −3796−3178 3 — −149 −500 233 43 −381 399 106 −626 210 −466 −720 275 394 45 96359 117 −369 −294 −249 — −11 −7944 −8986 −894 −1115 −701 −1378 −9818−9622  4(D) −2415 −4334 2560 2263 −4523 −2295 −1677 −4467 −1966 −4327−3682 −889 2279 −1352 −2856 −2064 −2494 −3929 −4515 −3478 4 — −149 −500233 43 −381 399 106 −626 210 −466 −720 275 394 45 96 359 117 −369 −294−249 — −11 −7944 −8986 −894 −1115 −701 −1378 −9818 −9620  5(E) 818 −2294−768 2387 −2689 −1890 −629 −2403 −181 −2389 −1504 −596 −2035 −193 1173−879 979 −1984 −2580 −1944 5 — −149 −500 233 43 −381 399 106 −626 210−466 −720 275 394 45 96 359 117 −369 −294 −249 — −11 −7944 −8986 −894−1115 −701 −1378 −9818 −9618  6(Y) 868 −2568 −747 2575 −2297 −2202 −1201−2582 −1098 −2680 −1956 −1001 −2523 −938 −1573 −1484 −1571 −2270 −26102844 6 — −149 −500 233 43 −381 399 106 −626 210 −466 −720 275 394 45 96359 117 −369 −294 −249 — −11 −7944 −8986 −894 −1115 −701 −1378 −9818−9617  7(L) −2772 −2280 −5308 −4845 −1620 −5006 −4218 1675 −4673 2505−404 −4676 −4560 −4047 −4494 −4304 −2713 1658 −3269 −3192 7 — −149 −500233 43 −381 399 106 −626 210 −466 −720 275 394 45 96 359 117 −369 −294−249 — −11 −7944 −8986 −894 −1115 −701 −1378 −9818 −9615  8(H) 899 −2380−623 1169 −2703 −1834 2073 −2447 1918 −2389 −1478 1301 −1952 −64 −563−794 −860 −2005 −2553 −1878 8 — −149 −500 233 43 −381 399 106 −626 210−466 −720 275 394 45 96 359 117 −369 −294 −249 — −11 −7944 −8986 −894−1115 −701 −1378 −9818 −9613  9(K) −1161 −2683 1251 −212 −2990 727 −723−2756 1972 −2690 −1794 1663 −2115 1586 −911 −1006 −1116 −2301 −2857−2139 9 — −149 −500 233 43 −381 399 106 −626 210 −466 −720 275 394 45 96359 117 −369 −294 −249 — −11 −7944 −8986 −894 −1115 −701 −1378 −9818−9611  10(M) −2709 −2269 −5162 −4623 −1349 −4724 −3702 1512 −4374 17923396 −4390 −4320 −3675 −4116 −3951 −2630 1553 −2866 −2812 10 — −149 −500233 43 −381 399 106 −626 210 −466 −720 275 394 45 96 359 117 −369 −294−249 — −11 −7944 −8986 −894 −1115 −701 −1378 −9818 −9609  11(H) −2820−4339 3411 −925 −4078 −2615 3698 −4807 −2416 −4617 −4088 −1308 −3181−1809 −3221 −2491 −2928 −4293 −4210 −3302 11 — −149 −500 233 43 −381 399106 −626 210 −466 −720 275 394 45 96 359 117 −369 −294 −249 — −11 −7944−8986 −894 −1115 −701 −1378 −9818 −9607  12(K) 1531 −2609 −1521 −881−3185 677 −855 −2809 2197 −2705 −1875 −1069 −2428 −423 1698 −1376 −1380−2418 −2783 −2320 12 — −149 −500 233 43 −381 399 106 −626 210 −466 −720275 394 45 96 359 117 −369 −294 −249 — −11 −7944 −8986 −894 −1115 −701−1378 −9818 −9605  13(Y) −4639 −3574 −5042 −5388 3053 −4919 −1116 −3531−4943 −2851 −2938 −3536 −4775 −3673 −4311 −4166 −4491 −3684 3607 3791 13— −149 −500 233 43 −381 399 106 −626 210 −466 −720 275 394 45 96 359 117−369 −294 −249 — −11 −7944 −8986 −894 −1115 −701 −1378 −9818 −9604 14(W) −3826 −3700 −3776 −3690 −1600 −3954 −2357 −4085 −2609 −3642 −3464−3450 −4249 2161 −2584 −3858 −3853 −4045 5840 −1155 14 — −149 −500 23343 −381 399 106 −626 210 −466 −720 275 394 45 96 359 117 −369 −294 −249— −11 −7944 −8986 −894 −1115 −701 −1378 −9818 −9602  15(R) −4488 −4181−4789 −4318 −5193 −4148 −3436 −5568 −2393 −5152 −4748 −4156 −4479 −32864202 −4614 −4467 −5273 −4267 −4649 15 — −149 −500 233 43 −381 399 106−626 210 −466 −720 275 394 45 96 359 117 −369 −294 −249 — −11 −7944−8986 −894 −1115 −701 −1378 −9818 −9600  16(A) 3208 −1704 −3999 −4070−3276 −2242 −3400 −1516 −3824 −2767 −2340 −2844 −2960 −3485 −3660 −1604−1654 1301 −3916 −3651 16 — −149 −500 233 43 −381 399 106 −626 210 −466−720 275 394 45 96 359 117 −369 −294 −249 — −11 −7944 −8986 −894 −1115−701 −1378 −9818 −9598  17(C) 3231 3331 −4290 −4524 −4051 −2061 −3603−3558 −4177 −4038 −3241 −2842 −2850 −3725 −3864 −1443 −1636 −2656 −4310−4227 17 — −149 −500 233 43 −381 399 106 −626 210 −466 −720 275 394 4596 359 117 −369 −294 −249 — −11 −7944 −8986 −894 −1115 −701 −1378 −9818−9596  18(N) −2093 −3624 1842 −565 −4191 −2225 −1624 −4071 −1786 −4008−3287 3436 −2749 −1290 −2544 −1859 1312 −3511 −4199 −3291 18 — −149 −500233 43 −381 399 106 −626 210 −466 −720 275 394 45 96 359 117 −369 −294−249 — −11 −7944 −8986 −894 −1115 −701 −1378 −9818 −9594  19(Y) −4605−3570 −5021 −5357 2115 −4893 −1140 −3492 −4921 −2816 −2906 −3546 −4765−3679 −4305 −4160 −4468 −3656 −389 4545 19 — −149 −500 233 43 −381 399106 −626 210 −466 −720 275 394 45 96 359 117 −369 −294 −249 — −11 −7944−8986 −894 −1115 −701 −1378 −9818 −9592  20(L) −3485 −2916 −5860 −5269−1134 −5582 −4270 1416 −5040 2720 2646 −5288 −4721 −3890 −4562 −4907−3336 −1219 −2912 −3094 20 — −149 −500 233 43 −381 399 106 −626 210 −466−720 275 394 45 96 359 117 −369 −294 −249 — −11 −7944 −8986 −894 −1115−701 −1378 −9818 −9591  21(A) 2093 −1633 −3496 −3406 −3943 1228 −3043−3705 −3256 −3935 −3021 −2418 −2652 −2942 −3281 2007 1343 −2649 −4148−3944 21 — −149 −500 233 43 −381 399 106 −626 210 −466 −720 275 394 4596 359 117 −369 −294 −249 — −11 −7944 −8986 −894 −1115 −701 −1378 −9818−9589  22(I) 1858 −1782 −4736 −4347 −2337 −4240 −3903 2415 −4179 −1341−1167 −4002 −4207 −4002 −4206 −3513 −2172 2258 −3603 −3167 22 — −149−500 233 43 −381 399 106 −626 210 −466 −720 275 394 45 96 359 117 −369−294 −249 — −11 −7944 −8986 −894 −1115 −701 −1378 −9818 −9587  23(G)−1257 −1874 −3207 −3523 −4341 3341 −3408 −4248 −3853 −4463 −3557 −2605−2866 −3402 −3760 1410 −1718 −3031 −4475 −4358 23 — −149 −500 233 43−381 399 106 −626 210 −466 −720 275 394 45 96 359 117 −369 −294 −249 —−11 −7944 −8986 −894 −1115 −701 −1378 −9818 −9585  24(M) −2521 −2386−3846 −3279 −1155 −3984 −2657 −686 −2594 1335 3429 −3250 −3784 3078−2603 −3140 −2428 −1237 −2461 −2296 24 — −149 −500 233 43 −381 399 106−626 210 −466 −720 275 394 45 96 359 117 −369 −294 −249 — −11 −7944−8986 −894 −1115 −701 −1378 −9818 −9583  25(I) −2891 −2390 −5370 −4957−1628 −5096 −4334 3554 −4751 1008 −437 −4806 −4650 −4141 −4574 −4462−2842 −63 −3311 −3180 25 — −149 −500 233 43 −381 399 106 −626 210 −466−720 275 394 45 96 359 117 −369 −294 −249 — −11 −7944 −8986 −894 −1115−701 −1378 −9818 −9581  26(Y) −4614 −3571 −5028 −5366 3123 −4901 −1136−3497 −4929 −2819 −2909 −3545 −4768 −3679 −4308 −4163 −4474 −3661 −3844150 26 — −149 −500 233 43 −381 399 106 −626 210 −466 −720 275 394 45 96359 117 −369 −294 −249 — −11 −7944 −8986 −894 −1115 −701 −1378 −9818−9579  27(L) −4119 −3542 −5389 −5357 −2027 −4767 −4358 −1609 −5118 3293−979 −5230 −4771 −4474 −4724 −5069 −4106 −2331 −3412 −3400 27 — −149−500 233 43 −381 399 106 −626 210 −466 −720 275 394 45 96 359 117 −369−294 −249 — −11 −7944 −8986 −894 −1115 −701 −1378 −9818 −9577  28(R)−1752 −2663 −1994 −1206 −3071 −2612 −927 −2620 1567 1194 −1815 −1326−2642 −523 2318 1048 −1606 −2354 −2690 −2328 28 — −149 −500 233 43 −381399 106 −626 210 −466 −720 275 394 45 96 359 117 −369 −294 −249 — −11−7944 −8986 −894 −1115 −701 −1378 −9818 −9576  29(D) −2163 −3991 28531466 −4198 −2225 −1494 −4086 −1627 −3968 −3237 1901 −2710 −1142 −2410971 −2206 −3573 −4159 −3203 29 — −149 −500 233 43 −381 399 106 −626 210−466 −720 275 394 45 96 359 117 −369 −294 −249 — −11 −7944 −8986 −894−1115 −701 −1378 −9818 −9574  30(N) −2100 −2812 −1725 −2071 −4541 1400−2845 −4689 −3101 −4717 −3995 3948 −3237 −2675 −3479 −2189 −2459 −3750−4448 −4114 30 — −149 −500 233 43 −381 399 106 −626 210 −466 −720 275394 45 96 359 117 −369 −294 −249 — −11 −7944 −8986 −894 −1115 −701 −1378−9818 −9572  31(P) −2845 −2996 −4029 −4118 −2821 −3470 −3585 −2547 −38271069 −2145 −3734 3854 −3778 −3737 −3186 −3115 −2756 −3564 −3278 31 —−149 −500 233 43 −381 399 106 −626 210 −466 −720 275 394 45 96 359 117−369 −294 −249 — −11 −7944 −8986 −894 −1115 −701 −1378 −9818 −9570 32(L) −3571 −3027 −4990 −4839 −362 −4751 −2053 −1386 −4381 2878 −762−3969 −4502 −3586 −4013 −4093 −3476 −1986 −1288 2490 32 — −149 −500 23343 −381 399 106 −626 210 −466 −720 275 394 45 96 359 117 −369 −294 −249— −11 −7944 −8986 −894 −1115 −701 −1378 −9818 −9568  33(M) −2211 −1924−4481 −3865 1786 −3872 −2670 −469 −3517 2158 2560 −3505 −3670 −2910−3263 −3004 1361 −903 −2139 −1963 33 — −149 −500 233 43 −381 399 106−626 210 −466 −720 275 394 45 96 359 117 −369 −294 −249 — −1891 −7944−464 −894 −1115 −701 −1378 −9818 −9566  34(S) 87 −526 −885 −918 −1797−699 −997 −1679 −970 −1948 −1267 −663 −1335 −874 −1147 2826 −252 −1082−2036 −1577 34 — −149 −500 233 43 −381 399 106 −626 210 −466 −720 275394 45 96 359 117 −369 −294 −249 — −34 −6087 −7129 −894 −1115 −2832 −218−9818 −9564  35(V) −734 −692 −2391 −2193 −909 −2005 −1781 1094 −1922−136 −10 −1902 −2325 −1852 −1974 −1413 −858 2960 −1857 −1405 35 — −149−500 233 43 −381 399 106 −626 210 −466 −720 275 394 45 96 359 117 −369−294 −249 — −34 −6087 −7129 −894 −1115 −2832 −218 −9818 −9562  36(T) −84−586 −1220 −1166 −1618 −901 −1090 −915 −1004 −1405 −917 −886 −1488 −990−1134 −317 3114 −605 −1941 −1587 36 — −149 −500 233 43 −381 399 106 −626210 −466 −720 275 394 45 96 359 117 −369 −294 −249 — −34 −6087 −7129−894 −1115 −133 −3510 −9818 −9560  37(R) −2583 −3338 −2968 −1938 −42262024 −1216 −3597 1648 −3282 −2594 −1884 −3156 −798 2920 −2479 −2342−3324 −3144 −3007 37 — −149 −500 233 43 −381 399 106 −626 210 −466 −720275 394 45 96 359 117 −369 −294 −249 — −11 −7944 −8986 −894 −1115 −701−1378 −9818 −9558  38(E) −1678 −2848 −628 2969 −3815 1219 −1598 −3602−1552 −3614 −2817 −1072 −2634 −1251 −2123 −1592 1327 −3012 −3808 −309138 — −149 −500 233 43 −381 399 106 −626 210 −466 −720 275 394 45 96 359117 −369 −294 −249 — −11 −7944 −8986 −894 −1115 −701 −1378 −9818 −9557 39(P) −3058 −3915 1871 −1726 −4973 −2986 −2783 −5207 −3189 −5075 −4546−2051 3849 −2577 −3857 −2918 −3276 −4561 −4629 −4315 39 — −149 −500 23343 −381 399 106 −626 210 −466 −720 275 394 45 96 359 117 −369 −294 −249— −11 −7944 −8986 −894 −1115 −701 −1378 −9818 −9555  40(L) −3389 −2846−5732 −5157 1795 −5405 −3964 1554 −4913 2673 66 −5067 −4642 −3819 −4457−4697 −3249 −1211 −2753 −2720 40 — −149 −500 233 43 −381 399 106 −626210 −466 −720 275 394 45 96 359 117 −369 −294 −249 — −11 −7944 −8986−894 −1115 −701 −1378 −9818 −9553  41(K) −1121 −2502 −1004 1296 −2888−2042 −588 −2583 2027 −2485 −1598 −681 −2119 1586 1299 −1000 1054 −2164−2595 −2010 41 — −149 −500 233 43 −381 399 106 −626 210 −466 −720 275394 45 96 359 117 −369 −294 −249 — −11 −7944 −8986 −894 −1115 −701 −1378−9818 −9551  42(P) 784 −2052 −818 1262 −2296 −1869 −546 −1970 −134 107−1190 −567 1773 −132 1208 −813 −814 −1637 −2305 −1705 42 — −149 −500 23343 −381 399 106 −626 210 −466 −720 275 394 45 96 359 117 −369 −294 −249— −11 −7944 −8986 −894 −1115 −701 −1378 −9818 −9549  43(E) −2121 −39031652 3001 −4126 −2231 −1448 −3991 1462 −3872 −3127 −825 −2693 −1089−2171 −1828 −2151 −3493 −4045 −3137 43 — −149 −500 233 43 −381 399 106−626 210 −466 −720 275 394 45 96 359 117 −369 −294 −249 — −11 −7944−8986 −894 −1115 −701 −1378 −9818 −9547  44(H) −1900 −3602 2493 −392−3825 −2165 3314 −3680 −1250 −3583 −2790 1715 −2572 1675 −1911 −1645−1910 −3197 −3754 −2893 44 — −149 −500 233 43 −381 399 106 −626 210 −466−720 275 394 45 96 359 117 −369 −294 −249 — −11 −7944 −8986 −894 −1115−701 −1378 −9818 −9545  45(I) −2547 −2059 −5152 −4751 −2029 −4889 −43882502 −4626 1616 −797 −4548 −4567 −4264 −4595 −4202 −2516 2260 −3637−3383 45 — −149 −500 233 43 −381 399 106 −626 210 −466 −720 275 394 4596 359 117 −369 −294 −249 — −11 −7944 −8986 −894 −1115 −701 −1378 −9818−9543  46(K) −4125 −4091 −4017 −3615 −5101 −3960 −2958 −5182 3972 −4825−4345 −3552 −4249 −2709 −1809 −4154 −4044 −4895 −4132 −4389 46 — −149−500 233 43 −381 399 106 −626 210 −466 −720 275 394 45 96 359 117 −369−294 −249 — −11 −7944 −8986 −894 −1115 −701 −1378 −9818 −9541  47(H) 826−2035 −963 −419 −2397 −1898 3051 −2073 −206 −2136 −1290 −675 932 −2351162 −866 1249 −1718 −2394 −1810 47 — −149 −500 233 43 −381 399 106 −626210 −466 −720 275 394 45 96 359 117 −369 −294 −249 — −11 −7944 −8986−894 −1115 −701 −1378 −9818 −9539  48(R) −2700 −3449 −3065 −1955 −4296−3222 −1177 −3628 1592 −3280 −2601 1619 −3187 −756 3400 −2568 −2401−3384 −3125 −3003 48 — −149 −500 233 43 −381 399 106 −626 210 −466 −720275 394 45 96 359 117 −369 −294 −249 — −11 −7944 −8986 −894 −1115 −701−1378 −9818 −9537  49(L) −2172 −1972 −4362 −3884 −1289 −3737 −2942 −312−3536 2565 −217 −3515 1361 −3084 −3377 −2952 −2169 1219 −2509 −2319 49 —−149 −500 233 43 −381 399 106 −626 210 −466 −720 275 394 45 96 359 117−369 −294 −249 — −11 −7944 −8986 −894 −1115 −701 −1378 −9818 −9535 50(V) −2641 −2155 −5210 −4776 −1803 −4918 −4261 1765 −4623 2179 −584−4583 −4545 −4128 −4515 −4219 −2597 2215 −3420 −3258 50 — −149 −500 23343 −381 399 106 −626 210 −466 −720 275 394 45 96 359 117 −369 −294 −249— −11 −7944 −8986 −894 −1115 −701 −1378 −9818 −9533  51(G) −4088 −3924−4774 −5139 −5615 3825 −4753 −6303 −5453 −6014 −5662 −4812 −4539 −5232−5106 −4370 −4472 −5527 −4696 −5561 51 — −149 −500 233 43 −381 399 106−626 210 −466 −720 275 394 45 96 359 117 −369 −294 −249 — −11 −7944−8986 −894 −1115 −701 −1378 −9818 −9531  52(H) −4836 −4275 −4356 −4629−3663 −4242 5422 −5932 −4492 −5436 −5298 −4579 −4696 −4620 −4352 −5005−5030 −5648 −3750 −3259 52 — −149 −500 233 43 −381 399 106 −626 210 −466−720 275 394 45 96 359 117 −369 −294 −249 — −11 −7944 −8986 −894 −1115−701 −1378 −9818 −9529  53(W) −5598 −4432 −5385 −5722 −3380 −4524 −4140−5941 −5643 −5318 −5354 −5427 −4938 −5474 −5178 −5909 −5751 −5890 6275−2993 53 — −149 −500 233 43 −381 399 106 −626 210 −466 −720 275 394 4596 359 117 −369 −294 −249 — −11 −7944 −8986 −894 −1115 −701 −1378 −9818−9527  54(G) −4088 −3924 −4774 −5139 −5615 3825 −4753 −6303 −5453 −6014−5662 −4812 −4539 −5232 −5106 −4370 −4472 −5527 −4696 −5561 54 — −149−500 233 43 −381 399 106 −626 210 −466 −720 275 394 45 96 359 117 −369−294 −249 — −11 −7944 −8986 −894 −1115 −701 −1378 −9818 −9526  55(T)−1093 −1706 −3487 −3693 −4074 −1966 −3302 −3842 −3638 −4134 −3253 −2558−2748 −3296 −3520 1110 3646 −2760 −4304 −4125 55 — −149 −500 233 43 −381399 106 −626 210 −466 −720 275 394 45 96 359 117 −369 −294 −249 — −11−7944 −8986 −894 −1115 −701 −1378 −9818 −9524  56(C) −1052 2901 −3250−2679 −1060 −2526 −1634 1315 −2341 −866 −266 −2229 −2670 −2018 −22381521 1154 1349 −1596 −1246 56 — −149 −500 233 43 −381 399 106 −626 210−466 −720 275 394 45 96 359 117 −369 −294 −249 — −11 −7944 −8986 −894−1115 −701 −1378 −9818 −9522  57(P) −1362 −1972 −3107 −3390 −4250 −2166−3327 −4213 −3641 −4411 −3553 −2613 3840 −3308 −3600 1256 −1811 −3082−4372 −4198 57 — −149 −500 233 43 −381 399 106 −626 210 −466 −720 275394 45 96 359 117 −369 −294 −249 — −11 −7944 −8986 −894 −1115 −701 −1378−9818 −9520  58(G) −4088 −3924 −4774 −5139 −5615 3825 −4753 −6303 −5453−6014 −5662 −4812 −4539 −5232 −5106 −4370 −4472 −5527 −4696 −5561 58 —−149 −500 233 43 −381 399 106 −626 210 −466 −720 275 394 45 96 359 117−369 −294 −249 — −11 −7944 −8986 −894 −1115 −701 −1378 −9818 −9518 59(Q) −2629 −2340 −4433 −3873 −1140 −4292 −3047 1389 −3342 2319 −20−3746 −4000 2559 −3238 −3469 −2536 −946 −2531 −2422 59 — −149 −500 23343 −381 399 106 −626 210 −466 −720 275 394 45 96 359 117 −369 −294 −249— −11 −7944 −8986 −894 −1115 −701 −1378 −9818 −9516  60(S) −1129 −1869−2034 −2027 −3771 −1956 −2322 −3546 −2277 −3697 −2821 2528 −2607 −2062−2583 2544 1447 −2665 −3893 −3470 60 — −149 −500 233 43 −381 399 106−626 210 −466 −720 275 394 45 96 359 117 −369 −294 −249 — −11 −7944−8986 −894 −1115 −701 −1378 −9818 −9514  61(F) −3253 −2755 −5063 −48953979 −4679 −2230 1673 −4579 −697 −843 −4029 −4483 −3735 −4216 −4008−3205 −1123 −1463 −453 61 — −149 −500 233 43 −381 399 106 −626 210 −466−720 275 394 45 96 359 117 −369 −294 −249 — −11 −7944 −8986 −894 −1115−701 −1378 −9818 −9512  62(I) −2667 −2178 −5235 −4799 −1779 −4947 −42782326 −4646 2166 −559 −4613 −4558 −4130 −4529 −4251 −2621 1716 −3410−3264 62 — −149 −500 233 43 −381 399 106 −626 210 −466 −720 275 394 4596 359 117 −369 −294 −249 — −11 −7944 −8986 −894 −1115 −701 −1378 −9818−9510  63(Y) −4030 −3324 −4830 −4953 82 −4664 −1400 −2548 −4444 776−2024 −3603 −4588 −3589 −4024 −4010 −3953 −2880 −668 4492 63 — −149 −500233 43 −381 399 106 −626 210 −466 −720 275 394 45 96 359 117 −369 −294−249 — −11 −7944 −8986 −894 −1115 −701 −1378 −9818 −9508  64(A) 2914−1624 −3741 −3790 −3997 −1911 −3253 −3736 −3609 −4009 −3103 −2541 −2685−3231 −3506 1407 1356 −2665 −4233 −4079 64 — −149 −500 233 43 −381 399106 −626 210 −466 −720 275 394 45 96 359 117 −369 −294 −249 — −11 −7944−8986 −894 −1115 −701 −1378 −9818 −9506  65(H) −4836 −4275 −4356 −4629−3663 −4242 5422 −5932 −4492 −5436 −5298 −4579 −4696 −4620 −4352 −5005−5030 −5648 −3750 −3259 65 — −149 −500 233 43 −381 399 106 −626 210 −466−720 275 394 45 96 359 117 −369 −294 −249 — −11 −7944 −8986 −894 −1115−701 −1378 −9818 −9504  66(C) 868 2955 −3843 −3261 −1152 −3113 −21291511 −2905 1928 −237 −2799 −3137 −2521 −2739 −2241 −1449 −4 −1921 −161066 — −149 −500 233 43 −381 399 106 −626 210 −466 −720 275 394 45 96 359117 −369 −294 −249 — −11 −7944 −8986 −894 −1115 −701 −1378 −9818 −9502 67(N) −3642 −3838 −3004 −3356 −4743 −3612 −3773 −5643 −4099 −5460 −50604378 −4185 −3865 −4225 −3744 −3950 −5002 −4391 −4381 67 — −149 −500 23343 −381 399 106 −626 210 −466 −720 275 394 45 96 359 117 −369 −294 −249— −11 −7944 −8986 −894 −1115 −701 −1378 −9818 −9500  68(R) −4488 −4181−4789 −4318 −5193 −4148 −3436 −5568 −2393 −5152 −4748 −4156 −4479 −32864202 −4614 −4467 −5273 −4267 −4649 68 — −149 −500 233 43 −381 399 106−626 210 −466 −720 275 394 45 96 359 117 −369 −294 −249 — −11 −7944−8986 −894 −1115 −701 −1378 −9818 −9498  69(I) 687 −1693 −4550 −4054−1797 −4053 −3239 2451 −3802 1595 −714 −3702 −3939 −3479 −3713 −3246−2027 1554 −2897 −2565 69 — −149 −500 233 43 −381 399 106 −626 210 −466−720 275 394 45 96 359 117 −369 −294 −249 — −11 −7944 −8986 −894 −1115−701 −1378 −9818 −9496  70(I) −3202 −2787 −5004 −4996 −2836 −4384 −44403937 −4838 −1815 −1871 −4704 −4600 −4683 −4704 −4353 −3280 −603 −3938−3661 70 — −149 −500 233 43 −381 399 106 −626 210 −466 −720 275 394 4596 359 117 −369 −294 −249 — −11 −7944 −8986 −894 −1115 −701 −1378 −9818−9494  71(N) 777 −2760 −1484 −853 −3260 −2383 −822 −2877 1407 −2738−1911 2481 −2455 −385 2206 −1436 −1435 −2500 −2791 −2332 71 — −149 −500233 43 −381 399 106 −626 210 −466 −720 275 394 45 96 359 117 −369 −294−249 — −11 −7944 −8986 −894 −1115 −701 −1378 −9818 −9492  72(K) −1654−2912 1393 −667 −3173 −2287 −1055 −2863 3038 286 −2070 −954 −2512 −658−811 −1519 −1598 −2533 −3029 −2434 72 — −149 −500 233 43 −381 399 106−626 210 −466 −720 275 394 45 96 359 117 −369 −294 −249 — −11 −7944−8986 −894 −1115 −701 −1378 −9818 −9490  73(Y) −3965 −3303 −4553 −44982089 −4562 2685 −3175 −3880 −2696 −2630 −3283 −4469 −3249 1301 −3756−3844 −3248 −415 3893 73 — −149 −500 233 43 −381 399 106 −626 210 −466−720 275 394 45 96 359 117 −369 −294 −249 — −11 −7944 −8986 −894 −1115−701 −1378 −9818 −9488  74(D) −2647 −4396 3720 −698 −4634 −2448 −1896−4723 −2212 −4559 −3990 −1090 −3022 1848 −3057 −2298 −2751 −4181 −4595−3647 74 — −149 −500 233 43 −381 399 106 −626 210 −466 −720 275 394 4596 359 117 −369 −294 −249 — −11 −7944 −8986 −894 −1115 −701 −1378 −9818−9486  75(Q) 786 −1836 −2085 −1707 −1785 −2491 −1572 −1296 −1287 1558−860 −1741 −2731 3104 −1481 −1664 −1471 −1312 −2370 −1975 75 — −149 −500233 43 −381 399 106 −626 210 −466 −720 275 394 45 96 359 117 −369 −294−249 — −11 −7944 −8986 −894 −1115 −701 −1378 −9818 −9484  76(N) −2189−3961 2351 −476 −4203 −2257 −1501 −4079 1323 −3955 −3231 3154 −2736−1150 −2219 −1890 −2229 −3577 −4120 −3208 76 — −149 −500 233 43 −381 399106 −626 210 −466 −720 275 394 45 96 359 117 −369 −294 −249 — −11 −7944−8986 −894 −1115 −701 −1378 −9818 −9482  77(M) −1639 −1552 −3944 −3485−1584 −3112 −2598 −102 −3126 −813 4345 −2996 −3316 −2834 −3037 −23261195 1340 −2475 −2167 77 — −149 −500 233 43 −381 399 106 −626 210 −466−720 275 394 45 96 359 117 −369 −294 −249 — −11 −7944 −8986 −894 −1115−701 −1378 −9818 −9480  78(I) −2541 −2130 −4989 −4447 1768 −4503 −34732245 −4181 1829 −210 −4162 −4181 −3554 −3947 −3708 −2469 1402 −2759−2626 78 — −149 −500 233 43 −381 399 106 −626 210 −466 −720 275 394 4596 359 117 −369 −294 −249 — −11 −7944 −8986 −894 −1115 −701 −1378 −9818−9478  79(Y) −4613 −3570 −5027 −5365 3096 −4900 −1135 −3496 −4928 −2818−2908 −3544 −4767 −3678 −4307 −4162 −4473 −3660 −383 4168 79 — −149 −500233 43 −381 399 106 −626 210 −466 −720 275 394 45 96 359 117 −369 −294−249 — −11 −7944 −8986 −894 −1115 −701 −1378 −9818 −9476  80(M) −2401−1938 −4995 −4588 −2135 −4683 −4177 2411 −4441 −955 3356 −4340 −4447−4169 −4437 −3971 −2375 2371 −3610 −3272 80 — −149 −500 233 43 −381 399106 −626 210 −466 −720 275 394 45 96 359 117 −369 −294 −249 — −11 −7944−8986 −894 −1115 −701 −1378 −9818 −9474  81(C) −924 2595 −3097 −2552−1083 823 −1551 −560 −2221 −963 2359 −2072 −2516 −1903 −2136 739 −9632007 −1573 −1229 81 — −149 −500 233 43 −381 399 106 −626 210 −466 −720275 394 45 96 359 117 −369 −294 −249 — −11 −7944 −8986 −894 −1115 −701−1378 −9818 −9472  82(G) −4088 −3924 −4774 −5139 −5615 3825 −4753 −6303−5453 −6014 −5662 −4812 −4539 −5232 −5106 −4370 −4472 −5527 −4696 −556182 — −149 −500 233 43 −381 399 106 −626 210 −466 −720 275 394 45 96 359117 −369 −294 −249 — −11 −7944 −8986 −894 −1115 −701 −1378 −9818 −9470 83(P) −4497 −4117 −4899 −5251 −5560 −4139 −4798 −6328 −5454 −5976 −5741−5026 4302 −5328 −5104 −4798 −4844 −5739 −4665 −5484 83 — −149 −500 23343 −381 399 106 −626 210 −466 −720 275 394 45 96 359 117 −369 −294 −249— −11 −7944 −8986 −894 −1115 −701 −1378 −9818 −9468  84(G) −4088 −3924−4774 −5139 −5615 3825 −4753 −6303 −5453 −6014 −5662 −4812 −4539 −5232−5106 −4370 −4472 −5527 −4696 −5561 84 — −149 −500 233 43 −381 399 106−626 210 −466 −720 275 394 45 96 359 117 −369 −294 −249 — −11 −7944−8986 −894 −1115 −701 −1378 −9818 −9466  85(H) −4836 −4275 −4356 −4629−3663 −4242 5422 −5932 −4492 −5436 −5298 −4579 −4696 −4620 −4352 −5005−5030 −5648 −3750 −3259 85 — −149 −500 233 43 −381 399 106 −626 210 −466−720 275 394 45 96 359 117 −369 −294 −249 — −11 −7944 −8986 −894 −1115−701 −1378 −9818 −9464  86(G) −4088 −3924 −4774 −5139 −5615 3825 −4753−6303 −5453 −6014 −5662 −4812 −4539 −5232 −5106 −4370 −4472 −5527 −4696−5561 86 — −149 −500 233 43 −381 399 106 −626 210 −466 −720 275 394 4596 359 117 −369 −294 −249 — −11 −7944 −8986 −894 −1115 −701 −1378 −9818−9461  87(G) 2125 −1842 −3631 −3927 −4350 3048 −3538 −4169 −4033 −4428−3528 −2733 −2876 −3575 −3846 −1489 −1707 −2984 −4482 −4443 87 — −149−500 233 43 −381 399 106 −626 210 −466 −720 275 394 45 96 359 117 −369−294 −249 — −11 −7944 −8986 −894 −1115 −701 −1378 −9818 −9459  88(P)−2640 −3260 −2127 −2297 −4320 −2987 −2661 −4510 −2216 −4379 −3792 −24113576 2864 −2373 −2683 −2863 −3935 −4069 −3806 88 — −149 −500 233 43 −381399 106 −626 210 −466 −720 275 394 45 96 359 117 −369 −294 −249 — −11−7944 −8986 −894 −1115 −701 −1378 −9818 −9457  89(A) 2982 −1594 −3754−3796 −3529 1052 −3162 −2818 −3604 −3423 −2664 −2573 −2719 −3219 −3468−1317 −1463 1086 −3887 −3678 89 — −149 −500 233 43 −381 399 106 −626 210−466 −720 275 394 45 96 359 117 −369 −294 −249 — −11 −7944 −8986 −894−1115 −701 −1378 −9818 −9455  90(M) −1348 −1165 −3573 −2973 1525 706−1766 1561 −2606 −377 3758 −2527 −2921 −2210 −2439 −2009 −1294 −310−1556 −1184 90 — −149 −500 233 43 −381 399 106 −626 210 −466 −720 275394 45 96 359 117 −369 −294 −249 — −11 −7944 −8986 −894 −1115 −701 −1378−9818 −9453  91(V) −1974 −1692 −4373 −3885 −1655 −3760 −3023 236 −35861658 −599 −3493 −3751 −3250 −3485 −2959 1156 2628 −2723 −2419 91 — −149−500 233 43 −381 399 106 −626 210 −466 −720 275 394 45 96 359 117 −369−294 −249 — −11 −7944 −8986 −894 −1115 −701 −1378 −9818 −9451  92(S)1951 −1569 −3422 −3255 −3372 1033 −2819 −2999 −3074 −3315 −2500 −2366−2636 −2776 −3104 2094 −1382 1224 −3674 −3414 92 — −149 −500 233 43 −381399 106 −626 210 −466 −720 275 394 45 96 359 117 −369 −294 −249 — −11−7944 −8986 −894 −1115 −701 −1378 −9818 −9449  93(N) 1058 −2388 −785−572 −3066 −1969 −1036 −2804 −709 −2811 −1947 2272 2144 1706 −1182 −1128−1239 −2319 −3013 −2367 93 — −149 −500 233 43 −381 399 106 −626 210 −466−720 275 394 45 96 359 117 −369 −294 −249 — −11 −7944 −8986 −894 −1115−701 −1378 −9818 −9447  94(C) −968 2761 −3158 −2743 −1848 −2096 −2020−1352 −2456 835 −1054 −2166 −2572 −2189 −2458 2381 1213 −1124 −2305−1969 94 — −149 −500 233 43 −381 399 106 −626 210 −466 −720 275 394 4596 359 117 −369 −294 −249 — −11 −7944 −8986 −894 −1115 −701 −1378 −9818−9445  95(Y) −4608 −3570 −5023 −5360 2380 −4895 −1138 −3494 −4924 −2817−2907 −3545 −4766 −3679 −4306 −4161 −4470 −3658 −386 4475 95 — −149 −500233 43 −381 399 106 −626 210 −466 −720 275 394 45 96 359 117 −369 −294−249 — −11 −7944 −8986 −894 −1115 −701 −1378 −9818 −9443  96(L) −3428−2867 −5794 −5267 −1216 −5534 −4333 1535 −5028 2951 −6 −5264 −4750 −3972−4604 −4907 −3306 −978 −2993 −3105 96 — −149 −500 233 43 −381 399 106−626 210 −466 −720 275 394 45 96 359 117 −369 −294 −249 — −11 −7944−8986 −894 −1115 −701 −1378 −9818 −9441  97(D) −2629 −4604 3026 2782−4770 −2374 −1828 −4782 −2235 −4614 −4052 −973 −2960 −1523 −3217 −2241−2730 −4225 −4757 −3689 97 — −149 −500 233 43 −381 399 106 −626 210 −466−720 275 394 45 96 359 117 −369 −294 −249 — −11 −7944 −8986 −894 −1115−701 −1378 −9818 −9439  98(G) −2862 −3768 1871 −1615 −5004 3370 −2705−5181 −3146 −5060 −4493 −1931 −3470 −2488 −3861 −2740 −3106 −4452 −4685−4318 98 — −149 −500 233 43 −381 399 106 −626 210 −466 −720 275 394 4596 359 117 −369 −294 −249 — −11 −7944 −8986 −894 −1115 −701 −1378 −9818−9437  99(T) −1078 −1695 −3486 −3659 −4077 −1954 −3276 −3853 −3599 −4130−3239 −2539 −2733 −3255 −3500 2681 2838 −2756 −4301 −4124 99 — −149 −500233 43 −381 399 106 −626 210 −466 −720 275 394 45 96 359 117 −369 −294−249 — −11 −7944 −8986 −894 −1115 −701 −1378 −9818 −9435 100(Y −3992−3300 −4836 −4941 66 −4664 −1423 −2456 −4436 992 −1925 −3615 −4579 −3584−4019 −4006 −3913 −2810 −690 4437 100 — −149 −500 233 43 −381 399 106−626 210 −466 −720 275 394 45 96 359 117 −369 −294 −249 — −11 −7944−8986 −894 −1115 −701 −1378 −9818 −9433 101(S) −1032 −1663 −3422 −3512−4087 1390 −3188 −3870 −3492 −4107 −3184 −2468 −2688 −3124 −3454 24962388 −2740 −4293 −4121 101 — −149 −500 233 43 −381 399 106 −626 210 −466−720 275 394 45 96 359 117 −369 −294 −249 — −11 −7944 −8986 −894 −1115−701 −1378 −9818 −9430 102(E −1823 −3131 −875 2933 −3614 −2362 −1174−3322 −553 −3205 −2407 −1048 1540 −771 1382 −1665 −1779 −2906 −3277−2712 102 — −149 −500 233 43 −381 399 106 −626 210 −466 −720 275 394 4596 359 117 −369 −294 −249 — −11 −7944 −8986 −894 −1115 −701 −1378 −9818−9428 103(F) 863 −914 −3349 −2737 2502 −2631 −1388 −298 −2350 698 −39−2234 −2667 −1962 −2166 −1719 −1033 1141 −1185 1869 103 — −149 −500 23343 −381 399 106 −626 210 −466 −720 275 394 45 96 359 117 −369 −294 −249— −11 −7944 −8986 −894 −1115 −701 −1378 −9818 −9426 104(Y −4352 −3468−4770 −5008 2112 −4760 −1124 −3396 −4660 −2798 −2831 1505 −4661 −3557−4156 −4005 −4236 −3515 −387 4271 104 — −149 −500 233 43 −381 399 106−626 210 −466 −720 275 394 45 96 359 117 −369 −294 −249 — −11 −7944−8986 −894 −1115 −701 −1378 −9818 −9424 105(P) 1085 −2001 −3515 −3791−4319 −2231 −3514 −4118 −3884 −4378 −3566 −2802 3892 −3541 −3758 −1662−1872 −3068 −4416 −4363 105 — −149 −500 233 43 −381 399 106 −626 210−466 −720 275 394 45 96 359 117 −369 −294 −249 — −11 −7944 −8986 −894−1115 −701 −1378 −9818 −9422 106(N −1628 −3254 1441 2076 −3527 −2085−1091 −3331 −913 −3246 −2403 2397 −2414 −688 1516 −1414 −1613 −2859−3417 −2622 106 — −149 −500 233 43 −381 399 106 −626 210 −466 −720 275394 45 96 359 117 −369 −294 −249 — −11 −7944 −8986 −894 −1115 −701 −1378−9818 −9420 107(I) −1569 2626 −3973 −3416 −1377 −3324 −2311 2751 −3082−941 −528 −2965 −3319 −2753 −2944 −2457 −1527 1473 −2109 2078 107 — −149−500 233 43 −381 399 106 −626 210 −466 −720 275 394 45 96 359 117 −369−294 −249 — −11 −7944 −8986 −894 −1115 −701 −1378 −9818 −9418 108(T 908−1834 −1592 −1168 −2951 −1885 −1379 −2651 −1086 −2760 −1898 −1245 −22951915 −1496 1739 2152 −2098 −3019 −2494 108 — −149 −500 233 43 −381 399106 −626 210 −466 −720 275 394 45 96 359 117 −369 −294 −249 — −11 −7944−8986 −894 −1115 −701 −1378 −9818 −9416 109(M −879 −2216 −787 1054 1375−1857 −485 −2215 1265 −2203 1871 −512 −1943 1655 1154 −781 −811 −1824−2400 −1773 109 — −149 −500 233 43 −381 399 106 −626 210 −466 −720 275394 45 96 359 117 −369 −294 −249 — −11 −7944 −8986 −894 −1115 −701 −1378−9818 −9414 110(D −2264 −3415 3677 −1019 −4473 −2407 −2124 −4366 −2457−4415 −3784 −1339 −3017 −1850 −3214 −2128 1551 −3724 −4492 −3732 110 —−149 −500 233 43 −381 399 106 −626 210 −466 −720 275 394 45 96 359 117−369 −294 −249 — −11 −7944 −8986 −894 −1115 −701 −1378 −9818 −9412 111(E−1628 −2756 −1092 2433 −3004 −2358 −986 −2615 1561 1281 −1850 −1034−2517 −587 −533 −1527 −1543 −2348 −2851 −2339 111 — −149 −500 233 43−381 399 106 −626 210 −466 −720 275 394 45 96 359 117 −369 −294 −249 —−11 −7944 −8986 −894 −1115 −701 −1378 −9818 −9409 112(E 800 −2932 13552151 −3219 −1985 −890 −3005 −643 −2935 −2058 1450 −2244 1611 −1220 −1179−1330 −2541 −3109 −2350 112 — −149 −500 233 43 −381 399 106 −626 210−466 −720 275 394 45 96 359 117 −369 −294 −249 — −11 −7944 −8986 −894−1115 −701 −1378 −9818 −9407 113(G −4088 −3924 −4774 −5139 −5615 3825−4753 −6303 −5453 −6014 −5662 −4812 −4539 −5232 −5106 −4370 −4472 −5527−4696 −5561 113 — −149 −500 233 43 −381 399 106 −626 210 −466 −720 275394 45 96 359 117 −369 −294 −249 — −11 −7944 −8986 −894 −1115 −701 −1378−9818 −9405 114(M −3599 −3029 −5877 −5316 −1121 −5599 −4270 −608 −50162422 4020 −5344 −4752 −3899 −4542 −4979 −3452 −1416 −2899 −3042 114 —−149 −500 233 43 −381 399 106 −626 210 −466 −720 275 394 45 96 359 117−369 −294 −249 — −11 −7944 −8986 −894 −1115 −701 −1378 −9818 −9403 115(K−1165 −2535 −1051 −455 −2930 −2079 −612 −2618 1972 −2514 −1633 1596−2153 1677 1320 873 −1075 −2202 −2617 −2045 115 — −149 −500 233 43 −381399 106 −626 210 −466 −720 275 394 45 96 359 117 −369 −294 −249 — −11−7944 −8986 −894 −1115 −701 −1378 −9818 −9401 116(K −2618 −3410 −2984−1883 −4230 −3176 −1148 −3580 2782 −3243 −2552 1766 −3140 −725 2514−2486 −2331 −3326 −3100 −2957 116 — −149 −500 233 43 −381 399 106 −626210 −466 −720 275 394 45 96 359 117 −369 −294 −249 — −11 −7944 −8986−894 −1115 −701 −1378 −9818 −9399 117(L) −3686 −3083 −5668 −5295 2704−5391 −3131 −837 −5017 2713 −141 −4846 −4727 −3862 −4511 −4763 −3544−1624 −2119 −1439 117 — −149 −500 233 43 −381 399 106 −626 210 −466 −720275 394 45 96 359 117 −369 −294 −249 — −11 −7944 −8986 −894 −1115 −701−1378 −9818 −9397 118(F) −2097 2719 −4399 −3936 3542 −3704 −2285 1698−3592 −670 −559 −3345 −3691 −3092 −3380 −2887 −2074 −315 −1780 −1028 118— −149 −500 233 43 −381 399 106 −626 210 −466 −720 275 394 45 96 359 117−369 −294 −249 — −11 −7944 −8986 −894 −1115 −701 −1378 −9818 −9394 119(K−2616 −3410 −2980 −1881 −4228 −3175 −1148 −3580 2804 −3243 −2552 1766−3139 −724 2483 −2484 −2330 −3325 −3099 −2957 119 — −149 −500 233 43−381 399 106 −626 210 −466 −720 275 394 45 96 359 117 −369 −294 −249 —−11 −7944 −8986 −894 −1115 −701 −1378 −9818 −9392 120(Q −1950 −2899−2068 −1380 −3575 −2688 −1085 −3122 5 −2965 −2212 −1472 −2788 3499 1706−1878 1393 −2788 −2974 −2647 120 — −149 −500 233 43 −381 399 106 −626210 −466 −720 275 394 45 96 359 117 −369 −294 −249 — −11 −7944 −8986−894 −1115 −701 −1378 −9818 −9390 121(F) −4720 −3927 −5139 −5454 4513−4504 −2520 −3938 −5326 −3307 −3429 −4469 −4782 −4575 −4818 −4787 −4810−4172 −1812 −736 121 — −149 −500 233 43 −381 399 106 −626 210 −466 −720275 394 45 96 359 117 −369 −294 −249 — −11 −7944 −8986 −894 −1115 −701−1378 −9818 −9388 122(S) −1944 −2458 −3696 −4011 −4410 −2644 −3753 −4675−4191 −4807 −4070 −3198 −3384 −3886 −4051 3656 −2393 −3615 −4374 −4307122 — −149 −500 233 43 −381 399 106 −626 210 −466 −720 275 394 45 96 359117 −369 −294 −249 — −11 −7944 −8986 −894 −1115 −701 −1378 −9818 −9386123(F) −4150 −3318 −4992 −5163 3777 −4801 −1232 −2695 −4739 954 −2105−3556 −4637 −3592 −4183 −4031 −4023 −3011 −484 2534 123 — −149 −500 23343 −381 399 106 −626 210 −466 −720 275 394 45 96 359 117 −369 −294 −249— −11 −7944 −8986 −894 −1115 −701 −1378 −9818 −9384 124(P) −4497 −4117−4899 −5251 −5560 −4139 −4798 −6328 −5454 −5976 −5741 −5026 4302 −5328−5104 −4798 −4844 −5739 −4665 −5484 124 — −149 −500 233 43 −381 399 106−626 210 −466 −720 275 394 45 96 359 117 −369 −294 −249 — −11 −7944−8986 −894 −1115 −701 −1378 −9818 −9382 125(G −4088 −3924 −4774 −5139−5615 3825 −4753 −6303 −5453 −6014 −5662 −4812 −4539 −5232 −5106 −4370−4472 −5527 −4696 −5561 125 — −149 −500 233 43 −381 399 106 −626 210−466 −720 275 394 45 96 359 117 −369 −294 −249 — −11 −7944 −8986 −894−1115 −701 −1378 −9818 −9379 126(G −4088 −3924 −4774 −5139 −5615 3825−4753 −6303 −5453 −6014 −5662 −4812 −4539 −5232 −5106 −4370 −4472 −5527−4696 −5561 126 — −149 −500 233 43 −381 399 106 −626 210 −466 −720 275394 45 96 359 117 −369 −294 −249 — −11 −7944 −8986 −894 −1115 −701 −1378−9818 −9377 127(I) −2878 −2414 −5081 −4778 2015 −4697 −2956 3488 −4533−580 −695 −4245 −4462 −3882 −4297 −4026 −2840 −329 −2190 −1350 127 —−149 −500 233 43 −381 399 106 −626 210 −466 −720 275 394 45 96 359 117−369 −294 −249 — −11 −7944 −8986 −894 −1115 −701 −1378 −9818 −9375128(P) −1112 −1752 −3015 −3242 −4210 2077 −3186 −4033 −3529 −4251 −3331−2415 3138 −3114 −3525 1101 −1561 −2858 −4391 −4208 128 — −149 −500 23343 −381 399 106 −626 210 −466 −720 275 394 45 96 359 117 −369 −294 −249— −11 −7944 −8986 −894 −1115 −701 −1378 −9818 −9373 129(S) −1944 −2458−3696 −4011 −4410 −2644 −3753 −4675 −4191 −4807 −4070 −3198 −3384 −3886−4051 3656 −2393 −3615 −4374 −4307 129 — −149 −500 233 43 −381 399 106−626 210 −466 −720 275 394 45 96 359 117 −369 −294 −249 — −11 −7944−8986 −894 −1115 −701 −1378 −9818 −9371 130(H −4836 −4275 −4356 −4629−3663 −4242 5422 −5932 −4492 −5436 −5298 −4579 −4696 −4620 −4352 −5005−5030 −5648 −3750 −3259 130 — −149 −500 233 43 −381 399 106 −626 210−466 −720 275 394 45 96 359 117 −369 −294 −249 — −11 −7944 −8986 −894−1115 −701 −1378 −9818 −9369 131(M 726 2516 −3320 −2699 1540 −2560 −1464−135 −2311 −587 3158 −2207 −2612 −1942 −2131 −1653 −952 1415 −1331 −989131 — −149 −500 233 43 −381 399 106 −626 210 −466 −720 275 394 45 96 359117 −369 −294 −249 — −11 −7944 −8986 −894 −1115 −701 −1378 −9818 −9366132(A 2437 −1736 −2547 −2496 −3668 −1942 −2557 −3365 −2590 −3601 −27451872 −2625 −2364 −2796 −1269 2286 −2528 −3861 −3523 132 — −149 −500 23343 −381 399 106 −626 210 −466 −720 275 394 45 96 359 117 −369 −294 −249— −11 −7944 −8986 −894 −1115 −701 −1378 −9818 −9364 133(P) 2199 −1920−3558 −3810 −4266 −2163 −3478 −4045 −3859 −4314 −3481 −2754 3455 −3500−3727 −1576 −1785 −2985 −4394 −4324 133 — −149 −500 233 43 −381 399 106−626 210 −466 −720 275 394 45 96 359 117 −369 −294 −249 — −11 −7944−8986 −894 −1115 −701 −1378 −9818 −9362 134(E −2302 −4193 1609 3106−4369 −2263 −1582 −4283 −1777 −4150 −3462 −851 −2781 1870 −2594 −1969−2359 −3762 −4338 −3341 134 — −149 −500 233 43 −381 399 106 −626 210−466 −720 275 394 45 96 359 117 −369 −294 −249 — −11 −7944 −8986 −894−1115 −701 −1378 −9818 −9360 135(T −1509 −1748 −4032 −3964 −2803 −2637−3374 −581 −3680 −2093 −1801 −3053 −3237 −3460 −3596 −1989 3160 2274−3655 −3308 135 — −149 −500 233 43 −381 399 106 −626 210 −466 −720 275394 45 96 359 117 −369 −294 −249 — −11 −7944 −8986 −894 −1115 −701 −1378−9818 −9358 136(P) −4497 −4117 −4899 −5251 −5560 −4139 −4798 −6328 −5454−5976 −5741 −5026 4302 −5328 −5104 −4798 −4844 −5739 −4665 −5484 136 —−149 −500 233 43 −381 399 106 −626 210 −466 −720 275 394 45 96 359 117−369 −294 −249 — −11 −7944 −8986 −894 −1115 −701 −1378 −9818 −9355 137(G−4088 −3924 −4774 −5139 −5615 3825 −4753 −6303 −5453 −6014 −5662 −4812−4539 −5232 −5106 −4370 −4472 −5527 −4696 −5561 137 — −149 −500 233 43−381 399 106 −626 210 −466 −720 275 394 45 96 359 117 −369 −294 −249 —−11 −7944 −8986 −894 −1115 −701 −1378 −9818 −9353 138(S) 1402 −1678−3661 −3893 −4185 −1940 −3408 −3979 −3851 −4254 −3335 −2598 −2733 −3421−3678 3267 −1525 −2799 −4407 −4277 138 — −149 −500 233 43 −381 399 106−626 210 −466 −720 275 394 45 96 359 117 −369 −294 −249 — −11 −7944−8986 −894 −1115 −701 −1378 −9818 −9351 139(I) −2917 −2413 −5393 −4971−1597 −5119 −4331 3518 −4766 1140 −403 −4828 −4654 −4126 −4574 −4483−2863 −105 −3287 −3176 139 — −149 −500 233 43 −381 399 106 −626 210 −466−720 275 394 45 96 359 117 −369 −294 −249 — −11 −7944 −8986 −894 −1115−701 −1378 −9818 −9349 140(H −2691 −3511 −1351 −1619 −2597 −2858 4977−4322 −2002 −4099 −3606 1623 −3363 −2027 −2266 −2576 −2835 −3872 −2991−2056 140 — −149 −500 233 43 −381 399 106 −626 210 −466 −720 275 394 4596 359 117 −369 −294 −249 — −11 −7944 −8986 −894 −1115 −701 −1378 −9818−9347 141(E −4205 −4417 −2343 3901 −5349 −3698 −3534 −5837 −3838 −5561−5237 −3039 −4218 −3453 −4201 −4072 −4352 −5409 −4640 −4860 141 — −149−500 233 43 −381 399 106 −626 210 −466 −720 275 394 45 96 359 117 −369−294 −249 — −11 −7944 −8986 −894 −1115 −701 −1378 −9818 −9344 142(G−4088 −3924 −4774 −5139 −5615 3825 −4753 −6303 −5453 −6014 −5662 −4812−4539 −5232 −5106 −4370 −4472 −5527 −4696 −5561 142 — −149 −500 233 43−381 399 106 −626 210 −466 −720 275 394 45 96 359 117 −369 −294 −249 —−11 −7944 −8986 −894 −1115 −701 −1378 −9818 −9342 143(G −4088 −3924−4774 −5139 −5615 3825 −4753 −6303 −5453 −6014 −5662 −4812 −4539 −5232−5106 −4370 −4472 −5527 −4696 −5561 143 — −149 −500 233 43 −381 399 106−626 210 −466 −720 275 394 45 96 359 117 −369 −294 −249 — −11 −7944−8986 −894 −1115 −701 −1378 −9818 −9340 144(E −4205 −4417 −2343 3901−5349 −3698 −3534 −5837 −3838 −5561 −5237 −3039 −4218 −3453 −4201 −4072−4352 −5409 −4640 −4860 144 — −149 −500 233 43 −381 399 106 −626 210−466 −720 275 394 45 96 359 117 −369 −294 −249 — −11 −7944 −8986 −894−1115 −701 −1378 −9818 −9338 145(L) −4119 −3542 −5389 −5357 −2027 −4767−4358 −1609 −5118 3293 −979 −5230 −4771 −4474 −4724 −5069 −4106 −2331−3412 −3400 145 — −149 −500 233 43 −381 399 106 −626 210 −466 −720 275394 45 96 359 117 −369 −294 −249 — −11 −7944 −8986 −894 −1115 −701 −1378−9818 −9335 146(G −4088 −3924 −4774 −5139 −5615 3825 −4753 −6303 −5453−6014 −5662 −4812 −4539 −5232 −5106 −4370 −4472 −5527 −4696 −5561 146 —−149 −500 233 43 −381 399 106 −626 210 −466 −720 275 394 45 96 359 117−369 −294 −249 — −11 −7944 −8986 −894 −1115 −701 −1378 −9818 −9333 147(Y−4791 −3935 −4914 −5231 −815 −4530 −2178 −4357 −5024 −3745 −3807 −4206−4772 −4328 −4584 −4677 −4837 −4435 −1477 4857 147 — −149 −500 233 43−381 399 106 −626 210 −466 −720 275 394 45 96 359 117 −369 −294 −249 —−11 −7944 −8986 −894 −1115 −701 −1378 −9818 −9331 148(C 2078 2882 −3724−3518 −2695 −2001 −2704 −2106 −3218 −2589 −1876 −2467 −2661 −2861 −31071882 −1336 1253 −3116 −2838 148 — −149 −500 233 43 −381 399 106 −626 210−466 −720 275 394 45 96 359 117 −369 −294 −249 — −11 −7944 −8986 −894−1115 −701 −1378 −9818 −9329 149(L) −4119 −3542 −5389 −5357 −2027 −4767−4358 −1609 −5118 3293 −979 −5230 −4771 −4474 −4724 −5069 −4106 −2331−3412 −3400 149 — −149 −500 233 43 −381 399 106 −626 210 −466 −720 275394 45 96 359 117 −369 −294 −249 — −11 −7944 −8986 −894 −1115 −701 −1378−9818 −9326 150(S) 1113 −1682 −3645 −3884 −4190 −1942 −3410 −3986 −3853−4261 −3343 −2598 −2736 −3423 −3680 3340 −1530 −2804 −4411 −4280 150 —−149 −500 233 43 −381 399 106 −626 210 −466 −720 275 394 45 96 359 117−369 −294 −249 — −11 −7944 −8986 −894 −1115 −701 −1378 −9818 −9324 151(H−2323 −2561 −3097 −3086 −1647 −3098 4888 −2143 −2537 −2630 −2333 −2801−3547 −2728 −2559 −2581 −2516 1445 −2255 −1333 151 — −149 −500 233 43−381 399 106 −626 210 −466 −720 275 394 45 96 359 117 −369 −294 −249 —−11 −7944 −8986 −894 −1115 −701 −1378 −9818 −9322 152(A 2928 −1667 −3720−3939 −4168 −1934 −3412 −3952 −3863 −4230 −3311 −2605 −2728 −3429 −36812146 −1516 −2782 −4394 −4269 152 — −149 −500 233 43 −381 399 106 −626210 −466 −720 275 394 45 96 359 117 −369 −294 −249 — −11 −7944 −8986−894 −1115 −701 −1378 −9818 −9320 153(Y −3656 −3073 −4655 −4705 2072−4415 −1160 −2834 −4311 −2480 −2370 −3332 −4386 −3385 −3897 −3630 1330−2897 −449 4200 153 — −149 −500 233 43 −381 399 106 −626 210 −466 −720275 394 45 96 359 117 −369 −294 −249 — −11 −7944 −8986 −894 −1115 −701−1378 −9818 −9317 154(G −4088 −3924 −4774 −5139 −5615 3825 −4753 −6303−5453 −6014 −5662 −4812 −4539 −5232 −5106 −4370 −4472 −5527 −4696 −5561154 — −149 −500 233 43 −381 399 106 −626 210 −466 −720 275 394 45 96 359117 −369 −294 −249 — −11 −7944 −8986 −894 −1115 −701 −1378 −9818 −9315155(A 3609 −2508 −4184 −4493 −4592 −2737 −3989 −4421 −4496 −4701 −4051−3440 −3474 −4171 −4253 −2294 −2487 −3536 −4484 −4643 155 — −149 −500233 43 −381 399 106 −626 210 −466 −720 275 394 45 96 359 117 −369 −294−249 — −11 −7944 −8986 −894 −1115 −701 −1378 −9818 −9313 156(I) 1599−1799 −4782 −4398 −2369 −4319 −3996 2490 −4241 −1351 −1186 −4067 −4263−4075 −4278 −3599 −2201 2395 −3673 −3229 156 — −149 −500 233 43 −381 399106 −626 210 −466 −720 275 394 45 96 359 117 −369 −294 −249 — −11 −7944−8986 −894 −1115 −701 −1378 −9818 −9311 157(F) −3470 −2920 −5747 −51773140 −5423 −3794 −632 −4917 2061 2648 −5046 −4645 −3788 −4437 −4711−3319 −1432 −2615 −2450 157 — −149 −500 233 43 −381 399 106 −626 210−466 −720 275 394 45 96 359 117 −369 −294 −249 — −11 −7944 −8986 −894−1115 −701 −1378 −9818 −9308 158(D −4232 −4465 4158 −2649 −5412 −3676−3575 −6036 −4125 −5722 −5419 −2993 −4216 −3512 −4617 −4077 −4401 −5553−4696 −4914 158 — −149 −500 233 43 −381 399 106 −626 210 −466 −720 275394 45 96 359 117 −369 −294 −249 — −11 −7944 −8986 −894 −1115 −701 −1378−9818 −9306 159(N −2152 −3226 −1659 −1246 −3822 −2724 −1126 −3401 −63−3176 −2432 3327 −2852 1866 1828 −2010 −2006 −3064 −3127 −2771 159 —−149 −500 233 43 −381 399 106 −626 210 −466 −720 275 394 45 96 359 117−369 −294 −249 — −11 −7944 −8986 −894 −1115 −701 −1378 −9818 −9304160(P) −4497 −4117 −4899 −5251 −5560 −4139 −4798 −6328 −5454 −5976 −5741−5026 4302 −5328 −5104 −4798 −4844 −5739 −4665 −5484 160 — −149 −500 23343 −381 399 106 −626 210 −466 −720 275 394 45 96 359 117 −369 −294 −249— −11 −7944 −8986 −894 −1115 −701 −1378 −9818 −9301 161(D −2185 −40232971 1468 −4227 −2230 −1509 −4119 −1656 −4000 −3274 1608 −2722 −1160−2448 972 −2231 −3604 −4191 −3227 161 — −149 −500 233 43 −381 399 106−626 210 −466 −720 275 394 45 96 359 117 −369 −294 −249 — −11 −7944−8986 −894 −1115 −701 −1378 −9818 −9299 162(L) −3047 −2911 −3749 −3527−1475 −4117 −2954 −1124 −2671 2926 −473 −3500 −4084 1801 −2645 −3601−3002 −1759 −2782 −2505 162 — −149 −500 233 43 −381 399 106 −626 210−466 −720 275 394 45 96 359 117 −369 −294 −249 — −11 −7944 −8986 −894−1115 −701 −1378 −9818 −9297 163(I) −2388 −1937 −4948 −4533 1635 −4599−3887 3268 −4365 −905 −875 −4243 −4379 −4047 −4325 −3869 −2360 1592−3319 −2869 163 — −149 −500 233 43 −381 399 106 −626 210 −466 −720 275394 45 96 359 117 −369 −294 −249 — −11 −7944 −8986 −894 −1115 −701 −1378−9818 −9295 164(V 1092 −1556 −3968 −3774 −2577 −2468 −3041 −599 −3503−2045 −1609 −2850 −3046 −3196 −3407 −1780 1216 3071 −3285 −2961 164 —−149 −500 233 43 −381 399 106 −626 210 −466 −720 275 394 45 96 359 117−369 −294 −249 — −11 −7944 −8986 −894 −1115 −701 −1378 −9818 −9292165(F) 1547 −939 −2765 −2207 1594 −2286 −1398 −514 −1927 −906 −256 −18961121 −1657 −1937 −1398 1348 1100 −1513 −1155 165 — −149 −500 233 43 −381399 106 −626 210 −466 −720 275 394 45 96 359 117 −369 −294 −249 — −11−7944 −8986 −894 −1115 −701 −1378 −9818 −9290 166(C 1272 5052 −4189−4423 −4093 1091 −3532 −3812 −4117 −4134 −3233 −2716 −2738 −3626 −3808−1304 −1508 −2711 −4345 −4265 166 — −149 −500 233 43 −381 399 106 −626210 −466 −720 275 394 45 96 359 117 −369 −294 −249 — −11 −7944 −8986−894 −1115 −701 −1378 −9818 −9288 167(V −2483 −1992 −5115 −4742 −2252−4880 −4534 1808 −4643 723 −1005 −4536 −4599 −4405 −4684 −4208 −24623131 −3865 −3512 167 — −149 −500 233 43 −381 399 106 −626 210 −466 −720275 394 45 96 359 117 −369 −294 −249 — −11 −7944 −8986 −894 −1115 −701−1378 −9818 −9285 168(V 699 −1835 −4861 −4496 −2442 −4434 −4193 1822−4360 −1374 −1231 −4183 −4356 −4220 −4421 −3732 −2257 3136 −3831 −3371168 — −149 −500 233 43 −381 399 106 −626 210 −466 −720 275 394 45 96 359117 −369 −294 −249 — −11 −7944 −8986 −894 −1115 −701 −1378 −9818 −9283169(G −4088 −3924 −4774 −5139 −5615 3825 −4753 −6303 −5453 −6014 −5662−4812 −4539 −5232 −5106 −4370 −4472 −5527 −4696 −5561 169 — −149 −500233 43 −381 399 106 −626 210 −466 −720 275 394 45 96 359 117 −369 −294−249 — −11 −7944 −8986 −894 −1115 −701 −1378 −9818 −9281 170(D −4232−4465 4158 −2649 −5412 −3676 −3575 −6036 −4125 −5722 −5419 −2993 −4216−3512 −4617 −4077 −4401 −5553 −4696 −4914 170 — −149 −500 233 43 −381399 106 −626 210 −466 −720 275 394 45 96 359 117 −369 −294 −249 — −11−7944 −8986 −894 −1115 −701 −1378 −9818 −9278 171(G −4088 −3924 −4774−5139 −5615 3825 −4753 −6303 −5453 −6014 −5662 −4812 −4539 −5232 −5106−4370 −4472 −5527 −4696 −5561 171 — −149 −500 233 43 −381 399 106 −626210 −466 −720 275 394 45 96 359 117 −369 −294 −249 — −11 −7944 −8986−894 −1115 −701 −1378 −9818 −9276 172(E −4205 −4417 −2343 3901 −5349−3698 −3534 −5837 −3838 −5561 −5237 −3039 −4218 −3453 −4201 −4072 −4352−5409 −4640 −4860 172 — −149 −500 233 43 −381 399 106 −626 210 −466 −720275 394 45 96 359 117 −369 −294 −249 — −11 −7944 −8986 −894 −1115 −701−1378 −9818 −9274 173(A 3289 −1671 −3729 −3971 −4173 −1939 −3433 −3954−3901 −4239 −3324 −2617 −2734 −3460 −3704 1119 −1523 −2786 −4402 −4279173 — −149 −500 233 43 −381 399 106 −626 210 −466 −720 275 394 45 96 359117 −369 −294 −249 — −11 −7944 −8986 −894 −1115 −701 −1378 −9818 −9271174(E −4205 −4417 −2343 3901 −5349 −3698 −3534 −5837 −3838 −5561 −5237−3039 −4218 −3453 −4201 −4072 −4352 −5409 −4640 −4860 174 — −149 −500233 43 −381 399 106 −626 210 −466 −720 275 394 45 96 359 117 −369 −294−249 — −11 −7944 −8986 −894 −1115 −701 −1378 −9818 −9269 175(T −2430−2823 −4179 −4462 −4591 −3027 −4037 −4454 −4406 −4707 −4191 −3664 −3724−4237 −4215 −2689 4010 −3747 −4431 −4588 175 — −149 −500 233 43 −381 399106 −626 210 −466 −720 275 394 45 96 359 117 −369 −294 −249 — −11 −7944−8986 −894 −1115 −701 −1378 −9818 −9267 176(G −4088 −3924 −4774 −5139−5615 3825 −4753 −6303 −5453 −6014 −5662 −4812 −4539 −5232 −5106 −4370−4472 −5527 −4696 −5561 176 — −149 −500 233 43 −381 399 106 −626 210−466 −720 275 394 45 96 359 117 −369 −294 −249 — −11 −7944 −8986 −894−1115 −701 −1378 −9818 −9264 177(P) −4497 −4117 −4899 −5251 −5560 −4139−4798 −6328 −5454 −5976 −5741 −5026 4302 −5328 −5104 −4798 −4844 −5739−4665 −5484 177 — −149 −500 233 43 −381 399 106 −626 210 −466 −720 275394 45 96 359 117 −369 −294 −249 — −11 −7944 −8986 −894 −1115 −701 −1378−9818 −9262 178(L) −2381 −2370 −4412 −4172 −1521 −3608 −3357 −845 −37412871 −437 −3695 −3832 −3365 −3575 −2971 1469 −1264 −2889 −2744 178 —−149 −500 233 43 −381 399 106 −626 210 −466 −720 275 394 45 96 359 117−369 −294 −249 — −11 −7944 −8986 −894 −1115 −701 −1378 −9818 −9260 179(A3191 −1777 −3712 −3682 −2796 −2273 −3050 −2040 −3349 −2216 2634 −2731−2945 −3125 −3255 −1630 −1688 −1822 −3467 −3179 179 — −149 −500 233 43−381 399 106 −626 210 −466 −720 275 394 45 96 359 117 −369 −294 −249 —−11 −7944 −8986 −894 −1115 −701 −1378 −9818 −9257 180(T 1105 −1691 −3751−3950 −4036 −1980 −3391 −3579 −3788 −4004 −3179 −2639 −2764 −3418 −3611−1351 3649 −2631 −4299 −4165 180 — −149 −500 233 43 −381 399 106 −626210 −466 −720 275 394 45 96 359 117 −369 −294 −249 — −11 −7944 −8986−894 −1115 −701 −1378 −9818 −9255 181(S) 1115 −1654 −3622 −3791 −41921188 −3347 −3991 −3762 −4236 −3295 −2550 −2702 −3327 −3634 3032 −1489−2786 −4402 −4277 181 — −149 −500 233 43 −381 399 106 −626 210 −466 −720275 394 45 96 359 117 −369 −294 −249 — −11 −7944 −8986 −894 −1115 −701−1378 −9818 −9253 182( −5598 −4432 −5385 −5722 −3380 −4524 −4140 −5941−5643 −5318 −5354 −5427 −4938 −5474 −5178 −5909 −5751 −5890 6275 −2993182 — −149 −500 233 43 −381 399 106 −626 210 −466 −720 275 394 45 96 359117 −369 −294 −249 — −11 −7944 −8986 −894 −1115 −701 −1378 −9818 −9250183(H −2817 −3584 −1743 −1758 −2728 −3054 4625 −4009 −1063 −3728 −3189−1926 −3378 2752 −1170 −2680 −2782 −3708 −2912 −2121 183 — −149 −500 23343 −381 399 106 −626 210 −466 −720 275 394 45 96 359 117 −369 −294 −249— −11 −7944 −8986 −894 −1115 −701 −1378 −9818 −9248 184(S) 2113 −1671−3691 −3909 −4175 −1935 −3404 −3963 −3845 −4238 −3318 −2599 −2728 −3415−3673 2974 −1518 −2788 −4398 −4270 184 — −149 −500 233 43 −381 399 106−626 210 −466 −720 275 394 45 96 359 117 −369 −294 −249 — −11 −7944−8986 −894 −1115 −701 −1378 −9818 −9246 185(N −1667 −2295 −1303 −1206−1708 −2454 2688 1228 −1127 −2276 −1659 3307 −2730 −1191 −1399 −1726−1677 −1853 −2144 −1341 185 — −149 −500 233 43 −381 399 106 −626 210−466 −720 275 394 45 96 359 117 −369 −294 −249 — −11 −7944 −8986 −894−1115 −701 −1378 −9818 −9243 186(K −4125 −4091 −4017 −3615 −5101 −3960−2958 −5182 3972 −4825 −4345 −3552 −4249 −2709 −1809 −4154 −4044 −4895−4132 −4389 186 — −149 −500 233 43 −381 399 106 −626 210 −466 −720 275394 45 96 359 117 −369 −294 −249 — −11 −7944 −8986 −894 −1115 −701 −1378−9818 −9241 187(F) −3793 −3163 −5295 −5191 4063 −5003 −2160 −1329 −48451075 −704 −4205 −4663 −3781 −4356 −4376 −3689 −1985 −1339 −323 187 —−149 −500 233 43 −381 399 106 −626 210 −466 −720 275 394 45 96 359 117−369 −294 −249 — −11 −7944 −8986 −894 −1115 −701 −1378 −9818 −9238188(I) −2691 −2201 −5254 −4813 −1747 −4966 −4275 2399 −4658 2193 −527−4632 −4563 −4118 −4528 −4270 −2643 1553 −3385 −3255 188 — −149 −500 23343 −381 399 106 −626 210 −466 −720 275 394 45 96 359 117 −369 −294 −249— −11 −7944 −8986 −894 −1115 −701 −1378 −9818 −9236 189(N −2608 −43121902 −698 −4665 −2423 −1924 −4776 −2319 −4628 −4060 3855 −3013 −1633−3242 −2275 −2738 −4189 −4662 −3683 189 — −149 −500 233 43 −381 399 106−626 210 −466 −720 275 394 45 96 359 117 −369 −294 −249 — −11 −7944−8986 −894 −1115 −701 −1378 −9818 −9234 190(P) −4497 −4117 −4899 −5251−5560 −4139 −4798 −6328 −5454 −5976 −5741 −5026 4302 −5328 −5104 −4798−4844 −5739 −4665 −5484 190 — −149 −500 233 43 −381 399 106 −626 210−466 −720 275 394 45 96 359 117 −369 −294 −249 — −11 −7944 −8986 −894−1115 −701 −1378 −9818 −9231 191(A 1597 −1385 −1621 −1030 −1453 −2189−892 994 1158 −1265 −571 −1153 −2261 −699 1188 −1186 −908 900 −1781−1350 191 — −149 −500 233 43 −381 399 106 −626 210 −466 −720 275 394 4596 359 117 −369 −294 −249 — −11 −7944 −8986 −894 −1115 −701 −1378 −9818−9229 192(R −1138 −2535 −738 1346 −2893 −1985 −675 −2612 −163 −2551−1669 1495 −2128 −235 2008 −1012 1851 −2189 −2703 −2067 192 — −149 −500233 43 −381 399 106 −626 210 −466 −720 275 394 45 96 359 117 −369 −294−249 — −11 −7944 −8986 −894 −1115 −701 −1378 −9818 −9226 193(D −2243−3522 3665 −856 −4525 −2330 −2015 −4560 −2391 −4501 −3857 −1194 −2947−1733 −3224 1260 −2461 −3845 −4571 −3690 193 — −149 −500 233 43 −381 399106 −626 210 −466 −720 275 394 45 96 359 117 −369 −294 −249 — −11 −7944−8986 −894 −1115 −701 −1378 −9818 −9224 194(G −4088 −3924 −4774 −5139−5615 3825 −4753 −6303 −5453 −6014 −5662 −4812 −4539 −5232 −5106 −4370−4472 −5527 −4696 −5561 194 — −149 −500 233 43 −381 399 106 −626 210−466 −720 275 394 45 96 359 117 −369 −294 −249 — −11 −7944 −8986 −894−1115 −701 −1378 −9818 −9222 195(A 3150 −1781 −3954 −3897 −2697 −2590−3290 1498 −3639 −1978 −1734 −3003 −3197 −3386 −3549 −1945 −1810 −689−3544 −3207 195 — −149 −500 233 43 −381 399 106 −626 210 −466 −720 275394 45 96 359 117 −369 −294 −249 — −11 −7944 −8986 −894 −1115 −701 −1378−9818 −9219 196(V −2448 −1959 −5109 −4794 −2563 −4877 −4851 1886 −4730−1341 −1284 −4579 −4666 −4653 −4865 −4248 −2447 3388 −4252 −3753 196 —−149 −500 233 43 −381 399 106 −626 210 −466 −720 275 394 45 96 359 117−369 −294 −249 — −11 −7944 −8986 −894 −1115 −701 −1378 −9818 −9217197(L) −3405 −2846 −5779 −5255 −1228 −5518 −4333 1719 −5019 2902 −18−5245 −4745 −3976 −4603 −4888 −3285 −936 −3002 −3110 197 — −149 −500 23343 −381 399 106 −626 210 −466 −720 275 394 45 96 359 117 −369 −294 −249— −11 −7944 −8986 −894 −1115 −701 −1378 −9818 −9214 198(P) −4497 −4117−4899 −5251 −5560 −4139 −4798 −6328 −5454 −5976 −5741 −5026 4302 −5328−5104 −4798 −4844 −5739 −4665 −5484 198 — −149 −500 233 43 −381 399 106−626 210 −466 −720 275 394 45 96 359 117 −369 −294 −249 — −11 −7944−8986 −894 −1115 −701 −1378 −9818 −9212 199(I) −2459 −1963 −5126 −4808−2568 −4914 −4889 3247 −4751 −1338 −1283 −4603 −4685 −4676 −4891 −4286−2455 2426 −4274 −3777 199 — −149 −500 233 43 −381 399 106 −626 210 −466−720 275 394 45 96 359 117 −369 −294 −249 — −11 −7944 −8986 −894 −1115−701 −1378 −9818 −9209 200(L) −4119 −3542 −5389 −5357 −2027 −4767 −4358−1609 −5118 3293 −979 −5230 −4771 −4474 −4724 −5069 −4106 −2331 −3412−3400 200 — −149 −500 233 43 −381 399 106 −626 210 −466 −720 275 394 4596 359 117 −369 −294 −249 — −11 −7944 −8986 −894 −1115 −701 −1378 −9818−9207 201(H −2395 −4306 1759 1612 −4428 −2292 4419 −4404 −1894 −4265−3611 −881 −2831 −1320 −2741 −2046 −2464 −3880 −4428 −3405 201 — −149−500 233 43 −381 399 106 −626 210 −466 −720 275 394 45 96 359 117 −369−294 −249 — −11 −7944 −8986 −894 −1115 −701 −1378 −9818 −9205 202(L)−4119 −3542 −5389 −5357 −2027 −4767 −4358 −1609 −5118 3293 −979 −5230−4771 −4474 −4724 −5069 −4106 −2331 −3412 −3400 202 — −149 −500 233 43−381 399 106 −626 210 −466 −720 275 394 45 96 359 117 −369 −294 −249 —−11 −7944 −8986 −894 −1115 −701 −1378 −9818 −9202 203(N −3642 −3838−3004 −3356 −4743 −3612 −3773 −5643 −4099 −5460 −5060 4378 −4185 −3865−4225 −3744 −3950 −5002 −4391 −4381 203 — −149 −500 233 43 −381 399 106−626 210 −466 −720 275 394 45 96 359 117 −369 −294 −249 — −11 −7944−8986 −894 −1115 −701 −1378 −9818 −9200 204(G −4088 −3924 −4774 −5139−5615 3825 −4753 −6303 −5453 −6014 −5662 −4812 −4539 −5232 −5106 −4370−4472 −5527 −4696 −5561 204 — −149 −500 233 43 −381 399 106 −626 210−466 −720 275 394 45 96 359 117 −369 −294 −249 — −11 −7944 −8986 −894−1115 −701 −1378 −9818 −9197 205(Y −4606 −3570 −5022 −5359 2254 −4894−1139 −3493 −4923 −2816 −2906 −3546 −4765 −3679 −4305 −4161 −4469 −3657−387 4510 205 — −149 −500 233 43 −381 399 106 −626 210 −466 −720 275 39445 96 359 117 −369 −294 −249 — −11 −7944 −8986 −894 −1115 −701 −1378−9818 −9195 206(K −4125 −4091 −4017 −3615 −5101 −3960 −2958 −5182 3972−4825 −4345 −3552 −4249 −2709 −1809 −4154 −4044 −4895 −4132 −4389 206 —−149 −500 233 43 −381 399 106 −626 210 −466 −720 275 394 45 96 359 117−369 −294 −249 — −11 −7944 −8986 −894 −1115 −701 −1378 −9818 −9192207(I) −3202 −2787 −5004 −4996 −2836 −4384 −4440 3937 −4838 −1815 −1871−4704 −4600 −4683 −4704 −4353 −3280 −603 −3938 −3661 207 — −149 −500 23343 −381 399 106 −626 210 −466 −720 275 394 45 96 359 117 −369 −294 −249— −11 −7944 −8986 −894 −1115 −701 −1378 −9818 −9190 208(S) 1943 −1773−2482 −2503 −3907 −1935 −2647 −3686 −2717 −3870 −2975 1555 −2640 −2445−2934 2632 −1475 −2699 −4064 −3728 208 — −149 −500 233 43 −381 399 106−626 210 −466 −720 275 394 45 96 359 117 −369 −294 −249 — −11 −7944−8986 −894 −1115 −701 −1378 −9818 −9187 209(N −2546 −4182 −358 1608−4553 −2427 −1858 −4587 −2065 −4451 −3846 3842 −2989 −1553 −2799 −2233−2653 −4040 −4492 −3586 209 — −149 −500 233 43 −381 399 106 −626 210−466 −720 275 394 45 96 359 117 −369 −294 −249 — −11 −7944 −8986 −894−1115 −701 −1378 −9818 −9185 210(P) −3075 −3411 −3652 −3377 −4713 −3421−2871 −4754 −1885 −4551 −3970 −3201 3874 −2637 1884 −3201 −3246 −4233−4063 −4155 210 — −149 −500 233 43 −381 399 106 −626 210 −466 −720 275394 45 96 359 117 −369 −294 −249 — −11 −7944 −8986 −894 −1115 −701 −1378−9818 −9182 211(T −1093 −1706 −3487 −3693 −4074 −1966 −3302 −3842 −3638−4134 −3253 −2558 −2748 −3296 −3520 1110 3646 −2760 −4304 −4125 211 —−149 −500 233 43 −381 399 106 −626 210 −466 −720 275 394 45 96 359 117−369 −294 −249 — −11 −7944 −8986 −894 −1115 −701 −1378 −9818 −9180212(I) −2500 −2007 −5132 −4756 −2220 −4898 −4538 2959 −4657 869 −973−4554 −4605 −4399 −4689 −4227 −2477 2250 −3844 −3510 212 — −149 −500 23343 −381 399 106 −626 210 −466 −720 275 394 45 96 359 117 −369 −294 −249— −11 −7944 −8986 −894 −1115 −701 −1378 −9818 −9177 213(Y −3774 −3094−5016 −5007 2147 −4760 −1471 −1948 −4610 2513 −1319 −3670 −4532 −3545−4108 −3980 −3652 −2427 −717 2621 213 — −149 −500 233 43 −381 399 106−626 210 −466 −720 275 394 45 96 359 117 −369 −294 −249 — −11 −7944−8986 −894 −1115 −701 −1378 −9818 −9175 214(A 2561 −1647 −3667 −3813−4167 1400 −3339 −3961 −3748 −4207 −3269 −2554 −2698 −3319 −3621 1972−1482 −2770 −4380 −4254 214 — −149 −500 233 43 −381 399 106 −626 210−466 −720 275 394 45 96 359 117 −369 −294 −249 — −11 −7944 −8986 −894−1115 −701 −1378 −9818 −9172 215(R −2761 3372 −4411 −3701 −4318 −3291−2762 −4186 −1690 −4160 −3592 −3256 −3742 −2538 3812 −2949 −2961 −3734−3870 −3866 215 — −149 −500 233 43 −381 399 106 −626 210 −466 −720 275394 45 96 359 117 −369 −294 −249 — −11 −7944 −8986 −894 −1115 −701 −1378−9818 −9170 216(I) −1976 −1690 −4334 −3831 −1599 −3763 −2958 3100 −3513−670 2664 −3459 −3733 −3184 −3413 −2951 1215 192 −2661 −2363 216 — −149−500 233 43 −381 399 106 −626 210 −466 −720 275 394 45 96 359 117 −369−294 −249 — −11 −7944 −8986 −894 −1115 −701 −1378 −9818 −9167 217(S)−1740 −2857 1787 −890 −4083 −2148 −1822 −3944 −1950 −3947 −3166 −11642282 −1503 −2599 2462 −1955 −3236 −4123 −3368 217 — −149 −500 233 43−381 399 106 −626 210 −466 −720 275 394 45 96 359 117 −369 −294 −249 —−11 −7944 −8986 −894 −1115 −701 −1378 −9818 −9165 218(D −1796 −3465 29561278 −3721 −2140 2354 −3541 1157 −3446 −2631 −742 −2513 −824 −1706 −1558−1793 −3064 −3617 −2792 218 — −149 −500 233 43 −381 399 106 −626 210−466 −720 275 394 45 96 359 117 −369 −294 −249 — −11 −7944 −8986 −894−1115 −701 −1378 −9818 −9162 219(D −1468 −2962 2158 2010 −3256 −2035−1014 −3010 −825 −2993 −2150 −673 −2334 −612 −1413 1100 −1455 908 −3204−2451 219 — −149 −500 233 43 −381 399 106 −626 210 −466 −720 275 394 4596 359 117 −369 −294 −249 — −11 −7944 −8986 −894 −1115 −701 −1378 −9818−9160 220(E −2636 −4572 1783 3438 −4760 −2391 −1842 −4773 −2236 −4607−4040 −996 −2973 −1538 −3199 −2254 −2736 −4219 −4732 −3692 220 — −149−500 233 43 −381 399 106 −626 210 −466 −720 275 394 45 96 359 117 −369−294 −249 — −11 −7944 −8986 −894 −1115 −701 −1378 −9818 −9157 221(L)−3421 −2860 −5790 −5264 −1219 −5529 −4333 1589 −5025 2937 −9 −5258 −4748−3973 −4603 −4902 −3300 −965 −2995 −3106 221 — −149 −500 233 43 −381 399106 −626 210 −466 −720 275 394 45 96 359 117 −369 −294 −249 — −11 −7944−8986 −894 −1115 −701 −1378 −9818 −9155 222(H −1434 −2670 −1420 1033−3099 −2316 2338 −2728 1395 511 −1776 −966 −2367 −301 2245 −1323 −1317−2360 −2690 −2208 222 — −149 −500 233 43 −381 399 106 −626 210 −466 −720275 394 45 96 359 117 −369 −294 −249 — −11 −7944 −8986 −894 −1115 −701−1378 −9818 −9152 223(K 1469 −2443 1279 −267 −2862 −1879 −707 −2612 1960−2574 −1677 −575 −2071 −271 −856 1040 −1018 −2154 −2755 −2069 223 — −149−500 233 43 −381 399 106 −626 210 −466 −720 275 394 45 96 359 117 −369−294 −249 — −11 −7944 −8986 −894 −1115 −701 −1378 −9818 −9150 224(F)−3694 −3088 −5579 −5263 3299 −5296 −2867 −919 −4969 2350 −235 −4680−4707 −3837 −4468 −4661 −3559 −1683 −1918 −1128 224 — −149 −500 233 43−381 399 106 −626 210 −466 −720 275 394 45 96 359 117 −369 −294 −249 —−11 −7944 −8986 −894 −1115 −701 −1378 −9818 −9147 225(F) −4720 −3927−5139 −5454 4513 −4504 −2520 −3938 −5326 −3307 −3429 −4469 −4782 −4575−4818 −4787 −4810 −4172 −1812 −736 225 — −149 −500 233 43 −381 399 106−626 210 −466 −720 275 394 45 96 359 117 −369 −294 −249 — −11 −7944−8986 −894 −1115 −701 −1378 −9818 −9145 226(E 688 −2344 −716 2314 −2761−1878 −641 −2492 −210 −2459 −1564 −580 −2036 −201 1256 1020 −948 −2051−2637 −1982 226 — −149 −500 233 43 −381 399 106 −626 210 −466 −720 275394 45 96 359 117 −369 −294 −249 — −11 −7944 −8986 −894 −1115 −701 −1378−9818 −9142 227(G −4088 −3924 −4774 −5139 −5615 3825 −4753 −6303 −5453−6014 −5662 −4812 −4539 −5232 −5106 −4370 −4472 −5527 −4696 −5561 227 —−149 −500 233 43 −381 399 106 −626 210 −466 −720 275 394 45 96 359 117−369 −294 −249 — −11 −7944 −8986 −894 −1115 −701 −1378 −9818 −9140 228(Y−1597 −1396 −3573 −3051 2007 −3040 −1283 −840 −2686 801 2421 1263 −3058−2245 −2516 −2133 −1532 −823 −882 2863 228 — −149 −500 233 43 −381 399106 −626 210 −466 −720 275 394 45 96 359 117 −369 −294 −249 — −11 −7944−8986 −894 −1115 −701 −1378 −9818 −9137 229(G −4088 −3924 −4774 −5139−5615 3825 −4753 −6303 −5453 −6014 −5662 −4812 −4539 −5232 −5106 −4370−4472 −5527 −4696 −5561 229 — −149 −500 233 43 −381 399 106 −626 210−466 −720 275 394 45 96 359 117 −369 −294 −249 — −11 −7944 −8986 −894−1115 −701 −1378 −9818 −9134 230(Y −4620 −3593 −5015 −5337 280 −4863−1187 −3570 −4864 −2899 −2980 −3577 −4762 −3702 −4279 −4188 −4490 −37193436 4551 230 — −149 −500 233 43 −381 399 106 −626 210 −466 −720 275 39445 96 359 117 −369 −294 −249 — −11 −7944 −8986 −894 −1115 −701 −1378−9818 −9132 231(H −862 −2311 −632 1878 −2629 −1803 2148 −2371 1173 −2322−1409 −442 −1911 −24 −537 854 933 −1933 −2493 −1820 231 — −149 −500 23343 −381 399 106 −626 210 −466 −720 275 394 45 96 359 117 −369 −294 −249— −11 −7944 −8986 −894 −1115 −701 −1378 −9818 −9129 232(P) −1820 −2216−3792 −3938 −3452 −2669 −3505 −2107 −3787 −3057 −2729 −3136 3804 −3614−3691 −2143 −2196 1506 −3938 −3681 232 — −149 −500 233 43 −381 399 106−626 210 −466 −720 275 394 45 96 359 117 −369 −294 −249 — −11 −7944−8986 −894 −1115 −701 −1378 −9818 −9127 233(Y 996 −1294 −2366 −1763 −954−2474 −1131 −841 −1179 533 −479 −1680 −2552 −1243 1281 −1538 −1120 −749−1438 3229 233 — −149 −500 233 43 −381 399 106 −626 210 −466 −720 275394 45 96 359 117 −369 −294 −249 — −11 −7944 −8986 −894 −1115 −701 −1378−9818 −9124 234(F) −1969 −1770 −3543 966 3139 −3305 −1223 1499 −2815−1359 −912 −2576 −3319 −2375 −2708 −2407 −1903 −1180 −760 2316 234 —−149 −500 233 43 −381 399 106 −626 210 −466 −720 275 394 45 96 359 117−369 −294 −249 — −11 −7944 −8986 −894 −1115 −701 −1378 −9818 −9122 235(V−2342 −1893 −4914 −4505 1622 −4568 −3913 1826 −4342 −1030 −963 −4213−4369 −4072 −4326 −3838 −2317 3076 −3397 −2930 235 — −149 −500 233 43−381 399 106 −626 210 −466 −720 275 394 45 96 359 117 −369 −294 −249 —−11 −7944 −8986 −894 −1115 −701 −1378 −9818 −9119 236(E 722 −2323 −6532387 −2684 −1948 −848 −2315 −559 −2434 −1603 1662 −2171 −449 −1065 −1048−1111 813 −2716 −2073 236 — −149 −500 233 43 −381 399 106 −626 210 −466−720 275 394 45 96 359 117 −369 −294 −249 — −11 −7944 −8986 −894 −1115−701 −1378 −9818 −9116 237(G 917 −3198 1792 −603 −3972 2355 −1545 −3811−1605 −3767 −2983 1737 −2642 −1194 −2291 −1663 −1944 −3223 −3965 −3136237 — −149 −500 233 43 −381 399 106 −626 210 −466 −720 275 394 45 96 359117 −369 −294 −249 — −1266 −7944 −790 −894 −1115 −701 −1378 −9818 −9114238(D −1223 −2437 2763 82 −3208 2150 −912 −3128 −1082 −3109 −2410 −254−1932 −608 −1769 −1060 −1365 −2572 −3146 −2456 238 — −149 −500 233 43−376 399 106 −626 210 −466 −720 275 394 45 96 359 117 −369 −294 −249 —−649 −1491 −7744 −157 −3277 −2587 −263 −9818 −9111 239(D −2102 −29023872 −571 −3494 −1911 −1556 −3716 −1893 −3662 −3195 −920 −2449 −1361−2516 −1915 −2242 −3285 −3201 −2890 240 — −149 −500 233 43 −381 399 106−626 210 −466 −720 275 394 45 96 359 117 −369 −294 −249 — −23 −6702−7744 −894 −1115 −2587 −263 −9818 −9109 240(N −694 −999 −1141 −940 −1064−1767 −919 2282 −849 −787 −349 2352 −2038 −817 −1093 −1000 −743 143−1624 −1073 241 — −149 −500 233 43 −381 399 106 −626 210 −466 −720 275394 45 96 359 117 −369 −294 −249 — −23 −6702 −7744 −894 −1115 −562 −1632−9818 −9106 241(H −1431 −2871 −230 2243 −3163 −1925 3560 −3017 −719−2971 −2155 −593 −2261 −564 −1242 1041 −1433 −2572 −3114 −2362 242 —−149 −500 233 43 −381 399 106 −626 210 −466 −720 275 394 45 96 359 117−369 −294 −249 — −13 −7670 −8713 −894 −1115 −1555 −600 −9818 −9103 242(D−2381 −4329 3618 1594 −4505 −2138 −1588 −4512 −1982 −4352 −3784 −740−2721 −1283 −2949 −1999 −2481 −3960 −4490 −3437 243 — −149 −500 233 43−381 399 106 −626 210 −466 −720 275 394 45 96 359 117 −369 −294 −249 —−13 −7670 −8713 −894 −1115 −345 −2232 −9818 −9101 243(P) −1293 −1824−1648 −1248 −1123 −2332 2376 −1662 −1068 −1836 −1165 −1350 2605 −1031−1373 −1420 1364 −1468 −1606 2015 244 — −149 −500 233 43 −381 399 106−626 210 −466 −720 275 394 45 96 359 117 −369 −294 −249 — −11 −7944−8987 −894 −1115 −701 −1378 −9818 −9098 244(M 683 −1426 −1284 1643 −1482−2033 −782 −1054 −631 424 2181 −936 1207 −541 −1010 −1010 −810 −892−1806 −1337 245 — −149 −500 233 43 −381 399 106 −626 210 −466 −720 275394 45 96 359 117 −369 −294 −249 — −11 −7944 −8987 −894 −1115 −701 −1378−9818 −9095 245(S) 861 −1834 1340 −516 −2191 −1877 −758 −1838 −462 203−1169 −752 −2056 −387 −921 1571 1006 −1523 −2319 −1756 246 — −149 −500233 43 −381 399 106 −626 210 −466 −720 275 394 45 96 359 117 −369 −294−249 — −11 −7944 −8987 −894 −1115 −701 −1378 −9818 −9093 246(M −1263−1161 −3038 −2448 −745 −2739 −1453 1314 −2054 −532 3663 −2170 −2762 1690−2026 −1815 −1199 −464 −1382 1937 247 — −149 −500 233 43 −381 399 106−626 210 −466 −720 275 394 45 96 359 117 −369 −294 −249 — −11 −7944−8987 −894 −1115 −701 −1378 −9818 −9090 247(H −2671 −3516 −1308 −1575−2624 −2837 4896 −4310 −1982 −4092 −3590 1952 −3342 −1994 −2257 −2551−2812 −3859 −3012 −2078 248 — −149 −500 233 43 −381 399 106 −626 210−466 −720 275 394 45 96 359 117 −369 −294 −249 — −11 −7944 −8987 −894−1115 −701 −1378 −9818 −9087 248(R −2804 −3490 −3516 −2098 −4381 −3320−1175 −3662 2379 −3289 −2620 −1979 −3242 2620 2657 −2671 −2465 −3437−3117 −3033 249 — −149 −500 233 43 −381 399 106 −626 210 −466 −720 275394 45 96 359 117 −369 −294 −249 — −11 −7944 −8987 −894 −1115 −701 −1378−9818 −9085 249(R 732 −1128 −2794 −2187 −1101 −2570 −1459 −356 −16831417 −262 −1988 −2651 −1613 1995 −1657 −1104 1378 −1647 −1297 250 — −149−500 233 43 −381 399 106 −626 210 −466 −720 275 394 45 96 359 117 −369−294 −249 — −11 −7944 −8987 −894 −1115 −701 −1378 −9818 −9082 250(M 923−1665 −3899 −3427 1737 −3128 −2177 −660 −3081 −421 4324 −2915 −3268−2649 −2926 −2316 −1774 −849 −1851 −1321 251 — −149 −500 233 43 −381 399106 −626 210 −466 −720 275 394 45 96 359 117 −369 −294 −249 — −11 −7944−8987 −894 −1115 −701 −1378 −9818 −9079 251(A 3609 −2508 −4184 −4493−4592 −2737 −3989 −4421 −4496 −4701 −4051 −3440 −3474 −4171 −4253 −2294−2487 −3536 −4484 −4643 252 — −149 −500 233 43 −381 399 106 −626 210−466 −720 275 394 45 96 359 117 −369 −294 −249 — −11 −7944 −8987 −894−1115 −701 −1378 −9818 −9077 252(E 1863 −2261 −1000 2576 −3283 −2007−1447 −2956 −1252 −3072 −2244 −1127 −2442 −1087 −1727 −1275 1155 −2422−3329 −2724 253 — −149 −500 233 43 −381 399 106 −626 210 −466 −720 275394 45 96 359 117 −369 −294 −249 — −11 −7944 −8987 −894 −1115 −701 −1378−9818 −9074 253(T −1822 −1611 −4151 −3676 −1688 −3491 −2844 186 −3366815 −670 −3264 −3577 −3075 −3294 −2693 2637 2187 −2655 −2324 254 — −149−500 233 43 −381 399 106 −626 210 −466 −720 275 394 45 96 359 117 −369−294 −249 — −11 −7944 −8987 −894 −1115 −701 −1378 −9818 −9071 254(M−3494 −2937 −5788 −5208 2737 −5472 −3898 −624 −4954 2288 2851 −5116−4665 −3807 −4466 −4768 −3340 −1435 −2676 −2586 255 — −149 −500 233 43−381 399 106 −626 210 −466 −720 275 394 45 96 359 117 −369 −294 −249 —−11 −7944 −8987 −894 −1115 −701 −1378 −9818 −9069 255(D −2671 −4634 37181448 −4812 −2395 −1863 −4839 −2290 −4667 −4121 −999 −2987 −1563 −3285−2280 −2777 −4278 −4793 −3731 256 — −149 −500 233 43 −381 399 106 −626210 −466 −720 275 394 45 96 359 117 −369 −294 −249 — −11 −7944 −8987−894 −1115 −701 −1378 −9818 −9066 256( −807 −1865 984 −295 −2038 −18502023 698 1219 −1817 −996 −567 −1940 −139 −647 −780 1016 −1409 2991 −1556257 — −149 −500 233 43 −381 399 106 −626 210 −466 −720 275 394 45 96 359117 −369 −294 −249 — −11 −7944 −8987 −894 −1115 −701 −1378 −9818 −9063257(C 2301 2673 −4116 −3625 −1761 −3338 −2704 1666 −3330 −1177 −798−3141 −3451 −3036 −3235 −2529 −1663 1516 −2564 −2191 258 — −149 −500 23343 −381 399 106 −626 210 −466 −720 275 394 45 96 359 117 −369 −294 −249— −11 −7944 −8987 −894 −1115 −701 −1378 −9818 −9061 258(F) −1716 −1417−4136 −3595 2444 −3534 −2588 1707 −3287 −928 −598 −3178 −3504 −2965−3167 −2682 1032 2265 −2368 −1993 259 — −149 −500 233 43 −381 399 106−626 210 −466 −720 275 394 45 96 359 117 −369 −294 −249 — −11 −7944−8987 −894 −1115 −701 −1378 −9818 −9058 259(E −2313 −4187 2435 2792−4402 −2263 −1610 −4323 −1844 −4194 −3514 −860 −2792 −1276 −2693 882−2382 −3790 −4388 −3377 260 — −149 −500 233 43 −381 399 106 −626 210−466 −720 275 394 45 96 359 117 −369 −294 −249 — −11 −7944 −8987 −894−1115 −701 −1378 −9818 −9055 260(E −1939 −3595 1643 2581 −3872 −2212−1304 −3690 −1146 −3580 −2792 −818 −2607 −925 2340 −1689 −1941 −3216−3731 −2921 261 — −149 −500 233 43 −381 399 106 −626 210 −466 −720 275394 45 96 359 117 −369 −294 −249 — −11 −7944 −8987 −894 −1115 −701 −1378−9818 −9053 261(I) −3202 −2787 −5004 −4996 −2836 −4384 −4440 3937 −4838−1815 −1871 −4704 −4600 −4683 −4704 −4353 −3280 −603 −3938 −3661 262 —−149 −500 233 43 −381 399 106 −626 210 −466 −720 275 394 45 96 359 117−369 −294 −249 — −11 −7944 −8987 −894 −1115 −701 −1378 −9818 −9050 262(H−1017 2728 −2493 −1992 −1270 −2240 3922 −987 −1659 529 −639 −1791 −2500−1540 −1774 784 −1071 −839 −1737 −1261 263 — −149 −500 233 43 −381 399106 −626 210 −466 −720 275 394 45 96 359 117 −369 −294 −249 — −11 −7944−8987 −894 −1115 −701 −1378 −9818 −9047 263(Q 741 −3277 2434 −357 −3577−2095 −1155 −3386 −1029 −3313 −2481 1522 −2449 2598 −1654 −1458 −1671−2910 −3496 −2688 264 — −149 −500 233 43 −381 399 106 −626 210 −466 −720275 394 45 96 359 117 −369 −294 −249 — −11 −7944 −8987 −894 −1115 −701−1378 −9818 −9044 264(I) −3202 −2787 −5004 −4996 −2836 −4384 −4440 3937−4838 −1815 −1871 −4704 −4600 −4683 −4704 −4353 −3280 −603 −3938 −3661265 — −149 −500 233 43 −381 399 106 −626 210 −466 −720 275 394 45 96 359117 −369 −294 −249 — −11 −7944 −8987 −894 −1115 −701 −1378 −9818 −9042265(Q −2715 −3506 −2454 −1838 −4264 −3140 −1326 −3747 2319 −3422 −2758−1861 −3215 3713 −73 −2577 −2482 −3480 −3261 −3082 266 — −149 −500 23343 −381 399 106 −626 210 −466 −720 275 394 45 96 359 117 −369 −294 −249— −11 −7944 −8987 −894 −1115 −701 −1378 −9818 −9039 266(H 766 −2665−1250 −679 −3083 −2257 3314 −2738 2115 −2633 −1790 −913 −2340 1628 −214−1286 −1299 −2357 −2720 −2207 267 — −149 −500 233 43 −381 399 106 −626210 −466 −720 275 394 45 96 359 117 −369 −294 −249 — −11 −7945 −8987−894 −1115 −701 −1378 −9818 −9036 267(A 1483 −2544 1329 1148 −2853 −1866−632 −2614 −278 −2555 −1651 1353 −2033 −189 1407 −900 −994 −2162 −2727−2019 268 — −149 −500 233 43 −381 399 106 −626 210 −466 −720 275 394 4596 359 117 −369 −294 −249 — −11 −7945 −8987 −894 −1115 −701 −1378 −9818−9033 268(A 3609 −2508 −4184 −4493 −4592 −2737 −3989 −4421 −4496 −4701−4051 −3440 −3474 −4171 −4253 −2294 −2487 −3536 −4484 −4643 269 — −149−500 233 43 −381 399 106 −626 210 −466 −720 275 394 45 96 359 117 −369−294 −249 — −11 −7945 −8987 −894 −1115 −701 −1378 −9818 −9031 269(R−2965 −3547 −3408 −2282 −4379 −3379 −1388 −3839 12 −3467 −2835 −2157−3384 1874 3734 −2857 −2671 −3611 −3250 −3161 270 — −149 −500 233 43−381 399 106 −626 210 −466 −720 275 394 45 96 359 117 −369 −294 −249 —−1308 −7945 −761 −894 −1115 −701 −1378 −9818 −9028 270(N −1039 −2562 5862367 −2858 −1300 −470 −2699 −385 −2652 −1895 2515 −1724 −111 −973 −813−1067 −2247 −2807 −2007 271 — −149 −500 235 43 −381 399 106 −626 210−466 −720 275 394 45 96 359 117 −369 −294 −249 — −714 −1382 −7703 −151−3331 −2609 −258 −9818 −9025 271(N −622 −1477 −200 −357 −2707 2061 −999−2606 −952 −2696 −1925 2838 −1767 −722 −1374 −664 −868 −1957 −2760 −2210273 — −149 −500 233 43 −381 399 106 −626 210 −466 −720 275 394 45 96 359117 −369 −294 −249 — −24 −6661 −7703 −894 −1115 −156 −3286 −9818 −9022272(S) −828 −2001 −805 1032 −2258 −1836 −533 −1931 −149 −2007 −1158 −547−1941 −119 1234 1440 1026 880 −2282 −1677 274 — −149 −500 233 43 −381399 106 −626 210 −466 −720 275 394 45 96 359 117 −369 −294 −249 — −12−7945 −8987 −894 −1115 −701 −1378 −9818 −9020 273(N −1190 −2573 1355−283 −2861 654 −809 −2615 −530 −2616 −1754 2375 −2165 −395 −1071 −10621012 −2205 −2829 1781 275 — −149 −500 233 43 −381 399 106 −626 210 −466−720 275 394 45 96 359 117 −369 −294 −249 — −12 −7945 −8987 −894 −1115−701 −1378 −9818 −9017 274(Q 645 −2328 1160 −107 −2646 495 −476 −2397−72 −2344 −1425 1283 −1901 1657 1361 −730 −798 −1950 −2514 −1827 276 —−149 −500 233 43 −381 399 106 −626 210 −466 −720 275 394 45 96 359 117−369 −294 −249 — −12 −7945 −8987 −894 −1115 −701 −1378 −9818 −9014 275(M−816 −2072 1026 1269 −2307 −1806 −491 649 −121 −2050 1968 1387 −1908 −67−614 −740 927 −1644 −2309 −1678 277 — −149 −500 233 43 −381 399 106 −626210 −466 −720 275 394 45 96 359 117 −369 −294 −249 — −12 −7945 −8987−894 −1115 −701 −1378 −9818 −9011 276(C 897 2636 −1616 1312 −2623 1770−1334 −2281 −1102 −2451 −1631 −1244 −2278 −1004 −1507 −1024 1250 −1839−2782 −2281 278 — −149 −500 233 43 −381 399 106 −626 210 −466 −720 275394 45 96 359 117 −369 −294 −249 — −242 −7945 −2754 −894 −1115 −701−1378 −9818 −9008 277(S) −911 −1183 −1682 1126 −1300 −2191 −1054 1565−1062 −1045 −424 −1278 −2298 −937 −1360 1632 −874 1229 −1746 −1317 279 —−149 −500 233 43 −381 399 106 −626 210 −466 −720 275 394 45 96 359 117−369 −294 −249 — −13 −7716 −8758 −894 −1115 −374 −2130 −9818 −9006 278(R−2689 −3297 −3482 −2098 −4001 −3278 −1187 1210 1825 −3091 −2443 −1979−3214 −777 3313 −2610 −2385 −3099 −3035 −2916 280 — −149 −500 233 43−381 399 106 −626 210 −466 −720 275 394 45 96 359 117 −369 −294 −249 —−12 −7945 −8987 −894 −1115 −701 −1378 −9818 −9003 279(P) −4497 −4117−4899 −5251 −5560 −4139 −4798 −6328 −5454 −5976 −5741 −5026 4302 −5328−5104 −4798 −4844 −5739 −4665 −5484 281 — −149 −500 233 43 −381 399 106−626 210 −466 −720 275 394 45 96 359 117 −369 −294 −249 — −12 −7945−8987 −894 −1115 −701 −1378 −9818 −9000 280(R 778 −2256 −849 1049 1188−1910 −526 −2252 1217 −2239 −1363 −569 −1997 −87 2088 −847 −872 −1870−2431 −1819 282 — −149 −500 233 43 −381 399 106 −626 210 −466 −720 275394 45 96 359 117 −369 −294 −249 — −12 −7945 −8987 −894 −1115 −701 −1378−9818 −8997 281( −4593 −3601 −4995 −5296 213 −4817 −1247 −3585 −4805−2925 −3000 −3610 −4749 −3723 −4255 −4202 −4477 −3731 5803 2567 283 —−149 −500 233 43 −381 399 106 −626 210 −466 −720 275 394 45 96 359 117−369 −294 −249 — −12 −7945 −8987 −894 −1115 −701 −1378 −9818 −8994282(P) −4497 −4117 −4899 −5251 −5560 −4139 −4798 −6328 −5454 −5976 −5741−5026 4302 −5328 −5104 −4798 −4844 −5739 −4665 −5484 284 — −149 −500 23343 −381 399 106 −626 210 −466 −720 275 394 45 96 359 117 −369 −294 −249— −12 −7945 −8987 −894 −1115 −701 −1378 −9818 −8992 283(M −2922 −2503−5243 −4802 −1395 −4799 −3922 1630 −4451 −67 4721 −4580 −4460 −3821−4212 −4136 −2877 −524 −2992 −2887 285 — −149 −500 233 43 −381 399 106−626 210 −466 −720 275 394 45 96 359 117 −369 −294 −249 — −12 −7945−8987 −894 −1115 −701 −1378 −9818 −8989 284(I) −2495 −2001 −5129 −4756−2240 −4897 −4552 2929 −4659 812 −991 −4553 −4608 −4412 −4697 −4228−2473 2322 −3865 −3522 286 — −149 −500 233 43 −381 399 106 −626 210 −466−720 275 394 45 96 359 117 −369 −294 −249 — −12 −7945 −8987 −894 −1115−701 −1378 −9818 −8986 285(I) −2456 −1959 −5125 −4808 −2579 −4919 −49003028 −4754 −1349 −1292 −4605 −4688 −4684 −4898 −4291 −2452 2714 −4288−3786 287 — −149 −500 233 43 −381 399 106 −626 210 −466 −720 275 394 4596 359 117 −369 −294 −249 — −12 −7945 −8987 −894 −1115 −701 −1378 −9818−8983 286(M 848 −1916 −4474 −3859 1726 −3859 −2665 −466 −3512 2254 2464−3496 −3662 −2906 −3258 −2991 −2116 −895 −2138 −1962 288 — −149 −500 23343 −381 399 106 −626 210 −466 −720 275 394 45 96 359 117 −369 −294 −249— −12 −7945 −8987 −894 −1115 −701 −1378 −9818 −8980 287(R −4488 −4181−4789 −4318 −5193 −4148 −3436 −5568 −2393 −5152 −4748 −4156 −4479 −32864202 −4614 −4467 −5273 −4267 −4649 289 — −149 −500 233 43 −381 399 106−626 210 −466 −720 275 394 45 96 359 117 −369 −294 −249 — −12 −7945−8987 −894 −1115 −701 −1378 −9818 −8977 288(T −1068 −1511 −3017 −2766−2440 −2076 −2321 −1926 −2515 691 −1630 −2213 −2655 −2340 −2580 984 3190−1612 −2890 −2538 290 — −149 −500 233 43 −381 399 106 −626 210 −466 −720275 394 45 96 359 117 −369 −294 −249 — −12 −7945 −8987 −894 −1115 −701−1378 −9818 −8974 289(P) −4497 −4117 −4899 −5251 −5560 −4139 −4798 −6328−5454 −5976 −5741 −5026 4302 −5328 −5104 −4798 −4844 −5739 −4665 −5484291 — −149 −500 233 43 −381 399 106 −626 210 −466 −720 275 394 45 96 359117 −369 −294 −249 — −12 −7945 −8987 −894 −1115 −701 −1378 −9818 −8972290(K −4125 −4091 −4017 −3615 −5101 −3960 −2958 −5182 3972 −4825 −4345−3552 −4249 −2709 −1809 −4154 −4044 −4895 −4132 −4389 292 — −149 −500233 43 −381 399 106 −626 210 −466 −720 275 394 45 96 359 117 −369 −294−249 — −12 −7945 −8987 −894 −1115 −701 −1378 −9818 −8969 291(G −4088−3924 −4774 −5139 −5615 3825 −4753 −6303 −5453 −6014 −5662 −4812 −4539−5232 −5106 −4370 −4472 −5527 −4696 −5561 293 — −149 −500 233 43 −381399 106 −626 210 −466 −720 275 394 45 96 359 117 −369 −294 −249 — −12−7945 −8987 −894 −1115 −701 −1378 −9818 −8966 292( −3761 −3778 −4018−3442 −2596 −3886 −2358 −4281 1706 −3948 −3562 −3262 −4095 −2403 −1546−3781 −3651 −4139 5825 −2093 294 — −149 −500 233 43 −381 399 106 −626210 −466 −720 275 394 45 96 359 117 −369 −294 −249 — −12 −7945 −8987−894 −1115 −701 −1378 −9818 −8963 293(T −1328 −1922 −3470 −3733 −43072277 −3460 −4117 −3841 −4377 −3512 −2726 −2930 −3472 −3723 −1571 3260−3014 −4415 −4352 295 — −149 −500 233 43 −381 399 106 −626 210 −466 −720275 394 45 96 359 117 −369 −294 −249 — −12 −7945 −8987 −894 −1115 −701−1378 −9818 −8960 294(C −1973 4291 −4548 −4851 −4702 3097 −4084 −4671−4689 −4886 −4115 −3509 −3445 −4310 −4354 −2238 −2433 −3616 −4524 −4782296 — −149 −500 233 43 −381 399 106 −626 210 −466 −720 275 394 45 96 359117 −369 −294 −249 — −12 −7945 −8987 −894 −1115 −701 −1378 −9818 −8957295(P) −4497 −4117 −4899 −5251 −5560 −4139 −4798 −6328 −5454 −5976 −5741−5026 4302 −5328 −5104 −4798 −4844 −5739 −4665 −5484 297 — −149 −500 23343 −381 399 106 −626 210 −466 −720 275 394 45 96 359 117 −369 −294 −249— −12 −7945 −8987 −894 −1115 −701 −1378 −9818 −8954 296(K −2049 −32061214 −1125 −3777 −2660 −1057 −3338 3118 −3117 −2350 −1305 −2771 −6351683 −1896 −1900 −2990 −3089 −2711 298 — −149 −500 233 43 −381 399 106−626 210 −466 −720 275 394 45 96 359 117 −369 −294 −249 — −12 −7945−8987 −894 −1115 −701 −1378 −9818 −8951 297(Y −3980 −3319 −4251 999 2912−4528 −1135 −3159 −4198 −2674 −2627 −3261 −4474 −3325 −3891 −3769 −3878−3246 −434 3896 299 — −149 −500 233 43 −381 399 106 −626 210 −466 −720275 394 45 96 359 117 −369 −294 −249 — −1892 −7945 −465 −894 −1115 −701−1378 −9818 −8948 298(N −682 −1389 −43 −192 −1821 −1114 −672 −2026 −553−2169 −1573 3502 −1613 −485 −863 −706 −866 −1616 −1943 −1374 300 — −149−500 233 43 −381 399 106 −626 210 −466 −720 275 394 45 96 359 117 −369−294 −249 — −35 −6088 −7130 −894 −1115 −2832 −218 −9818 −8945 299(D−1183 −2113 3476 202 −2559 −1197 −709 −2583 −900 −2640 −2095 −138 −1700−471 −1494 −1021 −1294 −2203 −2437 −1969 301 — −149 −500 233 43 −381 399106 −626 210 −466 −720 275 394 45 96 359 117 −369 −294 −249 — −35 −6088−7130 −894 −1115 −2832 −218 −9818 −8943 300( −2006 −1640 −2485 −2452 132−2122 −859 −1689 −1966 −1425 −1294 −2093 −2439 −1935 −1852 −2230 −2075−1731 5734 501 302 — −149 −500 233 43 −381 399 106 −626 210 −466 −720275 394 45 96 359 117 −369 −294 −249 — −35 −6088 −7130 −894 −1115 −2832−218 −9818 −8940 301(S) 87 −526 −885 −918 −1797 −699 −997 −1679 −970−1948 −1267 −663 −1335 −874 −1147 2826 −252 −1082 −2036 −1577 303 — −149−500 233 43 −381 399 106 −626 210 −466 −720 275 394 45 96 359 117 −369−294 −249 — −35 −6088 −7130 −894 −1115 −2832 −218 −9818 −8937 302(G −822−1159 −1384 −1565 −2531 3361 −1634 −2586 −1803 −2721 −2161 −1396 −1832−1670 −1866 −1023 −1160 −1997 −2255 −2352 304 — −149 −500 233 43 −381399 106 −626 210 −466 −720 275 394 45 96 359 117 −369 −294 −249 — −35−6088 −7130 −894 −1115 −2832 −218 −9818 −8934 303(P) −1003 −1278 −1425−1532 −2259 −1370 −1531 −2247 −1572 −2349 −1911 −1434 3795 −1555 −1648−1199 −1287 −1861 −2108 −2096 305 — −149 −500 233 43 −381 399 106 −626210 −466 −720 275 394 45 96 359 117 −369 −294 −249 — −35 −6088 −7130−894 −1115 −2832 −218 −9818 −8931 304(K −1075 −1727 −849 −488 −2222−1560 −298 −1928 3141 −1906 −1299 −589 −1788 39 576 −1050 −1018 −1673−1848 −1572 306 — −149 −500 233 43 −381 399 106 −626 210 −466 −720 275394 45 96 359 117 −369 −294 −249 — −35 −6088 −7130 −894 −1115 −133 −3510−9818 −8928 305(V −2351 −1948 −4836 −4325 1729 −4359 −3437 1662 −40741144 −429 −4011 −4122 −3586 −3910 −3565 −2297 2576 −2861 −2632 307 —−149 −500 233 43 −381 399 106 −626 210 −466 −720 275 394 45 96 359 117−369 −294 −249 — −12 −7945 −8987 −894 −1115 −701 −1378 −9818 −8925 306(D−2623 −4424 3671 −647 −4716 −2401 −1896 −4807 −2315 −4650 −4093 1964−2996 −1602 −3278 −2267 −2747 −4224 −4722 −3696 308 — −149 −500 233 43−381 399 106 −626 210 −466 −720 275 394 45 96 359 117 −369 −294 −249 —−12 −7945 −8987 −894 −1115 −701 −1378 −9818 −8922 307(G −4088 −3924−4774 −5139 −5615 3825 −4753 −6303 −5453 −6014 −5662 −4812 −4539 −5232−5106 −4370 −4472 −5527 −4696 −5561 309 — −149 −500 233 43 −381 399 106−626 210 −466 −720 275 394 45 96 359 117 −369 −294 −249 — −1892 −7945−465 −894 −1115 −701 −1378 −9818 −8919 308(K −1075 −1727 −849 −488 −2222−1560 −298 −1928 3141 −1906 −1299 −589 −1788 39 576 −1050 −1018 −1673−1848 −1572 310 — −149 −500 233 43 −381 399 106 −626 210 −466 −720 275394 45 96 359 117 −369 −294 −249 — −35 −6088 −7130 −894 −1115 −2832 −218−9818 −8916 309(G −822 −1159 −1384 −1565 −2531 3361 −1634 −2586 −1803−2721 −2161 −1396 −1832 −1670 −1866 −1023 −1160 −1997 −2255 −2352 311 —−149 −500 233 43 −381 399 106 −626 210 −466 −720 275 394 45 96 359 117−369 −294 −249 — −35 −6088 −7130 −894 −1115 −133 −3510 −9818 −8913 310(M−972 −1126 −2062 −1461 −1092 −2307 2087 −624 1939 525 2294 −1457 −2364−1036 −1244 −1332 −906 985 −1529 −1141 312 — −149 −500 233 43 −381 399106 −626 210 −466 −720 275 394 45 96 359 117 −369 −294 −249 — −12 −7945−8987 −894 −1115 −701 −1378 −9818 −8910 311(K −1820 −2479 −2019 −15581878 −2659 −1288 −2471 2648 −2477 −1862 −1639 2280 −1101 −838 −1862−1798 −2256 −2259 −1515 313 — −149 −500 233 43 −381 399 106 −626 210−466 −720 275 394 45 96 359 117 −369 −294 −249 — −12 −7945 −8987 −894−1115 −701 −1378 −9818 −8907 312(T −1151 −994 −3207 −2614 −1014 −2726−1631 1486 −2292 872 −195 1131 −2765 −1990 −2222 −1813 1899 1286 −1587−1232 314 — −149 −500 233 43 −381 399 106 −626 210 −466 −720 275 394 4596 359 117 −369 −294 −249 — −12 −7945 −8987 −894 −1115 −701 −1378 −9818−8904 313(E −4205 −4417 −2343 3901 −5349 −3698 −3534 −5837 −3838 −5561−5237 −3039 −4218 −3453 −4201 −4072 −4352 −5409 −4640 −4860 315 — −149−500 233 43 −381 399 106 −626 210 −466 −720 275 394 45 96 359 117 −369−294 −249 — −12 −7945 −8987 −894 −1115 −701 −1378 −9818 −8901 314(G−2817 −3261 −2719 −3002 −3965 3464 2847 −5005 −3386 −4897 −4328 −2988−3770 −3306 −3516 −2944 −3148 −4263 −3982 −3566 316 — −149 −500 233 43−381 399 106 −626 210 −466 −720 275 394 45 96 359 117 −369 −294 −249 —−12 −7945 −8987 −894 −1115 −701 −1378 −9818 −8898 315(F) −1106 −1561−3154 −2946 2579 −2093 −2290 −2229 −2773 −2503 −1842 −2289 −2698 −2501−2812 2488 1579 −1836 −2597 −1956 317 — −149 −500 233 43 −381 399 106−626 210 −466 −720 275 394 45 96 359 117 −369 −294 −249 — −12 −7945−8987 −894 −1115 −701 −1378 −9818 −8895 316( −4550 −3570 −5043 −53483560 −4834 −1253 −3407 −4915 −2729 −2820 −3625 −4750 −3739 −4322 −4199−4435 −3608 4998 679 318 — −149 −500 233 43 −381 399 106 −626 210 −466−720 275 394 45 96 359 117 −369 −294 −249 — −12 −7945 −8987 −894 −1115−701 −1378 −9818 −8892 317(R −4488 −4181 −4789 −4318 −5193 −4148 −3436−5568 −2393 −5152 −4748 −4156 −4479 −3286 4202 −4614 −4467 −5273 −4267−4649 319 — −149 −500 233 43 −381 399 106 −626 210 −466 −720 275 394 4596 359 117 −369 −294 −249 — −12 −7945 −8987 −894 −1115 −701 −1378 −9818−8889 318(A 3015 −1667 −3723 −3946 −4169 −1935 −3415 −3952 −3869 −4231−3312 −2607 −2729 −3434 −3685 1976 −1516 −2782 −4395 −4270 320 — −149−500 233 43 −381 399 106 −626 210 −466 −720 275 394 45 96 359 117 −369−294 −249 — −12 −7945 −8987 −894 −1115 −701 −1378 −9818 −8886 319(H−4836 −4275 −4356 −4629 −3663 −4242 5422 −5932 −4492 −5436 −5298 −4579−4696 −4620 −4352 −5005 −5030 −5648 −3750 −3259 321 — −149 −500 233 43−381 399 106 −626 210 −466 −720 275 394 45 96 359 117 −369 −294 −249 —−12 −7945 −8987 −894 −1115 −701 −1378 −9818 −8883 320(Q −4207 −4117−3531 −3731 −4752 −3930 −3721 −5554 −3395 −5179 −4897 −3823 −4399 4556−3405 −4301 −4380 −5208 −4301 −4384 322 — −149 −500 233 43 −381 399 106−626 210 −466 −720 275 394 45 96 359 117 −369 −294 −249 — −12 −7945−8987 −894 −1115 −701 −1378 −9818 −8880 321(V −2838 −2616 −4834 −4880−3213 −3955 −4416 −610 −4757 −2310 −2253 −4383 −4345 −4643 −4642 −3732−3007 3763 −4157 −3886 323 — −149 −500 233 43 −381 399 106 −626 210 −466−720 275 394 45 96 359 117 −369 −294 −249 — −12 −7945 −8987 −894 −1115−701 −1378 −9818 −8877 322(P) −4497 −4117 −4899 −5251 −5560 −4139 −4798−6328 −5454 −5976 −5741 −5026 4302 −5328 −5104 −4798 −4844 −5739 −4665−5484 324 — −149 −500 233 43 −381 399 106 −626 210 −466 −720 275 394 4596 359 117 −369 −294 −249 — −12 −7945 −8987 −894 −1115 −701 −1378 −9818−8873 323(L) −3647 −3060 −5937 −5371 −1118 −5682 −4332 −610 −5087 29962562 −5429 −4784 −3924 −4592 −5073 −3493 −1434 −2915 −3081 325 — −149−500 233 43 −381 399 106 −626 210 −466 −720 275 394 45 96 359 117 −369−294 −249 — −12 −7945 −8987 −894 −1115 −701 −1378 −9818 −8870 324(A 1628−2000 −1147 −671 −2849 708 −956 −2576 1413 −2602 −1707 −874 1246 −539−1044 862 −977 −2054 −2809 −2207 326 — −149 −500 233 43 −381 399 106−626 210 −466 −720 275 394 45 96 359 117 −369 −294 −249 — −12 −7945−8987 −894 −1115 −701 −1378 −9818 −8867 325(G −994 −1140 −2933 −2481−1432 1651 −1741 −844 −2217 1593 −640 −2068 −2570 −1955 −2226 912 −10961103 −1926 −1575 327 — −149 −500 233 43 −381 399 106 −626 210 −466 −720275 394 45 96 359 117 −369 −294 −249 — −12 −7945 −8987 −894 −1115 −701−1378 −9818 −8864 326(M 1630 −1391 944 −805 −1486 −2021 −819 −1063 −696342 2038 −972 −2133 −594 −1070 829 −812 −889 −1808 −1343 328 — −149 −500233 43 −381 399 106 −626 210 −466 −720 275 394 45 96 359 117 −369 −294−249 — −12 −7945 −8987 −894 −1115 −701 −1378 −9818 −8861 327(R 741 −2275−1345 −792 −2855 −2120 2241 −2529 −225 −2528 −1693 −987 −2298 −476 2769943 −1193 −2130 −2695 −2176 329 — −149 −500 233 43 −381 399 106 −626 210−466 −720 275 394 45 96 359 117 −369 −294 −249 — −12 −7945 −8987 −894−1115 −701 −1378 −9818 −8858 328(E −921 −2389 1203 1772 −2695 −1817 −532−2446 1276 −2398 −1488 −451 −1950 −84 −661 −792 1210 −2005 −2575 1454330 — −149 −500 233 43 −381 399 106 −626 210 −466 −720 275 394 45 96 359117 −369 −294 −249 — −12 −7945 −8987 −894 −1115 −701 −1378 −9818 −8855329(N −1665 −3235 1720 −369 −3518 −2098 2328 −3335 −1031 −3275 −24502949 −2451 −767 −1649 −1460 1173 −2871 −3460 −2660 331 — −149 −500 23343 −381 399 106 −626 210 −466 −720 275 394 45 96 359 117 −369 −294 −249— −12 −7945 −8987 −894 −1115 −701 −1378 −9818 −8852 330(M −984 −1840−1021 1102 −2105 −1976 −854 −1713 −582 −1892 2223 −850 1910 −518 −1007−1020 1988 −1453 −2293 −1758 332 — −149 −500 233 43 −381 399 106 −626210 −466 −720 275 394 45 96 359 117 −369 −294 −249 — −12 −7945 −8987−894 −1115 −701 −1378 −9818 −8849 331(A 2196 −2790 −511 1218 −3438 973−1226 −3215 −1068 −3198 −2356 1800 −2422 −839 −1642 −1356 −1536 −2702−3401 −2670 333 — −149 −500 233 43 −381 399 106 −626 210 −466 −720 275394 45 96 359 117 −369 −294 −249 — −12 −7945 −8987 −894 −1115 −701 −1378−9818 −8845 332(H −1254 −2578 −716 −424 −2897 −2040 3715 −2651 −343−2622 −1770 1388 −2228 1875 −752 −1137 1164 −2249 −2782 −2139 334 — −149−500 233 43 −381 399 106 −626 210 −466 −720 275 394 45 96 359 117 −369−294 −249 — −12 −7945 −8987 −894 −1115 −701 −1378 −9818 −8842 333(L)−2624 −2340 −4474 −3875 1811 −4126 −2401 −789 −3050 2542 −178 −3525−3908 −2863 1521 −3305 −2528 −1300 −1886 −1260 335 — −149 −500 233 43−381 399 106 −626 210 −466 −720 275 394 45 96 359 117 −369 −294 −249 —−12 −7945 −8987 −894 −1115 −701 −1378 −9818 −8839 334(N −994 −2499 11681208 −2810 −1843 −590 −2571 1159 −2510 −1599 1604 1101 1558 −751 −854−943 −2117 −2678 −1972 336 — −149 −500 233 43 −381 399 106 −626 210 −466−720 275 394 45 96 359 117 −369 −294 −249 — −12 −7945 −8987 −894 −1115−701 −1378 −9818 −8836 335(Q −1074 −1608 −1378 1055 −1583 −2212 −948−1034 −735 1334 −653 −1095 −2304 2285 −1076 −1227 −1014 962 −1974 −1519337 — −149 −500 233 43 −381 399 106 −626 210 −466 −720 275 394 45 96 359117 −369 −294 −249 — −12 −7945 −8987 −894 −1115 −701 −1378 −9818 −8833336(L) −3687 −3085 −5735 −5323 1918 −5462 −3361 −783 −5056 2956 −82−4983 −4746 −3886 −4547 −4848 −3542 −1585 −2287 −1717 338 — −149 −500233 43 −381 399 106 −626 210 −466 −720 275 394 45 96 359 117 −369 −294−249 — −12 −7945 −8987 −894 −1115 −701 −1378 −9818 −8830 337(E −1470−2699 −964 2371 −3064 −2232 −901 −2597 2215 −2668 −1868 −905 −2396 −486−559 −1359 −1400 909 −2856 −2297 339 — −149 −500 233 43 −381 399 106−626 210 −466 −720 275 394 45 96 359 117 −369 −294 −249 — −12 −7945−8987 −894 −1115 −701 −1378 −9818 −8827 338(E 690 −2696 1523 1869 −2999734 −738 −2770 1285 −2707 −1812 −539 −2120 −303 −973 −1012 −1128 −2313−2880 −2153 340 — −149 −500 233 43 −381 399 106 −626 210 −466 −720 275394 45 96 359 117 −369 −294 −249 — −12 −7945 −8987 −894 −1115 −701 −1378−9818 −8823 339( −5598 −4432 −5385 −5722 −3380 −4524 −4140 −5941 −5643−5318 −5354 −5427 −4938 −5474 −5178 −5909 −5751 −5890 6275 −2993 341 —−149 −500 233 43 −381 399 106 −626 210 −466 −720 275 394 45 96 359 117−369 −294 −249 — −12 −7945 −8987 −894 −1115 −701 −1378 −9818 −8820 340(M−3596 −3028 −5873 −5313 −1121 −5593 −4267 −607 −5011 2392 4057 −5338−4750 −3897 −4538 −4973 −3450 −1415 −2899 −3039 342 — −149 −500 233 43−381 399 106 −626 210 −466 −720 275 394 45 96 359 117 −369 −294 −249 —−12 −7945 −8987 −894 −1115 −701 −1378 −9818 −8817 341(K −991 −2413 −8181144 −2767 −1924 −530 −2487 1895 −2410 −1508 1562 −2015 −77 1221 −8691088 −2056 −2547 −1918 343 — −149 −500 233 43 −381 399 106 −626 210 −466−720 275 394 45 96 359 117 −369 −294 −249 — −12 −7945 −8987 −894 −1115−701 −1378 −9818 −8814 342(S) −1944 −2458 −3696 −4011 −4410 −2644 −3753−4675 −4191 −4807 −4070 −3198 −3384 −3886 −4051 3656 −2393 −3615 −4374−4307 344 — −149 −500 233 43 −381 399 106 −626 210 −466 −720 275 394 4596 359 117 −369 −294 −249 — −12 −7945 −8987 −894 −1115 −701 −1378 −9818−8811 343(Y −4791 −3935 −4914 −5231 −815 −4530 −2178 −4357 −5024 −3745−3807 −4206 −4772 −4328 −4584 −4677 −4837 −4435 −1477 4857 345 — −149−500 233 43 −381 399 106 −626 210 −466 −720 275 394 45 96 359 117 −369−294 −249 — −12 −7945 −8987 −894 −1115 −701 −1378 −9818 −8807 344(K−2113 −3150 −2249 −1388 −3797 −2829 −992 −3281 2710 −3026 −2265 1725−2831 1860 1625 −1985 −1911 −2964 −2962 −2675 346 — −149 −500 233 43−381 399 106 −626 210 −466 −720 275 394 45 96 359 117 −369 −294 −249 —−12 −7945 −8987 −894 −1115 −701 −1378 −9818 −8804 345(P) −2272 3432−4625 −4892 −4644 −2928 −4139 −4609 −4669 −4819 −4180 −3725 3909 −4404−4368 −2543 −2718 −3748 −4454 −4686 347 — −149 −500 233 43 −381 399 106−626 210 −466 −720 275 394 45 96 359 117 −369 −294 −249 — −12 −7945−8987 −894 −1115 −701 −1378 −9818 −8801 346(E −2460 −4036 −460 3371−4348 −2457 −1702 −4275 −1584 −4118 −3462 −1104 −2946 2051 −2090 −2167−2503 −3804 −4163 −3385 348 — −149 −500 233 43 −381 399 106 −626 210−466 −720 275 394 45 96 359 117 −369 −294 −249 — −12 −7945 −8987 −894−1115 −701 −1378 −9818 −8798 347(E −2181 −3963 1851 3002 −4213 −2236−1529 −4092 −1674 −3990 −3269 −843 −2732 −1182 −2455 −1882 1292 −3581−4185 −3235 349 — −149 −500 233 43 −381 399 106 −626 210 −466 −720 275394 45 96 359 117 −369 −294 −249 — −12 −7945 −8987 −894 −1115 −701 −1378−9818 −8794 348(L) −3686 −3084 −5725 −5318 2066 −5451 −3323 −791 −50502922 −90 −4961 −4743 −3882 −4541 −4834 −3541 −1590 −2260 −1671 350 —−149 −500 233 43 −381 399 106 −626 210 −466 −720 275 394 45 96 359 117−369 −294 −249 — −12 −7945 −8987 −894 −1115 −701 −1378 −9818 −8791349(F) −3772 −3147 −5332 −5198 4004 −5042 −2246 −1256 −4859 1259 −621−4264 −4667 −3786 −4369 −4411 −3663 −1931 −1412 −419 351 — −149 −500 23343 −381 399 106 −626 210 −466 −720 275 394 45 96 359 117 −369 −294 −249— −12 −7945 −8987 −894 −1115 −701 −1378 −9818 −8788 350(D −2611 −44163402 −640 −4705 −2395 −1885 −4789 −2297 −4633 −4071 2681 −2988 −1589−3255 −2256 −2733 −4207 −4711 −3684 352 — −149 −500 233 43 −381 399 106−626 210 −466 −720 275 394 45 96 359 117 −369 −294 −249 — −12 −7945−8987 −894 −1115 −701 −1378 −9818 −8785 351(E 2436 −2868 −924 2744 −4080−2309 −2015 −3815 −2053 −3929 −3209 −1413 −2875 −1718 −2576 −1853 −2106−3206 −4090 −3471 353 — −149 −500 233 43 −381 399 106 −626 210 −466 −720275 394 45 96 359 117 −369 −294 −249 — −12 −7945 −8987 −894 −1115 −701−1378 −9818 −8781 352(H 692 −2743 2175 −223 −3038 −1936 2515 −2810 −480−2751 −1863 1409 −2154 1594 −1031 −1057 −1179 −2357 −2927 −2196 354 —−149 −500 233 43 −381 399 106 −626 210 −466 −720 275 394 45 96 359 117−369 −294 −249 — −12 −7945 −8987 −894 −1115 −701 −1378 −9818 −8778 353(G−2929 −3168 −3518 −3782 −1975 3489 −2803 −4394 −4019 −4184 −3856 −3400−3940 −3733 −3967 −3094 −3258 −3950 −2519 2220 355 — −149 −500 233 43−381 399 106 −626 210 −466 −720 275 394 45 96 359 117 −369 −294 −249 —−12 −7945 −8987 −894 −1115 −701 −1378 −9818 −8775 354(S) 743 −1505 −1390−843 −1747 −1981 −884 −1345 −674 588 −830 −999 −2148 −615 1093 1645 1025−1123 −2016 −1540 356 — −149 −500 233 43 −381 399 106 −626 210 −466 −720275 394 45 96 359 117 −369 −294 −249 — −12 −7945 −8987 −894 −1115 −701−1378 −9818 −8771 355(P) −2511 −2204 −4688 −4170 −1213 −4215 −3207 1516−3824 2221 −98 −3895 2348 −3271 −3624 −3424 −2456 −677 −2586 −2462 357 —−149 −500 233 43 −381 399 106 −626 210 −466 −720 275 394 45 96 359 117−369 −294 −249 — −12 −7945 −8987 −894 −1115 −701 −1378 −9818 −8768 356(K−1302 −1414 −2419 −1840 −1577 −2693 −1530 1325 2435 −1189 −660 −1855−2761 −1446 −1616 −1749 1313 1240 −2101 −1697 358 — −149 −500 233 43−381 399 106 −626 210 −466 −720 275 394 45 96 359 117 −369 −294 −249 —−12 −7945 −8987 −894 −1115 −701 −1378 −9818 −8765 357(E 687 −2542 −6231957 −2905 −1944 −710 −2641 1433 −2592 −1707 −604 1914 −274 −748 −998−1082 −2205 −2761 −2094 359 — −149 −500 233 43 −381 399 106 −626 210−466 −720 275 394 45 96 359 117 −369 −294 −249 — −12 −7945 −8987 −894−1115 −701 −1378 −9818 −8762 358(E −2040 −3771 1647 2163 −4056 1964−1435 −3921 −1508 −3821 −3060 −809 −2658 −1075 −2248 864 −2081 −3410−4011 −3098 360 — −149 −500 233 43 −381 399 106 −626 210 −466 −720 275394 45 96 359 117 −369 −294 −249 — −12 −7945 −8987 −894 −1115 −701 −1378−9818 −8758 359(I) −2526 −2113 −4983 −4447 1598 −4503 −3494 2404 −41861749 −242 −4162 −4188 −3576 −3962 −3711 −2456 1420 −2790 −2649 361 —−149 −500 233 43 −381 399 106 −626 210 −466 −720 275 394 45 96 359 117−369 −294 −249 — −12 −7945 −8987 −894 −1115 −701 −1378 −9818 −8755 360(R−1519 −2765 −1433 1043 −3230 −2362 −786 −2853 1407 −2712 −1878 −1010−2424 −346 2271 −1399 2090 −2477 −2766 −2295 362 — −149 −500 233 43 −381399 106 −626 210 −466 −720 275 394 45 96 359 117 −369 −294 −249 — −12−7945 −8987 −894 −1115 −701 −1378 −9818 −8752 361(A 2266 −3817 1712 2253−4133 −2221 −1507 −3996 −1626 −3910 −3174 −845 −2706 −1158 −2386 −1834−2166 −3485 −4107 −3184 363 — −149 −500 233 43 −381 399 106 −626 210−466 −720 275 394 45 96 359 117 −369 −294 −249 — −12 −7945 −8987 −894−1115 −701 −1378 −9818 −8748 362(F) −1042 −885 −3196 −2582 2439 −25712436 1238 −2213 706 10 −2148 −2609 −1856 −2072 −1653 1024 −245 −1243−832 364 — −149 −500 233 43 −381 399 106 −626 210 −466 −720 275 394 4596 359 117 −369 −294 −249 — −12 −7945 −8987 −894 −1115 −701 −1378 −9818−8745 363(M 2115 −1084 −3069 −2501 −1009 −2553 −1611 −411 −2186 950 2374−2167 −2680 −1891 −2150 −1666 1057 −397 −1620 −1292 365 — −149 −500 23343 −381 399 106 −626 210 −466 −720 275 394 45 96 359 117 −369 −294 −249— −12 −7945 −8987 −894 −1115 −701 −1378 −9818 −8741 364(P) −4497 −4117−4899 −5251 −5560 −4139 −4798 −6328 −5454 −5976 −5741 −5026 4302 −5328−5104 −4798 −4844 −5739 −4665 −5484 366 — −149 −500 233 43 −381 399 106−626 210 −466 −720 275 394 45 96 359 117 −369 −294 −249 — −12 −7945−8987 −894 −1115 −701 −1378 −9818 −8738 365(K −1362 −2752 −891 1110−3142 −2149 −769 −2837 2560 −2727 −1865 −782 1373 1618 −441 −1221 −1281−2420 −2829 −2241 367 — −149 −500 233 43 −381 399 106 −626 210 −466 −720275 394 45 96 359 117 −369 −294 −249 — −12 −7945 −8987 −894 −1115 −701−1378 −9818 −8735 366(G 1022 −1909 −2732 −2555 −3858 2953 −2403 −3572−1903 −3702 −2863 −2142 −2736 −2152 1711 −1431 −1592 −2728 −3841 −3572368 — −149 −500 233 43 −381 399 106 −626 210 −466 −720 275 394 45 96 359117 −369 −294 −249 — −12 −7945 −8987 −894 −1115 −701 −1378 −9818 −8731367(E −1926 −3649 1536 2753 −3890 −2165 −1327 −3735 −1325 −3640 −28511567 −2586 −953 −2024 −1665 1092 −3244 −3826 −2947 369 — −149 −500 23343 −381 399 106 −626 210 −466 −720 275 394 45 96 359 117 −369 −294 −249— −12 −7945 −8987 −894 −1115 −701 −1378 −9818 −8728 368(K −2153 −2373−3052 −2232 −1767 −3262 −1649 −1215 3030 859 2514 −2219 −3217 −1370 −831−2425 −2024 −1487 −2493 −2241 370 — −149 −500 233 43 −381 399 106 −626210 −466 −720 275 394 45 96 359 117 −369 −294 −249 — −12 −7945 −8987−894 −1115 −701 −1378 −9818 −8725 369(R −4488 −4181 −4789 −4318 −5193−4148 −3436 −5568 −2393 −5152 −4748 −4156 −4479 −3286 4202 −4614 −4467−5273 −4267 −4649 371 — −149 −500 233 43 −381 399 106 −626 210 −466 −720275 394 45 96 359 117 −369 −294 −249 — −12 −7945 −8987 −894 −1115 −701−1378 −9818 −8721 370(M −3269 −2747 −5652 −5079 −1177 −5325 −4102 1525−4829 1255 4460 −5012 −4616 −3829 −4428 −4616 −3145 −974 −2895 −3004 372— −149 −500 233 43 −381 399 106 −626 210 −466 −720 275 394 45 96 359 117−369 −294 −249 — −12 −7945 −8987 −894 −1115 −701 −1378 −9818 −8718 371(G2030 −1651 −3665 −3855 −4195 2704 −3377 −3993 −3822 −4242 −3302 −2568−2705 −3371 −3670 1117 −1491 −2786 −4410 −4294 373 — −149 −500 233 43−381 399 106 −626 210 −466 −720 275 394 45 96 359 117 −369 −294 −249 —−12 −7945 −8987 −894 −1115 −701 −1378 −9818 −8714 372(A 2364 −1861 −1953−1763 −3466 −1952 −1976 −3199 −1760 −3331 −2471 −1666 −2522 1987 −20801936 −1374 −2468 −3555 −3102 374 — −149 −500 233 43 −381 399 106 −626210 −466 −720 275 394 45 96 359 117 −369 −294 −249 — −12 −7945 −8987−894 −1115 −701 −1378 −9818 −8711 373(N −1618 −2562 −1583 −1250 −3475−2356 −1296 −3134 −474 −3082 −2296 3378 −2657 −908 1726 −1605 1129 −2676−3159 −2725 375 — −149 −500 233 43 −381 399 106 −626 210 −466 −720 275394 45 96 359 117 −369 −294 −249 — −12 −7945 −8987 −894 −1115 −701 −1378−9818 −8707 374(P) −1913 −2274 −2279 −2086 −1517 −2783 2782 −2081 −1589560 −1612 −2058 3317 −1785 −1716 −2097 −1976 −2000 −2063 −1260 376 —−149 −500 233 43 −381 399 106 −626 210 −466 −720 275 394 45 96 359 117−369 −294 −249 — −12 −7945 −8987 −894 −1115 −701 −1378 −9818 −8704 375(H−929 −2010 −791 1272 −2044 −1913 2963 −1853 −298 −1959 −1145 1363 −2029−239 −766 −888 −872 799 −2186 1512 377 — −149 −500 233 43 −381 399 106−626 210 −466 −720 275 394 45 96 359 117 −369 −294 −249 — −12 −7945−8987 −894 −1115 −701 −1378 −9818 −8700 376(A 2877 −1669 −3800 −3976−4022 −1962 −3382 −3596 −3795 −3999 −3156 −2631 −2746 −3409 −3616 −13282512 −2627 −4284 −4151 378 — −149 −500 233 43 −381 399 106 −626 210 −466−720 275 394 45 96 359 117 −369 −294 −249 — −12 −7945 −8987 −894 −1115−701 −1378 −9818 −8697 377(N −3122 −3352 −2328 −2577 −596 −3446 −1619−3701 −2981 −3309 −3133 3888 −3831 −2693 −3130 −3026 −3247 −3561 −12702585 379 — −149 −500 233 43 −381 399 106 −626 210 −466 −720 275 394 4596 359 117 −369 −294 −249 — −12 −7945 −8987 −894 −1115 −701 −1378 −9818−8693 378(G −2018 −2692 −1922 −2271 −4544 3363 −2969 −4678 −3249 −4731−3990 1984 −3232 −2825 −3564 −2140 −2400 −3690 −4460 −4184 380 — −149−500 233 43 −381 399 106 −626 210 −466 −720 275 394 45 96 359 117 −369−294 −249 — −12 −7945 −8987 −894 −1115 −701 −1378 −9818 −8690 379(G−1257 −1874 −3207 −3523 −4341 3341 −3408 −4248 −3853 −4463 −3557 −2605−2866 −3402 −3760 1410 −1718 −3031 −4475 −4358 381 — −149 −500 233 43−381 399 106 −626 210 −466 −720 275 394 45 96 359 117 −369 −294 −249 —−12 −7945 −8987 −894 −1115 −701 −1378 −9818 −8687 380(Y −1236 −1100−3220 −2594 −757 −2737 −1473 −388 −2061 1865 −99 −2233 −2760 −1870 1132−1823 −1172 1244 −1376 2076 382 — −149 −500 233 43 −381 399 106 −626 210−466 −720 275 394 45 96 359 117 −369 −294 −249 — −12 −7945 −8987 −894−1115 −701 −1378 −9818 −8683 381(L) −2379 −2141 1254 −3407 −1292 −3975−2923 1518 −3405 2543 −203 −3359 −3842 −2943 −3392 −3194 −2319 −538−2579 −2378 383 — −149 −500 233 43 −381 399 106 −626 210 −466 −720 275394 45 96 359 117 −369 −294 −249 — −12 −7945 −8987 −894 −1115 −701 −1378−9818 −8679 382(R −1224 −1996 −1644 −1058 −2408 −2207 −1005 −2022 −378315 −1393 −1189 1416 −662 2668 937 −1215 −1747 −2459 −2006 384 — −149−500 233 43 −381 399 106 −626 210 −466 −720 275 394 45 96 359 117 −369−294 −249 — −288 −7945 −2519 −894 −1115 −701 −1378 −9818 −8676 383(R−1347 −2594 −872 1389 −3097 −2078 −754 −2768 −37 −2671 −1846 −784 −2259−333 2876 1137 −1287 −2364 −2765 −2230 385 — −149 −500 233 43 −381 399106 −626 210 −466 −720 275 394 45 96 359 117 −369 −294 −249 — −14 −7671−8713 −894 −1115 −1555 −600 −9818 −8672 384(N −1422 −3052 1734 1461−3326 980 −901 −3136 −759 −3056 −2213 1864 −2210 −500 −1385 1028 −1413−2660 −3236 −2429 386 — −149 −500 233 43 −381 399 106 −626 210 −466 −720275 394 45 96 359 117 −369 −294 −249 — −14 −7671 −8714 −894 −1115 −345−2232 −9818 −8669 385(L) −4119 −3542 −5389 −5357 −2027 −4767 −4358 −1609−5118 3293 −979 −5230 −4771 −4474 −4724 −5069 −4106 −2331 −3412 −3400387 — −149 −500 233 43 −381 399 106 −626 210 −466 −720 275 394 45 96 359117 −369 −294 −249 — −12 −7945 −8987 −894 −1115 −701 −1378 −9818 −8665386(K −1622 −2790 −1624 1030 −3260 −2461 −828 −2846 2708 −2716 −1905−1116 −2506 −393 1496 −1511 −1487 892 −2768 −2339 388 — −149 −500 233 43−381 399 106 −626 210 −466 −720 275 394 45 96 359 117 −369 −294 −249 —−12 −7945 −8987 −894 −1115 −701 −1378 −9818 −8662 387(M −1888 −1623−4198 −3600 −1092 −3572 −2482 −158 −3255 2140 2397 −3210 −3470 −2776−3059 −2699 1034 1479 −2114 −1890 389 — −149 −500 233 43 −381 399 106−626 210 −466 −720 275 394 45 96 359 117 −369 −294 −249 — −12 −7945−8987 −894 −1115 −701 −1378 −9818 −8658 388(P) −4497 −4117 −4899 −5251−5560 −4139 −4798 −6328 −5454 −5976 −5741 −5026 4302 −5328 −5104 −4798−4844 −5739 −4665 −5484 390 — −149 −500 233 43 −381 399 106 −626 210−466 −720 275 394 45 96 359 117 −369 −294 −249 — −12 −7945 −8987 −894−1115 −701 −1378 −9818 −8655 389(D −2522 −4504 3422 1446 −4683 938 −1750−4661 −2127 −4504 −3910 −909 −2894 −1438 −3092 −2147 −2619 −4102 −4695−3603 391 — −149 −500 233 43 −381 399 106 −626 210 −466 −720 275 394 4596 359 117 −369 −294 −249 — −12 −7945 −8987 −894 −1115 −701 −1378 −9818−8651 390( −3715 −3061 −5054 −5000 2784 −4779 −1574 −1778 −4602 1668−1132 −3738 −4524 −3553 −4110 −4005 −3593 −2304 4571 289 392 — −149 −500233 43 −381 399 106 −626 210 −466 −720 275 394 45 96 359 117 −369 −294−249 — −12 −7945 −8987 −894 −1115 −701 −1378 −9818 −8647 391(H −1137−2529 1169 −405 −2911 −2042 2148 −2611 1514 −2512 −1626 −678 −2128 17222034 −1013 −1053 −2189 −2623 −2031 393 — −149 −500 233 43 −381 399 106−626 210 −466 −720 275 394 45 96 359 117 −369 −294 −249 — −12 −7945−8987 −894 −1115 −701 −1378 −9818 −8644 392(Q −1523 −3117 2166 1365−3403 −2057 −1004 −3194 1438 −3110 −2253 −667 −2351 2526 −1325 −1325−1499 −2728 −3276 −2509 394 — −149 −500 233 43 −381 399 106 −626 210−466 −720 275 394 45 96 359 117 −369 −294 −249 — −12 −7945 −8987 −894−1115 −701 −1378 −9818 −8640 393(Y −4598 −3559 −5006 −5329 2257 −48982594 −3515 −4887 −2848 −2926 −3523 −4759 −3654 −4280 −4143 −4453 −3662−366 4237 395 — −149 −500 233 43 −381 399 106 −626 210 −466 −720 275 39445 96 359 117 −369 −294 −249 — −12 −7945 −8988 −894 −1115 −701 −1378−9818 −8637 394(A 2380 −2381 −1061 1282 −3846 2045 −1941 −3614 −1958−3704 −2890 −1385 −2665 −1636 −2457 −1509 −1729 −2895 −3915 −3319 396 —−149 −500 233 43 −381 399 106 −626 210 −466 −720 275 394 45 96 359 117−369 −294 −249 — −12 −7945 −8988 −894 −1115 −701 −1378 −9818 −8633 395(V−2097 −1741 −4406 −4026 −2222 −4103 −3555 2399 −3840 −1319 −1108 1444−4071 −3681 −3882 −3349 −2094 2762 −3366 −2920 397 — −149 −500 233 43−381 399 106 −626 210 −466 −720 275 394 45 96 359 117 −369 −294 −249 —−12 −7945 −8988 −894 −1115 −701 −1378 −9818 −8629 396(D −928 −2371 1886−165 −2715 −1822 −563 −2464 1387 −2421 −1512 −478 1080 −116 −692 7501043 −2018 −2599 −1913 398 — * * * * * * * * * * * * * * * * * * * *— * * * * * * * −9818 0

TABLE 8 HMMER2.0 [2.3.2] NAME XFP ACC PF03894.6 DESC D-xylulose5-phosphate/D-fructose 6-phosphate phosphoketolase LENG 187 ALPH AminoRF no CS no MAP yes COM hmmbuild -f -F HMM fs.ann SEED.ann COMhmmcalibrate --seed 0 HMM fs.ann NSEQ 6 DATE Sun Apr 29 15:58:33 2007CKSUM 8559 GA 15.5 15.5 TC 18.2 15.7 NC 13.6 14.2 XT −8455 −4 −1000−1000 −8455 −4 −8455 −4 NULT −4 −8455 NULE 595 −1558 85 338 −294 453−1158 197 249 902 −1085 −142 −21 −313 45 531 201 384 −1998 −644 EVD−10.339054 0.664450 A C D E F G H I K HMM m−>m m−>i m−>d i−>m i−>i d−>md−>d b−>m m−>e L M −222 * −2807  1(M) −919 −1308 −2565 −2222 −1930 −1975−1841 −1394 −1946 −1641 3218 — −149 −500 233 43 −381 399 106 −626 210−466 −720 — −14 −7717 −8760 −894 −1115 −701 −1378 −1222 −8539  2(R) 691−1720 −837 −294 −1975 −1756 −501 673 −144 −1751 −937 — −149 −500 233 43−381 399 106 −626 210 −466 −720 — −14 −7717 −8760 −894 −1115 −701 −1378−8762 −8535  3(V) −885 −1621 −999 990 −1982 −1862 −915 −1514 −733 −1796−1048 — −149 −500 233 43 −381 399 106 −626 210 −466 −720 — −14 −7717−8760 −894 −1115 −701 −1378 −8762 −8531  4(L) −2842 −2379 −5209 −4634−994 −4802 −3633 −174 −4364 2574 2538 — −149 −500 233 43 −381 399 106−626 210 −466 −720 — −14 −7717 −8760 −894 −1115 −701 −1378 −8762 −8527 5(G) −1046 −1667 −2864 −3162 −4077 3372 −3114 −3979 −3511 −4193 −3299 —−149 −500 233 43 −381 399 106 −626 210 −466 −720 — −14 −7717 −8760 −894−1115 −701 −1378 −8762 −8524  6(K) 696 −1959 −661 −115 −2242 −1707 −387−1932 1754 −1971 −1104 — −149 −500 233 43 −381 399 106 −626 210 −466−720 — −14 −7717 −8760 −894 −1115 −701 −1378 −8762 −8520  7(Y) −4363−3343 −4802 −5127 2939 −4674 −927 −3251 −4692 −2586 −2669 — −149 −500233 43 −381 399 106 −626 210 −466 −720 — −14 −7717 −8760 −894 −1115 −701−1378 −8762 −8516  8(C) −1627 2687 −3970 −3367 1521 −3283 −2148 −37−3007 2149 118 — −149 −500 233 43 −381 399 106 −626 210 −466 −720 — −14−7718 −8760 −894 −1115 −701 −1378 −8762 −8512  9(R) 737 −2550 1594 −497−3149 −1980 −968 −2870 −526 −2846 −2019 — −149 −500 233 43 −381 399 106−626 210 −466 −720 — −14 −7718 −8760 −894 −1115 −701 −1378 −8762 −8508 10(D) −2399 −4358 3324 2308 −4527 −2166 −1608 −4527 −1994 −4367 −3790 —−149 −500 233 43 −381 399 106 −626 210 −466 −720 — −14 −7718 −8760 −894−1115 −701 −1378 −8762 −8504  11(V) −2284 −1804 −4895 −4504 −1990 −4629−4189 2412 −4382 1011 −761 — −149 −500 233 43 −381 399 106 −626 210 −466−720 — −14 −7718 −8760 −894 −1115 −701 −1378 −8762 −8500  12(M) −2278−1867 −4746 −4224 −1303 −4284 −3343 1656 −3973 1240 3304 — −149 −500 23343 −381 399 106 −626 210 −466 −720 — −14 −7718 −8760 −894 −1115 −701−1378 −8762 −8496  13(K) 693 −2202 −1423 −749 −2553 −2182 −674 −21072480 −2170 −1388 — −149 −500 233 43 −381 399 106 −626 210 −466 −720 —−14 −7718 −8760 −894 −1115 −701 −1378 −8762 −8492  14(N) −1049 −1434−1773 −1500 −1636 −2109 −1397 −1127 −1366 1815 −824 — −149 −500 233 43−381 399 106 −626 210 −466 −720 — −14 −7718 −8760 −894 −1115 −701 −1378−8762 −8488  15(N) −3232 −3514 −2565 −2905 −4358 −3267 −3364 −5192 −3627−5059 −4632 — −149 −500 233 43 −381 399 106 −626 210 −466 −720 — −867−7718 −1171 −894 −1115 −701 −1378 −8762 −8484  16(E) −1220 −2441 99 2757−2966 −1568 −808 −2774 −675 −2772 −2036 — −149 −500 233 43 −381 399 106−626 210 −466 −720 — −22 −6873 −7915 −894 −1115 −2169 −363 −8762 −8480 17(D) −1004 −1749 2891 −305 −2104 −1632 −964 −886 −981 −1762 −1266 —−149 −500 233 43 −381 399 106 −626 210 −466 −720 — −460 −6873 −1933 −894−1115 −216 −2846 −8762 −8476  18(M) 823 −1578 1383 −173 −1837 −1620 −411−1480 −107 −1624 2041 — −149 −500 233 43 −381 399 106 −626 210 −466 −720— −16 −7493 −8536 −894 −1115 −1355 −715 −8762 −8472  19(T) −897 −2121−888 −291 −2541 −1825 −413 −2206 1465 −2164 −1310 — −149 −500 233 43−381 399 106 −626 210 −466 −720 — −16 −7493 −8536 −894 −1115 −404 −2032−8762 −8468  20(N) −867 −2024 −881 −423 −2654 −1782 −693 −2361 −230−2371 −1499 — −149 −500 233 43 −381 399 106 −626 210 −466 −720 — −14−7718 −8760 −894 −1115 −701 −1378 −8762 −8464  21(F) −3465 −2876 −5057−4893 3938 −4762 −2035 −1021 −4547 1305 −409 — −149 −500 233 43 −381 399106 −626 210 −466 −720 — −14 −7718 −8760 −894 −1115 −701 −1378 −8762−8459  22(R) −4070 −3868 −4406 −3890 −4820 −3837 −3026 −5122 −1946 −4739−4314 — −149 −500 233 43 −381 399 106 −626 210 −466 −720 — −14 −7718−8760 −894 −1115 −701 −1378 −8762 −8455  23(I) −2379 −1901 −4955 −4531−1728 −4662 −4059 2900 −4381 1570 −512 — −149 −500 233 43 −381 399 106−626 210 −466 −720 — −14 −7718 −8760 −894 −1115 −701 −1378 −8762 −8451 24(F) −2676 −2354 −4538 −4394 3992 −3956 −1878 −728 −4074 −869 −929 —−149 −500 233 43 −381 399 106 −626 210 −466 −720 — −14 −7718 −8760 −894−1115 −701 −1378 −8762 −8447  25(G) −1031 −1653 −2874 −3165 −4069 3287−3106 −3964 −3500 −4180 −3282 — −149 −500 233 43 −381 399 106 −626 210−466 −720 — −14 −7718 −8760 −894 −1115 −701 −1378 −8762 −8443  26(P)−4077 −3791 −4518 −4858 −5206 −3818 −4460 −5898 −5053 −5602 −5343 — −149−500 233 43 −381 399 106 −626 210 −466 −720 — −14 −7718 −8760 −894 −1115−701 −1378 −8762 −8439  27(D) −3832 −4189 4132 −2236 −5073 −3341 −3194−5633 −3716 −5365 −5035 — −149 −500 233 43 −381 399 106 −626 210 −466−720 — −14 −7718 −8760 −894 −1115 −701 −1378 −8762 −8435  28(E) −3777−4125 −1925 3871 −4984 −3355 −3125 −5379 −3371 −5156 −4796 — −149 −500233 43 −381 399 106 −626 210 −466 −720 — −14 −7718 −8760 −894 −1115 −701−1378 −8762 −8430  29(T) −1009 −1466 −1761 −1492 −1840 −2028 −1429 −1343−1350 766 −1045 — −149 −500 233 43 −381 399 106 −626 210 −466 −720 — −14−7718 −8760 −894 −1115 −701 −1378 −8762 −8426  30(M) 1499 −1643 −9171243 −1962 −1786 −691 −1586 −425 −1763 2853 — −149 −500 233 43 −381 399106 −626 210 −466 −720 — −14 −7718 −8760 −894 −1115 −701 −1378 −8762−8422  31(S) −1644 −2173 −3321 −3615 −4077 −2357 −3411 −4307 −3792 −4459−3725 — −149 −500 233 43 −381 399 106 −626 210 −466 −720 — −14 −7718−8760 −894 −1115 −701 −1378 −8762 −8418  32(N) −3232 −3514 −2565 −2905−4358 −3267 −3364 −5192 −3627 −5059 −4632 — −149 −500 233 43 −381 399106 −626 210 −466 −720 — −14 −7718 −8760 −894 −1115 −701 −1378 −8762−8414  33(R) −2793 −3369 −3662 −2108 −4312 −3237 −1071 −3580 2493 −3189−2545 — −149 −500 233 43 −381 399 106 −626 210 −466 −720 — −14 −7718−8760 −894 −1115 −701 −1378 −8762 −8409  34(L) −3410 −2836 −5464 −50391728 −5176 −3154 −570 −4762 2953 115 — −149 −500 233 43 −381 399 106−626 210 −466 −720 — −15 −7719 −8761 −894 −1115 −701 −1378 −8762 −8406 35(W) −901 −2337 1407 −65 −2541 −1747 2100 −2368 −133 −2334 −1447 —−149 −500 233 43 −381 399 106 −626 210 −466 −720 — −15 −7718 −8760 −894−1115 −701 −1378 −8762 −8401  36(A) 2155 −3109 1523 1273 −3479 1112−1076 −3288 −1004 −3231 −2417 — −149 −500 233 43 −381 399 106 −626 210−466 −720 — −15 −7718 −8760 −894 −1115 −701 −1378 −8762 −8397  37(V)1023 −958 −3146 −2600 −1103 −2513 −1686 63 −2290 −801 2200 — −149 −500233 43 −381 399 106 −626 210 −466 −720 — −15 −7718 −8760 −894 −1115 −701−1378 −8762 −8392  38(F) −3852 −3057 −4741 −4884 3355 −4537 −1011 −2489−4461 957 −1921 — −149 −500 233 43 −381 399 106 −626 210 −466 −720 — −15−7718 −8760 −894 −1115 −701 −1378 −8762 −8388  39(E) −2083 −3395 −7222943 −3878 −2383 −1214 −3575 2285 −3395 −2666 — −149 −500 233 43 −381399 106 −626 210 −466 −720 — −15 −7718 −8760 −894 −1115 −701 −1378 −8762−8384  40(V) −1086 −1419 −2113 −1929 −1724 796 2671 −1274 −1766 −1761−1123 — −149 −500 233 43 −381 399 106 −626 210 −466 −720 — −15 −7718−8760 −894 −1115 −701 −1378 −8762 −8379  41(T) −869 −1487 −3137 −3257−3760 −1746 −2945 −3506 −3200 −3791 −2920 — −149 −500 233 43 −381 399106 −626 210 −466 −720 — −15 −7718 −8760 −894 −1115 −701 −1378 −8762−8375  42(K) −1040 −2442 −581 1137 −2735 −1868 −548 −2490 2386 −2427−1554 — −149 −500 233 43 −381 399 106 −626 210 −466 −720 — −15 −7718−8760 −894 −1115 −701 −1378 −8762 −8371  43(R) −2795 −3370 −3663 −2111−4313 −3239 −1074 −3582 2384 −3191 −2548 — −149 −500 233 43 −381 399 106−626 210 −466 −720 — −291 −7718 −2514 −894 −1115 −701 −1378 −8762 −8366 44(Q) −1085 −1755 −1145 −887 1733 985 −888 −1755 −814 −1851 −1208 —−149 −500 233 43 −381 399 106 −626 210 −466 −720 — −17 −7443 −8485 −894−1115 −1459 −652 −8762 −8362  45(W) −4735 −3754 −4703 −4993 −2377 −3915−3273 −4870 −4782 −4319 −4338 — −149 −500 233 43 −381 399 106 −626 210−466 −720 — −17 −7443 −8486 −894 −1115 −372 −2136 −8762 −8358  46(M)−914 −874 871 −1922 −783 −2384 −1220 1249 −1670 662 3001 — −149 −500 23343 −381 399 106 −626 210 −466 −720 — −15 −7718 −8760 −894 −1115 −701−1378 −8762 −8353  47(M) 641 −2071 −521 1084 −2362 −1649 −321 −2091 82−2076 2071 — −149 −500 233 43 −381 399 106 −626 210 −466 −720 — −15−7718 −8760 −894 −1115 −701 −1378 −8762 −8349  48(Q) −757 −2178 −5291705 −2487 519 −368 −2219 1195 −2182 −1278 — −149 −500 233 43 −381 399106 −626 210 −466 −720 — −15 −7718 −8760 −894 −1115 −701 −1378 −8762−8344  49(Y) −1288 −1144 −3267 −2757 −710 −2784 −1561 2546 −2393 −763−315 — −149 −500 233 43 −381 399 106 −626 210 −466 −720 — −15 −7718−8760 −894 −1115 −701 −1378 −8762 −8340  50(K) −1352 −2460 1542 −473−2590 −2065 −876 −2234 1932 1737 −1566 — −149 −500 233 43 −381 399 106−626 210 −466 −720 — −15 −7718 −8760 −894 −1115 −701 −1378 −8762 −8335 51(P) −1299 −2774 −236 1949 −3178 −1870 −886 −2961 −678 −2912 −2058 —−149 −500 233 43 −381 399 106 −626 210 −466 −720 — −291 −7718 −2514 −894−1115 −701 −1378 −8762 −8331  52(P) 1084 −2190 −341 2185 −2933 −1688−929 −2655 −732 −2706 −1884 — −149 −500 233 43 −381 399 106 −626 210−466 −720 — −17 −7443 −8486 −894 −1115 −1459 −652 −8762 −8326  53(N)−1418 −2809 2479 −106 −2949 −1799 −926 −2766 −883 578 −2068 — −149 −500233 43 −381 399 106 −626 210 −466 −720 — −283 −7443 −2563 −894 −1115−1459 −652 −8762 −8322  54(D) −888 −2124 2400 66 −2357 −1565 −509 −1956−285 −2113 −1336 — −149 −500 233 43 −381 399 106 −626 210 −466 −720 —−19 −7180 −8222 −894 −1115 −1865 −463 −8762 −8317  55(D) −1805 −36802903 2554 −3868 −1689 −1066 −3813 −1341 −3684 −3041 — −149 −500 233 43−381 399 106 −626 210 −466 −720 — −1334 −7180 −753 −894 −1115 −1865 −463−8762 −8313  56(G) −515 −887 −1038 −1187 −2183 3187 −1282 −2175 −1398−2342 −1770 — −149 −500 233 43 −381 399 106 −626 210 −466 −720 — −41−5887 −6930 −894 −1115 −2652 −250 −8762 −8308  57(G) −515 −887 −1038−1187 −2183 3187 −1282 −2175 −1398 −2342 −1770 — −149 −500 233 43 −381399 106 −626 210 −466 −720 — −41 −5887 −6930 −894 −1115 −151 −3329 −8762−8304  58(E) −1346 −1562 −1816 2436 2337 −2525 −1279 −603 −1533 −1038−631 — −149 −500 233 43 −381 399 106 −626 210 −466 −720 — −15 −7718−8760 −894 −1115 −701 −1378 −8762 −8299  59(H) −933 −961 −2242 −1707−764 −2320 2094 1132 −1393 1839 −65 — −149 −500 233 43 −381 399 106 −626210 −466 −720 — −15 −7718 −8760 −894 −1115 −701 −1378 −8762 −8295  60(M)−1293 −1342 −2996 −2500 −1038 −2617 −1796 −510 −2162 890 3410 — −149−500 233 43 −381 399 106 −626 210 −466 −720 — −15 −7718 −8760 −894 −1115−701 −1378 −8762 −8290  61(P) 2028 −1663 −1726 −1624 −3398 998 −1915−3145 −1828 −3283 −2409 — −149 −500 233 43 −381 399 106 −626 210 −466−720 — −15 −7718 −8760 −894 −1115 −701 −1378 −8762 −8285  62(D) −752−2203 1771 1070 −2520 −1688 −359 −2261 1383 −2210 −1298 — −149 −500 23343 −381 399 106 −626 210 −466 −720 — −231 −7718 −2838 −894 −1115 −701−1378 −8762 −8281  63(R) −796 −2105 −516 1238 −2496 1498 −421 −2206 49−2188 −1314 — −149 −500 233 43 −381 399 106 −626 210 −466 −720 — −17−7504 −8546 −894 −1115 −412 −2011 −8762 −8276  64(G) −2419 −2885 −3067−2886 −4406 3143 −2559 −4353 −1679 −4234 −3572 — −149 −500 233 43 −381399 106 −626 210 −466 −720 — −15 −7718 −8760 −894 −1115 −701 −1378 −8762−8271  65(R) −1920 −2516 −2433 −1527 −2802 −2746 −961 1879 176 −2261−1647 — −149 −500 233 43 −381 399 106 −626 210 −466 −720 — −15 −7718−8760 −894 −1115 −701 −1378 −8762 −8267  66(V) −2252 −1773 −4891 −4567−2335 −4633 −4538 1812 −4482 −1132 −1073 — −149 −500 233 43 −381 399 106−626 210 −466 −720 — −15 −7718 −8760 −894 −1115 −701 −1378 −8762 −8262 67(M) −849 −923 1670 −1529 −893 −2248 −1067 −233 −1327 600 2147 — −149−500 233 43 −381 399 106 −626 210 −466 −720 — −15 −7718 −8760 −894 −1115−701 −1378 −8762 −8257  68(E) −1776 −3015 −373 3097 −3872 −2071 −1546−3755 −1570 −3731 −2992 — −149 −500 233 43 −381 399 106 −626 210 −466−720 — −15 −7718 −8760 −894 −1115 −701 −1378 −8762 −8253  69(M) −1335−1165 −3272 −2688 −1002 −2941 −1834 1451 −2360 −376 3121 — −149 −500 23343 −381 399 106 −626 210 −466 −720 — −15 −7718 −8760 −894 −1115 −701−1378 −8762 −8248  70(L) −3777 −3243 −5089 −5032 −1735 −4514 −4040 −1299−4754 3261 −696 — −149 −500 233 43 −381 399 106 −626 210 −466 −720 — −15−7718 −8760 −894 −1115 −701 −1378 −8762 −8243  71(S) −1644 −2173 −3321−3615 −4077 −2357 −3411 −4307 −3792 −4459 −3725 — −149 −500 233 43 −381399 106 −626 210 −466 −720 — −15 −7718 −8760 −894 −1115 −701 −1378 −8762−8238  72(E) −3777 −4125 −1925 3871 −4984 −3355 −3125 −5379 −3371 −5156−4796 — −149 −500 233 43 −381 399 106 −626 210 −466 −720 — −15 −7718−8760 −894 −1115 −701 −1378 −8762 −8234  73(H) −4406 −3961 −3921 −4171−3231 −3926 5401 −5468 −3992 −5013 −4849 — −149 −500 233 43 −381 399 106−626 210 −466 −720 — −15 −7718 −8760 −894 −1115 −701 −1378 −8762 −8229 74(Q) −1172 −1561 −1803 −1343 −1477 −2292 −1190 −991 −908 1463 −565 —−149 −500 233 43 −381 399 106 −626 210 −466 −720 — −15 −7718 −8760 −894−1115 −701 −1378 −8762 −8224  75(C) 943 4854 −3669 −3391 −1886 −2164−2449 −922 −3000 676 −1025 — −149 −500 233 43 −381 399 106 −626 210 −466−720 — −15 −7718 −8761 −894 −1115 −701 −1378 −8762 −8219  76(E) −2096−3637 −282 2979 −3947 −2215 −1377 −3824 −1173 −3688 −2987 — −149 −500233 43 −381 399 106 −626 210 −466 −720 — −15 −7718 −8761 −894 −1115 −701−1378 −8762 −8214  77(G) −3681 −3593 −4389 −4747 −5281 3812 −4419 −5908−5071 −5671 −5288 — −149 −500 233 43 −381 399 106 −626 210 −466 −720 —−15 −7718 −8761 −894 −1115 −701 −1378 −8762 −8209  78(W) −4254 −3318−4804 −5081 3098 −4588 −1050 −3111 −4645 −2453 −2534 — −149 −500 233 43−381 399 106 −626 210 −466 −720 — −15 −7718 −8761 −894 −1115 −701 −1378−8762 −8205  79(L) −3375 −2814 −5645 −5079 −928 −5372 −4042 −409 −47772894 2856 — −149 −500 233 43 −381 399 106 −626 210 −466 −720 — −15 −7718−8761 −894 −1115 −701 −1378 −8762 −8200  80(E) −2150 −3708 −263 3290−4011 −2224 −1421 −3906 −1260 −3766 −3081 — −149 −500 233 43 −381 399106 −626 210 −466 −720 — −15 −7718 −8761 −894 −1115 −701 −1378 −8762−8195  81(G) 2022 −1618 −3291 −3557 −4069 3053 −3239 −3867 −3682 −4133−3245 — −149 −500 233 43 −381 399 106 −626 210 −466 −720 — −15 −7718−8761 −894 −1115 −701 −1378 −8762 −8190  82(Y) −4444 −3646 −4593 −4892−509 −4268 −1873 −3993 −4663 −3407 −3460 — −149 −500 233 43 −381 399 106−626 210 −466 −720 — −15 −7719 −8761 −894 −1115 −701 −1378 −8762 −8185 83(L) −1931 −1973 −3870 −3595 −1374 −3144 −2842 −646 −3171 2519 −338 —−149 −500 233 43 −381 399 106 −626 210 −466 −720 — −15 −7719 −8761 −894−1115 −701 −1378 −8762 −8180  84(L) −3777 −3243 −5089 −5032 −1735 −4514−4040 −1299 −4754 3261 −696 — −149 −500 233 43 −381 399 106 −626 210−466 −720 — −15 −7719 −8761 −894 −1115 −701 −1378 −8762 −8175  85(T)−2081 −2497 −3792 −4048 −4206 −2712 −3671 −3972 −3974 −4274 −3765 — −149−500 233 43 −381 399 106 −626 210 −466 −720 — −15 −7719 −8761 −894 −1115−701 −1378 −8762 −8170  86(G) −3681 −3593 −4389 −4747 −5281 3812 −4419−5908 −5071 −5671 −5288 — −149 −500 233 43 −381 399 106 −626 210 −466−720 — −15 −7719 −8761 −894 −1115 −701 −1378 −8762 −8165  87(R) −4070−3868 −4406 −3890 −4820 −3837 −3026 −5122 −1946 −4739 −4314 — −149 −500233 43 −381 399 106 −626 210 −466 −720 — −15 −7719 −8761 −894 −1115 −701−1378 −8762 −8160  88(H) −1602 −2202 −2033 −2051 −2524 −2310 4500 −3130−1754 −3221 −2593 — −149 −500 233 43 −381 399 106 −626 210 −466 −720 —−15 −7719 −8761 −894 −1115 −701 −1378 −8762 −8155  89(G) 1424 −1648−3257 −3538 −4097 3299 −3253 −3902 −3697 −4166 −3283 — −149 −500 233 43−381 399 106 −626 210 −466 −720 — −15 −7719 −8761 −894 −1115 −701 −1378−8762 −8150  90(F) 653 −1307 −3869 −3274 2383 −3222 −2101 2307 −2923 97954 — −149 −500 233 43 −381 399 106 −626 210 −466 −720 — −15 −7719 −8761−894 −1115 −701 −1378 −8762 −8145  91(F) −4268 −3318 −4807 −5092 4134−4606 −1026 −3118 −4656 −2457 −2538 — −149 −500 233 43 −381 399 106 −626210 −466 −720 — −15 −7719 −8761 −894 −1115 −701 −1378 −8762 −8140  92(A)2436 −1450 −3080 −3062 −3722 −1707 −2801 −3478 −3005 −3713 −2813 — −149−500 233 43 −381 399 106 −626 210 −466 −720 — −15 −7719 −8761 −894 −1115−701 −1378 −8762 −8134  93(S) −797 2971 −3664 −3672 −3546 −1712 −2998−3220 −3388 −3539 −2685 — −149 −500 233 43 −381 399 106 −626 210 −466−720 — −15 −7719 −8761 −894 −1115 −701 −1378 −8762 −8129  94(Y) −4444−3646 −4593 −4892 −509 −4268 −1873 −3993 −4663 −3407 −3460 — −149 −500233 43 −381 399 106 −626 210 −466 −720 — −15 −7719 −8761 −894 −1115 −701−1378 −8762 −8124  95(E) −3777 −4125 −1925 3871 −4984 −3355 −3125 −5379−3371 −5156 −4796 — −149 −500 233 43 −381 399 106 −626 210 −466 −720 —−15 −7719 −8761 −894 −1115 −701 −1378 −8762 −8119  96(A) 2588 −1457−3368 −3530 −3881 −1722 −3095 −3647 −3472 −3926 −3021 — −149 −500 233 43−381 399 106 −626 210 −466 −720 — −15 −7719 −8761 −894 −1115 −701 −1378−8762 −8114  97(F) −4350 −3618 −4843 −5137 4483 −4245 −2206 −3493 −4990−2887 −3007 — −149 −500 233 43 −381 399 106 −626 210 −466 −720 — −15−7719 −8761 −894 −1115 −701 −1378 −8762 −8109  98(M) 706 −1201 −3821−3231 −1007 −3165 −2103 1510 −2884 1469 2600 — −149 −500 233 43 −381 399106 −626 210 −466 −720 — −15 −7719 −8761 −894 −1115 −701 −1378 −8762−8103  99(H) −1732 −2580 −1961 −1265 −3039 −2507 3869 −2740 117 −2656−1919 — −149 −500 233 43 −381 399 106 −626 210 −466 −720 — −16 −7719−8761 −894 −1115 −701 −1378 −8762 −8098 100(I) −2262 −1772 −4916 −4590−2360 −4692 −4608 2948 −4520 −1146 −1086 — −149 −500 233 43 −381 399 106−626 210 −466 −720 — −16 −7719 −8761 −894 −1115 −701 −1378 −8762 −8093101(V

−2259 −1770 −4911 −4585 −2361 −4682 −4599 2472 −4513 −1151 −1088 — −149−500 233 43 −381 399 106 −626 210 −466 −720 — −16 −7719 −8761 −894 −1115−701 −1378 −8762 −8087 102(D

−1281 −2033 3087 −908 −2698 −2028 −1475 −1596 −1454 −2381 −1758 — −149−500 233 43 −381 399 106 −626 210 −466 −720 — −16 −7719 −8761 −894 −1115−701 −1378 −8762 −8082 103(S) −1644 −2173 −3321 −3615 −4077 −2357 −3411−4307 −3792 −4459 −3725 — −149 −500 233 43 −381 399 106 −626 210 −466−720 — −16 −7719 −8761 −894 −1115 −701 −1378 −8762 −8077 104(M

−3457 −3250 −4578 −4682 −2595 −3839 −3833 −2264 −4294 −1708 5248 — −149−500 233 43 −381 399 106 −626 210 −466 −720 — −16 −7719 −8761 −894 −1115−701 −1378 −8762 −8071 105(L) −2433 −2031 −4839 −4270 1637 −4331 −32171476 −3985 2288 96 — −149 −500 233 43 −381 399 106 −626 210 −466 −720 —−16 −7719 −8761 −894 −1115 −701 −1378 −8762 −8066 106(N

−952 −1482 −1959 −1737 −2360 −1930 −1748 −1480 −1701 −2148 −1486 — −149−500 233 43 −381 399 106 −626 210 −466 −720 — −16 −7719 −8761 −894 −1115−701 −1378 −8762 −8061 107(Q

−3758 −3792 −3072 −3245 −4342 −3586 −3274 −5053 −2880 −4719 −4410 — −149−500 233 43 −381 399 106 −626 210 −466 −720 — −16 −7719 −8761 −894 −1115−701 −1378 −8762 −8055 108(H

−3941 −3303 −3939 −4079 336 −4266 4844 −3317 −3580 −2730 −2734 — −149−500 233 43 −381 399 106 −626 210 −466 −720 — −16 −7719 −8761 −894 −1115−701 −1378 −8762 −8050 109(A

2381 −1319 −2661 −2353 1521 924 −2061 −2159 −2216 −2443 −1684 — −149−500 233 43 −381 399 106 −626 210 −466 −720 — −16 −7719 −8761 −894 −1115−701 −1378 −8762 −8044 110(K

−3709 −3782 −3592 −3179 −4734 −3639 −2561 −4748 3938 −4426 −3926 — −149−500 233 43 −381 399 106 −626 210 −466 −720 — −16 −7719 −8761 −894 −1115−701 −1378 −8762 −8039 111(W

−4239 −3322 −4800 −5070 2397 −4565 −1086 −3101 −4634 −2445 −2527 — −149−500 233 43 −381 399 106 −626 210 −466 −720 — −16 −7719 −8761 −894 −1115−701 −1378 −8762 −8033 112(L) −3174 −2633 −5520 −4994 −1029 −5242 −40531453 −4737 2932 174 — −149 −500 233 43 −381 399 106 −626 210 −466 −720 —−16 −7719 −8761 −894 −1115 −701 −1378 −8762 −8028 113(K

−1073 −2547 1983 1205 −2885 −1851 −580 −2624 2040 −2541 −1656 — −149−500 233 43 −381 399 106 −626 210 −466 −720 — −16 −7719 −8761 −894 −1115−701 −1378 −8762 −8022 114(M

1488 −784 −2685 −2089 −758 −2378 −1239 1284 −1794 −540 2454 — −149 −500233 43 −381 399 106 −626 210 −466 −720 — −16 −7719 −8761 −894 −1115 −701−1378 −8762 −8017 115(C

1116 3924 −3654 −3615 −3360 1383 −2916 −3025 −3341 −3335 −2502 — −149−500 233 43 −381 399 106 −626 210 −466 −720 — −1842 −7719 −489 −894−1115 −701 −1378 −8762 −8011 116(V

−588 −579 −2160 −1946 −759 −1834 −1555 1143 −1670 −9 123 — −149 −500 23343 −381 399 106 −626 210 −466 −720 — −42 −5919 −6961 −894 −1115 −152−3320 −8762 −8006 117(R

740 −1533 −1479 −915 −1874 −1953 −873 −1460 −464 601 −933 — −149 −500233 43 −381 399 106 −626 210 −466 −720 — −16 −7719 −8761 −894 −1115 −701−1378 −8762 −8000 118(E) −1519 −3167 1458 2619 −3424 −1929 2323 −3240−838 −3155 −2323 — −149 −500 233 43 −381 399 106 −626 210 −466 −720 —−16 −7719 −8761 −894 −1115 −701 −1378 −8762 −7994 119(I) −1108 −1022−2831 −2246 −840 −2607 −1460 2037 −1908 1407 36 — −149 −500 233 43 −381399 106 −626 210 −466 −720 — −16 −7719 −8761 −894 −1115 −701 −1378 −8762−7989 120(P) −1226 −2486 −581 −427 −3101 1037 −903 −2834 1189 −2796−1949 — −149 −500 233 43 −381 399 106 −626 210 −466 −720 — −16 −7719−8761 −894 −1115 −701 −1378 −8762 −7983 121(W

−5218 −4132 −5085 −5404 −2925 −4252 −3753 −5470 −5268 −4877 −4907 — −149−500 233 43 −381 399 106 −626 210 −466 −720 — −16 −7719 −8761 −894 −1115−701 −1378 −8762 −7977 122(R

−2786 −3324 −3159 −2158 −3444 −3203 2835 −3646 19 −3307 −2690 — −149−500 233 43 −381 399 106 −626 210 −466 −720 — −16 −7719 −8761 −894 −1115−701 −1378 −8762 −7972 123(H

661 −2311 −894 −302 −2686 811 2065 −2371 1951 −2300 −1425 — −149 −500233 43 −381 399 106 −626 210 −466 −720 — −16 −7719 −8761 −894 −1115 −701−1378 −8762 −7966 124(D

−1783 −3362 2774 −330 −3711 −2050 −1197 −3534 1468 −3445 −2669 — −149−500 233 43 −381 399 106 −626 210 −466 −720 — −16 −7719 −8761 −894 −1115−701 −1378 −8762 −7960 125(I) −2784 −2321 −4408 −4214 2256 −4011 −11933098 −3823 −1290 −1179 — −149 −500 233 43 −381 399 106 −626 210 −466−720 — −16 −7719 −8761 −894 −1115 −701 −1378 −8762 −7954 126(S) 1918−1460 −2882 −2748 −3664 1367 −2596 −3426 −2688 −3630 −2719 — −149 −500233 43 −381 399 106 −626 210 −466 −720 — −16 −7719 −8762 −894 −1115 −701−1378 −8762 −7948 127(S) −1644 −2173 −3321 −3615 −4077 −2357 −3411 −4307−3792 −4459 −3725 — −149 −500 233 43 −381 399 106 −626 210 −466 −720 —−16 −7719 −8762 −894 −1115 −701 −1378 −8762 −7943 128(L) −2843 −2399−5187 −4720 −1139 −4765 −3832 −83 −4437 2876 38 — −149 −500 233 43 −381399 106 −626 210 −466 −720 — −16 −7719 −8762 −894 −1115 −701 −1378 −8762−7937 129(N

−3232 −3514 −2565 −2905 −4358 −3267 −3364 −5192 −3627 −5059 −4632 — −149−500 233 43 −381 399 106 −626 210 −466 −720 — −16 −7719 −8762 −894 −1115−701 −1378 −8762 −7931 130(Y

−1616 −1344 −3951 −3366 −912 −3313 −2164 1486 −3018 1578 −20 — −149 −500233 43 −381 399 106 −626 210 −466 −720 — −16 −7719 −8762 −894 −1115 −701−1378 −8762 −7925 131(I) −2438 −1963 −4986 −4538 −1573 −4670 −3957 2309−4367 2112 −365 — −149 −500 233 43 −381 399 106 −626 210 −466 −720 — −16−7720 −8762 −894 −1115 −701 −1378 −8762 −7919 132(M

694 −667 −2636 −2033 −642 −2235 −1106 −145 −1725 645 2178 — −149 −500233 43 −381 399 106 −626 210 −466 −720 — −16 −7720 −8762 −894 −1115 −701−1378 −8762 −7913 133(T) −866 −1487 −3132 −3246 −3768 −1744 −2940 −3519−3190 −3799 −2925 — −149 −500 233 43 −381 399 106 −626 210 −466 −720 —−16 −7720 −8762 −894 −1115 −701 −1378 −8762 −7907 134(S) −1644 −2173−3321 −3615 −4077 −2357 −3411 −4307 −3792 −4459 −3725 — −149 −500 233 43−381 399 106 −626 210 −466 −720 — −16 −7720 −8762 −894 −1115 −701 −1378−8762 −7901 135(H

−1254 −2216 −843 −755 −2687 −1970 3314 −2636 −839 −2710 −1932 — −149−500 233 43 −381 399 106 −626 210 −466 −720 — −16 −7720 −8762 −894 −1115−701 −1378 −8762 −7895 136(W

−2217 −1998 −4211 −3930 −1050 −3517 −2291 −446 −3456 −1314 −1150 — −149−500 233 43 −381 399 106 −626 210 −466 −720 — −16 −7720 −8762 −894 −1115−701 −1378 −8762 −7889 137(W

1105 −2160 −3956 −3730 1959 −3434 −1130 −1795 −3348 −1692 −1411 — −149−500 233 43 −381 399 106 −626 210 −466 −720 — −16 −7720 −8762 −894 −1115−701 −1378 −8762 −7883 138(R

−2269 −3123 −2497 −1540 −3728 −2880 2414 −3259 347 −2971 −2265 — −149−500 233 43 −381 399 106 −626 210 −466 −720 — −16 −7720 −8762 −894 −1115−701 −1378 −8762 −7877 139(Q

−3758 −3792 −3072 −3245 −4342 −3586 −3274 −5053 −2880 −4719 −4410 — −149−500 233 43 −381 399 106 −626 210 −466 −720 — −16 −7720 −8762 −894 −1115−701 −1378 −8762 −7870 140(D

−2399 −4357 3309 2333 −4526 −2166 −1607 −4526 −1993 −4365 −3789 — −149−500 233 43 −381 399 106 −626 210 −466 −720 — −16 −7720 −8762 −894 −1115−701 −1378 −8762 −7864 141(H

−4406 −3961 −3921 −4171 −3231 −3926 5401 −5468 −3992 −5013 −4849 — −149−500 233 43 −381 399 106 −626 210 −466 −720 — −16 −7720 −8762 −894 −1115−701 −1378 −8762 −7858 142(N

−3232 −3514 −2565 −2905 −4358 −3267 −3364 −5192 −3627 −5059 −4632 — −149−500 233 43 −381 399 106 −626 210 −466 −720 — −16 −7720 −8762 −894 −1115−701 −1378 −8762 −7852 143(G

−3681 −3593 −4389 −4747 −5281 3812 −4419 −5908 −5071 −5671 −5288 — −149−500 233 43 −381 399 106 −626 210 −466 −720 — −17 −7720 −8762 −894 −1115−701 −1378 −8762 −7845 144(F) −4352 −3337 −4799 −5121 3888 −4670 −928−3235 −4686 −2571 −2654 — −149 −500 233 43 −381 399 106 −626 210 −466−720 — −17 −7720 −8762 −894 −1115 −701 −1378 −8762 −7839 145(T) −866−1487 −3132 −3246 −3768 −1744 −2940 −3519 −3190 −3799 −2925 — −149 −500233 43 −381 399 106 −626 210 −466 −720 — −17 −7720 −8762 −894 −1115 −701−1378 −8762 −7833 146(H

−4406 −3961 −3921 −4171 −3231 −3926 5401 −5468 −3992 −5013 −4849 — −149−500 233 43 −381 399 106 −626 210 −466 −720 — −17 −7720 −8762 −894 −1115−701 −1378 −8762 −7827 147(Q

−3758 −3792 −3072 −3245 −4342 −3586 −3274 −5053 −2880 −4719 −4410 — −149−500 233 43 −381 399 106 −626 210 −466 −720 — −17 −7720 −8762 −894 −1115−701 −1378 −8762 −7820 148(D

−2001 −3292 3601 −626 −4238 −2111 −1759 −4246 −2092 −4199 −3539 — −149−500 233 43 −381 399 106 −626 210 −466 −720 — −17 −7720 −8762 −894 −1115−701 −1378 −8762 −7814 149(P) −4077 −3791 −4518 −4858 −5206 −3818 −4460−5898 −5053 −5602 −5343 — −149 −500 233 43 −381 399 106 −626 210 −466−720 — −17 −7720 −8762 −894 −1115 −701 −1378 −8762 −7807 150(G

−2415 −2868 −3074 −2972 −4434 3359 −2704 −4428 −1915 −4330 −3670 — −149−500 233 43 −381 399 106 −626 210 −466 −720 — −17 −7720 −8762 −894 −1115−701 −1378 −8762 −7801 151(F) −2339 −1986 −4665 −4064 3176 −4095 −2859−229 −3739 1224 2452 — −149 −500 233 43 −381 399 106 −626 210 −466 −720— −17 −7720 −8762 −894 −1115 −701 −1378 −8762 −7794 152(I) −2056 −1731−4386 −3851 −1203 −3873 −2916 2392 −3540 2065 −105 — −149 −500 233 43−381 399 106 −626 210 −466 −720 — −17 −7720 −8762 −894 −1115 −701 −1378−8762 −7788 153(D

−1118 −2211 2195 −621 −3243 803 −1223 −3009 −1065 −3036 −2177 — −149−500 233 43 −381 399 106 −626 210 −466 −720 — −17 −7720 −8762 −894 −1115−701 −1378 −8762 −7781 154(H

−1003 −1199 −2356 −1954 −1388 −2206 3132 −636 −1619 −1264 −667 — −149−500 233 43 −381 399 106 −626 210 −466 −720 — −17 −7720 −8762 −894 −1115−701 −1378 −8762 −7775 155(M

695 −1534 −4131 −3535 −944 −3528 −2430 2154 −3199 1674 2687 — −149 −500233 43 −381 399 106 −626 210 −466 −720 — −17 −7720 −8762 −894 −1115 −701−1378 −8762 −7768 156(L) 682 −1592 −4101 −3606 −1242 −3407 −2684 95−3291 2495 −186 — −149 −500 233 43 −381 399 106 −626 210 −466 −720 — −17−7720 −8762 −894 −1115 −701 −1378 −8762 −7762 157(N

−1782 −3518 1546 1312 −3758 −1994 −1175 −3610 −1194 −3512 −2730 — −149−500 233 43 −381 399 106 −626 210 −466 −720 — −17 −7720 −8762 −894 −1115−701 −1378 −8762 −7755 158(K

−2459 −2938 −2880 −2055 −2893 −3094 −1378 −2442 3407 840 −1882 — −149−500 233 43 −381 399 106 −626 210 −466 −720 — −17 −7720 −8762 −894 −1115−701 −1378 −8762 −7748 159(K

−1148 −2117 −1407 −950 −3066 −1999 −1021 −2720 2980 −2713 −1884 — −149−500 233 43 −381 399 106 −626 210 −466 −720 — −17 −7720 −8762 −894 −1115−701 −1378 −8762 −7741 160(P) 1034 −1295 −2486 −2150 1616 −1809 −1863−1877 −2017 −2165 −1435 — −149 −500 233 43 −381 399 106 −626 210 −466−720 — −17 −7720 −8762 −894 −1115 −701 −1378 −8762 −7735 161(D

−2104 −3998 2881 1352 −4180 1216 −1393 −4095 −1610 −3965 −3275 — −149−500 233 43 −381 399 106 −626 210 −466 −720 — −1843 −7720 −490 −894−1115 −701 −1378 −8762 −7728 162(N

−498 −1221 110 −15 −1620 −964 −477 −1773 −335 −1934 −1330 — −149 −500233 43 −381 399 106 −626 210 −466 −720 — −43 −5920 −6962 −894 −1115−2643 −252 −8762 −7721 163(D

−961 −1901 3312 369 −2315 −1032 −511 −2292 −663 −2377 −1817 — −149 −500233 43 −381 399 106 −626 210 −466 −720 — −43 −5920 −6962 −894 −1115−2643 −252 −8762 −7714 164(H

−997 −1393 −635 −583 −386 −1411 4407 −1664 −259 −1594 −1144 — −149 −500233 43 −381 399 106 −626 210 −466 −720 — −43 −5920 −6962 −894 −1115 −152−3320 −8762 −7707 165(V

−2121 −1684 −4679 −4254 1449 −4310 −3633 2372 −4076 −839 −756 — −149−500 233 43 −381 399 106 −626 210 −466 −720 — −17 −7720 −8763 −894 −1115−701 −1378 −8762 −7700 166(V

−1172 −1063 −3285 −2755 −1280 −2703 −1906 1464 −2465 −907 −407 — −149−500 233 43 −381 399 106 −626 210 −466 −720 — −17 −7721 −8763 −894 −1115−701 −1378 −8762 −7693 167(R

−2428 −3127 −2310 −1828 −3921 −2880 −1372 −3657 −155 −3392 −2732 — −149−500 233 43 −381 399 106 −626 210 −466 −720 — −17 −7721 −8763 −894 −1115−701 −1378 −8762 −7687 168(I) 673 −1102 −3159 −2611 −1247 −2870 −18662195 −2325 −820 −354 — −149 −500 233 43 −381 399 106 −626 210 −466 −720— −17 −7721 −8763 −894 −1115 −701 −1378 −8762 −7679 169(Y

−4444 −3646 −4593 −4892 −509 −4268 −1873 −3993 −4663 −3407 −3460 — −149−500 233 43 −381 399 106 −626 210 −466 −720 — −17 −7721 −8763 −894 −1115−701 −1378 −8762 −7672 170(F) −3400 −2827 −5361 −4990 2846 −5067 −2816−651 −4697 2592 25 — −149 −500 233 43 −381 399 106 −626 210 −466 −720 —−17 −7721 −8763 −894 −1115 −701 −1378 −8762 −7665 171(P) 1191 −1755−3163 −3402 −3998 −1985 −3182 −3756 −3492 −4031 −3233 — −149 −500 233 43−381 399 106 −626 210 −466 −720 — −17 −7721 −8763 −894 −1115 −701 −1378−8762 −7658 172(P) 1902 −1437 −3147 −3131 −3577 −1724 −2798 −3245 −3019−3540 −2684 — −149 −500 233 43 −381 399 106 −626 210 −466 −720 — −17−7721 −8763 −894 −1115 −701 −1378 −8762 −7651 173(D

−3832 −4189 4132 −2236 −5073 −3341 −3194 −5633 −3716 −5365 −5035 — −149−500 233 43 −381 399 106 −626 210 −466 −720 — −17 −7721 −8763 −894 −1115−701 −1378 −8762 −7644 174(A

2913 −1375 −3389 −3354 −3146 1014 −2798 −2432 −3176 −3025 −2284 — −149−500 233 43 −381 399 106 −626 210 −466 −720 — −18 −7722 −8764 −894 −1115−701 −1378 −8762 −7638 175(N

−3232 −3514 −2565 −2905 −4358 −3267 −3364 −5192 −3627 −5059 −4632 — −149−500 233 43 −381 399 106 −626 210 −466 −720 — −18 −7721 −8763 −894 −1115−701 −1378 −8762 −7629 176(C

−775 3036 −2850 −2408 −1588 −1919 −1731 −1110 −2133 −1469 2376 — −149−500 233 43 −381 399 106 −626 210 −466 −720 — −18 −7721 −8763 −894 −1115−701 −1378 −8762 −7622 177(L) −3406 −2832 −5440 −5026 2063 −5151 −3069−587 −4746 2880 97 — −149 −500 233 43 −381 399 106 −626 210 −466 −720 —−18 −7721 −8763 −894 −1115 −701 −1378 −8762 −7615 178(L) −3777 −3243−5089 −5032 −1735 −4514 −4040 −1299 −4754 3261 −696 — −149 −500 233 43−381 399 106 −626 210 −466 −720 — −18 −7721 −8763 −894 −1115 −701 −1378−8762 −7607 179(C

2942 2982 −3827 −3914 −3641 −1706 −3124 −3330 −3613 −3649 −2779 — −149−500 233 43 −381 399 106 −626 210 −466 −720 — −18 −7721 −8763 −894 −1115−701 −1378 −8762 −7600 180(V

−2004 −1608 −4544 −4142 −2135 −4125 −3700 1840 −3967 −1140 −967 — −149−500 233 43 −381 399 106 −626 210 −466 −720 — −18 −7721 −8763 −894 −1115−701 −1378 −8762 −7592 181(F) 1588 −850 −2996 −2447 2261 −2299 −1475−182 −2129 −756 −166 — −149 −500 233 43 −381 399 106 −626 210 −466 −720— −18 −7721 −8763 −894 −1115 −701 −1378 −8762 −7585 182(D

1088 −3814 3226 1427 −4086 −2058 −1384 −3970 −1570 −3872 −3169 — −149−500 233 43 −381 399 106 −626 210 −466 −720 — −18 −7721 −8763 −894 −1115−701 −1378 −8762 −7577 183(H

−2540 −3259 −3155 −1838 −4078 −3083 3373 −3420 2334 −3069 −2392 — −149−500 233 43 −381 399 106 −626 210 −466 −720 — −18 −7721 −8763 −894 −1115−701 −1378 −8762 −7570 184(C

998 4910 −3920 −3803 −2550 −2066 −2898 −917 −3459 −2125 −1635 — −149−500 233 43 −381 399 106 −626 210 −466 −720 — −18 −7721 −8763 −894 −1115−701 −1378 −8762 −7562 185(M

−3195 −2670 −5480 −4897 2597 −5129 −3599 −426 −4630 2310 2844 — −149−500 233 43 −381 399 106 −626 210 −466 −720 — −18 −7721 −8763 −894 −1115−701 −1378 −8762 −7555 186(Q

−1978 −3010 −1873 −1184 −3573 −2640 2315 −3132 2388 −2890 −2142 — −149−500 233 43 −381 399 106 −626 210 −466 −720 — −18 −7721 −8763 −894 −1115−701 −1378 −8762 −7547 187(S) −1150 −2122 1356 −858 −3376 −1832 −1484−3135 −1404 −3212 −2374 — * * * * * * * * * * * — * * * * * * * −8762 0HMM N P Q R S T V W Y  1(M) −1876 1316 −1826 −2064 −1219 2730 −1183−2403 −2047 1 — 275 394 45 96 359 117 −369 −294 −249 —  2(R) 1196 −1878−121 1881 951 −681 −1325 −2078 −1516 2 — 275 394 45 96 359 117 −369 −294−249 —  3(V) −873 1044 −622 −1147 858 −916 2279 −2227 −1717 3 — 275 39445 96 359 117 −369 −294 −249 —  4(L) −4478 −4252 −3491 −4019 −4045 −27351455 −2614 −2661 4 — 275 394 45 96 359 117 −369 −294 −249 —  5(G) −2337−2643 −3089 −3461 1104 −1501 −2797 −4216 −4066 5 — 275 394 45 96 359 117−369 −294 −249 —  6(K) −400 −1809 1727 −429 726 −657 544 −2214 −1595 6 —275 394 45 96 359 117 −369 −294 −249 —  7(Y) −3329 −4545 −3458 −4081−3935 −4227 −3413 −177 4223 7 — 275 394 45 96 359 117 −369 −294 −249 — 8(C) −2930 −3201 −2520 −2790 −2405 −1562 1206 −1785 −1498 8 — 275 39445 96 359 117 −369 −294 −249 —  9(R) −774 −2281 −570 3052 −1221 −1340−2417 −3004 −2383 9 — 275 394 45 96 359 117 −369 −294 −249 —  10(D) −765−2746 −1301 −2956 −2018 −2496 −3976 −4515 −3456 10 — 275 394 45 96 359117 −369 −294 −249 —  11(V) −4283 −4358 −4111 −4394 −3938 −2259 2686−3549 −3219 11 — 275 394 45 96 359 117 −369 −294 −249 —  12(M) −3939−3999 −3423 −3784 −3494 −2217 2073 −2691 −2538 12 — 275 394 45 96 359117 −369 −294 −249 —  13(K) −928 −2252 −275 1432 −1210 −1146 1012 −2378−1932 13 — 275 394 45 96 359 117 −369 −294 −249 —  14(N) 2287 −2427−1298 −1590 −1307 1405 −1004 −2112 −1674 14 — 275 394 45 96 359 117 −369−294 −249 —  15(N) 4348 −3843 −3410 −3792 −3319 −3533 −4568 −4087 −397615 — 275 394 45 96 359 117 −369 −294 −249 —  16(E) −363 2075 −466 −1190−1070 −1278 −2337 −2879 −2244 16 — 275 394 45 96 359 117 −369 −294 −249—  17(D) −575 −2040 −692 −1495 −1057 −1089 1706 −2499 −1874 17 — 275 39445 96 359 117 −369 −294 −249 —  18(M) −425 938 −38 −569 −595 1047 −1187−1968 −1402 18 — 275 394 45 96 359 117 −369 −294 −249 —  19(T) −532−1923 20 1428 1124 1894 −1823 −2313 −1770 19 — 275 394 45 96 359 117−369 −294 −249 —  20(N) 2664 −2000 −273 1178 870 1294 −1909 −2569 −197420 — 275 394 45 96 359 117 −369 −294 −249 —  21(F) −4001 −4411 −3532−4090 −4106 −3362 −1663 −1215 −228 21 — 275 394 45 96 359 117 −369 −294−249 —  22(R) −3731 −4155 −2844 4177 −4178 −4041 −4836 −3949 −4248 22 —275 394 45 96 359 117 −369 −294 −249 —  23(I) −4321 −4336 −3965 −4313−3959 −2342 1650 −3306 −3087 23 — 275 394 45 96 359 117 −369 −294 −249 — 24(F) −3497 −4006 −3383 −3780 −3277 −2708 1235 −1189 −154 24 — 275 39445 96 359 117 −369 −294 −249 —  25(G) −2329 −2632 −3078 −3451 1430 −1486−2782 −4212 −4060 25 — 275 394 45 96 359 117 −369 −294 −249 —  26(P)−4628 4289 −4938 −4749 −4364 −4429 −5313 −4385 −5119 26 — 275 394 45 96359 117 −369 −294 −249 —  27(D) −2584 −3886 −3102 −4252 −3662 −4000−5151 −4434 −4544 27 — 275 394 45 96 359 117 −369 −294 −249 —  28(E)−2611 −3875 −3007 −3762 −3630 −3916 −4960 −4357 −4463 28 — 275 394 45 96359 117 −369 −294 −249 —  29(T) 1393 −2396 −1299 −1587 −1239 2910 −1154−2256 −1801 29 — 275 394 45 96 359 117 −369 −294 −249 —  30(M) −693−1975 −349 −862 779 −773 −1304 −2139 −1601 30 — 275 394 45 96 359 117−369 −294 −249 —  31(S) −2859 −3095 −3512 −3692 3619 −2088 −3285 −4091−3959 31 — 275 394 45 96 359 117 −369 −294 −249 —  32(N) 4348 −3843−3410 −3792 −3319 −3533 −4568 −4087 −3976 32 — 275 394 45 96 359 117−369 −294 −249 —  33(R) −1934 −3162 −654 3328 −2667 −2432 −3373 −2988−2947 33 — 275 394 45 96 359 117 −369 −294 −249 —  34(L) −4708 −4504−3649 −4284 −4539 −3272 −1347 −2103 −1550 34 — 275 394 45 96 359 117−369 −294 −249 —  35(W) 1385 −1904 1561 −644 −770 −849 −1946 3634 −177335 — 275 394 45 96 359 117 −369 −294 −249 —  36(A) −592 −2329 −693 −1651−1350 −1580 −2804 −3429 −2615 36 — 275 394 45 96 359 117 −369 −294 −249—  37(V) −2204 −2668 −2000 −2237 −1650 1119 2408 −1689 −1335 37 — 275394 45 96 359 117 −369 −294 −249 —  38(F) −3313 −4388 −3349 −3926 −3759−3730 −2762 −269 3290 38 — 275 394 45 96 359 117 −369 −294 −249 —  39(E)−1041 −2696 −830 −750 −1870 −2023 −3182 −3392 −2873 39 — 275 394 45 96359 117 −369 −294 −249 —  40(V) −1760 −2533 −1690 −1904 −1385 −1234 2825−2172 −1669 40 — 275 394 45 96 359 117 −369 −294 −249 —  41(T) −2268−2512 −2898 −3156 2152 3197 −2486 −3990 −3777 41 — 275 394 45 96 359 117−369 −294 −249 —  42(K) 1311 −2012 −114 −440 −908 −975 −2076 −2562 183742 — 275 394 45 96 359 117 −369 −294 −249 —  43(R) −1936 −3164 −657 3395−2670 −2434 −3375 −2990 −2949 43 — 275 394 45 96 359 117 −369 −294 −249—  44(Q) −1026 −2253 3209 −1142 −1159 −1127 −1521 −1673 −859 44 — 275394 45 96 359 117 −369 −294 −249 —  45(W) −4620 −4317 −4639 −4390 −4998−4881 −4870 6237 −1984 45 — 275 394 45 96 359 117 −369 −294 −249 — 46(M) −1756 −2427 −1420 −1731 −1438 1257 −98 −1343 −990 46 — 275 394 4596 359 117 −369 −294 −249 —  47(M) 1285 −1749 1468 −420 684 −616 −1678−2276 −1612 47 — 275 394 45 96 359 117 −369 −294 −249 —  48(Q) −340−1806 1749 −411 −642 −696 453 −2362 −1699 48 — 275 394 45 96 359 117−369 −294 −249 —  49(Y) −2345 −2866 −2105 −2314 −1913 1335 −38 −13652756 49 — 275 394 45 96 359 117 −369 −294 −249 —  50(K) −761 −2285 −505−815 −1266 −1304 −1990 −2658 −2071 50 — 275 394 45 96 359 117 −369 −294−249 —  51(P) 1447 2218 −481 −1251 890 −1302 −2487 −3099 −2347 51 — 275394 45 96 359 117 −369 −294 −249 —  52(P) −590 2271 −556 −1245 −978−1128 −2169 −2938 −2278 52 — 275 394 45 96 359 117 −369 −294 −249 — 53(N) 2542 −2188 −576 −1502 −1234 −1435 −2399 −3048 −2264 53 — 275 39445 96 359 117 −369 −294 −249 —  54(D) −255 −1834 1955 −808 −781 −8711155 −2428 −1753 54 — 275 394 45 96 359 117 −369 −294 −249 —  55(D) −289−2233 −743 −2210 −1458 −1880 −3289 −3847 −2846 55 — 275 394 45 96 359117 −369 −294 −249 —  56(G) −1048 −1555 −1281 −1496 −708 −838 −1625−1974 −1993 56 — 275 394 45 96 359 117 −369 −294 −249 —  57(G) −1048−1555 −1281 −1496 −708 −838 −1625 −1974 −1993 57 — 275 394 45 96 359 117−369 −294 −249 —  58(E) −1602 −2663 −1361 −1800 −1658 −1319 1113 −1614−909 58 — 275 394 45 96 359 117 −369 −294 −249 —  59(H) 1195 −2382 −1248−1495 −1381 −874 −319 −1292 −847 59 — 275 394 45 96 359 117 −369 −294−249 —  60(M) −2240 −2790 −1938 −2186 2108 −1323 −630 −1840 −1502 60 —275 394 45 96 359 117 −369 −294 −249 —  61(P) 1487 2266 −1625 −2185−1038 −1207 −2349 −3511 −3060 61 — 275 394 45 96 359 117 −369 −294 −249—  62(D) −324 −1796 94 1124 −630 −691 543 −2379 −1707 62 — 275 394 45 96359 117 −369 −294 −249 —  63(R) −382 −1834 11 1567 −698 1155 −1794 −2375−1748 63 — 275 394 45 96 359 117 −369 −294 −249 —  64(G) −2708 −3407−2316 2444 −2556 −2650 −3716 −3837 −3878 64 — 275 394 45 96 359 117 −369−294 −249 —  65(R) −1532 −2759 1746 2935 −1945 −1744 −2067 −2537 −224765 — 275 394 45 96 359 117 −369 −294 −249 —  66(V) −4339 −4440 −4385−4597 −3992 −2250 3374 −3973 −3489 66 — 275 394 45 96 359 117 −369 −294−249 —  67(M) −1485 −2308 −1135 −1498 −1282 1243 1140 −1394 −1015 67 —275 394 45 96 359 117 −369 −294 −249 —  68(E) −934 −2595 −1219 −21641764 −1926 −3163 −3855 −3091 68 — 275 394 45 96 359 117 −369 −294 −249 — 69(M) −2427 −2930 2286 −2331 −2034 −1279 1529 −1766 −1445 69 — 275 39445 96 359 117 −369 −294 −249 —  70(L) −4891 −4508 −4152 −4395 −4705−3767 −1993 −3125 −3069 70 — 275 394 45 96 359 117 −369 −294 −249 — 71(S) −2859 −3095 −3512 −3692 3619 −2088 −3285 −4091 −3959 71 — 275 39445 96 359 117 −369 −294 −249 —  72(E) −2611 −3875 −3007 −3762 −3630−3916 −4960 −4357 −4463 72 — 275 394 45 96 359 117 −369 −294 −249 — 73(H) −4130 −4378 −4151 −3893 −4548 −4592 −5195 −3383 −2818 73 — 275394 45 96 359 117 −369 −294 −249 —  74(Q) −1415 −2454 2378 −1119 −14031904 −979 −1998 −1592 74 — 275 394 45 96 359 117 −369 −294 −249 —  75(C)−2492 −2705 −2686 −2861 −1458 −1303 −805 −2559 −2242 75 — 275 394 45 96359 117 −369 −294 −249 —  76(E) −859 −2659 2792 −1646 −1832 −2117 −3370−3761 −3011 76 — 275 394 45 96 359 117 −369 −294 −249 —  77(G) −4417−4223 −4850 −4766 −3952 −4069 −5125 −4424 −5214 77 — 275 394 45 96 359117 −369 −294 −249 —  78(W) −3403 −4509 −3506 −4073 −3950 −4146 −33145352 877 78 — 275 394 45 96 359 117 −369 −294 −249 —  79(L) −5098 −4540−3683 −4317 −4734 −3229 −1208 −2698 −2837 79 — 275 394 45 96 359 117−369 −294 −249 —  80(E) −868 −2687 2032 −1753 −1875 −2180 −3447 −3837−3070 80 — 275 394 45 96 359 117 −369 −294 −249 —  81(G) −2462 −2643−3254 −3542 −1260 −1474 −2727 −4214 −4140 81 — 275 394 45 96 359 117−369 −294 −249 —  82(Y) −3884 −4503 −3998 −4255 −4336 −4491 −4072 −11774829 82 — 275 394 45 96 359 117 −369 −294 −249 —  83(L) −3150 −3415−2899 −3072 −2469 2215 −950 −2583 −2364 83 — 275 394 45 96 359 117 −369−294 −249 —  84(L) −4891 −4508 −4152 −4395 −4705 −3767 −1993 −3125 −306984 — 275 394 45 96 359 117 −369 −294 −249 —  85(T) −3291 −3408 −3829−3824 −2338 3976 −3321 −4129 −4203 85 — 275 394 45 96 359 117 −369 −294−249 —  86(G) −4417 −4223 −4850 −4766 −3952 −4069 −5125 −4424 −5214 86 —275 394 45 96 359 117 −369 −294 −249 —  87(R) −3731 −4155 −2844 4177−4178 −4041 −4836 −3949 −4248 87 — 275 394 45 96 359 117 −369 −294 −249—  88(H) −1952 −2860 −1941 −1889 −1744 2351 −2641 −2857 −2142 88 — 275394 45 96 359 117 −369 −294 −249 —  89(G) −2476 −2666 −3269 −3560 −1290−1506 −2760 −4228 −4161 89 — 275 394 45 96 359 117 −369 −294 −249 — 90(F) −2851 −3158 −2477 −2735 −2341 −1496 −62 −1785 −1478 90 — 275 39445 96 359 117 −369 −294 −249 —  91(F) −3389 −4515 −3495 −4075 −3946−4154 −3320 3520 904 91 — 275 394 45 96 359 117 −369 −294 −249 —  92(A)−2174 1760 −2697 −3044 2014 −1242 −2447 −3930 −3709 92 — 275 394 45 96359 117 −369 −294 −249 —  93(S) −2356 −2477 −3023 −3254 2975 1394 −2305−3830 −3649 93 — 275 394 45 96 359 117 −369 −294 −249 —  94(Y) −3884−4503 −3998 −4255 −4336 −4491 −4072 −1177 4829 94 — 275 394 45 96 359117 −369 −294 −249 —  95(E) −2611 −3875 −3007 −3762 −3630 −3916 −4960−4357 −4463 95 — 275 394 45 96 359 117 −369 −294 −249 —  96(A) −2338−2505 −3081 −3355 2536 −1295 −2531 −4108 −3950 96 — 275 394 45 96 359117 −369 −294 −249 —  97(F) −4147 −4512 −4243 −4506 −4433 −4439 −3737−1500 −417 97 — 275 394 45 96 359 117 −369 −294 −249 —  98(M) −2801−3121 −2481 −2711 −2285 −1405 1421 −1846 −1550 98 — 275 394 45 96 359117 −369 −294 −249 —  99(H) −1338 −2617 −548 2281 −1696 1373 −2439 −2662−2280 99 — 275 394 45 96 359 117 −369 −294 −249 — 100(I) −4377 −4472−4432 −4647 −4052 −2257 2744 −4024 −3536 100 — 275 394 45 96 359 117−369 −294 −249 — 101(V

−4370 −4467 −4427 −4640 −4043 −2254 3105 −4021 −3531 101 — 275 394 45 96359 117 −369 −294 −249 — 102(D

−1118 −2459 −1191 −1938 −1365 1158 1286 −3025 −2452 102 — 275 394 45 96359 117 −369 −294 −249 — 103(S) −2859 −3095 −3512 −3692 3619 −2088 −3285−4091 −3959 103 — 275 394 45 96 359 117 −369 −294 −249 — 104(M

−4331 −4225 −4184 −4072 −3938 −3655 −2653 −3435 −3236 104 — 275 394 4596 359 117 −369 −294 −249 — 105(L) −3990 −3978 −3290 −3710 −3525 −23481287 −2465 −2367 105 — 275 394 45 96 359 117 −369 −294 −249 — 106(N

2935 −2420 −1580 −1960 −1182 2024 1339 −2731 −2304 106 — 275 394 45 96359 117 −369 −294 −249 — 107(Q

−3349 −4049 4526 −2916 −3829 −3917 −4726 −3973 −3953 107 — 275 394 45 96359 117 −369 −294 −249 — 108(H

−3097 −4295 −3109 −3362 −3663 −3868 −3403 −373 2757 108 — 275 394 45 96359 117 −369 −294 −249 — 109(A

−1875 −2365 −1993 −2375 1314 −1085 −1685 −2841 −2472 109 — 275 394 45 96359 117 −369 −294 −249 — 110(K

−3130 −3916 −2292 −1410 −3723 −3624 −4465 −3818 −3998 110 — 275 394 4596 359 117 −369 −294 −249 — 111(W

−3425 −4503 −3523 −4074 −3959 −4140 −3310 5693 837 111 — 275 394 45 96359 117 −369 −294 −249 — 112(L) −4959 −4514 −3738 −4340 −4596 −3057 −761−2778 −2863 112 — 275 394 45 96 359 117 −369 −294 −249 — 113(K

−477 −2021 −141 1183 −924 −1014 −2183 −2682 −2014 113 — 275 394 45 96359 117 −369 −294 −249 — 114(M

−1834 −2427 1221 −1791 −1444 −817 1168 −1289 −933 114 — 275 394 45 96359 117 −369 −294 −249 — 115(C

−2336 −2465 −2960 −3214 −1051 2263 −2200 −3668 −3472 115 — 275 394 45 96359 117 −369 −294 −249 — 116(V

−1684 −2156 −1608 −1741 −1222 −711 2811 −1682 −1223 116 — 275 394 45 96359 117 −369 −294 −249 — 117(R

−1028 −2151 −588 2555 747 −902 −1223 −2081 −1631 117 — 275 394 45 96 359117 −369 −294 −249 — 118(E) −534 −2279 1614 −1462 −1295 −1511 −2766−3331 −2516 118 — 275 394 45 96 359 117 −369 −294 −249 — 119(I) −2034−2633 1279 −1920 −1682 1280 −126 −1499 −1169 119 — 275 394 45 96 359 117−369 −294 −249 — 120(P) 1466 2619 −497 −899 −1126 −1246 −2362 −2960−2322 120 — 275 394 45 96 359 117 −369 −294 −249 — 121(W

−5071 −4661 −5108 −4833 −5506 −5369 −5443 6261 −2535 121 — 275 394 45 96359 117 −369 −294 −249 — 122(R

−2048 −3245 −942 3648 −2697 −2534 −3415 −2888 −2551 122 — 275 394 45 96359 117 −369 −294 −249 — 123(H

−565 −1991 −22 1309 −873 −899 −1971 −2431 −1856 123 — 275 394 45 96 359117 −369 −294 −249 — 124(D

−689 2225 −827 −1652 −1548 −1805 −3056 −3598 −2798 124 — 275 394 45 96359 117 −369 −294 −249 — 125(I) −3131 −3919 −3037 −3465 −3182 −2704−1420 −513 2319 125 — 275 394 45 96 359 117 −369 −294 −249 — 126(S)−2048 1372 −2426 −2827 1999 −1206 −2419 −3840 −3573 126 — 275 394 45 96359 117 −369 −294 −249 — 127(S) −2859 −3095 −3512 −3692 3619 −2088 −3285−4091 −3959 127 — 275 394 45 96 359 117 −369 −294 −249 — 128(L) −4542−4330 −3660 −4145 −4094 −2781 1324 −2793 −2769 128 — 275 394 45 96 359117 −369 −294 −249 — 129(N

4348 −3843 −3410 −3792 −3319 −3533 −4568 −4087 −3976 129 — 275 394 45 96359 117 −369 −294 −249 — 130(Y

−2936 −3238 −2574 −2829 −2438 −1554 1298 −1825 2867 130 — 275 394 45 96359 117 −369 −294 −249 — 131(I) −4331 −4311 −3863 −4246 −3955 −2391 1749−3152 −2992 131 — 275 394 45 96 359 117 −369 −294 −249 — 132(M

−1733 −2301 −1435 −1691 561 1254 1172 −1134 −779 132 — 275 394 45 96 359117 −369 −294 −249 — 133(T) −2263 −2509 −2888 −3152 2652 2778 −2491−3995 −3782 133 — 275 394 45 96 359 117 −369 −294 −249 — 134(S) −2859−3095 −3512 −3692 3619 −2088 −3285 −4091 −3959 134 — 275 394 45 96 359117 −369 −294 −249 — 135(H

1437 −2343 −837 −1206 −1244 2636 −2214 −2810 −2158 135 — 275 394 45 96359 117 −369 −294 −249 — 136(W

−3322 −3697 −3202 −3309 −2906 −2265 3288 3612 −961 136 — 275 394 45 96359 117 −369 −294 −249 — 137(W

−2810 −3571 −2764 −3122 −2642 −2381 −1804 5259 566 137 — 275 394 45 96359 117 −369 −294 −249 — 138(R

−1547 −2868 2539 3022 −2145 −2019 −2993 −2838 −2604 138 — 275 394 45 96359 117 −369 −294 −249 — 139(Q

−3349 −4049 4526 −2916 −3829 −3917 −4726 −3973 −3953 139 — 275 394 45 96359 117 −369 −294 −249 — 140(D

−765 −2745 −1300 −2954 −2017 −2495 −3974 −4514 −3455 140 — 275 394 45 96359 117 −369 −294 −249 — 141(H

−4130 −4378 −4151 −3893 −4548 −4592 −5195 −3383 −2818 141 — 275 394 4596 359 117 −369 −294 −249 — 142(N

4348 −3843 −3410 −3792 −3319 −3533 −4568 −4087 −3976 142 — 275 394 45 96359 117 −369 −294 −249 — 143(G

−4417 −4223 −4850 −4766 −3952 −4069 −5125 −4424 −5214 143 — 275 394 4596 359 117 −369 −294 −249 — 144(F) −3328 −4541 −3456 −4078 −3931 −4217−3400 −178 3260 144 — 275 394 45 96 359 117 −369 −294 −249 — 145(T)−2263 −2509 −2888 −3152 2652 2778 −2491 −3995 −3782 145 — 275 394 45 96359 117 −369 −294 −249 — 146(H

−4130 −4378 −4151 −3893 −4548 −4592 −5195 −3383 −2818 146 — 275 394 4596 359 117 −369 −294 −249 — 147(Q

−3349 −4049 4526 −2916 −3829 −3917 −4726 −3973 −3953 147 — 275 394 45 96359 117 −369 −294 −249 — 148(D

−963 −2715 −1470 −2900 1255 −2206 −3561 −4288 −3412 148 — 275 394 45 96359 117 −369 −294 −249 — 149(P) −4628 4289 −4938 −4749 −4364 −4429 −5313−4385 −5119 149 — 275 394 45 96 359 117 −369 −294 −249 — 150(G

−2780 −3430 −2492 1875 −2564 −2676 −3754 −3904 −3964 150 — 275 394 45 96359 117 −369 −294 −249 — 151(F) −3737 −3789 −3040 −3446 −3256 −2245 1216−2175 −2011 151 — 275 394 45 96 359 117 −369 −294 −249 — 152(I) −3529−3714 −3075 −3381 −3054 1098 51 −2437 −2237 152 — 275 394 45 96 359 117−369 −294 −249 — 153(D

−857 −2246 −848 −1597 985 2152 −2413 −3246 −2588 153 — 275 394 45 96 359117 −369 −294 −249 — 154(H

−1770 −2496 −1555 −1734 −1385 1395 2407 −1879 −1430 154 — 275 394 45 96359 117 −369 −294 −249 — 155(M

−3161 −3396 −2699 −2998 −2660 −1749 −182 −2022 −1814 155 — 275 394 45 96359 117 −369 −294 −249 — 156(L) −3196 −3443 −2879 −3157 −2606 −1799 1329−2351 −2114 156 — 275 394 45 96 359 117 −369 −294 −249 — 157(N

2977 −2426 −804 −1905 1148 −1804 −3115 −3698 −2808 157 — 275 394 45 96359 117 −369 −294 −249 — 158(K

−2005 −3159 −1028 −200 −2490 −2293 −2474 −2837 −2553 158 — 275 394 45 96359 117 −369 −294 −249 — 159(K

−1076 −2295 −623 −548 886 1179 −2234 −2851 −2379 159 — 275 394 45 96 359117 −369 −294 −249 — 160(P) −1781 2897 −1813 −2195 966 −1055 −1493 −2567−2152 160 — 275 394 45 96 359 117 −369 −294 −249 — 161(D

1701 −2586 −1055 −2452 −1771 −2164 −3570 −4160 −3154 161 — 275 394 45 96359 117 −369 −294 −249 — 162(N

3292 −1450 −280 −647 −522 −670 −1383 −1763 −1178 162 — 275 394 45 96 359117 −369 −294 −249 — 163(D

34 −1523 −264 −1242 −811 −1065 −1927 −2232 −1739 163 — 275 394 45 96 359117 −369 −294 −249 — 164(H

−676 −1756 −466 −415 −1034 −1055 −1464 −790 42 164 — 275 394 45 96 359117 −369 −294 −249 — 165(V

−3954 −4126 −3800 −4049 −3566 −2094 2791 −3155 −2717 165 — 275 394 45 96359 117 −369 −294 −249 — 166(V

−2383 −2845 −2193 −2434 949 1115 2471 −1913 −1547 166 — 275 394 45 96359 117 −369 −294 −249 — 167(R

1602 −3079 −997 3685 −2367 −2329 −3316 −3168 −2942 167 — 275 394 45 96359 117 −369 −294 −249 — 168(I) −2364 −2914 1287 −2345 −1977 −1221 2181−1906 −1534 168 — 275 394 45 96 359 117 −369 −294 −249 — 169(Y

−3884 −4503 −3998 −4255 −4336 −4491 −4072 −1177 4829 169 — 275 394 45 96359 117 −369 −294 −249 — 170(F) −4506 −4471 −3608 −4224 −4409 −3268−1403 −1851 −1138 170 — 275 394 45 96 359 117 −369 −294 −249 — 171(P)−2502 3818 −3181 −3412 −1407 −1613 −2766 −4124 −4023 171 — 275 394 45 96359 117 −369 −294 −249 — 172(P) −2204 3083 −2726 −3028 −1065 1432 −2336−3823 −3602 172 — 275 394 45 96 359 117 −369 −294 −249 — 173(D

−2584 −3886 −3102 −4252 −3662 −4000 −5151 −4434 −4544 173 — 275 394 4596 359 117 −369 −294 −249 — 174(A

−2297 −2499 −2833 −3104 −1111 −1235 1120 −3514 −3272 174 — 275 394 45 96359 117 −369 −294 −249 — 175(N

4348 −3843 −3410 −3792 −3319 −3533 −4568 −4087 −3976 175 — 275 394 45 96359 117 −369 −294 −249 — 176(C

−1909 −2363 −1881 −2164 925 2536 −890 −2035 −1692 176 — 275 394 45 96359 117 −369 −294 −249 — 177(L) −4659 −4495 −3638 −4269 −4506 −3269−1359 −2041 −1444 177 — 275 394 45 96 359 117 −369 −294 −249 — 178(L)−4891 −4508 −4152 −4395 −4705 −3767 −1993 −3125 −3069 178 — 275 394 4596 359 117 −369 −294 −249 — 179(C

−2414 −2485 −3185 −3403 1168 −1242 −2356 −3925 −3779 179 — 275 394 45 96359 117 −369 −294 −249 — 180(V

−3830 −4052 −3798 −4000 −3390 1338 2999 −3399 −2963 180 — 275 394 45 96359 117 −369 −294 −249 — 181(F) −2019 −2485 −1821 −2060 −1435 1085 1429−1479 −1117 181 — 275 394 45 96 359 117 −369 −294 −249 — 182(D

−670 −2570 −1045 −2378 −1733 −2102 −3453 −4073 −3107 182 — 275 394 45 96359 117 −369 −294 −249 — 183(H

−1745 −3017 −555 2597 −2412 −2222 −3187 −2907 −2791 183 — 275 394 45 96359 117 −369 −294 −249 — 184(C

−2602 −2717 −3092 −3274 −1392 −1333 1279 −3175 −2885 184 — 275 394 45 96359 117 −369 −294 −249 — 185(M

−4767 −4399 −3550 −4175 −4399 −3050 −1206 −2449 −2343 185 — 275 394 4596 359 117 −369 −294 −249 — 186(Q

−1292 −2679 3064 193 −1845 −1787 −2819 −2820 −2501 186 — 275 394 45 96359 117 −369 −294 −249 — 187(S) −1042 −2342 −1143 −1916 2458 2054 −2488−3434 −2812 187 — * * * * * * * * * —

indicates data missing or illegible when filed

TABLE 9 HMMER2.0 [2.3.2] NAME XFP C ACC PF09363.1 DESC XFP C-terminaldomain LENG 212 ALPH Amino RF no CS no MAP yes COM hmmbuild -f -F HMMfs.ann SEED.ann COM hmmcalibrate -- seed 0 HMM fs.ann NSEQ 6 DATE ThuMay 3 17:57:02 2007 CKSUM 5491 GA 25.0 25.0 TC 47.0 29.4 NC 15.7 15.7 XT−8455 −4 −1000 −1000 −8455 −4 −8455 −4 NULT −4 −8455 NULE 595 −1558 85338 −294 453 −1158 197 249 902 −1085 −142 −21 −313 45 531 201 384 −1998−644 EVD −10.483098 0.640397 A C D E F G H I K HMM m->m m->i m->d i->mi->i d->m d->d b->m m->e L M N P Q R S T V W Y −193 * −2999  1(K) −4125−4091 −4017 −3615 −5101 −3960 −2958 −5182 3972 −4825 −4345 −3552 −4249−2709 −1809 −4154 −4044 −4895 −4132 −4389 1 — −149 −500 233 43 −381 399106 −626 210 −466 −720 275 394 45 96 359 117 −369 −294 −249 — −12 −7945−8987 −894 −1115 −701 −1378 −1193 −8721  2(Q) −1392 −2802 −618 −424−3105 −2084 2223 −2893 −446 −2828 −1977 1616 1057 3114 −866 −1245 −1350−2468 −2957 −2283 2 — −149 −500 233 43 −381 399 106 −626 210 −466 −720275 394 45 96 359 117 −369 −294 −249 — −12 −7945 −8987 −894 −1115 −701−1378 −8914 −8718  3(P) 1097 −2000 −3515 −3791 −4319 −2230 −3513 −4117−3884 −4378 −3565 −2801 3889 −3540 −3757 −1661 −1871 −3066 −4416 −4363 3— −149 −500 233 43 −381 399 106 −626 210 −466 −720 275 394 45 96 359 117−369 −294 −249 — −12 −7945 −8987 −894 −1115 −701 −1378 −8914 −8714  4(H)829 −2314 −845 −285 −2656 −1910 2103 −2366 0 −2324 −1434 −569 −2003 17142028 709 −889 −1956 −2490 −1870 4 — −149 −500 233 43 −381 399 106 −626210 −466 −720 275 394 45 96 359 117 −369 −294 −249 — −12 −7945 −8987−894 −1115 −701 −1378 −8914 −8711  5(W) 872 −1301 −1524 −969 −1324 −2103−863 −924 −771 407 −486 −1096 1119 2314 −1087 −1098 −833 −778 2741 −12335 — −149 −500 233 43 −381 399 106 −626 210 −466 −720 275 394 45 96 359117 −369 −294 −249 — −12 −7945 −8987 −894 −1115 −701 −1378 −8914 −8707 6(Q) 1139 −1910 −1850 −1613 −3267 −2003 −1790 −2923 −1462 −3080 −2266−1578 −2518 3569 −1755 −1258 1437 −2329 −3351 −2895 6 — −149 −500 233 43−381 399 106 −626 210 −466 −720 275 394 45 96 359 117 −369 −294 −249 —−12 −7945 −8987 −894 −1115 −701 −1378 −8914 −8704  7(W) −4606 −3595−5007 −5318 253 −4844 −1211 −3574 −4838 −2908 −2986 −3590 −4756 −3710−4268 −4192 −4482 −3721 5473 3368 7 — −149 −500 233 43 −381 399 106 −626210 −466 −720 275 394 45 96 359 117 −369 −294 −249 — −12 −7945 −8987−894 −1115 −701 −1378 −8914 −8700  8(L) −2343 −2040 −4542 −3937 1831−4019 −2749 1548 −3592 2218 65 −3613 −3780 1482 −3353 −3156 −2252 −936−2180 −1956 8 — −149 −500 233 43 −381 399 106 −626 210 −466 −720 275 39445 96 359 117 −369 −294 −249 — −12 −7945 −8987 −894 −1115 −701 −1378−8914 −8697  9(T) −1385 −2322 1417 −1149 −3726 −2036 −1831 −3500 −1823−3585 −2754 −1314 −2593 −1510 −2340 1921 2800 −2796 −3801 −3184 9 — −149−500 233 43 −381 399 106 −626 210 −466 −720 275 394 45 96 359 117 −369−294 −249 — −12 −7945 −8987 −894 −1115 −701 −1378 −8914 −8693  10(M)−1554 −1399 −3470 −2849 −1043 −3109 −1939 −255 1071 1028 3713 −2584−3080 −2156 −2304 −2204 −1488 1337 −1856 −1572 10 — −149 −500 233 43−381 399 106 −626 210 −466 −720 275 394 45 96 359 117 −369 −294 −249 —−12 −7945 −8987 −894 −1115 −701 −1378 −8914 −8690  11(D) −2255 −40802935 2308 −4312 −2253 −1576 −4208 −1768 −4097 −3398 −854 −2767 −1236−2584 −1939 1141 −3689 −4293 −3313 11 — −149 −500 233 43 −381 399 106−626 210 −466 −720 275 394 45 96 359 117 −369 −294 −249 — −12 −7945−8987 −894 −1115 −701 −1378 −8914 −8687  12(E) −1169 −2634 −621 2512−2971 −1972 −696 −2711 1193 −2634 −1746 −602 −2134 1564 −675 777 −1111−2271 −2782 −2114 12 — −149 −500 233 43 −381 399 106 −626 210 −466 −720275 394 45 96 359 117 −369 −294 −249 — −12 −7945 −8987 −894 −1115 −701−1378 −8914 −8683  13(A) 3176 −1703 −4006 −4070 −3246 −2260 −3401 −1441−3823 −2722 −2304 −2855 −2973 −3487 −3663 −1620 −1659 1420 −3901 −363113 — −149 −500 233 43 −381 399 106 −626 210 −466 −720 275 394 45 96 359117 −369 −294 −249 — −12 −7945 −8987 −894 −1115 −701 −1378 −8914 −8679 14(I) −1158 −1549 −1727 1889 −1669 −2385 −1107 1890 −836 −1344 −736−1323 −2456 −885 1317 −1399 −1097 1018 −2055 −1611 14 — −149 −500 233 43−381 399 106 −626 210 −466 −720 275 394 45 96 359 117 −369 −294 −249 —−12 −7945 −8987 −894 −1115 −701 −1378 −8914 −8676  15(H) 848 −2322 −1179−560 −2630 −2119 2363 −2275 2038 −2278 −1446 −801 −2188 −233 1325 −1089−1073 627 −2469 −1939 15 — −149 −500 233 43 −381 399 106 −626 210 −466−720 275 394 45 96 359 117 −369 −294 −249 — −12 −7945 −8987 −894 −1115−701 −1378 −8914 −8672  16(H) −1354 −2628 −576 1333 −2749 −2068 3770−2560 −570 422 −1777 1432 −2292 −513 −1032 −1235 −1312 −2213 −2778 −209916 — −149 −500 233 43 −381 399 106 −626 210 −466 −720 275 394 45 96 359117 −369 −294 −249 — −12 −7945 −8987 −894 −1115 −701 −1378 −8914 −8669 17(C) 947 4245 −3771 −3246 −1380 −2866 −2176 −26 −2899 843 −500 −2705−3040 −2556 −2758 −2038 −1382 1326 −2062 −1723 17 — −149 −500 233 43−381 399 106 −626 210 −466 −720 275 394 45 96 359 117 −369 −294 −249 —−12 −7945 −8987 −894 −1115 −701 −1378 −8914 −8665  18(T) −1296 −2623−1140 1900 −3034 −2174 −690 −2702 1486 −2593 −1730 −817 −2254 −245 1344−1174 1932 −2302 −2686 −2143 18 — −149 −500 233 43 −381 399 106 −626 210−466 −720 275 394 45 96 359 117 −369 −294 −249 — −12 −7945 −8987 −894−1115 −701 −1378 −8914 −8662  19(A) 2122 −2640 1402 −254 −2963 −1940−736 −2715 1187 −2660 −1774 −577 −2132 1562 −869 −1024 −1125 −2273 −2833−2136 19 — −149 −500 233 43 −381 399 106 −626 210 −466 −720 275 394 4596 359 117 −369 −294 −249 — −12 −7945 −8987 −894 −1115 −701 −1378 −8914−8658  20(G) −4088 −3924 −4774 −5139 −5615 3825 −4753 −6303 −5453 −6014−5662 −4812 −4539 −5232 −5106 −4370 −4472 −5527 −4696 −5561 20 — −149−500 233 43 −381 399 106 −626 210 −466 −720 275 394 45 96 359 117 −369−294 −249 — −12 −7945 −8987 −894 −1115 −701 −1378 −8914 −8655  21(I)1832 −1779 −4707 −4321 −2320 −4169 −3857 2857 −4145 −1329 −1156 −3958−4165 −3960 −4165 −3443 −2157 1658 −3571 −3143 21 — −149 −500 233 43−381 399 106 −626 210 −466 −720 275 394 45 96 359 117 −369 −294 −249 —−12 −7945 −8987 −894 −1115 −701 −1378 −8914 −8651  22(A) 1979 −2132 1358−1230 −3624 895 −1764 −3399 −1659 −3464 −2589 −1343 −2501 −1420 −21381914 −1456 −2656 −3665 −3086 22 — −149 −500 233 43 −381 399 106 −626 210−466 −720 275 394 45 96 359 117 −369 −294 −249 — −12 −7945 −8987 −894−1115 −701 −1378 −8914 −8647  23(I) −1613 −1432 −3370 991 −1684 −3301−2327 2219 −2660 −1128 −723 −2715 −3318 −2464 −2756 −2418 1220 2185−2433 −2038 23 — −149 −500 233 43 −381 399 106 −626 210 −466 −720 275394 45 96 359 117 −369 −294 −249 — −12 −7945 −8987 −894 −1115 −701 −1378−8914 −8644  24(W) −3333 −2943 −4821 −4705 −865 −4258 −2319 1550 −4105−1483 −1550 −3928 −4360 −3731 −3856 −3853 −3350 −1751 5765 −662 24 —−149 −500 233 43 −381 399 106 −626 210 −466 −720 275 394 45 96 359 117−369 −294 −249 — −12 −7945 −8987 −894 −1115 −701 −1378 −8914 −8640 25(D) −2155 −3941 2895 1331 −4165 −2244 −1467 −4031 2266 −3906 −3170−838 −2712 −1110 −2170 −1857 −2186 −3532 −4076 −3168 25 — −149 −500 23343 −381 399 106 −626 210 −466 −720 275 394 45 96 359 117 −369 −294 −249— −12 −7945 −8988 −894 −1115 −701 −1378 −8914 −8637  26(W) −4535 −3580−5043 −5339 2264 −4800 −1315 −3404 −4909 −2727 −2820 −3667 −4744 −3774−4331 −4221 −4434 −3613 5781 611 26 — −149 −500 233 43 −381 399 106 −626210 −466 −720 275 394 45 96 359 117 −369 −294 −249 — −12 −7945 −8988−894 −1115 −701 −1378 −8914 −8633  27(A) 3609 −2508 −4184 −4493 −4592−2737 −3989 −4421 −4496 −4701 −4051 −3440 −3474 −4171 −4253 −2294 −2487−3536 −4484 −4643 27 — −149 −500 233 43 −381 399 106 −626 210 −466 −720275 394 45 96 359 117 −369 −294 −249 — −12 −7945 −8988 −894 −1115 −701−1378 −8914 −8629  28(S) −1944 −2458 −3696 −4011 −4410 −2644 −3753 −4675−4191 −4807 −4070 −3198 −3384 −3886 −4051 3656 −2393 −3615 −4374 −430728 — −149 −500 233 43 −381 399 106 −626 210 −466 −720 275 394 45 96 359117 −369 −294 −249 — −12 −7945 −8988 −894 −1115 −701 −1378 −8914 −8626 29(N) −1462 −2164 −1894 −2122 −3935 −2171 −2578 −3801 −2603 −4009 −32303172 −2856 −2392 −2846 −1616 2907 −2960 −4077 −3633 29 — −149 −500 23343 −381 399 106 −626 210 −466 −720 275 394 45 96 359 117 −369 −294 −249— −12 −7945 −8988 −894 −1115 −701 −1378 −8914 −8622  30(D) 2036 −30923356 −1144 −4437 −2344 −2201 −4300 −2537 −4380 −3702 −1420 −2974 −1935−3248 −2004 −2335 −3577 −4473 −3774 30 — −149 −500 233 43 −381 399 106−626 210 −466 −720 275 394 45 96 359 117 −369 −294 −249 — −12 −7945−8988 −894 −1115 −701 −1378 −8914 −8618  31(K) 719 −2804 1286 −282 −3133−1980 −846 −2900 2557 −2836 −1958 1613 −2216 −421 −1059 −1135 −1263−2444 −3007 −2283 31 — −149 −500 233 43 −381 399 106 −626 210 −466 −720275 394 45 96 359 117 −369 −294 −249 — −12 −7945 −8988 −894 −1115 −701−1378 −8914 −8615  32(G) −1795 −2851 1703 −1000 −4330 2898 −2022 −4220−2294 −4229 −3471 −1259 −2791 −1732 −2991 1182 −2066 −3405 −4399 −363332 — −149 −500 233 43 −381 399 106 −626 210 −466 −720 275 394 45 96 359117 −369 −294 −249 — −1206 −7945 −837 −894 −1115 −701 −1378 −8914 −8611 33(N) −713 −1555 −300 −476 −2841 2208 −1131 −2756 −1105 −2843 −20742836 −1863 −861 −1525 −760 −971 −2081 −2888 −2349 33 — −149 −500 233 43−381 399 106 −626 210 −466 −720 275 394 45 96 359 117 −369 −294 −249 —−24 −6764 −7806 −894 −1115 −162 −3231 −8914 −8607  34(E) 652 −2550 13832004 −2857 −1868 −643 −2618 −298 −2563 −1660 −497 −2040 1542 −832 −908985 −2168 −2738 −2028 34 — −149 −500 233 43 −381 399 106 −626 210 −466−720 275 394 45 96 359 117 −369 −294 −249 — −12 −7945 −8988 −894 −1115−701 −1378 −8914 −8604  35(E) 978 −3351 −336 2983 −3871 −2170 −1425−3692 −1401 −3640 −2859 1765 −2619 −1063 −2043 −1667 −1932 −3175 −3830−3006 35 — −149 −500 233 43 −381 399 106 −626 210 −466 −720 275 394 4596 359 117 −369 −294 −249 — −12 −7945 −8988 −894 −1115 −701 −1378 −8914−8600  36(P) −1823 −2153 −3843 −3947 −3271 −2734 −3495 −1581 −3785 −2766−2465 −3169 3446 −3607 −3696 −2195 −2168 2328 −3859 −3579 36 — −149 −500233 43 −381 399 106 −626 210 −466 −720 275 394 45 96 359 117 −369 −294−249 — −12 −7945 −8988 −894 −1115 −701 −1378 −8914 −8596  37(D) −2642−4390 3693 −696 −4628 −2447 −1891 −4714 −2203 −4552 −3980 −1088 −30191971 −3045 −2293 −2745 −4173 −4588 −3642 37 — −149 −500 233 43 −381 399106 −626 210 −466 −720 275 394 45 96 359 117 −369 −294 −249 — −12 −7945−8988 −894 −1115 −701 −1378 −8914 −8592  38(V) −2557 −2122 −5071 −4711−1962 −4673 −4220 320 −4512 984 −791 −4445 −4483 −4165 −4454 −4020 −25503348 −3513 −3210 38 — −149 −500 233 43 −381 399 106 −626 210 −466 −720275 394 45 96 359 117 −369 −294 −249 — −12 −7945 −8988 −894 −1115 −701−1378 −8914 −8589  39(V) −2838 −2616 −4834 −4880 −3213 −3955 −4416 −610−4757 −2310 −2253 −4383 −4345 −4643 −4642 −3732 −3007 3763 −4157 −388639 — −149 −500 233 43 −381 399 106 −626 210 −466 −720 275 394 45 96 359117 −369 −294 −249 — −12 −7946 −8988 −894 −1115 −701 −1378 −8914 −8585 40(M) −3038 −2583 −5400 −4796 1866 −4936 −3671 2288 −4513 1389 3379−4610 −4379 −3590 −4127 −4157 −2917 −1104 −2668 −2694 40 — −149 −500 23343 −381 399 106 −626 210 −466 −720 275 394 45 96 359 117 −369 −294 −249— −13 −7946 −8988 −894 −1115 −701 −1378 −8914 −8581  41(A) 3609 −2508−4184 −4493 −4592 −2737 −3989 −4421 −4496 −4701 −4051 −3440 −3474 −4171−4253 −2294 −2487 −3536 −4484 −4643 41 — −149 −500 233 43 −381 399 106−626 210 −466 −720 275 394 45 96 359 117 −369 −294 −249 — −13 −7946−8988 −894 −1115 −701 −1378 −8914 −8577  42(C) 2065 2925 −3988 −4043−3973 1287 −3331 −3726 −3772 −3993 −3088 −2601 −2687 −3352 −3601 2060−1451 −2653 −4224 −4091 42 — −149 −500 233 43 −381 399 106 −626 210 −466−720 275 394 45 96 359 117 −369 −294 −249 — −13 −7946 −8988 −894 −1115−701 −1378 −8914 −8574  43(A) 2866 2846 −4109 −4001 −2791 −2206 −3077−1268 −3662 −2419 −1888 −2761 −2871 −3275 −3465 −1533 −1500 1398 −3377−3097 43 — −149 −500 233 43 −381 399 106 −626 210 −466 −720 275 394 4596 359 117 −369 −294 −249 — −13 −7946 −8988 −894 −1115 −701 −1378 −8914−8570  44(G) −4088 −3924 −4774 −5139 −5615 3825 −4753 −6303 −5453 −6014−5662 −4812 −4539 −5232 −5106 −4370 −4472 −5527 −4696 −5561 44 — −149−500 233 43 −381 399 106 −626 210 −466 −720 275 394 45 96 359 117 −369−294 −249 — −13 −7946 −8988 −894 −1115 −701 −1378 −8914 −8566  45(D)1008 −3741 3309 −578 −4350 −2242 −1698 −4254 −1941 −4177 −3484 1820−2795 −1375 −2757 −1930 −2306 −3665 −4371 −3418 45 — −149 −500 233 43−381 399 106 −626 210 −466 −720 275 394 45 96 359 117 −369 −294 −249 —−13 −7946 −8988 −894 −1115 −701 −1378 −8914 −8562  46(V) −1488 −1444−2805 1912 −1672 −3036 −1995 1499 −2149 −1163 −719 −2290 −3083 −1996−2352 −2120 998 2130 −2347 −1936 46 — −149 −500 233 43 −381 399 106 −626210 −466 −720 275 394 45 96 359 117 −369 −294 −249 — −13 −7946 −8988−894 −1115 −701 −1378 −8914 −8558  47(P) −2288 −2497 −3856 −3931 −2960−3134 −3483 1588 −3705 −2343 −2229 −3416 3829 −3629 −3645 −2690 −2575−1605 −3649 −3323 47 — −149 −500 233 43 −381 399 106 −626 210 −466 −720275 394 45 96 359 117 −369 −294 −249 — −13 −7946 −8988 −894 −1115 −701−1378 −8914 −8555  48(T) −1494 −1874 −3613 −3499 −2448 −2472 −2890 −1675−3034 −1763 2674 −2770 −3069 −2947 −2983 −1828 3524 −1602 −3212 −2888 48— −149 −500 233 43 −381 399 106 −626 210 −466 −720 275 394 45 96 359 117−369 −294 −249 — −13 −7946 −8988 −894 −1115 −701 −1378 −8914 −8551 49(F) −1077 −1060 −2607 −2006 1617 −2517 −1308 1338 853 1327 −74 −1856−2554 1561 −1724 −1568 −1013 −416 −1457 −1095 49 — −149 −500 233 43 −381399 106 −626 210 −466 −720 275 394 45 96 359 117 −369 −294 −249 — −13−7946 −8988 −894 −1115 −701 −1378 −8914 −8547  50(E) −4205 −4417 −23433901 −5349 −3698 −3534 −5837 −3838 −5561 −5237 −3039 −4218 −3453 −4201−4072 −4352 −5409 −4640 −4860 50 — −149 −500 233 43 −381 399 106 −626210 −466 −720 275 394 45 96 359 117 −369 −294 −249 — −13 −7946 −8988−894 −1115 −701 −1378 −8914 −8543  51(T) 1578 −1365 −3818 −3310 −1660−3164 −2456 1709 −3026 −1148 −726 −2898 −3288 −2750 −2975 −2334 20311609 −2396 −2024 51 — −149 −500 233 43 −381 399 106 −626 210 −466 −720275 394 45 96 359 117 −369 −294 −249 — −13 −7946 −8988 −894 −1115 −701−1378 −8914 −8539  52(M) −3164 −2670 −5546 −4970 −1172 −5167 −3972 −395−4712 2611 2735 −4857 −4533 −3759 −4329 −4434 −3047 1340 −2847 −2936 52— −149 −500 233 43 −381 399 106 −626 210 −466 −720 275 394 45 96 359 117−369 −294 −249 — −13 −7946 −8988 −894 −1115 −701 −1378 −8914 −8535 53(A) 3164 −2290 −2449 −2301 −3900 −2380 −2191 −3516 1483 −3644 −2906−2112 −2939 −1904 −1531 −1776 −1904 −2880 −3730 −3462 53 — −149 −500 23343 −381 399 106 −626 210 −466 −720 275 394 45 96 359 117 −369 −294 −249— −13 −7946 −8988 −894 −1115 −701 −1378 −8914 −8531  54(A) 3609 −2508−4184 −4493 −4592 −2737 −3989 −4421 −4496 −4701 −4051 −3440 −3474 −4171−4253 −2294 −2487 −3536 −4484 −4643 54 — −149 −500 233 43 −381 399 106−626 210 −466 −720 275 394 45 96 359 117 −369 −294 −249 — −13 −7946−8988 −894 −1115 −701 −1378 −8914 −8527  55(V) 950 −941 −2811 −2248−1031 −2327 −1422 −440 −1962 740 −250 −1933 −2494 −1690 −1964 896 10791807 −1521 −1165 55 — −149 −500 233 43 −381 399 106 −626 210 −466 −720275 394 45 96 359 117 −369 −294 −249 — −13 −7946 −8988 −894 −1115 −701−1378 −8914 −8524  56(H) 659 −2340 1265 1241 −2654 −1788 2240 −2406 −89−2353 −1435 −421 −1907 1509 −604 −738 910 −1959 −2525 −1836 56 — −149−500 233 43 −381 399 106 −626 210 −466 −720 275 394 45 96 359 117 −369−294 −249 — −13 −7946 −8988 −894 −1115 −701 −1378 −8914 −8520  57(M) 905−1698 −4314 −3724 −1143 −3706 −2623 2145 −3388 1126 3388 −3345 −3578−2895 −3189 −2841 −1918 −295 −2218 −2005 57 — −149 −500 233 43 −381 399106 −626 210 −466 −720 275 394 45 96 359 117 −369 −294 −249 — −13 −7946−8988 −894 −1115 −701 −1378 −8914 −8516  58(L) −3094 −2629 −5472 −5009−1335 −5054 −4133 −266 −4744 2900 −148 −4850 −4577 −3917 −4430 −4403−3029 1404 −3024 −3024 58 — −149 −500 233 43 −381 399 106 −626 210 −466−720 275 394 45 96 359 117 −369 −294 −249 — −13 −7946 −8988 −894 −1115−701 −1378 −8914 −8512  59(N) −1718 −2924 −1536 −943 −3401 −2491 2272−3022 67 −2851 −2042 2480 −2560 1853 2240 −1589 −1584 −2659 −2864 −242659 — −149 −500 233 43 −381 399 106 −626 210 −466 −720 275 394 45 96 359117 −369 −294 −249 — −13 −7946 −8988 −894 −1115 −701 −1378 −8914 −8508 60(Q) −1303 −2782 −604 1957 −3121 −2037 −786 −2861 1397 −2771 −18951587 −2225 2403 −741 −1147 −1246 −2420 −2908 −2240 60 — −149 −500 233 43−381 399 106 −626 210 −466 −720 275 394 45 96 359 117 −369 −294 −249 —−13 −7946 −8988 −894 −1115 −701 −1378 −8914 −8504  61(M) −836 −1314 1097−815 1234 −2045 2007 −937 −682 −1198 2233 −976 −2124 1369 −1042 −1018−776 996 −1675 −1208 61 — −149 −500 233 43 −381 399 106 −626 210 −466−720 275 394 45 96 359 117 −369 −294 −249 — −13 −7946 −8988 −894 −1115−701 −1378 −8914 −8500  62(F) −1264 −1055 −3592 −2980 2448 801 −17701523 −2606 732 −96 −2510 −2888 −2223 −2426 −1975 −1207 1242 −1588 −125162 — −149 −500 233 43 −381 399 106 −626 210 −466 −720 275 394 45 96 359117 −369 −294 −249 — −267 −7946 −2622 −894 −1115 −701 −1378 −8914 −8496 63(P) −4031 −3755 −4476 −4814 −5166 −3783 −4422 −5849 −5008 −5560 −5299−4583 4287 −4894 −4709 −4316 −4383 −5266 −4354 −5078 63 — −149 −500 23343 −381 399 106 −626 210 −466 −720 275 394 45 96 359 117 −369 −294 −249— −14 −7693 −8735 −894 −1115 −1509 −624 −8914 −8492  64(E) −1699 −34251700 2340 −3660 −1960 −1101 −3504 −1077 −3405 −2608 1773 −2370 2059−1764 −1441 −1711 −3013 −3587 −2715 64 — −149 −500 233 43 −381 399 106−626 210 −466 −720 275 394 45 96 359 117 −369 −294 −249 — −14 −7693−8735 −894 −1115 −358 −2187 −8914 −8488  65(L) 891 −2044 −4713 −4184−1318 −4146 −3223 1658 −3880 2504 −198 −3858 −3970 −3332 −3681 −3346−2320 −337 −2643 −2499 65 — −149 −500 233 43 −381 399 106 −626 210 −466−720 275 394 45 96 359 117 −369 −294 −249 — −13 −7946 −8988 −894 −1115−701 −1378 −8914 −8484  66(R) −3030 −3584 −3982 −2344 −4551 −3458 −1269−3800 2924 −3397 −2757 −2153 −3376 −852 3034 −2903 −2656 −3598 −3188−3160 66 — −149 −500 233 43 −381 399 106 −626 210 −466 −720 275 394 4596 359 117 −369 −294 −249 — −13 −7946 −8988 −894 −1115 −701 −1378 −8914−8480  67(F) −2326 −1891 −4869 −4440 2685 −4485 −3701 2340 −4251 −921−863 −4124 −4292 −3931 −4198 −3737 −2296 2290 −3181 −2708 67 — −149 −500233 43 −381 399 106 −626 210 −466 −720 275 394 45 96 359 117 −369 −294−249 — −13 −7946 −8988 −894 −1115 −701 −1378 −8914 −8476  68(R) −3054−3592 −3980 −2373 −4560 −3469 −1297 −3823 1781 −3421 −2785 −2179 −3395−881 3702 −2930 −2684 −3621 −3206 −3181 68 — −149 −500 233 43 −381 399106 −626 210 −466 −720 275 394 45 96 359 117 −369 −294 −249 — −13 −7946−8988 −894 −1115 −701 −1378 −8914 −8472  69(F) −3145 −2644 −4628 −45162787 −4252 −1269 −1824 −4116 −1928 −1754 −3303 −4186 −3281 −3729 −3432−3069 2671 −580 2537 69 — −149 −500 233 43 −381 399 106 −626 210 −466−720 275 394 45 96 359 117 −369 −294 −249 — −13 −7946 −8988 −894 −1115−701 −1378 −8914 −8468  70(V) −2450 −1960 −5111 −4795 −2565 −4880 −48551914 −4732 −1343 −1286 −4581 −4668 −4656 −4868 −4252 −2448 3379 −4256−3756 70 — −149 −500 233 43 −381 399 106 −626 210 −466 −720 275 394 4596 359 117 −369 −294 −249 — −13 −7946 −8988 −894 −1115 −701 −1378 −8914−8464  71(N) −1525 −2287 −1522 −1828 −4053 −2153 −2507 −4149 −2667 −4251−3455 3942 −2849 −2311 −3012 1045 −1898 −3178 −4209 −3651 71 — −149 −500233 43 −381 399 106 −626 210 −466 −720 275 394 45 96 359 117 −369 −294−249 — −13 −7946 −8988 −894 −1115 −701 −1378 −8914 −8459  72(V) −2838−2616 −4834 −4880 −3213 −3955 −4416 −610 −4757 −2310 −2253 −4383 −4345−4643 −4642 −3732 −3007 3763 −4157 −3886 72 — −149 −500 233 43 −381 399106 −626 210 −466 −720 275 394 45 96 359 117 −369 −294 −249 — −13 −7946−8988 −894 −1115 −701 −1378 −8914 −8455  73(V) −2243 −1824 −4833 −4454−2402 −4433 −4113 1762 −4305 −1350 −1201 −4152 −4338 −4160 −4358 −37221258 3104 −3760 −3307 73 — −149 −500 233 43 −381 399 106 −626 210 −466−720 275 394 45 96 359 117 −369 −294 −249 — −13 −7946 −8988 −894 −1115−701 −1378 −8914 −8451  74(D) −2668 −4634 3697 1529 −4809 −2393 −1860−4835 −2286 −4663 −4116 −996 −2985 −1560 −3281 −2276 −2774 −4274 −4791−3728 74 — −149 −500 233 43 −381 399 106 −626 210 −466 −720 275 394 4596 359 117 −369 −294 −249 — −13 −7946 −8988 −894 −1115 −701 −1378 −8914−8447  75(L) −3647 −3060 −5937 −5371 −1118 −5682 −4333 −610 −5087 30012533 −5429 −4784 −3925 −4592 −5073 −3493 −1435 −2916 −3081 75 — −149−500 233 43 −381 399 106 −626 210 −466 −720 275 394 45 96 359 117 −369−294 −249 — −13 −7946 −8988 −894 −1115 −701 −1378 −8914 −8443  76(M)−1722 −1497 −3954 −3355 −1014 848 −2243 1549 −2997 978 3830 −2966 −3285−2560 −2824 −2460 −1661 −398 −1947 −1696 76 — −149 −500 233 43 −381 399106 −626 210 −466 −720 275 394 45 96 359 117 −369 −294 −249 — −13 −7946−8988 −894 −1115 −701 −1378 −8914 −8439  77(K) −1675 −2604 −1914 −1147−3023 −2553 −912 −2542 2655 −2539 −1775 −1279 −2595 −506 1666 −1628 1008985 −2674 −2295 77 — −149 −500 233 43 −381 399 106 −626 210 −466 −720275 394 45 96 359 117 −369 −294 −249 — −13 −7946 −8988 −894 −1115 −701−1378 −8914 −8435  78(L) −4119 −3542 −5389 −5357 −2027 −4767 −4358 −1609−5118 3293 −979 −5230 −4771 −4474 −4724 −5069 −4106 −2331 −3412 −3400 78— −149 −500 233 43 −381 399 106 −626 210 −466 −720 275 394 45 96 359 117−369 −294 −249 — −13 −7946 −8988 −894 −1115 −701 −1378 −8914 −8430 79(Q) −1357 −2106 −1510 −1196 −2392 −2243 −1288 −2153 −824 371 −1573−1327 −2535 3535 −1081 1033 −1413 −1913 −2627 −2087 79 — −149 −500 23343 −381 399 106 −626 210 −466 −720 275 394 45 96 359 117 −369 −294 −249— −13 −7946 −8988 −894 −1115 −701 −1378 −8914 −8426  80(P) −1393 −2284−1577 −1362 −3557 −2164 −1558 −3266 1432 −3269 −2444 −1443 2774 −1192−1186 2003 −1560 −2662 −3389 −2924 80 — −149 −500 233 43 −381 399 106−626 210 −466 −720 275 394 45 96 359 117 −369 −294 −249 — −13 −7946−8988 −894 −1115 −701 −1378 −8914 −8422  81(K) −1010 −2349 −767 1764−2657 −1927 −589 −2362 1961 301 −1468 −584 −2042 −153 −523 917 −946−1969 −2533 −1906 81 — −149 −500 233 43 −381 399 106 −626 210 −466 −720275 394 45 96 359 117 −369 −294 −249 — −13 −7946 −8988 −894 −1115 −701−1378 −8914 −8418  82(H) −956 −2424 −615 1087 −2749 −1853 2292 −24942040 −2432 −1522 1288 −1978 −92 −585 753 −897 −2050 −2592 −1916 82 —−149 −500 233 43 −381 399 106 −626 210 −466 −720 275 394 45 96 359 117−369 −294 −249 — −1873 −7946 −474 −894 −1115 −701 −1378 −8914 −8414 83(G) −853 −1186 −1419 −1603 −2565 3376 −1668 −2627 −1844 −2759 −2200−1431 −1859 −1709 −1902 −1054 −1192 −2034 −2282 −2387 83 — −149 −500 23343 −381 399 106 −626 210 −466 −720 275 394 45 96 359 117 −369 −294 −249— −36 −6109 −7151 −894 −1115 −2826 −219 −8914 −8409  84(A) 2862 −488−1346 −1349 −1807 −785 −1257 −1119 −1298 −1627 −1088 −934 −1428 −1183−1403 −201 −309 −714 −2107 −1798 84 — −149 −500 233 43 −381 399 106 −626210 −466 −720 275 394 45 96 359 117 −369 −294 −249 — −36 −6109 −7151−894 −1115 −2826 −219 −8914 −8405  85(L) −1446 −1261 −2639 −2396 −166−2529 −1687 443 −1969 2652 716 −2264 −2607 −1810 −1925 −2083 −1460 71−1338 −963 85 — −149 −500 233 43 −381 399 106 −626 210 −466 −720 275 39445 96 359 117 −369 −294 −249 — −36 −6109 −7151 −894 −1115 −431 −1952−8914 −8401  86(E) −1620 −3077 −205 2781 −2713 −2016 −1027 −3107 −935−3054 −2295 1905 −2376 −703 −1502 −1416 −1618 −2704 −2909 1972 86 — −149−500 233 43 −381 399 106 −626 210 −466 −720 275 394 45 96 359 117 −369−294 −249 — −15 −7696 −8738 −894 −1115 −1502 −628 −8914 −8397  87(H)−1687 −3020 −524 −508 −3027 −2149 4043 −3137 −478 −3027 −2263 1907 −24462055 −794 −1508 −1649 −2742 −2951 −2237 87 — −149 −500 233 43 −381 399106 −626 210 −466 −720 275 394 45 96 359 117 −369 −294 −249 — −15 −7696−8738 −894 −1115 −360 −2179 −8914 −8392  88(P) −2450 −4345 1816 1516−4562 −2311 −1714 −4514 −2022 −4375 −3745 −914 3318 −1394 −2920 −2098−2536 −3971 −4556 −3521 88 — −149 −500 233 43 −381 399 106 −626 210 −466−720 275 394 45 96 359 117 −369 −294 −249 — −13 −7946 −8988 −894 −1115−701 −1378 −8914 −8388  89(H) −2178 −3297 −1451 1311 −3729 −2695 4349−3419 −165 −3210 −2472 −1349 −2852 −755 1705 −2018 −2038 −3087 −3149−2733 89 — −149 −500 233 43 −381 399 106 −626 210 −466 −720 275 394 4596 359 117 −369 −294 −249 — −13 −7946 −8988 −894 −1115 −701 −1378 −8914−8384  90(G) 1135 −2508 −960 1390 −3988 2880 −1982 −3774 −2052 −3851−3054 −1368 −2715 −1683 −2580 −1591 −1835 −3036 −4050 −3424 90 — −149−500 233 43 −381 399 106 −626 210 −466 −720 275 394 45 96 359 117 −369−294 −249 — −13 −7946 −8988 −894 −1115 −701 −1378 −8914 −8379  91(M)−3620 −3042 −5906 −5341 −1118 −5639 −4298 −608 −5051 2656 3645 −5383−4766 −3909 −4566 −5021 −3469 −1425 −2906 −3062 91 — −149 −500 233 43−381 399 106 −626 210 −466 −720 275 394 45 96 359 117 −369 −294 −249 —−13 −7946 −8988 −894 −1115 −701 −1378 −8914 −8375  92(S) −1385 −2104−1840 −2115 −4039 −2094 −2642 −4072 −2802 −4207 −3375 1808 −2809 −2466−3073 3255 −1780 −3055 −4205 −3726 92 — −149 −500 233 43 −381 399 106−626 210 −466 −720 275 394 45 96 359 117 −369 −294 −249 — −13 −7946−8988 −894 −1115 −701 −1378 −8914 −8371  93(D) −2954 −4081 3777 −1338−4930 −2812 −2481 −5106 −2896 −4959 −4423 −1697 1695 −2236 −3689 −2728−3134 −4489 −4667 −4137 93 — −149 −500 233 43 −381 399 106 −626 210 −466−720 275 394 45 96 359 117 −369 −294 −249 — −13 −7946 −8988 −894 −1115−701 −1378 −8914 −8366  94(R) 847 −2632 −1132 2003 −3046 −2175 −695−2716 1321 −2604 −1741 −819 −2258 −250 2101 −1179 −1206 −2313 −2696−2152 94 — −149 −500 233 43 −381 399 106 −626 210 −466 −720 275 394 4596 359 117 −369 −294 −249 — −13 −7946 −8988 −894 −1115 −701 −1378 −8914−8362  95(D) −2629 −4604 3009 2799 −4770 −2374 −1828 −4782 −2234 −4614−4051 −973 −2960 −1523 −3216 −2241 −2730 −4224 −4757 −3689 95 — −149−500 233 43 −381 399 106 −626 210 −466 −720 275 394 45 96 359 117 −369−294 −249 — −13 −7946 −8988 −894 −1115 −701 −1378 −8914 −8358  96(F)−4587 −3562 −5019 −5350 4191 −4887 −1144 −3464 −4916 −2789 −2878 −3547−4760 −3678 −4301 −4156 −4453 −3634 −393 2478 96 — −149 −500 233 43 −381399 106 −626 210 −466 −720 275 394 45 96 359 117 −369 −294 −249 — −13−7946 −8988 −894 −1115 −701 −1378 −8914 −8353  97(D) 988 −3875 2907 1483−4100 −2208 −1447 −3972 −1539 −3865 −3114 1567 −2675 −1089 −2294 −1800−2126 −3467 −4055 −3126 97 — −149 −500 233 43 −381 399 106 −626 210 −466−720 275 394 45 96 359 117 −369 −294 −249 — −13 −7946 −8988 −894 −1115−701 −1378 −8914 −8349  98(S) 1458 −2457 1399 −292 −2897 −1890 −750−2648 1311 −2615 −1722 −599 −2098 −317 −922 1668 −1053 −2187 −2800 −211398 — −149 −500 233 43 −381 399 106 −626 210 −466 −720 275 394 45 96 359117 −369 −294 −249 — −13 −7946 −8988 −894 −1115 −701 −1378 −8914 −8344 99(L) −3562 −3022 −4998 −4839 −384 −4758 −2089 −1358 −4382 2908 −731−3989 −4502 −3590 −4015 −4103 −3467 −1964 −1321 2369 99 — −149 −500 23343 −381 399 106 −626 210 −466 −720 275 394 45 96 359 117 −369 −294 −249— −13 −7946 −8988 −894 −1115 −701 −1378 −8914 −8340 100(F) −4720 −3927−5139 −5454 4513 −4504 −2520 −3938 −5326 −3307 −3429 −4469 −4782 −4575−4818 −4787 −4810 −4172 −1812 −736 100 — −149 −500 233 43 −381 399 106−626 210 −466 −720 275 394 45 96 359 117 −369 −294 −249 — −13 −7946−8988 −894 −1115 −701 −1378 −8914 −8335 101(T) −1345 −1936 −3485 −3748−4307 1297 −3469 −4115 −3845 −4377 −3519 −2741 −2943 −3484 −3725 −15883638 −3022 −4411 −4351 101 — −149 −500 233 43 −381 399 106 −626 210 −466−720 275 394 45 96 359 117 −369 −294 −249 — −13 −7946 −8988 −894 −1115−701 −1378 −8914 −8331 102(P) 1040 −1933 −1444 −985 −2825 −1942 −1172−2498 1349 −2593 −1749 −1119 2171 −794 −1131 −1051 1955 −2025 −2847−2320 102 — −149 −500 233 43 −381 399 106 −626 210 −466 −720 275 394 4596 359 117 −369 −294 −249 — −13 −7946 −8988 −894 −1115 −701 −1378 −8914−8326 103(D −2253 −3538 3694 −855 −4532 −2334 −2017 −4570 −2397 −4510−3869 −1194 −2951 −1736 −3233 1140 −2471 −3857 −4578 −3695 103 — −149−500 233 43 −381 399 106 −626 210 −466 −720 275 394 45 96 359 117 −369−294 −249 — −1873 −7946 −474 −894 −1115 −701 −1378 −8914 −8322 104(G−853 −1186 −1419 −1603 −2565 3376 −1668 −2627 −1844 −2759 −2200 −1431−1859 −1709 −1902 −1054 −1192 −2034 −2282 −2387 104 — −149 −500 233 43−381 399 106 −626 210 −466 −720 275 394 45 96 359 117 −369 −294 −249 —−36 −6109 −7151 −894 −1115 −133 −3504 −8914 −8317 105(K −2513 −3301−3024 −1871 −4114 −3126 −1139 −3484 3142 −3184 −2485 −1825 −3101 −7171860 −2405 1288 −3220 −3066 −2911 105 — −149 −500 233 43 −381 399 106−626 210 −466 −720 275 394 45 96 359 117 −369 −294 −249 — −13 −7946−8988 −894 −1115 −701 −1378 −8914 −8313 106(P) −3125 −3472 −2885 −3107−3559 −3370 2901 −4916 −3129 −4732 −4256 −3117 3925 −3250 −3218 −3230−3395 −4360 −3686 −3131 106 — −149 −500 233 43 −381 399 106 −626 210−466 −720 275 394 45 96 359 117 −369 −294 −249 — −13 −7946 −8988 −894−1115 −701 −1378 −8914 −8308 107(V −2449 −1961 −5107 −4792 −2559 −4869−4842 1787 −4726 −1338 −1282 −4575 −4662 −4648 −4859 −4241 −2447 3416−4245 −3747 107 — −149 −500 233 43 −381 399 106 −626 210 −466 −720 275394 45 96 359 117 −369 −294 −249 — −13 −7946 −8988 −894 −1115 −701 −1378−8914 −8304 108(I) −2038 −1784 −4073 −3538 −1026 −3659 2506 3064 −30421092 −254 −3185 −3570 −2750 −2918 −2809 −1976 −421 −2001 −1514 108 —−149 −500 233 43 −381 399 106 −626 210 −466 −720 275 394 45 96 359 117−369 −294 −249 — −13 −7946 −8988 −894 −1115 −701 −1378 −8914 −8299109(F) −4720 −3927 −5139 −5454 4513 −4504 −2520 −3938 −5326 −3307 −3429−4469 −4782 −4575 −4818 −4787 −4810 −4172 −1812 −736 109 — −149 −500 23343 −381 399 106 −626 210 −466 −720 275 394 45 96 359 117 −369 −294 −249— −13 −7946 −8988 −894 −1115 −701 −1378 −8914 −8295 110(N 2479 −1867−2193 −2351 −4027 1237 −2680 −3819 −2833 −4000 −3118 2632 −2690 −2487−3076 −1354 −1567 −2811 −4182 −3832 110 — −149 −500 233 43 −381 399 106−626 210 −466 −720 275 394 45 96 359 117 −369 −294 −249 — −13 −7946−8988 −894 −1115 −701 −1378 −8914 −8290 111(Y −4612 −3570 −5027 −53653457 −4900 −1135 −3495 −4928 −2816 −2906 −3544 −4767 −3678 −4307 −4162−4473 −3659 −383 3895 111 — −149 −500 233 43 −381 399 106 −626 210 −466−720 275 394 45 96 359 117 −369 −294 −249 — −13 −7946 −8988 −894 −1115−701 −1378 −8914 −8285 112(H −4836 −4275 −4356 −4629 −3663 −4242 5422−5932 −4492 −5436 −5298 −4579 −4696 −4620 −4352 −5005 −5030 −5648 −3750−3259 112 — −149 −500 233 43 −381 399 106 −626 210 −466 −720 275 394 4596 359 117 −369 −294 −249 — −13 −7946 −8989 −894 −1115 −701 −1378 −8914−8281 113(G 1132 −1656 −3630 −3843 −4215 3045 −3388 −4017 −3845 −4265−3324 −2567 −2709 −3385 −3688 1328 −1497 −2799 −4429 −4315 113 — −149−500 233 43 −381 399 106 −626 210 −466 −720 275 394 45 96 359 117 −369−294 −249 — −13 −7946 −8989 −894 −1115 −701 −1378 −8914 −8276 114(Y−4604 −3569 −5020 −5357 2093 −4892 −1140 −3492 −4921 −2815 −2905 −3546−4764 −3679 −4305 −4160 −4468 −3656 −389 4550 114 — −149 −500 233 43−381 399 106 −626 210 −466 −720 275 394 45 96 359 117 −369 −294 −249 —−13 −7946 −8989 −894 −1115 −701 −1378 −8914 −8271 115(P) 1686 −1775−1257 1192 −2259 −1996 −1137 −1747 −939 −2059 −1306 −1082 2013 −833−1354 −1109 −1078 1053 −2490 −1979 115 — −149 −500 233 43 −381 399 106−626 210 −466 −720 275 394 45 96 359 117 −369 −294 −249 — −13 −7946−8989 −894 −1115 −701 −1378 −8914 −8267 116(W −911 −1979 1204 −354 −1971−1917 2044 −1821 −260 −1921 2147 −627 −2020 1682 −714 −875 −851 −15313682 −1476 116 — −149 −500 233 43 −381 399 106 −626 210 −466 −720 275394 45 96 359 117 −369 −294 −249 — −13 −7946 −8989 −894 −1115 −701 −1378−8914 −8262 117(D −1595 −2205 2386 −1132 −2251 −2360 −1616 −1668 −16721961 −1361 −1358 −2717 −1399 −2106 −1703 1087 −1603 −2785 −2280 117 —−149 −500 233 43 −381 399 106 −626 210 −466 −720 275 394 45 96 359 117−369 −294 −249 — −13 −7946 −8989 −894 −1115 −701 −1378 −8914 −8257118(I) −2533 −2040 −5154 −4770 −2133 −4913 −4501 3201 −4662 936 −891−4572 −4602 −4354 −4667 −4240 −2507 1754 −3764 −3470 118 — −149 −500 23343 −381 399 106 −626 210 −466 −720 275 394 45 96 359 117 −369 −294 −249— −13 −7946 −8989 −894 −1115 −701 −1378 −8914 −8253 119(H −1221 −2591−1040 1217 −2989 −2108 3064 −2676 1463 −2566 −1690 1307 −2192 −200 1508−1095 −1130 −2261 −2664 −2094 119 — −149 −500 233 43 −381 399 106 −626210 −466 −720 275 394 45 96 359 117 −369 −294 −249 — −13 −7946 −8989−894 −1115 −701 −1378 −8914 −8248 120(R 862 −2187 −859 −332 −2662 770−616 −2382 −160 −2365 −1469 −604 −1998 1525 1934 922 −871 −1941 −2551−1920 120 — −149 −500 233 43 −381 399 106 −626 210 −466 −720 275 394 4596 359 117 −369 −294 −249 — −14 −7948 −8990 −894 −1115 −701 −1378 −8914−8244 121(L) −3417 −2857 −5787 −5262 −1221 −5526 −4333 1616 −5024 2930−11 −5255 −4747 −3973 −4603 −4899 −3296 −959 −2997 −3107 121 — −149 −500233 43 −381 399 106 −626 210 −466 −720 275 394 45 96 359 117 −369 −294−249 — −14 −7947 −8989 −894 −1115 −701 −1378 −8914 −8238 122(T) −1746−1500 −4034 −3432 1750 −3391 −2252 1561 −3078 1096 −52 −3017 −3319 −2616−2884 −2508 2450 −353 −1923 −1630 122 — −149 −500 233 43 −381 399 106−626 210 −466 −720 275 394 45 96 359 117 −369 −294 −249 — −14 −7947−8989 −894 −1115 −701 −1378 −8914 −8234 123(Y −4607 −3570 −5022 −53592289 −4894 −1139 −3493 −4923 −2816 −2907 −3546 −4765 −3679 −4305 −4161−4470 −3658 −387 4501 123 — −149 −500 233 43 −381 399 106 −626 210 −466−720 275 394 45 96 359 117 −369 −294 −249 — −14 −7947 −8989 −894 −1115−701 −1378 −8914 −8229 124(D −1348 −2787 2242 −415 −3129 −2090 2199−2863 −263 −2769 −1903 −717 −2264 1787 2067 −1197 −1284 −2435 −2889−2250 124 — −149 −500 233 43 −381 399 106 −626 210 −466 −720 275 394 4596 359 117 −369 −294 −249 — −14 −7947 −8989 −894 −1115 −701 −1378 −8914−8224 125(R −4488 −4181 −4789 −4318 −5193 −4148 −3436 −5568 −2393 −5152−4748 −4156 −4479 −3286 4202 −4614 −4467 −5273 −4267 −4649 125 — −149−500 233 43 −381 399 106 −626 210 −466 −720 275 394 45 96 359 117 −369−294 −249 — −14 −7947 −8989 −894 −1115 −701 −1378 −8914 −8219 126(T)−900 −1750 −1012 977 −1985 754 −770 1034 −516 −1791 −1012 −790 1172 −435−956 −941 1779 −1338 −2179 −1644 126 — −149 −500 233 43 −381 399 106−626 210 −466 −720 275 394 45 96 359 117 −369 −294 −249 — −510 −7947−1783 −894 −1115 −701 −1378 −8914 −8214 127(N −1735 −2957 −337 −503−3341 −2022 −1191 −3403 −833 −3305 −2603 3506 −2459 2336 −1181 −1571−1796 −2939 −3255 −2559 127 — −149 −500 233 43 −381 399 106 −626 210−466 −720 275 394 45 96 359 117 −369 −294 −249 — −17 −7453 −8496 −894−1115 −258 −2612 −8914 −8209 128(H −1956 −3025 −776 −1013 −3561 11554532 −3890 −1721 −3852 −3139 1561 −2848 −1522 −2169 −1872 −2130 −3302−3700 −2914 128 — −149 −500 233 43 −381 399 106 −626 210 −466 −720 275394 45 96 359 117 −369 −294 −249 — −14 −7947 −8989 −894 −1115 −701 −1378−8914 −8205 129(D −1326 −2680 2762 −433 −3190 751 −1003 −2946 −718 −2918−2057 −743 −2295 −594 1178 −1205 1254 −2474 −3108 −2410 129 — −149 −500233 43 −381 399 106 −626 210 −466 −720 275 394 45 96 359 117 −369 −294−249 — −14 −7947 −8989 −894 −1115 −701 −1378 −8914 −8200 130(N −1803−2774 −1319 −1257 −3841 1092 −1554 −3580 −862 −3494 −2719 3434 −2788−1187 1621 −1770 −1905 −3037 −3520 −3054 130 — −149 −500 233 43 −381 399106 −626 210 −466 −720 275 394 45 96 359 117 −369 −294 −249 — −14 −7947−8989 −894 −1115 −701 −1378 −8914 −8195 131(L) −2659 −2243 −5081 −45211845 −4592 −3494 1459 −4246 2227 −106 −4254 −4217 −3540 −3970 −3797−2575 1425 −2707 −2618 131 — −149 −500 233 43 −381 399 106 −626 210 −466−720 275 394 45 96 359 117 −369 −294 −249 — −14 −7947 −8989 −894 −1115−701 −1378 −8914 −8190 132(H −1265 −1465 −2433 −2035 −1445 −2449 37751372 −1614 −1394 −839 −1901 −2701 −1628 −1732 −1623 2191 −807 −1952−1432 132 — −149 −500 233 43 −381 399 106 −626 210 −466 −720 275 394 4596 359 117 −369 −294 −249 — −14 −7947 −8989 −894 −1115 −701 −1378 −8914−8185 133(V −2378 −2013 −4879 −4522 −2020 −4336 −3971 321 −4271 −8612587 −4174 −4288 −3996 −4221 −3659 −2396 3344 −3447 −3110 133 — −149−500 233 43 −381 399 106 −626 210 −466 −720 275 394 45 96 359 117 −369−294 −249 — −14 −7947 −8989 −894 −1115 −701 −1378 −8914 −8180 134(H−1298 −2431 −1191 1210 −2723 −2201 3201 −2373 −52 −2378 −1563 −884 −2290−333 2092 −1222 −1207 912 −2555 −2032 134 — −149 −500 233 43 −381 399106 −626 210 −466 −720 275 394 45 96 359 117 −369 −294 −249 — −14 −7947−8989 −894 −1115 −701 −1378 −8914 −8175 135(G −4088 −3924 −4774 −5139−5615 3825 −4753 −6303 −5453 −6014 −5662 −4812 −4539 −5232 −5106 −4370−4472 −5527 −4696 −5561 135 — −149 −500 233 43 −381 399 106 −626 210−466 −720 275 394 45 96 359 117 −369 −294 −249 — −14 −7947 −8989 −894−1115 −701 −1378 −8914 −8170 136(Y −4791 −3935 −4914 −5231 −815 −4530−2178 −4357 −5024 −3745 −3807 −4206 −4772 −4328 −4584 −4677 −4837 −4435−1477 4857 136 — −149 −500 233 43 −381 399 106 −626 210 −466 −720 275394 45 96 359 117 −369 −294 −249 — −14 −7947 −8989 −894 −1115 −701 −1378−8914 −8165 137(R −2010 −3025 −2206 −1337 −3603 −2773 −965 −3110 2304−2910 2165 1370 −2777 −536 2519 −1900 −1822 −2804 −2890 −2581 137 — −149−500 233 43 −381 399 106 −626 210 −466 −720 275 394 45 96 359 117 −369−294 −249 — −14 −7947 −8989 −894 −1115 −701 −1378 −8914 −8160 138(E)−4205 −4417 −2343 3901 −5349 −3698 −3534 −5837 −3838 −5561 −5237 −3039−4218 −3453 −4201 −4072 −4352 −5409 −4640 −4860 138 — −149 −500 233 43−381 399 106 −626 210 −466 −720 275 394 45 96 359 117 −369 −294 −249 —−14 −7947 −8989 −894 −1115 −701 −1378 −8914 −8155 139(E) −1541 −31431571 2510 −3425 −2060 −1020 −3219 1175 −3136 −2281 −669 −2361 1840 −1368−1340 −1518 −2751 −3304 −2529 139 — −149 −500 233 43 −381 399 106 −626210 −466 −720 275 394 45 96 359 117 −369 −294 −249 — −14 −7947 −8989−894 −1115 −701 −1378 −8914 −8150 140(G −4088 −3924 −4774 −5139 −56153825 −4753 −6303 −5453 −6014 −5662 −4812 −4539 −5232 −5106 −4370 −4472−5527 −4696 −5561 140 — −149 −500 233 43 −381 399 106 −626 210 −466 −720275 394 45 96 359 117 −369 −294 −249 — −14 −7947 −8989 −894 −1115 −701−1378 −8914 −8145 141(T) −1448 −2786 1566 −494 −3406 −2031 −1186 −3187−1023 −3164 −2316 1513 −2396 −794 −1603 1061 2567 −2675 −3364 −2628 141— −149 −500 233 43 −381 399 106 −626 210 −466 −720 275 394 45 96 359 117−369 −294 −249 — −14 −7947 −8989 −894 −1115 −701 −1378 −8914 −8140142(I) −1880 −1845 −4196 −3993 −2337 −3273 −3434 2845 −3687 −1437 −1287−3407 −3652 −3527 −3649 −2612 2766 19 −3410 −3029 142 — −149 −500 233 43−381 399 106 −626 210 −466 −720 275 394 45 96 359 117 −369 −294 −249 —−14 −7947 −8989 −894 −1115 −701 −1378 −8914 −8134 143(T) −1427 −2097−2121 −2355 −3933 −2165 −2713 −3790 −2759 −4026 −3246 1603 −2869 −2560−2943 −1604 3622 −2931 −4094 −3692 143 — −149 −500 233 43 −381 399 106−626 210 −466 −720 275 394 45 96 359 117 −369 −294 −249 — −14 −7947−8989 −894 −1115 −701 −1378 −8914 −8129 144(T) −2430 −2823 −4179 −4462−4591 −3027 −4037 −4454 −4406 −4707 −4191 −3664 −3724 −4237 −4215 −26894010 −3747 −4431 −4588 144 — −149 −500 233 43 −381 399 106 −626 210 −466−720 275 394 45 96 359 117 −369 −294 −249 — −14 −7947 −8989 −894 −1115−701 −1378 −8914 −8124 145(P) −1505 −2080 −3392 −3633 −4254 −2301 −3425−4043 −3658 −4296 −3530 −2794 3850 −3427 −3585 −1744 1558 −3083 −4340−4254 145 — −149 −500 233 43 −381 399 106 −626 210 −466 −720 275 394 4596 359 117 −369 −294 −249 — −14 −7947 −8989 −894 −1115 −701 −1378 −8914−8119 146(F) −3994 −3227 −4915 −5043 3832 −4698 −1205 −2713 −4616 −21322459 −3492 −4563 −3530 −4094 −3916 −3878 −2950 −467 2613 146 — −149 −500233 43 −381 399 106 −626 210 −466 −720 275 394 45 96 359 117 −369 −294−249 — −14 −7947 −8989 −894 −1115 −701 −1378 −8914 −8114 147(D −2625−4424 3697 −649 −4717 −2403 −1898 −4810 −2318 −4653 −4097 1859 −2997−1605 −3282 −2269 −2750 −4226 −4723 −3698 147 — −149 −500 233 43 −381399 106 −626 210 −466 −720 275 394 45 96 359 117 −369 −294 −249 — −14−7947 −8989 −894 −1115 −701 −1378 −8914 −8109 148(M −3455 −2954 −5636−5138 −1157 −5278 −4061 −621 −4736 1276 4790 −5054 −4653 −3832 −4350−4674 −3346 −1354 −2859 −2873 148 — −149 −500 233 43 −381 399 106 −626210 −466 −720 275 394 45 96 359 117 −369 −294 −249 — −14 −7947 −8989−894 −1115 −701 −1378 −8914 −8103 149(M 737 −1039 −2128 −1551 −1071−2251 −1108 −553 −1284 −925 2340 −1505 −2347 −1148 1957 −1292 992 1190−1511 −1125 149 — −149 −500 233 43 −381 399 106 −626 210 −466 −720 275394 45 96 359 117 −369 −294 −249 — −14 −7947 −8989 −894 −1115 −701 −1378−8914 −8098 150(V −1589 −1340 −3842 −3261 −1369 −3310 −2277 1533 −2856−783 2491 −2892 −3292 −2604 1266 −2434 −1540 2552 −2138 −1796 150 — −149−500 233 43 −381 399 106 −626 210 −466 −720 275 394 45 96 359 117 −369−294 −249 — −14 −7947 −8989 −894 −1115 −701 −1378 −8914 −8093 151(C −9482699 −2923 −2314 −734 −2453 −1287 −272 −1969 629 −6 −1970 −2503 2182−1898 −1524 −890 1281 −1253 1875 151 — −149 −500 233 43 −381 399 106−626 210 −466 −720 275 394 45 96 359 117 −369 −294 −249 — −14 −7947−8989 −894 −1115 −701 −1378 −8914 −8087 152(N −1513 −2274 −1534 −1835−4051 −2147 −2506 −4137 −2664 −4241 −3442 3900 −2843 −2309 −3007 1223−1886 −3166 −4207 −3653 152 — −149 −500 233 43 −381 399 106 −626 210−466 −720 275 394 45 96 359 117 −369 −294 −249 — −14 −7947 −8989 −894−1115 −701 −1378 −8914 −8082 153(Q −1078 −2597 1398 1298 −2904 570 −660−2670 1137 −2607 −1702 1544 −2056 1583 −856 −929 −1031 −2214 −2776 −2059153 — −149 −500 233 43 −381 399 106 −626 210 −466 −720 275 394 45 96 359117 −369 −294 −249 — −14 −7947 −8989 −894 −1115 −701 −1378 −8914 −8077154(M −2272 −1957 −4590 −3986 −1077 −4004 −2865 1417 −3652 2191 2665−3646 −3782 −3053 −3407 −3149 1251 −644 −2313 −2179 154 — −149 −500 23343 −381 399 106 −626 210 −466 −720 275 394 45 96 359 117 −369 −294 −249— −14 −7947 −8989 −894 −1115 −701 −1378 −8914 −8071 155(D −2253 −35373692 −855 −4532 −2333 −2017 −4569 −2396 −4510 −3868 −1194 −2951 −1735−3232 1151 −2470 −3856 −4577 −3695 155 — −149 −500 233 43 −381 399 106−626 210 −466 −720 275 394 45 96 359 117 −369 −294 −249 — −14 −7947−8989 −894 −1115 −701 −1378 −8914 −8066 156(R −4488 −4181 −4789 −4318−5193 −4148 −3436 −5568 −2393 −5152 −4748 −4156 −4479 −3286 4202 −4614−4467 −5273 −4267 −4649 156 — −149 −500 233 43 −381 399 106 −626 210−466 −720 275 394 45 96 359 117 −369 −294 −249 — −14 −7947 −8989 −894−1115 −701 −1378 −8914 −8061 157(F) −4608 −3568 −5026 −5363 3806 −4898−1136 −3489 −4926 −2811 −2901 −3545 −4766 −3678 −4306 −4161 −4469 −3654−384 3465 157 — −149 −500 233 43 −381 399 106 −626 210 −466 −720 275 39445 96 359 117 −369 −294 −249 — −14 −7947 −8989 −894 −1115 −701 −1378−8914 −8055 158(H 1044 −2139 −1080 −861 −3017 −1958 3956 −2774 −984−2841 −1992 1421 −2333 −887 −1434 909 −1252 −2260 −3059 −2457 158 — −149−500 233 43 −381 399 106 −626 210 −466 −720 275 394 45 96 359 117 −369−294 −249 — −14 −7947 −8989 −894 −1115 −701 −1378 −8914 −8050 159(L)−1995 −1713 −4228 −3647 −1208 −3730 −2645 1439 −3309 2122 −164 −3321−3602 1641 −3161 −2864 −1930 1443 −2284 −2058 159 — −149 −500 233 43−381 399 106 −626 210 −466 −720 275 394 45 96 359 117 −369 −294 −249 —14 −7947 −8989 −894 −1115 −701 −1378 −8914 −8044 160(A 2383 −1556 −2401−2072 −2208 −2210 −1881 −1266 −1832 −1939 −1334 −1898 −2639 1793 −2020−1435 −1318 1882 −2638 −2245 160 — −149 −500 233 43 −381 399 106 −626210 −466 −720 275 394 45 96 359 117 −369 −294 −249 — −14 −7947 −8989−894 −1115 −701 −1378 −8914 −8039 161(I) 855 −2283 −1296 −661 −2565−2186 −701 1827 1284 −2220 −1411 −884 −2249 1555 1499 −1169 −1126 −1886−2436 −1937 161 — −149 −500 233 43 −381 399 106 −626 210 −466 −720 275394 45 96 359 117 −369 −294 −249 — −14 −7947 −8989 −894 −1115 −701 −1378−8914 −8033 162(D −1082 −2449 2531 −267 −2754 −1915 −698 −2479 1332−2474 2209 −579 −2090 −271 −827 743 −1039 −2075 −2684 −2016 162 — −149−500 233 43 −381 399 106 −626 210 −466 −720 275 394 45 96 359 117 −369−294 −249 — −14 −7947 −8989 −894 −1115 −701 −1378 −8914 −8028 163(V 2572−1717 −4125 −4110 −2971 −2517 −3473 −716 −3875 −2280 −1954 −3032 −3163−3569 −3746 −1871 −1754 2604 −3798 −3481 163 — −149 −500 233 43 −381 399106 −626 210 −466 −720 275 394 45 96 359 117 −369 −294 −249 — −14 −7947−8989 −894 −1115 −701 −1378 −8914 −8022 164(M −2861 −2402 −5299 −4748−1283 −4880 −3804 1499 −4501 2317 2674 −4552 −4398 −3712 −4200 −4119−2770 1228 −2863 −2864 164 — −149 −500 233 43 −381 399 106 −626 210 −466−720 275 394 45 96 359 117 −369 −294 −249 — −14 −7947 −8989 −894 −1115−701 −1378 −8914 −8017 165(Q −2277 −4157 2369 2212 −4337 −2257 −1565−4246 −1745 −4116 −3418 −845 −2768 2820 −2553 −1949 −2331 −3727 −4303−3315 165 — −149 −500 233 43 −381 399 106 −626 210 −466 −720 275 394 4596 359 117 −369 −294 −249 — −14 −7947 −8989 −894 −1115 −701 −1378 −8914−8011 166(W −895 −1130 −1817 −1235 −1105 −2196 2271 −700 −958 627 −3141121 −2263 −882 1030 −1203 −832 1095 2753 −1082 166 — −149 −500 233 43−381 399 106 −626 210 −466 −720 275 394 45 96 359 117 −369 −294 −249 —−14 −7947 −8989 −894 −1115 −701 −1378 −8914 −8006 167(L) 894 −1665 −4454−3932 −1615 −3916 −3023 1762 −3653 2037 −555 −3565 −3811 −3286 −3532−3090 −1967 1475 −2679 −2377 167 — −149 −500 233 43 −381 399 106 −626210 −466 −720 275 394 45 96 359 117 −369 −294 −249 — −14 −7947 −8990−894 −1115 −701 −1378 −8914 −8000 168(P) −1358 −1915 1378 −983 −1290−2313 −1059 −1560 −1164 599 −1093 −1181 2573 −988 −1557 −1458 −1325−1413 −1772 2001 168 — −149 −500 233 43 −381 399 106 −626 210 −466 −720275 394 45 96 359 117 −369 −294 −249 — −14 −7947 −8990 −894 −1115 −701−1378 −8914 −7994 169(H 835 −2044 −983 −412 −2272 −1961 2288 −1925 −107−2006 −1181 −671 −2047 2276 1159 −910 −883 818 −2280 −1718 169 — −149−500 233 43 −381 399 106 −626 210 −466 −720 275 394 45 96 359 117 −369−294 −249 — −14 −7947 −8990 −894 −1115 −701 −1378 −8914 −7989 170(N−2018 −3288 1710 −611 −3318 −2277 −1523 −3152 −1621 1866 −2576 2651−2730 −1220 −2271 −1839 −2066 −2863 −3553 −2765 170 — −149 −500 233 43−381 399 106 −626 210 −466 −720 275 394 45 96 359 117 −369 −294 −249 —−14 −7947 −8990 −894 −1115 −701 −1378 −8914 −7983 171(R −1939 −2994−2042 −1272 −3636 697 −982 −3164 2274 −2958 −2181 −1388 1383 −551 2420−1831 −1784 −2823 −2935 −2603 171 — −149 −500 233 43 −381 399 106 −626210 −466 −720 275 394 45 96 359 117 −369 −294 −249 — −14 −7947 −8990−894 −1115 −701 −1378 −8914 −7977 172(Y −813 −1780 −908 −364 −1941 446−570 −1583 1228 −1731 −928 1199 −1968 −200 −701 −813 1109 664 −2082 1675172 — −149 −500 233 43 −381 399 106 −626 210 −466 −720 275 394 45 96 359117 −369 −294 −249 — −14 −7947 −8990 −894 −1115 −701 −1378 −8914 −7972173(V 1834 −1515 −2997 −2525 −2124 −2365 −2002 −972 −1828 −1816 −1242−2181 −2772 −1966 1207 −1599 −1390 2598 −2580 −2228 173 — −149 −500 23343 −381 399 106 −626 210 −466 −720 275 394 45 96 359 117 −369 −294 −249— −1214 −7948 −834 −894 −1115 −701 −1378 −8914 −7966 174(N 2098 −1102−662 −657 −2411 −1122 −1037 −2101 −916 −2331 −1548 2678 −1684 −766 −1264−457 −604 −1513 −2576 −2066 174 — −149 −500 233 43 −381 399 106 −626 210−466 −720 275 394 45 96 359 117 −369 −294 −249 — −26 −6760 −7802 −894−1115 −2557 −269 −8914 −7960 175(Q −711 −1121 −1177 −831 −1223 −1760−770 −238 −424 −821 −384 −912 −1989 2576 −639 −946 −736 2065 −1698 −1211175 — −149 −500 233 43 −381 399 106 −626 210 −466 −720 275 394 45 96 359117 −369 −294 −249 — −26 −6760 −7802 −894 −1115 −2557 −269 −8914 −7954176(N −707 −1550 −295 −469 −2833 2212 −1124 −2747 −1097 −2834 −2065 2825−1857 −854 −1516 −754 −965 −2073 −2881 −2341 176 — −149 −500 233 43 −381399 106 −626 210 −466 −720 275 394 45 96 359 117 −369 −294 −249 — −686−6760 −1453 −894 −1115 −2557 −269 −8914 −7948 177(L) −1446 −1261 −2639−2396 −166 −2529 −1687 443 −1969 2652 716 −2264 −2607 −1810 −1925 −2083−1460 71 −1338 −963 177 — −149 −500 233 43 −381 399 106 −626 210 −466−720 275 394 45 96 359 117 −369 −294 −249 — −37 −6111 −7153 −894 −1115−435 −1941 −8914 −7943 178(C 1406 3275 −2556 −2171 −2790 2067 −1965−2431 −1828 −2675 −1880 −1777 −2338 −1781 1478 −1008 −1091 −1870 −3029−2681 178 — −149 −500 233 43 −381 399 106 −626 210 −466 −720 275 394 4596 359 117 −369 −294 −249 — −16 −7695 −8737 −894 −1115 −1509 −624 −8914−7937 179(N 1616 −1783 −884 −388 −2121 −1793 −600 −1720 1446 −1882 −10751636 −1951 −220 −618 −795 −775 841 −2206 −1651 179 — −149 −500 233 43−381 399 106 −626 210 −466 −720 275 394 45 96 359 117 −369 −294 −249 —−16 −7695 −8737 −894 −1115 −358 −2187 −8914 −7931 180(H 826 −2030 1249−286 −2281 −1850 2945 −1963 −256 −2046 2137 −570 −1980 −190 −741 713−829 −1630 −2333 −1721 180 — −149 −500 233 43 −381 399 106 −626 210 −466−720 275 394 45 96 359 117 −369 −294 −249 — −15 −7948 −8990 −894 −1115−701 −1378 −8914 −7925 181(L) −1888 −1658 −4011 −3398 1778 −3497 −22791355 1112 2128 −19 −3057 −3387 −2573 −2834 −2608 −1812 −657 −1938 −1655181 — −149 −500 233 43 −381 399 106 −626 210 −466 −720 275 394 45 96 359117 −369 −294 −249 — −15 −7948 −8990 −894 −1115 −701 −1378 −8914 −7919182(C −1582 2847 −3677 −3112 −1572 −3286 −2308 2397 1781 −1057 −639−2820 −3303 −2550 −2691 −2415 −1546 1459 −2297 −1922 182 — −149 −500 23343 −381 399 106 −626 210 −466 −720 275 394 45 96 359 117 −369 −294 −249— −15 −7948 −8990 −894 −1115 −701 −1378 −8914 −7913 183(Q 889 −2895 15011223 −3185 −1975 −867 −2968 −610 −2899 −2019 1640 −2225 2395 −1182 −1154−1298 −2505 −3073 −2320 183 — −149 −500 233 43 −381 399 106 −626 210−466 −720 275 394 45 96 359 117 −369 −294 −249 — −15 −7948 −8990 −894−1115 −701 −1378 −8914 −7907 184(M 624 −2075 −807 1189 −2318 −1853 −499−2000 1304 56 1892 −530 −1940 −75 1281 −778 −783 −1655 −2297 −1689 184 —−149 −500 233 43 −381 399 106 −626 210 −466 −720 275 394 45 96 359 117−369 −294 −249 — −15 −7948 −8990 −894 −1115 −701 −1378 −8914 −7901 185(M−2863 −2466 −4981 −4452 −787 −4528 −2772 −688 −4077 1881 3969 −4038−4163 −3323 −3759 −3712 −2755 −1286 −2008 2156 185 — −149 −500 233 43−381 399 106 −626 210 −466 −720 275 394 45 96 359 117 −369 −294 −249 —−15 −7948 −8990 −894 −1115 −701 −1378 −8914 −7895 186(N 889 −2816 1294−278 −3142 −1979 −855 −2912 2030 −2849 −1972 2349 −2220 −431 −1093 −1140−1272 −2455 −3022 −2293 186 — −149 −500 233 43 −381 399 106 −626 210−466 −720 275 394 45 96 359 117 −369 −294 −249 — −15 −7948 −8990 −894−1115 −701 −1378 −8914 −7889 187(W −912 −2365 1857 1258 −2669 −1819 −525−2416 −128 −2373 −1466 −456 −1946 −77 1280 718 −855 −1981 2923 −1868 187— −149 −500 233 43 −381 399 106 −626 210 −466 −720 275 394 45 96 359 117−369 −294 −249 — −15 −7948 −8990 −894 −1115 −701 −1378 −8914 −7883 188(K−1038 −1343 −1852 −1266 1554 −2283 −1007 −874 2350 −1087 2145 −1336−2361 −894 −1097 −1304 1178 −773 −1689 −1243 188 — −149 −500 233 43 −381399 106 −626 210 −466 −720 275 394 45 96 359 117 −369 −294 −249 — −15−7948 −8990 −894 −1115 −701 −1378 −8914 −7877 189(L) −2298 −2730 −2950−2003 −2607 −3127 −1308 −2182 −152 2394 −1514 −1955 −3117 1691 1757−2379 −2109 −2248 −2689 −2425 189 — −149 −500 233 43 −381 399 106 −626210 −466 −720 275 394 45 96 359 117 −369 −294 −249 — −15 −7948 −8990−894 −1115 −701 −1378 −8914 −7870 190(V −1079 −1178 −2219 953 −1217−2479 −1279 1243 1083 512 −362 −1650 −2531 −1279 −1608 −1507 −1021 1902−1713 −1318 190 — −149 −500 233 43 −381 399 106 −626 210 −466 −720 275394 45 96 359 117 −369 −294 −249 — −15 −7948 −8990 −894 −1115 −701 −1378−8914 −7864 191(E) −1354 −2910 1356 2455 −3203 −1991 −882 −2982 1322−2913 −2038 −608 −2244 −460 −1170 −1178 1230 −2523 −3086 −2339 191 —−149 −500 233 43 −381 399 106 −626 210 −466 −720 275 394 45 96 359 117−369 −294 −249 — −15 −7948 −8990 −894 −1115 −701 −1378 −8914 −7858 192(H995 2611 −2882 −2350 −1156 −2330 3755 1388 −2017 −1028 −400 −2003 −2551−1787 −2019 −1469 −1023 −451 −1652 −1275 192 — −149 −500 233 43 −381 399106 −626 210 −466 −720 275 394 45 96 359 117 −369 −294 −249 — −15 −7948−8990 −894 −1115 −701 −1378 −8914 −7852 193(F) −873 −2098 −751 1196 2231−1853 −534 −2026 −137 −2078 −1223 1242 −1958 −115 1091 −800 953 −1680−2329 −1708 193 — −149 −500 233 43 −381 399 106 −626 210 −466 −720 275394 45 96 359 117 −369 −294 −249 — −15 −7948 −8990 −894 −1115 −701 −1378−8914 −7845 194(Q 684 −2845 −419 1349 −3160 −1991 −875 −2930 −582 −2870−1997 2370 −2238 2528 −1121 −1166 −1300 −2477 −3045 −2315 194 — −149−500 233 43 −381 399 106 −626 210 −466 −720 275 394 45 96 359 117 −369−294 −249 — −15 −7948 −8990 −894 −1115 −701 −1378 −8914 −7839 195(Y−3797 −3103 −4834 −4924 2259 −4579 −1182 −2596 −4505 −2328 −2267 −3426−4481 −3479 −4016 −3789 −3700 1231 −456 4130 195 — −149 −500 233 43 −381399 106 −626 210 −466 −720 275 394 45 96 359 117 −369 −294 −249 — −15−7948 −8990 −894 −1115 −701 −1378 −8914 −7833 196(I) 1842 −1480 −3746−3421 −2131 −2613 −2685 2759 −3142 −1622 −1194 −2759 −3062 −2873 −3093−1882 1362 −243 −2830 −2485 196 — −149 −500 233 43 −381 399 106 −626 210−466 −720 275 394 45 96 359 117 −369 −294 −249 — −15 −7948 −8990 −894−1115 −701 −1378 −8914 −7827 197(C −917 2447 −2927 −2307 −742 −2421−1266 −267 −1915 −627 2390 −1950 −2475 −1643 1928 −1495 −858 1278 −12431688 197 — −149 −500 233 43 −381 399 106 −626 210 −466 −720 275 394 4596 359 117 −369 −294 −249 — −15 −7948 −8990 −894 −1115 −701 −1378 −8914−7820 198(E) −2062 −3846 1749 2650 −4068 −2200 −1423 −3938 −1496 −3829−3070 1774 −2658 −1061 −2241 835 −2093 −3434 −4016 −3094 198 — −149 −500233 43 −381 399 106 −626 210 −466 −720 275 394 45 96 359 117 −369 −294−249 — −15 −7948 −8990 −894 −1115 −701 −1378 −8914 −7814 199(H −1285−2612 −523 1316 −2833 −2011 3126 −2579 −558 −2606 −1772 2447 −2236 −462−1057 −1160 −1248 676 −2824 −2144 199 — −149 −500 233 43 −381 399 106−626 210 −466 −720 275 394 45 96 359 117 −369 −294 −249 — −15 −7948−8990 −894 −1115 −701 −1378 −8914 −7807 200(G −2654 −3212 −2507 −2588−4732 3403 −2707 −4668 1545 −4548 −3892 −2604 −3567 −2456 −2072 −2733−2883 −4011 −4170 −4141 200 — −149 −500 233 43 −381 399 106 −626 210−466 −720 275 394 45 96 359 117 −369 −294 −249 — −15 −7948 −8990 −894−1115 −701 −1378 −8914 −7801 201(Y −818 −1798 1165 976 −1948 −1871 −567748 −261 −1738 −935 −608 −1966 1445 −722 −813 −758 820 −2091 1672 201 —−149 −500 233 43 −381 399 106 −626 210 −466 −720 275 394 45 96 359 117−369 −294 −249 — −15 −7948 −8990 −894 −1115 −701 −1378 −8914 −7794 202(D−4232 −4465 4158 −2649 −5412 −3676 −3575 −6036 −4125 −5722 −5419 −2993−4216 −3512 −4617 −4077 −4401 −5553 −4696 −4914 202 — −149 −500 233 43−381 399 106 −626 210 −466 −720 275 394 45 96 359 117 −369 −294 −249 —−15 −7948 −8990 −894 −1115 −701 −1378 −8914 −7788 203(M −2141 −1848−4423 −3825 −1086 −3850 −2726 2359 −3484 1059 3290 −3479 1362 −2946−3270 −2988 −2066 −538 −2251 −2080 203 — −149 −500 233 43 −381 399 106−626 210 −466 −720 275 394 45 96 359 117 −369 −294 −249 — −15 −7948−8990 −894 −1115 −701 −1378 −8914 −7781 204(P) −4497 −4117 −4899 −5251−5560 −4139 −4798 −6328 −5454 −5976 −5741 −5026 4302 −5328 −5104 −4798−4844 −5739 −4665 −5484 204 — −149 −500 233 43 −381 399 106 −626 210−466 −720 275 394 45 96 359 117 −369 −294 −249 — −15 −7948 −8990 −894−1115 −701 −1378 −8914 −7775 205(E) −2636 −4572 1810 3431 −4760 −2390−1841 −4772 −2235 −4607 −4040 −995 −2973 −1537 −3199 −2253 −2735 −4218−4733 −3691 205 — −149 −500 233 43 −381 399 106 −626 210 −466 −720 275394 45 96 359 117 −369 −294 −249 — −15 −7948 −8990 −894 −1115 −701 −1378−8914 −7768 206(I) −2944 −2476 −5069 −4784 2837 −4680 −2731 3180 −4519−584 −703 −4172 −4449 −3817 −4249 −3998 −2901 −494 −1967 −1074 206 —−149 −500 233 43 −381 399 106 −626 210 −466 −720 275 394 45 96 359 117−369 −294 −249 — −15 −7948 −8991 −894 −1115 −701 −1378 −8914 −7762207(T) −1149 −1001 −3245 −2651 −830 −2680 −1537 −200 −2295 678 −115−2252 −2729 −1967 −2187 −1772 2521 1202 −1425 1941 207 — −149 −500 23343 −381 399 106 −626 210 −466 −720 275 394 45 96 359 117 −369 −294 −249— −15 −7948 −8991 −894 −1115 −701 −1378 −8914 −7755 208(N 968 −3781 24221475 −4014 −2190 −1399 −3875 −1453 −3773 −3006 2431 −2639 −1035 −2184−1745 −2052 −3376 −3962 −3054 208 — −149 −500 233 43 −381 399 106 −626210 −466 −720 275 394 45 96 359 117 −369 −294 −249 — −15 −7948 −8991−894 −1115 −701 −1378 −8914 −7748 209(W 1214 −2627 −4165 −4274 −2248−2999 −2977 −3589 −3845 −3575 −3208 −3402 −3626 −3726 −3688 −2549 −2659−3197 5855 −1919 209 — −149 −500 233 43 −381 399 106 −626 210 −466 −720275 394 45 96 359 117 −369 −294 −249 — −15 −7948 −8991 −894 −1115 −701−1378 −8914 −7741 210(V −1358 −2495 −1397 −737 −2853 −2276 −735 −24721340 −2436 −1616 −951 1242 1587 1414 −1276 −1250 1808 −2580 −2097 210 —−149 −500 233 43 −381 399 106 −626 210 −466 −720 275 394 45 96 359 117−369 −294 −249 — −16 −7949 −8991 −894 −1115 −701 −1378 −8914 −7735 211(W−3498 −2927 −4676 −4658 236 −4377 −1183 −2501 −4186 −2296 −2147 −3324−4322 −3336 −3785 −3580 −3418 1241 5352 2614 211 — −149 −500 233 43 −381399 106 −626 210 −466 −720 275 394 45 96 359 117 −369 −294 −249 — −16−7949 −8991 −894 −1115 −701 −1378 −8914 −7728 212(H −955 −1646 −1373−926 1547 635 2162 −1632 −859 −1839 −1087 −1075 2103 −763 −1254 967 −989−1372 −2122 −1543 212 — * * * * * * * * * * * * * * * * * * * *— * * * * * * * −8914 0

TABLE 14 HMMER2.0 [2.2g] NAME PTA_PTB_exp_seqs LENG 355 ALPH Amino RF noCS no MAP yes COM /app/public/hmmer/current/bin/hmmbuild PTA_exp_hmmPTA_PTB_exp_seqs.aln COM /app/public/hmmer/current/bin/hmmcalibratePTA_exp_hmm NSEQ 10 DATE Mon Nov 30 18:53:24 2009 CKSUM 2317 XT −8455 −4−1000 −1000 −8455 −4 −8455 −4 NULT −4 −8455 NULE 595 −1558 85 338 −294453 −1158 197 249 902 −1085 −142 −21 −313 45 531 201 384 −1998 −644 EVD−321.869965 0.133020 A C D E F G H I K HMM m->m m->i m->d i->m i->i d->md->d b->m m->e L M N P Q R S T V W Y −438 * −1933  1(M) −1511 −1258−3275 −2807 2269 −2995 −1346 266 −2474 800 3792 −2446 −2858 −1968 −2335−2172 −1449 −138 −793 −87 26 — −149 −500 233 43 −381 399 106 −626 210−466 −720 275 394 45 96 359 117 −369 −294 −249 — −23 −6577 −7619 −894−1115 −701 −1378 −438 *  2(M) 426 −1446 −3780 −3363 −1521 −2856 −2514−90 −3024 −729 4481 −2828 −3133 −2721 −2939 −2091 −1564 1100 −2424 −212427 — −149 −500 233 43 −381 399 106 −626 210 −466 −720 275 394 45 96 359117 −369 −294 −249 — −10 −7762 −8804 −894 −1115 −701 −1378 * *  3(D)−898 −2223 2613 −202 −2512 −1832 −557 −2225 779 −2241 1722 −504 −1962−125 −678 389 566 −1836 −2468 −1816 28 — −149 −500 233 43 −381 399 106−626 210 −466 −720 275 394 45 96 359 117 −369 −294 −249 — −9 −7942 −8984−894 −1115 −701 −1378 * *  4(L) −3343 −2811 −5687 −5115 2061 −5345 −39111769 −4867 2527 56 −5003 −4615 −3800 −4424 −4629 −3207 −1173 −2733 −267529 — −149 −500 233 43 −381 399 106 −626 210 −466 −720 275 394 45 96 359117 −369 −294 −249 — −9 −7942 −8984 −894 −1115 −701 −1378 * *  5(F)−3039 −2583 −5400 −4800 2731 −4939 −3665 2351 −4517 1482 1999 −4610−4383 −3595 −4132 −4161 −2919 −1092 −2663 −2673 30 — −149 −500 233 43−381 399 106 −626 210 −466 −720 275 394 45 96 359 117 −369 −294 −249 —−9 −7942 −8984 −894 −1115 −701 −1378 * *  6(E) −1913 −3483 −329 3240−3847 −2201 −1343 −3669 −1205 −3580 −2799 −844 −2614 1375 −1770 328−1937 −3187 −3742 −2936 31 — −149 −500 233 43 −381 399 106 −626 210 −466−720 275 394 45 96 359 117 −369 −294 −249 — −9 −7942 −8984 −894 −1115−701 −1378 * *  7(K) −892 −2327 −754 −192 −2667 −1850 −472 −2397 1835−2332 −1421 831 −1938 1186 1037 1297 497 −1961 −2483 −1835 32 — −149−500 233 43 −381 399 106 −626 210 −466 −720 275 394 45 96 359 117 −369−294 −249 — −9 −7942 −8984 −894 −1115 −701 −1378 * *  8(I) 514 −1727−4577 −4078 −1745 −4080 −3252 2588 −3824 1712 −655 −3731 −3953 −3476−3724 −3273 −2060 1203 −2879 −2568 33 — −149 −500 233 43 −381 399 106−626 210 −466 −720 275 394 45 96 359 117 −369 −294 −249 — −9 −7942 −8984−894 −1115 −701 −1378 * *  9(W) 681 −1696 −954 −400 531 −1888 −578 3241375 −1628 −839 −651 −1974 1030 909 344 −741 −1214 2014 −1462 34 — −149−500 233 43 −381 399 106 −626 210 −466 −720 275 394 45 96 359 117 −369−294 −249 — −9 −7942 −8984 −894 −1115 −701 −1378 * *  10(E) −1665 −33131727 2676 −3578 225 −1130 −3392 −1004 −3309 −2472 −694 −2435 928 −1638306 −1659 −2915 −3488 −2672 35 — −149 −500 233 43 −381 399 106 −626 210−466 −720 275 394 45 96 359 117 −369 −294 −249 — −9 −7942 −8984 −894−1115 −701 −1378 * *  11(K) −1580 1884 −1764 −1020 −2907 −2481 −845−2479 1956 772 −1679 −1179 −2514 1923 1777 −1525 −1447 −2203 −2604 −219736 — −149 −500 233 43 −381 399 106 −626 210 −466 −720 275 394 45 96 359117 −369 −294 −249 — −9 −7942 −8984 −894 −1115 −701 −1378 * *  12(A)2315 −1624 −4424 −3936 −1894 −3936 −3165 1771 −3688 61 −834 −3585 −3870−3418 −3634 −3127 −1946 1865 −2913 −2538 37 — −149 −500 233 43 −381 399106 −626 210 −466 −720 275 394 45 96 359 117 −369 −294 −249 — −9 −7942−8984 −894 −1115 −701 −1378 * *  13(K) 240 −2148 −1205 −600 −2451 −2088−695 −2066 2741 −2143 −1331 −829 −2179 −293 688 −1066 326 519 −2394−1872 38 — −149 −500 233 43 −381 399 106 −626 210 −466 −720 275 394 4596 359 117 −369 −294 −249 — −9 −7942 −8984 −894 −1115 −701 −1378 * * 14(Q) 251 −2245 585 −74 −2564 1048 −408 −2314 875 −2260 −1335 −384 5151120 955 394 −715 −1866 −2429 −1747 39 — −149 −500 233 43 −381 399 106−626 210 −466 −720 275 394 45 96 359 117 −369 −294 −249 — −9 −7942 −8984−894 −1115 −701 −1378 * *  15(D) 511 −2241 1741 −132 −2549 −1792 −445−2281 1286 455 −1337 −435 −1886 971 685 −711 −760 −1857 −2426 −1765 40 —−149 −500 233 43 −381 399 106 −626 210 −466 −720 275 394 45 96 359 117−369 −294 −249 — −9 −7942 −8984 −894 −1115 −701 −1378 * *  16(K) −884−2341 1633 −125 −2653 223 −507 −2400 1752 −2356 −1445 919 707 −57 −629−761 −829 80 −2535 −1850 41 — −149 −500 233 43 −381 399 106 −626 210−466 −720 275 394 45 96 359 117 −369 −294 −249 — −9 −7942 −8984 −894−1115 −701 −1378 * *  17(K) 535 −1741 −1193 −620 −1889 −2043 −709 3272612 −1654 −903 −840 −2126 854 −679 −1007 −888 295 −2069 −1566 42 — −149−500 233 43 −381 399 106 −626 210 −466 −720 275 394 45 96 359 117 −369−294 −249 — −9 −7942 −8984 −894 −1115 −701 −1378 * *  18(K) −2416 −3238−2867 −1785 −4015 −3059 −1120 −3414 2580 −3139 −2429 −1764 −3047 −6982089 −2312 2234 −3140 −3041 −2859 43 — −149 −500 233 43 −381 399 106−626 210 −466 −720 275 394 45 96 359 117 −369 −294 −249 — −9 −7942 −8984−894 −1115 −701 −1378 * *  19(I) −2521 −2024 −5153 −4783 −2223 −4929−4595 3447 −4687 294 −972 −4589 −4629 −4430 −4724 −4267 −2498 1528 −3873−3540 44 — −149 −500 233 43 −381 399 106 −626 210 −466 −720 275 394 4596 359 117 −369 −294 −249 — −9 −7942 −8984 −894 −1115 −701 −1378 * * 20(V) 213 −1847 −4873 −4520 −2465 −4420 −4247 1419 −4388 −1381 −1247−4198 −4362 −4252 −4452 −3727 −2270 3336 −3880 −3419 45 — −149 −500 23343 −381 399 106 −626 210 −466 −720 275 394 45 96 359 117 −369 −294 −249— −9 −7942 −8984 −894 −1115 −701 −1378 * *  21(F) −3693 −3087 −5586−5265 3261 −5304 −2888 −912 −4973 2381 −226 −4694 −4708 −3838 −4472−4669 −3558 −1678 −1934 −1153 46 — −149 −500 233 43 −381 399 106 −626210 −466 −720 275 394 45 96 359 117 −369 −294 −249 — −9 −7942 −8984 −894−1115 −701 −1378 * *  22(P) 1357 −1977 −3526 −3796 −4305 −2211 −3504−4098 −3878 −4361 −3542 −2788 3823 −3529 −3749 −1636 −1847 −3043 −4411−4353 47 — −149 −500 233 43 −381 399 106 −626 210 −466 −720 275 394 4596 359 117 −369 −294 −249 — −9 −7942 −8984 −894 −1115 −701 −1378 * * 23(E) −2645 −4564 1495 3508 −4762 −2401 −1853 −4778 −2245 −4613 −4046−1009 −2982 −1550 −3202 −2265 −2745 −4225 −4728 −3699 48 — −149 −500 23343 −381 399 106 −626 210 −466 −720 275 394 45 96 359 117 −369 −294 −249— −9 −7942 −8984 −894 −1115 −701 −1378 * *  24(G) 828 −1562 −2312 −1921−2620 2562 −1856 −2263 −1813 −2508 −1731 −1730 −2452 −1660 −2098 554 782−1818 −2902 1503 49 — −149 −500 233 43 −381 399 106 −626 210 −466 −720275 394 45 96 359 117 −369 −294 −249 — −9 −7942 −8984 −894 −1115 −701−1378 * *  25(E) −1027 −2214 −837 2256 −2461 −1966 −641 −2117 974 634−1343 −652 −2082 −229 −588 −955 1152 −1790 −2438 −1847 50 — −149 −500233 43 −381 399 106 −626 210 −466 −720 275 394 45 96 359 117 −369 −294−249 — −9 −7942 −8984 −894 −1115 −701 −1378 * *  26(W) −150 757 49 299−277 −651 839 −485 392 −910 599 300 −401 623 162 −99 38 −448 1107 126 51— −149 −500 233 43 −381 399 106 −626 210 −466 −720 275 394 45 96 359 117−369 −294 −249 — −9 −7942 −8984 −894 −1115 −701 −1378 * *  27(D) −2650−4626 3535 2005 −4794 −2383 −1844 −4814 −2264 −4643 −4090 −983 −2972−1542 −3255 −2259 −2754 −4254 −4780 −3711 52 — −149 −500 233 43 −381 399106 −626 210 −466 −720 275 394 45 96 359 117 −369 −294 −249 — −9 −7942−8984 −894 −1115 −701 −1378 * *  28(E) −884 −1962 −861 2360 −2149 −1901−576 272 764 −268 −1086 −611 909 −182 −632 −849 −822 −1489 −2226 −164853 — −149 −500 233 43 −381 399 106 −626 210 −466 −720 275 394 45 96 359117 −369 −294 −249 — −9 −7942 −8984 −894 −1115 −701 −1378 * *  29(R)−4488 −4181 −4789 −4318 −5193 −4148 −3436 −5568 −2393 −5152 −4748 −4156−4479 −3286 4202 −4614 −4467 −5273 −4267 −4649 54 — −149 −500 233 43−381 399 106 −626 210 −466 −720 275 394 45 96 359 117 −369 −294 −249 —−9 −7942 −8984 −894 −1115 −701 −1378 * *  30(V) −1615 −1406 −3692 −3190−1680 −3315 −2460 2105 −2933 −1136 −730 1527 −3366 −2700 −2939 −2463 5762489 −2439 −2054 55 — −149 −500 233 43 −381 399 106 −626 210 −466 −720275 394 45 96 359 117 −369 −294 −249 — −9 −7942 −8984 −894 −1115 −701−1378 * *  31(L) −2893 −2389 −5409 −4931 −1519 −5116 −4253 2238 −47532516 −300 −4794 −4601 −4030 −4524 −4423 −2823 819 −3207 −3187 56 — −149−500 233 43 −381 399 106 −626 210 −466 −720 275 394 45 96 359 117 −369−294 −249 — −9 −7942 −8984 −894 −1115 −701 −1378 * *  32(K) −810 −2256−666 736 −2577 491 −428 19 1965 −2266 −1348 −419 −1872 1176 702 323 −747−1879 −2434 −1767 57 — −149 −500 233 43 −381 399 106 −626 210 −466 −720275 394 45 96 359 117 −369 −294 −249 — −9 −7942 −8984 −894 −1115 −701−1378 * *  33(A) 3609 −2508 −4184 −4493 −4592 −2737 −3989 −4421 −4496−4701 −4051 −3440 −3474 −4171 −4253 −2294 −2487 −3536 −4484 −4643 58 —−149 −500 233 43 −381 399 106 −626 210 −466 −720 275 394 45 96 359 117−369 −294 −249 — −9 −7942 −8984 −894 −1115 −701 −1378 * *  34(A) 2937−1528 −3502 −3308 −3125 −1952 −2769 −2630 −3081 −3039 −2271 −2390 −2643−2779 −3078 549 1011 493 −3475 −3206 59 — −149 −500 233 43 −381 399 106−626 210 −466 −720 275 394 45 96 359 117 −369 −294 −249 — −9 −7942 −8984−894 −1115 −701 −1378 * *  35(H) 804 −2234 624 1374 −2527 −1779 1863−180 −65 −2239 −1335 −424 −1886 −14 −572 1383 −764 −1842 −2435 −1765 60— −149 −500 233 43 −381 399 106 −626 210 −466 −720 275 394 45 96 359 117−369 −294 −249 — −9 −7942 −8984 −894 −1115 −701 −1378 * *  36(K) −927−1951 −1003 613 −2143 −1960 −589 446 1801 −1893 1449 −680 −2039 −2011687 −903 −856 −1504 −2198 1303 61 — −149 −500 233 43 −381 399 106 −626210 −466 −720 275 394 45 96 359 117 −369 −294 −249 — −9 −7942 −8984 −894−1115 −701 −1378 * *  37(I) −3179 −2647 −5611 −5124 −1356 −5341 −43172901 −4907 2264 −148 −5052 −4698 −4019 −4582 −4697 −3088 −546 −3099−3137 62 — −149 −500 233 43 −381 399 106 −626 210 −466 −720 275 394 4596 359 117 −369 −294 −249 — −9 −7942 −8984 −894 −1115 −701 −1378 * * 38(I) 1305 −916 −2346 −1758 −894 −2325 −1140 1372 98 911 −104 −1638−2383 1135 −1607 −1364 −839 747 −1366 −994 63 — −149 −500 233 43 −381399 106 −626 210 −466 −720 275 394 45 96 359 117 −369 −294 −249 — −9−7942 −8984 −894 −1115 −701 −1378 * *  39(K) 103 −2280 −655 781 −2607−33 −431 −2352 2090 −2292 −1371 817 −1875 1393 703 −697 −754 −1906 −2454−1782 64 — −149 −500 233 43 −381 399 106 −626 210 −466 −720 275 394 4596 359 117 −369 −294 −249 — −9 −7942 −8984 −894 −1115 −701 −1378 * * 40(D) −876 −2355 1990 1398 −2673 −1797 −489 −2425 861 −2368 −1450 862−1916 −35 739 −749 −818 −1976 −2535 1245 65 — −149 −500 233 43 −381 399106 −626 210 −466 −720 275 394 45 96 359 117 −369 −294 −249 — −9 −7942−8984 −894 −1115 −701 −1378 * *  41(G) −1910 −3521 1036 −459 −3833 2939−1305 −3641 669 −3546 −2760 −819 −2598 922 −1710 −1672 −1918 −3170 −3710−2907 66 — −149 −500 233 43 −381 399 106 −626 210 −466 −720 275 394 4596 359 117 −369 −294 −249 — −9 −7942 −8984 −894 −1115 −701 −1378 * * 42(L) −2752 −2316 −5181 −4626 1316 −4723 −3629 2215 −4364 2228 −104−4388 −4302 −3622 −4077 −3942 −2665 822 −2775 −2716 67 — −149 −500 23343 −381 399 106 −626 210 −466 −720 275 394 45 96 359 117 −369 −294 −249— −9 −7942 −8984 −894 −1115 −701 −1378 * *  43(A) 2595 −1592 −4065 −3655−1874 −3190 −2875 69 −3364 237 −870 −3140 −3438 −3084 −3305 −2430 −17712003 −2788 −2442 68 — −149 −500 233 43 −381 399 106 −626 210 −466 −720275 394 45 96 359 117 −369 −294 −249 — −9 −7942 −8984 −894 −1115 −701−1378 * *  44(K) −781 −2248 1290 1182 −2566 −1751 −412 −18 1303 −2262−1338 836 −1846 47 956 −662 674 −1869 −2432 −1751 69 — −149 −500 233 43−381 399 106 −626 210 −466 −720 275 394 45 96 359 117 −369 −294 −249 —−9 −7942 −8984 −894 −1115 −701 −1378 * *  45(P) −1999 −1685 −4334 −3818−1612 −3852 −2976 1828 −3535 394 −557 −3486 3050 −3199 −3450 −3026 −19641176 −2676 −2369 70 — −149 −500 233 43 −381 399 106 −626 210 −466 −720275 394 45 96 359 117 −369 −294 −249 — −9 −7942 −8984 −894 −1115 −701−1378 * *  46(V) −2452 −1958 −5119 −4802 −2578 −4903 −4884 2288 −4745−1352 −1293 −4595 −4680 −4675 −4887 −4275 −2449 3237 −4279 −3776 71 —−149 −500 233 43 −381 399 106 −626 210 −466 −720 275 394 45 96 359 117−369 −294 −249 — −9 −7942 −8984 −894 −1115 −701 −1378 * *  47(L) −2998−2538 −5403 −4947 −1395 −4989 −4115 −173 −4693 2765 −209 −4769 −4551−3928 −4414 −4328 −2940 1827 −3062 −3033 72 — −149 −500 233 43 −381 399106 −626 210 −466 −720 275 394 45 96 359 117 −369 −294 −249 — −9 −7942−8984 −894 −1115 −701 −1378 * *  48(V) −2510 −2021 −5126 −4737 −2130−4872 −4437 1947 −4622 1286 −893 −4529 −4574 −4319 −4624 −4190 −24832866 −3732 −3431 73 — −149 −500 233 43 −381 399 106 −626 210 −466 −720275 394 45 96 359 117 −369 −294 −249 — −9 −7942 −8984 −894 −1115 −701−1378 * *  49(G) 931 −1908 −3564 −3879 −4400 3463 −3561 −4237 −4052−4490 −3601 −2764 −2927 −3600 −3877 −1557 −1777 −3055 −4501 −4478 74 —−149 −500 233 43 −381 399 106 −626 210 −466 −720 275 394 45 96 359 117−369 −294 −249 — −9 −7942 −8984 −894 −1115 −701 −1378 * *  50(N) 91−2861 975 −587 −3637 −2069 −1361 −3439 −1272 −3412 −2579 2972 −2496 −985−1877 1896 −1654 −2876 −3606 −2851 75 — −149 −500 233 43 −381 399 106−626 210 −466 −720 275 394 45 96 359 117 −369 −294 −249 — −9 −7942 −8984−894 −1115 −701 −1378 * *  51(E) −1387 −2840 −463 2722 −3195 −2028 −944−2952 −645 −2907 −2050 −684 1763 936 −1162 −1231 313 −2508 −3091 −237776 — −149 −500 233 43 −381 399 106 −626 210 −466 −720 275 394 45 96 359117 −369 −294 −249 — −9 −7942 −8984 −894 −1115 −701 −1378 * *  52(N)1378 −2248 457 624 806 −1762 −434 −2299 865 −2258 −1342 1494 −1863 20−534 341 −740 −1863 −2438 −1760 77 — −149 −500 233 43 −381 399 106 −626210 −466 −720 275 394 45 96 359 117 −369 −294 −249 — −9 −7942 −8984 −894−1115 −701 −1378 * *  53(E) 975 −2349 734 2085 −2655 −1807 −516 −23991272 −2359 −1451 −445 −1934 −67 −640 −772 −840 10 −2541 −1856 78 — −149−500 233 43 −381 399 106 −626 210 −466 −720 275 394 45 96 359 117 −369−294 −249 — −9 −7942 −8984 −894 −1115 −701 −1378 * *  54(I) −2526 −2030−5153 −4776 −2181 −4921 −4549 3338 −4675 616 −934 −4580 −4616 −4394−4697 −4253 −2501 1644 −3821 −3507 79 — −149 −500 233 43 −381 399 106−626 210 −466 −720 275 394 45 96 359 117 −369 −294 −249 — −9 −7942 −8984−894 −1115 −701 −1378 * *  55(K) 398 −2606 −1173 479 −3022 −2165 −660−2692 2540 −2573 −1705 −805 −2232 1750 1236 −1146 −1168 −2286 −2659−2117 80 — −149 −500 233 43 −381 399 106 −626 210 −466 −720 275 394 4596 359 117 −369 −294 −249 — −9 −7942 −8984 −894 −1115 −701 −1378 * * 56(E) 1257 −2318 −622 1753 −2641 −1799 −475 −2386 1275 −2333 −1417 −437−1908 1398 −542 391 −801 −1943 −2501 −1824 81 — −149 −500 233 43 −381399 106 −626 210 −466 −720 275 394 45 96 359 117 −369 −294 −249 — −9−7942 −8984 −894 −1115 −701 −1378 * *  57(F) 471 −982 −1994 −1417 1160−2213 −1003 −523 1101 784 −172 584 −2279 −1043 −1416 −1230 532 1019−1408 −1017 82 — −149 −500 233 43 −381 399 106 −626 210 −466 −720 275394 45 96 359 117 −369 −294 −249 — −9 −7942 −8984 −894 −1115 −701−1378 * *  58(A) 3609 −2508 −4184 −4493 −4592 −2737 −3989 −4421 −4496−4701 −4051 −3440 −3474 −4171 −4253 −2294 −2487 −3536 −4484 −4643 83 —−149 −500 233 43 −381 399 106 −626 210 −466 −720 275 394 45 96 359 117−369 −294 −249 — −9 −7942 −8984 −894 −1115 −701 −1378 * *  59(K) 252−2225 594 −101 −2531 1206 −438 −2270 1451 −150 −1326 673 −1865 14 −536340 −739 −1841 −2425 −1752 84 — −149 −500 233 43 −381 399 106 −626 210−466 −720 275 394 45 96 359 117 −369 −294 −249 — −299 −7942 −2449 −894−1115 −701 −1378 * *  60(E) 1167 −2286 732 1831 −2598 −1667 −407 −2354951 −2301 −1391 −300 −1816 40 −560 783 −749 −1906 −2475 −1775 85 — −149−500 233 43 −381 399 106 −626 210 −466 −720 275 394 45 96 359 117 −369−294 −249 — −11 −7654 −8696 −894 −1115 −1585 −585 * *  61(H) −815 −727−2621 −2031 1145 −2289 2094 −200 −1722 1681 107 494 −2340 −1435 −1697−1354 −755 1054 −1030 −564 86 — −149 −500 233 43 −381 399 106 −626 210−466 −720 275 394 45 96 359 117 −369 −294 −249 — −11 −7654 −8696 −894−1115 −337 −2262 * *  62(N) −1704 −3281 1777 −397 −3622 1646 −1188 −3429−1036 −3352 −2526 2598 −2480 −796 1047 −1495 −1710 −2949 −3526 −2731 87— −149 −500 233 43 −381 399 106 −626 210 −466 −720 275 394 45 96 359 117−369 −294 −249 — −9 −7942 −8984 −894 −1115 −701 −1378 * *  63(M) 20−1214 −3805 −3190 774 −3078 −1973 1042 −2815 1458 2157 −2723 −3056 −2395−2615 −2183 −1382 1944 −1731 −1436 88 — −149 −500 233 43 −381 399 106−626 210 −466 −720 275 394 45 96 359 117 −369 −294 −249 — −9 −7942 −8984−894 −1115 −701 −1378 * *  64(D) 605 −2467 2563 −401 −3040 −1918 −912−2798 −624 −2777 −1892 929 −2187 −492 −1157 1186 553 −2307 −2970 −227989 — −149 −500 233 43 −381 399 106 −626 210 −466 −720 275 394 45 96 359117 −369 −294 −249 — −9 −7942 −8984 −894 −1115 −701 −1378 * *  65(L)−3447 −2885 −5829 −5243 −1145 −5544 −4253 1795 −5014 2666 2377 −5248−4707 −3887 −4549 −4864 −3303 −1162 −2916 −3088 90 — −149 −500 233 43−381 399 106 −626 210 −466 −720 275 394 45 96 359 117 −369 −294 −249 —−9 −7942 −8984 −894 −1115 −701 −1378 * *  66(D) 250 −2410 1559 1458−2748 39 −576 −2502 −207 −2454 −1544 −475 −1976 −130 −729 1014 986 −2052−2631 −1936 91 — −149 −500 233 43 −381 399 106 −626 210 −466 −720 275394 45 96 359 117 −369 −294 −249 — −9 −7942 −8984 −894 −1115 −701−1378 * *  67(G) −2653 −3216 −2503 −2570 −4722 3367 −2672 −4647 1672−4521 −3864 −2587 −3560 −2414 −2013 −2728 −2874 −3999 −4152 −4117 92 —−149 −500 233 43 −381 399 106 −626 210 −466 −720 275 394 45 96 359 117−369 −294 −249 — −9 −7942 −8984 −894 −1115 −701 −1378 * *  68(V) 1628−1694 −4600 −4141 −2065 −4161 −3476 2051 −3925 24 −959 −3809 −4058 −3687−3896 −3377 −2060 2431 −3181 −2784 93 — −149 −500 233 43 −381 399 106−626 210 −466 −720 275 394 45 96 359 117 −369 −294 −249 — −9 −7942 −8984−894 −1115 −701 −1378 * *  69(Q) −1107 −2491 −869 2104 −2843 −2005 −610−2548 1501 −2474 1449 −645 −2106 2280 −390 −986 −1031 −2135 −2613 −200494 — −149 −500 233 43 −381 399 106 −626 210 −466 −720 275 394 45 96 359117 −369 −294 −249 — −9 −7942 −8984 −894 −1115 −701 −1378 * *  70(I)−2462 −1971 −5120 −4803 −2532 −4890 −4848 3484 −4737 −1301 −1256 −4591−4671 −4645 −4865 −4262 −2459 1950 −4227 −3745 95 — −149 −500 233 43−381 399 106 −626 210 −466 −720 275 394 45 96 359 117 −369 −294 −249 —−9 −7942 −8984 −894 −1115 −701 −1378 * *  71(V) −1021 −845 −3291 115−783 −2586 −1463 1772 −2289 711 1731 −2204 −2623 −1926 −2122 −1672 −9631810 −1336 1149 96 — −149 −500 233 43 −381 399 106 −626 210 −466 −720275 394 45 96 359 117 −369 −294 −249 — −9 −7942 −8984 −894 −1115 −701−1378 * *  72(D) −4232 −4465 4158 −2649 −5412 −3676 −3575 −6036 −4125−5722 −5419 −2993 −4216 −3512 −4617 −4077 −4401 −5553 −4696 −4914 97 —−149 −500 233 43 −381 399 106 −626 210 −466 −720 275 394 45 96 359 117−369 −294 −249 — −9 −7942 −8984 −894 −1115 −701 −1378 * *  73(P) −1143−1675 −3005 −2989 −3065 −2064 −2700 565 −2869 −2950 −2300 −2338 3698−2683 −2908 587 −1504 −2001 −3467 −3104 98 — −149 −500 233 43 −381 399106 −626 210 −466 −720 275 394 45 96 359 117 −369 −294 −249 — −9 −7942−8984 −894 −1115 −701 −1378 * *  74(H) 1253 −2202 −717 1654 −2478 −18382550 −2187 868 −372 −1310 −496 −1938 −63 −532 −776 −809 −1802 −2405−1767 99 — −149 −500 233 43 −381 399 106 −626 210 −466 −720 275 394 4596 359 117 −369 −294 −249 — −9 −7942 −8984 −894 −1115 −701 −1378 * * 75(T) −1143 −1868 −2054 −2081 −3765 −1965 −2374 −3533 −2354 −3699 −28342518 −2626 −2132 −2643 882 2968 −2663 −3905 −3493 100 — −149 −500 233 43−381 399 106 −626 210 −466 −720 275 394 45 96 359 117 −369 −294 −249 —−9 −7942 −8984 −894 −1115 −701 −1378 * *  76(Y) −1148 −1566 −1831 −1449−1231 −2241 −1207 −1418 −1361 −1676 −1002 1156 −2489 −1227 −1649 1580−1191 429 −1711 3317 101 — −149 −500 233 43 −381 399 106 −626 210 −466−720 275 394 45 96 359 117 −369 −294 −249 — −9 −7942 −8984 −894 −1115−701 −1378 * *  77(W) −150 757 49 299 −277 −651 839 −485 392 −910 599300 −401 623 162 −99 38 −448 1107 126 102 — −149 −500 233 43 −381 399106 −626 210 −466 −720 275 394 45 96 359 117 −369 −294 −249 — −9 −7942−8984 −894 −1115 −701 −1378 * *  78(E) −1130 −2548 993 1837 −2823 −1914−731 −2562 −425 645 −1679 −557 1649 −306 −961 330 −1088 −2151 −2765−2070 103 — −149 −500 233 43 −381 399 106 −626 210 −466 −720 275 394 4596 359 117 −369 −294 −249 — −9 −7942 −8984 −894 −1115 −701 −1378 * * 79(K) 705 −2293 −914 −357 −2734 819 −598 −2445 2189 −2399 −1507 −628−2037 −153 975 617 −923 −2013 −2558 −1945 104 — −149 −500 233 43 −381399 106 −626 210 −466 −720 275 394 45 96 359 117 −369 −294 −249 — −1567−7942 −603 −894 −1115 −701 −1378 * *  80(E) −1455 −2350 50 3362 −2809−1547 −927 −2700 −845 −2735 −2178 −487 −2000 −660 −1278 −1311 −1525−2365 −2625 −2220 105 — −149 −500 233 43 −381 399 106 −626 210 −466 −720275 394 45 96 359 117 −369 −294 −249 — −26 −6400 −7442 −894 −1115 −1808−485 * *  81(M) −551 −928 1713 −589 −942 −1741 −615 5 −559 −521 2643−741 −1867 −429 −905 −804 −519 1266 −1450 −997 106 — −149 −500 233 43−381 399 106 −626 210 −466 −720 275 394 45 96 359 117 −369 −294 −249 —−19 −6823 −7865 −894 −1115 −167 −3194 * *  82(K) −936 −1587 −1304 −718−1678 −2068 −727 −1273 1622 −91 1465 −909 −2141 −440 1553 −1037 1209−1083 −1910 1220 107 — −149 −500 233 43 −381 399 106 −626 210 −466 −720275 394 45 96 359 117 −369 −294 −249 — −9 −7942 −8984 −894 −1115 −701−1378 * *  83(Q) 216 −3288 1080 1963 −3557 −2088 −1124 −3366 −985 −3287−2450 −697 −2432 3156 −1608 −1439 −1648 −2893 −3467 −2658 108 — −149−500 233 43 −381 399 106 −626 210 −466 −720 275 394 45 96 359 117 −369−294 −249 — −9 −7942 −8984 −894 −1115 −701 −1378 * *  84(E) 661 −22681307 1400 −2586 −40 −425 −2337 −12 −2283 −1359 −392 −1857 1107 956 −675492 −1889 −2452 −1768 109 — −149 −500 233 43 −381 399 106 −626 210 −466−720 275 394 45 96 359 117 −369 −294 −249 — −9 −7942 −8984 −894 −1115−701 −1378 * *  85(M) −2903 −2473 −4675 −4372 1750 −4229 −1624 −1350−3989 445 3626 −3447 −4067 −3192 −3628 −3390 −2808 −1716 −937 3375 110 —−149 −500 233 43 −381 399 106 −626 210 −466 −720 275 394 45 96 359 117−369 −294 −249 — −9 −7942 −8984 −894 −1115 −701 −1378 * *  86(A) 1901−908 −3172 −2568 −899 −2621 1244 994 −2224 146 −105 −2185 −2665 −1906−2124 −1705 −1008 1900 −1447 −1095 111 — −149 −500 233 43 −381 399 106−626 210 −466 −720 275 394 45 96 359 117 −369 −294 −249 — −9 −7942 −8984−894 −1115 −701 −1378 * *  87(Q) −1463 −3014 2011 −328 −3316 −2053 −949−3092 −641 −3010 −2150 2270 −2319 2525 696 −1279 −1430 −2636 −3169 −2433112 — −149 −500 233 43 −381 399 106 −626 210 −466 −720 275 394 45 96 359117 −369 −294 −249 — −9 −7942 −8984 −894 −1115 −701 −1378 * *  88(A)2248 −2123 670 −520 −2701 −1892 −856 −2400 −496 −2451 −1589 −769 −2126−446 1017 −948 1463 −1971 −2692 −2080 113 — −149 −500 233 43 −381 399106 −626 210 −466 −720 275 394 45 96 359 117 −369 −294 −249 — −9 −7942−8984 −894 −1115 −701 −1378 * *  89(F) −2727 −2338 −4825 −4352 3286−4296 −2265 816 −3996 1550 −226 −3736 −4033 −3222 −3652 −3458 −2628−1306 3005 −774 114 — −149 −500 233 43 −381 399 106 −626 210 −466 −720275 394 45 96 359 117 −369 −294 −249 — −9 −7942 −8984 −894 −1115 −701−1378 * *  90(Y) −2126 −1823 −4287 −3802 −723 −3742 −2094 −327 −34301159 −480 −3251 −3663 −2945 −3227 −2891 −2068 2283 −1586 3201 115 — −149−500 233 43 −381 399 106 −626 210 −466 −720 275 394 45 96 359 117 −369−294 −249 — −9 −7942 −8984 −894 −1115 −701 −1378 * *  91(E) 703 −3188−772 3501 −4265 −2379 −2017 −4040 −2108 −4114 −3438 −1356 −2948 −1721−2684 −2006 −2303 −3449 −4241 −3565 116 — −149 −500 233 43 −381 399 106−626 210 −466 −720 275 394 45 96 359 117 −369 −294 −249 — −9 −7942 −8984−894 −1115 −701 −1378 * *  92(R) −2413 −2234 −4171 −3369 −1308 −3884−2460 877 −2018 2018 −224 −3190 −3714 −2356 2764 −3076 −2310 −961 −2462−2283 117 — −149 −500 233 43 −381 399 106 −626 210 −466 −720 275 394 4596 359 117 −369 −294 −249 — −9 −7942 −8984 −894 −1115 −701 −1378 * * 93(R) 738 −2612 −3347 −2738 −4144 −2736 −2052 −3768 −900 −3705 −3029−2409 −3189 −1725 3817 −2171 −2228 −3209 −3627 −3498 118 — −149 −500 23343 −381 399 106 −626 210 −466 −720 275 394 45 96 359 117 −369 −294 −249— −9 −7942 −8984 −894 −1115 −701 −1378 * *  94(K) 503 −2445 −1015 −703−3184 562 −1018 −2893 2978 −2852 −1992 704 −2331 −602 −835 −1206 −1297−2406 −2999 −2416 119 — −149 −500 233 43 −381 399 106 −626 210 −466 −720275 394 45 96 359 117 −369 −294 −249 — −9 −7942 −8984 −894 −1115 −701−1378 * *  95(H) −928 −2405 −563 997 −2720 1543 2401 −2472 959 −2417−1504 868 −1955 −84 −643 392 −872 −2026 −2586 −1897 120 — −149 −500 23343 −381 399 106 −626 210 −466 −720 275 394 45 96 359 117 −369 −294 −249— −9 −7942 −8984 −894 −1115 −701 −1378 * *  96(K) −4125 −4091 −4017−3615 −5101 −3960 −2958 −5182 3972 −4825 −4345 −3552 −4249 −2709 −1809−4154 −4044 −4895 −4132 −4389 121 — −149 −500 233 43 −381 399 106 −626210 −466 −720 275 394 45 96 359 117 −369 −294 −249 — −809 −7942 −1234−894 −1115 −701 −1378 * *  97(G) −2666 −2751 −3377 −3700 −4393 3753−3528 −4841 −4031 −4741 −4286 −3394 −3411 −3824 −3848 −2912 −3053 −4080−3719 −4290 122 — −149 −500 233 43 −381 399 106 −626 210 −466 −720 275394 45 96 359 117 −369 −294 −249 — −15 −7148 −8190 −894 −1115 −541−1677 * *  98(M) 412 −754 −2560 −1966 −741 −2291 −1150 981 −1684 −5983179 1245 −2352 −1421 −1700 −1351 649 877 −1235 −874 123 — −149 −500 23343 −381 399 106 −626 210 −466 −720 275 394 45 96 359 117 −369 −294 −249— −10 −7762 −8804 −894 −1115 −413 −2007 * *  99(T) −2430 −2823 −4179−4462 −4591 −3027 −4037 −4454 −4406 −4707 −4191 −3664 −3724 −4237 −4215−2689 4010 −3747 −4431 −4588 124 — −149 −500 233 43 −381 399 106 −626210 −466 −720 275 394 45 96 359 117 −369 −294 −249 — −9 −7942 −8984 −894−1115 −701 −1378 * * 100(P) 270 −1065 −2103 243 −1059 −2317 −1151 1403−1372 790 −240 −1539 2257 −1198 −1557 −1358 −904 −375 −1531 −1145 125 —−149 −500 233 43 −381 399 106 −626 210 −466 −720 275 394 45 96 359 117−369 −294 −249 — −9 −7942 −8984 −894 −1115 −701 −1378 * * 101(E) −2392−4275 1163 3312 −4486 −2295 −1667 −4423 −1934 −4288 −3633 −894 1125−1341 −2802 −2049 −2468 −3888 −4470 −3454 126 — −149 −500 233 43 −381399 106 −626 210 −466 −720 275 394 45 96 359 117 −369 −294 −249 — −9−7942 −8984 −894 −1115 −701 −1378 * * 102(Q 297 −2471 1012 −160 −2788−1849 −577 −2543 1870 −2482 −1573 944 −1994 2462 −693 −848 −930 −2093−2649 −1955 127 — −149 −500 233 43 −381 399 106 −626 210 −466 −720 275394 45 96 359 117 −369 −294 −249 — −9 −7942 −8984 −894 −1115 −701−1378 * * 103(A 3227 −1594 −3807 −3849 −3646 −1945 −3198 −3067 −3621−3576 −2783 −2572 −2704 −3241 −3481 576 −1455 241 −3977 −3779 128 — −149−500 233 43 −381 399 106 −626 210 −466 −720 275 394 45 96 359 117 −369−294 −249 — −9 −7942 −8984 −894 −1115 −701 −1378 * * 104(D 1261 −22671791 738 −2557 −1813 −517 −2280 −130 −2273 −1380 −464 −1934 −76 1383−771 −825 386 −2479 −1813 129 — −149 −500 233 43 −381 399 106 −626 210−466 −720 275 394 45 96 359 117 −369 −294 −249 — −9 −7942 −8984 −894−1115 −701 −1378 * * 105(K 415 −2546 −735 1917 −2896 −1973 −635 −26212122 −2543 −1653 −608 −2101 1705 −517 −981 −1047 −2189 −2683 −2042 130 —−149 −500 233 43 −381 399 106 −626 210 −466 −720 275 394 45 96 359 117−369 −294 −249 — −9 −7942 −8984 −894 −1115 −701 −1378 * * 106(M 308 −827−2563 −1964 −795 −2335 −1167 1419 607 −677 2765 −1747 −2393 −1425 −1700−1388 1409 −241 2166 −912 131 — −149 −500 233 43 −381 399 106 −626 210−466 −720 275 394 45 96 359 117 −369 −294 −249 — −9 −7942 −8984 −894−1115 −701 −1378 * * 107(M −2838 −2385 −5273 −4720 −1280 −4846 −37691119 −4469 2241 2938 −4517 −4377 −3690 −4172 −4080 −2748 1487 −2847−2840 132 — −149 −500 233 43 −381 399 106 −626 210 −466 −720 275 394 4596 359 117 −369 −294 −249 — −9 −7942 −8984 −894 −1115 −701 −1378 * *108(K −1031 −2407 −918 1080 −2761 −1972 −550 −2464 1949 −434 −1505 −616−2053 −100 1475 1180 −952 −2050 −2533 −1929 133 — −149 −500 233 43 −381400 106 −626 210 −466 −720 275 394 45 96 359 117 −369 −294 −249 — −169−3204 −8984 −206 −2913 −701 −1378 * * 109(D −4232 −4465 4158 −2649 −5412−3676 −3575 −6036 −4125 −5722 −5419 −2993 −4216 −3512 −4617 −4077 −4401−5553 −4696 −4914 135 — −149 −500 233 43 −381 399 106 −626 210 −466 −720275 394 45 96 359 117 −369 −294 −249 — −9 −7942 −8984 −894 −1115 −701−1378 * * 110(P) −893 2081 −1781 940 −1121 −2183 −978 444 −1070 −1013−334 −1295 2567 −933 −1326 −1202 −842 −568 −1538 1138 136 — −149 −500233 43 −381 399 106 −626 210 −466 −720 275 394 45 96 359 117 −369 −294−249 — −9 −7942 −8984 −894 −1115 −701 −1378 * * 111(N −1006 −916 −2854−2266 −891 −2503 −1385 865 −1966 1747 −97 1859 −2563 −1688 −1947 −70−954 854 −1419 −1063 137 — −149 −500 233 43 −381 399 106 −626 210 −466−720 275 394 45 96 359 117 −369 −294 −249 — −9 −7942 −8984 −894 −1115−701 −1378 * * 112(Y −4083 −3282 −4926 −5082 1832 −4728 −1188 −2828−4652 −2243 2245 −3495 −4595 −3549 −4122 −3951 −3965 −3052 −449 4351 138— −149 −500 233 43 −381 399 106 −626 210 −466 −720 275 394 45 96 359 117−369 −294 −249 — −9 −7942 −8984 −894 −1115 −701 −1378 * * 113(F) −4576−3559 −5015 −5343 4263 −4881 −1152 −3449 −4910 −2776 −2865 −3550 −4757−3679 −4300 −4154 −4444 −3622 −401 2124 139 — −149 −500 233 43 −381 399106 −626 210 −466 −720 275 394 45 96 359 117 −369 −294 −249 — −9 −7942−8984 −894 −1115 −701 −1378 * * 114(G 2612 −1827 −3654 −3943 −4336 2661−3533 −4149 −4027 −4411 −3508 −2727 −2864 −3570 −3838 −1474 −1691 −2967−4475 −4432 140 — −149 −500 233 43 −381 399 106 −626 210 −466 −720 275394 45 96 359 117 −369 −294 −249 — −9 −7942 −8984 −894 −1115 −701−1378 * * 115(T) 1598 −1522 −3726 −3555 −2787 −2149 −2868 −1443 −3288−2470 −1892 −2585 −2799 −2974 −3213 −1463 2927 1522 −3313 −3022 141 —−149 −500 233 43 −381 399 106 −626 210 −466 −720 275 394 45 96 359 117−369 −294 −249 — −9 −7942 −8984 −894 −1115 −701 −1378 * * 116(M 845−1514 −3507 −3305 −2427 −2152 −2615 −1675 −2968 −2025 4655 −2481 −2760−2728 −2908 −1457 695 −1444 −2989 −2699 142 — −149 −500 233 43 −381 399106 −626 210 −466 −720 275 394 45 96 359 117 −369 −294 −249 — −9 −7942−8984 −894 −1115 −701 −1378 * * 117(M 103 −2295 −4810 −4261 −1123 −4222−3233 −505 −3905 1982 4088 −3963 −4004 −3263 −3656 −3428 −2527 −1018−2542 −2485 143 — −149 −500 233 43 −381 399 106 −626 210 −466 −720 275394 45 96 359 117 −369 −294 −249 — −9 −7942 −8984 −894 −1115 −701−1378 * * 118(V 249 −1764 −4559 −4171 −2124 −3892 −3557 400 −3936 216−1010 −3749 −3970 −3700 −3906 −3157 −2087 3302 −3297 −2917 144 — −149−500 233 43 −381 399 106 −626 210 −466 −720 275 394 45 96 359 117 −369−294 −249 — −9 −7942 −8984 −894 −1115 −701 −1378 * * 119(Y −1748 −2787−1867 −1117 −3134 −2580 −896 −2823 2430 −2708 −1928 −1262 −2616 −4821298 588 −1603 −2513 −2720 2852 145 — −149 −500 233 43 −381 399 106 −626210 −466 −720 275 394 45 96 359 117 −369 −294 −249 — −9 −7942 −8984 −894−1115 −701 −1378 * * 120(M 543 −1502 454 −655 −1569 −2005 −725 −11521280 1097 2617 −860 −2092 −451 −910 −972 −801 −975 −1856 −1371 146 —−149 −500 233 43 −381 399 106 −626 210 −466 −720 275 394 45 96 359 117−369 −294 −249 — −9 −7942 −8984 −894 −1115 −701 −1378 * * 121(G −2913−3668 945 −1911 −5049 3566 −2931 −5265 −3381 −5155 −4587 −2191 −3583−2748 −4001 −2853 −3188 −4499 −4671 −4461 147 — −149 −500 233 43 −381399 106 −626 210 −466 −720 275 394 45 96 359 117 −369 −294 −249 — −9−7942 −8984 −894 −1115 −701 −1378 * * 122(E) 418 −2234 1260 1822 −2533−1769 −443 −2271 1177 −485 −1330 −412 −1871 9 −542 −693 −747 −1845 −2428811 148 — −149 −500 233 43 −381 399 106 −626 210 −466 −720 275 394 45 96359 117 −369 −294 −249 — −9 −7942 −8984 −894 −1115 −701 −1378 * * 123(V2475 −1721 −4141 −4120 −2951 −2548 −3488 −657 −3886 −2245 −1927 −3055−3187 −3584 −3760 −1902 −1766 2703 −3796 −3475 149 — −149 −500 233 43−381 399 106 −626 210 −466 −720 275 394 45 96 359 117 −369 −294 −249 —−9 −7942 −8984 −894 −1115 −701 −1378 * * 124(D −4232 −4465 4158 −2649−5412 −3676 −3575 −6036 −4125 −5722 −5419 −2993 −4216 −3512 −4617 −4077−4401 −5553 −4696 −4914 150 — −149 −500 233 43 −381 399 106 −626 210−466 −720 275 394 45 96 359 117 −369 −294 −249 — −9 −7942 −8984 −894−1115 −701 −1378 * * 125(G −1595 −2107 −3720 −3963 −3970 3471 −3570−3119 −3981 −3886 −3293 −2985 −3155 −3665 −3837 −1865 −2027 946 −4215−4068 151 — −149 −500 233 43 −381 399 106 −626 210 −466 −720 275 394 4596 359 117 −369 −294 −249 — −9 −7942 −8984 −894 −1115 −701 −1378 * *126(M −2025 2478 −4388 −3797 −1130 −3739 −2667 −158 −3453 1208 4105−3402 −3608 −2937 −3236 −2881 −1961 880 −2231 −2028 152 — −149 −500 23343 −381 399 106 −626 210 −466 −720 275 394 45 96 359 117 −369 −294 −249— −9 −7942 −8984 −894 −1115 −701 −1378 * * 127(W −150 757 49 299 −277−651 839 −485 392 −910 599 300 −401 623 162 −99 38 −448 1107 126 153 —−149 −500 233 43 −381 399 106 −626 210 −466 −720 275 394 45 96 359 117−369 −294 −249 — −9 −7942 −8984 −894 −1115 −701 −1378 * * 128(V −2447−1962 −5103 −4789 −2553 −4857 −4827 1666 −4719 −1334 −1279 −4568 −4656−4638 −4849 −4228 −2447 3448 −4233 −3737 154 — −149 −500 233 43 −381 399106 −626 210 −466 −720 275 394 45 96 359 117 −369 −294 −249 — −9 −7942−8984 −894 −1115 −701 −1378 * * 129(S) 2131 −1670 −3692 −3910 −4174−1935 −3404 −3963 −3845 −4238 −3317 −2599 −2728 −3415 −3673 2964 −1517−2788 −4397 −4269 155 — −149 −500 233 43 −381 399 106 −626 210 −466 −720275 394 45 96 359 117 −369 −294 −249 — −9 −7942 −8984 −894 −1115 −701−1378 * * 130(G −4088 −3924 −4774 −5139 −5615 3825 −4753 −6303 −5453−6014 −5662 −4812 −4539 −5232 −5106 −4370 −4472 −5527 −4696 −5561 156 —−149 −500 233 43 −381 399 106 −626 210 −466 −720 275 394 45 96 359 117−369 −294 −249 — −9 −7942 −8984 −894 −1115 −701 −1378 * * 131(A 3075−1760 −2603 −2695 −3957 −1941 −2800 −3736 −2952 −3942 −3051 1370 −2670−2640 −3110 792 −1502 −2723 −4139 −3839 157 — −149 −500 233 43 −381 399106 −626 210 −466 −720 275 394 45 96 359 117 −369 −294 −249 — −9 −7942−8984 −894 −1115 −701 −1378 * * 132(V 1970 −1618 −4439 −3946 −1865 −3942−3147 1777 −3693 528 −807 −3588 −3866 −3412 −3626 −3130 −1942 2096 −2880−2511 158 — −149 −500 233 43 −381 399 106 −626 210 −466 −720 275 394 4596 359 117 −369 −294 −249 — −9 −7942 −8984 −894 −1115 −701 −1378 * *133(H −1102 2379 −1738 −1466 −2663 −2010 4358 −2506 −1383 −2678 −1892969 −2465 −1337 −1706 783 −1293 −2046 −2891 −2346 159 — −149 −500 233 43−381 399 106 −626 210 −466 −720 275 394 45 96 359 117 −369 −294 −249 —−9 −7942 −8984 −894 −1115 −701 −1378 * * 134(S) 419 −1643 −3250 −3104−3814 −1905 −2857 −3555 −2981 −3781 −2885 −2311 2298 −2716 −3080 23971614 −2583 −4014 −3764 160 — −149 −500 233 43 −381 399 106 −626 210 −466−720 275 394 45 96 359 117 −369 −294 −249 — −9 −7942 −8984 −894 −1115−701 −1378 * * 135(T) −1102 −1714 −3480 −3700 −4076 −1973 −3311 −3843−3648 −4140 −3265 −2565 −2755 −3310 −3525 656 3729 −2765 −4307 −4127 161— −149 −500 233 43 −381 399 106 −626 210 −466 −720 275 394 45 96 359 117−369 −294 −249 — −9 −7942 −8984 −894 −1115 −701 −1378 * * 136(G 2443−1650 −3680 −3879 −4195 2494 −3389 −3992 −3844 −4243 −3304 −2574 −2707−3388 −3682 672 −1492 −2786 −4412 −4299 162 — −149 −500 233 43 −381 399106 −626 210 −466 −720 275 394 45 96 359 117 −369 −294 −249 — −9 −7942−8984 −894 −1115 −701 −1378 * * 137(D −2610 −4414 3375 −640 −4704 −2395−1885 −4787 −2296 −4632 −4069 2731 −2988 −1589 −3253 −2255 −2733 −4206−4710 −3683 163 — −149 −500 233 43 −381 399 106 −626 210 −466 −720 275394 45 96 359 117 −369 −294 −249 — −9 −7942 −8984 −894 −1115 −701−1378 * * 138(T) −1802 −1610 −4107 −3628 −1625 −3434 −2777 121 −3310 979−612 −3213 −3529 −3008 −3231 −2634 2771 1888 −2588 −2269 164 — −149 −500233 43 −381 399 106 −626 210 −466 −720 275 394 45 96 359 117 −369 −294−249 — −9 −7942 −8984 −894 −1115 −701 −1378 * * 139(L) −2900 −2445 −5330−4886 −1470 −4921 −4106 −73 −4643 2578 −286 −4689 −4527 −3948 −4403−4253 −2850 2224 −3114 −3047 165 — −149 −500 233 43 −381 399 106 −626210 −466 −720 275 394 45 96 359 117 −369 −294 −249 — −9 −7942 −8984 −894−1115 −701 −1378 * * 140(R −4488 −4181 −4789 −4318 −5193 −4148 −3436−5568 −2393 −5152 −4748 −4156 −4479 −3286 4202 −4614 −4467 −5273 −4267−4649 166 — −149 −500 233 43 −381 399 106 −626 210 −466 −720 275 394 4596 359 117 −369 −294 −249 — −9 −7942 −8984 −894 −1115 −701 −1378 * *141(P) 1695 −1951 −3539 −3802 −4288 −2189 −3492 −4075 −3870 −4341 −3515−2772 3709 −3517 −3739 −1609 −1819 −3017 −4404 −4341 167 — −149 −500 23343 −381 399 106 −626 210 −466 −720 275 394 45 96 359 117 −369 −294 −249— −9 −7942 −8984 −894 −1115 −701 −1378 * * 142(A 2997 −1820 −3672 −3957−4327 2092 −3531 −4137 −4026 −4400 −3498 −2726 −2859 −3569 −3834 −1467−1684 −2957 −4469 −4425 168 — −149 −500 233 43 −381 399 106 −626 210−466 −720 275 394 45 96 359 117 −369 −294 −249 — −9 −7942 −8984 −894−1115 −701 −1378 * * 143(L) −3221 −2748 −5558 −5092 −1274 −5134 −4164−386 −4812 3030 −86 −4956 −4613 −3913 −4456 −4503 −3148 772 −2987 −3018169 — −149 −500 233 43 −381 399 106 −626 210 −466 −720 275 394 45 96 359117 −369 −294 −249 — −9 −7942 −8984 −894 −1115 −701 −1378 * * 144(Q−2871 −3512 −2899 −2161 −4235 −3278 −1502 −3869 −191 −3535 −2901 −2118−3368 4099 1519 −2774 −2657 −3608 −3317 −3159 170 — −149 −500 233 43−381 399 106 −626 210 −466 −720 275 394 45 96 359 117 −369 −294 −249 —−9 −7942 −8984 −894 −1115 −701 −1378 * * 145(I) −2460 −1967 −5122 −4804−2546 −4899 −4864 3420 −4742 −1315 −1266 −4595 −4676 −4657 −4875 −4271−2457 2106 −4245 −3757 171 — −149 −500 233 43 −381 399 106 −626 210 −466−720 275 394 45 96 359 117 −369 −294 −249 — −9 −7942 −8984 −894 −1115−701 −1378 * * 146(I) −2482 −1984 −5127 −4768 −2335 −4912 −4643 3097−4684 313 −1075 −4568 −4633 −4487 −4753 −4252 −2463 2302 −3978 −3593 172— −149 −500 233 43 −381 399 106 −626 210 −466 −720 275 394 45 96 359 117−369 −294 −249 — −9 −7942 −8984 −894 −1115 −701 −1378 * * 147(K −2698−3306 −2555 −2385 −4613 1689 −2226 −4379 3466 −4176 −3510 −2406 −3487−1898 −1272 −2718 −2789 −3870 −3879 −3804 173 — −149 −500 233 43 −381399 106 −626 210 −466 −720 275 394 45 96 359 117 −369 −294 −249 — −9−7942 −8984 −894 −1115 −701 −1378 * * 148(T) −1775 −2078 −3737 −3648−2269 −2758 −3026 −1461 −3198 577 −1417 −3004 −3304 −3108 −3140 −21443610 −1504 −3171 −2809 174 — −149 −500 233 43 −381 399 106 −626 210 −466−720 275 394 45 96 359 117 −369 −294 −249 — −9 −7942 −8984 −894 −1115−701 −1378 * * 149(K 1442 −2243 −1132 −565 −2592 −2073 −704 −2218 2425−2266 −1439 −805 −2179 1424 −419 −1063 −1056 139 −2490 −1948 175 — −149−500 233 43 −381 399 106 −626 210 −466 −720 275 394 45 96 359 117 −369−294 −249 — −9 −7942 −8984 −894 −1115 −701 −1378 * * 150(P) −2229 −3531−751 745 −4074 −2482 −1471 −3788 860 −3650 −2934 −1174 3599 −1104 −1174−2025 −2220 −3370 −3701 −3125 176 — −149 −500 233 43 −381 399 106 −626210 −466 −720 275 394 45 96 359 117 −369 −294 −249 — −9 −7942 −8984 −894−1115 −701 −1378 * * 151(G −4088 −3924 −4774 −5139 −5615 3825 −4753−6303 −5453 −6014 −5662 −4812 −4539 −5232 −5106 −4370 −4472 −5527 −4696−5561 177 — −149 −500 233 43 −381 399 106 −626 210 −466 −720 275 394 4596 359 117 −369 −294 −249 — −9 −7942 −8984 −894 −1115 −701 −1378 * *152(C 1031 2336 −3000 −2410 −865 −2361 −1377 −341 −2075 407 −99 −2001−2486 −1756 −1986 688 649 1750 −1361 −1013 178 — −149 −500 233 43 −381399 106 −626 210 −466 −720 275 394 45 96 359 117 −369 −294 −249 — −9−7942 −8984 −894 −1115 −701 −1378 * * 153(K 299 −2345 −751 −248 −2698−1882 2125 −2424 2532 −2376 −1479 830 −1996 −103 −500 327 −894 −1997−2541 −1898 179 — −149 −500 233 43 −381 399 106 −626 210 −466 −720 275394 45 96 359 117 −369 −294 −249 — −9 −7942 −8984 −894 −1115 −701−1378 * * 154(T) −908 −953 −2280 −1684 −935 −2313 −1108 722 344 1215−140 −1590 −2372 −1223 1008 −1350 1552 668 −1392 −1018 180 — −149 −500233 43 −381 399 106 −626 210 −466 −720 275 394 45 96 359 117 −369 −294−249 — −9 −7942 −8984 −894 −1115 −701 −1378 * * 155(V 248 −1426 −4165−3634 −1671 −3597 −2693 2073 −3341 492 −700 −3234 −3564 −3048 −3243−2750 488 2467 −2499 −2124 181 — −149 −500 233 43 −381 399 106 −626 210−466 −720 275 394 45 96 359 117 −369 −294 −249 — −9 −7942 −8984 −894−1115 −701 −1378 * * 156(S) −1944 −2458 −3696 −4011 −4410 −2644 −3753−4675 −4191 −4807 −4070 −3198 −3384 −3886 −4051 3656 −2393 −3615 −4374−4307 182 — −149 −500 233 43 −381 399 106 −626 210 −466 −720 275 394 4596 359 117 −369 −294 −249 — −9 −7942 −8984 −894 −1115 −701 −1378 * *157(G 693 −1658 −3600 −3793 −4209 2495 −3362 −4011 −3794 −4256 −3314−2553 −2706 −3347 −3658 2479 −1495 −2797 −4419 −4298 183 — −149 −500 23343 −381 399 106 −626 210 −466 −720 275 394 45 96 359 117 −369 −294 −249— −9 −7942 −8984 −894 −1115 −701 −1378 * * 158(F) 757 −848 −3195 −25882258 −2533 −1456 1163 −2229 −678 −69 −2151 −2599 −1889 −2097 1006 −9491406 −1371 −1020 184 — −149 −500 233 43 −381 399 106 −626 210 −466 −720275 394 45 96 359 117 −369 −294 −249 — −9 −7942 −8984 −894 −1115 −701−1378 * * 159(F) −3561 −3044 −5093 −4992 4144 −4702 −2042 −1417 −4612−651 2173 −3997 −4516 −3679 −4183 −4055 −3507 −1990 −1263 −230 185 —−149 −500 233 43 −381 399 106 −626 210 −466 −720 275 394 45 96 359 117−369 −294 −249 — −9 −7942 −8984 −894 −1115 −701 −1378 * * 160(I) −2399−1985 −4894 −4389 1240 −4436 −3536 2456 −4148 1300 −435 −4090 −4179−3651 −3986 −3652 −2345 2073 −2927 −2716 186 — −149 −500 233 43 −381 399106 −626 210 −466 −720 275 394 45 96 359 117 −369 −294 −249 — −9 −7942−8984 −894 −1115 −701 −1378 * * 161(M −2968 −2569 −5237 −4809 −1359−4763 −3886 1091 −4419 −34 4848 −4576 −4450 −3792 −4170 −4116 −2930 −673−2953 −2839 187 — −149 −500 233 43 −381 399 106 −626 210 −466 −720 275394 45 96 359 117 −369 −294 −249 — −9 −7942 −8984 −894 −1115 −701−1378 * * 162(Q 309 −798 −2699 −2096 1118 −2361 −1203 789 −1796 499 6−1823 −2416 1904 −1779 902 −818 786 −1249 −892 188 — −149 −500 233 43−381 399 106 −626 210 −466 −720 275 394 45 96 359 117 −369 −294 −249 —−9 −7942 −8984 −894 −1115 −701 −1378 * * 163(V −884 −1453 −1331 −759−1529 −2054 −754 426 1538 −1352 −623 −938 708 −503 609 −1024 716 1556−1814 −1348 189 — −149 −500 233 43 −381 399 106 −626 210 −466 −720 275394 45 96 359 117 −369 −294 −249 — −9 −7942 −8984 −894 −1115 −701−1378 * * 164(P) −1205 −2096 −1371 −1294 −3530 1986 −1732 −3286 −1522−3357 −2495 −1382 2600 1480 −1930 689 −1438 −2587 −3557 −3013 190 — −149−500 233 43 −381 399 106 −626 210 −466 −720 275 394 45 96 359 117 −369−294 −249 — −9 −7942 −8984 −894 −1115 −701 −1378 * * 165(D −1308 −28642377 1708 −3151 −1969 −847 −2932 908 −2865 −1984 1026 −2212 −422 −1139−1136 −1274 −2473 −3039 1438 191 — −149 −500 233 43 −381 399 106 −626210 −466 −720 275 394 45 96 359 117 −369 −294 −249 — −9 −7942 −8984 −894−1115 −701 −1378 * * 166(C 544 3117 −563 1527 −2011 −1598 −229 −1884 984−1975 −920 −317 −1617 1132 −431 −599 −614 −1564 −1347 −1372 192 — −149−500 233 43 −381 399 106 −626 210 −466 −720 275 394 45 96 359 117 −369−294 −249 — −9 −7942 −8984 −894 −1115 −701 −1378 * * 167(E) −1135 −2652805 2212 −2960 449 −701 −2724 −352 −2658 −1760 −534 −2098 1133 1725 −983−1089 −2270 −2825 −2111 193 — −149 −500 233 43 −381 399 106 −626 210−466 −720 275 394 45 96 359 117 −369 −294 −249 — −9 −7942 −8984 −894−1115 −701 −1378 * * 168(Y −3596 −3426 −4011 −4236 −756 −3926 −2017−3923 −4119 −3489 −3396 −3558 1274 −3712 −3935 −3640 −3783 −3834 −14234617 194 — −149 −500 233 43 −381 399 106 −626 210 −466 −720 275 394 4596 359 117 −369 −294 −249 — −809 −7942 −1234 −894 −1115 −701 −1378 * *169(G −2666 −2751 −3377 −3700 −4393 3753 −3528 −4841 −4031 −4741 −4286−3394 −3411 −3824 −3848 −2912 −3053 −4080 −3719 −4290 195 — −149 −500233 43 −381 399 106 −626 210 −466 −720 275 394 45 96 359 117 −369 −294−249 — −15 −7148 −8190 −894 −1115 −2275 −334 * * 170(H −909 −2472 16481963 −2749 −1496 2279 −2536 −207 −2473 −1609 −112 −1774 −16 −789 911−884 −2079 −2655 −1892 196 — −149 −500 233 43 −381 399 106 −626 210 −466−720 275 394 45 96 359 117 −369 −294 −249 — −15 −7148 −8190 −894 −1115−2275 −334 * * 171(D −1659 −3544 3062 1534 −3720 −1620 −946 −3633 −1158−3508 −2820 1807 −2140 −608 −1992 −1327 −1718 −3114 −3702 −2701 197 —−149 −500 233 43 −381 399 106 −626 210 −466 −720 275 394 45 96 359 117−369 −294 −249 — −15 −7148 −8190 −894 −1115 −2275 −334 * * 172(G −2666−2751 −3377 −3700 −4393 3753 −3528 −4841 −4031 −4741 −4286 −3394 −3411−3824 −3848 −2912 −3053 −4080 −3719 −4290 198 — −149 −500 233 43 −381399 106 −626 210 −466 −720 275 394 45 96 359 117 −369 −294 −249 — −15−7148 −8190 −894 −1115 −1358 −713 * * 173(M 896 −558 −2670 −2060 1251−2185 −1048 43 −1731 665 2262 −1717 −2232 −1411 −1654 −1259 1662 83−1007 −665 199 — −149 −500 233 43 −381 399 106 −626 210 −466 −720 275394 45 96 359 117 −369 −294 −249 — −13 −7414 −8456 −894 −1115 −1982−421 * * 174(L) −3012 −2483 −4991 −4588 2563 −4681 −2567 −365 −4286 2641286 −4144 −4140 −3283 −3862 −3990 −2889 −1078 −1633 −952 200 — −149 −500233 43 −381 399 106 −626 210 −466 −720 275 394 45 96 359 117 −369 −294−249 — −13 −7414 −8456 −894 −1115 −249 −2660 * * 175(V −1666 −1535 −3931−3496 −1547 517 −2575 −46 −3176 1766 −593 −3023 −3348 −2859 −3069 −2394−1705 2567 −2418 −2089 201 — −149 −500 233 43 −381 399 106 −626 210 −466−720 275 394 45 96 359 117 −369 −294 −249 — −9 −7942 −8984 −894 −1115−701 −1378 * * 176(F) −4576 −3559 −5015 −5343 4263 −4881 −1152 −3449−4910 −2776 −2865 −3550 −4757 −3679 −4300 −4154 −4444 −3622 −401 2124202 — −149 −500 233 43 −381 399 106 −626 210 −466 −720 275 394 45 96 359117 −369 −294 −249 — −9 −7942 −8984 −894 −1115 −701 −1378 * * 177(A 3345−1674 −3727 −3977 −4175 −1941 −3439 −3955 −3910 −4243 −3329 −2621 −2737−3468 −3709 825 −1527 −2788 −4405 −4282 203 — −149 −500 233 43 −381 399106 −626 210 −466 −720 275 394 45 96 359 117 −369 −294 −249 — −9 −7942−8984 −894 −1115 −701 −1378 * * 178(W −150 757 49 299 −277 −651 839 −485392 −910 599 300 −401 623 162 −99 38 −448 1107 126 204 — −149 −500 23343 −381 399 106 −626 210 −466 −720 275 394 45 96 359 117 −369 −294 −249— −9 −7942 −8984 −894 −1115 −701 −1378 * * 179(D −4232 −4465 4158 −2649−5412 −3676 −3575 −6036 −4125 −5722 −5419 −2993 −4216 −3512 −4617 −4077−4401 −5553 −4696 −4914 205 — −149 −500 233 43 −381 399 106 −626 210−466 −720 275 394 45 96 359 117 −369 −294 −249 — −9 −7942 −8984 −894−1115 −701 −1378 * * 180(C −1236 5496 −4197 −4463 −4068 −2103 −3603−3911 −4139 −4251 −3414 −2867 −2893 −3739 −3846 647 −1702 −2864 −4296−4138 206 — −149 −500 233 43 −381 399 106 −626 210 −466 −720 275 394 4596 359 117 −369 −294 −249 — −9 −7942 −8984 −894 −1115 −701 −1378 * *181(A 2681 −1648 −3686 −3867 −4184 2067 −3375 −3979 −3817 −4229 −3291−2570 −2704 −3369 −3665 954 −1488 −2779 −4401 −4284 207 — −149 −500 23343 −381 399 106 −626 210 −466 −720 275 394 45 96 359 117 −369 −294 −249— −9 −7942 −8984 −894 −1115 −701 −1378 * * 182(V −2422 −1967 −4993 −4556−1946 −4647 −4007 2482 −4386 447 1863 −4301 −4388 −4024 −4325 −3914−2387 2602 −3399 −3128 208 — −149 −500 233 43 −381 399 106 −626 210 −466−720 275 394 45 96 359 117 −369 −294 −249 — −9 −7942 −8984 −894 −1115−701 −1378 * * 183(N −1642 −1630 −3011 −2702 −1675 −3027 −2261 −141−2480 399 −827 3044 −3220 −2357 −2577 −2236 −1678 2152 −2448 −1987 209 —−149 −500 233 43 −381 399 106 −626 210 −466 −720 275 394 45 96 359 117−369 −294 −249 — −9 −7942 −8984 −894 −1115 −701 −1378 * * 184(I) −1310−1421 −2217 1185 −1569 −2673 −1609 2204 −1689 −1167 −660 −1843 2154−1552 −1934 −1762 −1280 885 −2135 −1720 210 — −149 −500 233 43 −381 399106 −626 210 −466 −720 275 394 45 96 359 117 −369 −294 −249 — −9 −7942−8984 −894 −1115 −701 −1378 * * 185(N 257 1558 440 612 −2481 −1765 −435−2211 −31 −2194 1330 2360 −1863 1379 −534 −683 −729 −1796 −2393 −1727211 — −149 −500 233 43 −381 399 106 −626 210 −466 −720 275 394 45 96 359117 −369 −294 −249 — −9 −7942 −8984 −894 −1115 −701 −1378 * * 186(P)−2875 −3093 −3978 −4134 −3333 −3398 −3665 −3255 −3879 −167 −2945 −37274087 −3894 −3795 −3160 −3199 −3243 −3784 −3483 212 — −149 −500 233 43−381 399 106 −626 210 −466 −720 275 394 45 96 359 117 −369 −294 −249 —−9 −7942 −8984 −894 −1115 −701 −1378 * * 187(T) −1617 −2991 2432 −518−3614 −2086 −1314 −3413 −1230 −3383 −2559 996 −2497 −937 −1848 429 2498−2889 −3583 −2811 213 — −149 −500 233 43 −381 399 106 −626 210 −466 −720275 394 45 96 359 117 −369 −294 −249 — −9 −7942 −8984 −894 −1115 −701−1378 * * 188(A 2241 −1737 −1506 513 −2489 −1943 −1317 −2071 −1119 −2312−1526 −1230 −2307 −1010 −1520 1714 −1101 416 −2692 −2195 214 — −149 −500233 43 −381 399 106 −626 210 −466 −720 275 394 45 96 359 117 −369 −294−249 — −9 −7942 −8984 −894 −1115 −701 −1378 * * 189(E) 525 −2429 17761822 −2741 −1821 −551 −2497 −176 −2443 −1530 −453 124 1127 −700 −809 481−2048 −2615 −1917 215 — −149 −500 233 43 −381 399 106 −626 210 −466 −720275 394 45 96 359 117 −369 −294 −249 — −9 −7942 −8984 −894 −1115 −701−1378 * * 190(Q −1567 −3175 1704 1474 −3449 −2060 −1054 −3249 −877 −3174−2325 −671 −2377 2979 −1481 −1362 1084 −2781 −3353 −2563 216 — −149 −500233 43 −381 399 106 −626 210 −466 −720 275 394 45 96 359 117 −369 −294−249 — −9 −7942 −8984 −894 −1115 −701 −1378 * * 191(L) −3337 −2808 −5707−5127 −1152 −5377 −4133 −460 −4878 2928 1801 −5079 −4636 −3831 −4452−4675 −3207 697 −2886 −3022 217 — −149 −500 233 43 −381 399 106 −626 210−466 −720 275 394 45 96 359 117 −369 −294 −249 — −9 −7942 −8984 −894−1115 −701 −1378 * * 192(A 3213 −1669 −3729 −3963 −4171 −1937 −3427−3953 −3889 −4236 −3319 −2614 −2732 −3450 −3697 1430 −1520 −2784 −4399−4276 218 — −149 −500 233 43 −381 399 106 −626 210 −466 −720 275 394 4596 359 117 −369 −294 −249 — −9 −7942 −8984 −894 −1115 −701 −1378 * *193(E) −2200 −4049 2514 2580 −4247 −2234 −1519 −4143 −1674 −4022 −33011158 −2729 −1171 −2473 318 −2248 −3627 −4213 −3243 219 — −149 −500 23343 −381 399 106 −626 210 −466 −720 275 394 45 96 359 117 −369 −294 −249— −9 −7942 −8984 −894 −1115 −701 −1378 * * 194(I) −2474 −2002 −5104−4792 −2432 −4811 −4734 3681 −4697 −1199 −1182 −4556 −4627 −4560 −4788−4186 −2477 1241 −4098 −3650 220 — −149 −500 233 43 −381 399 106 −626210 −466 −720 275 394 45 96 359 117 −369 −294 −249 — −9 −7942 −8984 −894−1115 −701 −1378 * * 195(A 3609 −2508 −4184 −4493 −4592 −2737 −3989−4421 −4496 −4701 −4051 −3440 −3474 −4171 −4253 −2294 −2487 −3536 −4484−4643 221 — −149 −500 233 43 −381 399 106 −626 210 −466 −720 275 394 4596 359 117 −369 −294 −249 — −9 −7942 −8984 −894 −1115 −701 −1378 * *196(I) −1091 −1076 −2583 413 −1145 −2551 −1453 2635 −1815 −911 −317−1908 −2625 −1603 −1923 −64 352 1441 −1667 −1289 222 — −149 −500 233 43−381 399 106 −626 210 −466 −720 275 394 45 96 359 117 −369 −294 −249 —−9 −7942 −8984 −894 −1115 −701 −1378 * * 197(Q 518 −2071 −706 1236 −2329−1787 −464 158 −79 −2066 −1190 −460 −1883 1523 −571 1071 1153 −1661−2309 −1673 223 — −149 −500 233 43 −381 399 106 −626 210 −466 −720 275394 45 96 359 117 −369 −294 −249 — −9 −7942 −8984 −894 −1115 −701−1378 * * 198(S) 690 −1632 −3665 −3707 −4013 −1911 −3224 −3755 −3549−4023 −3114 −2519 −2683 −3185 −3470 2818 2263 −2676 −4240 −4079 224 —−149 −500 233 43 −381 399 106 −626 210 −466 −720 275 394 45 96 359 117−369 −294 −249 — −9 −7942 −8984 −894 −1115 −701 −1378 * * 199(A 2957−1575 −3607 −3525 −3508 456 −2992 −3142 −3331 −3468 −2642 −2460 −2661−2989 −3286 646 −1410 731 −3811 −3585 225 — −149 −500 233 43 −381 399106 −626 210 −466 −720 275 394 45 96 359 117 −369 −294 −249 — −9 −7942−8984 −894 −1115 −701 −1378 * * 200(E) 56 −2745 1143 2154 −3045 −1930−765 −2818 1875 −2752 −1859 945 −2144 −332 −1009 −1045 −1166 −2359 −2923−2190 226 — −149 −500 233 43 −381 399 106 −626 210 −466 −720 275 394 4596 359 117 −369 −294 −249 — −9 −7942 −8984 −894 −1115 −701 −1378 * *201(T) −1256 −2015 −1982 −1726 −3420 −2098 −1785 −3082 927 −3191 −2379−1663 −2604 −1463 −1433 524 3369 −2475 −3390 −2984 227 — −149 −500 23343 −381 399 106 −626 210 −466 −720 275 394 45 96 359 117 −369 −294 −249— −9 −7942 −8984 −894 −1115 −701 −1378 * * 202(W 2769 −2207 −4068 −38072256 −3458 −1352 −1888 −3438 −1847 −1513 −2925 −3632 −2881 −3227 −2665−2391 −1867 3112 296 228 — −149 −500 233 43 −381 399 106 −626 210 −466−720 275 394 45 96 359 117 −369 −294 −249 — −9 −7942 −8984 −894 −1115−701 −1378 * * 203(R −2470 −3357 −2623 1389 −4114 −3061 −1112 −3509 2409−3196 −2485 −1713 −3049 −686 2844 −2333 −2214 −3234 −3079 −2887 229 —−149 −500 233 43 −381 399 106 −626 210 −466 −720 275 394 45 96 359 117−369 −294 −249 — −540 −7942 −1697 −894 −1115 −701 −1378 * * 204(M 816−1388 −782 −226 −1511 −1668 −358 −1120 1679 119 1761 1028 −1755 −26 −458−619 −511 −896 −1709 −1189 230 — −149 −500 233 43 −381 399 106 −626 210−466 −720 275 394 45 96 359 117 −369 −294 −249 — −13 −7414 −8456 −894−1115 −249 −2660 * * 205(L) −2837 −2376 −5287 −4745 −1320 −4877 −38311365 −4505 2429 1943 −4548 −4406 −3738 −4219 −4120 −2750 1537 −2900−2889 231 — −149 −500 233 43 −381 399 106 −626 210 −466 −720 275 394 4596 359 117 −369 −294 −249 — −9 −7942 −8984 −894 −1115 −701 −1378 * *206(C −1191 2897 −3560 −2991 2519 −2720 −1807 −69 −2623 −837 −305 −2465−2840 −2267 −2460 −1855 899 2022 −1675 −1297 232 — −149 −500 233 43 −381399 106 −626 210 −466 −720 275 394 45 96 359 117 −369 −294 −249 — −9−7942 −8984 −894 −1115 −701 −1378 * * 207(G −1539 −3140 2028 −312 −34212111 −1027 −3216 685 −3138 −2285 998 −2361 1202 −1409 −1339 −1520 −2749−3312 −2532 233 — −149 −500 233 43 −381 399 106 −626 210 −466 −720 275394 45 96 359 117 −369 −294 −249 — −9 −7942 −8984 −894 −1115 −701−1378 * * 208(I) 334 −1130 401 620 −1157 −2255 −1040 2289 −1141 −9791812 −1358 −2323 −992 −1401 −1264 −866 644 −1591 −1181 234 — −149 −500233 43 −381 399 106 −626 210 −466 −720 275 394 45 96 359 117 −369 −294−249 — −9 −7942 −8984 −894 −1115 −701 −1378 * * 209(E) 425 −2447 16852151 −2749 −1843 −586 −2497 831 −2456 −1553 −477 −1993 −142 −743 −847−928 108 −2639 −1943 235 — −149 −500 235 43 −381 399 106 −626 210 −466−720 275 394 45 96 359 117 −369 −294 −249 — −169 −3204 −8984 −206 −2913−701 −1378 * * 210(P) −4497 −4117 −4899 −5251 −5560 −4139 −4798 −6328−5454 −5976 −5741 −5026 4302 −5328 −5104 −4798 −4844 −5739 −4665 −5484237 — −149 −500 233 43 −381 399 106 −626 210 −466 −720 275 394 45 96 359117 −369 −294 −249 — −9 −7942 −8984 −894 −1115 −701 −1378 * * 211(R−2896 −3530 −3730 −2192 −4456 −3379 −1195 −3707 2481 −3319 −2662 −2040−3291 1300 3145 −2762 −2535 −3495 −3134 −3075 238 — −149 −500 233 43−381 399 106 −626 210 −466 −720 275 394 45 96 359 117 −369 −294 −249 —−9 −7942 −8984 −894 −1115 −701 −1378 * * 212(V −2838 −2616 −4834 −4880−3213 −3955 −4416 −610 −4757 −2310 −2253 −4383 −4345 −4643 −4642 −3732−3007 3763 −4157 −3886 239 — −149 −500 233 43 −381 399 106 −626 210 −466−720 275 394 45 96 359 117 −369 −294 −249 — −9 −7942 −8984 −894 −1115−701 −1378 * * 213(A 3345 −1674 −3727 −3977 −4175 −1941 −3439 −3955−3910 −4243 −3329 −2621 −2737 −3468 −3709 825 −1527 −2788 −4405 −4282240 — −149 −500 233 43 −381 399 106 −626 210 −466 −720 275 394 45 96 359117 −369 −294 −249 — −9 −7942 −8984 −894 −1115 −701 −1378 * * 214(M−3386 −2926 −5503 −5047 −1187 −5101 −3953 −644 −4586 916 4893 −4906−4599 −3801 −4244 −4517 −3301 −1338 −2841 −2779 241 — −149 −500 233 43−381 399 106 −626 210 −466 −720 275 394 45 96 359 117 −369 −294 −249 —−9 −7942 −8984 −894 −1115 −701 −1378 * * 215(L) −4119 −3542 −5389 −5357−2027 −4767 −4359 −1609 −5118 3293 −979 −5230 −4771 −4474 −4724 −5069−4106 −2331 −3412 −3400 242 — −149 −500 233 43 −381 399 106 −626 210−466 −720 275 394 45 96 359 117 −369 −294 −249 — −9 −7942 −8984 −894−1115 −701 −1378 * * 216(S) −1944 −2458 −3696 −4011 −4410 −2644 −3753−4675 −4191 −4807 −4070 −3198 −3384 −3886 −4051 3656 −2393 −3615 −4374−4307 243 — −149 −500 233 43 −381 399 106 −626 210 −466 −720 275 394 4596 359 117 −369 −294 −249 — −9 −7942 −8984 −894 −1115 −701 −1378 * *217(F) −4596 −3564 −5022 −5356 4100 −4892 −1140 −3474 −4920 −2799 −2888−3546 −4763 −3678 −4303 −4158 −4459 −3642 −389 2808 244 — −149 −500 23343 −381 399 106 −626 210 −466 −720 275 394 45 96 359 117 −369 −294 −249— −9 −7942 −8984 −894 −1115 −701 −1378 * * 218(S) −1944 −2458 −3696−4011 −4410 −2644 −3753 −4675 −4191 −4807 −4070 −3198 −3384 −3886 −40513656 −2393 −3615 −4374 −4307 245 — −149 −500 233 43 −381 399 106 −626210 −466 −720 275 394 45 96 359 117 −369 −294 −249 — −9 −7942 −8984 −894−1115 −701 −1378 * * 219(T) −1086 −1700 −3489 −3680 −4071 −1960 −3290−3842 −3622 −4127 −3243 −2550 −2741 −3278 −3511 1633 3501 −2755 −4299−4122 246 — −149 −500 233 43 −381 399 106 −626 210 −466 −720 275 394 4596 359 117 −369 −294 −249 — −9 −7942 −8984 −894 −1115 −701 −1378 * *220(K −1211 −2188 −1252 −684 −2201 −2183 −735 −2041 2458 −2110 2342 1770−2264 −372 −433 −1182 −1128 −1772 −2263 1110 247 — −149 −500 233 43 −381399 106 −626 210 −466 −720 275 394 45 96 359 117 −369 −294 −249 — −9−7942 −8984 −894 −1115 −701 −1378 * * 221(G −4088 −3924 −4774 −5139−5615 3825 −4753 −6303 −5453 −6014 −5662 −4812 −4539 −5232 −5106 −4370−4472 −5527 −4696 −5561 248 — −149 −500 233 43 −381 399 106 −626 210−466 −720 275 394 45 96 359 117 −369 −294 −249 — −9 −7942 −8984 −894−1115 −701 −1378 * * 222(S) −1944 −2458 −3696 −4011 −4410 −2644 −3753−4675 −4191 −4807 −4070 −3198 −3384 −3886 −4051 3656 −2393 −3615 −4374−4307 249 — −149 −500 233 43 −381 399 106 −626 210 −466 −720 275 394 4596 359 117 −369 −294 −249 — −9 −7942 −8984 −894 −1115 −701 −1378 * *223(A 3609 −2508 −4184 −4493 −4592 −2737 −3989 −4421 −4496 −4701 −4051−3440 −3474 −4171 −4253 −2294 −2487 −3536 −4484 −4643 250 — −149 −500233 43 −381 399 106 −626 210 −466 −720 275 394 45 96 359 117 −369 −294−249 — −9 −7942 −8984 −894 −1115 −701 −1378 * * 224(K −2345 −3215 −2680−1702 −4004 −2994 −1114 −3430 3145 −3150 −2429 −1707 −3005 −690 15371210 −2130 −3134 −3052 −2847 251 — −149 −500 233 43 −381 399 106 −626210 −466 −720 275 394 45 96 359 117 −369 −294 −249 — −9 −7942 −8984 −894−1115 −701 −1378 * * 225(H −1041 −1842 −1795 −1535 −3225 1554 2940 −2958−1555 −3088 −2233 −1512 −2445 −1442 −1925 2143 928 −2312 −3333 −2843 252— −149 −500 233 43 −381 399 106 −626 210 −466 −720 275 394 45 96 359 117−369 −294 −249 — −9 −7942 −8984 −894 −1115 −701 −1378 * * 226(P) −1812−3493 1638 2272 −3746 −2139 −1234 −3572 714 −3480 −2668 −741 2320 −848−1793 −1570 −1815 −3091 −3658 −2819 253 — −149 −500 233 43 −381 399 106−626 210 −466 −720 275 394 45 96 359 117 −369 −294 −249 — −9 −7942 −8984−894 −1115 −701 −1378 * * 227(M −1063 −1672 −1185 1731 −1647 −2144 −910−1218 −725 1142 2726 1099 −2261 −651 −1101 −1179 −1008 −1100 −2011 −1532254 — −149 −500 233 43 −381 399 106 −626 210 −466 −720 275 394 45 96 359117 −369 −294 −249 — −9 −7942 −8984 −894 −1115 −701 −1378 * * 228(W −150757 49 299 −277 −651 839 −485 392 −910 599 300 −401 623 162 −99 38 −4481107 126 255 — −149 −500 233 43 −381 399 106 −626 210 −466 −720 275 39445 96 359 117 −369 −294 −249 — −9 −7942 −8984 −894 −1115 −701 −1378 * *229(V −1683 −1779 −4225 −4114 −2704 −2952 −3573 −161 −3855 −1868 −1633−3296 −3474 −3653 −3791 −2302 2073 3159 −3712 −3334 256 — −149 −500 23343 −381 399 106 −626 210 −466 −720 275 394 45 96 359 117 −369 −294 −249— −9 −7942 −8984 −894 −1115 −701 −1378 * * 230(E) 576 −3124 2215 2294−3448 −2061 −1092 −3240 −936 −3183 −2340 −696 −2393 −692 −1547 −13751093 −2772 −3374 −2589 257 — −149 −500 233 43 −381 399 106 −626 210 −466−720 275 394 45 96 359 117 −369 −294 −249 — −9 −7942 −8984 −894 −1115−701 −1378 * * 231(K 315 −2794 −1360 −1079 −3606 −2397 −1201 −3242 3269−3135 −2344 1290 −2657 −798 −553 −1655 −1723 −2800 −3186 −2733 258 —−149 −500 233 43 −381 399 106 −626 210 −466 −720 275 394 45 96 359 117−369 −294 −249 — −9 −7942 −8984 −894 −1115 −701 −1378 * * 232(V −1806−1830 −4356 −4254 −2729 −3152 −3789 −6 −4016 −1803 −1616 −3476 −3637−3839 −3966 −2513 660 3495 −3859 −3459 259 — −149 −500 233 43 −381 399106 −626 210 −466 −720 275 394 45 96 359 117 −369 −294 −249 — −9 −7942−8984 −894 −1115 −701 −1378 * * 233(Q 793 −1527 −1108 −552 −1618 −19471457 1157 637 −1440 −683 −772 −2030 1773 −839 −896 518 491 −1868 −1365260 — −149 −500 233 43 −381 399 106 −626 210 −466 −720 275 394 45 96 359117 −369 −294 −249 — −9 −7942 −8984 −894 −1115 −701 −1378 * * 234(E) 300−2398 695 1659 −2713 −1806 −518 −2470 1395 −2411 −1494 1531 −1936 1405−648 −775 −852 −2018 −2579 −1883 261 — −149 −500 233 43 −381 399 106−626 210 −466 −720 275 394 45 96 359 117 −369 −294 −249 — −9 −7942 −8984−894 −1115 −701 −1378 * * 235(A 3370 −1675 −3725 −3979 −4176 −1943 −3442−3956 −3915 −4245 −3332 −2623 −2739 −3473 −3712 667 −1529 −2789 −4406−4283 262 — −149 −500 233 43 −381 399 106 −626 210 −466 −720 275 394 4596 359 117 −369 −294 −249 — −9 −7942 −8984 −894 −1115 −701 −1378 * *236(T) −1487 −1747 −4009 −3951 −2829 −2596 −3358 −658 −3663 −2137 −1837−3024 −3208 −3442 −3576 −1949 3247 2128 −3661 −3318 263 — −149 −500 23343 −381 399 106 −626 210 −466 −720 275 394 45 96 359 117 −369 −294 −249— −9 −7942 −8984 −894 −1115 −701 −1378 * * 237(K 78 −2444 −636 1476−2774 −1872 −554 −2516 2347 −2450 −1542 1061 −1996 1188 −567 −849 −918−2073 −2605 −1935 264 — −149 −500 233 43 −381 399 106 −626 210 −466 −720275 394 45 96 359 117 −369 −294 −249 — −9 −7942 −8984 −894 −1115 −701−1378 * * 238(L) −2340 −2043 −4429 −3825 −1249 −4051 −2880 2209 47 2445−154 −3576 −3849 −2947 −3012 −3227 −2264 −489 −2490 −2321 265 — −149−500 233 43 −381 399 106 −626 210 −466 −720 275 394 45 96 359 117 −369−294 −249 — −9 −7942 −8984 −894 −1115 −701 −1378 * * 239(A 3066 −1532−3416 −3204 −2546 −2126 −2613 −1745 −2919 251 −1678 −2434 −2743 −2680−2903 −1429 721 −1481 −3078 −2775 266 — −149 −500 233 43 −381 399 106−626 210 −466 −720 275 394 45 96 359 117 −369 −294 −249 — −9 −7942 −8984−894 −1115 −701 −1378 * * 240(K −2775 −3478 −3431 −2065 −4356 −3299−1170 −3648 3068 −3281 −2609 −1958 −3227 2481 1606 −2643 −2444 −3419−3113 −3021 267 — −149 −500 233 43 −381 399 106 −626 210 −466 −720 275394 45 96 359 117 −369 −294 −249 — −9 −7942 −8984 −894 −1115 −701−1378 * * 241(E) 5 −3248 −527 3274 −3691 −2238 −1242 −3429 736 −3351−2559 −905 −2586 −855 −1282 −1630 −1816 −2982 −3491 −2801 268 — −149−500 233 43 −381 399 106 −626 210 −466 −720 275 394 45 96 359 117 −369−294 −249 — −9 −7942 −8984 −894 −1115 −701 −1378 * * 242(R 1203 −1274−1535 −960 714 −2112 −836 −874 1242 45 1502 −1087 −2184 −670 1607 −1097−814 −732 −1655 −1220 269 — −149 −500 233 43 −381 399 106 −626 210 −466−720 275 394 45 96 359 117 −369 −294 −249 — −9 −7942 −8984 −894 −1115−701 −1378 * * 243(A 1867 −2550 755 648 −2859 −1875 −646 −2618 −291−2563 −1661 1632 −2046 −205 1386 −915 −1009 −2170 −2737 −2031 270 — −149−500 233 43 −381 399 106 −626 210 −466 −720 275 394 45 96 359 117 −369−294 −249 — −9 −7942 −8984 −894 −1115 −701 −1378 * * 244(P) −1833 −2267−3769 −3944 −3591 −2645 −3527 −2530 −3805 −3285 −2936 −3132 3954 −3636−3703 −2130 −2228 835 −4002 −3761 271 — −149 −500 233 43 −381 399 106−626 210 −466 −720 275 394 45 96 359 117 −369 −294 −249 — −9 −7942 −8984−894 −1115 −701 −1378 * * 245(D 206 −2972 2710 1351 −3255 −2000 1755−3042 −683 −2972 −2100 −614 −2269 1462 −1262 −1213 −1369 −2579 −3148−2386 272 — −149 −500 233 43 −381 399 106 −626 210 −466 −720 275 394 4596 359 117 −369 −294 −249 — −9 −7942 −8984 −894 −1115 −701 −1378 * *246(L) −3414 −2874 −5769 −5161 1383 −5422 −4072 994 −4912 2728 2007−5118 −4630 −3791 −4438 −4708 −3264 −1344 −2810 −2947 273 — −149 −500233 43 −381 399 106 −626 210 −466 −720 275 394 45 96 359 117 −369 −294−249 — −9 −7942 −8984 −894 −1115 −701 −1378 * * 247(A 1831 −2029 575−204 −2274 −1806 −494 −1962 927 −82 −1160 −494 270 −72 −607 −735 508−1613 −2285 −1663 274 — −149 −500 233 43 −381 399 106 −626 210 −466 −720275 394 45 96 359 117 −369 −294 −249 — −9 −7942 −8984 −894 −1115 −701−1378 * * 248(I) −2431 −2000 −4947 −4466 1231 −4532 −3688 3189 −4249 517−529 −4183 −4266 −3781 −4114 −3766 −2383 1363 −3060 −2816 275 — −149−500 233 43 −381 399 106 −626 210 −466 −720 275 394 45 96 359 117 −369−294 −249 — −9 −7942 −8984 −894 −1115 −701 −1378 * * 249(D −4232 −44654158 −2649 −5412 −3676 −3575 −6036 −4125 −5722 −5419 −2993 −4216 −3512−4617 −4077 −4401 −5553 −4696 −4914 276 — −149 −500 233 43 −381 399 106−626 210 −466 −720 275 394 45 96 359 117 −369 −294 −249 — −9 −7942 −8984−894 −1115 −701 −1378 * * 250(G −4088 −3924 −4774 −5139 −5615 3825 −4753−6303 −5453 −6014 −5662 −4812 −4539 −5232 −5106 −4370 −4472 −5527 −4696−5561 277 — −149 −500 233 43 −381 399 106 −626 210 −466 −720 275 394 4596 359 117 −369 −294 −249 — −9 −7942 −8984 −894 −1115 −701 −1378 * *251(E) −4205 −4417 −2343 3901 −5349 −3698 −3534 −5837 −3838 −5561 −5237−3039 −4218 −3453 −4201 −4072 −4352 −5409 −4640 −4860 278 — −149 −500233 43 −381 399 106 −626 210 −466 −720 275 394 45 96 359 117 −369 −294−249 — −9 −7942 −8984 −894 −1115 −701 −1378 * * 252(L) −3602 −3015 −5919−5328 1158 −5654 −4138 −616 −5093 2938 2013 −5330 −4744 −3877 −4575−4984 −3438 −1455 −2794 −2838 279 — −149 −500 233 43 −381 399 106 −626210 −466 −720 275 394 45 96 359 117 −369 −294 −249 — −9 −7942 −8984 −894−1115 −701 −1378 * * 253(Q −4207 −4117 −3531 −3731 −4752 −3930 −3721−5554 −3395 −5179 −4897 −3823 −4399 4556 −3405 −4301 −4380 −5208 −4301−4384 280 — −149 −500 233 43 −381 399 106 −626 210 −466 −720 275 394 4596 359 117 −369 −294 −249 — −9 −7942 −8984 −894 −1115 −701 −1378 * *254(F) −2863 −2433 −5172 −4640 3169 −4702 −3234 −392 −4348 1785 −84−4307 −4290 −3544 −4021 −3916 −2769 1504 −2393 −2005 281 — −149 −500 23343 −381 399 106 −626 210 −466 −720 275 394 45 96 359 117 −369 −294 −249— −9 −7942 −8984 −894 −1115 −701 −1378 * * 255(D −4232 −4465 4158 −2649−5412 −3676 −3575 −6036 −4125 −5722 −5419 −2993 −4216 −3512 −4617 −4077−4401 −5553 −4696 −4914 282 — −149 −500 233 43 −381 399 106 −626 210−466 −720 275 394 45 96 359 117 −369 −294 −249 — −9 −7942 −8984 −894−1115 −701 −1378 * * 256(A 3609 −2508 −4184 −4493 −4592 −2737 −3989−4421 −4496 −4701 −4051 −3440 −3474 −4171 −4253 −2294 −2487 −3536 −4484−4643 283 — −149 −500 233 43 −381 399 106 −626 210 −466 −720 275 394 4596 359 117 −369 −294 −249 — −9 −7942 −8984 −894 −1115 −701 −1378 * *257(A 3186 −1669 −3728 −3961 −4171 −1936 −3425 −3953 −3886 −4235 −3318−2613 −2731 −3447 −3695 1524 −1520 −2783 −4398 −4275 284 — −149 −500 23343 −381 399 106 −626 210 −466 −720 275 394 45 96 359 117 −369 −294 −249— −9 −7942 −8984 −894 −1115 −701 −1378 * * 258(F) −3002 −2525 −5316−4818 3177 −4924 −3350 2613 −4551 818 −147 −4496 −4441 −3703 −4215 −4169−2905 −737 −2444 −1989 285 — −149 −500 233 43 −381 399 106 −626 210 −466−720 275 394 45 96 359 117 −369 −294 −249 — −9 −7942 −8984 −894 −1115−701 −1378 * * 259(V −2294 −2438 724 −2485 −3071 −3156 −3064 −720 −3372−2390 −2164 −2598 −3629 −2975 −3716 −2757 −2460 3538 −3861 −3370 286 —−149 −500 233 43 −381 399 106 −626 210 −466 −720 275 394 45 96 359 117−369 −294 −249 — −9 −7942 −8984 −894 −1115 −701 −1378 * * 260(P) −1594−2934 −619 588 −3418 −2163 −1118 −3148 755 −3092 −2272 −870 3320 −720−1108 321 −1590 −2706 −3251 −2595 287 — −149 −500 233 43 −381 399 106−626 210 −466 −720 275 394 45 96 359 117 −369 −294 −249 — −9 −7942 −8984−894 −1115 −701 −1378 * * 261(E) 232 −2432 −633 1887 −2799 −1880 −622−2541 1768 −2491 −1591 −543 −2032 −178 −679 1460 −962 −2096 −2660 −1989288 — −149 −500 233 43 −381 399 106 −626 210 −466 −720 275 394 45 96 359117 −369 −294 −249 — −9 −7942 −8984 −894 −1115 −701 −1378 * * 262(V−2838 −2616 −4834 −4880 −3213 −3955 −4416 −610 −4757 −2310 −2253 −4383−4345 −4643 −4642 −3732 −3007 3763 −4157 −3886 289 — −149 −500 233 43−381 399 106 −626 210 −466 −720 275 394 45 96 359 117 −369 −294 −249 —−9 −7942 −8984 −894 −1115 −701 −1378 * * 263(A 3303 −1827 −3692 −3978−4328 1129 −3541 −4137 −4037 −4403 −3503 −2739 −2867 −3583 −3840 −1477−1693 −2962 −4468 −4428 290 — −149 −500 233 43 −381 399 106 −626 210−466 −720 275 394 45 96 359 117 −369 −294 −249 — −9 −7942 −8984 −894−1115 −701 −1378 * * 264(E) 1471 −2341 669 1713 −2646 −1806 −509 −23891384 −680 −1440 −444 −1930 −60 −624 −766 −833 −1955 −2531 −1848 291 —−149 −500 233 43 −381 399 106 −626 210 −466 −720 275 394 45 96 359 117−369 −294 −249 — −9 −7942 −8984 −894 −1115 −701 −1378 * * 265(Q 236−2063 −853 −302 −2314 −1882 −542 −1988 1473 779 −1199 −578 −1977 1845−534 1012 −820 −1652 −2307 −1712 292 — −149 −500 233 43 −381 399 106−626 210 −466 −720 275 394 45 96 359 117 −369 −294 −249 — −9 −7942 −8984−894 −1115 −701 −1378 * * 266(K −4125 −4091 −4017 −3615 −5101 −3960−2958 −5182 3972 −4825 −4345 −3552 −4249 −2709 −1809 −4154 −4044 −4895−4132 −4389 293 — −149 −500 233 43 −381 399 106 −626 210 −466 −720 275394 45 96 359 117 −369 −294 −249 — −9 −7942 −8984 −894 −1115 −701−1378 * * 267(A 3348 −2109 −3336 −3412 −1764 −2509 −2437 −2956 −3286−3118 −2630 −2708 −3150 −3050 −3249 −1903 −2016 −2533 −2364 1487 294 —−149 −500 233 43 −381 399 106 −626 210 −466 −720 275 394 45 96 359 117−369 −294 −249 — −9 −7942 −8984 −894 −1115 −701 −1378 * * 268(P) −1528−2315 −1720 −1687 −3833 −2233 −1895 −3559 797 −3582 −2793 −1690 3653−1574 −1445 406 −1768 −2881 −3673 −3270 295 — −149 −500 233 43 −381 399106 −626 210 −466 −720 275 394 45 96 359 117 −369 −294 −249 — −9 −7942−8984 −894 −1115 −701 −1378 * * 269(G −1935 −3089 2442 −885 −4418 2762−1974 −4330 −2285 −4310 −3586 −1182 −2821 −1681 −3048 394 −2183 −3549−4481 −3646 296 — −149 −500 233 43 −381 399 106 −626 210 −466 −720 275394 45 96 359 117 −369 −294 −249 — −9 −7942 −8984 −894 −1115 −701−1378 * * 270(S) −1944 −2458 −3696 −4011 −4410 −2644 −3753 −4675 −4191−4807 −4070 −3198 −3384 −3886 −4051 3656 −2393 −3615 −4374 −4307 297 —−149 −500 233 43 −381 399 106 −626 210 −466 −720 275 394 45 96 359 117−369 −294 −249 — −9 −7942 −8984 −894 −1115 −701 −1378 * * 271(K −986−2487 579 781 −2798 −1840 −584 −2559 1709 −2499 −1588 1699 1485 −137−743 394 −935 −2105 −2668 −1964 298 — −149 −500 233 43 −381 399 106 −626210 −466 −720 275 394 45 96 359 117 −369 −294 −249 — −9 −7942 −8984 −894−1115 −701 −1378 * * 272(V −2488 −1997 −5115 −4741 −2236 −4876 −45211399 −4638 586 −992 −4534 −4596 −4394 −4675 −4204 −2466 3282 −3849 −3500299 — −149 −500 233 43 −381 399 106 −626 210 −466 −720 275 394 45 96 359117 −369 −294 −249 — −9 −7942 −8984 −894 −1115 −701 −1378 * * 273(A 2860−2613 −1445 −1105 −3345 −2365 −1181 −2968 911 −2930 −2150 −1269 −26151502 −562 −1587 −1627 −2570 −3048 −2602 300 — −149 −500 233 43 −381 399106 −626 210 −466 −720 275 394 45 96 359 117 −369 −294 −249 — −9 −7942−8984 −894 −1115 −701 −1378 * * 274(G −4088 −3924 −4774 −5139 −5615 3825−4753 −6303 −5453 −6014 −5662 −4812 −4539 −5232 −5106 −4370 −4472 −5527−4696 −5561 301 — −149 −500 233 43 −381 399 106 −626 210 −466 −720 275394 45 96 359 117 −369 −294 −249 — −9 −7942 −8984 −894 −1115 −701−1378 * * 275(H −1098 −2519 644 −333 −2880 −1987 2767 −2597 2281 −2509−1617 857 −2093 −153 1114 −970 −1024 −2167 −2636 −2015 302 — −149 −500233 43 −381 399 106 −626 210 −466 −720 275 394 45 96 359 117 −369 −294−249 — −9 −7942 −8984 −894 −1115 −701 −1378 * * 276(A 3609 −2508 −4184−4493 −4592 −2737 −3989 −4421 −4496 −4701 −4051 −3440 −3474 −4171 −4253−2294 −2487 −3536 −4484 −4643 303 — −149 −500 233 43 −381 399 106 −626210 −466 −720 275 394 45 96 359 117 −369 −294 −249 — −9 −7942 −8984 −894−1115 −701 −1378 * * 277(N −1586 −2305 −1738 −2020 −4028 −2232 −2587−3973 −2635 −4158 −3406 4054 −2920 −2402 −2900 −1720 681 −3116 −4157−3676 304 — −149 −500 233 43 −381 399 106 −626 210 −466 −720 275 394 4596 359 117 −369 −294 −249 — −9 −7942 −8984 −894 −1115 −701 −1378 * *278(V −2446 −1963 −5100 −4786 −2548 −4847 −4816 1583 −4714 −1330 −1276−4562 −4651 −4631 −4841 −4218 −2447 3468 −4224 −3729 305 — −149 −500 23343 −381 399 106 −626 210 −466 −720 275 394 45 96 359 117 −369 −294 −249— −9 −7942 −8984 −894 −1115 −701 −1378 * * 279(W −150 757 49 299 −277−651 839 −485 392 −910 599 300 −401 623 162 −99 38 −448 1107 126 306 —−149 −500 233 43 −381 399 106 −626 210 −466 −720 275 394 45 96 359 117−369 −294 −249 — −9 −7942 −8984 −894 −1115 −701 −1378 * * 280(F) −3486−2932 −5765 −5195 3114 −5447 −3820 −632 −4937 2173 2384 −5073 −4656−3798 −4452 −4740 −3334 −1436 −2628 −2474 307 — −149 −500 233 43 −381399 106 −626 210 −466 −720 275 394 45 96 359 117 −369 −294 −249 — −9−7942 −8984 −894 −1115 −701 −1378 * * 281(I) −2458 −1961 −5125 −4807−2569 −4914 −4890 3219 −4751 −1339 −1284 −4603 −4685 −4676 −4892 −4286−2453 2471 −4276 −3778 308 — −149 −500 233 43 −381 399 106 −626 210 −466−720 275 394 45 96 359 117 −369 −294 −249 — −9 −7942 −8984 −894 −1115−701 −1378 * * 282(F) −4720 −3927 −5139 −5454 4513 −4504 −2520 −3938−5326 −3307 −3429 −4469 −4782 −4575 −4818 −4787 −4810 −4172 −1812 −736309 — −149 −500 233 43 −381 399 106 −626 210 −466 −720 275 394 45 96 359117 −369 −294 −249 — −9 −7942 −8984 −894 −1115 −701 −1378 * * 283(P)−4497 −4117 −4899 −5251 −5560 −4139 −4798 −6328 −5454 −5976 −5741 −50264302 −5328 −5104 −4798 −4844 −5739 −4665 −5484 310 — −149 −500 233 43−381 399 106 −626 210 −466 −720 275 394 45 96 359 117 −369 −294 −249 —−9 −7942 −8984 −894 −1115 −701 −1378 * * 284(D −2322 −4185 3035 1469−4418 −2266 −1625 −4341 −1869 −4214 −3539 −867 −2800 −1293 −2724 1786−2396 −3805 −4409 −3395 311 — −149 −500 233 43 −381 399 106 −626 210−466 −720 275 394 45 96 359 117 −369 −294 −249 — −9 −7942 −8984 −894−1115 −701 −1378 * * 285(L) −3492 −2925 −5831 −5302 −1190 −5571 −4334974 −5050 3059 17 −5312 −4763 −3965 −4606 −4957 −3364 −1095 −2972 −3089312 — −149 −500 233 43 −381 399 106 −626 210 −466 −720 275 394 45 96 359117 −369 −294 −249 — −9 −7942 −8984 −894 −1115 −701 −1378 * * 286(Q−2004 −3769 1173 2079 −3991 −2187 −1375 −3849 −1403 −3743 −2969 1136−2626 3177 −2117 −1727 −2027 −3352 −3926 −3026 313 — −149 −500 233 43−381 399 106 −626 210 −466 −720 275 394 45 96 359 117 −369 −294 −249 —−9 −7942 −8984 −894 −1115 −701 −1378 * * 287(A 2861 2401 −3941 −3933−3713 −1915 −3209 −3405 −3647 −3703 −2846 −2573 −2679 −3249 −3498 1246795 −2497 −4004 −3830 314 — −149 −500 233 43 −381 399 106 −626 210 −466−720 275 394 45 96 359 117 −369 −294 −249 — −9 −7942 −8984 −894 −1115−701 −1378 * * 288(G 804 −1917 −3555 −3872 −4406 3488 −3564 −4245 −4053−4497 −3611 −2768 −2934 −3603 −3880 −1567 −1787 −3064 −4502 −4481 315 —−149 −500 233 43 −381 399 106 −626 210 −466 −720 275 394 45 96 359 117−369 −294 −249 — −9 −7942 −8984 −894 −1115 −701 −1378 * * 289(N −3642−3838 −3004 −3356 −4743 −3612 −3773 −5643 −4099 −5460 −5060 4378 −4185−3865 −4225 −3744 −3950 −5002 −4391 −4381 316 — −149 −500 233 43 −381399 106 −626 210 −466 −720 275 394 45 96 359 117 −369 −294 −249 — −9−7942 −8984 −894 −1115 −701 −1378 * * 290(I) −3202 −2787 −5004 −4996−2836 −4384 −4440 3937 −4838 −1815 −1871 −4704 −4600 −4683 −4704 −4353−3280 −603 −3938 −3661 317 — −149 −500 233 43 −381 399 106 −626 210 −466−720 275 394 45 96 359 117 −369 −294 −249 — −9 −7942 −8984 −894 −1115−701 −1378 * * 291(G 1452 −1874 −3596 −3903 −4376 3335 −3550 −4203 −4044−4459 −3565 −2747 −2900 −3588 −3862 −1522 −1740 −3018 −4492 −4461 318 —−149 −500 233 43 −381 399 106 −626 210 −466 −720 275 394 45 96 359 117−369 −294 −249 — −9 −7942 −8984 −894 −1115 −701 −1378 * * 292(Y −4791−3935 −4914 −5231 −815 −4530 −2178 −4357 −5024 −3745 −3807 −4206 −4772−4328 −4584 −4677 −4837 −4435 −1477 4857 319 — −149 −500 233 43 −381 399106 −626 210 −466 −720 275 394 45 96 359 117 −369 −294 −249 — −9 −7942−8984 −894 −1115 −701 −1378 * * 293(K −4125 −4091 −4017 −3615 −5101−3960 −2958 −5182 3972 −4825 −4345 −3552 −4249 −2709 −1809 −4154 −4044−4895 −4132 −4389 320 — −149 −500 233 43 −381 399 106 −626 210 −466 −720275 394 45 96 359 117 −369 −294 −249 — −9 −7942 −8984 −894 −1115 −701−1378 * * 294(I) −3130 −2603 −5572 −5096 −1392 −5301 −4317 3061 −48812084 −185 −5010 −4688 −4034 −4578 −4656 −3046 −463 −3127 −3143 321 —−149 −500 233 43 −381 399 106 −626 210 −466 −720 275 394 45 96 359 117−369 −294 −249 — −9 −7942 −8984 −894 −1115 −701 −1378 * * 295(A 2675−1535 −3836 −3683 −2774 −2214 −2959 −1215 −3410 −2393 −1857 −2670 −2859−3085 −3310 −1533 792 2057 −3350 −3057 322 — −149 −500 233 43 −381 399106 −626 210 −466 −720 275 394 45 96 359 117 −369 −294 −249 — −9 −7942−8984 −894 −1115 −701 −1378 * * 296(Q −4207 −4117 −3531 −3731 −4752−3930 −3721 −5554 −3395 −5179 −4897 −3823 −4399 4556 −3405 −4301 −4380−5208 −4301 −4384 323 — −149 −500 233 43 −381 399 106 −626 210 −466 −720275 394 45 96 359 117 −369 −294 −249 — −9 −7942 −8984 −894 −1115 −701−1378 * * 297(R −4488 −4181 −4789 −4318 −5193 −4148 −3436 −5568 −2393−5152 −4748 −4156 −4479 −3286 4202 −4614 −4467 −5273 −4267 −4649 324 —−149 −500 233 43 −381 399 106 −626 210 −466 −720 275 394 45 96 359 117−369 −294 −249 — −9 −7942 −8984 −894 −1115 −701 −1378 * * 298(F) −3500−2941 −5773 −5206 3166 −5461 −3812 −635 −4949 2227 2003 −5083 −4665−3805 −4462 −4757 −3346 −1441 −2619 −2449 325 — −149 −500 233 43 −381399 106 −626 210 −466 −720 275 394 45 96 359 117 −369 −294 −249 — −9−7942 −8984 −894 −1115 −701 −1378 * * 299(G 2279 −1650 −3675 −3870 −41962606 −3385 −3993 −3836 −4243 −3303 −2572 −2706 −3382 −3678 828 −1491−2786 −4412 −4298 326 — −149 −500 233 43 −381 399 106 −626 210 −466 −720275 394 45 96 359 117 −369 −294 −249 — −9 −7942 −8984 −894 −1115 −701−1378 * * 300(K −1571 −2888 −927 −655 −3321 2063 1468 −3019 2355 −2910−2082 920 −2447 −523 −551 −1431 −1504 −2612 −2998 −2431 327 — −149 −500233 43 −381 399 106 −626 210 −466 −720 275 394 45 96 359 117 −369 −294−249 — −9 −7942 −8984 −894 −1115 −701 −1378 * * 301(F) 2448 −2615 −4303−4172 2956 −3922 −1214 −2324 −3828 −2183 −1926 −3107 −3996 −3105 −3543−3119 −2926 −2325 −560 2239 328 — −149 −500 233 43 −381 399 106 −626 210−466 −720 275 394 45 96 359 117 −369 −294 −249 — −9 −7942 −8984 −894−1115 −701 −1378 * * 302(E) −1402 −2920 1061 2832 −3242 −2054 −879 −2998774 −2910 −2042 −672 −2284 −454 1073 −1230 −1357 −2549 −3055 −2355 329 —−149 −500 233 43 −381 399 106 −626 210 −466 −720 275 394 45 96 359 117−369 −294 −249 — −9 −7942 −8984 −894 −1115 −701 −1378 * * 303(A 3609−2508 −4184 −4493 −4592 −2737 −3989 −4421 −4496 −4701 −4051 −3440 −3474−4171 −4253 −2294 −2487 −3536 −4484 −4643 330 — −149 −500 233 43 −381399 106 −626 210 −466 −720 275 394 45 96 359 117 −369 −294 −249 — −9−7942 −8984 −894 −1115 −701 −1378 * * 304(I) −1878 −1552 −4312 −3775−1491 −3734 −2739 2447 −3471 521 −541 −3367 −3656 −3110 −3335 −2889−1832 2126 −2430 2171 331 — −149 −500 233 43 −381 399 106 −626 210 −466−720 275 394 45 96 359 117 −369 −294 −249 — −9 −7942 −8984 −894 −1115−701 −1378 * * 305(G −4088 −3924 −4774 −5139 −5615 3825 −4753 −6303−5453 −6014 −5662 −4812 −4539 −5232 −5106 −4370 −4472 −5527 −4696 −5561332 — −149 −500 233 43 −381 399 106 −626 210 −466 −720 275 394 45 96 359117 −369 −294 −249 — −9 −7942 −8984 −894 −1115 −701 −1378 * * 306(P)−4497 −4117 −4899 −5251 −5560 −4139 −4798 −6328 −5454 −5976 −5741 −50264302 −5328 −5104 −4798 −4844 −5739 −4665 −5484 333 — −149 −500 233 43−381 399 106 −626 210 −466 −720 275 394 45 96 359 117 −369 −294 −249 —−9 −7942 −8984 −894 −1115 −701 −1378 * * 307(I) −2574 −2082 −5179 −4778−2009 −4923 −4424 3104 −4656 1327 −776 −4584 −4587 −4278 −4620 −4242−2542 1595 −3640 −3399 334 — −149 −500 233 43 −381 399 106 −626 210 −466−720 275 394 45 96 359 117 −369 −294 −249 — −9 −7942 −8984 −894 −1115−701 −1378 * * 308(C −1490 2918 −3842 −3258 −1170 −3142 −2133 1934 −29021595 −258 −2806 −3152 −2528 −2741 −2266 1394 65 −1929 −1611 335 — −149−500 233 43 −381 399 106 −626 210 −466 −720 275 394 45 96 359 117 −369−294 −249 — −9 −7942 −8984 −894 −1115 −701 −1378 * * 309(Q −4207 −4117−3531 −3731 −4752 −3930 −3721 −5554 −3395 −5179 −4897 −3823 −4399 4556−3405 −4301 −4380 −5208 −4301 −4384 336 — −149 −500 233 43 −381 399 106−626 210 −466 −720 275 394 45 96 359 117 −369 −294 −249 — −9 −7942 −8984−894 −1115 −701 −1378 * * 310(G −4088 −3924 −4774 −5139 −5615 3825 −4753−6303 −5453 −6014 −5662 −4812 −4539 −5232 −5106 −4370 −4472 −5527 −4696−5561 337 — −149 −500 233 43 −381 399 106 −626 210 −466 −720 275 394 4596 359 117 −369 −294 −249 — −9 −7942 −8984 −894 −1115 −701 −1378 * *311(L) −3686 −3084 −5727 −5319 2036 −5453 −3331 −789 −5052 2929 −88−4966 −4743 −3883 −4542 −4837 −3542 −1589 −2266 −1680 338 — −149 −500233 43 −381 399 106 −626 210 −466 −720 275 394 45 96 359 117 −369 −294−249 — −9 −7942 −8984 −894 −1115 −701 −1378 * * 312(A 2898 −1987 −2240−2485 −4049 −2085 −2826 −3885 −3004 −4117 −3288 2707 −2813 −2683 −3186−1506 −1726 −2917 −4217 −3861 339 — −149 −500 233 43 −381 399 106 −626210 −466 −720 275 394 45 96 359 117 −369 −294 −249 — −9 −7942 −8984 −894−1115 −701 −1378 * * 313(K 1066 −2626 −1795 −1052 −3050 −2498 −872 −26182866 −2563 1526 −1206 −2543 −458 1142 −1556 −1494 −2321 −2682 −2281 340— −149 −500 233 43 −381 399 106 −626 210 −466 −720 275 394 45 96 359 117−369 −294 −249 — −9 −7942 −8984 −894 −1115 −701 −1378 * * 314(P) −4497−4117 −4899 −5251 −5560 −4139 −4798 −6328 −5454 −5976 −5741 −5026 4302−5328 −5104 −4798 −4844 −5739 −4665 −5484 341 — −149 −500 233 43 −381399 106 −626 210 −466 −720 275 394 45 96 359 117 −369 −294 −249 — −9−7942 −8984 −894 −1115 −701 −1378 * * 315(V −2475 −1980 −5117 −4752−2317 −4893 −4598 2349 −4663 557 −1062 −4548 −4617 −4458 −4725 −4228−2455 2932 −3943 −3564 342 — −149 −500 233 43 −381 399 106 −626 210 −466−720 275 394 45 96 359 117 −369 −294 −249 — −9 −7942 −8984 −894 −1115−701 −1378 * * 316(H 173 −2262 −944 −767 −3091 −1973 2974 −2865 −947−2905 −2052 2949 −2338 −840 −1414 1020 −1292 −2346 −3104 −2474 343 —−149 −500 233 43 −381 399 106 −626 210 −466 −720 275 394 45 96 359 117−369 −294 −249 — −9 −7942 −8984 −894 −1115 −701 −1378 * * 317(D −4232−4465 4158 −2649 −5412 −3676 −3575 −6036 −4125 −5722 −5419 −2993 −4216−3512 −4617 −4077 −4401 −5553 −4696 −4914 344 — −149 −500 233 43 −381399 106 −626 210 −466 −720 275 394 45 96 359 117 −369 −294 −249 — −9−7942 −8984 −894 −1115 −701 −1378 * * 318(L) −4119 −3542 −5389 −5357−2027 −4767 −4359 −1609 −5118 3293 −979 −5230 −4771 −4474 −4724 −5069−4106 −2331 −3412 −3400 345 — −149 −500 233 43 −381 399 106 −626 210−466 −720 275 394 45 96 359 117 −369 −294 −249 — −9 −7942 −8984 −894−1115 −701 −1378 * * 319(S) −1944 −2458 −3696 −4011 −4410 −2644 −3753−4675 −4191 −4807 −4070 −3198 −3384 −3886 −4051 3656 −2393 −3615 −4374−4307 346 — −149 −500 233 43 −381 399 106 −626 210 −466 −720 275 394 4596 359 117 −369 −294 −249 — −9 −7942 −8984 −894 −1115 −701 −1378 * *320(R −4488 −4181 −4789 −4318 −5193 −4148 −3436 −5568 −2393 −5152 −4748−4156 −4479 −3286 4202 −4614 −4467 −5273 −4267 −4649 347 — −149 −500 23343 −381 399 106 −626 210 −466 −720 275 394 45 96 359 117 −369 −294 −249— −9 −7942 −8984 −894 −1115 −701 −1378 * * 321(G −4088 −3924 −4774 −5139−5615 3825 −4753 −6303 −5453 −6014 −5662 −4812 −4539 −5232 −5106 −4370−4472 −5527 −4696 −5561 348 — −149 −500 233 43 −381 399 106 −626 210−466 −720 275 394 45 96 359 117 −369 −294 −249 — −9 −7942 −8984 −894−1115 −701 −1378 * * 322(C −1383 5545 −4327 −4558 −4019 −2243 −3671−3414 −4157 −3975 −3301 −3006 −3016 −3818 −3871 −1656 540 −2675 −4269−4170 349 — −149 −500 233 43 −381 399 106 −626 210 −466 −720 275 394 4596 359 117 −369 −294 −249 — −9 −7942 −8984 −894 −1115 −701 −1378 * *323(S) −1998 −3389 920 −646 −4194 −2202 −1688 −4095 −1857 −4037 −33011873 −2745 −1360 −2596 2972 −2145 −3473 −4215 −3333 350 — −149 −500 23343 −381 399 106 −626 210 −466 −720 275 394 45 96 359 117 −369 −294 −249— −9 −7942 −8984 −894 −1115 −701 −1378 * * 324(A 1796 −2218 759 1121−2509 −1874 −667 −2198 −343 −2259 −1405 −578 −2039 −254 −849 333 −9371127 −2521 −1880 351 — −149 −500 233 43 −381 399 106 −626 210 −466 −720275 394 45 96 359 117 −369 −294 −249 — −9 −7942 −8984 −894 −1115 −701−1378 * * 325(E) −2264 −4130 1161 3061 −4316 −2257 −1556 −4221 −1720−4092 −3390 −846 −2763 2340 −2512 −1940 −2316 −3705 −4277 −3299 352 —−149 −500 233 43 −381 399 106 −626 210 −466 −720 275 394 45 96 359 117−369 −294 −249 — −9 −7942 −8984 −894 −1115 −701 −1378 * * 326(D −33−4335 3607 1205 −4570 −2294 −1708 −4511 −2035 −4382 −3756 −897 −2858−1390 −2952 −2084 −2528 −3963 −4583 −3525 353 — −149 −500 233 43 −381399 106 −626 210 −466 −720 275 394 45 96 359 117 −369 −294 −249 — −9−7942 −8984 −894 −1115 −701 −1378 * * 327(I) −2456 −1959 −5125 −4808−2580 −4919 −4900 3012 −4754 −1350 −1292 −4605 −4688 −4684 −4898 −4291−2452 2731 −4288 −3786 354 — −149 −500 233 43 −381 399 106 −626 210 −466−720 275 394 45 96 359 117 −369 −294 −249 — −9 −7942 −8984 −894 −1115−701 −1378 * * 328(Y −2065 −1703 −4458 −4000 −1497 −3978 −2824 1512−3720 −1096 −877 −3567 −3903 −3404 −3627 −3169 −2033 2744 −2424 2949 355— −149 −500 233 43 −381 399 106 −626 210 −466 −720 275 394 45 96 359 117−369 −294 −249 — 9— −7942 −8984 −894 −1115 −701 −1378 * * 329(K −1420−3005 1129 1097 −3290 1087 −935 −3080 2093 −3005 −2135 1724 −2283 −517−1280 −1233 −1393 −2613 −3178 −2412 356 — −149 −500 233 43 −381 399 106−626 210 −466 −720 275 394 45 96 359 117 −369 −294 −249 — −9 −7942 −8984−894 −1115 −701 −1378 * * 330(W −150 757 49 299 −277 −651 839 −485 392−910 599 300 −401 623 162 −99 38 −448 1107 126 357 — −149 −500 233 43−381 399 106 −626 210 −466 −720 275 394 45 96 359 117 −369 −294 −249 —−9 −7942 −8984 −894 −1115 −701 −1378 * * 331(V 242 −1739 −4505 −4069−1901 −3865 −3328 339 −3811 1145 −812 −3662 −3892 −3515 −3741 −3100−2045 3053 −3031 −2693 358 — −149 −500 233 43 −381 399 106 −626 210 −466−720 275 394 45 96 359 117 −369 −294 −249 — −9 −7942 −8984 −894 −1115−701 −1378 * * 332(A 2785 −1548 −3757 −3706 −3183 −2010 −3016 −2274−3464 −3018 −2323 −2559 −2725 −3105 −3346 519 −1436 1956 −3604 −3353 359— −149 −500 233 43 −381 399 106 −626 210 −466 −720 275 394 45 96 359 117−369 −294 −249 — −9 −7942 −8984 −894 −1115 −701 −1378 * * 333(A 2301−1785 −4329 −3814 −1389 −3715 −2881 1608 −3501 1601 −328 −3440 −3685−3079 −3364 −2901 −2013 −142 −2516 −2281 360 — −149 −500 233 43 −381 399106 −626 210 −466 −720 275 394 45 96 359 117 −369 −294 −249 — −9 −7942−8984 −894 −1115 −701 −1378 * * 334(I) −2461 −1969 −5121 −4803 −2539−4894 −4855 3457 −4740 −1307 −1260 −4593 −4673 −4650 −4870 −4267 −24582020 −4235 −3750 361 — −149 −500 233 43 −381 399 106 −626 210 −466 −720275 394 45 96 359 117 −369 −294 −249 — −9 −7942 −8984 −894 −1115 −701−1378 * * 335(T) 1694 −1679 −3770 −3955 −4023 −1971 −3381 −3579 −3783−3994 −3161 −2633 −2754 −3407 −3608 −1339 3474 −2625 −4286 −4150 362 —−149 −500 233 43 −381 399 106 −626 210 −466 −720 275 394 45 96 359 117−369 −294 −249 — −9 −7942 −8984 −894 −1115 −701 −1378 * * 336(A 31452363 −4124 −4092 −3068 −2102 −3176 −1748 −3745 −2761 −2179 −2727 −2812−3341 −3530 −1439 −1489 622 −3594 −3345 363 — −149 −500 233 43 −381 399106 −626 210 −466 −720 275 394 45 96 359 117 −369 −294 −249 — −9 −7942−8984 −894 −1115 −701 −1378 * * 337(V 1549 −1561 −3980 −3800 −2617 −2450−3066 −638 −3529 −2084 −1647 −2851 −3038 −3217 −3427 −1764 645 3033−3323 −3003 364 — −149 −500 233 43 −381 399 106 −626 210 −466 −720 275394 45 96 359 117 −369 −294 −249 — −9 −7942 −8984 −894 −1115 −701−1378 * * 338(Q −1998 −3480 −470 1001 −3872 −2292 −1373 −3668 −1085−3566 −2804 −947 1060 3783 −1533 −1779 −2007 −3214 −3690 −2964 365 —−149 −500 233 43 −381 399 106 −626 210 −466 −720 275 394 45 96 359 117−369 −294 −249 — −9 −7942 −8984 −894 −1115 −701 −1378 * * 339(A 2845−1741 −2441 −2116 −3476 181 −2133 −3194 −1899 −3346 −2475 −1852 −2527−1850 1122 752 −1333 −2425 −3579 −3191 366 — −149 −500 233 43 −381 399106 −626 210 −466 −720 275 394 45 96 359 117 −369 −294 −249 — −9 −7942−8984 −894 −1115 −701 −1378 * * 340(Q 288 −1371 −2820 −2256 −1089 −2819−1668 1024 −1933 1596 −165 −2151 −2848 2772 −2022 −1891 −1329 −469 −1817−1496 367 — −149 −500 233 43 −381 399 106 −626 210 −466 −720 275 394 4596 359 117 −369 −294 −249 — −444 −7942 −1940 −894 −1115 −701 −1378 * *341(A 2553 −1499 −1618 −1106 −1437 −1994 −884 −1437 −516 −1637 −947−1150 −2220 −717 1070 −1116 −989 −1219 −1772 1598 368 — −149 −500 233 43−381 399 106 −626 210 −466 −720 275 394 45 96 359 117 −369 −294 −249 —−154 −7510 −3381 −894 −1115 −1844 −471 * * 342(Q −840 −2183 2051 46−2487 478 −471 −2205 −189 −2230 −1379 −273 −1821 2234 −719 −721 −813 565−2466 −1782 369 — −149 −500 233 43 −381 399 106 −626 210 −466 −720 275394 45 96 359 117 −369 −294 −249 — −13 −7368 −8411 −894 −1115 −2041−402 * * 343(K −542 −1518 903 −68 −1686 266 −294 542 1621 −1463 −666−332 −1689 78 −434 −539 −484 817 −1827 −1263 370 — −149 −500 233 43 −381399 106 −626 210 −466 −720 275 394 45 96 359 117 −369 −294 −249 — −435−7368 −1975 −894 −1115 −2041 −402 * * 344(K 842 −1833 1221 299 −2188−1329 −107 −1924 1349 −1907 −1015 −8 −1492 329 −247 1153 −413 −1495−2105 −1431 371 — −149 −500 233 43 −381 399 106 −626 210 −466 −720 275394 45 96 359 117 −369 −294 −249 — −1110 −6951 −919 −894 −1115 −2432−296 * * 345(R −956 −1423 −1186 −681 −1830 −1454 −276 −1686 690 −1640−1095 −694 −1696 14 3253 −1003 −929 −1464 −1574 −1319 372 — −149 −500233 43 −381 399 106 −626 210 −466 −720 275 394 45 96 359 117 −369 −294−249 — −37 −5878 −6920 −894 −1115 −2888 −209 * * 346(E) −804 −1735 4972874 −2096 −1058 −327 −1858 −157 −1967 −1380 40 −1471 −39 −568 −688 −853−1562 −2027 −1547 373 — −149 −500 233 43 −381 399 106 −626 210 −466 −720275 394 45 96 359 117 −369 −294 −249 — −37 −5878 −6920 −894 −1115 −2888−209 * * 347(R −956 −1423 −1186 −681 −1830 −1454 −276 −1686 690 −1640−1095 −694 −1696 14 3253 −1003 −929 −1464 −1574 −1319 374 — −149 −500233 43 −381 399 106 −626 210 −466 −720 275 394 45 96 359 117 −369 −294−249 — −37 −5878 −6920 −894 −1115 −2888 −209 * * 348(S) 227 −390 −660−668 −1564 −565 −762 −1409 −705 −1690 −1020 −460 −1182 −625 −900 2604−94 −861 −1818 −1338 375 — −149 −500 233 43 −381 399 106 −626 210 −466−720 275 394 45 96 359 117 −369 −294 −249 — −37 −5878 −6920 −894 −1115−2888 −209 * * 349(L) −1162 −1035 −2273 −2015 −35 −2243 −1374 599 −15872466 801 −1903 −2350 −1486 −1587 −1745 −1181 283 −1141 −718 376 — −149−500 233 43 −381 399 106 −626 210 −466 −720 275 394 45 96 359 117 −369−294 −249 — −37 −5878 −6920 −894 −1115 −2888 −209 * * 350(H −948 −1353−590 −533 −353 −1374 4354 −1609 −210 −1544 −1090 −628 −1716 −415 −369−985 −1004 −1409 −758 74 377 — −149 −500 233 43 −381 399 106 −626 210−466 −720 275 394 45 96 359 117 −369 −294 −249 — −37 −5878 −6920 −894−1115 −2888 −209 * * 351(T) 71 −435 −987 −905 −1386 −761 −851 −654 −738−1152 −667 −673 −1327 −733 −889 −159 2865 −370 −1730 −1351 378 — −149−500 233 43 −381 399 106 −626 210 −466 −720 275 394 45 96 359 117 −369−294 −249 — −37 −5878 −6920 −894 −1115 −2888 −209 * * 352(L) −1162 −1035−2273 −2015 −35 −2243 −1374 599 −1587 2466 801 −1903 −2350 −1486 −1587−1745 −1181 283 −1141 −718 379 — −149 −500 233 43 −381 399 106 −626 210−466 −720 275 394 45 96 359 117 −369 −294 −249 — −37 −5878 −6920 −894−1115 −2888 −209 * * 353(V −558 −557 −2112 −1895 −730 −1799 −1509 1150−1619 15 149 −1639 −2121 −1558 −1693 −1183 −681 2778 −1647 −1187 380 —−149 −500 233 43 −381 399 106 −626 210 −466 −720 275 394 45 96 359 117−369 −294 −249 — −37 −5878 −6920 −894 −1115 −2888 −209 * * 354(E) −804−1735 497 2874 −2096 −1058 −327 −1858 −157 −1967 −1380 40 −1471 −39 −568−688 −853 −1562 −2027 −1547 381 — −149 −500 233 43 −381 399 106 −626 210−466 −720 275 394 45 96 359 117 −369 −294 −249 — −37 −5878 −6920 −894−1115 −127 −3565 * * 355(W −150 757 49 299 −277 −651 839 −485 392 −910599 300 −401 623 162 −99 38 −448 1107 126 382— * * * * * * * * * * * * * * * * * * * * — * * * * * * * * 0

1. A recombinant host cell comprising: (i) at least one deletion,mutation, or substitution, or combinations thereof, in an endogenousgene encoding a polypeptide that converts pyruvate to acetaldehyde,acetyl-phosphate or acetyl-CoA; and (ii) a heterologous polynucleotideencoding a polypeptide having phosphoketolase activity.
 2. Therecombinant host cell of claim 1, wherein the polypeptide that convertspyruvate to acetaldehyde, acetyl-phosphate or acetyl-CoA is pyruvatedecarboxylase, pyruvate-formate lyase, pyruvate dehydrogenase, pyruvateoxidase, or pyruvate:ferredoxin oxidoreductase.
 3. The recombinant hostcell of claim 1, wherein said host cell further comprises: (iii) aheterologous polynucleotide encoding a polypeptide havingphosphotransacetylase activity.
 4. The recombinant host cell of claim 1,wherein said host cell has a reduced requirement for an exogenoustwo-carbon substrate for its growth in culture compared to a recombinanteukaryotic host cell comprising (i) and not (ii) or (iii).
 5. Arecombinant host cell comprising: (i) at least one deletion, mutation,and/or substitution in an endogenous gene encoding a polypeptide havingpyruvate decarboxylase activity; and (ii) a heterologous polynucleotideencoding a polypeptide having phosphoketolase activity.
 6. Therecombinant host cell of claim 5, wherein said host cell furthercomprises: (iii) a heterologous polynucleotide encoding a polypeptidehaving phosphotransacetylase activity.
 7. The recombinant host cell ofclaim 5, wherein said host cell has a reduced requirement for anexogenous two-carbon substrate for its growth in culture compared to arecombinant eukaryotic host cell comprising (i) and not (ii) or (iii).8. The recombinant host cell of claim 5, wherein said host cell hasimproved growth as compared to a host cell comprising (i) and not (ii)or (iii) in culture media that is not supplemented with an exogenouscarbon substrate.
 9. The recombinant host cell of claim 8, wherein saidexogenous two-carbon substrate is ethanol or acetate.
 10. Therecombinant host cell of claim 3, comprising at least one deletion,mutation, and/or substitution in an endogenous gene encoding apolypeptide having pyruvate decarboxylase activity wherein said at leastone deletion, mutation, and/or substitution results in pyruvatedecarboxylase activity that is reduced or eliminated.
 11. Therecombinant host cell of any one of claim 10, wherein said endogenousgene encoding a polypeptide having pyruvate decarboxylase activity isPDC1, PDC5, PDC6, or combinations thereof and said host cell is S.cerevisiae.
 12. The recombinant host cell of claim 5, wherein saidheterologous polynucleotide encoding a polypeptide havingphosphoketolase activity is xpk1 from Lactobacillus plantarum, xpkA fromLactobacillus pentosus MD363 or 6-phosphate phosphoketolase from B.lactis.
 13. The recombinant host cell of claim 5 wherein saidpolypeptide having phosphoketolase activity comprises at least 85%identity to SEQ ID NO: 481 or an active fragment thereof.
 14. Therecombinant host cell of claim 6, wherein said heterologouspolynucleotide encoding a polypeptide having phosphotransacetylaseactivity is EutD from Lactobacillus plantarum or phosphotransacetylasefrom Bacillus subtilis.
 15. The recombinant host cell of claim 6,wherein said polypeptide comprises at least 85% identity to SEQ ID NO:1472 or an active fragment thereof.
 16. The recombinant host cell of anyone of claim 5, wherein said host cell is a member of the generaClostridium, Zymomonas, Escherichia, Salmonella, Serratia, Erwinia,Klebsiella, Shigella, Rhodococcus, Pseudomonas, Bacillus, Lactobacillus,Enterococcus, Alcaligenes, Klebsiella, Paenibacillus, Arthrobacter,Corynebacterium, Brevibacterium, Schizosaccharomyces, Kluyveromyces,Yarrowia, Pichia, Candida, Hansenula, or Saccharomyces.
 17. Therecombinant host cell of claim 5 wherein said host cell is Saccharomycescerevisiae.
 18. The recombinant host cell of claim 5 further comprisinga pyruvate-utilizing biosynthetic pathway, wherein saidpyruvate-utilizing biosynthetic pathway forms a product selected fromthe group consisting of: 2,3-butanediol, 2-butanol, 2-butanone, valine,leucine, lactic acid, malate, and isoamyl alcohol.
 19. The recombinanthost cell of claim 5, further comprising a pyruvate-utilizingbiosynthetic pathway wherein said pyruvate-utilizing biosyntheticpathway is an isobutanol biosynthetic pathway comprising the substrateto product conversions: (i) pyruvate to acetolactate; (ii) acetolactateto 2,3-dihydroxyisovalerate; (iii) 2,3-dihydroxyisovalerate to2-ketoisovalerate; (iv) 2-ketoisovalerate to isobutyraldehyde; and (v)isobutyraldehyde to isobutanol; and wherein said recombinant host cellproduces isobutanol.
 20. The recombinant host cell of claim 18, whereinsaid pyruvate-utilizing biosynthetic pathway is a 2-butanonebiosynthetic pathway comprising the substrate to product conversions:(i) pyruvate to acetolactate; (ii) acetolactate to acetoin; (iii)acetoin to 2,3-butanediol; and (iv) 2,3-butanediol to 2-butanone; andwherein said recombinant host cell produces 2-butanone.
 21. Therecombinant host cell of claim 18, wherein said pyruvate-utilizingbiosynthetic pathway is a 2-butanol biosynthetic pathway comprising thesubstrate to product conversions: (i) pyruvate to acetolactate; (ii)acetolactate to acetoin; (iii) acetoin to 2,3-butanediol; (iv)2,3-butanediol to 2-butanone; and (v) 2-butanone to 2-butanol; andwherein said recombinant host cell produces 2-butanol.
 22. A method forthe production of 2,3-butanediol, 2-butanol, 2-butanone, valine,leucine, lactic acid, malic acid, alanine, fumaric acid, succinic acidor isoamyl alcohol comprising growing the recombinant host cell of claim18 under conditions wherein the product is produced and optionallyrecovering the product.
 23. A method for the production of isobutanolcomprising growing the recombinant host cell of claim 19 underconditions wherein the product is produced and optionally recovering theproduct.
 24. The method of claim 22, wherein said recombinant host cellcomprises a 2-butanone biosynthetic pathway comprising at least one DNAmolecule encoding a polypeptide that catalyzes a substrate to productconversion selected from the group consisting of: (i) pyruvate toacetolactate; (ii) acetolactate to acetoin; (iii) acetoin to2,3-butanediol; and (iv) 2,3-butanediol to 2-butanone; and wherein saidproduct is 2-butanone.
 25. The method of claim 22, wherein saidrecombinant host cell comprises a 2-butanol biosynthetic pathwaycomprising at least one DNA molecule encoding a polypeptide thatcatalyzes a substrate to product conversion selected from the groupconsisting of: (i) pyruvate to acetolactate; (ii) acetolactate toacetoin; (iii) acetoin to 2,3-butanediol; (iv) 2,3-butanediol to2-butanone; and (v) 2-butanone to 2-butanol; and wherein said product is2-butanol.
 26. A method of producing a recombinant host cell comprising:transforming a host cell comprising at least one deletion, mutation,and/or substitution in an endogenous gene encoding a polypeptide havingpyruvate decarboxylase activity with a heterologous polynucleotideencoding a polypeptide having phosphoketolase activity.
 27. The methodof claim 26, wherein said method further comprises: transforming saidrecombinant host cell with a heterologous polynucleotide encoding apolypeptide having phosphotransacetylase activity.
 28. A method ofimproving the growth of a recombinant host cell comprising at least onedeletion, mutation or substitution in an endogenous gene encoding apolypeptide having pyruvate decarboxylase activity, comprising:transforming said recombinant host cell with a heterologouspolynucleotide encoding a polypeptide having phosphoketolase activity.29. The method of claim 28, wherein said method further comprises:transforming said recombinant host cell with a heterologouspolynucleotide encoding a polypeptide having phosphotransacetylaseactivity.
 30. The method of claim 28, further comprising growing therecombinant host cell in media containing limited carbon substrate. 31.A method of reducing the requirement for an exogenous two-carbonsubstrate for the growth of a recombinant host cell comprising at leastone deletion, mutation or substitution in an endogenous gene encoding apolypeptide having pyruvate decarboxylase activity, comprising:transforming said recombinant host cell with a heterologouspolynucleotide encoding a polypeptide having phosphoketolase activity.32. The method of claim 31, wherein said method further comprises:transforming said recombinant host cell with a heterologouspolynucleotide encoding a polypeptide having phosphotransacetylaseactivity.
 33. The recombinant host cell of claim 5 wherein thephosphoketolase matches the Profile HMM given in Table 6 with an E valueof less than 7.5E-242.
 34. The recombinant host cell of claim 5 whereinthe phosphoketolase matches the Profile HMMs given in Tables 6, 7, 8,and 9 with E values of less than 7.5E-242, 1.1E-124, 2.1E-49, 7.8E-37,respectively.
 35. The recombinant host cell of claim 5 furthercomprising a phosphotransacetylase which matches the Profile HMM givenin Table 14 with an E value of less than 5E-34.